EIF4HP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication-dependent nucleosome assembly (GO:0006335)6.72864080
2DNA replication-dependent nucleosome organization (GO:0034723)6.72864080
3negative regulation of B cell apoptotic process (GO:0002903)5.27101447
4innate immune response in mucosa (GO:0002227)5.20175125
5nucleosome assembly (GO:0006334)4.98117079
6positive regulation of prostaglandin secretion (GO:0032308)4.90493994
7DNA deamination (GO:0045006)4.71911243
8regulation of prostaglandin secretion (GO:0032306)4.63293504
9protein-DNA complex assembly (GO:0065004)4.45598517
10nucleosome organization (GO:0034728)4.36039754
11mucosal immune response (GO:0002385)4.30388645
12antibacterial humoral response (GO:0019731)4.21849716
13chromatin assembly (GO:0031497)4.13903217
14regulation of B cell apoptotic process (GO:0002902)4.01937490
15protein-DNA complex subunit organization (GO:0071824)4.00196678
16ribosome assembly (GO:0042255)3.87568064
17regulation of isotype switching to IgG isotypes (GO:0048302)3.86520762
18antimicrobial humoral response (GO:0019730)3.85155691
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77380089
20peptidyl-arginine omega-N-methylation (GO:0035247)3.76938327
21organ or tissue specific immune response (GO:0002251)3.76141594
22nuclear pore complex assembly (GO:0051292)3.74533168
23viral mRNA export from host cell nucleus (GO:0046784)3.72819866
24chaperone mediated protein folding requiring cofactor (GO:0051085)3.66683766
25peptidyl-arginine methylation (GO:0018216)3.64670120
26peptidyl-arginine N-methylation (GO:0035246)3.64670120
27positive regulation of T cell mediated cytotoxicity (GO:0001916)3.59675086
28positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.58668691
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49001133
30spermatid nucleus differentiation (GO:0007289)3.45397855
31microtubule depolymerization (GO:0007019)3.38643725
32tRNA modification (GO:0006400)3.35080725
33regulation of histone H3-K9 methylation (GO:0051570)3.35025297
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.30041176
35ribosome biogenesis (GO:0042254)3.27662469
36cytidine metabolic process (GO:0046087)3.27495278
37cytidine catabolic process (GO:0006216)3.27495278
38cytidine deamination (GO:0009972)3.27495278
39DNA strand elongation involved in DNA replication (GO:0006271)3.24114504
40nuclear pore organization (GO:0006999)3.22922192
41protein maturation by protein folding (GO:0022417)3.21965003
42regulation of immunoglobulin secretion (GO:0051023)3.18928651
43chromosome condensation (GO:0030261)3.17307272
44negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.14077092
45regulation of centriole replication (GO:0046599)3.11877285
46pseudouridine synthesis (GO:0001522)3.09847050
47immunoglobulin mediated immune response (GO:0016064)3.09387931
48DNA strand elongation (GO:0022616)3.06423685
49positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.04974448
50positive regulation of fatty acid transport (GO:2000193)3.00537299
51DNA packaging (GO:0006323)2.99982233
52regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.98428776
53chromatin assembly or disassembly (GO:0006333)2.97292707
54rRNA methylation (GO:0031167)2.96465258
55regulation of megakaryocyte differentiation (GO:0045652)2.95560149
56sperm motility (GO:0030317)2.95182207
57CENP-A containing nucleosome assembly (GO:0034080)2.89579768
58rRNA modification (GO:0000154)2.88733382
59B cell mediated immunity (GO:0019724)2.86075368
60negative regulation of lymphocyte apoptotic process (GO:0070229)2.85992997
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83194235
62regulation of mitochondrial translation (GO:0070129)2.83155900
63histone arginine methylation (GO:0034969)2.82644770
64T-helper 1 type immune response (GO:0042088)2.81292951
65positive regulation of icosanoid secretion (GO:0032305)2.81291209
66mismatch repair (GO:0006298)2.79717884
67regulation of T cell mediated cytotoxicity (GO:0001914)2.78382905
68positive regulation of humoral immune response (GO:0002922)2.77935270
69tRNA methylation (GO:0030488)2.73548029
70tRNA processing (GO:0008033)2.73241482
