ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	8.47546618
2	hemoglobin metabolic process (GO:0020027)	8.15075528
3	peptide catabolic process (GO:0043171)	6.81002577
4	thyroid hormone generation (GO:0006590)	6.78052797
5	neutrophil activation involved in immune response (GO:0002283)	6.50478071
6	thyroid hormone metabolic process (GO:0042403)	5.92538071
7	response to zinc ion (GO:0010043)	5.54318784
8	response to cadmium ion (GO:0046686)	5.12696025
9	removal of superoxide radicals (GO:0019430)	4.62206003
10	cellular response to superoxide (GO:0071451)	4.62206003
11	cellular response to oxygen radical (GO:0071450)	4.62206003
12	response to oxygen radical (GO:0000305)	4.55483253
13	negative regulation of fibroblast apoptotic process (GO:2000270)	4.48620988
14	response to superoxide (GO:0000303)	4.45094402
15	autophagic vacuole fusion (GO:0000046)	4.30610846
16	regulation of DNA methylation (GO:0044030)	4.27826831
17	rRNA catabolic process (GO:0016075)	4.21274985
18	cullin deneddylation (GO:0010388)	4.20366323
19	organelle membrane fusion (GO:0090174)	4.00001042
20	prepulse inhibition (GO:0060134)	3.87636896
21	response to copper ion (GO:0046688)	3.85253340
22	protein localization to cilium (GO:0061512)	3.70215920
23	hydrogen peroxide catabolic process (GO:0042744)	3.69361729
24	protein deneddylation (GO:0000338)	3.66820192
25	proteasome assembly (GO:0043248)	3.51927208
26	regulation of fibroblast apoptotic process (GO:2000269)	3.41811044
27	monocyte differentiation (GO:0030224)	3.39847492
28	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.36303150
29	serine transport (GO:0032329)	3.23954734
30	DNA replication checkpoint (GO:0000076)	3.22303727
31	protein-cofactor linkage (GO:0018065)	3.19905858
32	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.09539922
33	synaptic transmission, cholinergic (GO:0007271)	3.09190600
34	spliceosomal tri-snRNP complex assembly (GO:0000244)	3.09129646
35	platelet dense granule organization (GO:0060155)	3.08807286
36	adaptation of signaling pathway (GO:0023058)	3.03896237
37	neutrophil activation (GO:0042119)	3.02972935
38	regulation of memory T cell differentiation (GO:0043380)	3.02661810
39	oxygen transport (GO:0015671)	23.1153712
40	regulation of protein polyubiquitination (GO:1902914)	2.99168500
41	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.92702762
42	fucose catabolic process (GO:0019317)	2.87636391
43	L-fucose metabolic process (GO:0042354)	2.87636391
44	L-fucose catabolic process (GO:0042355)	2.87636391
45	xenobiotic catabolic process (GO:0042178)	2.83989130
46	negative regulation of T-helper cell differentiation (GO:0045623)	2.78474094
47	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.78474094
48	intracellular pH reduction (GO:0051452)	2.75377184
49	tissue regeneration (GO:0042246)	2.72407486
50	inositol phosphate dephosphorylation (GO:0046855)	2.70427180
51	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.70427180
52	female gonad development (GO:0008585)	2.67224173
53	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2.67079133
54	activation of Rho GTPase activity (GO:0032862)	2.65461216
55	signal peptide processing (GO:0006465)	2.65389117
56	cytoplasmic mRNA processing body assembly (GO:0033962)	2.64435373
57	mRNA modification (GO:0016556)	2.62710027
58	phagocytosis, engulfment (GO:0006911)	2.62360534
59	inositol phosphate catabolic process (GO:0071545)	2.61597155
60	adenosine metabolic process (GO:0046085)	2.59706160
61	membrane invagination (GO:0010324)	2.57041159
62	cellular biogenic amine catabolic process (GO:0042402)	2.55956865
63	amine catabolic process (GO:0009310)	2.55956865
64	pentose metabolic process (GO:0019321)	2.54920168
65	granulocyte activation (GO:0036230)	2.52675770
66	glycerophospholipid catabolic process (GO:0046475)	2.52361199
67	cellular response to sterol (GO:0036315)	2.51742911
68	leukocyte degranulation (GO:0043299)	2.50557491
69	DNA methylation involved in gamete generation (GO:0043046)	2.50353278
70	somatic diversification of immunoglobulins (GO:0016445)	2.47697699
71	regulation of cilium movement (GO:0003352)	2.47520290
72	negative regulation of anoikis (GO:2000811)	2.46775348
73	retinal metabolic process (GO:0042574)	2.46012047
74	left/right axis specification (GO:0070986)	2.45503842
75	artery smooth muscle contraction (GO:0014824)	2.42738911
