EIF4G3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.71557828
2locomotory exploration behavior (GO:0035641)4.59247711
3synaptic vesicle maturation (GO:0016188)4.40244316
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39251340
5mitotic sister chromatid cohesion (GO:0007064)4.23724196
6vocalization behavior (GO:0071625)4.23058814
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17034170
8layer formation in cerebral cortex (GO:0021819)4.09410529
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06196701
10synaptic vesicle exocytosis (GO:0016079)3.99924408
11neuron cell-cell adhesion (GO:0007158)3.78340418
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.75487814
13glutamate secretion (GO:0014047)3.74835935
14dendritic spine morphogenesis (GO:0060997)3.70362872
15regulation of glutamate receptor signaling pathway (GO:1900449)3.64757840
16protein localization to synapse (GO:0035418)3.57811154
17regulation of synaptic vesicle exocytosis (GO:2000300)3.56366622
18regulation of NFAT protein import into nucleus (GO:0051532)3.54667348
19cerebellar Purkinje cell differentiation (GO:0021702)3.47652030
20neuron recognition (GO:0008038)3.47013249
21exploration behavior (GO:0035640)3.43257748
22cellular potassium ion homeostasis (GO:0030007)3.38437435
23neuronal action potential propagation (GO:0019227)3.37314004
24neurotransmitter secretion (GO:0007269)3.30890986
25glutamate receptor signaling pathway (GO:0007215)3.30168729
26sodium ion export (GO:0071436)3.24690968
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24007788
28axonal fasciculation (GO:0007413)3.22082398
29dendrite morphogenesis (GO:0048813)3.22061885
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.21380075
31nuclear pore complex assembly (GO:0051292)3.19506612
32regulation of neuronal synaptic plasticity (GO:0048168)3.19378903
33histone H3-K9 demethylation (GO:0033169)3.19003913
34gamma-aminobutyric acid transport (GO:0015812)3.15875993
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11256915
36presynaptic membrane organization (GO:0097090)3.08270395
37regulation of synaptic vesicle transport (GO:1902803)3.06584972
38synaptic transmission, glutamatergic (GO:0035249)3.05559597
39embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98209531
40presynaptic membrane assembly (GO:0097105)2.97517953
41regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97124691
42cell migration in hindbrain (GO:0021535)2.96141517
43regulation of ARF protein signal transduction (GO:0032012)2.96033731
44synaptic vesicle endocytosis (GO:0048488)2.95926324
45regulation of synapse structural plasticity (GO:0051823)2.94200544
46paraxial mesoderm development (GO:0048339)2.90599513
47regulation of dendritic spine morphogenesis (GO:0061001)2.89757219
48activation of protein kinase A activity (GO:0034199)2.88803763
49regulation of postsynaptic membrane potential (GO:0060078)2.88299007
50protein targeting to Golgi (GO:0000042)2.88061786
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87780947
52sister chromatid cohesion (GO:0007062)2.87490733
53gamma-aminobutyric acid signaling pathway (GO:0007214)2.87408750
54long-term memory (GO:0007616)2.85625578
55membrane depolarization during action potential (GO:0086010)2.82515298
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82108431
57neuron-neuron synaptic transmission (GO:0007270)2.81307587
58mating behavior (GO:0007617)2.79415276
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79262328
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78576131
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78021719
62apical protein localization (GO:0045176)2.77964709
63cerebellar granule cell differentiation (GO:0021707)2.77798007
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76406792
65transmission of nerve impulse (GO:0019226)2.76209274
66positive regulation of membrane potential (GO:0045838)2.74574660
67potassium ion import (GO:0010107)2.73791018
68regulation of DNA endoreduplication (GO:0032875)2.73524027
69establishment of protein localization to Golgi (GO:0072600)2.71525225
70neurotransmitter transport (GO:0006836)2.71297967
71neuronal ion channel clustering (GO:0045161)2.70856747
72establishment of nucleus localization (GO:0040023)2.66707482
73NLS-bearing protein import into nucleus (GO:0006607)2.66636024
74nuclear pore organization (GO:0006999)2.66554434
75central nervous system projection neuron axonogenesis (GO:0021952)2.66215204
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.65936423
77vesicle transport along microtubule (GO:0047496)2.65199352
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64473071
79DNA synthesis involved in DNA repair (GO:0000731)2.62314501
80neuromuscular process controlling balance (GO:0050885)2.62288779
81membrane depolarization (GO:0051899)2.61418537
82cell differentiation in hindbrain (GO:0021533)2.61363081
83regulation of synaptic plasticity (GO:0048167)2.60725461
84cytoskeletal anchoring at plasma membrane (GO:0007016)2.59969853
85proline transport (GO:0015824)2.59344504
86innervation (GO:0060384)2.58767236
87synapsis (GO:0007129)2.57926083
88embryonic body morphogenesis (GO:0010172)2.56878139
89synapse organization (GO:0050808)2.56394324
90regulation of neurotransmitter secretion (GO:0046928)2.55812646
91suckling behavior (GO:0001967)2.55599881
92cell communication by electrical coupling (GO:0010644)2.55583113
93long-term synaptic potentiation (GO:0060291)2.55164308
94nucleus localization (GO:0051647)2.54382606
95protein localization to microtubule (GO:0035372)2.53511049
96positive regulation of synapse maturation (GO:0090129)2.53088896
