EIF4G2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.63366689
2regulation of RNA export from nucleus (GO:0046831)4.44126321
3nuclear pore complex assembly (GO:0051292)4.39289306
4mitotic sister chromatid cohesion (GO:0007064)4.38269576
5nuclear pore organization (GO:0006999)4.21307148
6glucocorticoid receptor signaling pathway (GO:0042921)4.18671099
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85602881
8hippo signaling (GO:0035329)3.79486170
9DNA unwinding involved in DNA replication (GO:0006268)3.77621929
10cytoplasmic mRNA processing body assembly (GO:0033962)3.75868531
11NLS-bearing protein import into nucleus (GO:0006607)3.72774680
12regulation of nucleobase-containing compound transport (GO:0032239)3.63162989
13peptidyl-lysine dimethylation (GO:0018027)3.58557738
14layer formation in cerebral cortex (GO:0021819)3.55042849
15corticosteroid receptor signaling pathway (GO:0031958)3.50838130
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43704161
17regulation of sister chromatid cohesion (GO:0007063)3.40201453
18COPII vesicle coating (GO:0048208)3.37912660
19negative regulation of histone methylation (GO:0031061)3.32046819
20RNA stabilization (GO:0043489)3.30379908
21mRNA stabilization (GO:0048255)3.30379908
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23755703
23dosage compensation (GO:0007549)3.17439324
24glial cell proliferation (GO:0014009)3.12490804
25non-recombinational repair (GO:0000726)3.11820508
26double-strand break repair via nonhomologous end joining (GO:0006303)3.11820508
27establishment of nucleus localization (GO:0040023)3.06325341
28vesicle coating (GO:0006901)3.06236117
29establishment of integrated proviral latency (GO:0075713)3.05058512
30protein localization to kinetochore (GO:0034501)3.02680684
31pyrimidine nucleobase catabolic process (GO:0006208)3.02212199
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01346982
33regulation of NFAT protein import into nucleus (GO:0051532)3.00421343
34pore complex assembly (GO:0046931)3.00198786
35sister chromatid segregation (GO:0000819)2.96866419
36mitotic chromosome condensation (GO:0007076)2.95636816
37membrane disassembly (GO:0030397)2.92277864
38nuclear envelope disassembly (GO:0051081)2.92277864
39positive regulation of mitotic sister chromatid separation (GO:1901970)2.91061043
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91061043
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91061043
42histone H2A monoubiquitination (GO:0035518)2.90443128
43monoubiquitinated protein deubiquitination (GO:0035520)2.90215646
44positive regulation of RNA splicing (GO:0033120)2.87268785
45mitotic nuclear envelope disassembly (GO:0007077)2.85986725
46protein localization to microtubule (GO:0035372)2.85682004
47negative regulation of RNA splicing (GO:0033119)2.83855069
48nucleosome disassembly (GO:0006337)2.83067963
49protein-DNA complex disassembly (GO:0032986)2.83067963
50polarized epithelial cell differentiation (GO:0030859)2.80905650
51peptidyl-arginine methylation (GO:0018216)2.80130422
52peptidyl-arginine N-methylation (GO:0035246)2.80130422
53embryonic foregut morphogenesis (GO:0048617)2.76897700
54gastrulation with mouth forming second (GO:0001702)2.75941128
55regulation of mitotic spindle organization (GO:0060236)2.75137606
56positive regulation of chromosome segregation (GO:0051984)2.75037703
57alternative mRNA splicing, via spliceosome (GO:0000380)2.72319080
58regulation of mRNA stability (GO:0043488)2.72058334
59spliceosomal tri-snRNP complex assembly (GO:0000244)2.71578921
60mitotic sister chromatid segregation (GO:0000070)2.69034159
61heterochromatin organization (GO:0070828)2.68565056
62paraxial mesoderm development (GO:0048339)2.67633955
63stress granule assembly (GO:0034063)2.67316538
64microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.67031721
65negative regulation of DNA repair (GO:0045738)2.66026592
66negative regulation of mRNA processing (GO:0050686)2.64843694
67peptidyl-arginine omega-N-methylation (GO:0035247)2.64614392
68regulation of translational fidelity (GO:0006450)2.63353317
69regulation of histone H3-K9 methylation (GO:0051570)2.63031978
70mitotic metaphase plate congression (GO:0007080)2.61900525
71insulin-like growth factor receptor signaling pathway (GO:0048009)2.60772222
72DNA duplex unwinding (GO:0032508)2.60144966
73Golgi transport vesicle coating (GO:0048200)2.60100135
74COPI coating of Golgi vesicle (GO:0048205)2.60100135
75localization within membrane (GO:0051668)2.59219418
76protein localization to chromosome, centromeric region (GO:0071459)2.57556238
77DNA geometric change (GO:0032392)2.57389601
78germ cell migration (GO:0008354)2.56402749
79ectodermal placode formation (GO:0060788)2.55959183
80spindle assembly involved in mitosis (GO:0090307)2.55611536
81negative regulation of mRNA metabolic process (GO:1903312)2.55517220
82morphogenesis of an epithelial sheet (GO:0002011)2.55279666
83DNA topological change (GO:0006265)2.55205161
84planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55135189
