EIF5A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)5.95280072
2synaptic vesicle maturation (GO:0016188)5.92327028
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.28953084
4behavioral response to ethanol (GO:0048149)5.27002028
5synaptic vesicle exocytosis (GO:0016079)5.25872794
6neurofilament cytoskeleton organization (GO:0060052)5.23328130
7glutamate secretion (GO:0014047)5.16056077
8regulation of synaptic vesicle exocytosis (GO:2000300)5.11075224
9neuronal action potential propagation (GO:0019227)5.02282218
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94664036
11piRNA metabolic process (GO:0034587)4.89167615
12melanin biosynthetic process (GO:0042438)4.76271765
13proteasome assembly (GO:0043248)4.52023767
14adult feeding behavior (GO:0008343)4.49783280
15locomotory exploration behavior (GO:0035641)4.49185361
16secondary metabolite biosynthetic process (GO:0044550)4.46013301
17regulation of synaptic vesicle transport (GO:1902803)4.42382284
18ether lipid metabolic process (GO:0046485)4.27824779
19negative regulation of dendrite morphogenesis (GO:0050774)4.25604173
20proline transport (GO:0015824)4.23004972
21negative regulation of cAMP-mediated signaling (GO:0043951)4.19969857
22opioid receptor signaling pathway (GO:0038003)4.19220373
23melanin metabolic process (GO:0006582)4.11515075
24neurotransmitter secretion (GO:0007269)4.10942690
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.08724942
26negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.08247238
27cell migration in hindbrain (GO:0021535)4.05978345
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.97205839
29signal peptide processing (GO:0006465)3.95754363
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.94204914
31vocalization behavior (GO:0071625)3.93137191
32regulation of acrosome reaction (GO:0060046)3.91846515
33protein localization to synapse (GO:0035418)3.90264318
34cerebellar Purkinje cell differentiation (GO:0021702)3.89996657
35cellular potassium ion homeostasis (GO:0030007)3.87868924
36layer formation in cerebral cortex (GO:0021819)3.84524444
37vesicle transport along microtubule (GO:0047496)3.82330903
38regulation of neuronal synaptic plasticity (GO:0048168)3.79499935
39neuromuscular process controlling posture (GO:0050884)3.78823953
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.78616378
41neuron cell-cell adhesion (GO:0007158)3.77839928
42sodium ion export (GO:0071436)3.77510650
43positive regulation of protein autophosphorylation (GO:0031954)3.76533370
44DNA deamination (GO:0045006)3.75582416
45membrane depolarization during action potential (GO:0086010)3.70619655
46exploration behavior (GO:0035640)3.66221503
47negative regulation of microtubule polymerization (GO:0031115)3.65285033
48response to pheromone (GO:0019236)3.65142834
49organelle transport along microtubule (GO:0072384)3.65060790
50regulation of DNA endoreduplication (GO:0032875)3.64395896
51axon cargo transport (GO:0008088)3.64244670
52regulation of protein glycosylation (GO:0060049)3.60689620
53regulation of glutamate receptor signaling pathway (GO:1900449)3.55955799
54establishment of mitochondrion localization (GO:0051654)3.55699833
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53456450
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48254631
57activation of protein kinase A activity (GO:0034199)3.47117775
58regulation of synapse structural plasticity (GO:0051823)3.45340638
59dopamine transport (GO:0015872)3.44493260
60neurotransmitter transport (GO:0006836)3.43057580
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42812778
62water-soluble vitamin biosynthetic process (GO:0042364)3.41548727
63detection of temperature stimulus (GO:0016048)3.39415545
64regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.39291491
65neuromuscular process controlling balance (GO:0050885)3.39277086
66glycine transport (GO:0015816)3.37865984
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36491286
68replication fork processing (GO:0031297)3.35190520
69regulation of hexokinase activity (GO:1903299)3.32818929
70regulation of glucokinase activity (GO:0033131)3.32818929
71detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.32722650
72detection of temperature stimulus involved in sensory perception (GO:0050961)3.32722650
73cornea development in camera-type eye (GO:0061303)3.29361122
74innervation (GO:0060384)3.29315553
75positive regulation of potassium ion transmembrane transport (GO:1901381)3.27595619
76negative regulation of DNA-dependent DNA replication (GO:2000104)3.27489037
77negative regulation of dendrite development (GO:2000171)3.27425762
78platelet dense granule organization (GO:0060155)3.26027169
79synapsis (GO:0007129)3.25929782
80synaptic vesicle endocytosis (GO:0048488)3.25074248
81neuronal action potential (GO:0019228)3.24219704
82ketone body metabolic process (GO:1902224)3.23907097
83mitochondrion transport along microtubule (GO:0047497)3.23713540
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.23713540
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23709941
86gamma-aminobutyric acid transport (GO:0015812)3.22966794
87ionotropic glutamate receptor signaling pathway (GO:0035235)3.22590568
88protein K6-linked ubiquitination (GO:0085020)3.21883579
89neuron-neuron synaptic transmission (GO:0007270)3.21506255
90RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21444148
91positive regulation of potassium ion transport (GO:0043268)3.20981929
92DNA double-strand break processing (GO:0000729)3.19150347
93positive regulation of cAMP-mediated signaling (GO:0043950)3.17315108
94sphingosine metabolic process (GO:0006670)3.15670332
95preassembly of GPI anchor in ER membrane (GO:0016254)3.15539385
96cell communication by electrical coupling (GO:0010644)3.14939331
97regulation of neurotransmitter secretion (GO:0046928)3.14868198
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11769684
99synaptic transmission, glutamatergic (GO:0035249)3.11262462
100cullin deneddylation (GO:0010388)3.10892554
101DNA replication-dependent nucleosome assembly (GO:0006335)3.09767728
102DNA replication-dependent nucleosome organization (GO:0034723)3.09767728
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06954447
104regulation of neurotransmitter levels (GO:0001505)3.06466505
105transmission of nerve impulse (GO:0019226)3.05418086
106calcium ion-dependent exocytosis (GO:0017156)3.05145267
107protein deneddylation (GO:0000338)3.04004682
108regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.02333911
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02028526