71histone exchange (GO:0043486)2.71697271
72protein polyglutamylation (GO:0018095)2.68852043
73DNA catabolic process, exonucleolytic (GO:0000738)2.68408324
74pore complex assembly (GO:0046931)2.63034009
75spliceosomal snRNP assembly (GO:0000387)2.62367367
76telomere maintenance via semi-conservative replication (GO:0032201)2.62152327
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.61828127
78chromatin remodeling at centromere (GO:0031055)2.61177536
79tRNA metabolic process (GO:0006399)2.59829532
80positive regulation of T cell mediated immunity (GO:0002711)2.59519744
81sperm-egg recognition (GO:0035036)2.58902800
82microtubule polymerization or depolymerization (GO:0031109)2.57442674
83DNA unwinding involved in DNA replication (GO:0006268)2.57417436
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.56909891
85proteasome assembly (GO:0043248)2.55176366
86pyrimidine ribonucleoside catabolic process (GO:0046133)2.52499956
87regulation of regulatory T cell differentiation (GO:0045589)2.49847597
88positive regulation of cell killing (GO:0031343)2.49580716
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.49198260
90binding of sperm to zona pellucida (GO:0007339)2.48657676
91negative T cell selection (GO:0043383)2.47338385
92telomere maintenance (GO:0000723)2.47055059
93RNA modification (GO:0009451)2.46860664
94cellular response to interferon-beta (GO:0035458)2.46519275
95pyrimidine nucleotide catabolic process (GO:0006244)2.46430163
96positive regulation of interleukin-17 production (GO:0032740)2.46210715
97regulation of interferon-gamma biosynthetic process (GO:0045072)2.45190867
98telomere organization (GO:0032200)2.43880447
99interkinetic nuclear migration (GO:0022027)2.43814213
100DNA replication initiation (GO:0006270)2.40908624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45431421
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.17044982
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.07950906
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39021344
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24113287
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74010378
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.62411134
8VDR_23849224_ChIP-Seq_CD4+_Human2.46778429
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.29004802
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22490970
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.21703018
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.19254877
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12414530
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11916688
15IRF1_19129219_ChIP-ChIP_H3396_Human2.08592984
16ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04576793
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.02574195
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.6634937
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94592332
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94565089
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90950384
22SOX2_16153702_ChIP-ChIP_HESCs_Human1.90376656
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88832328
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88290052
25ZNF274_21170338_ChIP-Seq_K562_Hela1.87023351
26ELK1_19687146_ChIP-ChIP_HELA_Human1.86076643
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.85715689
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.84868361
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82073263
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80988145
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.77514027
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74396076
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72677445
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.69833416
35MYC_18940864_ChIP-ChIP_HL60_Human1.68636626
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65441593
37FOXP3_21729870_ChIP-Seq_TREG_Human1.61657787
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59011920
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58705762
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52904329