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54143915
86regulation of spindle organization (GO:0090224)2.52528351
87gene silencing by RNA (GO:0031047)2.51222714
88mitotic cytokinesis (GO:0000281)2.50995882
89dorsal/ventral axis specification (GO:0009950)2.50892496
90nuclear envelope organization (GO:0006998)2.50689704
91negative regulation of catenin import into nucleus (GO:0035414)2.49474783
92establishment of spindle orientation (GO:0051294)2.49324244
93regulation of hippo signaling (GO:0035330)2.48764013
94regulation of RNA stability (GO:0043487)2.48759176
95positive regulation of SMAD protein import into nucleus (GO:0060391)2.48215695
96embryonic process involved in female pregnancy (GO:0060136)2.48095976
97cell adhesion mediated by integrin (GO:0033627)2.46813210
98cellular protein complex localization (GO:0034629)2.45299895
99regulation of translational termination (GO:0006449)2.44334170
100cell migration in hindbrain (GO:0021535)2.42255671
101apical protein localization (GO:0045176)2.42248752
102protein localization to endosome (GO:0036010)2.42009852
103establishment of chromosome localization (GO:0051303)2.41538826
104clathrin coat assembly (GO:0048268)2.41380553
105protein export from nucleus (GO:0006611)2.40955448
106cytoskeleton-dependent cytokinesis (GO:0061640)2.40720466
107metaphase plate congression (GO:0051310)2.39357250
108epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39068772
109negative regulation of cell size (GO:0045792)2.38930288
110negative regulation of microtubule polymerization (GO:0031115)2.38709551
111histone H3-K9 demethylation (GO:0033169)2.38114803
112gene silencing (GO:0016458)2.37910950
113asymmetric protein localization (GO:0008105)2.37817061
114positive regulation of cell cycle checkpoint (GO:1901978)2.37386927
115regulation of DNA damage checkpoint (GO:2000001)2.37009154
1163-UTR-mediated mRNA stabilization (GO:0070935)2.36700319
117nucleus localization (GO:0051647)2.36278035
118protein localization to chromosome (GO:0034502)2.36010404
119lens morphogenesis in camera-type eye (GO:0002089)2.35820046
120ganglion development (GO:0061548)2.35680051
121axon extension (GO:0048675)2.35264907
122negative regulation of histone modification (GO:0031057)2.34841367
123regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.32868303
124regulation of chromosome segregation (GO:0051983)2.32252920
125mitotic spindle organization (GO:0007052)2.31437630
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.31279869
127protein complex localization (GO:0031503)2.30972085
128chromatin assembly (GO:0031497)2.29885035
129negative regulation of fibroblast apoptotic process (GO:2000270)2.29575234
130translesion synthesis (GO:0019985)2.29282335
131regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.28464231
132membrane budding (GO:0006900)2.25784916
133regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23784792
134regulation of transforming growth factor beta2 production (GO:0032909)2.22747145
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.22179442
136regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.21728792
137retina vasculature morphogenesis in camera-type eye (GO:0061299)2.21412656
138establishment of spindle localization (GO:0051293)2.20622959
139regulation of centriole replication (GO:0046599)2.20205759
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19470524
141notochord development (GO:0030903)2.19163156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77559016
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.48324024
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.71093992
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.05577732
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.38451226
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.36529332
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.10266183
8MYC_22102868_ChIP-Seq_BL_Human3.08748558
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.67648650
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56110994
11SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.29574664
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20854352
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17488460
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15934569
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11967424
16DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.11337718
17CLOCK_20551151_ChIP-Seq_293T_Human2.03354287
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00848977
19AR_21909140_ChIP-Seq_LNCAP_Human1.97646355
20ZNF263_19887448_ChIP-Seq_K562_Human1.96455430
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96442391
22* KDM2B_26808549_Chip-Seq_DND41_Human1.93868278
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91371399
24PKCTHETA_26484144_Chip-Seq_BREAST_Human1.89202646
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88008685
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84978183
27* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84025173
28* TCF7_22412390_ChIP-Seq_EML_Mouse1.79444915