110glycerol ether metabolic process (GO:0006662)3.01811665
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00218715
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.00188447
113neuromuscular process (GO:0050905)2.98691324
114regulation of meiosis I (GO:0060631)2.98356355
115regulation of synaptic plasticity (GO:0048167)2.97654247
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97329131
117dendrite morphogenesis (GO:0048813)2.96373033
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96141638
119adult walking behavior (GO:0007628)2.94267424
120regulation of neurotransmitter transport (GO:0051588)2.93429847
121regulation of vesicle fusion (GO:0031338)2.90765523
122neuron recognition (GO:0008038)2.90567619
123glutamate receptor signaling pathway (GO:0007215)2.89787891
124regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88815423
125sphingoid metabolic process (GO:0046519)2.87635506
126membrane depolarization (GO:0051899)2.87017771
127mating behavior (GO:0007617)2.86721840
128resolution of meiotic recombination intermediates (GO:0000712)2.86435639
129neuronal ion channel clustering (GO:0045161)2.86063181
130membrane repolarization (GO:0086009)2.85201450
131dendritic spine morphogenesis (GO:0060997)2.82803216
132positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82552131
133lactate metabolic process (GO:0006089)2.81608583
134diol metabolic process (GO:0034311)2.81028533
135ether metabolic process (GO:0018904)2.80942471
136respiratory chain complex IV assembly (GO:0008535)2.80736614
137axonal fasciculation (GO:0007413)2.80257672
138prenylation (GO:0097354)2.80203089
139protein prenylation (GO:0018342)2.80203089
140recombinational repair (GO:0000725)2.80035506
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79002542
142retinal cone cell development (GO:0046549)2.78312459
143double-strand break repair via homologous recombination (GO:0000724)2.78189157
144establishment of vesicle localization (GO:0051650)2.77948111
145synaptic transmission (GO:0007268)2.77773273
146neuromuscular synaptic transmission (GO:0007274)2.77577634
147regulation of postsynaptic membrane potential (GO:0060078)2.76732217
148calcium-mediated signaling using intracellular calcium source (GO:0035584)2.76100918
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74599623
150isotype switching (GO:0045190)2.74599623
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74599623
152potassium ion homeostasis (GO:0055075)2.74215543
153positive regulation of membrane potential (GO:0045838)2.73852901
154microtubule-based transport (GO:0010970)2.72594207
155synapse assembly (GO:0007416)2.72363938
156long-term memory (GO:0007616)2.71037413
157prepulse inhibition (GO:0060134)2.70049345
158striatum development (GO:0021756)2.69980122
159regulation of neurotransmitter uptake (GO:0051580)2.69553182
160cytoskeleton-dependent intracellular transport (GO:0030705)2.69312957
161inositol phosphate catabolic process (GO:0071545)2.69058012
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68950461
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.68950461
164NADH dehydrogenase complex assembly (GO:0010257)2.68950461
165UDP-N-acetylglucosamine metabolic process (GO:0006047)2.68164025
166mitochondrial respiratory chain complex assembly (GO:0033108)2.64053299
167protein complex biogenesis (GO:0070271)2.63210533
168histone exchange (GO:0043486)2.62288535
169melanosome organization (GO:0032438)2.59178154
170ribonucleoprotein complex disassembly (GO:0032988)2.56553840
171ncRNA catabolic process (GO:0034661)2.55305333
172protein K11-linked deubiquitination (GO:0035871)2.49314087
173chromatin remodeling at centromere (GO:0031055)2.48596136
174regulation of nuclear cell cycle DNA replication (GO:0033262)2.43222343
175exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42500796
176rRNA modification (GO:0000154)2.41859605
177rRNA methylation (GO:0031167)2.41061959
178G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40056235
179mannosylation (GO:0097502)2.39368829
180maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39033976
181CENP-A containing nucleosome assembly (GO:0034080)2.36676881
182regulation of mesoderm development (GO:2000380)2.36376346
183cilium morphogenesis (GO:0060271)2.36060177
184keratinocyte development (GO:0003334)2.35680399
185smooth muscle tissue development (GO:0048745)2.34680961
186phenol-containing compound biosynthetic process (GO:0046189)2.34191080
187detection of light stimulus involved in visual perception (GO:0050908)2.33776639
188detection of light stimulus involved in sensory perception (GO:0050962)2.33776639
189pigment granule organization (GO:0048753)2.33724215
190regulation of protein autophosphorylation (GO:0031952)2.32913752
191polyol catabolic process (GO:0046174)2.31967637
192somatic recombination of immunoglobulin gene segments (GO:0016447)2.31553453
193negative regulation of neurotransmitter transport (GO:0051589)2.31355477
194negative regulation of nitric oxide biosynthetic process (GO:0045019)2.30828191
195aldehyde catabolic process (GO:0046185)2.30521911
196meiotic cell cycle (GO:0051321)2.30183008
197C-terminal protein lipidation (GO:0006501)2.29146918
198sister chromatid cohesion (GO:0007062)2.28931502
199male meiosis I (GO:0007141)2.27269778
200tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.26951095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01087956
2GBX2_23144817_ChIP-Seq_PC3_Human3.39899707
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03561353
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84704198
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83036074
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70209999
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.68062538
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.67193171
9REST_21632747_ChIP-Seq_MESCs_Mouse2.66903010
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61657670
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61657670
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.50751278
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46521039
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39293596
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38785322
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35511938
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33438774
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.32600227
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.28755912
20FUS_26573619_Chip-Seq_HEK293_Human2.26965510
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23940227
