EIF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.60474431
2mitotic metaphase plate congression (GO:0007080)4.92243201
3purine nucleobase biosynthetic process (GO:0009113)4.81736936
4regulation of spindle organization (GO:0090224)4.71733906
5nuclear pore organization (GO:0006999)4.68761721
6nuclear pore complex assembly (GO:0051292)4.63683469
7regulation of translational termination (GO:0006449)4.57138401
8sister chromatid cohesion (GO:0007062)4.47389597
9nucleobase biosynthetic process (GO:0046112)4.46832895
10folic acid metabolic process (GO:0046655)4.35539561
11mitotic sister chromatid cohesion (GO:0007064)4.27644049
12mitotic nuclear envelope disassembly (GO:0007077)4.26936327
13regulation of DNA endoreduplication (GO:0032875)4.23780795
14male meiosis I (GO:0007141)4.17962953
15regulation of transcription from RNA polymerase I promoter (GO:0006356)4.09282345
16metaphase plate congression (GO:0051310)4.08253061
17regulation of RNA export from nucleus (GO:0046831)4.07762207
18nuclear envelope disassembly (GO:0051081)4.07446902
19membrane disassembly (GO:0030397)4.07446902
20DNA synthesis involved in DNA repair (GO:0000731)4.07246516
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.06577802
22synapsis (GO:0007129)4.04218519
23monoubiquitinated protein deubiquitination (GO:0035520)3.98749254
24positive regulation of chromosome segregation (GO:0051984)3.94710545
25protein localization to kinetochore (GO:0034501)3.94364315
26meiotic chromosome segregation (GO:0045132)3.92070185
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.89234324
28establishment of integrated proviral latency (GO:0075713)3.86472966
29chromosome organization involved in meiosis (GO:0070192)3.83507395
30regulation of mitotic spindle organization (GO:0060236)3.78992960
31piRNA metabolic process (GO:0034587)3.73273408
32ribosome biogenesis (GO:0042254)3.71627735
33protein localization to chromosome, centromeric region (GO:0071459)3.63441397
34regulation of histone H3-K9 methylation (GO:0051570)3.62159376
35DNA replication checkpoint (GO:0000076)3.56621135
36meiotic nuclear division (GO:0007126)3.54945716
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51759163
38folic acid-containing compound biosynthetic process (GO:0009396)3.50804258
39formation of translation preinitiation complex (GO:0001731)3.49263341
40pore complex assembly (GO:0046931)3.48368977
41nuclear envelope organization (GO:0006998)3.47265123
42histone-serine phosphorylation (GO:0035404)3.47021166
43intestinal epithelial cell development (GO:0060576)3.46045643
44meiosis I (GO:0007127)3.45593748
45proteasome assembly (GO:0043248)3.45010265
46DNA strand elongation involved in DNA replication (GO:0006271)3.41475199
47regulation of chromosome segregation (GO:0051983)3.39593679
48spindle checkpoint (GO:0031577)3.37384670
49establishment of chromosome localization (GO:0051303)3.34259564
50DNA strand elongation (GO:0022616)3.33299531
51chaperone-mediated protein complex assembly (GO:0051131)3.32972075
52regulation of centrosome cycle (GO:0046605)3.30060106
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.29031283
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.29031283
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.29031283
56negative regulation of translational initiation (GO:0045947)3.28902174
57pre-miRNA processing (GO:0031054)3.27467198
58negative regulation of mRNA processing (GO:0050686)3.27172039
59mitotic chromosome condensation (GO:0007076)3.27161279
60nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.26873440
61attachment of spindle microtubules to kinetochore (GO:0008608)3.26622204
62mitotic spindle checkpoint (GO:0071174)3.26311032
63termination of RNA polymerase II transcription (GO:0006369)3.26254259
64regulation of nucleobase-containing compound transport (GO:0032239)3.25191810
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23835081
66glycine metabolic process (GO:0006544)3.22651600
67IMP biosynthetic process (GO:0006188)3.20511708
68histone H3-K36 demethylation (GO:0070544)3.19728964
69negative regulation of mRNA metabolic process (GO:1903312)3.18698855
70DNA replication-independent nucleosome organization (GO:0034724)3.18084401
71DNA replication-independent nucleosome assembly (GO:0006336)3.18084401
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.16498152
73cellular protein complex localization (GO:0034629)3.16404180
74histone exchange (GO:0043486)3.16033534
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14300211
76regulation of DNA damage checkpoint (GO:2000001)3.13488848
77negative regulation of chromosome segregation (GO:0051985)3.13473349
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13145032
79negative regulation of sister chromatid segregation (GO:0033046)3.13145032
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.13145032
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13145032
82regulation of oxidative stress-induced neuron death (GO:1903203)3.13120235
83mitotic spindle assembly checkpoint (GO:0007094)3.12673544
84folic acid transport (GO:0015884)3.11836401
