ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	limb bud formation (GO:0060174)	4.72545031
2	behavioral response to nicotine (GO:0035095)	4.70400026
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.11838059
4	somite development (GO:0061053)	3.92050675
5	neural tube formation (GO:0001841)	3.85287698
6	ATP synthesis coupled proton transport (GO:0015986)	3.82447504
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.82447504
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.79558048
9	protein complex biogenesis (GO:0070271)	3.65629833
10	regulation of hexokinase activity (GO:1903299)	3.60261828
11	regulation of glucokinase activity (GO:0033131)	3.60261828
12	response to pheromone (GO:0019236)	3.53283267
13	positive regulation of gastrulation (GO:2000543)	3.51203653
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.48575612
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45716050
16	NADH dehydrogenase complex assembly (GO:0010257)	3.45716050
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45716050
18	DNA deamination (GO:0045006)	3.45071405
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.43800997
20	platelet dense granule organization (GO:0060155)	3.40118788
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38966802
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.34838121
23	adaptation of signaling pathway (GO:0023058)	3.26522940
24	protein-cofactor linkage (GO:0018065)	3.25915071
25	kidney morphogenesis (GO:0060993)	3.25850075
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24204514
27	respiratory chain complex IV assembly (GO:0008535)	3.20160484
28	DNA damage response, detection of DNA damage (GO:0042769)	3.18968309
29	dopamine transport (GO:0015872)	3.18846450
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.17785455
31	transmission of nerve impulse (GO:0019226)	3.14960041
32	sequestering of actin monomers (GO:0042989)	3.13273690
33	hindbrain development (GO:0030902)	3.11244639
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09574674
35	cornea development in camera-type eye (GO:0061303)	3.04839044
36	fucose catabolic process (GO:0019317)	2.97656082
37	L-fucose metabolic process (GO:0042354)	2.97656082
38	L-fucose catabolic process (GO:0042355)	2.97656082
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97140879
40	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.95803164
41	epithelial cilium movement (GO:0003351)	2.94763695
42	retinal ganglion cell axon guidance (GO:0031290)	2.93668177
43	intraciliary transport (GO:0042073)	2.93584807
44	protein polyglutamylation (GO:0018095)	2.89707522
45	nucleobase catabolic process (GO:0046113)	2.87877603
46	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.86698845
47	electron transport chain (GO:0022900)	2.84967797
48	chaperone-mediated protein transport (GO:0072321)	2.84641171
49	lens fiber cell development (GO:0070307)	2.84581406
50	cytochrome complex assembly (GO:0017004)	2.84152176
51	indolalkylamine metabolic process (GO:0006586)	2.84132684
52	cullin deneddylation (GO:0010388)	2.83715785
53	protein neddylation (GO:0045116)	2.83432807
54	respiratory electron transport chain (GO:0022904)	2.80921468
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.79982703
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.79982703
57	somite rostral/caudal axis specification (GO:0032525)	2.78757122
58	spinal cord motor neuron differentiation (GO:0021522)	2.76828729
59	replication fork processing (GO:0031297)	2.72428419
60	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.70841981
61	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.70217147
62	behavioral response to ethanol (GO:0048149)	2.69057728
63	translational termination (GO:0006415)	2.67333088
64	viral transcription (GO:0019083)	2.63922167
65	meiotic chromosome segregation (GO:0045132)	2.63180295
66	regulation of cilium movement (GO:0003352)	2.60305423
67	mannosylation (GO:0097502)	2.59871916
68	regulation of mesoderm development (GO:2000380)	2.58441799
69	centriole replication (GO:0007099)	2.57948524
70	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56905670
71	protein prenylation (GO:0018342)	2.55549313
72	prenylation (GO:0097354)	2.55549313
73	short-term memory (GO:0007614)	2.54467359
74	protein deneddylation (GO:0000338)	2.54284789