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21575875
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17639751
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.12159301
25TAF15_26573619_Chip-Seq_HEK293_Human2.10020907
26ELK1_19687146_ChIP-ChIP_HELA_Human2.08065907
27DROSHA_22980978_ChIP-Seq_HELA_Human2.07688888
28EWS_26573619_Chip-Seq_HEK293_Human2.05804168
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05228107
30* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02658965
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.00037025
32AR_21572438_ChIP-Seq_LNCaP_Human1.97665861
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.96737649
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95138222
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94576210
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.94450815
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.91904458
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90135128
39SMAD4_21799915_ChIP-Seq_A2780_Human1.86301372
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85530847
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83909417
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76780311
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76199724
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.74359849
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.71967179
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69677457
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64818832
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.63872158
49ER_23166858_ChIP-Seq_MCF-7_Human1.62246458
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61173777
51ZNF274_21170338_ChIP-Seq_K562_Hela1.60076585
52IGF1R_20145208_ChIP-Seq_DFB_Human1.59486125
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.55482878
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53856553
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53176137
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52682518
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52290913
58CBP_20019798_ChIP-Seq_JUKART_Human1.51781152
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51781152
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51763835
61* STAT3_23295773_ChIP-Seq_U87_Human1.51725375
62BCAT_22108803_ChIP-Seq_LS180_Human1.48994326
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48555853
64NANOG_19829295_ChIP-Seq_ESCs_Human1.47964228
65SOX2_19829295_ChIP-Seq_ESCs_Human1.47964228
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47686083
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46570619
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46003632
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44884507
70P300_19829295_ChIP-Seq_ESCs_Human1.44245823
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44091758
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.42987846
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42777079
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42706295
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41471846
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41101599
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38693376
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38539068
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37283643
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.36896501
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36579139
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35978873
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35789489
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35780442
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.35101966
86MYC_18940864_ChIP-ChIP_HL60_Human1.31935067
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30823153
88P53_22387025_ChIP-Seq_ESCs_Mouse1.30286322
89* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30282489
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28359629
91* CDX2_22108803_ChIP-Seq_LS180_Human1.27775052
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27481796
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26571803
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.26081027
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.24574259
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23621121
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23458945
98AR_19668381_ChIP-Seq_PC3_Human1.23421155
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.22478399
100AR_25329375_ChIP-Seq_VCAP_Human1.21831827
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20584789
102RNF2_27304074_Chip-Seq_NSC_Mouse1.20448526
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20311772
104* TCF4_23295773_ChIP-Seq_U87_Human1.20048530
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19483602
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19000555
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18460691
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18372971
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.17885436
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17326869
111P300_18555785_Chip-Seq_ESCs_Mouse1.17143605
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.16628045
113HTT_18923047_ChIP-ChIP_STHdh_Human1.15825360
114TCF4_22108803_ChIP-Seq_LS180_Human1.15302638
115TP53_22573176_ChIP-Seq_HFKS_Human1.14651085
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14083276
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13992103
118KDM2B_26808549_Chip-Seq_K562_Human1.13674181
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.13332587
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.12610563
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12364069
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12118348
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11812130
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11343557
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.10435645
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09028015
127TP53_18474530_ChIP-ChIP_U2OS_Human1.08486315
128SMAD3_21741376_ChIP-Seq_ESCs_Human1.08131561
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07377043
130AR_21909140_ChIP-Seq_LNCAP_Human1.06607362
131CJUN_26792858_Chip-Seq_BT549_Human1.06603013
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.06548640
133OCT4_18555785_Chip-Seq_ESCs_Mouse1.05942639
134RING1B_27294783_Chip-Seq_NPCs_Mouse1.05939623
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05505142
136AHR_22903824_ChIP-Seq_MCF-7_Human1.05346645