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.51672992
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50791055
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48842808
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48674566
45CIITA_25753668_ChIP-Seq_RAJI_Human1.48439673
46CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.46907813
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46396442
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46093636
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45545599
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38763682
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37984958
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.37258044
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34663715
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33160018
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29554519
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27185185
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27020179
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26682788
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26651839
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.25320331
61DCP1A_22483619_ChIP-Seq_HELA_Human1.23177832
62TAF15_26573619_Chip-Seq_HEK293_Human1.21212027
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21079053
64XRN2_22483619_ChIP-Seq_HELA_Human1.19519917
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14503351
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14315942
67MYB_26560356_Chip-Seq_TH2_Human1.12758365
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09448098
69GABP_19822575_ChIP-Seq_HepG2_Human1.08563748
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06085606
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04684883
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01625061
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97112635
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96546962
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93033132
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92718900
77VDR_22108803_ChIP-Seq_LS180_Human0.92275575
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91913887
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90603068
80MYB_26560356_Chip-Seq_TH1_Human0.89603422
81TTF2_22483619_ChIP-Seq_HELA_Human0.89590906
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86748900
83GATA3_26560356_Chip-Seq_TH2_Human0.85329766
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84828302
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84533052
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83487845
87CBP_20019798_ChIP-Seq_JUKART_Human0.83487845
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81661711
89ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79789401
90NCOR_22424771_ChIP-Seq_293T_Human0.79749216
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.78518307
92GATA3_27048872_Chip-Seq_THYMUS_Human0.78035083
93ERG_20517297_ChIP-Seq_VCAP_Human0.74870006
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74688893
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74153174
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74148463
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72778450
98MAF_26560356_Chip-Seq_TH1_Human0.72432157
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.71154162
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70268343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.44617230
2MP0005410_abnormal_fertilization3.42913109
3MP0010094_abnormal_chromosome_stability3.26097395
4MP0004147_increased_porphyrin_level3.25802289
5MP0003693_abnormal_embryo_hatching3.17157582
6MP0009046_muscle_twitch3.01148608
7MP0008058_abnormal_DNA_repair2.94481979
8MP0003111_abnormal_nucleus_morphology2.77152901
9MP0001348_abnormal_lacrimal_gland2.67715327
10MP0001835_abnormal_antigen_presentation2.63273915
11MP0005671_abnormal_response_to2.56974263
12MP0008057_abnormal_DNA_replication2.36625670
13MP0003077_abnormal_cell_cycle2.35387346
14MP0000685_abnormal_immune_system2.29692833