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.77042722
30* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75098833
31FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.73111210
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.67814921
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67693710
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66240308
35* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65433868
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65105101
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62814743
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60712934
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.60647870
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56310609
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55248795
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55068012
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53257660
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50314333
45* CHD1_26751641_Chip-Seq_LNCaP_Human1.47961557
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47165669
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46047648
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42312529
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41287533
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41038935
51NANOG_21062744_ChIP-ChIP_HESCs_Human1.40873610
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38965851
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38178827
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.37112125
55EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36728724
56* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.34132425
57KDM2B_26808549_Chip-Seq_K562_Human1.33548807
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.30877173
59SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29711941
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29084399
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.28609374
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.28155622
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27680719
64* CIITA_25753668_ChIP-Seq_RAJI_Human1.26648129
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24102271
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22256933
67* MYC_18555785_ChIP-Seq_MESCs_Mouse1.20960461
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20148937
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20148937
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.19299804
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18947080
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18363488
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17633080
74BRD4_25478319_ChIP-Seq_HGPS_Human1.15875955
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15757609
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14378789
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13257385
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13021832
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12965986
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12532231
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.12432404
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12099874
83TAF15_26573619_Chip-Seq_HEK293_Human1.12038841
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11150229
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10640963
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09929536
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09238874
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08504312
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07481641
90* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07252020
91ZNF274_21170338_ChIP-Seq_K562_Hela1.05556598
92VDR_21846776_ChIP-Seq_THP-1_Human1.04981615
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04252835
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03354742
95IGF1R_20145208_ChIP-Seq_DFB_Human1.02267881
96* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01732686
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01633570
98CREB1_26743006_Chip-Seq_LNCaP_Human1.01581824
99SOX9_26525672_Chip-Seq_HEART_Mouse1.01108424
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01018851
101TCF4_18268006_ChIP-ChIP_LS174T_Human0.99686821
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99563748
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99305804
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99260067
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98662740
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98566185
107* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97325049
108REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97144458
109MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96633669
110FUS_26573619_Chip-Seq_HEK293_Human0.96283061
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95913036
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95905887