75	cilium movement (GO:0003341)	2.51876879
76	indolalkylamine catabolic process (GO:0046218)	2.51589853
77	tryptophan catabolic process (GO:0006569)	2.51589853
78	indole-containing compound catabolic process (GO:0042436)	2.51589853
79	negative regulation of telomere maintenance (GO:0032205)	2.51236476
80	protein K6-linked ubiquitination (GO:0085020)	2.51194050
81	cilium morphogenesis (GO:0060271)	2.45746067
82	spinal cord development (GO:0021510)	2.45114906
83	synaptic transmission, cholinergic (GO:0007271)	2.44639536
84	rhodopsin mediated signaling pathway (GO:0016056)	2.43767582
85	proteasome assembly (GO:0043248)	2.43492681
86	axoneme assembly (GO:0035082)	2.43067111
87	detection of light stimulus involved in sensory perception (GO:0050962)	2.42779245
88	detection of light stimulus involved in visual perception (GO:0050908)	2.42779245
89	nucleobase biosynthetic process (GO:0046112)	2.42140516
90	kinetochore assembly (GO:0051382)	2.39875272
91	embryonic epithelial tube formation (GO:0001838)	2.39611583
92	nonmotile primary cilium assembly (GO:0035058)	2.38534209
93	ATP biosynthetic process (GO:0006754)	2.38193355
94	cotranslational protein targeting to membrane (GO:0006613)	2.36648265
95	sympathetic nervous system development (GO:0048485)	2.36207063
96	cell differentiation in spinal cord (GO:0021515)	2.35853674
97	kynurenine metabolic process (GO:0070189)	2.35456338
98	DNA double-strand break processing (GO:0000729)	2.35334558
99	recombinational repair (GO:0000725)	2.34666797
100	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.34166247

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73767262
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.98940739
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84365436
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80872279
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76904488
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76077233
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69715283
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67698123
9	VDR_22108803_ChIP-Seq_LS180_Human	2.47200374
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42099226
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42022810
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34804952
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33377037
14	EWS_26573619_Chip-Seq_HEK293_Human	2.15040928
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.12840446
16	FUS_26573619_Chip-Seq_HEK293_Human	2.11919150
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03644345
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03330278
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.99946518
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98429167
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96115901
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93340498
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.81834392
24	P300_19829295_ChIP-Seq_ESCs_Human	1.80416799
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.76389387
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74861353
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.71346812
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67900982
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63010694
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.62231160
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62119395
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60716286
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59087903
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54286407
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.53698084
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51285077
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51130927
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49720673
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47174242
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46956389
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45271010
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.41103472
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38785086
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.38479682
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.37605601