137* VDR_23849224_ChIP-Seq_CD4+_Human1.04782922
138P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04051518
139PIAS1_25552417_ChIP-Seq_VCAP_Human1.02916889
140CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02856671
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02584606
142ARNT_22903824_ChIP-Seq_MCF-7_Human1.02229958
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02082503
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01449992
145JUN_21703547_ChIP-Seq_K562_Human1.00098973
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99938304
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99493771
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.99439313
149EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98262571
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.97969337
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.95574150
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95494418
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95041101
154RUNX2_22187159_ChIP-Seq_PCA_Human0.95019612
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94464937
156RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93971341
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.93475034
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.92655373
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92530206
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91893452
161SOX9_26525672_Chip-Seq_HEART_Mouse0.91767075
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88821868
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88638362
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.87135550
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86602696
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85475698
167VDR_22108803_ChIP-Seq_LS180_Human0.85442207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.28185779
2MP0000372_irregular_coat_pigmentation4.84866671
3MP0003880_abnormal_central_pattern4.43102617
4MP0004270_analgesia4.17551911
5MP0001968_abnormal_touch/_nociception3.93475174
6MP0002735_abnormal_chemical_nociception3.82539064
7MP0002102_abnormal_ear_morphology3.58634494
8MP0003635_abnormal_synaptic_transmissio3.48153976
9MP0003136_yellow_coat_color3.36795091
10MP0002736_abnormal_nociception_after3.33713689
11MP0002734_abnormal_mechanical_nocicepti3.19236173
12MP0005408_hypopigmentation3.15070779
13MP0003195_calcinosis3.09810481
14MP0009046_muscle_twitch3.06705912
15MP0000015_abnormal_ear_pigmentation2.91389428
16MP0004858_abnormal_nervous_system2.85480932
17MP0002733_abnormal_thermal_nociception2.77540638
18MP0002064_seizures2.76097772
19MP0002063_abnormal_learning/memory/cond2.72275444
20MP0009745_abnormal_behavioral_response2.70529816
21MP0002272_abnormal_nervous_system2.68790981
22MP0002876_abnormal_thyroid_physiology2.62749308
23MP0005075_abnormal_melanosome_morpholog2.55741704
24MP0006276_abnormal_autonomic_nervous2.55140912
25MP0001970_abnormal_pain_threshold2.44571890
26MP0002938_white_spotting2.37857990
27MP0003950_abnormal_plasma_membrane2.31230496
28MP0005551_abnormal_eye_electrophysiolog2.30364193
29MP0005423_abnormal_somatic_nervous2.28244638
30MP0002572_abnormal_emotion/affect_behav2.25149415
31MP0001486_abnormal_startle_reflex2.18505577
32MP0002067_abnormal_sensory_capabilities2.16852785
33MP0002095_abnormal_skin_pigmentation2.11147650
34MP0003646_muscle_fatigue2.11053731
35MP0005174_abnormal_tail_pigmentation2.10199488
36MP0002184_abnormal_innervation2.03202162
37MP0004811_abnormal_neuron_physiology1.96047378
38MP0003329_amyloid_beta_deposits1.89440327
39MP0001440_abnormal_grooming_behavior1.85311934
40MP0000955_abnormal_spinal_cord1.83679772
41MP0001324_abnormal_eye_pigmentation1.83052596
42MP0003806_abnormal_nucleotide_metabolis1.80697672
43MP0006072_abnormal_retinal_apoptosis1.78213624
44MP0008569_lethality_at_weaning1.77543459
45MP0001501_abnormal_sleep_pattern1.76979059
46MP0000778_abnormal_nervous_system1.74723493
47MP0008057_abnormal_DNA_replication1.72751436
48MP0005253_abnormal_eye_physiology1.72540912
49MP0003941_abnormal_skin_development1.67780003
50MP0006054_spinal_hemorrhage1.62919392
51MP0005386_behavior/neurological_phenoty1.59997485
52MP0004924_abnormal_behavior1.59997485
53MP0000371_diluted_coat_color1.55693367
54MP0002822_catalepsy1.53762725
55MP0002638_abnormal_pupillary_reflex1.53539606
56MP0001986_abnormal_taste_sensitivity1.52618645
57MP0003122_maternal_imprinting1.51594780
58MP0002909_abnormal_adrenal_gland1.50340141
59MP0008058_abnormal_DNA_repair1.49486054
60MP0005503_abnormal_tendon_morphology1.48162317
61MP0002882_abnormal_neuron_morphology1.47952857
62MP0002557_abnormal_social/conspecific_i1.42584204
63MP0009780_abnormal_chondrocyte_physiolo1.40336377
64MP0001299_abnormal_eye_distance/1.38491466
65MP0002066_abnormal_motor_capabilities/c1.38362863
66MP0002090_abnormal_vision1.38340538
67MP0003633_abnormal_nervous_system1.37965839
68MP0001984_abnormal_olfaction1.37855820
69MP0003718_maternal_effect1.35878610
70MP0005623_abnormal_meninges_morphology1.35200295
71MP0010094_abnormal_chromosome_stability1.34892302
72MP0002160_abnormal_reproductive_system1.34234287
73MP0003787_abnormal_imprinting1.33116167
74MP0004142_abnormal_muscle_tone1.31704376
75MP0004381_abnormal_hair_follicle1.31136999
76MP0003283_abnormal_digestive_organ1.30501001
77MP0000427_abnormal_hair_cycle1.27930418
78MP0008877_abnormal_DNA_methylation1.25974923
79MP0002229_neurodegeneration1.22110875
80MP0001348_abnormal_lacrimal_gland1.21927997
81MP0003631_nervous_system_phenotype1.21764122
82MP0005389_reproductive_system_phenotype1.21060295
83MP0010234_abnormal_vibrissa_follicle1.20115886
84MP0000920_abnormal_myelination1.19909914
85MP0004885_abnormal_endolymph1.17631967
86MP0003634_abnormal_glial_cell1.14474233
87MP0003937_abnormal_limbs/digits/tail_de1.14075219
88MP0003879_abnormal_hair_cell1.13415404
89MP0001529_abnormal_vocalization1.11498269
90MP0002751_abnormal_autonomic_nervous1.09508019
91MP0000749_muscle_degeneration1.07053866
92MP0005646_abnormal_pituitary_gland1.06983685
93MP0001905_abnormal_dopamine_level1.04560471
94MP0006036_abnormal_mitochondrial_physio1.04155373
95MP0002152_abnormal_brain_morphology1.02190350
96MP0005645_abnormal_hypothalamus_physiol1.02129386
97MP0000647_abnormal_sebaceous_gland1.00097578
98MP0002928_abnormal_bile_duct0.99917887
99MP0004147_increased_porphyrin_level0.98764750
100MP0008775_abnormal_heart_ventricle0.98317927
101MP0000751_myopathy0.97981333
102MP0006035_abnormal_mitochondrial_morpho0.97885638
103MP0004742_abnormal_vestibular_system0.96500953