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95642816
114* UTX_26944678_Chip-Seq_JUKART_Human0.95033369
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94819594
116TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94485983
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94326047
118ATF3_27146783_Chip-Seq_COLON_Human0.93790703
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92785251
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92563317
121* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92523839
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91826534
123ELK1_19687146_ChIP-ChIP_HELA_Human0.91384289
124* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91332537
125POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91039633
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90960913
127* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90421922
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89372719
129* KDM5A_27292631_Chip-Seq_BREAST_Human0.88466709
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88157230
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.87967319
132TP63_17297297_ChIP-ChIP_HaCaT_Human0.86950207
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.86745684
134* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86259217
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85177810
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85021829
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84993239
138NCOR1_26117541_ChIP-Seq_K562_Human0.83623482
139* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83019664
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.82429663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.40763849
2MP0000569_abnormal_digit_pigmentation3.15034130
3MP0003705_abnormal_hypodermis_morpholog3.14087466
4MP0010352_gastrointestinal_tract_polyps3.00485249
5MP0010234_abnormal_vibrissa_follicle2.42748720
6* MP0005076_abnormal_cell_differentiation2.39015234
7MP0009053_abnormal_anal_canal2.36678719
8MP0005187_abnormal_penis_morphology2.23033060
9MP0002009_preneoplasia2.19338573
10MP0003123_paternal_imprinting2.18619159
11MP0000566_synostosis2.02322155
12MP0003121_genomic_imprinting1.94268244
13MP0004197_abnormal_fetal_growth/weight/1.89338678
14MP0003890_abnormal_embryonic-extraembry1.88634418
15MP0001730_embryonic_growth_arrest1.86388077
16MP0000733_abnormal_muscle_development1.84878523
17* MP0002084_abnormal_developmental_patter1.82750127
18MP0006054_spinal_hemorrhage1.79050013
19MP0003300_gastrointestinal_ulcer1.72889466
20MP0003111_abnormal_nucleus_morphology1.70908933
21MP0000428_abnormal_craniofacial_morphol1.68676048
22MP0004233_abnormal_muscle_weight1.68077355
23MP0010094_abnormal_chromosome_stability1.67962428
24MP0003567_abnormal_fetal_cardiomyocyte1.67354328
25MP0005623_abnormal_meninges_morphology1.66362234
26MP0003119_abnormal_digestive_system1.65954654
27MP0001849_ear_inflammation1.65757502
28MP0000350_abnormal_cell_proliferation1.63082369
29* MP0002085_abnormal_embryonic_tissue1.59439070
30MP0009780_abnormal_chondrocyte_physiolo1.58163220
31MP0003115_abnormal_respiratory_system1.57275301
32MP0005257_abnormal_intraocular_pressure1.57057410
33MP0003077_abnormal_cell_cycle1.53661704
34MP0010030_abnormal_orbit_morphology1.53540426
35MP0005409_darkened_coat_color1.52480896
36MP0001697_abnormal_embryo_size1.51850134
37* MP0001672_abnormal_embryogenesis/_devel1.51832925
38* MP0005380_embryogenesis_phenotype1.51832925
39MP0010307_abnormal_tumor_latency1.51775115
40MP0009672_abnormal_birth_weight1.50870634
41MP0003385_abnormal_body_wall1.49759106
42* MP0002088_abnormal_embryonic_growth/wei1.49336968
43* MP0003984_embryonic_growth_retardation1.48261922
44MP0000778_abnormal_nervous_system1.46322937
45MP0003935_abnormal_craniofacial_develop1.45364702
46MP0009703_decreased_birth_body1.44334647
47MP0002086_abnormal_extraembryonic_tissu1.43715383
48MP0003861_abnormal_nervous_system1.43218042
49MP0003941_abnormal_skin_development1.41975171
50MP0005248_abnormal_Harderian_gland1.41089317
51MP0004957_abnormal_blastocyst_morpholog1.40825102
52MP0001299_abnormal_eye_distance/1.38950344
53MP0000751_myopathy1.34411115
54MP0003283_abnormal_digestive_organ1.33951427
55MP0003942_abnormal_urinary_system1.31268820
56MP0003122_maternal_imprinting1.31110910
57MP0002877_abnormal_melanocyte_morpholog1.29925049
58MP0000534_abnormal_ureter_morphology1.29054010
59MP0003937_abnormal_limbs/digits/tail_de1.28781463
60MP0003303_peritoneal_inflammation1.27474094
61MP0001293_anophthalmia1.25500141
62* MP0002080_prenatal_lethality1.24005213
63MP0008961_abnormal_basal_metabolism1.19986826
64MP0002234_abnormal_pharynx_morphology1.19912250
65MP0002092_abnormal_eye_morphology1.19883237
66MP0001177_atelectasis1.17873258
67MP0003221_abnormal_cardiomyocyte_apopto1.17825553
68MP0002653_abnormal_ependyma_morphology1.16898377
69MP0002925_abnormal_cardiovascular_devel1.16561309
70MP0008007_abnormal_cellular_replicative1.15935628
71MP0009278_abnormal_bone_marrow1.15394839
