ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.19182787
2	positive regulation of action potential (GO:0045760)	4.74816410
3	protein neddylation (GO:0045116)	4.43766243
4	DNA double-strand break processing (GO:0000729)	4.35234496
5	protein insertion into membrane (GO:0051205)	4.03236102
6	nucleobase catabolic process (GO:0046113)	3.93428760
7	kinetochore assembly (GO:0051382)	3.91623493
8	erythrocyte maturation (GO:0043249)	3.77124061
9	single strand break repair (GO:0000012)	3.71422493
10	resolution of meiotic recombination intermediates (GO:0000712)	3.67096767
11	protoporphyrinogen IX metabolic process (GO:0046501)	3.65849569
12	somite development (GO:0061053)	3.63698948
13	kinetochore organization (GO:0051383)	3.63489860
14	positive regulation of mitochondrial fission (GO:0090141)	3.56666873
15	spinal cord association neuron differentiation (GO:0021527)	3.53004989
16	DNA replication checkpoint (GO:0000076)	3.48888246
17	chaperone-mediated protein transport (GO:0072321)	3.33748086
18	porphyrin-containing compound biosynthetic process (GO:0006779)	3.32928722
19	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.31456618
20	DNA integration (GO:0015074)	3.31363723
21	presynaptic membrane organization (GO:0097090)	3.28438578
22	protein-cofactor linkage (GO:0018065)	3.23985722
23	double-strand break repair via nonhomologous end joining (GO:0006303)	3.19054772
24	non-recombinational repair (GO:0000726)	3.19054772
25	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.15408962
26	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.14735676
27	regulation of action potential (GO:0098900)	3.13956820
28	cholesterol biosynthetic process (GO:0006695)	3.11432723
29	tetrapyrrole biosynthetic process (GO:0033014)	3.10157060
30	replication fork processing (GO:0031297)	3.10052774
31	cornea development in camera-type eye (GO:0061303)	3.08558622
32	fibroblast migration (GO:0010761)	3.02791716
33	regulation of mitotic spindle checkpoint (GO:1903504)	3.02165590
34	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.02165590
35	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.98329379
36	porphyrin-containing compound metabolic process (GO:0006778)	2.97757265
37	presynaptic membrane assembly (GO:0097105)	2.93787727
38	negative regulation of heart rate (GO:0010459)	2.91729450
39	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.90334117
40	response to nitrosative stress (GO:0051409)	2.87490112
41	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86795027
42	protein complex biogenesis (GO:0070271)	2.84950337
43	negative regulation of axon guidance (GO:1902668)	2.81726139
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81493585
45	cerebellar Purkinje cell differentiation (GO:0021702)	2.80566886
46	tachykinin receptor signaling pathway (GO:0007217)	2.80460458
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.79250267
48	positive regulation of amino acid transport (GO:0051957)	2.78785598
49	establishment of mitochondrion localization (GO:0051654)	2.76952835
50	regulation of centriole replication (GO:0046599)	2.76774525
51	chromatin remodeling at centromere (GO:0031055)	2.76061508
52	protein localization to kinetochore (GO:0034501)	2.76054601
53	metaphase plate congression (GO:0051310)	2.74918497
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.74597071
55	postsynaptic membrane organization (GO:0001941)	2.72448456
56	positive regulation of gastrulation (GO:2000543)	2.66042175
57	protein polyglutamylation (GO:0018095)	2.66012800
58	cell proliferation in forebrain (GO:0021846)	2.64797520
59	sterol biosynthetic process (GO:0016126)	2.64681035
60	establishment of integrated proviral latency (GO:0075713)	2.64414180
61	heme transport (GO:0015886)	2.63338763
62	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.62521331
63	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61859927
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61859927
65	NADH dehydrogenase complex assembly (GO:0010257)	2.61859927
66	arginine metabolic process (GO:0006525)	2.61458551
67	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.61200911
68	positive regulation of microtubule polymerization (GO:0031116)	2.60582122
69	genetic imprinting (GO:0071514)	2.57098585
70	neurotransmitter-gated ion channel clustering (GO:0072578)	2.56332061
