EIF5AP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.69812133
2regulation of hydrogen peroxide metabolic process (GO:0010310)4.76766417
3cytidine deamination (GO:0009972)4.70560380
4cytidine metabolic process (GO:0046087)4.70560380
5cytidine catabolic process (GO:0006216)4.70560380
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.57886060
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.55539579
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.49379392
9tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.49379392
10rRNA modification (GO:0000154)4.44492159
11rRNA methylation (GO:0031167)4.41847359
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.36061698
13ATP synthesis coupled proton transport (GO:0015986)4.36061698
14actin nucleation (GO:0045010)4.02288275
15pyrimidine ribonucleoside catabolic process (GO:0046133)3.90128690
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86245623
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.86245623
18NADH dehydrogenase complex assembly (GO:0010257)3.86245623
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.83947149
20regulation of respiratory burst (GO:0060263)3.81281801
21purine deoxyribonucleotide catabolic process (GO:0009155)3.77154588
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67301140
23protein neddylation (GO:0045116)3.62370981
24protein complex biogenesis (GO:0070271)3.59756377
25respiratory electron transport chain (GO:0022904)3.56980694
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53926160
27platelet dense granule organization (GO:0060155)3.52637651
28electron transport chain (GO:0022900)3.50906581
29proteasome assembly (GO:0043248)3.49240986
30protein-cofactor linkage (GO:0018065)3.43015774
31deoxyribose phosphate catabolic process (GO:0046386)3.42807836
32regulation of cellular amino acid metabolic process (GO:0006521)3.42067129
33regulation of hypersensitivity (GO:0002883)3.37865399
34positive regulation of calcium-mediated signaling (GO:0050850)3.35343641
35mitochondrial respiratory chain complex assembly (GO:0033108)3.35240599
36interferon-gamma production (GO:0032609)3.33791872
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.28796196
38deoxyribonucleotide catabolic process (GO:0009264)3.28476636
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25886123
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22749822
41negative T cell selection (GO:0043383)3.22077804
42ribonucleoprotein complex disassembly (GO:0032988)3.21216089
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17948226
44adenosine metabolic process (GO:0046085)3.17644114
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16692510
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16204745
47purine nucleotide salvage (GO:0032261)3.13632895
48immunoglobulin mediated immune response (GO:0016064)3.13107239
49viral mRNA export from host cell nucleus (GO:0046784)3.07473756
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07065762
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07065762
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07065762
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05742966
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05742966
55antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04553075
56regulation of DNA endoreduplication (GO:0032875)3.02773486
57behavioral response to nicotine (GO:0035095)2.98905490
58deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.97146661
59signal transduction involved in DNA damage checkpoint (GO:0072422)2.94470520
60signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94470520
61negative regulation of B cell apoptotic process (GO:0002903)2.94435963
62positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.93303292
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92312733
64signal transduction involved in cell cycle checkpoint (GO:0072395)2.90686332
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88748019
66negative regulation of T cell apoptotic process (GO:0070233)2.87176360
67positive regulation of interleukin-8 secretion (GO:2000484)2.87155101
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86414946
69positive regulation of interleukin-17 production (GO:0032740)2.84929302
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84524280
71negative regulation by host of viral transcription (GO:0043922)2.82648798
72sequestering of actin monomers (GO:0042989)2.82168227
73regulation of T cell tolerance induction (GO:0002664)2.81641529
74mast cell activation (GO:0045576)2.78191061
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78108226
76T cell migration (GO:0072678)2.76669584
77B cell mediated immunity (GO:0019724)2.76600062
78GPI anchor biosynthetic process (GO:0006506)2.75981908
79respiratory chain complex IV assembly (GO:0008535)2.74966921
80T cell costimulation (GO:0031295)2.73197145
81positive regulation of tolerance induction (GO:0002645)2.73087169
82iron-sulfur cluster assembly (GO:0016226)2.72375221
83metallo-sulfur cluster assembly (GO:0031163)2.72375221
84T cell receptor signaling pathway (GO:0050852)2.70609436
85regulation of interleukin-8 secretion (GO:2000482)2.70282261
86lymphocyte costimulation (GO:0031294)2.69973875
87positive T cell selection (GO:0043368)2.69906408
88regulation of B cell receptor signaling pathway (GO:0050855)2.68690729
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68096816
90negative regulation of ligase activity (GO:0051352)2.68096816