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.37269925
47	VDR_23849224_ChIP-Seq_CD4+_Human	1.35515846
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.33820149
49	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.33182882
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32318922
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32137292
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29846434
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29623608
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.29433980
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27783741
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27783741
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27640783
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27146126
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27146126
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25920901
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.25920901
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.23348195
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.21388848
64	NCOR_22424771_ChIP-Seq_293T_Human	1.19004535
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17444645
66	AR_25329375_ChIP-Seq_VCAP_Human	1.17356113
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16396720
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15997721
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15997721
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15359189
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14464731
72	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13359864
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13348005
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08891973
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07182175
76	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06538962
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.06513949
78	AR_20517297_ChIP-Seq_VCAP_Human	1.06262346
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04952663
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04240136
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.03682153
82	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03263739
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01848648
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01465202
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00854154
86	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00795031
87	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00135172
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99520730
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.97812155
90	TCF4_23295773_ChIP-Seq_U87_Human	0.97537348
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96611983
92	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96554339
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96155399
94	STAT3_23295773_ChIP-Seq_U87_Human	0.95879529
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95764412
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.95391847
97	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95391165
98	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.94329141
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94078118
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93410782

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.94592319
2	MP0003136_yellow_coat_color	2.90888479
3	MP0000372_irregular_coat_pigmentation	2.72650255
4	MP0003283_abnormal_digestive_organ	2.56426339
5	MP0003880_abnormal_central_pattern	2.47654718
6	MP0002736_abnormal_nociception_after	2.36333781
7	MP0000566_synostosis	2.35622744
8	MP0006292_abnormal_olfactory_placode	2.23543607
9	MP0001968_abnormal_touch/_nociception	2.18576668
10	MP0002234_abnormal_pharynx_morphology	2.12484806
11	MP0003195_calcinosis	2.05306697
12	MP0005551_abnormal_eye_electrophysiolog	2.00349131
13	MP0002638_abnormal_pupillary_reflex	1.98630893
14	MP0006072_abnormal_retinal_apoptosis	1.92615660
15	MP0002938_white_spotting	1.89408102
16	MP0004133_heterotaxia	1.87946465
17	MP0003011_delayed_dark_adaptation	1.81886387
18	MP0003878_abnormal_ear_physiology	1.81339554
19	MP0005377_hearing/vestibular/ear_phenot	1.81339554
20	MP0004147_increased_porphyrin_level	1.77786460