97clathrin coat assembly (GO:0048268)2.52559820
98camera-type eye morphogenesis (GO:0048593)2.52303888
99dendritic spine organization (GO:0097061)2.51911784
100regulation of dendritic spine development (GO:0060998)2.51349012
101body morphogenesis (GO:0010171)2.50949313
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50421219
103histone H3-K36 demethylation (GO:0070544)2.49450864
104pericardium development (GO:0060039)2.49378502
105regulation of neurotransmitter levels (GO:0001505)2.48826828
106synapse assembly (GO:0007416)2.48025128
107chromosome organization involved in meiosis (GO:0070192)2.45300012
108neurotransmitter-gated ion channel clustering (GO:0072578)2.45036530
109cytoplasmic mRNA processing body assembly (GO:0033962)2.44494801
110regulation of synaptic transmission, glutamatergic (GO:0051966)2.44350991
111L-amino acid import (GO:0043092)2.44348391
112potassium ion homeostasis (GO:0055075)2.42615052
113positive regulation of dendritic spine development (GO:0060999)2.42533939
114postsynaptic membrane organization (GO:0001941)2.42340390
115regulation of vesicle fusion (GO:0031338)2.41865711
116axon extension (GO:0048675)2.40338029
117calcium ion-dependent exocytosis (GO:0017156)2.40289886
118regulation of clathrin-mediated endocytosis (GO:2000369)2.39744702
119membrane hyperpolarization (GO:0060081)2.39437905
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.39302795
121auditory behavior (GO:0031223)2.39301990
122embryonic foregut morphogenesis (GO:0048617)2.39147505
123hippo signaling (GO:0035329)2.38457442
124social behavior (GO:0035176)2.37976187
125intraspecies interaction between organisms (GO:0051703)2.37976187
126cerebral cortex radially oriented cell migration (GO:0021799)2.35571781
127regulation of Rac protein signal transduction (GO:0035020)2.34265071
128negative regulation of dendrite morphogenesis (GO:0050774)2.32783577
129myoblast fusion (GO:0007520)2.29990537
130artery development (GO:0060840)2.29266493
131kidney mesenchyme development (GO:0072074)2.25956985
132myelination in peripheral nervous system (GO:0022011)2.25435835
133peripheral nervous system axon ensheathment (GO:0032292)2.25435835
134regulation of histone H3-K9 methylation (GO:0051570)2.24744020
135metanephric mesenchyme development (GO:0072075)2.24378735
136negative regulation of histone methylation (GO:0031061)2.24360913
137planar cell polarity pathway involved in neural tube closure (GO:0090179)2.24094008
138pre-miRNA processing (GO:0031054)2.23980150
139cranial nerve morphogenesis (GO:0021602)2.22684260
140neuron projection extension (GO:1990138)2.21922964
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.21474224
142synaptonemal complex assembly (GO:0007130)2.21237171
143genitalia morphogenesis (GO:0035112)2.19558697
144asymmetric protein localization (GO:0008105)2.19162374
145regulation of axon extension involved in axon guidance (GO:0048841)2.19097213
146central nervous system neuron axonogenesis (GO:0021955)2.17403883
147piRNA metabolic process (GO:0034587)2.17102634
148regulation of RNA export from nucleus (GO:0046831)2.17084079
149pore complex assembly (GO:0046931)2.16598755
150interkinetic nuclear migration (GO:0022027)2.14001591
151negative regulation of inclusion body assembly (GO:0090084)2.13958671
152DNA packaging (GO:0006323)2.13120773
153developmental cell growth (GO:0048588)2.11967866
154negative regulation of keratinocyte proliferation (GO:0010839)2.11947778
155negative regulation of DNA repair (GO:0045738)2.11298753
156positive regulation of catenin import into nucleus (GO:0035413)2.10333112
157heart morphogenesis (GO:0003007)2.09798265
158negative regulation of vascular permeability (GO:0043116)2.09321844
159glucocorticoid receptor signaling pathway (GO:0042921)2.08297798
160embryonic camera-type eye morphogenesis (GO:0048596)2.08146615
161regulation of axon guidance (GO:1902667)2.07744316
162meiotic chromosome segregation (GO:0045132)2.05689062
163chromosome condensation (GO:0030261)2.05659705
164protein localization to microtubule cytoskeleton (GO:0072698)2.04562016
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.03832584
166male meiosis (GO:0007140)2.02068518
167regulation of centriole replication (GO:0046599)2.00760773
168cerebral cortex development (GO:0021987)2.00091523
169gastrulation with mouth forming second (GO:0001702)1.99969566
170eye morphogenesis (GO:0048592)1.98830597
171anterior/posterior axis specification, embryo (GO:0008595)1.97913919
172negative regulation of neurotransmitter secretion (GO:0046929)1.97648219
173insulin-like growth factor receptor signaling pathway (GO:0048009)1.97219695
174establishment of planar polarity (GO:0001736)1.96698729
175establishment of tissue polarity (GO:0007164)1.96698729
176negative chemotaxis (GO:0050919)1.95064048
177synaptonemal complex organization (GO:0070193)1.94982989
178neuron remodeling (GO:0016322)1.94257462
179proximal/distal pattern formation (GO:0009954)1.94052470
180mitotic chromosome condensation (GO:0007076)1.93855723
181protein localization to cytoskeleton (GO:0044380)1.92959135
182convergent extension (GO:0060026)1.92552532
183coronary vasculature morphogenesis (GO:0060977)1.91986900
184positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)1.91981394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74756857
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.13470594
3GBX2_23144817_ChIP-Seq_PC3_Human2.71203994
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63686065
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57899759
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55347413
7DROSHA_22980978_ChIP-Seq_HELA_Human2.42135461