71	protein localization to chromosome, centromeric region (GO:0071459)	2.56069481
72	positive regulation of cell size (GO:0045793)	2.55644492
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55391086
74	termination of RNA polymerase III transcription (GO:0006386)	2.55391086
75	regulation of DNA endoreduplication (GO:0032875)	2.55067638
76	female gonad development (GO:0008585)	2.52912128
77	DNA ligation (GO:0006266)	2.52130726
78	regulation of helicase activity (GO:0051095)	2.50377210
79	neuronal ion channel clustering (GO:0045161)	2.49719872
80	regulation of appetite (GO:0032098)	2.49681207
81	CENP-A containing nucleosome assembly (GO:0034080)	2.49611380
82	maturation of 5.8S rRNA (GO:0000460)	2.48776055
83	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.48773638
84	heme biosynthetic process (GO:0006783)	2.47871931
85	arginine catabolic process (GO:0006527)	2.47584017
86	vocalization behavior (GO:0071625)	2.47475622
87	histone exchange (GO:0043486)	2.46317151
88	respiratory chain complex IV assembly (GO:0008535)	2.45995856
89	negative regulation of DNA recombination (GO:0045910)	2.43971129
90	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.41778225
91	peptidyl-cysteine modification (GO:0018198)	2.41509069
92	DNA methylation involved in gamete generation (GO:0043046)	2.40871727
93	protein localization to synapse (GO:0035418)	2.39995336
94	regulation of cilium movement (GO:0003352)	2.37880510
95	synapsis (GO:0007129)	2.36141010
96	DNA replication-independent nucleosome organization (GO:0034724)	2.36075600
97	DNA replication-independent nucleosome assembly (GO:0006336)	2.36075600
98	histone mRNA metabolic process (GO:0008334)	2.35739900
99	adult walking behavior (GO:0007628)	2.35726942
100	DNA topological change (GO:0006265)	2.34654355

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.72031100
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.66156544
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.60385778
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.30267016
5	E2F7_22180533_ChIP-Seq_HELA_Human	3.20418184
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.16656726
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03858629
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.03735286
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.83546250
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.76242271
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69090591
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61537557
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.55766074
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.46063209
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.44776630
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.32481814
17	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.92732119
18	EWS_26573619_Chip-Seq_HEK293_Human	1.90781404
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.87469658
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.84937183
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81800891
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.80508324
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.77578390
24	FUS_26573619_Chip-Seq_HEK293_Human	1.73822568
25	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.72172982
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.70744878
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68703181
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.61808388
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61360260
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58927961
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.56679335
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.55209540
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52959710
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52805320
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.50090382
36	P300_19829295_ChIP-Seq_ESCs_Human	1.45697039
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45443406
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.45075696
39	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.44133969
40	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.43479171
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42934345
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.42681586