72MP0009697_abnormal_copulation1.13900273
73MP0003755_abnormal_palate_morphology1.13775296
74MP0010678_abnormal_skin_adnexa1.13461126
75MP0004185_abnormal_adipocyte_glucose1.13256981
76MP0002751_abnormal_autonomic_nervous1.12794441
77MP0004808_abnormal_hematopoietic_stem1.12730089
78MP0005367_renal/urinary_system_phenotyp1.10028991
79MP0000516_abnormal_urinary_system1.10028991
80MP0004270_analgesia1.09720463
81MP0002697_abnormal_eye_size1.08321520
82MP0001915_intracranial_hemorrhage1.07160200
83MP0002896_abnormal_bone_mineralization1.07058325
84MP0005501_abnormal_skin_physiology1.06682133
85MP0003566_abnormal_cell_adhesion1.05648704
86MP0003787_abnormal_imprinting1.05053670
87MP0000432_abnormal_head_morphology1.04598089
88MP0010368_abnormal_lymphatic_system1.04579534
89MP0008057_abnormal_DNA_replication1.03718518
90MP0002116_abnormal_craniofacial_bone1.03693795
91MP0002081_perinatal_lethality0.99949688
92MP0005499_abnormal_olfactory_system0.99735387
93MP0005394_taste/olfaction_phenotype0.99735387
94MP0002282_abnormal_trachea_morphology0.99355955
95MP0003091_abnormal_cell_migration0.97994758
96MP0004811_abnormal_neuron_physiology0.96461231
97MP0000467_abnormal_esophagus_morphology0.96418472
98MP0000579_abnormal_nail_morphology0.95121600
99MP0002932_abnormal_joint_morphology0.93785808
100MP0003693_abnormal_embryo_hatching0.93366180
101MP0002796_impaired_skin_barrier0.93346663
102MP0001529_abnormal_vocalization0.93149741
103* MP0005621_abnormal_cell_physiology0.92768222
104MP0002233_abnormal_nose_morphology0.91693565
105MP0005275_abnormal_skin_tensile0.91637534
106MP0004782_abnormal_surfactant_physiolog0.91177647
107MP0000647_abnormal_sebaceous_gland0.90771973
108MP0000383_abnormal_hair_follicle0.90552978
109MP0010630_abnormal_cardiac_muscle0.89596088
110MP0002102_abnormal_ear_morphology0.89267480
111MP0001879_abnormal_lymphatic_vessel0.89185816
112MP0002822_catalepsy0.89094418
113MP0001188_hyperpigmentation0.88520888
114MP0008058_abnormal_DNA_repair0.88032628
115MP0000266_abnormal_heart_morphology0.87858395
116MP0002111_abnormal_tail_morphology0.87268085
117MP0000377_abnormal_hair_follicle0.86286542
118MP0000762_abnormal_tongue_morphology0.85007311
119MP0002060_abnormal_skin_morphology0.84909635
120MP0002089_abnormal_postnatal_growth/wei0.84544592
121MP0008789_abnormal_olfactory_epithelium0.84404537
122MP0001286_abnormal_eye_development0.82944732
123MP0002184_abnormal_innervation0.82511228
124MP0004272_abnormal_basement_membrane0.82002717
125MP0002152_abnormal_brain_morphology0.81755731
126MP0009250_abnormal_appendicular_skeleto0.81239049
127MP0008770_decreased_survivor_rate0.79733638
128MP0008438_abnormal_cutaneous_collagen0.79587019
129MP0001348_abnormal_lacrimal_gland0.79416281
130MP0004084_abnormal_cardiac_muscle0.79316714
131MP0000003_abnormal_adipose_tissue0.79294186
132MP0008932_abnormal_embryonic_tissue0.79123480
133MP0004885_abnormal_endolymph0.78702843

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.13833809
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.13833809
3Hyperacusis (HP:0010780)3.32372504
4Abnormality of the 4th metacarpal (HP:0010012)3.28374703
5Shallow orbits (HP:0000586)2.98839611
6Renal duplication (HP:0000075)2.95610767
7Subacute progressive viral hepatitis (HP:0006572)2.87874510
8Macroorchidism (HP:0000053)2.84864724
9Increased nuchal translucency (HP:0010880)2.84389140
10Elfin facies (HP:0004428)2.72170198
11Volvulus (HP:0002580)2.70704574
12Abnormality of the astrocytes (HP:0100707)2.64104179
13Astrocytoma (HP:0009592)2.64104179
14Cortical dysplasia (HP:0002539)2.55418976
15Renovascular hypertension (HP:0100817)2.55390938
16Overriding aorta (HP:0002623)2.50219167
17Vertebral arch anomaly (HP:0008438)2.49723031
18Heterotopia (HP:0002282)2.45540303
19Premature rupture of membranes (HP:0001788)2.43024935
20Colon cancer (HP:0003003)2.41050645
21Pelvic girdle muscle weakness (HP:0003749)2.39218189
22Shoulder girdle muscle weakness (HP:0003547)2.37089527
23Ependymoma (HP:0002888)2.36313534
24Amyotrophic lateral sclerosis (HP:0007354)2.35185032
25Termporal pattern (HP:0011008)2.32713322
26Insidious onset (HP:0003587)2.32713322
27Bowel diverticulosis (HP:0005222)2.28746876
28Sacral dimple (HP:0000960)2.26964404
29Proximal placement of thumb (HP:0009623)2.26710842
30Deviation of the thumb (HP:0009603)2.25679756
31Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.25581075
32Papillary thyroid carcinoma (HP:0002895)2.25122895
33Urinary urgency (HP:0000012)2.24912645
34Lymphangioma (HP:0100764)2.22220760
35Insomnia (HP:0100785)2.21350208
36Disinhibition (HP:0000734)2.21105799
37Enlarged penis (HP:0000040)2.19770354
38Hammertoe (HP:0001765)2.17051915
39Pointed chin (HP:0000307)2.11280591
40Asymmetry of the thorax (HP:0001555)2.11144583
41Spinal cord lesions (HP:0100561)2.10658255
42Syringomyelia (HP:0003396)2.10658255
43Arterial tortuosity (HP:0005116)2.09641292
44High anterior hairline (HP:0009890)2.09417124
45Trigonocephaly (HP:0000243)2.08272685
46Deep philtrum (HP:0002002)2.07495034
47Hallux valgus (HP:0001822)2.07306361