85DNA replication-dependent nucleosome organization (GO:0034723)3.11820851
86DNA replication-dependent nucleosome assembly (GO:0006335)3.11820851
87DNA replication initiation (GO:0006270)3.11258093
88spindle assembly checkpoint (GO:0071173)3.10077693
89protein localization to chromosome (GO:0034502)3.10067322
90chromatin remodeling at centromere (GO:0031055)3.08947707
91mRNA export from nucleus (GO:0006406)3.08509372
92regulation of centriole replication (GO:0046599)3.08433943
93DNA methylation involved in gamete generation (GO:0043046)3.08294427
94CENP-A containing nucleosome assembly (GO:0034080)3.06414398
95telomere maintenance via semi-conservative replication (GO:0032201)3.04703011
96sister chromatid segregation (GO:0000819)3.03107572
97negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.02565859
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01120202
99RNA export from nucleus (GO:0006405)3.00557419
100mitotic sister chromatid segregation (GO:0000070)2.99893004
101male meiosis (GO:0007140)2.98575009
102vitamin transmembrane transport (GO:0035461)2.98561914
103chromosome segregation (GO:0007059)2.98479024
104regulation of mitotic sister chromatid separation (GO:0010965)2.97204487
105regulation of mitotic sister chromatid segregation (GO:0033047)2.97204487
106regulation of sister chromatid segregation (GO:0033045)2.97204487
107histone H2A monoubiquitination (GO:0035518)2.96742004
108DNA topological change (GO:0006265)2.96022897
109negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.95390633
110DNA unwinding involved in DNA replication (GO:0006268)2.92933252
111meiotic cell cycle process (GO:1903046)2.92219608
112positive regulation of response to oxidative stress (GO:1902884)2.92199424
113positive regulation of cellular response to oxidative stress (GO:1900409)2.92199424
114synaptonemal complex assembly (GO:0007130)2.90245620
115regulation of translation in response to stress (GO:0043555)2.89516093
116mitotic G1 DNA damage checkpoint (GO:0031571)2.88990374
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88044577
118regulation of sister chromatid cohesion (GO:0007063)2.87920764
119negative regulation of fibroblast apoptotic process (GO:2000270)2.87165682
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86522599
121establishment of viral latency (GO:0019043)2.86329890
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86100295
123IMP metabolic process (GO:0046040)2.84312906
124negative regulation of mitosis (GO:0045839)2.83945425
125cell cycle G1/S phase transition (GO:0044843)2.81819409
126G1/S transition of mitotic cell cycle (GO:0000082)2.81819409
127protein refolding (GO:0042026)2.81603085
128chromatin assembly or disassembly (GO:0006333)2.81085514
129spindle assembly involved in mitosis (GO:0090307)2.79955322
130heterochromatin organization (GO:0070828)2.77206033
131negative regulation of histone methylation (GO:0031061)2.76535810
132maturation of SSU-rRNA (GO:0030490)2.76375666
133G1 DNA damage checkpoint (GO:0044783)2.76215865
134microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.75355242
135kinetochore organization (GO:0051383)2.73618838
136gene silencing by RNA (GO:0031047)2.71419346
137ATP-dependent chromatin remodeling (GO:0043044)2.68780945
138ribonucleoprotein complex biogenesis (GO:0022613)2.68765956
139mRNA transport (GO:0051028)2.66285162
140rRNA processing (GO:0006364)2.64602574
141NLS-bearing protein import into nucleus (GO:0006607)2.64543585
142rRNA modification (GO:0000154)2.63010250
143mitotic G1/S transition checkpoint (GO:0044819)2.62082416
144rRNA metabolic process (GO:0016072)2.61015386
145translesion synthesis (GO:0019985)2.60843363
146protein K6-linked ubiquitination (GO:0085020)2.60473990
147synaptonemal complex organization (GO:0070193)2.60401007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02601278
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.54222238
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.70857771
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36100506
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.25429895
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20848274
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.99872369
8AR_21909140_ChIP-Seq_LNCAP_Human2.94733554
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91661621
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69467371
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52153570
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49809848
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49367336
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46546174
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.37148308
16ZNF263_19887448_ChIP-Seq_K562_Human2.31731696
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24771657
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19240301
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15287407
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.11388667
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.10006701
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09812781