43	VDR_22108803_ChIP-Seq_LS180_Human	1.40849277
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40737491
45	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.36311740
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35444052
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34618151
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34324446
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.34086034
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33817721
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32240841
52	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.30919941
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27453436
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26582373
55	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.25543989
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25314421
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24748731
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24045377
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.23700314
60	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.21233138
61	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.18566899
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13823964
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13662423
64	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.12422011
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11527088
66	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.08820048
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07513176
68	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.06935070
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.06634416
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05540739
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03727287
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02591118
73	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02434365
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02334580
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.00998663
76	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00783236
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98920286
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98072721
79	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97567722
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95617328
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94400351
82	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93114492
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93114492
84	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.91642645
85	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.90718809
86	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.89539079
87	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89096389
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88529310
89	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.88515113
90	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88503459
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87887901
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87661155
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.87607713
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87273367
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87060110
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.85579693
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.85579693
98	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.85494073
99	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85239851
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.85204585

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	5.06847018
2	MP0004147_increased_porphyrin_level	4.45977949
3	MP0003122_maternal_imprinting	4.09065494
4	MP0001529_abnormal_vocalization	3.77606912
5	MP0003121_genomic_imprinting	3.59749187
6	MP0008877_abnormal_DNA_methylation	3.59660135
7	MP0003123_paternal_imprinting	3.57461817
8	MP0003011_delayed_dark_adaptation	3.40968951
9	MP0003880_abnormal_central_pattern	3.00020683
10	MP0005083_abnormal_biliary_tract	2.95179292
11	MP0006276_abnormal_autonomic_nervous	2.52143991
12	MP0008995_early_reproductive_senescence	2.40137103
13	MP0002736_abnormal_nociception_after	2.31510192
14	MP0003890_abnormal_embryonic-extraembry	2.18050527