48Gastrointestinal carcinoma (HP:0002672)2.07098849
49Malignant gastrointestinal tract tumors (HP:0006749)2.07098849
50Autoamputation (HP:0001218)2.06967618
51Obsessive-compulsive behavior (HP:0000722)2.06706381
52Abnormality of the hip-girdle musculature (HP:0001445)2.06379425
53Abnormality of the musculature of the pelvis (HP:0001469)2.06379425
54Increased density of long bones (HP:0006392)2.06021716
55Deviation of the hallux (HP:0010051)2.05759161
56Hepatoblastoma (HP:0002884)2.05280791
57Ankyloglossia (HP:0010296)2.04681725
58Large earlobe (HP:0009748)2.04537270
59Cerebral aneurysm (HP:0004944)2.03844334
60Fibrous tissue neoplasm (HP:0012316)2.03572621
61Transitional cell carcinoma of the bladder (HP:0006740)2.01337663
62Thyroid carcinoma (HP:0002890)2.00968819
63Spastic diplegia (HP:0001264)2.00583953
64Cutis marmorata (HP:0000965)1.98733193
65Rectal prolapse (HP:0002035)1.97623182
66Flat cornea (HP:0007720)1.97491547
67Fibroma (HP:0010614)1.96870877
68Glioma (HP:0009733)1.96795864
69Medulloblastoma (HP:0002885)1.96505265
70Bladder diverticulum (HP:0000015)1.96304099
71Inappropriate behavior (HP:0000719)1.93864647
72Narrow palate (HP:0000189)1.92712266
73Limb-girdle muscle atrophy (HP:0003797)1.91963956
74Vascular tortuosity (HP:0004948)1.90903783
75Bladder carcinoma (HP:0002862)1.88539535
76Bladder neoplasm (HP:0009725)1.88539535
77Lower limb amyotrophy (HP:0007210)1.87362663
78Exostoses (HP:0100777)1.86697712
79Aqueductal stenosis (HP:0002410)1.86289979
80Leiomyosarcoma (HP:0100243)1.84545350
81Uterine leiomyosarcoma (HP:0002891)1.84545350
82Apathy (HP:0000741)1.84427451
83Neoplasm of the adrenal cortex (HP:0100641)1.84249672
84Wrist flexion contracture (HP:0001239)1.83530129
85Broad thumb (HP:0011304)1.83519921
86Abnormality of the lower motor neuron (HP:0002366)1.83271522
87Curly hair (HP:0002212)1.83054763
88Long eyelashes (HP:0000527)1.83019501
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81657134
90Abnormality of the diencephalon (HP:0010662)1.81015656
91Megalocornea (HP:0000485)1.80075177
92Buphthalmos (HP:0000557)1.78872750
93Facial hemangioma (HP:0000329)1.78759546
94Abnormality of oral frenula (HP:0000190)1.78326843
95Protrusio acetabuli (HP:0003179)1.77156169
96Unilateral renal agenesis (HP:0000122)1.75541371
97Intestinal polyp (HP:0005266)1.75183835
98Arnold-Chiari malformation (HP:0002308)1.74605913
99Ulnar bowing (HP:0003031)1.73391271
100Mitral valve prolapse (HP:0001634)1.72045540
101Intestinal polyposis (HP:0200008)1.71925435
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.71415311
103Abnormality of the distal phalanx of the thumb (HP:0009617)1.71314980
104Hand muscle atrophy (HP:0009130)1.71015344
105Open mouth (HP:0000194)1.70399785
106Relative macrocephaly (HP:0004482)1.70312544
107Papilledema (HP:0001085)1.70237392
108Ankle contracture (HP:0006466)1.70212346
109Thick eyebrow (HP:0000574)1.69638896
110Broad palm (HP:0001169)1.68876376
111Diminished motivation (HP:0000745)1.68407598
112Distal lower limb amyotrophy (HP:0008944)1.67598622
113Drooling (HP:0002307)1.67511873
114Cystic hygroma (HP:0000476)1.67378563
115Dilatation of the ascending aorta (HP:0005111)1.67337881
116Aortic aneurysm (HP:0004942)1.67080935
117Pseudobulbar signs (HP:0002200)1.66651964
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.66509729
119Skull defect (HP:0001362)1.66169715
120Broad nasal tip (HP:0000455)1.65436720
121Overlapping toe (HP:0001845)1.64711613
122Neoplasm of the heart (HP:0100544)1.64122860
123Smooth philtrum (HP:0000319)1.64083507
124Abnormal auditory evoked potentials (HP:0006958)1.63760756
125Neoplasm of the oral cavity (HP:0100649)1.63542022
126Genu recurvatum (HP:0002816)1.62768427
127Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.62108698
128Limb-girdle muscle weakness (HP:0003325)1.61139309
129Truncal obesity (HP:0001956)1.60791543
130Uterine neoplasm (HP:0010784)1.59755972
131Abnormality of the calcaneus (HP:0008364)1.59639417
132Germ cell neoplasia (HP:0100728)1.59440511
133Long palpebral fissure (HP:0000637)1.59101654
134Spina bifida occulta (HP:0003298)1.57029160
135Distal upper limb amyotrophy (HP:0007149)1.56116987
136Upper limb amyotrophy (HP:0009129)1.56116987
137Back pain (HP:0003418)1.55935157
138Renal cell carcinoma (HP:0005584)1.55356687
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54948543
140Menstrual irregularities (HP:0000858)1.54701572
141Pulmonic stenosis (HP:0001642)1.53313478
142Generalized hypotonia (HP:0001290)1.52657915
143Abnormality of chromosome segregation (HP:0002916)1.49772275
144Progressive sensorineural hearing impairment (HP:0000408)1.48210080
145Flat acetabular roof (HP:0003180)1.47229466
146Excessive salivation (HP:0003781)1.46884440
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.46681264
148Osteolytic defects of the hand bones (HP:0009699)1.46681264
149Cubitus valgus (HP:0002967)1.46392070
150Nephroblastoma (Wilms tumor) (HP:0002667)1.44960434
151Abnormality of the phalanges of the hallux (HP:0010057)1.44475687
152Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.44349809