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.09078222
24VDR_23849224_ChIP-Seq_CD4+_Human2.08252839
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07213934
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99145366
27XRN2_22483619_ChIP-Seq_HELA_Human1.94677439
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91469402
29MYC_22102868_ChIP-Seq_BL_Human1.88528517
30* KDM5A_27292631_Chip-Seq_BREAST_Human1.82897236
31GABP_19822575_ChIP-Seq_HepG2_Human1.75454963
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70673522
33DCP1A_22483619_ChIP-Seq_HELA_Human1.69086176
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68267162
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.67666820
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61570415
37CIITA_25753668_ChIP-Seq_RAJI_Human1.56767430
38* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56528333
39* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52063638
40FOXP3_21729870_ChIP-Seq_TREG_Human1.50505226
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47799022
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46990867
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46919331
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45695514
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44768815
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44646556
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42089707
48* TTF2_22483619_ChIP-Seq_HELA_Human1.39486514
49ELK1_19687146_ChIP-ChIP_HELA_Human1.39121262
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37692155
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35911047
52* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35792683
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31311204
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29357733
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28237304
56TFEB_21752829_ChIP-Seq_HELA_Human1.25524052
57* CHD1_26751641_Chip-Seq_LNCaP_Human1.24676359
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22845748
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22845748
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22845748
61* CLOCK_20551151_ChIP-Seq_293T_Human1.21704621
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19545596
63* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19289518
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17413088
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15727863
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13731185
67ATF3_27146783_Chip-Seq_COLON_Human1.13361634
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12584618
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12132455
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11106514
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08638073
72* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06850615
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.06761647
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04174047
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03337503
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02370464
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.01759782
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00614623
79TP63_19390658_ChIP-ChIP_HaCaT_Human0.99754525
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98821641
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98782943
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98772199
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97978624
84WT1_19549856_ChIP-ChIP_CCG9911_Human0.97756634
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.97118599
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95528807
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94002435
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92242778
89* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90532478
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90000644
91GATA1_22025678_ChIP-Seq_K562_Human0.89288616
92REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88502447
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.87684423
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86738750
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85499944
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85387366
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84890891
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84753898
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84617760
100* NCOR1_26117541_ChIP-Seq_K562_Human0.83741886
101* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83362488
102MYC_18940864_ChIP-ChIP_HL60_Human0.83049871
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82972584
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82681901
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82157850
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81857636
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81831312
108MYB_26560356_Chip-Seq_TH1_Human0.81547565
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81369225