15	MP0005394_taste/olfaction_phenotype	2.17721559
16	MP0005499_abnormal_olfactory_system	2.17721559
17	MP0008058_abnormal_DNA_repair	2.13262857
18	MP0008789_abnormal_olfactory_epithelium	2.07469450
19	MP0003656_abnormal_erythrocyte_physiolo	1.87934410
20	MP0001986_abnormal_taste_sensitivity	1.85581907
21	MP0001188_hyperpigmentation	1.84522646
22	MP0010094_abnormal_chromosome_stability	1.82250749
23	MP0006292_abnormal_olfactory_placode	1.81278428
24	MP0003111_abnormal_nucleus_morphology	1.76385645
25	MP0001968_abnormal_touch/_nociception	1.68138169
26	MP0004859_abnormal_synaptic_plasticity	1.64812736
27	MP0005423_abnormal_somatic_nervous	1.55268690
28	MP0002653_abnormal_ependyma_morphology	1.50496233
29	MP0005084_abnormal_gallbladder_morpholo	1.50012737
30	MP0000778_abnormal_nervous_system	1.40924619
31	MP0003693_abnormal_embryo_hatching	1.38783150
32	MP0002557_abnormal_social/conspecific_i	1.31176644
33	MP0003635_abnormal_synaptic_transmissio	1.22439948
34	MP0002751_abnormal_autonomic_nervous	1.21980074
35	MP0002734_abnormal_mechanical_nocicepti	1.21693207
36	MP0008872_abnormal_physiological_respon	1.19447163
37	MP0005551_abnormal_eye_electrophysiolog	1.17238932
38	MP0000631_abnormal_neuroendocrine_gland	1.12157690
39	MP0005253_abnormal_eye_physiology	1.10848767
40	MP0003941_abnormal_skin_development	1.10205365
41	MP0003786_premature_aging	1.09615370
42	MP0002063_abnormal_learning/memory/cond	1.08933867
43	MP0008007_abnormal_cellular_replicative	1.06830710
44	MP0002572_abnormal_emotion/affect_behav	1.04615311
45	MP0009745_abnormal_behavioral_response	1.04511072
46	MP0003718_maternal_effect	1.04510890
47	MP0002735_abnormal_chemical_nociception	1.04265822
48	MP0004270_analgesia	1.03141852
49	MP0003119_abnormal_digestive_system	1.02908381
50	MP0002210_abnormal_sex_determination	1.01242532
51	MP0002184_abnormal_innervation	1.00801013
52	MP0004811_abnormal_neuron_physiology	0.97816241
53	MP0004957_abnormal_blastocyst_morpholog	0.97468169
54	MP0002102_abnormal_ear_morphology	0.95162946
55	MP0003077_abnormal_cell_cycle	0.93987220
56	MP0002152_abnormal_brain_morphology	0.93018843
57	MP0002067_abnormal_sensory_capabilities	0.90687325
58	MP0003861_abnormal_nervous_system	0.90074037
59	MP0000372_irregular_coat_pigmentation	0.89312679
60	MP0002272_abnormal_nervous_system	0.87749726
61	MP0003942_abnormal_urinary_system	0.86128934
62	MP0002882_abnormal_neuron_morphology	0.85843266
63	MP0003186_abnormal_redox_activity	0.85492182
64	MP0005636_abnormal_mineral_homeostasis	0.85103606
65	MP0000647_abnormal_sebaceous_gland	0.84543453
66	MP0000955_abnormal_spinal_cord	0.83499200
67	MP0005645_abnormal_hypothalamus_physiol	0.82421854
68	MP0003385_abnormal_body_wall	0.82057689
69	MP0001145_abnormal_male_reproductive	0.81974914
70	MP0004142_abnormal_muscle_tone	0.81892775
71	MP0001970_abnormal_pain_threshold	0.81818820
72	MP0001984_abnormal_olfaction	0.81372924
73	MP0006072_abnormal_retinal_apoptosis	0.80951576
74	MP0005386_behavior/neurological_phenoty	0.80488053
75	MP0004924_abnormal_behavior	0.80488053
76	MP0005248_abnormal_Harderian_gland	0.80075439
77	MP0001929_abnormal_gametogenesis	0.79930165
78	MP0000653_abnormal_sex_gland	0.79870120
79	MP0002752_abnormal_somatic_nervous	0.79158907
80	MP0005187_abnormal_penis_morphology	0.78424058
81	MP0001486_abnormal_startle_reflex	0.77337372
82	MP0002733_abnormal_thermal_nociception	0.77082040
83	MP0003698_abnormal_male_reproductive	0.76798465
84	MP0001119_abnormal_female_reproductive	0.76664282
85	MP0003315_abnormal_perineum_morphology	0.74393630
86	MP0001919_abnormal_reproductive_system	0.72552773
87	MP0003937_abnormal_limbs/digits/tail_de	0.71410215
88	MP0002160_abnormal_reproductive_system	0.70697215
89	MP0008932_abnormal_embryonic_tissue	0.69744407
90	MP0004019_abnormal_vitamin_homeostasis	0.64756714
91	MP0005195_abnormal_posterior_eye	0.63774086
92	MP0001293_anophthalmia	0.61243947
93	MP0000639_abnormal_adrenal_gland	0.61016289
94	MP0005389_reproductive_system_phenotype	0.60140195
95	MP0001286_abnormal_eye_development	0.59956412
96	MP0004133_heterotaxia	0.58987544
97	MP0009697_abnormal_copulation	0.56572107
98	MP0004145_abnormal_muscle_electrophysio	0.56172096
99	MP0005380_embryogenesis_phenotype	0.56162706
100	MP0001672_abnormal_embryogenesis/_devel	0.56162706

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatoblastoma (HP:0002884)	4.94781475