15MP0003786_premature_aging2.20899499
16MP0004957_abnormal_blastocyst_morpholog2.20505579
17MP0008872_abnormal_physiological_respon1.99225625
18MP0005646_abnormal_pituitary_gland1.95441520
19MP0001727_abnormal_embryo_implantation1.88093417
20MP0009697_abnormal_copulation1.70968768
21MP0006035_abnormal_mitochondrial_morpho1.69856778
22MP0003718_maternal_effect1.65314559
23MP0001929_abnormal_gametogenesis1.65242428
24MP0005387_immune_system_phenotype1.63075109
25MP0001790_abnormal_immune_system1.63075109
26MP0005623_abnormal_meninges_morphology1.59385426
27MP0002822_catalepsy1.58483158
28MP0005167_abnormal_blood-brain_barrier1.54208438
29MP0003698_abnormal_male_reproductive1.53341437
30MP0003183_abnormal_peptide_metabolism1.53012372
31MP0003011_delayed_dark_adaptation1.50173705
32MP0001800_abnormal_humoral_immune1.48320386
33MP0001529_abnormal_vocalization1.46052186
34MP0008875_abnormal_xenobiotic_pharmacok1.44874518
35MP0001919_abnormal_reproductive_system1.41167220
36MP0000372_irregular_coat_pigmentation1.39111723
37MP0004782_abnormal_surfactant_physiolog1.39041138
38MP0003763_abnormal_thymus_physiology1.37922482
39MP0005084_abnormal_gallbladder_morpholo1.36079689
40MP0008007_abnormal_cellular_replicative1.35054147
41MP0002398_abnormal_bone_marrow1.33072392
42MP0005423_abnormal_somatic_nervous1.32618160
43MP0002282_abnormal_trachea_morphology1.31400884
44MP0000465_gastrointestinal_hemorrhage1.31367388
45MP0000689_abnormal_spleen_morphology1.24894272
46MP0002210_abnormal_sex_determination1.24461383
47MP0008932_abnormal_embryonic_tissue1.24328013
48MP0005000_abnormal_immune_tolerance1.22451466
49MP0003221_abnormal_cardiomyocyte_apopto1.22430252
50MP0002234_abnormal_pharynx_morphology1.21338196
51MP0006276_abnormal_autonomic_nervous1.20088028
52MP0002396_abnormal_hematopoietic_system1.17963788
53MP0002102_abnormal_ear_morphology1.17693145
54MP0002736_abnormal_nociception_after1.12436071
55MP0006072_abnormal_retinal_apoptosis1.11004734
56MP0008877_abnormal_DNA_methylation1.10292887
57MP0005451_abnormal_body_composition1.07694888
58MP0002006_tumorigenesis1.06386313
59MP0002722_abnormal_immune_system1.03883544
60MP0001853_heart_inflammation1.02967794
61MP0002161_abnormal_fertility/fecundity1.00029224
62MP0002019_abnormal_tumor_incidence0.99981040
63MP0003880_abnormal_central_pattern0.99161718
64MP0002420_abnormal_adaptive_immunity0.97080907
65MP0002138_abnormal_hepatobiliary_system0.96030363
66MP0001968_abnormal_touch/_nociception0.95264525
67MP0000358_abnormal_cell_content/0.92087885
68MP0005253_abnormal_eye_physiology0.91752564
69MP0000631_abnormal_neuroendocrine_gland0.89934419
70MP0001145_abnormal_male_reproductive0.89903241
71MP0000604_amyloidosis0.89727973
72MP0005389_reproductive_system_phenotype0.89298904
73MP0003656_abnormal_erythrocyte_physiolo0.89201728
74MP0000716_abnormal_immune_system0.87820011
75MP0002735_abnormal_chemical_nociception0.87569272
76MP0002723_abnormal_immune_serum0.87458891
77MP0001819_abnormal_immune_cell0.85384601
78MP0002452_abnormal_antigen_presenting0.84852122
79MP0002429_abnormal_blood_cell0.83946808
80MP0000653_abnormal_sex_gland0.83623318
81MP0002166_altered_tumor_susceptibility0.83032464
82MP0001730_embryonic_growth_arrest0.82743377
83MP0000013_abnormal_adipose_tissue0.82486895
84MP0009745_abnormal_behavioral_response0.79701157
85MP0002148_abnormal_hypersensitivity_rea0.79364864
86MP0002877_abnormal_melanocyte_morpholog0.77663457
87MP0004924_abnormal_behavior0.77597554
88MP0005386_behavior/neurological_phenoty0.77597554
89MP0002733_abnormal_thermal_nociception0.77579264
90MP0010307_abnormal_tumor_latency0.76390051
91MP0004145_abnormal_muscle_electrophysio0.75558851
92MP0008770_decreased_survivor_rate0.73566642
93MP0005647_abnormal_sex_gland0.73481970
94MP0005636_abnormal_mineral_homeostasis0.73301523
95MP0001881_abnormal_mammary_gland0.71313248
96MP0002272_abnormal_nervous_system0.71261062
97MP0001501_abnormal_sleep_pattern0.68977594
98MP0005187_abnormal_penis_morphology0.68191042
99MP0000703_abnormal_thymus_morphology0.68138518
100MP0002693_abnormal_pancreas_physiology0.67992681

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)4.24737745