76	hydrogen peroxide metabolic process (GO:0042743)	2.39070193
77	lactate metabolic process (GO:0006089)	2.37190310
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.34816410
79	polyol catabolic process (GO:0046174)	2.34804546
80	response to transition metal nanoparticle (GO:1990267)	2.29059010
81	positive regulation of catenin import into nucleus (GO:0035413)	2.28084398
82	positive regulation of NIK/NF-kappaB signaling (GO:1901224)	2.27945492
83	chondroitin sulfate catabolic process (GO:0030207)	2.26400162
84	S-adenosylmethionine metabolic process (GO:0046500)	2.25948727
85	T-helper cell differentiation (GO:0042093)	2.21848119
86	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.21848119
87	cellular response to metal ion (GO:0071248)	2.21820125
88	behavioral response to nicotine (GO:0035095)	2.21571658
89	labyrinthine layer development (GO:0060711)	2.20849259
90	T cell differentiation involved in immune response (GO:0002292)	2.20401734
91	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.20401734
92	alpha-beta T cell activation involved in immune response (GO:0002287)	2.20401734
93	peptidyl-histidine modification (GO:0018202)	2.20270074
94	negative regulation of B cell proliferation (GO:0030889)	2.19173363
95	prenylation (GO:0097354)	2.18753409
96	protein prenylation (GO:0018342)	2.18753409
97	gas transport (GO:0015669)	18.4399802
98	cellular response to zinc ion (GO:0071294)	16.5545264
99	cellular response to cadmium ion (GO:0071276)	13.5207607
100	erythrocyte maturation (GO:0043249)	10.1588156

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	5.28915579
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.05719330
3	VDR_22108803_ChIP-Seq_LS180_Human	3.77456155
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.07255323
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58660222
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.39311431
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08566313
8	TP53_22573176_ChIP-Seq_HFKS_Human	2.07112212
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.05097536
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03273276
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00043207
12	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.96283794
13	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.96283794
14	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.96283794
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.91173461
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90628799
17	P300_19829295_ChIP-Seq_ESCs_Human	1.89695368
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.83031378
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83031378
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.80907195
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75644150
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73823175
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64562563
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.60630675
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59195104
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.52880931
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50297857
28	EWS_26573619_Chip-Seq_HEK293_Human	1.50189198
29	STAT3_23295773_ChIP-Seq_U87_Human	1.45822749
30	TCF4_23295773_ChIP-Seq_U87_Human	1.45720224
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45000738
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.45000738
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44761539
34	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.42242816
35	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.41737300
36	GATA1_19941826_ChIP-Seq_K562_Human	1.41677332
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41323255
38	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.40022433
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39748071
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36785475
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36226705
42	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.34569957
43	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.34459960
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34358462
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.32821180