21	MP0003646_muscle_fatigue	1.76420826
22	MP0004885_abnormal_endolymph	1.75828477
23	MP0001485_abnormal_pinna_reflex	1.74246736
24	MP0002132_abnormal_respiratory_system	1.72763616
25	MP0005253_abnormal_eye_physiology	1.71058951
26	MP0000631_abnormal_neuroendocrine_gland	1.70485463
27	MP0001529_abnormal_vocalization	1.70151278
28	MP0004142_abnormal_muscle_tone	1.67502230
29	MP0006276_abnormal_autonomic_nervous	1.64775809
30	MP0008875_abnormal_xenobiotic_pharmacok	1.60103857
31	MP0008877_abnormal_DNA_methylation	1.58759739
32	MP0002653_abnormal_ependyma_morphology	1.57739887
33	MP0008995_early_reproductive_senescence	1.53739697
34	MP0005084_abnormal_gallbladder_morpholo	1.53734567
35	MP0000778_abnormal_nervous_system	1.52731855
36	MP0005646_abnormal_pituitary_gland	1.52314907
37	MP0002277_abnormal_respiratory_mucosa	1.51567778
38	MP0003119_abnormal_digestive_system	1.51549811
39	MP0009745_abnormal_behavioral_response	1.50918892
40	MP0001293_anophthalmia	1.47878595
41	MP0003890_abnormal_embryonic-extraembry	1.47593181
42	MP0004742_abnormal_vestibular_system	1.46286341
43	MP0002751_abnormal_autonomic_nervous	1.42983192
44	MP0002837_dystrophic_cardiac_calcinosis	1.42419714
45	MP0003718_maternal_effect	1.41179411
46	MP0008872_abnormal_physiological_respon	1.37662156
47	MP0001486_abnormal_startle_reflex	1.35089823
48	MP0001905_abnormal_dopamine_level	1.33506353
49	MP0002272_abnormal_nervous_system	1.33002497
50	MP0009379_abnormal_foot_pigmentation	1.32740893
51	MP0008789_abnormal_olfactory_epithelium	1.27071385
52	MP0002282_abnormal_trachea_morphology	1.21307276
53	MP0009046_muscle_twitch	1.20046442
54	MP0002557_abnormal_social/conspecific_i	1.16037981
55	MP0000647_abnormal_sebaceous_gland	1.12648361
56	MP0005195_abnormal_posterior_eye	1.12470059
57	MP0000427_abnormal_hair_cycle	1.10907065
58	MP0000026_abnormal_inner_ear	1.09593984
59	MP0002572_abnormal_emotion/affect_behav	1.08122044
60	MP0003938_abnormal_ear_development	1.08034456
61	MP0000049_abnormal_middle_ear	1.07127355
62	MP0002184_abnormal_innervation	1.04875450
63	MP0002163_abnormal_gland_morphology	1.04350519
64	MP0002752_abnormal_somatic_nervous	1.04039575
65	MP0002064_seizures	1.03702663
66	MP0002876_abnormal_thyroid_physiology	1.01978959
67	MP0003937_abnormal_limbs/digits/tail_de	1.01711289
68	MP0008058_abnormal_DNA_repair	1.00446659
69	MP0004145_abnormal_muscle_electrophysio	1.00382230
70	MP0002160_abnormal_reproductive_system	0.98761687
71	MP0002067_abnormal_sensory_capabilities	0.98594536
72	MP0002735_abnormal_chemical_nociception	0.98310745
73	MP0002928_abnormal_bile_duct	0.97604580
74	MP0000383_abnormal_hair_follicle	0.97514074
75	MP0004924_abnormal_behavior	0.96533022
76	MP0005386_behavior/neurological_phenoty	0.96533022
77	MP0001984_abnormal_olfaction	0.96195672
78	MP0009697_abnormal_copulation	0.94333676
79	MP0001986_abnormal_taste_sensitivity	0.93308163
80	MP0003121_genomic_imprinting	0.92621624
81	MP0003787_abnormal_imprinting	0.92371877
82	MP0003137_abnormal_impulse_conducting	0.92317197
83	MP0005391_vision/eye_phenotype	0.92044440
84	MP0005645_abnormal_hypothalamus_physiol	0.90120609
85	MP0005499_abnormal_olfactory_system	0.86947680
86	MP0005394_taste/olfaction_phenotype	0.86947680
87	MP0005171_absent_coat_pigmentation	0.85602501
88	MP0001963_abnormal_hearing_physiology	0.85126361
89	MP0001764_abnormal_homeostasis	0.84165694
90	MP0003635_abnormal_synaptic_transmissio	0.83294871
91	MP0005389_reproductive_system_phenotype	0.82789325
92	MP0002210_abnormal_sex_determination	0.82550747
93	MP0001324_abnormal_eye_pigmentation	0.81864468
94	MP0005379_endocrine/exocrine_gland_phen	0.81679697
95	MP0005187_abnormal_penis_morphology	0.80362833
96	MP0001501_abnormal_sleep_pattern	0.77112107
97	MP0002733_abnormal_thermal_nociception	0.76780661
98	MP0000955_abnormal_spinal_cord	0.76587201
99	MP0001286_abnormal_eye_development	0.76447924
100	MP0003122_maternal_imprinting	0.76073708

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.03830345
2	True hermaphroditism (HP:0010459)	3.90623365
3	Pancreatic fibrosis (HP:0100732)	3.78491597
4	Abnormality of midbrain morphology (HP:0002418)	3.61302281
5	Molar tooth sign on MRI (HP:0002419)	3.61302281
6	Congenital stationary night blindness (HP:0007642)	3.32530721
7	Nephronophthisis (HP:0000090)	3.07518177
8	3-Methylglutaconic aciduria (HP:0003535)	3.04524423