91negative regulation of lymphocyte apoptotic process (GO:0070229)2.68032580
92positive thymic T cell selection (GO:0045059)2.64300587
93hydrogen ion transmembrane transport (GO:1902600)2.61757376
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61371048
95ribosomal small subunit assembly (GO:0000028)2.60606948
96antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.60110027
97base-excision repair, AP site formation (GO:0006285)2.59606052
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57052776
99mast cell degranulation (GO:0043303)2.56496526
100mast cell activation involved in immune response (GO:0002279)2.56496526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.15472460
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.91943676
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.85565694
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.66152513
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54910526
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.94100813
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89464439
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75102701
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.73027694
10VDR_23849224_ChIP-Seq_CD4+_Human2.38932895
11ZNF274_21170338_ChIP-Seq_K562_Hela2.38549321
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38050984
13IGF1R_20145208_ChIP-Seq_DFB_Human2.32137926
14VDR_22108803_ChIP-Seq_LS180_Human2.31700937
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.28441187
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25896194
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22250619
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17553609
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.17483786
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14272143
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.11479719
22FOXP3_21729870_ChIP-Seq_TREG_Human2.02780013
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87099661
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83602348
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.82281575
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80455244
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78398941
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74874725
29IRF1_19129219_ChIP-ChIP_H3396_Human1.72417382
30MYB_26560356_Chip-Seq_TH2_Human1.70704465
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68868796
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67202528
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63113769
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61513243
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52911500
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52025464
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.51332395
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46570629
39EZH2_22144423_ChIP-Seq_EOC_Human1.46549999
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45595344
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44986353
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44561756
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39406927
44GATA3_27048872_Chip-Seq_THYMUS_Human1.36904786
45NANOG_20526341_ChIP-Seq_ESCs_Human1.34802372
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32629634
47BCL6_27268052_Chip-Seq_Bcells_Human1.32242708
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31178622
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29926212
50AR_20517297_ChIP-Seq_VCAP_Human1.28144029
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27973135
52SPI1_23547873_ChIP-Seq_NB4_Human1.27405068
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.27353032
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27353032
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25646157
56TAF2_19829295_ChIP-Seq_ESCs_Human1.25347247
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24287570
58TP53_22573176_ChIP-Seq_HFKS_Human1.23238808
59GATA3_26560356_Chip-Seq_TH2_Human1.23081940
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19666395
61GABP_19822575_ChIP-Seq_HepG2_Human1.19229615
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18984522
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18134924
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17086928
65CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16100897
66ELK1_19687146_ChIP-ChIP_HELA_Human1.13978126
67NCOR_22424771_ChIP-Seq_293T_Human1.12918682
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10957390
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10768457
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09380217
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08886215
72SPI1_20517297_ChIP-Seq_HL60_Human1.08169077
73NANOG_19829295_ChIP-Seq_ESCs_Human1.07689767
74SOX2_19829295_ChIP-Seq_ESCs_Human1.07689767
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05481756
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05178340
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.05160631
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04820249
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03803363
80P300_27268052_Chip-Seq_Bcells_Human1.02516719
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00555359
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00375710
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99814778
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98488045