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32612490
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32531326
48	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.32512228
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.31895946
50	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.31266208
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.30739415
52	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.29433837
53	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.28741459
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28648221
55	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.28373720
56	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28248042
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.27302377
58	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.27212942
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26706377
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25314853
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25242622
62	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.23438243
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20911962
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20911962
65	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20811279
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.18724658
67	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.18413923
68	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.18413923
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17609646
70	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.17384465
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16855495
72	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16765473
73	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.16011565
74	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.15835511
75	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15178083
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13900909
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.13855708
78	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.13759288
79	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12499146
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.12295313
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12125131
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11624563
83	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.09213544
84	P300_18555785_Chip-Seq_ESCs_Mouse	1.08249183
85	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07707882
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07185536
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06842136
88	GATA2_19941826_ChIP-Seq_K562_Human	1.06768625
89	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.04666993
90	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.03486798
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03221111
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03119512
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02450331
94	PU1_27457419_Chip-Seq_LIVER_Mouse	1.01653612
95	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01369958
96	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01369958
97	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01031610
98	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00997081
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00897735
100	JUN_21703547_ChIP-Seq_K562_Human	1.00865916

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	7.23895975
2	MP0005377_hearing/vestibular/ear_phenot	7.23895975
3	MP0001485_abnormal_pinna_reflex	3.84367960
4	MP0008995_early_reproductive_senescence	3.81903575
5	MP0002837_dystrophic_cardiac_calcinosis	3.53906507
6	MP0001984_abnormal_olfaction	3.25627564
7	MP0005645_abnormal_hypothalamus_physiol	3.22104189
8	MP0003195_calcinosis	3.03516378
9	MP0003186_abnormal_redox_activity	2.81230084
10	MP0001879_abnormal_lymphatic_vessel	2.32449161
11	MP0004145_abnormal_muscle_electrophysio	2.29316343
12	MP0005551_abnormal_eye_electrophysiolog	2.15760023
13	MP0003136_yellow_coat_color	2.05269045
14	MP0002090_abnormal_vision	2.00322868
15	MP0004381_abnormal_hair_follicle	1.85218107
16	MP0001529_abnormal_vocalization	1.80394060
17	MP0004742_abnormal_vestibular_system	1.75084760