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.14477029
3	Abnormality of the labia minora (HP:0012880)	4.11748918
4	Poikilocytosis (HP:0004447)	3.99400482
5	Neoplasm of the adrenal cortex (HP:0100641)	3.80147041
6	Agitation (HP:0000713)	3.69934309
7	Myokymia (HP:0002411)	3.67247726
8	Hypochromic microcytic anemia (HP:0004840)	3.35773985
9	Septo-optic dysplasia (HP:0100842)	3.08682343
10	Colon cancer (HP:0003003)	2.95865205
11	Polyphagia (HP:0002591)	2.79246002
12	Cortical dysplasia (HP:0002539)	2.71804324
13	Impaired vibration sensation in the lower limbs (HP:0002166)	2.68414820
14	Sensory axonal neuropathy (HP:0003390)	2.63778502
15	Abnormal lung lobation (HP:0002101)	2.63494180
16	Abnormal hair whorl (HP:0010721)	2.58808392
17	Progressive inability to walk (HP:0002505)	2.56757427
18	Neoplasm of the adrenal gland (HP:0100631)	2.53819850
19	Hyperglycinemia (HP:0002154)	2.51679262
20	Poor suck (HP:0002033)	2.51013379
21	Restlessness (HP:0000711)	2.48372628
22	Microvesicular hepatic steatosis (HP:0001414)	2.47781360
23	Drooling (HP:0002307)	2.46737573
24	Acanthocytosis (HP:0001927)	2.45091987
25	Growth hormone deficiency (HP:0000824)	2.42669402
26	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.38280183
27	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.38280183
28	Autoamputation (HP:0001218)	2.33778584
29	Abnormality of chromosome stability (HP:0003220)	2.28490674
30	Excessive salivation (HP:0003781)	2.23365824
31	Limb dystonia (HP:0002451)	2.22106030
32	Gonadotropin excess (HP:0000837)	2.18570654
33	Paralysis (HP:0003470)	2.18277011
34	Acute encephalopathy (HP:0006846)	2.18131170
35	Meckel diverticulum (HP:0002245)	2.18079620
36	Reticulocytosis (HP:0001923)	2.17683049
37	Diastasis recti (HP:0001540)	2.16835057
38	Abnormality of the corticospinal tract (HP:0002492)	2.16759604
39	Inability to walk (HP:0002540)	2.16755852
40	Nephronophthisis (HP:0000090)	2.15710604
41	Small hand (HP:0200055)	2.09227521
42	Abnormal social behavior (HP:0012433)	2.06886593
43	Impaired social interactions (HP:0000735)	2.06886593
44	Morphological abnormality of the pyramidal tract (HP:0002062)	2.05277858
45	Thyroid-stimulating hormone excess (HP:0002925)	2.04829016
46	Hypothermia (HP:0002045)	2.03237802
47	Osteomalacia (HP:0002749)	2.03022942
48	Volvulus (HP:0002580)	2.00834518
49	Supernumerary spleens (HP:0009799)	2.00567262
50	Hip dysplasia (HP:0001385)	2.00240291
51	Abnormality of the ileum (HP:0001549)	1.98008609
52	Medial flaring of the eyebrow (HP:0010747)	1.96829969
53	Hyperbilirubinemia (HP:0002904)	1.93727909
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93542844
55	Lissencephaly (HP:0001339)	1.93008926
56	Medulloblastoma (HP:0002885)	1.88234481
57	Bifid tongue (HP:0010297)	1.88069366
58	Spontaneous abortion (HP:0005268)	1.87923193
59	Limb hypertonia (HP:0002509)	1.87379657
60	Spastic tetraplegia (HP:0002510)	1.87080493
61	Abolished electroretinogram (ERG) (HP:0000550)	1.85542783
62	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.84803970
63	Truncal obesity (HP:0001956)	1.83575038
64	Facial cleft (HP:0002006)	1.83062636
65	Median cleft lip (HP:0000161)	1.82704205
66	Neoplasm of the oral cavity (HP:0100649)	1.82473249
67	Double outlet right ventricle (HP:0001719)	1.82212780
68	Congenital malformation of the right heart (HP:0011723)	1.82212780
69	Sloping forehead (HP:0000340)	1.82052144
70	Absent septum pellucidum (HP:0001331)	1.79799852
71	Failure to thrive in infancy (HP:0001531)	1.79494038
72	Acute necrotizing encephalopathy (HP:0006965)	1.78532075
73	Bony spicule pigmentary retinopathy (HP:0007737)	1.76762471
74	Abnormality of the preputium (HP:0100587)	1.76173883
75	Poor eye contact (HP:0000817)	1.75411662
76	Severe visual impairment (HP:0001141)	1.75096854
77	Abnormality of reticulocytes (HP:0004312)	1.73104557
78	Abnormal pancreas size (HP:0012094)	1.72468511
79	Broad alveolar ridges (HP:0000187)	1.72022430
80	Molar tooth sign on MRI (HP:0002419)	1.70119868
81	Abnormality of midbrain morphology (HP:0002418)	1.70119868
82	Exotropia (HP:0000577)	1.70061611
83	Nephrogenic diabetes insipidus (HP:0009806)	1.68814143
84	Increased CSF lactate (HP:0002490)	1.68379492
85	Abnormal mitochondria in muscle tissue (HP:0008316)	1.67842184
86	Nephroblastoma (Wilms tumor) (HP:0002667)	1.64285700
87	Duodenal stenosis (HP:0100867)	1.63098014