2Aplastic anemia (HP:0001915)4.12730772
3IgM deficiency (HP:0002850)4.10775567
4Recurrent sinusitis (HP:0011108)4.10772075
5Lipid accumulation in hepatocytes (HP:0006561)4.04523325
6Increased hepatocellular lipid droplets (HP:0006565)3.89804281
7IgA deficiency (HP:0002720)3.60679207
8Agammaglobulinemia (HP:0004432)3.39727461
9Microvesicular hepatic steatosis (HP:0001414)3.38220426
10Recurrent bronchitis (HP:0002837)3.31692978
11IgG deficiency (HP:0004315)3.22727413
12Abnormal gallbladder physiology (HP:0012438)3.06204924
13Cholecystitis (HP:0001082)3.06204924
14Shoulder girdle muscle weakness (HP:0003547)2.93748575
15Lymphopenia (HP:0001888)2.92884804
16Cerebellar dysplasia (HP:0007033)2.72934780
17Abnormality of cells of the lymphoid lineage (HP:0012140)2.71566215
18Chronic diarrhea (HP:0002028)2.71524278
19Abnormality of T cell physiology (HP:0011840)2.68058593
20Autoimmune hemolytic anemia (HP:0001890)2.67250185
21Attenuation of retinal blood vessels (HP:0007843)2.65693207
22Pelvic girdle muscle weakness (HP:0003749)2.62416250
23Renal Fanconi syndrome (HP:0001994)2.62081144
24Atonic seizures (HP:0010819)2.59867344
25Erythema (HP:0010783)2.53388736
26Abnormality of the prostate (HP:0008775)2.50642370
27Increased intramyocellular lipid droplets (HP:0012240)2.50398598
28Methylmalonic acidemia (HP:0002912)2.49851342
29Generalized aminoaciduria (HP:0002909)2.48912869
30Renal cortical cysts (HP:0000803)2.48169339
31Acute hepatic failure (HP:0006554)2.42747735
32Menstrual irregularities (HP:0000858)2.42100809
33Glucose intolerance (HP:0000833)2.40850864
34Squamous cell carcinoma (HP:0002860)2.38424488
35Type II lissencephaly (HP:0007260)2.33751289
36Lissencephaly (HP:0001339)2.32694507
37Increased muscle lipid content (HP:0009058)2.31668152
38Increased CSF lactate (HP:0002490)2.30130046
39Abnormality of the hip-girdle musculature (HP:0001445)2.29927294
40Abnormality of the musculature of the pelvis (HP:0001469)2.29927294
41Mitochondrial inheritance (HP:0001427)2.26380638
42Abnormality of the anterior horn cell (HP:0006802)2.24684383
43Degeneration of anterior horn cells (HP:0002398)2.24684383
44Meningitis (HP:0001287)2.23802735
45Onycholysis (HP:0001806)2.21289073
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20131496
47Increased serum lactate (HP:0002151)2.19120799
48Hepatic necrosis (HP:0002605)2.16400419
49Hypoplasia of the pons (HP:0012110)2.16341826
50Birth length less than 3rd percentile (HP:0003561)2.15279018
51Unilateral renal agenesis (HP:0000122)2.15108946
52Cone-rod dystrophy (HP:0000548)2.07601555
53B lymphocytopenia (HP:0010976)2.06892484
543-Methylglutaconic aciduria (HP:0003535)2.05084079
55Dry hair (HP:0011359)2.04902040
56Abnormality of the pons (HP:0007361)2.03308348
57Abnormal mitochondria in muscle tissue (HP:0008316)2.01277543
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.01095700
59Myelodysplasia (HP:0002863)2.00039458
60Focal motor seizures (HP:0011153)1.96927884
61Prostate neoplasm (HP:0100787)1.96148602
62Abnormality of T cells (HP:0002843)1.95268299
63Acute encephalopathy (HP:0006846)1.93935536
64Spinal muscular atrophy (HP:0007269)1.93355193
65Dicarboxylic aciduria (HP:0003215)1.93177107
66Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93177107
67Acute necrotizing encephalopathy (HP:0006965)1.92974487
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91625637
69Constricted visual fields (HP:0001133)1.90810062
70Deep palmar crease (HP:0006191)1.90488216
71Bronchitis (HP:0012387)1.90419441
72Lymphoma (HP:0002665)1.89617742
73Hepatocellular necrosis (HP:0001404)1.87095429
74Recurrent pneumonia (HP:0006532)1.85625705
75Tubulointerstitial nephritis (HP:0001970)1.84498550
76Abnormality of B cell number (HP:0010975)1.84271350
77Progressive sensorineural hearing impairment (HP:0000408)1.83033860
78Lactic acidosis (HP:0003128)1.82636987
79Cerebral edema (HP:0002181)1.81879961
80Abnormality of the preputium (HP:0100587)1.80291794
81Pancytopenia (HP:0001876)1.80142091
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79146381
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79146381
84Encephalitis (HP:0002383)1.77575331