153Vertebral clefting (HP:0008428)1.43648736
154Short nail (HP:0001799)1.42982231
155Lower limb muscle weakness (HP:0007340)1.42785997
156Complete atrioventricular canal defect (HP:0001674)1.42095265
157Embryonal renal neoplasm (HP:0011794)1.41993193
158Broad face (HP:0000283)1.41811038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.80526062
2BCR3.47830744
3TRIB33.40311860
4SRPK13.15287116
5PKN22.97634932
6CDK122.80299106
7MAP3K102.76593904
8EEF2K2.65751376
9CDC72.41027206
10SCYL22.29248700
11LATS12.28007288
12TRIM282.27781507
13ERBB32.03410824
14SIK31.98638191
15LATS21.84337747
16PDGFRA1.76799875
17PTK61.72470595
18RIPK11.62371480
19ALK1.60066151
20KSR11.59256047
21TTN1.54975919
22NEK21.53604415
23MST1R1.52131891
24FGFR21.47441391
25MET1.46789784
26ERBB41.42258261
27NEK11.41909586
28CDK61.39877570
29EPHB21.39373923
30CAMK1G1.37226295
31MTOR1.32786579
32MAP2K71.30306068
33EIF2AK11.30014002
34FGFR11.28855557
35MKNK11.25334539
36BRD41.24098844
37TYRO31.23940817
38NTRK11.23439333
39PASK1.22480794
40ICK1.21739380
41STK31.12676668
42CAMK1D1.10842534
43TGFBR11.10014674
44DYRK21.07843476
45RET1.07090511
46CASK1.06909272
47EIF2AK31.03879314
48STK38L1.00680847
49FGFR31.00339686
50PLK31.00142848
51TESK11.00102472
52MAP3K90.99707819
53DMPK0.99501759
54CSNK1A1L0.98808534
55PBK0.98155656
56STK100.96069331
57PNCK0.95433623
58LIMK10.93492654
59MAP3K60.91835290
60PDGFRB0.91294809
61BRSK20.88540551
62EPHA20.88233832
63MINK10.86258903
64TSSK60.85087507
65CSNK1G20.84731472
66CHEK10.84490265
67PAK20.83220428
68PAK40.80997965
69SIK20.80870883
70CDK40.80465156
71MAP3K40.80419833
72PAK60.79822412
73LRRK20.77430826
74NEK90.77169939
75DYRK1A0.77002461
76CDK180.76688913
77PRKD30.75009575
78ATR0.74231362
79YES10.73160309
80TAOK10.73047464
81DDR20.72900649
82LMTK20.72564828
83MKNK20.72195820
84MAP3K80.72066395
85PHKG20.68880105
86PHKG10.68880105
87DYRK1B0.67457695
88ERBB20.66673500
89CSNK1G30.66538295
90PAK30.66463328
91AKT30.64040817
92BRSK10.64028888
93TAOK20.63917561
94CDK150.63712966
95* CDK20.63565080
96SIK10.63325186
97FRK0.62593567
98CSNK1D0.62572560
99CDK70.62220900
100KSR20.61963122
101TTK0.60859451
102ATM0.60055794
103FER0.59247056
104RPS6KB20.59207625
105PLK40.59007212
106CHEK20.58916589
107CDK10.58098990
108NTRK20.57228933
109MAP3K50.57021728
110SMG10.56710216
111MELK0.56384764
112MAP3K20.56210779
113RPS6KA40.56166798
114PTK20.55735049
115CDK11A0.54562450
116BUB10.54025934
117NEK60.53254099
118CSNK1G10.52929605
119DYRK30.52883696
120TESK20.52817442
121EPHB10.52751376
122EPHA30.52733940
123ILK0.51552177
124CDK140.51066879
125CDK90.49238221
126PRKDC0.49226587
127RPS6KA20.48766648
128PLK10.48662407
129ACVR1B0.46219915
130MAPK90.46150341
131CDK80.45916247
132PLK20.45649946
133WEE10.45401353
134AURKB0.44839709
135PDK40.44382213
136PDK30.44382213
137CSNK1E0.44273696
138MAPK100.44172577
139FGFR40.42596699

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01601035
2Colorectal cancer_Homo sapiens_hsa052102.00299205
3Endometrial cancer_Homo sapiens_hsa052131.94926604
4Non-homologous end-joining_Homo sapiens_hsa034501.93484688
5Chronic myeloid leukemia_Homo sapiens_hsa052201.90610693
6mRNA surveillance pathway_Homo sapiens_hsa030151.80595117
7Hippo signaling pathway_Homo sapiens_hsa043901.78229161
8Cell cycle_Homo sapiens_hsa041101.76717883
9mTOR signaling pathway_Homo sapiens_hsa041501.73417327
10MicroRNAs in cancer_Homo sapiens_hsa052061.71825908
11Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.67157481
12Basal cell carcinoma_Homo sapiens_hsa052171.67026892
13Adherens junction_Homo sapiens_hsa045201.62584017
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59314823
15Glioma_Homo sapiens_hsa052141.50266334
16Renal cell carcinoma_Homo sapiens_hsa052111.49783914
17Oocyte meiosis_Homo sapiens_hsa041141.46087485
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43553789
19Proteoglycans in cancer_Homo sapiens_hsa052051.43374532
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.43327210
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42615435
22Pancreatic cancer_Homo sapiens_hsa052121.41657221
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40991269
24Small cell lung cancer_Homo sapiens_hsa052221.39096669
25* RNA transport_Homo sapiens_hsa030131.38202080
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36161232
27Axon guidance_Homo sapiens_hsa043601.36041944
28Non-small cell lung cancer_Homo sapiens_hsa052231.34758764
29* Viral myocarditis_Homo sapiens_hsa054161.29480177
30Focal adhesion_Homo sapiens_hsa045101.28223545
31Hedgehog signaling pathway_Homo sapiens_hsa043401.27398597
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.26171471
33Viral carcinogenesis_Homo sapiens_hsa052031.22598652
34Estrogen signaling pathway_Homo sapiens_hsa049151.21044352
35Steroid biosynthesis_Homo sapiens_hsa001001.19176119
36Lysine degradation_Homo sapiens_hsa003101.18434655
37Notch signaling pathway_Homo sapiens_hsa043301.16319405
38HTLV-I infection_Homo sapiens_hsa051661.16118556
39Dorso-ventral axis formation_Homo sapiens_hsa043201.13851950
40Wnt signaling pathway_Homo sapiens_hsa043101.11143894