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80997304
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80513803
112* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80409124
113MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80059686
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79670934
115GATA6_25053715_ChIP-Seq_YYC3_Human0.79455956
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79378796
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78905480
118* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78773150
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.78747272
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77799308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26243833
2MP0003111_abnormal_nucleus_morphology4.04717046
3MP0004957_abnormal_blastocyst_morpholog3.82553958
4MP0010094_abnormal_chromosome_stability3.30876334
5MP0003077_abnormal_cell_cycle3.22590781
6MP0008057_abnormal_DNA_replication3.14537895
7MP0003123_paternal_imprinting2.72541058
8MP0010352_gastrointestinal_tract_polyps2.59673182
9MP0001730_embryonic_growth_arrest2.54788021
10MP0010307_abnormal_tumor_latency2.52256734
11MP0008007_abnormal_cellular_replicative2.27498999
12MP0002009_preneoplasia2.13566093
13MP0000350_abnormal_cell_proliferation2.08641244
14MP0004233_abnormal_muscle_weight2.06706132
15MP0008058_abnormal_DNA_repair2.03208715
16MP0005380_embryogenesis_phenotype1.94197148
17MP0001672_abnormal_embryogenesis/_devel1.94197148
18MP0003705_abnormal_hypodermis_morpholog1.93742061
19MP0003941_abnormal_skin_development1.91449678
20MP0010234_abnormal_vibrissa_follicle1.90625896
21MP0003718_maternal_effect1.84559136
22MP0005076_abnormal_cell_differentiation1.82937215
23MP0008932_abnormal_embryonic_tissue1.80243824
24MP0003984_embryonic_growth_retardation1.80119506
25MP0001697_abnormal_embryo_size1.79049832
26MP0002088_abnormal_embryonic_growth/wei1.79024465
27MP0009697_abnormal_copulation1.76174180
28MP0002396_abnormal_hematopoietic_system1.70161350
29MP0008877_abnormal_DNA_methylation1.69219801
30MP0002080_prenatal_lethality1.64729601
31MP0002086_abnormal_extraembryonic_tissu1.61763875
32MP0009672_abnormal_birth_weight1.61626458
33MP0001188_hyperpigmentation1.60070559
34MP0003786_premature_aging1.56252339
35MP0000537_abnormal_urethra_morphology1.50461749
36MP0004197_abnormal_fetal_growth/weight/1.49457069
37MP0002084_abnormal_developmental_patter1.48704516
38MP0003656_abnormal_erythrocyte_physiolo1.48594802
39MP0003567_abnormal_fetal_cardiomyocyte1.47707882
40MP0004808_abnormal_hematopoietic_stem1.41488219
41MP0002139_abnormal_hepatobiliary_system1.40907091
42MP0004264_abnormal_extraembryonic_tissu1.39018855
43MP0009840_abnormal_foam_cell1.38788572
44MP0008995_early_reproductive_senescence1.38111201
45MP0002085_abnormal_embryonic_tissue1.38109410
46MP0002877_abnormal_melanocyte_morpholog1.33843774
47MP0009053_abnormal_anal_canal1.33446383
48MP0006035_abnormal_mitochondrial_morpho1.27235065
49MP0001929_abnormal_gametogenesis1.24839525
50MP0002796_impaired_skin_barrier1.23689193
51MP0001545_abnormal_hematopoietic_system1.23622466
52MP0005397_hematopoietic_system_phenotyp1.23622466
53MP0005501_abnormal_skin_physiology1.23404090
54MP0001661_extended_life_span1.22713385
55MP0002210_abnormal_sex_determination1.19111253
56MP0009703_decreased_birth_body1.17832710
57MP0001145_abnormal_male_reproductive1.17111964
58MP0003221_abnormal_cardiomyocyte_apopto1.15265311
59MP0005365_abnormal_bile_salt1.12006879
60MP0000490_abnormal_crypts_of1.09865341
61MP0004185_abnormal_adipocyte_glucose1.09601279
62MP0000313_abnormal_cell_death1.08918395
63MP0002019_abnormal_tumor_incidence1.06007077
64MP0000653_abnormal_sex_gland1.03835153
65MP0004782_abnormal_surfactant_physiolog1.00547114
66MP0008260_abnormal_autophagy1.00088219
67MP0003453_abnormal_keratinocyte_physiol0.99772353
68MP0001243_abnormal_dermal_layer0.97010874
69MP0000358_abnormal_cell_content/0.96878368
70MP0003300_gastrointestinal_ulcer0.96838382
71MP0003890_abnormal_embryonic-extraembry0.95758397
72MP0002697_abnormal_eye_size0.95228196
73MP0000609_abnormal_liver_physiology0.94569951
74MP0005621_abnormal_cell_physiology0.94068050
75MP0005220_abnormal_exocrine_pancreas0.92681383
76MP0000627_abnormal_mammary_gland0.89488836
77MP0005666_abnormal_adipose_tissue0.88739933
78MP0005384_cellular_phenotype0.88397327
79MP0005085_abnormal_gallbladder_physiolo0.88167933
80MP0009333_abnormal_splenocyte_physiolog0.87177841
81MP0001177_atelectasis0.86965425
82MP0001727_abnormal_embryo_implantation0.86558453
83MP0000733_abnormal_muscle_development0.86193249
84MP0000647_abnormal_sebaceous_gland0.86133746
85MP0001849_ear_inflammation0.86127381
86MP0005395_other_phenotype0.85612700
87MP0001915_intracranial_hemorrhage0.85410102
88MP0005187_abnormal_penis_morphology0.84291482
89MP0000428_abnormal_craniofacial_morphol0.84058923
90MP0008789_abnormal_olfactory_epithelium0.83670491
91MP0010678_abnormal_skin_adnexa0.82444160
92MP0002269_muscular_atrophy0.81104918
93MP0003566_abnormal_cell_adhesion0.80151589
94MP0000598_abnormal_liver_morphology0.78716649
95MP0003119_abnormal_digestive_system0.77977716