88	Small intestinal stenosis (HP:0012848)	1.63098014
89	Scrotal hypoplasia (HP:0000046)	1.61834062
90	Impaired vibratory sensation (HP:0002495)	1.61620500
91	Curly hair (HP:0002212)	1.61286758
92	Abnormality of the astrocytes (HP:0100707)	1.60709210
93	Astrocytoma (HP:0009592)	1.60709210
94	Abnormality of the septum pellucidum (HP:0007375)	1.60590124
95	Gait imbalance (HP:0002141)	1.59492127
96	Abnormality of the labia (HP:0000058)	1.58200951
97	Disproportionate short-trunk short stature (HP:0003521)	1.57256508
98	Birth length less than 3rd percentile (HP:0003561)	1.57160589
99	Labial hypoplasia (HP:0000066)	1.56805180
100	Tubulointerstitial nephritis (HP:0001970)	1.56437916

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.98793268
2	MARK1	3.84618517
3	MAP4K2	3.83295863
4	CDC7	3.24721755
5	EIF2AK1	3.20516672
6	TRIM28	2.80960527
7	STK16	2.63999078
8	MAPK13	2.48373565
9	EPHA4	2.29410329
10	NUAK1	2.08403260
11	MKNK2	2.06028814
12	DYRK3	1.95967109
13	DYRK2	1.88458372
14	MAP2K7	1.84030260
15	MKNK1	1.81527427
16	AKT3	1.79128189
17	CSNK1G2	1.74195751
18	ZAK	1.72157473
19	BUB1	1.69925785
20	WNK3	1.68662235
21	CASK	1.66724090
22	TTK	1.58929832
23	SIK3	1.56221089
24	TAF1	1.48553028
25	DYRK1B	1.46496045
26	MAP3K4	1.43900463
27	MST4	1.43728417
28	CSNK1G1	1.43269665
29	PLK3	1.39011179
30	CSNK1G3	1.36258516
31	CSNK1A1L	1.34788798
32	SRPK1	1.24370028
33	PLK1	1.21413585
34	BCR	1.17065599
35	BRSK2	1.16198157
36	PLK2	1.14964721
37	MAP2K4	1.12955056
38	PLK4	1.10552878
39	TSSK6	1.08203369
40	MINK1	1.07541400
41	PINK1	1.02484483
42	ATR	1.01954640
43	CAMK1D	1.01227655
44	WEE1	0.98932973
45	UHMK1	0.90958828
46	DYRK1A	0.90432631
47	PRKCG	0.87640223
48	CAMKK2	0.85773214
49	GRK1	0.78894719
50	CDK14	0.72453021
51	STK11	0.71618414
52	BRSK1	0.69901802
53	PIM2	0.67752668
54	NTRK2	0.67572373
55	PAK3	0.67496760
56	CDK18	0.67081887
57	CHEK2	0.66342421
58	CDK3	0.63950057
59	CAMK1G	0.63745638
60	SGK223	0.62591459
61	SGK494	0.62591459
62	CDK15	0.59910653
63	NTRK3	0.59533164
64	BRAF	0.59436799
65	OXSR1	0.57580227
66	PRKCE	0.57079568
67	ATM	0.53328209
68	CDK11A	0.52407630
69	SGK2	0.52309100
70	PRKDC	0.51770636
71	CSNK1E	0.51301728
72	CAMK4	0.51253418
73	MAP3K12	0.50884916
74	FRK	0.50330315
75	VRK1	0.49783163
76	TNK2	0.48850822
77	CDK5	0.48346536
78	BCKDK	0.48315198
79	CAMK1	0.46292834
80	PRKAA1	0.44248514
81	CHEK1	0.44239305
82	CDK2	0.43704745
83	PBK	0.41747485
84	CDK1	0.41686988
85	MAP3K5	0.41368415
86	VRK2	0.41178413
87	CSNK2A1	0.40766567
88	CSNK1D	0.40056864
89	ERBB3	0.38595559
90	EIF2AK3	0.37797804
91	PRKACA	0.37761519
92	AURKA	0.37684278
93	CDK19	0.35205311
94	ALK	0.33838290
95	MAPKAPK5	0.33680463
96	PRKACB	0.33500085
97	MAP3K11	0.33486762
98	RPS6KA5	0.32820926
99	CSNK1A1	0.32774426
100	GSK3B	0.32469641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.87857737
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.37581985
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.71610566
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.63242892
5	Proteasome_Homo sapiens_hsa03050	2.52536696
6	RNA polymerase_Homo sapiens_hsa03020	2.46087592
7	Nicotine addiction_Homo sapiens_hsa05033	2.28283864
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.24915598
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.09075338
10	Parkinsons disease_Homo sapiens_hsa05012	2.03586726
11	Homologous recombination_Homo sapiens_hsa03440	2.01335323
12	Basal transcription factors_Homo sapiens_hsa03022	1.96409979
13	Butanoate metabolism_Homo sapiens_hsa00650	1.82716449
14	Mismatch repair_Homo sapiens_hsa03430	1.74248838
15	Huntingtons disease_Homo sapiens_hsa05016	1.73317835
16	Morphine addiction_Homo sapiens_hsa05032	1.72801304
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67296731
18	RNA degradation_Homo sapiens_hsa03018	1.63222251
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.59047873
20	Protein export_Homo sapiens_hsa03060	1.52940069
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48577225
22	GABAergic synapse_Homo sapiens_hsa04727	1.47883577
23	Phototransduction_Homo sapiens_hsa04744	1.45806781
24	mRNA surveillance pathway_Homo sapiens_hsa03015	1.43894160
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43887845
26	Propanoate metabolism_Homo sapiens_hsa00640	1.43550594
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.39820417
28	RNA transport_Homo sapiens_hsa03013	1.37926542