41Prostate cancer_Homo sapiens_hsa052151.11008075
42Spliceosome_Homo sapiens_hsa030401.10212607
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09322544
44TGF-beta signaling pathway_Homo sapiens_hsa043501.09283285
45Type II diabetes mellitus_Homo sapiens_hsa049301.09104532
46VEGF signaling pathway_Homo sapiens_hsa043701.07239466
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07194845
48Tight junction_Homo sapiens_hsa045301.07041051
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06480608
50ErbB signaling pathway_Homo sapiens_hsa040121.04323480
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02839398
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02703857
53AMPK signaling pathway_Homo sapiens_hsa041521.01144545
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99958375
55Thyroid cancer_Homo sapiens_hsa052160.97877460
56Insulin signaling pathway_Homo sapiens_hsa049100.97305234
57Insulin resistance_Homo sapiens_hsa049310.94999406
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93114160
59Pathways in cancer_Homo sapiens_hsa052000.92399746
60Vibrio cholerae infection_Homo sapiens_hsa051100.92227638
61Biosynthesis of amino acids_Homo sapiens_hsa012300.91557251
62FoxO signaling pathway_Homo sapiens_hsa040680.91399304
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89973483
64Bladder cancer_Homo sapiens_hsa052190.89953798
65Gap junction_Homo sapiens_hsa045400.87848281
66Prolactin signaling pathway_Homo sapiens_hsa049170.85930410
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85495646
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85490301
69Melanogenesis_Homo sapiens_hsa049160.84326983
70Hepatitis B_Homo sapiens_hsa051610.84066843
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83380978
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82631537
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.82603157
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81970960
75p53 signaling pathway_Homo sapiens_hsa041150.81610995
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81478357
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80296725
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79953381
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79787544
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79695236
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78914305
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78269779
83T cell receptor signaling pathway_Homo sapiens_hsa046600.78009163
84Alcoholism_Homo sapiens_hsa050340.75392874
85Toxoplasmosis_Homo sapiens_hsa051450.75319519
86Acute myeloid leukemia_Homo sapiens_hsa052210.74155737
87ECM-receptor interaction_Homo sapiens_hsa045120.73925165
88Circadian rhythm_Homo sapiens_hsa047100.73875219
89Endocytosis_Homo sapiens_hsa041440.73589235
90Melanoma_Homo sapiens_hsa052180.73361932
91Inositol phosphate metabolism_Homo sapiens_hsa005620.73336860
92Dopaminergic synapse_Homo sapiens_hsa047280.71799656
93Long-term potentiation_Homo sapiens_hsa047200.71723234
94B cell receptor signaling pathway_Homo sapiens_hsa046620.70731803
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70274060
96Amoebiasis_Homo sapiens_hsa051460.68960263
97Rap1 signaling pathway_Homo sapiens_hsa040150.68891912
98Glucagon signaling pathway_Homo sapiens_hsa049220.68494084
99Salmonella infection_Homo sapiens_hsa051320.68349517
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68216061
101Platelet activation_Homo sapiens_hsa046110.68010054
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67506324
103DNA replication_Homo sapiens_hsa030300.67373035
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67219124
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64303790
106MAPK signaling pathway_Homo sapiens_hsa040100.63754854
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63739920
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63697615
109Epstein-Barr virus infection_Homo sapiens_hsa051690.63149887
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60691739
111Antigen processing and presentation_Homo sapiens_hsa046120.60461759
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60060036
113HIF-1 signaling pathway_Homo sapiens_hsa040660.59946007
114Choline metabolism in cancer_Homo sapiens_hsa052310.59939755
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59837121
116Dilated cardiomyopathy_Homo sapiens_hsa054140.59213757
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.58983783
118Nucleotide excision repair_Homo sapiens_hsa034200.56178767
119Shigellosis_Homo sapiens_hsa051310.54445988
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.54332209
121Long-term depression_Homo sapiens_hsa047300.53228628
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51680354
123Mismatch repair_Homo sapiens_hsa034300.51410413
124Carbon metabolism_Homo sapiens_hsa012000.51051058
125GnRH signaling pathway_Homo sapiens_hsa049120.47342893
126Apoptosis_Homo sapiens_hsa042100.45268943

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