104MP0003786_premature_aging0.96382492
105MP0005195_abnormal_posterior_eye0.94358334
106MP0005197_abnormal_uvea_morphology0.94181987
107MP0003632_abnormal_nervous_system0.93909184
108MP0000516_abnormal_urinary_system0.91526610
109MP0005367_renal/urinary_system_phenotyp0.91526610
110MP0000569_abnormal_digit_pigmentation0.90855912
111MP0002752_abnormal_somatic_nervous0.90455862
112MP0005257_abnormal_intraocular_pressure0.88327446
113MP0004145_abnormal_muscle_electrophysio0.87303793
114MP0003186_abnormal_redox_activity0.85743825
115MP0003123_paternal_imprinting0.82999474
116MP0001485_abnormal_pinna_reflex0.81930073
117MP0001661_extended_life_span0.81863925
118MP0001963_abnormal_hearing_physiology0.81743272
119MP0003252_abnormal_bile_duct0.81230024
120MP0004043_abnormal_pH_regulation0.80785729
121MP0000747_muscle_weakness0.79818790
122MP0000604_amyloidosis0.79511452
123MP0002075_abnormal_coat/hair_pigmentati0.78493232
124MP0003121_genomic_imprinting0.77764238
125MP0001502_abnormal_circadian_rhythm0.77742946
126MP0004233_abnormal_muscle_weight0.75906234
127MP0002282_abnormal_trachea_morphology0.74886071
128MP0000013_abnormal_adipose_tissue0.74641509
129MP0005360_urolithiasis0.74346771
130MP0003890_abnormal_embryonic-extraembry0.74112273
131MP0003567_abnormal_fetal_cardiomyocyte0.73583270
132MP0008872_abnormal_physiological_respon0.73362774
133MP0009697_abnormal_copulation0.72752644
134MP0001188_hyperpigmentation0.72493119
135MP0001919_abnormal_reproductive_system0.71354998
136MP0005410_abnormal_fertilization0.70721533
137MP0003693_abnormal_embryo_hatching0.70095393
138MP0008875_abnormal_xenobiotic_pharmacok0.69765730
139MP0004085_abnormal_heartbeat0.69580127
140MP0010678_abnormal_skin_adnexa0.69513276
141MP0005391_vision/eye_phenotype0.68638033
142MP0001664_abnormal_digestion0.67980591
143MP0003690_abnormal_glial_cell0.67855252
144MP0005395_other_phenotype0.67281288
145MP0003045_fibrosis0.67155344
146MP0005171_absent_coat_pigmentation0.66009885
147MP0001186_pigmentation_phenotype0.65886216
148MP0005499_abnormal_olfactory_system0.65440469
149MP0005394_taste/olfaction_phenotype0.65440469
150MP0001929_abnormal_gametogenesis0.65359343
151MP0000678_abnormal_parathyroid_gland0.65127703
152MP0003861_abnormal_nervous_system0.64940218
153MP0002254_reproductive_system_inflammat0.64937362
154MP0003943_abnormal_hepatobiliary_system0.64804685
155MP0000681_abnormal_thyroid_gland0.64418013
156MP0003755_abnormal_palate_morphology0.64339233
157MP0002069_abnormal_eating/drinking_beha0.64295770
158MP0008874_decreased_physiological_sensi0.63945812
159MP0001943_abnormal_respiration0.63852443
160MP0008260_abnormal_autophagy0.61130951
161MP0000534_abnormal_ureter_morphology0.60932294
162MP0001177_atelectasis0.60130757
163MP0004484_altered_response_of0.57458928
164MP0004036_abnormal_muscle_relaxation0.55806603
165MP0005187_abnormal_penis_morphology0.55727664
166MP0002837_dystrophic_cardiac_calcinosis0.53278712
167MP0003137_abnormal_impulse_conducting0.52426366
168MP0003698_abnormal_male_reproductive0.52281343
169MP0010769_abnormal_survival0.50734609
170MP0004215_abnormal_myocardial_fiber0.50517081
171MP0010386_abnormal_urinary_bladder0.49508827

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.56187729
2Focal motor seizures (HP:0011153)5.76884530
3Thyroid-stimulating hormone excess (HP:0002925)4.93880386
4Action tremor (HP:0002345)4.91281706
5Ulnar claw (HP:0001178)4.81103350
6Focal seizures (HP:0007359)4.78349733
7Termporal pattern (HP:0011008)4.41711727
8Insidious onset (HP:0003587)4.41711727
9Volvulus (HP:0002580)4.34072824
10Atonic seizures (HP:0010819)4.32652586
11Supranuclear gaze palsy (HP:0000605)4.23392643
12Intestinal atresia (HP:0011100)4.11267807
13Visual hallucinations (HP:0002367)4.00901574
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.99442074
15Hypoplasia of the fovea (HP:0007750)3.99442074
16Progressive cerebellar ataxia (HP:0002073)3.91034262
17Congenital stationary night blindness (HP:0007642)3.91009718
18Febrile seizures (HP:0002373)3.88498960
19Pheochromocytoma (HP:0002666)3.86383587
20Ankle clonus (HP:0011448)3.76876561
21Large for gestational age (HP:0001520)3.65158781
22Absence seizures (HP:0002121)3.48338565
23Epileptic encephalopathy (HP:0200134)3.47405755
24Aplasia/Hypoplasia of the macula (HP:0008059)3.46303968
25Abnormality of the fovea (HP:0000493)3.46185157
26Neuroendocrine neoplasm (HP:0100634)3.42472356
27Urinary urgency (HP:0000012)3.30343287
28Abnormality of the ileum (HP:0001549)3.28374560
29Pancreatic islet-cell hyperplasia (HP:0004510)3.26326768
30Cutaneous melanoma (HP:0012056)3.23594737
31Aplasia/Hypoplasia affecting the retina (HP:0008061)3.20611446
32Truncal ataxia (HP:0002078)3.18213624
33Dialeptic seizures (HP:0011146)3.14728196
34Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14555348
35Generalized tonic-clonic seizures (HP:0002069)3.08821465
36Pancreatic cysts (HP:0001737)3.00100289
37Urinary bladder sphincter dysfunction (HP:0002839)2.96537696
38Abnormality of the corticospinal tract (HP:0002492)2.94109608
39Pancreatic fibrosis (HP:0100732)2.92267068
40Hammertoe (HP:0001765)2.91935777
41Impaired vibration sensation in the lower limbs (HP:0002166)2.88775630
42Abnormality of midbrain morphology (HP:0002418)2.88634487
43Molar tooth sign on MRI (HP:0002419)2.88634487
44Spastic gait (HP:0002064)2.88056818
45Segmental peripheral demyelination/remyelination (HP:0003481)2.85321616
46True hermaphroditism (HP:0010459)2.85208851
47Chromsome breakage (HP:0040012)2.85193764
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.80217613
49Depression (HP:0000716)2.77511156
50Peripheral hypomyelination (HP:0007182)2.75334216
51Poor head control (HP:0002421)2.71660155
52Gaze-evoked nystagmus (HP:0000640)2.69792052
53Scanning speech (HP:0002168)2.67291671
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.65727987
55Foot dorsiflexor weakness (HP:0009027)2.65496546
56Dysmetria (HP:0001310)2.61598138
57Gastrointestinal atresia (HP:0002589)2.55590974
58Acute necrotizing encephalopathy (HP:0006965)2.55472582
59Increased CSF lactate (HP:0002490)2.54424541
60Decreased motor nerve conduction velocity (HP:0003431)2.54372781
61Progressive macrocephaly (HP:0004481)2.53987467
62Onion bulb formation (HP:0003383)2.51713988
63Amblyopia (HP:0000646)2.51222327
64Steppage gait (HP:0003376)2.50372512
65Patchy hypopigmentation of hair (HP:0011365)2.49697105
66Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.48488648
67Meckel diverticulum (HP:0002245)2.47918708
68Congenital sensorineural hearing impairment (HP:0008527)2.46997605
69Dysdiadochokinesis (HP:0002075)2.46329394