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40837510
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40837510
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26687330
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23520762
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19896006
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19280197
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15329667
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.14829496
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14692134
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11320421
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09653946
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.04943107
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04817163
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.01670546
22REST_21632747_ChIP-Seq_MESCs_Mouse2.00221803
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.98176758
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.90477255
25* EED_16625203_ChIP-ChIP_MESCs_Mouse1.85824846
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83433139
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81331323
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80504756
29* FUS_26573619_Chip-Seq_HEK293_Human1.79251815
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64016884
31AR_21572438_ChIP-Seq_LNCaP_Human1.63399472
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59515150
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58433370
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56723129
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51493370
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50609199
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49947497
38* REST_18959480_ChIP-ChIP_MESCs_Mouse1.47893492
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46711539
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45405541
41ZNF274_21170338_ChIP-Seq_K562_Hela1.44920569
42TAF15_26573619_Chip-Seq_HEK293_Human1.43857771
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43046910
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42670972
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.42618881
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42115333
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40233188
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38487677
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37141910
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36620074
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35062766
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34902272
53E2F7_22180533_ChIP-Seq_HELA_Human1.34637898
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34404334
55SOX9_26525672_Chip-Seq_HEART_Mouse1.33461254
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32576402
57CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31728128
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.31701577
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31041152
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29690185
61* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29299456
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28940782
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.28771472
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.28043160
65AHR_22903824_ChIP-Seq_MCF-7_Human1.27528591
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.24347843
67* KDM2B_26808549_Chip-Seq_K562_Human1.24292581
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23478184
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22550756
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22546808
71AR_19668381_ChIP-Seq_PC3_Human1.22188810
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21683589
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21603445
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21284425
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20985465
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20437312
77* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19689640
78* STAT3_23295773_ChIP-Seq_U87_Human1.19331108
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18668994
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16931674
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.16631361
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16418940
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.16338428
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16114482
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12997089
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12348935
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12042784
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.11700021
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.11343542
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.09755288
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09729895
92P300_19829295_ChIP-Seq_ESCs_Human1.09455938
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.09348852
94* TCF4_23295773_ChIP-Seq_U87_Human1.09283058
95AR_25329375_ChIP-Seq_VCAP_Human1.08671441
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08609634
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.07965936
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07784578
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.07681878
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07118334
101* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07094690
102* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06632028
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06596045
104TP53_18474530_ChIP-ChIP_U2OS_Human1.06309978
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05828313
106BRD4_25478319_ChIP-Seq_HGPS_Human1.05761578
107EWS_26573619_Chip-Seq_HEK293_Human1.05440204
108TP53_16413492_ChIP-PET_HCT116_Human1.05092595
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05004444
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05004444
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.04950332
112* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01591115
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01511430
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00387674
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99832502
116EP300_21415370_ChIP-Seq_HL-1_Mouse0.99733240
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99097407
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98056012
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97457797
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96309016
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.95767104
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95383697
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95078899
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94939388
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92698533
126* ISL1_27105846_Chip-Seq_CPCs_Mouse0.91989468
127BCAT_22108803_ChIP-Seq_LS180_Human0.90976068
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90953535
129* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90891455
130BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90656181
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90355379
132RNF2_27304074_Chip-Seq_NSC_Mouse0.89568330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47269938
2MP0003880_abnormal_central_pattern3.79160098
3MP0003635_abnormal_synaptic_transmissio3.66943367
4MP0004270_analgesia3.50706751
5MP0002063_abnormal_learning/memory/cond2.77188871
6MP0009046_muscle_twitch2.74186564
7MP0009745_abnormal_behavioral_response2.73304690
8MP0002064_seizures2.70948624
9MP0005423_abnormal_somatic_nervous2.68829513
10MP0002572_abnormal_emotion/affect_behav2.38438193
11MP0000569_abnormal_digit_pigmentation2.31454443
12MP0001486_abnormal_startle_reflex2.30079124
13MP0008877_abnormal_DNA_methylation2.25448615
14MP0000778_abnormal_nervous_system2.21593530
15MP0002272_abnormal_nervous_system2.20539703
16MP0002734_abnormal_mechanical_nocicepti2.18782482
17MP0008057_abnormal_DNA_replication2.16201470
18MP0001968_abnormal_touch/_nociception2.09631680
19MP0009780_abnormal_chondrocyte_physiolo2.09512676
20MP0001440_abnormal_grooming_behavior2.04201499
21MP0004145_abnormal_muscle_electrophysio2.00167886
22MP0008569_lethality_at_weaning1.95831987
23MP0002735_abnormal_chemical_nociception1.85768810
24MP0004885_abnormal_endolymph1.83164624
25MP0002067_abnormal_sensory_capabilities1.82931126
26MP0002184_abnormal_innervation1.81712372
27MP0001501_abnormal_sleep_pattern1.80217049
28MP0008438_abnormal_cutaneous_collagen1.77202272
29MP0003329_amyloid_beta_deposits1.75677214
30MP0003937_abnormal_limbs/digits/tail_de1.71808250
31MP0002909_abnormal_adrenal_gland1.69182407
32MP0002557_abnormal_social/conspecific_i1.68375095
33MP0003705_abnormal_hypodermis_morpholog1.63264200
34MP0002733_abnormal_thermal_nociception1.62811453
35MP0004811_abnormal_neuron_physiology1.62055140
36MP0000955_abnormal_spinal_cord1.61311451
37MP0003890_abnormal_embryonic-extraembry1.56240423
38MP0005410_abnormal_fertilization1.55645374
39MP0000579_abnormal_nail_morphology1.55083104
40MP0003787_abnormal_imprinting1.54464468
41MP0008961_abnormal_basal_metabolism1.52892179
42MP0001970_abnormal_pain_threshold1.52547842
43MP0000751_myopathy1.50169750
44MP0004858_abnormal_nervous_system1.49947981
45MP0003942_abnormal_urinary_system1.49497703
46MP0003122_maternal_imprinting1.47934916
47MP0002882_abnormal_neuron_morphology1.47279046
48MP0000566_synostosis1.46570422
49MP0002736_abnormal_nociception_after1.46210825
50MP0010030_abnormal_orbit_morphology1.42107798
51MP0005386_behavior/neurological_phenoty1.41850860
52MP0004924_abnormal_behavior1.41850860
53MP0005503_abnormal_tendon_morphology1.39675484
54MP0000428_abnormal_craniofacial_morphol1.38867550
55MP0005623_abnormal_meninges_morphology1.38573476
56MP0004742_abnormal_vestibular_system1.38265793
57MP0009250_abnormal_appendicular_skeleto1.36894870
58MP0002066_abnormal_motor_capabilities/c1.33606863
59MP0000383_abnormal_hair_follicle1.33479362
60MP0010368_abnormal_lymphatic_system1.31351528
61MP0004272_abnormal_basement_membrane1.31193250
62MP0010352_gastrointestinal_tract_polyps1.29924532
63MP0009053_abnormal_anal_canal1.28572496
64MP0002152_abnormal_brain_morphology1.27690510
65MP0002084_abnormal_developmental_patter1.26458483
66MP0003935_abnormal_craniofacial_develop1.25135367
67MP0001984_abnormal_olfaction1.21834159
68MP0003121_genomic_imprinting1.19610928
69MP0003633_abnormal_nervous_system1.19112636
70MP0006276_abnormal_autonomic_nervous1.18889779
71MP0002233_abnormal_nose_morphology1.18232174
72MP0000920_abnormal_myelination1.17023080
73MP0005275_abnormal_skin_tensile1.16287006
74MP0003755_abnormal_palate_morphology1.15506194
75MP0009703_decreased_birth_body1.15352239
76MP0003941_abnormal_skin_development1.13589939
77MP0010678_abnormal_skin_adnexa1.13037450
78MP0002697_abnormal_eye_size1.12451642
79MP0001502_abnormal_circadian_rhythm1.12395282
80MP0003123_paternal_imprinting1.10891930
81MP0003879_abnormal_hair_cell1.10642504
82MP0000432_abnormal_head_morphology1.09539614