96MP0006036_abnormal_mitochondrial_physio0.77633203
97MP0001756_abnormal_urination0.74226523
98MP0005389_reproductive_system_phenotype0.74082224
99MP0000377_abnormal_hair_follicle0.73756215
100MP0002092_abnormal_eye_morphology0.72716443
101MP0006292_abnormal_olfactory_placode0.72014040
102MP0003950_abnormal_plasma_membrane0.71836442
103MP0002233_abnormal_nose_morphology0.71014727
104MP0003937_abnormal_limbs/digits/tail_de0.70930603
105MP0000703_abnormal_thymus_morphology0.69798379
106MP0005670_abnormal_white_adipose0.69510998
107MP0001191_abnormal_skin_condition0.68758226
108MP0005499_abnormal_olfactory_system0.68647379
109MP0005394_taste/olfaction_phenotype0.68647379
110MP0003315_abnormal_perineum_morphology0.68114208
111MP0005023_abnormal_wound_healing0.67812273
112MP0004147_increased_porphyrin_level0.67019533
113MP0003828_pulmonary_edema0.66752576
114MP0005623_abnormal_meninges_morphology0.66403333
115MP0000747_muscle_weakness0.66256136
116MP0001216_abnormal_epidermal_layer0.65961889
117MP0003699_abnormal_female_reproductive0.65952971
118MP0001299_abnormal_eye_distance/0.65042281
119MP0003861_abnormal_nervous_system0.64372678
120MP0000383_abnormal_hair_follicle0.63264680
121MP0003698_abnormal_male_reproductive0.63243362
122MP0002161_abnormal_fertility/fecundity0.63075911
123MP0010771_integument_phenotype0.62332678
124MP0000750_abnormal_muscle_regeneration0.62242356
125MP0005375_adipose_tissue_phenotype0.62124009
126MP0003121_genomic_imprinting0.62118358
127MP0001346_abnormal_lacrimal_gland0.61828693
128MP0002160_abnormal_reproductive_system0.60842108
129MP0003115_abnormal_respiratory_system0.60028767
130MP0001293_anophthalmia0.58343259
131MP0004019_abnormal_vitamin_homeostasis0.58066148
132MP0000477_abnormal_intestine_morphology0.57607235
133MP0002722_abnormal_immune_system0.57406499
134MP0006054_spinal_hemorrhage0.56985204

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.39863191
2Chromsome breakage (HP:0040012)4.19690666
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02449161
4Carpal bone hypoplasia (HP:0001498)3.94348217
5Hyperglycinemia (HP:0002154)3.86021647
6Impulsivity (HP:0100710)3.74014460
7Breast hypoplasia (HP:0003187)3.63963797
8Entropion (HP:0000621)3.48102665
9Horizontal nystagmus (HP:0000666)3.43465350
10Microvesicular hepatic steatosis (HP:0001414)3.36769823
11Rimmed vacuoles (HP:0003805)3.30848574
12Rough bone trabeculation (HP:0100670)3.23144465
13Pelvic girdle muscle weakness (HP:0003749)3.22656790
14Papillary thyroid carcinoma (HP:0002895)3.18750412
15Hyperglycemia (HP:0003074)3.14446321
16Nephroblastoma (Wilms tumor) (HP:0002667)3.05497932
17Shoulder girdle muscle weakness (HP:0003547)2.98527973
18Degeneration of anterior horn cells (HP:0002398)2.92118528
19Abnormality of the anterior horn cell (HP:0006802)2.92118528
20Gout (HP:0001997)2.89897434
21Embryonal renal neoplasm (HP:0011794)2.85560462
22Hyperglycinuria (HP:0003108)2.80081361
23Multiple enchondromatosis (HP:0005701)2.73638477
24Amyotrophic lateral sclerosis (HP:0007354)2.71861397
25Progressive external ophthalmoplegia (HP:0000590)2.68857182
26Colon cancer (HP:0003003)2.66713330
27Type I transferrin isoform profile (HP:0003642)2.63994786
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63908905
29Abnormal protein N-linked glycosylation (HP:0012347)2.63908905
30Abnormal protein glycosylation (HP:0012346)2.63908905
31Abnormal glycosylation (HP:0012345)2.63908905
32Abnormality of the musculature of the pelvis (HP:0001469)2.62753870
33Abnormality of the hip-girdle musculature (HP:0001445)2.62753870
34Medulloblastoma (HP:0002885)2.58407111
35Gonadotropin excess (HP:0000837)2.54042181
36Secondary amenorrhea (HP:0000869)2.53937014
37Prominent nose (HP:0000448)2.52933519
38Abnormal spermatogenesis (HP:0008669)2.50089525
39Abnormality of serine family amino acid metabolism (HP:0010894)2.49081272
40Abnormality of glycine metabolism (HP:0010895)2.49081272
41Ureteral duplication (HP:0000073)2.48841154
42Abnormality of the distal phalanges of the toes (HP:0010182)2.48562437
43Aplasia/Hypoplasia of the patella (HP:0006498)2.47697546
44Biliary tract neoplasm (HP:0100574)2.47694661
45Abnormal biliary tract morphology (HP:0012440)2.45231006
46Deep philtrum (HP:0002002)2.42994425
47Patellar aplasia (HP:0006443)2.40813710
48Abnormal trabecular bone morphology (HP:0100671)2.39382001
49Oral leukoplakia (HP:0002745)2.38301877
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37742715
51Facial hemangioma (HP:0000329)2.36133447
52Progressive muscle weakness (HP:0003323)2.32516718
53Premature ovarian failure (HP:0008209)2.31720502
54Osteolytic defects of the hand bones (HP:0009699)2.30571010
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.30571010
56Cortical dysplasia (HP:0002539)2.27766808
57Abnormal lung lobation (HP:0002101)2.26679448
58Subaortic stenosis (HP:0001682)2.26407395
59Abnormality of the left ventricular outflow tract (HP:0011103)2.26407395
60Upper limb muscle weakness (HP:0003484)2.26207455
61Myelodysplasia (HP:0002863)2.25209194
62Duodenal stenosis (HP:0100867)2.21992231