703-Methylglutaconic aciduria (HP:0003535)2.46192977
71Lower limb muscle weakness (HP:0007340)2.45470135
72Abnormality of the lower motor neuron (HP:0002366)2.44974632
73Increased hepatocellular lipid droplets (HP:0006565)2.44520234
74Postural instability (HP:0002172)2.43625680
75Abnormality of the foot musculature (HP:0001436)2.42894594
76Neoplasm of the peripheral nervous system (HP:0100007)2.42786227
77Abnormality of macular pigmentation (HP:0008002)2.41017479
78Insomnia (HP:0100785)2.39861770
79Abnormality of chromosome stability (HP:0003220)2.38084567
80Progressive inability to walk (HP:0002505)2.37635835
81Abnormal eating behavior (HP:0100738)2.37232126
82Failure to thrive in infancy (HP:0001531)2.36632154
83Papilledema (HP:0001085)2.35398823
84Degeneration of the lateral corticospinal tracts (HP:0002314)2.34871097
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34871097
86Impaired pain sensation (HP:0007328)2.34567729
87Abnormality of pain sensation (HP:0010832)2.34567729
88Type II lissencephaly (HP:0007260)2.32987877
89Limb dystonia (HP:0002451)2.32244728
90Tubular atrophy (HP:0000092)2.30264014
91Acute encephalopathy (HP:0006846)2.28447862
92Distal sensory impairment (HP:0002936)2.26421914
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.24917231
94Methylmalonic acidemia (HP:0002912)2.24781374
95Mitochondrial inheritance (HP:0001427)2.23732197
96Impaired smooth pursuit (HP:0007772)2.23315308
97Medial flaring of the eyebrow (HP:0010747)2.23302325
98Anxiety (HP:0000739)2.23273293
99Nephronophthisis (HP:0000090)2.20737596
100Abnormality of the preputium (HP:0100587)2.19314258
101White forelock (HP:0002211)2.19150609
102Blue irides (HP:0000635)2.18873042
103Ventricular fibrillation (HP:0001663)2.18723170
104Generalized hypopigmentation (HP:0007513)2.17925840
105Decreased central vision (HP:0007663)2.17480205
106Hypothermia (HP:0002045)2.17472669
107Intention tremor (HP:0002080)2.16535203
108Renal Fanconi syndrome (HP:0001994)2.16387577
109Hypoplasia of the brainstem (HP:0002365)2.15283204
110Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15283204
111Ocular albinism (HP:0001107)2.14989100
112Abnormality of the pancreatic islet cells (HP:0006476)2.14176357
113Abnormality of endocrine pancreas physiology (HP:0012093)2.14176357
114Lipid accumulation in hepatocytes (HP:0006561)2.13588894
115Small intestinal stenosis (HP:0012848)2.13223694
116Duodenal stenosis (HP:0100867)2.13223694
117Albinism (HP:0001022)2.13157948
118Annular pancreas (HP:0001734)2.12261593
119Mutism (HP:0002300)2.11739643
120Increased corneal curvature (HP:0100692)2.11231000
121Keratoconus (HP:0000563)2.11231000
122Poor eye contact (HP:0000817)2.10898454
123Fetal akinesia sequence (HP:0001989)2.10437780
124Megalencephaly (HP:0001355)2.10211033
125Bradykinesia (HP:0002067)2.09798673
126Clonus (HP:0002169)2.09285514
127Iris hypopigmentation (HP:0007730)2.08988876
128Chronic hepatic failure (HP:0100626)2.08468335
129Congenital ichthyosiform erythroderma (HP:0007431)2.04259052
130Broad-based gait (HP:0002136)2.03656384
131Hamartoma of the eye (HP:0010568)2.03482699
132Abnormality of the renal cortex (HP:0011035)2.01693394
133Abnormal social behavior (HP:0012433)2.01673772
134Impaired social interactions (HP:0000735)2.01673772
135Postural tremor (HP:0002174)2.01336211
136Pendular nystagmus (HP:0012043)2.00283938
137Methylmalonic aciduria (HP:0012120)1.99539400
138Astigmatism (HP:0000483)1.99293586
139Abnormal mitochondria in muscle tissue (HP:0008316)1.99279273
140Agitation (HP:0000713)1.98192849
141Abnormality of the renal medulla (HP:0100957)1.96466097
142Pointed chin (HP:0000307)1.96020202
143Torticollis (HP:0000473)1.95916148
144Aqueductal stenosis (HP:0002410)1.95025348
145Hypercortisolism (HP:0001578)1.93178178
146Chorioretinal atrophy (HP:0000533)1.92230425
147Abnormality of ocular smooth pursuit (HP:0000617)1.90069150
148Abnormal drinking behavior (HP:0030082)1.89865563
149Polydipsia (HP:0001959)1.89865563
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89790425
151Abnormal auditory evoked potentials (HP:0006958)1.89378149
152Embryonal renal neoplasm (HP:0011794)1.89343134
153Cerebral inclusion bodies (HP:0100314)1.88823384
154Adrenal hypoplasia (HP:0000835)1.87648966
155Neurofibrillary tangles (HP:0002185)1.87129155
156Abnormality of the duodenum (HP:0002246)1.85621883
157Resting tremor (HP:0002322)1.85528092
158Menstrual irregularities (HP:0000858)1.85245149
159Nephroblastoma (Wilms tumor) (HP:0002667)1.84791212
160Abnormality of methionine metabolism (HP:0010901)1.84131013
161Genetic anticipation (HP:0003743)1.83608174
162Hypoventilation (HP:0002791)1.83107846
163Abnormality of the vocal cords (HP:0008777)1.83042924
164Akinesia (HP:0002304)1.82684081
165Optic nerve hypoplasia (HP:0000609)1.82453609
166Specific learning disability (HP:0001328)1.82109427
167Paraplegia (HP:0010550)1.81846175
168Lower limb asymmetry (HP:0100559)1.81809111
169Impaired vibratory sensation (HP:0002495)1.81599872
170Disproportionate short-trunk short stature (HP:0003521)1.81525023
171Epileptiform EEG discharges (HP:0011182)1.80826461
172Slow saccadic eye movements (HP:0000514)1.79996300
173Gait ataxia (HP:0002066)1.79782505
174Hemiparesis (HP:0001269)1.79563121
175EEG with generalized epileptiform discharges (HP:0011198)1.79330936
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.78734593
177Sclerocornea (HP:0000647)1.78599819
178Abnormality of saccadic eye movements (HP:0000570)1.78246754
179Retinal dysplasia (HP:0007973)1.77796718
180Rapidly progressive (HP:0003678)1.77339008
181Absent speech (HP:0001344)1.77121810
182Postaxial foot polydactyly (HP:0001830)1.75499872
183Abnormal lung lobation (HP:0002101)1.75339525
184Abnormal rod and cone electroretinograms (HP:0008323)1.75214367
185Median cleft lip (HP:0000161)1.74953577
186Congenital primary aphakia (HP:0007707)1.74166244
187Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74011328
188Hypsarrhythmia (HP:0002521)1.73808712
189Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72176669
190Clubbing of toes (HP:0100760)1.71907630
191Horizontal nystagmus (HP:0000666)1.71819232
192Aplasia/Hypoplasia of the spleen (HP:0010451)1.71701349
193Nephrogenic diabetes insipidus (HP:0009806)1.70271764
194Ketoacidosis (HP:0001993)1.70075838
195Furrowed tongue (HP:0000221)1.69300133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.98841301
2NTRK34.47939830
3ADRBK24.24157057
4MAP3K94.01328446
5MINK13.69831763
6MAP3K43.31298987
7TRIM283.14749088
8WEE13.01002863
9ACVR1B2.98535049
10EIF2AK32.95717728
11EIF2AK12.62530446
12NTRK12.60579014
13KSR22.57467647