83MP0001188_hyperpigmentation1.06964061
84MP0002822_catalepsy1.06765997
85MP0003303_peritoneal_inflammation1.06484256
86MP0003631_nervous_system_phenotype1.04645729
87MP0003634_abnormal_glial_cell1.03201119
88MP0001299_abnormal_eye_distance/1.02759786
89MP0002249_abnormal_larynx_morphology1.02429567
90MP0005551_abnormal_eye_electrophysiolog1.02242765
91MP0009672_abnormal_birth_weight1.01884004
92MP0003115_abnormal_respiratory_system1.00632480
93MP0002837_dystrophic_cardiac_calcinosis1.00629220
94MP0002108_abnormal_muscle_morphology1.00535216
95MP0002116_abnormal_craniofacial_bone1.00501295
96MP0003119_abnormal_digestive_system0.98498251
97MP0004233_abnormal_muscle_weight0.98413051
98MP0002085_abnormal_embryonic_tissue0.98024704
99MP0003283_abnormal_digestive_organ0.97791086
100MP0002229_neurodegeneration0.97403142
101MP0002114_abnormal_axial_skeleton0.96839153
102MP0005645_abnormal_hypothalamus_physiol0.95971456
103MP0003045_fibrosis0.94531808
104MP0002081_perinatal_lethality0.94270318
105MP0001958_emphysema0.93596076
106MP0000013_abnormal_adipose_tissue0.93371624
107MP0000534_abnormal_ureter_morphology0.91182324
108MP0005409_darkened_coat_color0.90268400
109MP0002160_abnormal_reproductive_system0.90126703
110MP0000733_abnormal_muscle_development0.88504757
111MP0003632_abnormal_nervous_system0.88214855
112MP0004510_myositis0.87988868
113MP0002234_abnormal_pharynx_morphology0.87900904
114MP0004085_abnormal_heartbeat0.87480823
115MP0001879_abnormal_lymphatic_vessel0.87055856
116MP0002069_abnormal_eating/drinking_beha0.86437067
117MP0005248_abnormal_Harderian_gland0.85881501
118MP0003861_abnormal_nervous_system0.85776558
119MP0002177_abnormal_outer_ear0.85566325
120MP0005257_abnormal_intraocular_pressure0.85364889
121MP0005187_abnormal_penis_morphology0.85328865
122MP0000747_muscle_weakness0.84477504
123MP0001286_abnormal_eye_development0.84245626
124MP0004134_abnormal_chest_morphology0.84117275
125MP0002752_abnormal_somatic_nervous0.83153944
126MP0003385_abnormal_body_wall0.82877844
127MP0005394_taste/olfaction_phenotype0.82820529
128MP0005499_abnormal_olfactory_system0.82820529
129MP0005646_abnormal_pituitary_gland0.82709631
130* MP0002210_abnormal_sex_determination0.81767876
131MP0000631_abnormal_neuroendocrine_gland0.81622744
132MP0010386_abnormal_urinary_bladder0.80295507
133MP0003690_abnormal_glial_cell0.79211270
134* MP0001929_abnormal_gametogenesis0.78885865
135MP0001963_abnormal_hearing_physiology0.78564314
136MP0006072_abnormal_retinal_apoptosis0.78178464
137MP0000762_abnormal_tongue_morphology0.77195964
138MP0003566_abnormal_cell_adhesion0.76874067
139MP0000462_abnormal_digestive_system0.76190179
140MP0005076_abnormal_cell_differentiation0.75746290
141MP0001905_abnormal_dopamine_level0.75488461
142MP0000003_abnormal_adipose_tissue0.75284894
143MP0002896_abnormal_bone_mineralization0.75099529
144MP0003943_abnormal_hepatobiliary_system0.74814549
145MP0002653_abnormal_ependyma_morphology0.74779787
146MP0002109_abnormal_limb_morphology0.74508369
147MP0001293_anophthalmia0.74205273
148MP0001943_abnormal_respiration0.73718263
149MP0002925_abnormal_cardiovascular_devel0.73365947
150MP0004130_abnormal_muscle_cell0.73187262
151MP0004484_altered_response_of0.72887503
152MP0002938_white_spotting0.72813322
153MP0003984_embryonic_growth_retardation0.71790681
154MP0002877_abnormal_melanocyte_morpholog0.71433022
155MP0000537_abnormal_urethra_morphology0.68929689
156MP0000604_amyloidosis0.68779405
157MP0008874_decreased_physiological_sensi0.68423530
158MP0004142_abnormal_muscle_tone0.67669374
159* MP0003698_abnormal_male_reproductive0.65863735
160MP0010769_abnormal_survival0.65824477
161MP0010770_preweaning_lethality0.65261300
162MP0002082_postnatal_lethality0.65261300
163MP0001177_atelectasis0.64083690

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.80331249
2Focal seizures (HP:0007359)4.16688862
3Visual hallucinations (HP:0002367)3.73778425
4Volvulus (HP:0002580)3.63884037
5Supranuclear gaze palsy (HP:0000605)3.63203142
6Myokymia (HP:0002411)3.45707251
7Progressive cerebellar ataxia (HP:0002073)3.41151217
8Atonic seizures (HP:0010819)3.40922438
9Epileptic encephalopathy (HP:0200134)3.29810624
10Genetic anticipation (HP:0003743)3.06182106
11Action tremor (HP:0002345)3.00816789
12Absent/shortened dynein arms (HP:0200106)2.95173173
13Dynein arm defect of respiratory motile cilia (HP:0012255)2.95173173
14Broad-based gait (HP:0002136)2.93588103
15Cerebral inclusion bodies (HP:0100314)2.93048501
16Absence seizures (HP:0002121)2.87122250
17Febrile seizures (HP:0002373)2.86423045
18Urinary bladder sphincter dysfunction (HP:0002839)2.76955827
19Neurofibrillary tangles (HP:0002185)2.72159401
20Ankle clonus (HP:0011448)2.56534597
21Insidious onset (HP:0003587)2.53541192
22Termporal pattern (HP:0011008)2.53541192
23Gaze-evoked nystagmus (HP:0000640)2.53352828
24Dialeptic seizures (HP:0011146)2.52714967
25Excessive salivation (HP:0003781)2.52066270
26Drooling (HP:0002307)2.52066270
27Hyperventilation (HP:0002883)2.49633253
28Truncal ataxia (HP:0002078)2.47549062
29Diplopia (HP:0000651)2.47431002
30Abnormality of binocular vision (HP:0011514)2.47431002
31Absent speech (HP:0001344)2.46640472
32Papillary thyroid carcinoma (HP:0002895)2.46588730
33Generalized tonic-clonic seizures (HP:0002069)2.45927667
34Buphthalmos (HP:0000557)2.45758109
35Hemiplegia (HP:0002301)2.44053630
36Overgrowth (HP:0001548)2.43797391
37Truncal obesity (HP:0001956)2.42895531
38Abnormality of the corticospinal tract (HP:0002492)2.42882542
39Impaired vibration sensation in the lower limbs (HP:0002166)2.42205307
40Urinary urgency (HP:0000012)2.40685311
41Dysmetria (HP:0001310)2.39985859