9	Acute necrotizing encephalopathy (HP:0006965)	3.02222209
10	Type II lissencephaly (HP:0007260)	3.01990336
11	Pendular nystagmus (HP:0012043)	2.95074960
12	Mitochondrial inheritance (HP:0001427)	2.71306022
13	Acute encephalopathy (HP:0006846)	2.66297183
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65726665
15	Concave nail (HP:0001598)	2.65441586
16	Progressive macrocephaly (HP:0004481)	2.65326002
17	Attenuation of retinal blood vessels (HP:0007843)	2.63797238
18	Abnormality of the labia minora (HP:0012880)	2.58329090
19	Abnormality of the renal medulla (HP:0100957)	2.55930481
20	Abolished electroretinogram (ERG) (HP:0000550)	2.52580837
21	Chronic hepatic failure (HP:0100626)	2.51737170
22	Increased CSF lactate (HP:0002490)	2.50185770
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.46613930
24	Abnormality of the renal cortex (HP:0011035)	2.45206856
25	Sclerocornea (HP:0000647)	2.44419058
26	Hyperglycinemia (HP:0002154)	2.40499486
27	Abnormal number of erythroid precursors (HP:0012131)	2.39973876
28	Anencephaly (HP:0002323)	2.38343730
29	Cerebellar dysplasia (HP:0007033)	2.37035794
30	Cystic liver disease (HP:0006706)	2.34626514
31	Congenital, generalized hypertrichosis (HP:0004540)	2.33953085
32	Optic disc pallor (HP:0000543)	2.30253442
33	Bilateral microphthalmos (HP:0007633)	2.30219775
34	Increased hepatocellular lipid droplets (HP:0006565)	2.29850071
35	Methylmalonic acidemia (HP:0002912)	2.27726612
36	Hepatocellular necrosis (HP:0001404)	2.27704765
37	Occipital encephalocele (HP:0002085)	2.25337736
38	Lissencephaly (HP:0001339)	2.24616653
39	Patellar aplasia (HP:0006443)	2.24393282
40	Hepatic necrosis (HP:0002605)	2.24092522
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.23313761
42	Hypoplasia of the pons (HP:0012110)	2.20604719
43	Abnormality of the pons (HP:0007361)	2.18672688
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17693641
45	Abnormal ciliary motility (HP:0012262)	2.16440237
46	Medial flaring of the eyebrow (HP:0010747)	2.15886007
47	Postaxial foot polydactyly (HP:0001830)	2.15073123
48	Keratoconus (HP:0000563)	2.12862347
49	Increased corneal curvature (HP:0100692)	2.12862347
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.11256869
51	Lipid accumulation in hepatocytes (HP:0006561)	2.10594724
52	Optic nerve hypoplasia (HP:0000609)	2.09443992
53	Inability to walk (HP:0002540)	2.06562081
54	Retinal dysplasia (HP:0007973)	2.06390131
55	Septo-optic dysplasia (HP:0100842)	2.06260778
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05607750
57	Preaxial hand polydactyly (HP:0001177)	2.05567546
58	Abnormality of cells of the erythroid lineage (HP:0012130)	2.03578113
59	Colon cancer (HP:0003003)	2.03386633
60	Male pseudohermaphroditism (HP:0000037)	2.02077185
61	Birth length less than 3rd percentile (HP:0003561)	2.01280571
62	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96290833
63	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95902753
64	Abnormal biliary tract physiology (HP:0012439)	1.95541030
65	Bile duct proliferation (HP:0001408)	1.95541030
66	Triphalangeal thumb (HP:0001199)	1.92021217
67	Anophthalmia (HP:0000528)	1.87843590
68	Renal cortical cysts (HP:0000803)	1.87188762
69	Reticulocytopenia (HP:0001896)	1.86934067
70	Gait imbalance (HP:0002141)	1.86535281
71	Methylmalonic aciduria (HP:0012120)	1.85065778
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84508348
73	Abnormality of alanine metabolism (HP:0010916)	1.84508348
74	Hyperalaninemia (HP:0003348)	1.84508348
75	Decreased central vision (HP:0007663)	1.84466117
76	Dandy-Walker malformation (HP:0001305)	1.84113822
77	Bony spicule pigmentary retinopathy (HP:0007737)	1.83937023
78	Polydipsia (HP:0001959)	1.83858187
79	Abnormal drinking behavior (HP:0030082)	1.83858187
80	Tubular atrophy (HP:0000092)	1.83007812
81	Pachygyria (HP:0001302)	1.81900470
82	Macrocytic anemia (HP:0001972)	1.81662913
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81535273
84	Postaxial hand polydactyly (HP:0001162)	1.81131652
85	Thyroid-stimulating hormone excess (HP:0002925)	1.80354708
86	Furrowed tongue (HP:0000221)	1.79123937
87	Oligodactyly (hands) (HP:0001180)	1.78984506
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.78288857
89	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78288857