85Pendular nystagmus (HP:0012043)1.77328759
86Progressive microcephaly (HP:0000253)1.76658312
87Hypoalbuminemia (HP:0003073)1.76538003
88Abnormal albumin level (HP:0012116)1.76538003
89Panhypogammaglobulinemia (HP:0003139)1.76123271
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75240674
91Vasculitis (HP:0002633)1.74945464
92Leukopenia (HP:0001882)1.73703177
93Absence seizures (HP:0002121)1.73549335
94Dyschromatopsia (HP:0007641)1.72270205
95Recurrent viral infections (HP:0004429)1.71766584
96Emphysema (HP:0002097)1.68640359
97Methylmalonic aciduria (HP:0012120)1.68051012
98Meckel diverticulum (HP:0002245)1.67419529
99Rimmed vacuoles (HP:0003805)1.66401471
100Oral leukoplakia (HP:0002745)1.65678441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.71416739
2VRK15.16769218
3TLK14.98915724
4MAP2K74.49481888
5MAP3K43.63910649
6BCKDK3.00079397
7TSSK62.70237115
8TESK22.41137521
9CDC72.32149137
10RPS6KA52.28035993
11PBK2.14070141
12AURKA2.01485834
13PLK42.00808427
14DAPK31.98450693
15SRPK11.97782019
16BUB11.93238555
17INSRR1.77248581
18SCYL21.69953545
19EIF2AK31.59527777
20VRK21.46260979
21TAF11.43565215
22KDR1.36169547
23PLK21.29005030
24CSNK1A1L1.18080012
25CDK121.09343412
26CSNK1G31.08446318
27MAP2K41.06200564
28STK161.05464251
29CCNB11.05100694
30AURKB1.04993682
31TNK20.96334450
32PLK30.96056430
33ATR0.95146579
34SMG10.95130303
35CSNK1G20.87551682
36TAOK30.87127020
37TESK10.86068433
38AKT30.84021104
39CHEK20.82415742
40SYK0.81373752
41PLK10.79491335
42CSNK1G10.76466807
43NUAK10.72880996
44ALK0.70911698
45MAPKAPK30.68262421
46TEC0.67152437
47ITK0.65672885
48BTK0.65644459
49PKN10.64992059
50NEK10.63273056
51CHEK10.61163344
52SIK20.58037447
53EIF2AK10.56130056
54CSNK2A20.53676616
55TTK0.52570525
56ERBB30.52409343
57STK40.51872478
58DAPK10.51727587
59CDK70.51203925
60EPHA40.50877807
61PRKCQ0.50173212
62ATM0.49592603
63TRPM70.48949834
64RIPK40.48425927
65IRAK40.47607617
66AKT20.46972556
67NEK20.44764299
68MARK10.44385966
69CDK20.43022756
70BRD40.41897401
71CDK10.40113208
72WNK30.39645974
73EIF2AK20.39304325
74CSNK2A10.38069009
75MKNK20.34383080
76MAPKAPK50.33309559
77FER0.33255774
78CSF1R0.32983144
79BRSK20.32032845
80CSNK1E0.31213293
81MAP4K10.30964475
82RPS6KB20.30309421
83DYRK30.30298969
84PRKCB0.30198217
85PRKDC0.30013773
86LYN0.29586001
87CSNK1A10.26035588
88PRKAA10.22612864
89CDK80.22278492
90MAPK110.21301078
91WNK40.21275708
92MAP4K20.20332322
93PIK3CG0.20311196
94CDK40.18995164
95MAPK90.18817034
96PRKCA0.18781627
97CLK10.18702197
98PAK10.18621274
99GSK3B0.18426532
100BRAF0.18384798

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053228.49383504
2Alcoholism_Homo sapiens_hsa050345.62223714
3Allograft rejection_Homo sapiens_hsa053302.86143832
4Autoimmune thyroid disease_Homo sapiens_hsa053202.73187117
5Type I diabetes mellitus_Homo sapiens_hsa049402.60644686
6Graft-versus-host disease_Homo sapiens_hsa053322.48614708
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.47309216
8Viral carcinogenesis_Homo sapiens_hsa052032.42760066
9Primary immunodeficiency_Homo sapiens_hsa053402.41331418
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26714753
11Asthma_Homo sapiens_hsa053102.23653541
12DNA replication_Homo sapiens_hsa030302.11605227
13Proteasome_Homo sapiens_hsa030502.01314862
14Spliceosome_Homo sapiens_hsa030401.97307603
15Antigen processing and presentation_Homo sapiens_hsa046121.91174444
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.77227446
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76019319
18Mismatch repair_Homo sapiens_hsa034301.69434193
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63735996
20Viral myocarditis_Homo sapiens_hsa054161.56727101
21Homologous recombination_Homo sapiens_hsa034401.50811296
22RNA transport_Homo sapiens_hsa030131.48133230
23Base excision repair_Homo sapiens_hsa034101.39821668
24One carbon pool by folate_Homo sapiens_hsa006701.36666854
25Nucleotide excision repair_Homo sapiens_hsa034201.27842641
26Selenocompound metabolism_Homo sapiens_hsa004501.24587920
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17026917
28Non-homologous end-joining_Homo sapiens_hsa034501.14182440
29Fanconi anemia pathway_Homo sapiens_hsa034601.07837314