42Amblyopia (HP:0000646)2.39740089
43Neonatal short-limb short stature (HP:0008921)2.37258364
44Hemiparesis (HP:0001269)2.37242405
45Papilledema (HP:0001085)2.35346024
46Spastic gait (HP:0002064)2.32947862
47Vertebral arch anomaly (HP:0008438)2.32382414
48Depression (HP:0000716)2.27999958
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25679456
50Protrusio acetabuli (HP:0003179)2.25330972
51Increased nuchal translucency (HP:0010880)2.25326454
52Postural instability (HP:0002172)2.25137045
53Dysdiadochokinesis (HP:0002075)2.25005708
54Macroorchidism (HP:0000053)2.24237957
55Abnormality of the ischium (HP:0003174)2.22095940
56Dysmetric saccades (HP:0000641)2.19622316
57Impaired smooth pursuit (HP:0007772)2.11757740
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11743338
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.11743338
60Abnormality of dentin (HP:0010299)2.11736138
61Impaired social interactions (HP:0000735)2.11230106
62Abnormal social behavior (HP:0012433)2.11230106
63Broad metatarsal (HP:0001783)2.10174747
64Hypoplastic ischia (HP:0003175)2.06715285
65Heterotopia (HP:0002282)2.05181399
66Agitation (HP:0000713)2.05177720
67Widely spaced teeth (HP:0000687)2.04649609
68Poor eye contact (HP:0000817)2.04633584
69Arterial tortuosity (HP:0005116)2.04308167
70Vascular tortuosity (HP:0004948)2.02860950
71Stereotypic behavior (HP:0000733)2.02587865
72Neuronal loss in central nervous system (HP:0002529)2.02144830
73Premature rupture of membranes (HP:0001788)2.00578683
74Mild short stature (HP:0003502)1.99347159
75Aqueductal stenosis (HP:0002410)1.99171101
76Atrophic scars (HP:0001075)1.98568231
77Abnormal respiratory motile cilium physiology (HP:0012261)1.98459166
78Scanning speech (HP:0002168)1.98174635
79Mutism (HP:0002300)1.97671647
80Abnormality of the lower motor neuron (HP:0002366)1.95786630
81Insomnia (HP:0100785)1.93681756
82Abnormality of ocular smooth pursuit (HP:0000617)1.93408722
83Abnormal eating behavior (HP:0100738)1.92149366
84Lower limb muscle weakness (HP:0007340)1.87174853
85Ectopic kidney (HP:0000086)1.86059970
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85064331
87Pointed chin (HP:0000307)1.84823973
88Hypoventilation (HP:0002791)1.84265569
89Wide anterior fontanel (HP:0000260)1.84097108
90Neoplasm of the heart (HP:0100544)1.83694716
91Intention tremor (HP:0002080)1.83380514
92Abnormal ciliary motility (HP:0012262)1.83074892
93Cutaneous finger syndactyly (HP:0010554)1.82164029
94Hepatoblastoma (HP:0002884)1.82156584
95Open mouth (HP:0000194)1.81878724
96Exotropia (HP:0000577)1.81625354
97Abnormality of chromosome segregation (HP:0002916)1.81262901
98Rapidly progressive (HP:0003678)1.81158637
99Cubitus valgus (HP:0002967)1.80117038
100Shallow orbits (HP:0000586)1.78116501
101Long eyelashes (HP:0000527)1.76456939
102Bowel diverticulosis (HP:0005222)1.76281833
103Difficulty running (HP:0009046)1.74336256
104Anxiety (HP:0000739)1.73418177
105Abnormality of the phalanges of the hallux (HP:0010057)1.72836972
106High anterior hairline (HP:0009890)1.71580140
107Megalencephaly (HP:0001355)1.70717904
108Coronal craniosynostosis (HP:0004440)1.70464728
109Inappropriate behavior (HP:0000719)1.70193401
110Amyotrophic lateral sclerosis (HP:0007354)1.69983135
111Epileptiform EEG discharges (HP:0011182)1.69355548
112Obstructive sleep apnea (HP:0002870)1.69074081
113Hyperacusis (HP:0010780)1.68803297
114EEG with generalized epileptiform discharges (HP:0011198)1.68522477
115Mitral valve prolapse (HP:0001634)1.68461410
116Narrow palate (HP:0000189)1.68222107
117Exercise-induced myalgia (HP:0003738)1.68190112
118Broad long bones (HP:0005622)1.67445452
119Intellectual disability, moderate (HP:0002342)1.66050796
120Abnormality of salivation (HP:0100755)1.64978912
121Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63434580
122Bell-shaped thorax (HP:0001591)1.61986817
123Renovascular hypertension (HP:0100817)1.60924620
124Abnormal respiratory epithelium morphology (HP:0012253)1.60540996
125Abnormal respiratory motile cilium morphology (HP:0005938)1.60540996
126Abnormality of saccadic eye movements (HP:0000570)1.59913779
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.59469210
128Congenital glaucoma (HP:0001087)1.59213661
129Hypsarrhythmia (HP:0002521)1.59170274
130Cutaneous syndactyly (HP:0012725)1.58899044
131Lower limb amyotrophy (HP:0007210)1.58470444
132Aplasia/Hypoplasia of the brainstem (HP:0007362)1.58192294
133Hypoplasia of the brainstem (HP:0002365)1.58192294
134Obsessive-compulsive behavior (HP:0000722)1.57204209
135Bradykinesia (HP:0002067)1.56915863
136Limited elbow extension (HP:0001377)1.56822457
137Thickened helices (HP:0000391)1.56756426
138Apathy (HP:0000741)1.56709928
139Genu recurvatum (HP:0002816)1.56480637
140Ulnar bowing (HP:0003031)1.56098895
141Hypoplastic labia majora (HP:0000059)1.55090076
142Broad phalanx (HP:0006009)1.55069539
143Elfin facies (HP:0004428)1.55058944
144Midline defect of the nose (HP:0004122)1.54830090
145Abnormality of the antihelix (HP:0009738)1.54130722
146Bladder diverticulum (HP:0000015)1.54033052
147Pulmonic stenosis (HP:0001642)1.52806968
148Aortic dissection (HP:0002647)1.51955490
149Turricephaly (HP:0000262)1.51663913
150Synophrys (HP:0000664)1.51529503
151Absent frontal sinuses (HP:0002688)1.51456766
152Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.50440762
153Short 4th metacarpal (HP:0010044)1.50440762
154Omphalocele (HP:0001539)1.48461416
155Smooth philtrum (HP:0000319)1.48102753
156Broad finger (HP:0001500)1.48042292
157Abnormality of the astrocytes (HP:0100707)1.46883196
158Astrocytoma (HP:0009592)1.46883196
159Relative macrocephaly (HP:0004482)1.45986362