90	Hyperventilation (HP:0002883)	1.77112432
91	Congenital primary aphakia (HP:0007707)	1.76116858
92	Congenital hepatic fibrosis (HP:0002612)	1.74580853
93	Abnormality of the ileum (HP:0001549)	1.74150010
94	Meckel diverticulum (HP:0002245)	1.74080195
95	Cerebral edema (HP:0002181)	1.73725468
96	Short tibia (HP:0005736)	1.73472649
97	Genital tract atresia (HP:0001827)	1.73132537
98	Focal motor seizures (HP:0011153)	1.72513671
99	Chorioretinal atrophy (HP:0000533)	1.71939882
100	Renal Fanconi syndrome (HP:0001994)	1.70448924

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	3.69451991
2	FRK	3.26900795
3	MAP4K2	3.22859629
4	WNK3	2.92012425
5	NUAK1	2.62854589
6	ADRBK2	2.41274506
7	PNCK	2.20276571
8	ZAK	2.15365745
9	GRK1	2.07881750
10	VRK2	2.07235717
11	MAPK13	2.02504833
12	BMPR1B	1.92549608
13	PINK1	1.86104821
14	MAP3K4	1.82156290
15	WEE1	1.81867983
16	MARK1	1.78070103
17	CASK	1.69714658
18	DYRK2	1.67695437
19	EPHA4	1.65352538
20	VRK1	1.61915812
21	TNIK	1.60579828
22	TXK	1.58916868
23	TLK1	1.44162505
24	WNK4	1.42063616
25	MAP2K7	1.41742743
26	OXSR1	1.36942174
27	BUB1	1.28324797
28	EPHB2	1.26862767
29	TRIM28	1.26851075
30	PLK3	1.19269366
31	PLK2	1.19169822
32	STK39	1.16716788
33	ITK	1.14539989
34	TAF1	1.14251819
35	BRSK2	1.08177879
36	FGFR2	1.06554185
37	PASK	1.05583266
38	BCKDK	1.05396676
39	TAOK3	1.01912084
40	PRKCG	0.99994438
41	CDK19	0.99477317
42	TGFBR1	0.96140486
43	MKNK2	0.92076352
44	ADRBK1	0.89590954
45	PLK4	0.89029772
46	PAK3	0.87475704
47	ACVR1B	0.84533698
48	CDC7	0.84406072
49	SRPK1	0.81581499
50	NTRK2	0.81489826
51	MKNK1	0.81229351
52	NME1	0.80687172
53	MUSK	0.79415498
54	CSNK1G2	0.76696857
55	PKN1	0.76509498
56	ERBB3	0.76394837
57	DYRK3	0.75962846
58	RPS6KA5	0.75927447
59	MINK1	0.72651093
60	PTK2B	0.72245873
61	BCR	0.69882253
62	MAPKAPK5	0.69811156
63	CSNK1G3	0.67535295
64	PLK1	0.65347570
65	TIE1	0.65153245
66	EIF2AK1	0.64398370
67	NEK1	0.63933785
68	PRKCE	0.62358672
69	TSSK6	0.61347744
70	MST4	0.60274205
71	CHEK2	0.59442919
72	MAPK15	0.57040460
73	CSNK1G1	0.56607745
74	PHKG1	0.56131624
75	PHKG2	0.56131624
76	CSNK1A1L	0.55540037
77	KDR	0.54757668
78	CSNK1A1	0.53403706
79	NTRK3	0.50590028
80	PIK3CA	0.50377446
81	CDK3	0.48582406
82	PRKCZ	0.47181278
83	GRK7	0.46886530
84	EIF2AK3	0.46734041
85	PRKACA	0.46532008
86	CAMKK2	0.45731853
87	GRK5	0.43802104
88	NEK2	0.43312128
89	CAMK2A	0.42847394
90	PRKCQ	0.42748748
91	STK11	0.42458964
92	SIK2	0.42162635
93	DYRK1A	0.39715993
94	MARK3	0.38760935
95	CSNK2A1	0.36953264
96	AURKB	0.36861299
97	STK3	0.36302443
98	MAP2K6	0.36171141
99	DAPK2	0.36088758
100	TEC	0.36070623

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.50244801
2	Ribosome_Homo sapiens_hsa03010	3.11856449
3	Parkinsons disease_Homo sapiens_hsa05012	2.81469449
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.67641381
5	Phototransduction_Homo sapiens_hsa04744	2.45422771
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.35504579
7	Protein export_Homo sapiens_hsa03060	2.32894247
8	Proteasome_Homo sapiens_hsa03050	2.09242365
9	Butanoate metabolism_Homo sapiens_hsa00650	2.06030134
10	RNA polymerase_Homo sapiens_hsa03020	2.03638215
11	Huntingtons disease_Homo sapiens_hsa05016	2.00903518
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98535396
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96714769
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93652313
15	Homologous recombination_Homo sapiens_hsa03440	1.91048143
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88132771
17	Nicotine addiction_Homo sapiens_hsa05033	1.84994105
18	Caffeine metabolism_Homo sapiens_hsa00232	1.83001736
19	Alzheimers disease_Homo sapiens_hsa05010	1.82949703
20	Basal transcription factors_Homo sapiens_hsa03022	1.72950972
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72349552
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70216081
23	RNA degradation_Homo sapiens_hsa03018	1.68545247
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67857656
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.61127283
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59322616
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59177113
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.54072179
29	One carbon pool by folate_Homo sapiens_hsa00670	1.51414125
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43589064