18	MP0008875_abnormal_xenobiotic_pharmacok	1.74111725
19	MP0001986_abnormal_taste_sensitivity	1.71204550
20	MP0005253_abnormal_eye_physiology	1.59096966
21	MP0003011_delayed_dark_adaptation	1.57339348
22	MP0003567_abnormal_fetal_cardiomyocyte	1.56576289
23	MP0005187_abnormal_penis_morphology	1.53380135
24	MP0003172_abnormal_lysosome_physiology	1.48534782
25	MP0000372_irregular_coat_pigmentation	1.44927790
26	MP0001486_abnormal_startle_reflex	1.44065653
27	MP0001958_emphysema	1.42199210
28	MP0004858_abnormal_nervous_system	1.39742602
29	MP0003656_abnormal_erythrocyte_physiolo	1.38819928
30	MP0002102_abnormal_ear_morphology	1.33506295
31	MP0008775_abnormal_heart_ventricle	1.31479402
32	MP0008872_abnormal_physiological_respon	1.31213113
33	MP0004215_abnormal_myocardial_fiber	1.29454152
34	MP0008877_abnormal_DNA_methylation	1.24116610
35	MP0005647_abnormal_sex_gland	1.23655432
36	MP0004147_increased_porphyrin_level	1.16259057
37	MP0005408_hypopigmentation	1.14302971
38	MP0004134_abnormal_chest_morphology	1.12893886
39	MP0005248_abnormal_Harderian_gland	1.09886023
40	MP0002938_white_spotting	1.07807743
41	MP0002638_abnormal_pupillary_reflex	1.07036932
42	MP0003119_abnormal_digestive_system	1.06221942
43	MP0008789_abnormal_olfactory_epithelium	1.05236600
44	MP0003786_premature_aging	1.04637895
45	MP0001293_anophthalmia	1.04325921
46	MP0005636_abnormal_mineral_homeostasis	1.03076347
47	MP0000516_abnormal_urinary_system	1.02773610
48	MP0005367_renal/urinary_system_phenotyp	1.02773610
49	MP0004019_abnormal_vitamin_homeostasis	1.01933889
50	MP0003137_abnormal_impulse_conducting	0.99314111
51	MP0005075_abnormal_melanosome_morpholog	0.95398671
52	MP0006072_abnormal_retinal_apoptosis	0.91611614
53	MP0005391_vision/eye_phenotype	0.88473192
54	MP0002972_abnormal_cardiac_muscle	0.88121483
55	MP0003806_abnormal_nucleotide_metabolis	0.87971097
56	MP0002736_abnormal_nociception_after	0.86587371
57	MP0004885_abnormal_endolymph	0.85888784
58	MP0001299_abnormal_eye_distance/	0.85535019
59	MP0000427_abnormal_hair_cycle	0.85425636
60	MP0003890_abnormal_embryonic-extraembry	0.85223720
61	MP0004142_abnormal_muscle_tone	0.84805600
62	MP0004957_abnormal_blastocyst_morpholog	0.84663018
63	MP0000647_abnormal_sebaceous_gland	0.83389848
64	MP0001501_abnormal_sleep_pattern	0.82778337
65	MP0003122_maternal_imprinting	0.81040425
66	MP0002733_abnormal_thermal_nociception	0.81032745
67	MP0001440_abnormal_grooming_behavior	0.78517615
68	MP0003385_abnormal_body_wall	0.77287790
69	MP0005646_abnormal_pituitary_gland	0.76907146
70	MP0003252_abnormal_bile_duct	0.75583405
71	MP0003959_abnormal_lean_body	0.75084486
72	MP0002928_abnormal_bile_duct	0.74226051
73	MP0004085_abnormal_heartbeat	0.73220562
74	MP0001970_abnormal_pain_threshold	0.71330611
75	MP0001968_abnormal_touch/_nociception	0.70760303
76	MP0002909_abnormal_adrenal_gland	0.70493646
77	MP0001119_abnormal_female_reproductive	0.69860387
78	MP0002229_neurodegeneration	0.69712596
79	MP0002272_abnormal_nervous_system	0.67440635
80	MP0001963_abnormal_hearing_physiology	0.65710127
81	MP0003123_paternal_imprinting	0.65068077
82	MP0000631_abnormal_neuroendocrine_gland	0.63815968
83	MP0000013_abnormal_adipose_tissue	0.63630027
84	MP0006036_abnormal_mitochondrial_physio	0.62957481
85	MP0002135_abnormal_kidney_morphology	0.62835817
86	MP0005195_abnormal_posterior_eye	0.62606402
87	MP0001944_abnormal_pancreas_morphology	0.61788952
88	MP0002557_abnormal_social/conspecific_i	0.61428151
89	MP0009765_abnormal_xenobiotic_induced	0.59450739
90	MP0003121_genomic_imprinting	0.59269788
91	MP0010329_abnormal_lipoprotein_level	0.57676238
92	MP0005197_abnormal_uvea_morphology	0.57323402
93	MP0002572_abnormal_emotion/affect_behav	0.54997166
94	MP0002092_abnormal_eye_morphology	0.54457791
95	MP0003868_abnormal_feces_composition	0.54064557
96	MP0005620_abnormal_muscle_contractility	0.53646998
97	MP0001502_abnormal_circadian_rhythm	0.52984048
98	MP0005174_abnormal_tail_pigmentation	0.52976344
99	MP0001835_abnormal_antigen_presentation	0.52721742
100	MP0005394_taste/olfaction_phenotype	0.52689089

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.88263464
2	Conjunctival hamartoma (HP:0100780)	5.22142933
3	Stomach cancer (HP:0012126)	4.95494278
4	Stillbirth (HP:0003826)	4.88085965
5	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.77630984