30Oxidative phosphorylation_Homo sapiens_hsa001901.04599057
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99307034
32Basal transcription factors_Homo sapiens_hsa030220.95874601
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94904080
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93937914
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88389863
36Sulfur metabolism_Homo sapiens_hsa009200.86825493
37Sulfur relay system_Homo sapiens_hsa041220.86399969
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86286476
39RNA polymerase_Homo sapiens_hsa030200.85740244
40Pyrimidine metabolism_Homo sapiens_hsa002400.82801627
41Fatty acid biosynthesis_Homo sapiens_hsa000610.82644783
42Hematopoietic cell lineage_Homo sapiens_hsa046400.75858987
43Parkinsons disease_Homo sapiens_hsa050120.75320520
44Propanoate metabolism_Homo sapiens_hsa006400.75315283
45Biosynthesis of amino acids_Homo sapiens_hsa012300.74012601
46Rheumatoid arthritis_Homo sapiens_hsa053230.71936057
47Epstein-Barr virus infection_Homo sapiens_hsa051690.68421539
48Carbon metabolism_Homo sapiens_hsa012000.67903148
49Herpes simplex infection_Homo sapiens_hsa051680.66279211
50Phototransduction_Homo sapiens_hsa047440.60541865
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59640272
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57958285
53RNA degradation_Homo sapiens_hsa030180.57619612
54Purine metabolism_Homo sapiens_hsa002300.55311165
55Cell cycle_Homo sapiens_hsa041100.54405979
56Nicotine addiction_Homo sapiens_hsa050330.53831951
57mRNA surveillance pathway_Homo sapiens_hsa030150.50791087
58Huntingtons disease_Homo sapiens_hsa050160.49904710
59Protein export_Homo sapiens_hsa030600.47511039
60Butanoate metabolism_Homo sapiens_hsa006500.45452358
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44298551
62Oocyte meiosis_Homo sapiens_hsa041140.42462045
63Alzheimers disease_Homo sapiens_hsa050100.41973928
64Fatty acid metabolism_Homo sapiens_hsa012120.38500827
65Olfactory transduction_Homo sapiens_hsa047400.35821047
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35292864
67Pentose phosphate pathway_Homo sapiens_hsa000300.33463732
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30330771
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29002067
70Leishmaniasis_Homo sapiens_hsa051400.27642775
71Staphylococcus aureus infection_Homo sapiens_hsa051500.27238160
72Cardiac muscle contraction_Homo sapiens_hsa042600.27074448
73Peroxisome_Homo sapiens_hsa041460.25277805
74HTLV-I infection_Homo sapiens_hsa051660.23887581
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.23463586
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22991826
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22220097
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22201077
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21484641
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20607226
81B cell receptor signaling pathway_Homo sapiens_hsa046620.20234936
82Phagosome_Homo sapiens_hsa041450.19759159
83Synaptic vesicle cycle_Homo sapiens_hsa047210.18101252
84Phenylalanine metabolism_Homo sapiens_hsa003600.18083415
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.17265498
86p53 signaling pathway_Homo sapiens_hsa041150.17035796
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17019238
88Tryptophan metabolism_Homo sapiens_hsa003800.16708721
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16578970
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15975708
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.15756127
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15568615
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14240821
94Pyruvate metabolism_Homo sapiens_hsa006200.13925754
95Metabolic pathways_Homo sapiens_hsa011000.11696174
96Measles_Homo sapiens_hsa051620.10930244
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10912134
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10576057
99Fatty acid elongation_Homo sapiens_hsa000620.09969828
100Apoptosis_Homo sapiens_hsa042100.09614654

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