63Small intestinal stenosis (HP:0012848)2.21992231
64Abnormality of serum amino acid levels (HP:0003112)2.21735436
65Cerebral hypomyelination (HP:0006808)2.20060506
66Abnormality of the preputium (HP:0100587)2.20044452
67Male infertility (HP:0003251)2.20006511
68Stillbirth (HP:0003826)2.19903806
69Meckel diverticulum (HP:0002245)2.18141938
70Neoplasm of the pancreas (HP:0002894)2.16481054
71Difficulty climbing stairs (HP:0003551)2.15765671
72Breast carcinoma (HP:0003002)2.15327528
73Oligodactyly (HP:0012165)2.15207059
74Megaloblastic anemia (HP:0001889)2.12614327
75Volvulus (HP:0002580)2.12582426
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.12547763
77Insidious onset (HP:0003587)2.11993399
78Termporal pattern (HP:0011008)2.11993399
79Atrioventricular block (HP:0001678)2.11793177
80Tetraplegia (HP:0002445)2.11033938
81Glucose intolerance (HP:0000833)2.10418075
82Enlarged penis (HP:0000040)2.09962236
83Spastic diplegia (HP:0001264)2.09418326
84Nemaline bodies (HP:0003798)2.08407773
85Curly hair (HP:0002212)2.06997098
86Abnormality of the lower motor neuron (HP:0002366)2.06995122
87Pustule (HP:0200039)2.05868496
88Impaired vibration sensation in the lower limbs (HP:0002166)2.05060219
89Short nail (HP:0001799)2.03707239
90Oligodactyly (hands) (HP:0001180)2.03459755
91Central scotoma (HP:0000603)2.03320329
92Global brain atrophy (HP:0002283)2.02241717
93Thyroid carcinoma (HP:0002890)2.01854892
94Abnormality of the umbilical cord (HP:0010881)2.01257402
95Neoplasm of the colon (HP:0100273)2.00295581
96Blepharitis (HP:0000498)1.99485074
97Poikilocytosis (HP:0004447)1.98241205
98Missing ribs (HP:0000921)1.97616901
99Proximal placement of thumb (HP:0009623)1.97347846
100Posterior subcapsular cataract (HP:0007787)1.95241569
101Abnormality of the ileum (HP:0001549)1.95140253
102Ependymoma (HP:0002888)1.95050269
103Deviation of the thumb (HP:0009603)1.94388141
104Sparse lateral eyebrow (HP:0005338)1.94135681
105Overlapping toe (HP:0001845)1.93698802
106Urinary urgency (HP:0000012)1.93654199
107Abnormality of chromosome stability (HP:0003220)1.93338517
10811 pairs of ribs (HP:0000878)1.92990113
109Abnormality of the calcaneus (HP:0008364)1.92175413
110Postnatal microcephaly (HP:0005484)1.91609506
111Microretrognathia (HP:0000308)1.91335737
112Selective tooth agenesis (HP:0001592)1.90187231
113Tetraparesis (HP:0002273)1.89526118
114Squamous cell carcinoma (HP:0002860)1.88917614
115Premature rupture of membranes (HP:0001788)1.88740540
116Cystic hygroma (HP:0000476)1.88613855
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.88115044
118Reduced antithrombin III activity (HP:0001976)1.88107439
119Irregular epiphyses (HP:0010582)1.88104619
120Autoamputation (HP:0001218)1.87979005
121Abnormality of chromosome segregation (HP:0002916)1.87556603
122Glossoptosis (HP:0000162)1.87120363
123Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86670609
124Scotoma (HP:0000575)1.86403451
125Low posterior hairline (HP:0002162)1.85677907
126Muscle fiber inclusion bodies (HP:0100299)1.85667059
127Personality changes (HP:0000751)1.85424735
128Polycythemia (HP:0001901)1.85369006
129Rectal prolapse (HP:0002035)1.84433278
130Cafe-au-lait spot (HP:0000957)1.83036404
131Abnormality of the duodenum (HP:0002246)1.82707238
132Acanthocytosis (HP:0001927)1.82517685
133Abnormal cartilage morphology (HP:0002763)1.82372536
134Exercise-induced muscle cramps (HP:0003710)1.80967335
135Absent radius (HP:0003974)1.79416585
136Acute myeloid leukemia (HP:0004808)1.79210572
137Upper motor neuron abnormality (HP:0002127)1.79183627
138Insulin-resistant diabetes mellitus (HP:0000831)1.79183066
139Increased nuchal translucency (HP:0010880)1.78508809
140Large hands (HP:0001176)1.78337181
141Increased serum pyruvate (HP:0003542)1.77004248
142Neoplasm of the adrenal cortex (HP:0100641)1.76484260
143Glioma (HP:0009733)1.76151189
144Azoospermia (HP:0000027)1.76010834
145Radioulnar synostosis (HP:0002974)1.75495632
146Rhabdomyosarcoma (HP:0002859)1.75244613
147Amniotic constriction ring (HP:0009775)1.73734492
148Abnormality of placental membranes (HP:0011409)1.73734492
149Limb-girdle muscle weakness (HP:0003325)1.72039623
150Capillary hemangiomas (HP:0005306)1.71834532
151Abnormal pancreas size (HP:0012094)1.71729698
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.71538468
153Neuroblastoma (HP:0003006)1.71481787
154Primitive neuroectodermal tumor (HP:0030065)1.71481787
155Neuroblastic tumors (HP:0004376)1.71481787
156Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.71481787
157Abnormality of subcutaneous fat tissue (HP:0001001)1.71010010
158Syringomyelia (HP:0003396)1.70458820
159Spinal cord lesions (HP:0100561)1.70458820
160Embryonal neoplasm (HP:0002898)1.70051527
161Hyperuricemia (HP:0002149)1.69848703
162Increased purine levels (HP:0004368)1.69848703
163Trismus (HP:0000211)1.69032386
164High anterior hairline (HP:0009890)1.68914309
165Horseshoe kidney (HP:0000085)1.68721186
166Ankle contracture (HP:0006466)1.68504846
167Sandal gap (HP:0001852)1.67119368
168Reduced subcutaneous adipose tissue (HP:0003758)1.66698602
169Back pain (HP:0003418)1.66604687