6	Hamartoma of the eye (HP:0010568)	4.76382484
7	Chromsome breakage (HP:0040012)	4.35889577
8	Subacute progressive viral hepatitis (HP:0006572)	4.24293720
9	Large earlobe (HP:0009748)	4.08400771
10	Progressive macrocephaly (HP:0004481)	3.71379905
11	Bone cyst (HP:0012062)	3.70294062
12	Meningioma (HP:0002858)	3.67843011
13	Chronic hepatic failure (HP:0100626)	3.51578974
14	Bilateral microphthalmos (HP:0007633)	3.44231923
15	Megalencephaly (HP:0001355)	3.28759994
16	Angiofibromas (HP:0010615)	3.14430529
17	Adenoma sebaceum (HP:0009720)	3.14430529
18	Hypochromic microcytic anemia (HP:0004840)	3.13141996
19	Visceral angiomatosis (HP:0100761)	2.91098086
20	Medulloblastoma (HP:0002885)	2.89788242
21	Alveolar cell carcinoma (HP:0006519)	2.86069694
22	Nephroblastoma (Wilms tumor) (HP:0002667)	2.85799636
23	Aplastic anemia (HP:0001915)	2.85554567
24	Overgrowth (HP:0001548)	2.82285477
25	Hemangiomatosis (HP:0007461)	2.80194446
26	Embryonal renal neoplasm (HP:0011794)	2.75302372
27	Scotoma (HP:0000575)	2.73379331
28	Glioma (HP:0009733)	2.63162508
29	Micronodular cirrhosis (HP:0001413)	2.52557439
30	Neoplasm of the tracheobronchial system (HP:0100552)	2.50469397
31	Morphological abnormality of the middle ear (HP:0008609)	2.50003776
32	Goiter (HP:0000853)	2.45571211
33	Biliary tract neoplasm (HP:0100574)	2.42114967
34	Abnormality of the septum pellucidum (HP:0007375)	2.27137243
35	Hepatocellular carcinoma (HP:0001402)	2.26617367
36	Toxemia of pregnancy (HP:0100603)	2.26572141
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20329864
38	Hamartoma (HP:0010566)	2.17047402
39	Median cleft lip (HP:0000161)	2.16645994
40	Furrowed tongue (HP:0000221)	2.15924431
41	Tongue fasciculations (HP:0001308)	2.15197966
42	Absent eyebrow (HP:0002223)	2.13644923
43	Neoplasm of the heart (HP:0100544)	2.09414805
44	Polyphagia (HP:0002591)	2.07554060
45	Lower limb asymmetry (HP:0100559)	2.07252564
46	Hepatocellular necrosis (HP:0001404)	2.05304094
47	Cavernous hemangioma (HP:0001048)	2.05216141
48	Hepatic necrosis (HP:0002605)	2.04413136
49	Microcytic anemia (HP:0001935)	2.03725681
50	Gonadal dysgenesis (HP:0000133)	2.01693228
51	Meckel diverticulum (HP:0002245)	2.01543339
52	Abnormal hemoglobin (HP:0011902)	15.4424255
53	Anterior segment dysgenesis (HP:0007700)	1.99239581
54	Abnormality of chromosome stability (HP:0003220)	1.99049285
55	Fibroma (HP:0010614)	1.98966405
56	Late onset (HP:0003584)	1.96497415
57	Ketoacidosis (HP:0001993)	1.95472906
58	Fibrous tissue neoplasm (HP:0012316)	1.94581791
59	Viral hepatitis (HP:0006562)	1.93509857
60	Pallor (HP:0000980)	1.93505225
61	Breast carcinoma (HP:0003002)	1.92230853
62	Insulin-resistant diabetes mellitus (HP:0000831)	1.91833076
63	Depressed nasal tip (HP:0000437)	1.89040923
64	Testicular neoplasm (HP:0010788)	1.88134062
65	Germ cell neoplasia (HP:0100728)	1.85946849
66	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84923714
67	Abnormality of the pancreatic islet cells (HP:0006476)	1.84923714
68	Abnormality of midbrain morphology (HP:0002418)	1.82100701
69	Molar tooth sign on MRI (HP:0002419)	1.82100701
70	Abnormality of the ileum (HP:0001549)	1.80338472
71	Muscle fibrillation (HP:0010546)	1.79526625
72	Ectopic kidney (HP:0000086)	1.77798320
73	Neoplasm of the liver (HP:0002896)	1.76921657
74	Acute necrotizing encephalopathy (HP:0006965)	1.76014028
75	Ovarian neoplasm (HP:0100615)	1.75401314
76	Tubulointerstitial nephritis (HP:0001970)	1.72429858
77	Embryonal neoplasm (HP:0002898)	1.72183933
78	Benign neoplasm of the central nervous system (HP:0100835)	1.71417977
79	Dyschromatopsia (HP:0007641)	1.71359846
80	Neoplasm of the small intestine (HP:0100833)	1.68950959
81	Multiple enchondromatosis (HP:0005701)	1.68322736
82	Abnormality of the preputium (HP:0100587)	1.68277186
83	Abnormality of the carotid arteries (HP:0005344)	1.66010676
84	Midline defect of the nose (HP:0004122)	1.64829191
85	Mucosal telangiectasiae (HP:0100579)	1.61946752
86	Arteriovenous malformation (HP:0100026)	1.61918375
87	Abnormal biliary tract morphology (HP:0012440)	1.61645102
88	Neoplasm of the rectum (HP:0100743)	1.60056311
89	Abnormality of B cell number (HP:0010975)	1.58788060
90	Duplicated collecting system (HP:0000081)	1.58184796
91	Mitochondrial inheritance (HP:0001427)	1.57861596
92	Pancreatic islet-cell hyperplasia (HP:0004510)	1.57471324