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40332611
32	Propanoate metabolism_Homo sapiens_hsa00640	1.37590891
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.36324824
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35388851
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.24086742
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15862308
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15393742
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.11926105
39	Spliceosome_Homo sapiens_hsa03040	1.11856384
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09825064
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04751185
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01348819
43	Taste transduction_Homo sapiens_hsa04742	0.99278007
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99190918
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.98750372
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98748894
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98214109
48	Peroxisome_Homo sapiens_hsa04146	0.97344574
49	Olfactory transduction_Homo sapiens_hsa04740	0.95131413
50	Purine metabolism_Homo sapiens_hsa00230	0.93409522
51	Retinol metabolism_Homo sapiens_hsa00830	0.92336181
52	Mismatch repair_Homo sapiens_hsa03430	0.91521259
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89015963
54	Base excision repair_Homo sapiens_hsa03410	0.86629952
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.82778973
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82077511
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81614105
58	Regulation of autophagy_Homo sapiens_hsa04140	0.80815197
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.79753588
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75372550
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.75094986
62	RNA transport_Homo sapiens_hsa03013	0.74807972
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.73070238
64	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72893846
65	Morphine addiction_Homo sapiens_hsa05032	0.72573534
66	Metabolic pathways_Homo sapiens_hsa01100	0.71528842
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70628568
68	DNA replication_Homo sapiens_hsa03030	0.68564189
69	GABAergic synapse_Homo sapiens_hsa04727	0.68439848
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.66434323
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.65955145
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.65142871
73	Sulfur metabolism_Homo sapiens_hsa00920	0.61561248
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56979527
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55557191
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54041056
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53804809
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52219502
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51693764
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.51687313
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51223494
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.49311728
83	Serotonergic synapse_Homo sapiens_hsa04726	0.49007532
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46407085
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45731120
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45586879
87	Glutathione metabolism_Homo sapiens_hsa00480	0.43704942
88	Fatty acid elongation_Homo sapiens_hsa00062	0.43231456
89	Mineral absorption_Homo sapiens_hsa04978	0.43153082
90	Folate biosynthesis_Homo sapiens_hsa00790	0.42252483
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.41910890
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.41366565
93	ABC transporters_Homo sapiens_hsa02010	0.37763582
94	Sulfur relay system_Homo sapiens_hsa04122	0.35552848
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35006925
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.30737141
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.30652398
98	Circadian entrainment_Homo sapiens_hsa04713	0.30244681
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30223123
100	Fatty acid degradation_Homo sapiens_hsa00071	0.30210298

EIF5AP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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