170Conjunctival telangiectasia (HP:0000524)1.65852652
171Abnormality of the labia minora (HP:0012880)1.65401439
172Small epiphyses (HP:0010585)1.65146689
173Hematochezia (HP:0002573)1.64565623
174Spinal muscular atrophy (HP:0007269)1.64171690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.30771791
2WEE14.06324344
3NEK23.22948805
4EIF2AK13.19800328
5EPHA22.60997349
6PLK42.57355661
7CDC72.51403872
8PBK2.44797764
9TSSK62.41112988
10BRSK22.33072012
11TRIM282.17816100
12PNCK2.17395168
13LATS12.15821702
14TTK2.07545875
15RPS6KA42.06302621
16ACVR1B2.03384939
17DYRK32.02301743
18MST41.92095679
19STK31.85964562
20CDK121.84329060
21PDK41.78397149
22PDK31.78397149
23NEK11.74990960
24SRPK11.74570646
25PLK31.73938011
26PLK11.62331153
27SCYL21.55071910
28CDK191.52531909
29PLK21.49046170
30MKNK21.47162179
31MKNK11.44037409
32TRIB31.40896041
33ALK1.40893810
34EIF2AK31.37775330
35MAP3K81.35707062
36BRSK11.34611422
37AURKB1.31850008
38TAF11.30536552
39ERBB31.29867805
40FRK1.27109174
41BCR1.26726288
42BMX1.24960968
43CAMK1G1.23638402
44CHEK21.21138775
45CDK41.14070650
46KSR11.11007658
47CDK61.09997156
48CHEK11.09870709
49EEF2K1.08585895
50SIK31.08019895
51BRAF1.06857812
52PKN21.05536950
53PDK21.05367367
54STK101.04958399
55ERBB41.04101080
56ATR1.04031884
57LATS21.02449460
58STK38L0.97614140
59PASK0.96360731
60IRAK30.96340531
61AKT30.96213510
62ZAK0.93776805
63MELK0.89474427
64MTOR0.89419221
65MAP3K120.87648009
66CDK70.85784935
67ATM0.78314900
68RPS6KB20.78241771
69MAP3K30.77725135
70PRPF4B0.77530228
71CDK20.77078826
72TESK20.75676410
73PAK40.74620723
74EIF2AK20.73725456
75AURKA0.72642753
76CDK90.72178462
77CDK80.67778435
78FLT30.65363792
79CCNB10.63126137
80NUAK10.63008701
81MST1R0.62694709
82PIM10.61809103
83NME20.61632041
84NEK90.61396552
85TAOK30.61086391
86STK160.59846165
87FGR0.59063805
88MAP3K100.58642253
89MAP3K50.58314071
90YES10.57183357
91NEK60.56428575
92RAF10.56162307
93PTK20.55758252
94PDGFRB0.54748809
95CDK10.51866702
96CSF1R0.51680251
97MAP2K30.51122208
98BRD40.51061034
99MAP3K20.50159974
100LRRK20.49099728
101CDK11A0.49086400
102* CSNK1E0.48974817
103CSNK2A20.48097455
104BMPR20.47795407
105TESK10.47568214
106BCKDK0.47389833
107MARK30.46979241
108STK40.46964486
109PAK20.44203789
110PRKCI0.43465300
111PIM20.42878705
112MAPK100.42049786
113CDK140.42019323
114KSR20.41847913
115MAP2K20.41784581
116RPS6KB10.40599180
117OXSR10.40321825
118EGFR0.40003078
119CDK180.39847442
120PTK60.39145959
121MINK10.38676429
122TAOK10.38366409
123PRKD30.38178099
124PRKDC0.36186236
125FGFR40.32976817
126RET0.32937800
127* CSNK2A10.32205148
128TGFBR10.31913632
129CDK150.31826545
130CDK30.31702070
131DYRK1B0.31072933
132AKT20.30634915
133STK240.29604996
134MET0.29228185
135FGFR30.29113180
136ABL20.28636961
137VRK10.28186269
138ZAP700.28021051
139FGFR10.27102101
140RPS6KA50.26609011
141CSNK1A1L0.26389735

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.72418119
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97874764
3* RNA transport_Homo sapiens_hsa030133.61982461
4Cell cycle_Homo sapiens_hsa041102.85327958
5RNA polymerase_Homo sapiens_hsa030202.78288888
6Spliceosome_Homo sapiens_hsa030402.67313948
7DNA replication_Homo sapiens_hsa030302.63165488
8Proteasome_Homo sapiens_hsa030502.15146612
9Mismatch repair_Homo sapiens_hsa034302.01777740
10One carbon pool by folate_Homo sapiens_hsa006701.93614067
11p53 signaling pathway_Homo sapiens_hsa041151.89159339
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88806748
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83966890
14mRNA surveillance pathway_Homo sapiens_hsa030151.83266268
15Pyrimidine metabolism_Homo sapiens_hsa002401.83080366
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80096879
17Selenocompound metabolism_Homo sapiens_hsa004501.72784771
18Nucleotide excision repair_Homo sapiens_hsa034201.70641065
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69741976
20Basal transcription factors_Homo sapiens_hsa030221.62785152
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61988225
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56605298
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56227009
24Oocyte meiosis_Homo sapiens_hsa041141.54404535
25Pentose phosphate pathway_Homo sapiens_hsa000301.51588123
26Folate biosynthesis_Homo sapiens_hsa007901.51467130
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44788997
28Base excision repair_Homo sapiens_hsa034101.42892165
29RNA degradation_Homo sapiens_hsa030181.41958307
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40793349
31Homologous recombination_Homo sapiens_hsa034401.39701234
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39496704
33Protein export_Homo sapiens_hsa030601.33718780
34Epstein-Barr virus infection_Homo sapiens_hsa051691.29620311
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27981468
36Regulation of autophagy_Homo sapiens_hsa041401.24836626
37Fanconi anemia pathway_Homo sapiens_hsa034601.24058516
38Nitrogen metabolism_Homo sapiens_hsa009101.23447463
39Antigen processing and presentation_Homo sapiens_hsa046121.18275788
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.14788573