14BMPR1B2.40485926
15MAP2K72.39649110
16LMTK22.39076138
17PAK62.34002797
18MARK12.31937391
19NUAK12.29350226
20PRKD32.18264075
21BUB12.09527304
22EPHA42.05727975
23LATS22.03359779
24PLK32.01934502
25MAP2K42.01136730
26MAP3K121.98994356
27WNK31.96502263
28MST41.93106869
29WNK11.90470739
30LIMK11.67163117
31ERBB31.66808122
32MAP3K21.65300120
33CAMKK11.61799262
34SCYL21.57659603
35MKNK21.56553888
36KSR11.55957901
37GRK11.55026620
38STK391.54482793
39BRSK21.51870048
40PLK41.51725985
41TSSK61.49178483
42RET1.44542851
43PHKG21.42708550
44PHKG11.42708550
45CDK51.41206070
46TNIK1.40627007
47STK31.38645390
48UHMK11.38302099
49PNCK1.38038081
50GRK51.36870046
51NTRK21.35888505
52CAMKK21.30824461
53ARAF1.29375452
54SGK4941.26144120
55SGK2231.26144120
56DAPK21.24644244
57LATS11.21676892
58CDK191.21031748
59PLK21.20660546
60MAPK131.19709537
61STK38L1.18763329
62RIPK41.18120788
63MAP4K21.16215358
64CASK1.13628194
65MKNK11.13014734
66TAF11.11387814
67IRAK11.11257298
68NEK11.09489549
69TGFBR11.06883773
70STK381.06743419
71CDK141.06369512
72EIF2AK21.05468080
73TGFBR21.03337370
74PRKCG0.99625535
75PDK20.98565552
76CDK180.97443409
77ZAK0.97058684
78MARK30.93175617
79OXSR10.92197603
80CDK150.91839727
81WNK40.91322644
82CSNK1G20.90312352
83TYRO30.87125445
84BCR0.82997488
85PAK30.82439129
86SGK20.80996715
87FER0.80620750
88BRSK10.80611927
89PRKCH0.78688543
90PRPF4B0.77327629
91CDK11A0.76940482
92CAMK2A0.76148667
93CSNK1G10.75987635
94PLK10.72892057
95STK110.69701336
96ALK0.69659859
97PDK30.66013561
98PDK40.66013561
99PDK10.65945378
100SGK30.65748349
101DAPK10.65279877
102MAP3K10.65137408
103CLK10.65098644
104MYLK0.64618192
105MAPK100.64438416
106TTK0.63456218
107VRK10.61431642
108PINK10.61376804
109MAP2K10.59991750
110ERBB40.58761409
111SIK30.58593021
112MST1R0.57958438
113PDPK10.57702274
114MAPKAPK50.57217722
115CDC42BPA0.56973903
116FES0.55006789
117PRKCI0.54721979
118PTK2B0.53175156
119TAOK10.50269053
120PBK0.48837482
121SGK10.48379735
122INSRR0.48145905
123CAMK2B0.47636278
124FGFR20.45875953
125ROCK20.44804182
126RPS6KA20.44354917
127MAP3K130.44241677
128CCNB10.43848984
129FLT30.43554743
130CSNK1G30.43189430
131RPS6KA30.42786101
132STK160.41912612
133PRKCE0.41130731
134DYRK1A0.41055876
135CSNK1E0.40752731
136CAMK2G0.40717771
137ATR0.40318179
138VRK20.40047457
139ATM0.39023424
140TNK20.39008457
141MARK20.38724919
142CAMK10.37635716
143CSNK1A1L0.37263816
144CHEK20.36842846
145NEK20.36833245
146MAPKAPK30.36338339
147TLK10.35853934
148FGFR10.35487435
149ADRBK10.35312505
150MELK0.35198076
151CAMK2D0.35053741
152DYRK30.34257587
153TAOK30.34164940
154CAMK1G0.33431688
155CDC70.32627404
156RAF10.32406331
157AURKB0.31854102
158MUSK0.31735808
159PKN10.31683577
160CSNK1A10.31666424
161PRKCZ0.31556412
162NEK90.31349735
163GRK70.30601028
164PRKCB0.30156040
165CSNK2A10.29359714
166IRAK30.26157358
167MET0.25936731

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.94514656
2Synaptic vesicle cycle_Homo sapiens_hsa047213.52157507
3Proteasome_Homo sapiens_hsa030503.38539246
4Nicotine addiction_Homo sapiens_hsa050332.77037717
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.70729061
6Olfactory transduction_Homo sapiens_hsa047402.70728053
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62479650
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55335076
9Basal transcription factors_Homo sapiens_hsa030222.48674161
10Long-term potentiation_Homo sapiens_hsa047202.42460129
11Homologous recombination_Homo sapiens_hsa034402.39362698
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.36738599
13Circadian entrainment_Homo sapiens_hsa047132.27566251
14GABAergic synapse_Homo sapiens_hsa047272.21813693
15Dopaminergic synapse_Homo sapiens_hsa047282.17728809
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17351832
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14386554
18Amphetamine addiction_Homo sapiens_hsa050312.11002333
19Glutamatergic synapse_Homo sapiens_hsa047242.08212140
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07076575
21Fanconi anemia pathway_Homo sapiens_hsa034602.06880341
22Oxidative phosphorylation_Homo sapiens_hsa001902.06321020
23Morphine addiction_Homo sapiens_hsa050321.98193314
24Insulin secretion_Homo sapiens_hsa049111.87960466
25Parkinsons disease_Homo sapiens_hsa050121.84551757
26Salivary secretion_Homo sapiens_hsa049701.84536628
27Taste transduction_Homo sapiens_hsa047421.79547713
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.77246334
29One carbon pool by folate_Homo sapiens_hsa006701.74783647
30Cholinergic synapse_Homo sapiens_hsa047251.74522578
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73425376
32Sulfur metabolism_Homo sapiens_hsa009201.66941946
33Gastric acid secretion_Homo sapiens_hsa049711.66230500
34Non-homologous end-joining_Homo sapiens_hsa034501.65619956
35Butanoate metabolism_Homo sapiens_hsa006501.63659605
36Propanoate metabolism_Homo sapiens_hsa006401.57806766
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56461316
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54673839
39Long-term depression_Homo sapiens_hsa047301.54021698
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53274030
41RNA degradation_Homo sapiens_hsa030181.53154756
42Selenocompound metabolism_Homo sapiens_hsa004501.50899039
43Serotonergic synapse_Homo sapiens_hsa047261.50770593
44Oocyte meiosis_Homo sapiens_hsa041141.49056623
45Dorso-ventral axis formation_Homo sapiens_hsa043201.48755423
46RNA polymerase_Homo sapiens_hsa030201.48028382
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47611574
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47119605
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.45622422
50Renin secretion_Homo sapiens_hsa049241.43285242
51Gap junction_Homo sapiens_hsa045401.42146846
52GnRH signaling pathway_Homo sapiens_hsa049121.41987228
53Cocaine addiction_Homo sapiens_hsa050301.39787750
54Oxytocin signaling pathway_Homo sapiens_hsa049211.37945746
55Collecting duct acid secretion_Homo sapiens_hsa049661.37402275
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37175482
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31205824
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27319364
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26835691
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25971576
61Glioma_Homo sapiens_hsa052141.24709454
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23461050
63Alzheimers disease_Homo sapiens_hsa050101.22889506
64Nucleotide excision repair_Homo sapiens_hsa034201.22645456
65Fatty acid elongation_Homo sapiens_hsa000621.21323512
66Calcium signaling pathway_Homo sapiens_hsa040201.20941567