93	Hypothermia (HP:0002045)	1.54606248
94	Cerebral palsy (HP:0100021)	1.54504199
95	Hypoglycemic coma (HP:0001325)	1.51733312
96	Facial cleft (HP:0002006)	1.51680852
97	Transitional cell carcinoma of the bladder (HP:0006740)	1.49892540
98	Prominent supraorbital ridges (HP:0000336)	1.48205558
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.47739476
100	Abnormal drinking behavior (HP:0030082)	1.47671672

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.84055391
2	MAP3K4	4.39625482
3	EIF2AK1	4.11248300
4	MKNK2	4.08310991
5	CASK	3.82188628
6	MAP3K12	3.44771408
7	BMPR1B	2.81899964
8	MKNK1	2.58118862
9	AKT3	2.43730403
10	MAP2K4	2.17888339
11	FGFR2	2.07250658
12	ACVR1B	1.83969432
13	MAP3K13	1.74735080
14	TIE1	1.62879821
15	EPHA3	1.61214120
16	PHKG2	1.60976274
17	PHKG1	1.60976274
18	GRK1	1.50643423
19	MAP2K6	1.47647626
20	ADRBK2	1.46294899
21	CDC7	1.41914965
22	MAP2K3	1.40965431
23	MAP3K6	1.40040286
24	TESK1	1.33369041
25	ABL2	1.33363985
26	LIMK1	1.32518383
27	MAP3K7	1.31804095
28	MST4	1.28176568
29	NTRK3	1.27320895
30	WNK3	1.21762491
31	TRPM7	1.21627894
32	MAP3K10	1.17675113
33	STK39	1.12760057
34	EIF2AK3	1.02942004
35	PIK3CA	1.00341780
36	MAP3K2	0.99509755
37	MYLK	0.99356786
38	PTK2B	0.97171585
39	OXSR1	0.94012463
40	NEK1	0.93908155
41	CSNK1G2	0.93566328
42	ILK	0.93305909
43	IRAK1	0.88938665
44	ADRBK1	0.88896127
45	MAP4K2	0.87584180
46	PINK1	0.86238908
47	MAPKAPK5	0.86154896
48	INSRR	0.84521197
49	PLK2	0.77476203
50	MAPKAPK3	0.72100721
51	BRD4	0.71644603
52	ZAK	0.71191739
53	PRKAA2	0.67901522
54	MAP3K14	0.67824688
55	CLK1	0.67370149
56	TYRO3	0.62564433
57	PKN1	0.61796853
58	IKBKB	0.61725869
59	DYRK1B	0.60690806
60	CAMK1	0.60437078
61	PRKD2	0.60400244
62	LMTK2	0.59321035
63	DAPK2	0.57321887
64	PRKCE	0.57170534
65	CAMK1D	0.56712631
66	GRK6	0.54665261
67	PRKCQ	0.54441633
68	MET	0.54059330
69	PASK	0.52821100
70	FGFR1	0.52036078
71	KSR1	0.50422845
72	CSF1R	0.48894904
73	NUAK1	0.48267497
74	TGFBR1	0.47262688
75	MARK3	0.46731007
76	CSNK1G1	0.46637411
77	PRKD1	0.46034804
78	CSNK1A1L	0.46002269
79	TLK1	0.45317836
80	PRKG1	0.40278869
81	PLK4	0.39469831
82	WNK4	0.39141171
83	ROCK1	0.38429501
84	STK10	0.37836581
85	MAP4K1	0.37779019
86	ITK	0.37724369
87	CSNK1G3	0.36662055
88	PAK3	0.36403098
89	MINK1	0.34510524
90	ERBB2	0.32269040
91	OBSCN	0.32115210
92	RET	0.31507081
93	CAMK2A	0.29919584
94	PAK6	0.29079938
95	FGFR3	0.28901285
96	PRKCG	0.28510814
97	MAPK13	0.26686249
98	TEC	0.26060887
99	YES1	0.25823790
100	TNK2	0.25075950

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mineral absorption_Homo sapiens_hsa04978	6.73336857
2	Protein export_Homo sapiens_hsa03060	3.62863525
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74651172
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.39213291
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.29916072
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28391978
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12982812
8	Phototransduction_Homo sapiens_hsa04744	2.07806452
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03417551
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.98920586
11	Nicotine addiction_Homo sapiens_hsa05033	1.92747128
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.87102141
13	Malaria_Homo sapiens_hsa05144	1.80282317
14	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.76390023
15	Parkinsons disease_Homo sapiens_hsa05012	1.69378162
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68010093
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56082677
18	Butanoate metabolism_Homo sapiens_hsa00650	1.53848860
19	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.51718375
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41975348
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.41563269
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40509605
23	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.40474298
24	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.39619657
25	Retinol metabolism_Homo sapiens_hsa00830	1.38752116
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.31867623
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.29308451
28	Regulation of autophagy_Homo sapiens_hsa04140	1.28218489
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.27950914
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26414523