160Abnormality of the calcaneus (HP:0008364)1.45840058
161Abnormality of the epiphyses of the hand (HP:0005924)1.44508366
162Deep philtrum (HP:0002002)1.44343432
163Short palm (HP:0004279)1.44337891
164Broad thumb (HP:0011304)1.43791531
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.42208177
166Preaxial foot polydactyly (HP:0001841)1.41168492
167Osteomalacia (HP:0002749)1.40723746
168Abnormality of the aortic arch (HP:0012303)1.40711147
169Aplasia involving bones of the extremities (HP:0009825)1.40386108
170Aplasia involving bones of the upper limbs (HP:0009823)1.40386108
171Aplasia of the phalanges of the hand (HP:0009802)1.40386108
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.40111329
173Thick eyebrow (HP:0000574)1.39811679
174Resting tremor (HP:0002322)1.39583556
175Oligodactyly (hands) (HP:0001180)1.39494274
176Abnormality of the labia majora (HP:0012881)1.39472714
177Shawl scrotum (HP:0000049)1.39097906
178Deviation of the hallux (HP:0010051)1.39090830
179Rhizomelia (HP:0008905)1.39068239
180Calcaneovalgus deformity (HP:0001848)1.37667102
181Overriding aorta (HP:0002623)1.37428411
182Laryngomalacia (HP:0001601)1.37321489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.25396238
2MAP3K42.89079606
3MARK12.86103710
4MAP3K92.77559696
5SIK22.52653700
6MET2.31174874
7EPHA42.30349000
8PRKD32.28804380
9NTRK22.25028412
10* PNCK2.11129105
11AKT32.09298602
12PAK62.03237397
13MINK11.96519272
14MAP2K71.91847341
15ICK1.89962518
16MAP2K41.82928470
17MAP3K101.77972388
18DAPK21.64113196
19NTRK11.56896999
20RIPK41.55240907
21FES1.53019015
22LATS11.51743061
23WNK11.49194467
24TYRO31.44873837
25KSR21.44864500
26CAMKK11.37989182
27MARK21.37859385
28PLK41.35038832
29CDK51.33584096
30TAF11.31493848
31NEK91.30516736
32KSR11.28901665
33* CAMK1G1.28842211
34CAMK1D1.28842211
35PHKG21.26749864
36PHKG11.26749864
37UHMK11.23078483
38STK381.22580888
39MKNK21.21356550
40PTK2B1.21219591
41DMPK1.19899833
42STK391.15176211
43WNK41.14930020
44STK38L1.13557408
45MAPK131.13336641
46STK111.13308095
47PRKCH1.09063633
48FGFR21.08832403
49MTOR1.06882962
50RET1.06391311
51PAK31.03831782
52PLK21.01590798
53TTK1.00923757
54CSNK1G20.96516550
55RIPK10.95413848
56BMX0.93189439
57SGK2230.92614318
58SGK4940.92614318
59CDK30.92317923
60CASK0.92167119
61DDR20.87846940
62EPHB10.87136257
63ALK0.86829702
64BRAF0.86434719
65PRKCG0.85962430
66EPHB20.84743434
67SGK30.83326402
68TAOK10.83178871
69OXSR10.83068275
70CSNK1A1L0.82268332
71STK30.81412995
72PAK20.80446057
73SGK10.79313026
74MAP3K20.78959473
75MAP3K70.78400518
76MKNK10.77009095
77CSNK1E0.76213192
78ROCK10.75963747
79PKN10.74956620
80CDC42BPA0.74942039
81CHEK10.74568450
82WEE10.73620001
83CAMK2A0.73408652
84SGK20.73213944
85ATM0.72829468
86TAOK30.72164534
87MAP3K130.72068065
88YES10.68255158
89EEF2K0.67794468
90FYN0.67323374
91TNIK0.66658756
92STK240.66539041
93ROCK20.66478843
94FGFR10.65438047
95RPS6KB10.65217258
96TRIB30.65152981
97MAP3K120.63881155
98MAPK120.63825613
99BRD40.63471682
100DYRK1A0.62756807
101RPS6KA20.62343740
102PDGFRA0.62218080
103CAMKK20.62082959
104PDK10.61261973
105FGR0.61102806
106PTK20.61065597
107PDGFRB0.60612826
108GRK50.59552789
109DAPK10.59453549
110CDK90.59331354
111CDK150.58588050
112LATS20.57653814
113BRSK20.57310987
114PRKDC0.57199918
115CDK180.56963329
116CDC70.56952785
117MAPK100.56117563
118FRK0.56050422
119CDK140.55950085
120RPS6KA30.55715160
121TNK20.54910021
122HIPK20.54729052
123PDPK10.54598987
124ATR0.54126004
125* CAMK10.53926396
126CSNK1G30.53432407
127CAMK2B0.53409411
128CDK10.52927854
129GSK3B0.52829367
130CDK11A0.50948019
131PRKD20.49363846
132MAP3K10.49096854
133ERBB40.48785714
134CAMK40.48196597
135PRKCZ0.47843533
136MAPK140.46613265
137CDK120.46535090
138CDK20.46090886
139PRKCE0.46006287
140INSRR0.44258725
141CDK190.43706185
142ARAF0.42699499
143PLK30.42485943
144CHEK20.41502616
145PRKAA10.40743053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.55693152
2Long-term potentiation_Homo sapiens_hsa047202.23525410
3Synaptic vesicle cycle_Homo sapiens_hsa047212.18659820
4Circadian entrainment_Homo sapiens_hsa047132.14834975
5Glutamatergic synapse_Homo sapiens_hsa047242.08609348
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08022820
7GABAergic synapse_Homo sapiens_hsa047271.99004110
8Amphetamine addiction_Homo sapiens_hsa050311.95080931
9Morphine addiction_Homo sapiens_hsa050321.90783087
10Olfactory transduction_Homo sapiens_hsa047401.90004336
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89947204
12Salivary secretion_Homo sapiens_hsa049701.87851111
13Adherens junction_Homo sapiens_hsa045201.83899816
14Dopaminergic synapse_Homo sapiens_hsa047281.79889721
15ECM-receptor interaction_Homo sapiens_hsa045121.79321305
16Insulin secretion_Homo sapiens_hsa049111.77603846
17Gastric acid secretion_Homo sapiens_hsa049711.75006768
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71169310
19Cholinergic synapse_Homo sapiens_hsa047251.62228229
20Renin secretion_Homo sapiens_hsa049241.61217966
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57425360
22Long-term depression_Homo sapiens_hsa047301.55646560
23Taste transduction_Homo sapiens_hsa047421.52836349
24Oxytocin signaling pathway_Homo sapiens_hsa049211.49771673
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49695971
26Lysine degradation_Homo sapiens_hsa003101.48724117
27Dorso-ventral axis formation_Homo sapiens_hsa043201.48407444
28Cocaine addiction_Homo sapiens_hsa050301.48337360
29Hippo signaling pathway_Homo sapiens_hsa043901.42896444
30Axon guidance_Homo sapiens_hsa043601.41929122
31Type II diabetes mellitus_Homo sapiens_hsa049301.38797475