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.08513199
42mTOR signaling pathway_Homo sapiens_hsa041501.07595678
43Fatty acid elongation_Homo sapiens_hsa000621.02139845
44Biosynthesis of amino acids_Homo sapiens_hsa012301.01880729
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00514253
46Viral carcinogenesis_Homo sapiens_hsa052030.98148760
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98129540
48Small cell lung cancer_Homo sapiens_hsa052220.94665731
49Pyruvate metabolism_Homo sapiens_hsa006200.93573767
50Thyroid cancer_Homo sapiens_hsa052160.93353636
51Purine metabolism_Homo sapiens_hsa002300.89152500
52ErbB signaling pathway_Homo sapiens_hsa040120.89019783
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.80849676
54MicroRNAs in cancer_Homo sapiens_hsa052060.77117415
55N-Glycan biosynthesis_Homo sapiens_hsa005100.75273273
56HTLV-I infection_Homo sapiens_hsa051660.72774330
57Herpes simplex infection_Homo sapiens_hsa051680.72615500
58Shigellosis_Homo sapiens_hsa051310.70386437
59FoxO signaling pathway_Homo sapiens_hsa040680.68946759
60Chronic myeloid leukemia_Homo sapiens_hsa052200.66462594
61Carbon metabolism_Homo sapiens_hsa012000.66385395
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65390520
63Non-homologous end-joining_Homo sapiens_hsa034500.64405788
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63588598
65Sulfur relay system_Homo sapiens_hsa041220.63314801
66Prostate cancer_Homo sapiens_hsa052150.63280032
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62125641
68AMPK signaling pathway_Homo sapiens_hsa041520.60925932
69Vitamin digestion and absorption_Homo sapiens_hsa049770.59709575
70Ribosome_Homo sapiens_hsa030100.58985964
71Dorso-ventral axis formation_Homo sapiens_hsa043200.58455827
72Fructose and mannose metabolism_Homo sapiens_hsa000510.57248817
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57044470
74Hippo signaling pathway_Homo sapiens_hsa043900.53757232
75Bladder cancer_Homo sapiens_hsa052190.53034064
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52064614
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51750212
78Lysine degradation_Homo sapiens_hsa003100.51674863
79Propanoate metabolism_Homo sapiens_hsa006400.48208830
80Phenylalanine metabolism_Homo sapiens_hsa003600.47353900
81Circadian rhythm_Homo sapiens_hsa047100.47293767
82Renal cell carcinoma_Homo sapiens_hsa052110.46706613
83Legionellosis_Homo sapiens_hsa051340.46278423
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46039349
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45410857
86TGF-beta signaling pathway_Homo sapiens_hsa043500.44795863
87Glutathione metabolism_Homo sapiens_hsa004800.44124244
88Hepatitis B_Homo sapiens_hsa051610.42559945
89Glioma_Homo sapiens_hsa052140.41963293
90Systemic lupus erythematosus_Homo sapiens_hsa053220.41733805
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.41434896
92Endometrial cancer_Homo sapiens_hsa052130.39696578
93Arginine and proline metabolism_Homo sapiens_hsa003300.39432698
94Colorectal cancer_Homo sapiens_hsa052100.38509844
95Adherens junction_Homo sapiens_hsa045200.38091067
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38057218
97Non-small cell lung cancer_Homo sapiens_hsa052230.37588740
98Apoptosis_Homo sapiens_hsa042100.37068230
99Wnt signaling pathway_Homo sapiens_hsa043100.36353894
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.36220107
101Caffeine metabolism_Homo sapiens_hsa002320.35936053
102Fat digestion and absorption_Homo sapiens_hsa049750.35472530
103Insulin resistance_Homo sapiens_hsa049310.35368723
104Steroid biosynthesis_Homo sapiens_hsa001000.34434531
105Glycerolipid metabolism_Homo sapiens_hsa005610.34082768
106Acute myeloid leukemia_Homo sapiens_hsa052210.33013424
107HIF-1 signaling pathway_Homo sapiens_hsa040660.30712240
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30251089
109Pancreatic cancer_Homo sapiens_hsa052120.29427447
110Tight junction_Homo sapiens_hsa045300.27736233
111Insulin signaling pathway_Homo sapiens_hsa049100.26566143
112Proteoglycans in cancer_Homo sapiens_hsa052050.26526218
113Arginine biosynthesis_Homo sapiens_hsa002200.24070301
114Prolactin signaling pathway_Homo sapiens_hsa049170.24005040
115Glucagon signaling pathway_Homo sapiens_hsa049220.23501268
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22953119
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22744682
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22418841
119Choline metabolism in cancer_Homo sapiens_hsa052310.21835133
120Huntingtons disease_Homo sapiens_hsa050160.21075292
121Renin-angiotensin system_Homo sapiens_hsa046140.20797485
122Vibrio cholerae infection_Homo sapiens_hsa051100.19903047
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.19597945
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17558997
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16942370
126Pathways in cancer_Homo sapiens_hsa052000.16022150
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13500869
128Long-term potentiation_Homo sapiens_hsa047200.13372601

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