31	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.25346514
32	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.23883174
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20222194
34	Homologous recombination_Homo sapiens_hsa03440	1.14255231
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.12168185
36	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.09729316
37	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.08956917
38	Type II diabetes mellitus_Homo sapiens_hsa04930	1.07613391
39	Asthma_Homo sapiens_hsa05310	1.00157634
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99258636
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95942871
42	Bile secretion_Homo sapiens_hsa04976	0.95210269
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94631132
44	Alzheimers disease_Homo sapiens_hsa05010	0.90803952
45	ABC transporters_Homo sapiens_hsa02010	0.89084751
46	Endometrial cancer_Homo sapiens_hsa05213	0.88972533
47	Peroxisome_Homo sapiens_hsa04146	0.84802055
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.81354198
49	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.80541936
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.79206647
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77871998
52	mTOR signaling pathway_Homo sapiens_hsa04150	0.77267961
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75992315
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75499780
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.75404776
56	Huntingtons disease_Homo sapiens_hsa05016	0.74940690
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74535699
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74157510
59	Serotonergic synapse_Homo sapiens_hsa04726	0.72923720
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70506064
61	Allograft rejection_Homo sapiens_hsa05330	0.67815146
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67210918
63	Caffeine metabolism_Homo sapiens_hsa00232	0.66391335
64	Olfactory transduction_Homo sapiens_hsa04740	0.62384234
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.61286415
66	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.60966532
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.57097388
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53391322
69	Taste transduction_Homo sapiens_hsa04742	0.52585172
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.50907604
71	Acute myeloid leukemia_Homo sapiens_hsa05221	0.50196278
72	Salivary secretion_Homo sapiens_hsa04970	0.49554232
73	Melanoma_Homo sapiens_hsa05218	0.47707480
74	Platelet activation_Homo sapiens_hsa04611	0.47061945
75	Fatty acid degradation_Homo sapiens_hsa00071	0.46758201
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46033694
77	African trypanosomiasis_Homo sapiens_hsa05143	0.45608084
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.44924477
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44508135
80	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41922439
81	VEGF signaling pathway_Homo sapiens_hsa04370	0.38726764
82	Hepatitis C_Homo sapiens_hsa05160	0.37264763
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.36854966
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36728563
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.35217114
86	Fatty acid elongation_Homo sapiens_hsa00062	0.35188095
87	Pancreatic cancer_Homo sapiens_hsa05212	0.33374062
88	Long-term depression_Homo sapiens_hsa04730	0.32898600
89	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.32609173
90	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.32187497
91	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30958555
92	Proteasome_Homo sapiens_hsa03050	0.30423770
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.30085519
94	Small cell lung cancer_Homo sapiens_hsa05222	0.30005791
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.29982956
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.29535475
97	Glioma_Homo sapiens_hsa05214	0.29361844
98	GnRH signaling pathway_Homo sapiens_hsa04912	0.28811117
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27951342
100	Toxoplasmosis_Homo sapiens_hsa05145	0.26483007

EIF5A2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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