32Serotonergic synapse_Homo sapiens_hsa047261.35186629
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35042034
34Basal cell carcinoma_Homo sapiens_hsa052171.32446616
35Estrogen signaling pathway_Homo sapiens_hsa049151.32306890
36GnRH signaling pathway_Homo sapiens_hsa049121.30631136
37Prostate cancer_Homo sapiens_hsa052151.29929459
38Calcium signaling pathway_Homo sapiens_hsa040201.28888852
39Glioma_Homo sapiens_hsa052141.22899113
40Gap junction_Homo sapiens_hsa045401.21493631
41cAMP signaling pathway_Homo sapiens_hsa040241.21141162
42MicroRNAs in cancer_Homo sapiens_hsa052061.20752854
43Tight junction_Homo sapiens_hsa045301.20165814
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18577602
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17415533
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15406096
47mRNA surveillance pathway_Homo sapiens_hsa030151.15145571
48TGF-beta signaling pathway_Homo sapiens_hsa043501.14982333
49Cell cycle_Homo sapiens_hsa041101.14335049
50ErbB signaling pathway_Homo sapiens_hsa040121.13014085
51Melanoma_Homo sapiens_hsa052181.11631363
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08905143
53Melanogenesis_Homo sapiens_hsa049161.08301211
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07469409
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04123401
56Dilated cardiomyopathy_Homo sapiens_hsa054140.99924476
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.98104471
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97830861
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96595509
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95207163
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.95050552
62Collecting duct acid secretion_Homo sapiens_hsa049660.93356879
63Fatty acid biosynthesis_Homo sapiens_hsa000610.92116317
64Phototransduction_Homo sapiens_hsa047440.91913040
65Renal cell carcinoma_Homo sapiens_hsa052110.91472839
66Choline metabolism in cancer_Homo sapiens_hsa052310.90412261
67Thyroid hormone synthesis_Homo sapiens_hsa049180.89147320
68Circadian rhythm_Homo sapiens_hsa047100.88204765
69MAPK signaling pathway_Homo sapiens_hsa040100.87781596
70Pancreatic secretion_Homo sapiens_hsa049720.87570572
71VEGF signaling pathway_Homo sapiens_hsa043700.86896100
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.86544697
73Non-homologous end-joining_Homo sapiens_hsa034500.85191461
74Small cell lung cancer_Homo sapiens_hsa052220.85095474
75Thyroid cancer_Homo sapiens_hsa052160.84798034
76AMPK signaling pathway_Homo sapiens_hsa041520.84343043
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84092442
78Amoebiasis_Homo sapiens_hsa051460.84091964
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.84025403
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83060997
81Glucagon signaling pathway_Homo sapiens_hsa049220.80810404
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77285109
83Protein digestion and absorption_Homo sapiens_hsa049740.76382321
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76173766
85Wnt signaling pathway_Homo sapiens_hsa043100.75275973
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75248344
87Notch signaling pathway_Homo sapiens_hsa043300.72850112
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72814017
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72618940
90Pathways in cancer_Homo sapiens_hsa052000.71956223
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71037277
92Endometrial cancer_Homo sapiens_hsa052130.70914390
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70603710
94Rap1 signaling pathway_Homo sapiens_hsa040150.69948870
95Cardiac muscle contraction_Homo sapiens_hsa042600.67130664
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66410947
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.65447480
98Ras signaling pathway_Homo sapiens_hsa040140.65290188
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64820935
100Non-small cell lung cancer_Homo sapiens_hsa052230.64529671
101Endocytosis_Homo sapiens_hsa041440.64261549
102mTOR signaling pathway_Homo sapiens_hsa041500.63116776
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62984886
104Hedgehog signaling pathway_Homo sapiens_hsa043400.61758660
105Oocyte meiosis_Homo sapiens_hsa041140.60753191
106B cell receptor signaling pathway_Homo sapiens_hsa046620.60216744
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60193535
108Vibrio cholerae infection_Homo sapiens_hsa051100.58921701
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58214465
110Inositol phosphate metabolism_Homo sapiens_hsa005620.58039968
111T cell receptor signaling pathway_Homo sapiens_hsa046600.57700403
112Colorectal cancer_Homo sapiens_hsa052100.57520418
113Focal adhesion_Homo sapiens_hsa045100.55334710
114Chemokine signaling pathway_Homo sapiens_hsa040620.54649593
115Insulin signaling pathway_Homo sapiens_hsa049100.53268420
116Platelet activation_Homo sapiens_hsa046110.51214556
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50700855
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49425016
119Chronic myeloid leukemia_Homo sapiens_hsa052200.49001500
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48819029
121Prolactin signaling pathway_Homo sapiens_hsa049170.48010147
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47630885
123Pancreatic cancer_Homo sapiens_hsa052120.47477211
124Proteoglycans in cancer_Homo sapiens_hsa052050.47454631
125Ovarian steroidogenesis_Homo sapiens_hsa049130.47393536
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45684546
127Nitrogen metabolism_Homo sapiens_hsa009100.43443346

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