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36428461
30	DNA replication_Homo sapiens_hsa03030	1.36191159
31	Spliceosome_Homo sapiens_hsa03040	1.28059138
32	Cell cycle_Homo sapiens_hsa04110	1.25975537
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.25024966
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23539944
35	Caffeine metabolism_Homo sapiens_hsa00232	1.23179871
36	Alzheimers disease_Homo sapiens_hsa05010	1.21188659
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19664382
38	Peroxisome_Homo sapiens_hsa04146	1.17710122
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.17697105
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16065983
41	Nitrogen metabolism_Homo sapiens_hsa00910	1.05870662
42	Purine metabolism_Homo sapiens_hsa00230	1.04302094
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00782935
44	Oocyte meiosis_Homo sapiens_hsa04114	1.00187323
45	Base excision repair_Homo sapiens_hsa03410	0.99041224
46	Regulation of autophagy_Homo sapiens_hsa04140	0.96821063
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96471775
48	Dopaminergic synapse_Homo sapiens_hsa04728	0.95391579
49	Taste transduction_Homo sapiens_hsa04742	0.95372570
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95284547
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94195244
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.93737014
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91697006
54	Circadian entrainment_Homo sapiens_hsa04713	0.90037050
55	Olfactory transduction_Homo sapiens_hsa04740	0.87597726
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.80421094
57	One carbon pool by folate_Homo sapiens_hsa00670	0.80388065
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78318170
59	Fatty acid elongation_Homo sapiens_hsa00062	0.78248742
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76306844
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75838154
62	Serotonergic synapse_Homo sapiens_hsa04726	0.75436004
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73547159
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.72586575
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.71428469
66	Arginine biosynthesis_Homo sapiens_hsa00220	0.68250887
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67241718
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.67020053
69	Metabolic pathways_Homo sapiens_hsa01100	0.66115787
70	Carbon metabolism_Homo sapiens_hsa01200	0.64100607
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62915765
72	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.62667668
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.60767232
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60299017
75	Amphetamine addiction_Homo sapiens_hsa05031	0.57763940
76	Retinol metabolism_Homo sapiens_hsa00830	0.57686888
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56801865
78	Sulfur relay system_Homo sapiens_hsa04122	0.55922676
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.54791354
80	Fatty acid degradation_Homo sapiens_hsa00071	0.53729508
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.52043298
82	Alcoholism_Homo sapiens_hsa05034	0.48560386
83	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48410174
84	Insulin secretion_Homo sapiens_hsa04911	0.47328519
85	Long-term depression_Homo sapiens_hsa04730	0.45742377
86	Folate biosynthesis_Homo sapiens_hsa00790	0.42783509
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41811034
88	Glutathione metabolism_Homo sapiens_hsa00480	0.41606666
89	Axon guidance_Homo sapiens_hsa04360	0.39659582
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.39640873
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38307663
92	Gap junction_Homo sapiens_hsa04540	0.38061439
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38009822
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.37661814
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37144729
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35560638
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35063328
98	Ribosome_Homo sapiens_hsa03010	0.34735020
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.34222695
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33478697

EIF4HP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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