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17799152
68Estrogen signaling pathway_Homo sapiens_hsa049151.17729668
69Huntingtons disease_Homo sapiens_hsa050161.17643702
70ErbB signaling pathway_Homo sapiens_hsa040121.16426505
71Cysteine and methionine metabolism_Homo sapiens_hsa002701.14705330
72Axon guidance_Homo sapiens_hsa043601.14335129
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12343878
74cAMP signaling pathway_Homo sapiens_hsa040241.11801710
75Type II diabetes mellitus_Homo sapiens_hsa049301.11672986
76Tryptophan metabolism_Homo sapiens_hsa003801.06015826
77p53 signaling pathway_Homo sapiens_hsa041151.05785406
78Vibrio cholerae infection_Homo sapiens_hsa051101.03889110
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03510423
80Steroid hormone biosynthesis_Homo sapiens_hsa001401.02977620
81Caffeine metabolism_Homo sapiens_hsa002321.02508800
82Melanogenesis_Homo sapiens_hsa049161.02025676
83Glutathione metabolism_Homo sapiens_hsa004801.00599760
84Neurotrophin signaling pathway_Homo sapiens_hsa047221.00464644
85RNA transport_Homo sapiens_hsa030131.00428038
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96416257
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.95534393
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95139881
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94174745
90Chemical carcinogenesis_Homo sapiens_hsa052040.92642604
91Sphingolipid metabolism_Homo sapiens_hsa006000.91367272
92Mismatch repair_Homo sapiens_hsa034300.91025724
93Cardiac muscle contraction_Homo sapiens_hsa042600.90804730
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90735565
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.89166878
96Vitamin B6 metabolism_Homo sapiens_hsa007500.88854647
97Endocytosis_Homo sapiens_hsa041440.86458798
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85286684
99Regulation of autophagy_Homo sapiens_hsa041400.84326633
100Linoleic acid metabolism_Homo sapiens_hsa005910.84118113
101Cell cycle_Homo sapiens_hsa041100.84062519
102Alcoholism_Homo sapiens_hsa050340.81326373
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80649314
104MAPK signaling pathway_Homo sapiens_hsa040100.80201551
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.80066918
106Purine metabolism_Homo sapiens_hsa002300.78588725
107mTOR signaling pathway_Homo sapiens_hsa041500.78521861
108Folate biosynthesis_Homo sapiens_hsa007900.77758725
109Choline metabolism in cancer_Homo sapiens_hsa052310.77055848
110VEGF signaling pathway_Homo sapiens_hsa043700.76243395
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.76239280
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76209779
113Ether lipid metabolism_Homo sapiens_hsa005650.76123298
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76116928
115Metabolic pathways_Homo sapiens_hsa011000.76038535
116Thyroid hormone synthesis_Homo sapiens_hsa049180.75604983
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73383146
118Mineral absorption_Homo sapiens_hsa049780.72809260
119TGF-beta signaling pathway_Homo sapiens_hsa043500.72522980
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71977591
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71032720
122Retinol metabolism_Homo sapiens_hsa008300.69981960
123Pyrimidine metabolism_Homo sapiens_hsa002400.68423893
124Endometrial cancer_Homo sapiens_hsa052130.68358595
125Pancreatic secretion_Homo sapiens_hsa049720.67867866
126Pyruvate metabolism_Homo sapiens_hsa006200.67309578
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66920077
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66232951
129Ras signaling pathway_Homo sapiens_hsa040140.65618881
130Inositol phosphate metabolism_Homo sapiens_hsa005620.63590984
131Glycerolipid metabolism_Homo sapiens_hsa005610.63043846
132Rap1 signaling pathway_Homo sapiens_hsa040150.63032774
133Steroid biosynthesis_Homo sapiens_hsa001000.62812733
134Renal cell carcinoma_Homo sapiens_hsa052110.62525636
135Insulin signaling pathway_Homo sapiens_hsa049100.61659911
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60973579
137Glucagon signaling pathway_Homo sapiens_hsa049220.60552878
138Nitrogen metabolism_Homo sapiens_hsa009100.60198984
139Peroxisome_Homo sapiens_hsa041460.59696291
140Sulfur relay system_Homo sapiens_hsa041220.59410128
141Fatty acid degradation_Homo sapiens_hsa000710.58926277
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58901415
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58477332
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.57337072
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56841010
146Circadian rhythm_Homo sapiens_hsa047100.56179731
147ABC transporters_Homo sapiens_hsa020100.54182336
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.54140654
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53343595
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52617728
151Hedgehog signaling pathway_Homo sapiens_hsa043400.52423752
152Phototransduction_Homo sapiens_hsa047440.52312222
153Dilated cardiomyopathy_Homo sapiens_hsa054140.52136410
154beta-Alanine metabolism_Homo sapiens_hsa004100.52086237
155Colorectal cancer_Homo sapiens_hsa052100.50897727
156Non-small cell lung cancer_Homo sapiens_hsa052230.49653119
157Salmonella infection_Homo sapiens_hsa051320.49432364
158Melanoma_Homo sapiens_hsa052180.48851457
159DNA replication_Homo sapiens_hsa030300.48023719
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47781828
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46352736
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46247262
163Wnt signaling pathway_Homo sapiens_hsa043100.45852175
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44467544
165Prolactin signaling pathway_Homo sapiens_hsa049170.42505759
166Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41971082
167Tight junction_Homo sapiens_hsa045300.41786124
168Prion diseases_Homo sapiens_hsa050200.40400796
169Thyroid cancer_Homo sapiens_hsa052160.40049978
170Starch and sucrose metabolism_Homo sapiens_hsa005000.40010195
171Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39791776
172Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39398803
173Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37240644
174Hippo signaling pathway_Homo sapiens_hsa043900.36066516
175N-Glycan biosynthesis_Homo sapiens_hsa005100.35764695
176Phagosome_Homo sapiens_hsa041450.34036431
177Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33143397
178Type I diabetes mellitus_Homo sapiens_hsa049400.32969493

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