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98408840
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98360536
87MYC_18940864_ChIP-ChIP_HL60_Human0.96763586
88MYC_19829295_ChIP-Seq_ESCs_Human0.95948040
89MYB_26560356_Chip-Seq_TH1_Human0.94888610
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.94657064
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94591846
92ERA_21632823_ChIP-Seq_H3396_Human0.91131412
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90908635
94SCL_19346495_ChIP-Seq_HPC-7_Human0.90477815
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89295722
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88922118
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88452461
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.88219144
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87567838
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86585234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.22790530
2MP0001835_abnormal_antigen_presentation3.81783692
3MP0009785_altered_susceptibility_to2.76652151
4MP0003806_abnormal_nucleotide_metabolis2.60117657
5MP0002166_altered_tumor_susceptibility2.53210218
6MP0001986_abnormal_taste_sensitivity2.43506296
7MP0006072_abnormal_retinal_apoptosis2.38650402
8MP0003866_abnormal_defecation2.29038547
9MP0002163_abnormal_gland_morphology2.25478259
10MP0000372_irregular_coat_pigmentation2.11615445
11MP0004147_increased_porphyrin_level2.09621195
12MP0006276_abnormal_autonomic_nervous2.09239357
13MP0003646_muscle_fatigue2.01589742
14MP0005000_abnormal_immune_tolerance1.96255719
15MP0001800_abnormal_humoral_immune1.96140167
16MP0005360_urolithiasis1.90400583
17MP0002006_tumorigenesis1.87591586
18MP0002148_abnormal_hypersensitivity_rea1.86378119
19MP0008872_abnormal_physiological_respon1.84593489
20MP0002723_abnormal_immune_serum1.80509637
21MP0001919_abnormal_reproductive_system1.78922860
22MP0005387_immune_system_phenotype1.78652697
23MP0001790_abnormal_immune_system1.78652697
24MP0003724_increased_susceptibility_to1.78554113
25MP0009697_abnormal_copulation1.70156821
26MP0003763_abnormal_thymus_physiology1.69930928
27MP0004145_abnormal_muscle_electrophysio1.69779093
28MP0002420_abnormal_adaptive_immunity1.69379190
29MP0005025_abnormal_response_to1.68772002
30MP0001819_abnormal_immune_cell1.65934822
31MP0009333_abnormal_splenocyte_physiolog1.65146550
32MP0008875_abnormal_xenobiotic_pharmacok1.63741556
33MP0002452_abnormal_antigen_presenting1.60653094
34MP0005646_abnormal_pituitary_gland1.57314175
35MP0006036_abnormal_mitochondrial_physio1.56658555
36MP0005647_abnormal_sex_gland1.56402571
37MP0002102_abnormal_ear_morphology1.55549517
38MP0009764_decreased_sensitivity_to1.53750331
39MP0005645_abnormal_hypothalamus_physiol1.53364317
40MP0005389_reproductive_system_phenotype1.49739154
41MP0001905_abnormal_dopamine_level1.48389465
42MP0002837_dystrophic_cardiac_calcinosis1.45067385
43MP0001968_abnormal_touch/_nociception1.40890745
44MP0001661_extended_life_span1.40067276
45MP0006082_CNS_inflammation1.30986184
46MP0003252_abnormal_bile_duct1.30453744
47MP0005084_abnormal_gallbladder_morpholo1.30344238
48MP0002933_joint_inflammation1.27972668
49MP0005075_abnormal_melanosome_morpholog1.24979891
50MP0005253_abnormal_eye_physiology1.24840765
51MP0005410_abnormal_fertilization1.22892147
52MP0010155_abnormal_intestine_physiology1.22480343
53MP0000716_abnormal_immune_system1.22194914
54MP0002398_abnormal_bone_marrow1.21684992
55MP0010386_abnormal_urinary_bladder1.21025586
56MP0005379_endocrine/exocrine_gland_phen1.18835021
57MP0001873_stomach_inflammation1.17967516
58MP0005636_abnormal_mineral_homeostasis1.16331600
59MP0005551_abnormal_eye_electrophysiolog1.15047424
60MP0002419_abnormal_innate_immunity1.14887363
61MP0000685_abnormal_immune_system1.14348243
62MP0003787_abnormal_imprinting1.13864786
63MP0001845_abnormal_inflammatory_respons1.11859712
64MP0002735_abnormal_chemical_nociception1.09134883
65MP0003195_calcinosis1.08281012
66MP0003878_abnormal_ear_physiology1.08245475
67MP0005377_hearing/vestibular/ear_phenot1.08245475
68MP0003075_altered_response_to1.07731003
69MP0002009_preneoplasia1.05533588
70MP0008469_abnormal_protein_level1.04931412
71MP0002160_abnormal_reproductive_system1.04901941
72MP0009379_abnormal_foot_pigmentation1.02391455
73MP0001756_abnormal_urination1.00336425
74MP0000689_abnormal_spleen_morphology0.99652927
75MP0001764_abnormal_homeostasis0.99214587
76MP0003436_decreased_susceptibility_to0.98862688
77MP0002429_abnormal_blood_cell0.98815913
78MP0001765_abnormal_ion_homeostasis0.98506338
79MP0003186_abnormal_redox_activity0.97125066
80MP0001727_abnormal_embryo_implantation0.95313969
81MP0009763_increased_sensitivity_to0.94239075
82MP0005464_abnormal_platelet_physiology0.93604023
83MP0004142_abnormal_muscle_tone0.92451103
84MP0002736_abnormal_nociception_after0.92298813
85MP0002733_abnormal_thermal_nociception0.90085136
86MP0002722_abnormal_immune_system0.87623984
87MP0003880_abnormal_central_pattern0.87248373
88MP0008058_abnormal_DNA_repair0.83832172
89MP0005165_increased_susceptibility_to0.81985528
90MP0003315_abnormal_perineum_morphology0.81949892
91MP0003786_premature_aging0.81749821
92MP0001542_abnormal_bone_strength0.79315370
93MP0006035_abnormal_mitochondrial_morpho0.77892424
94MP0003718_maternal_effect0.77032202
95MP0009643_abnormal_urine_homeostasis0.75776684
96MP0005166_decreased_susceptibility_to0.73551443
97MP0000639_abnormal_adrenal_gland0.72501139
98MP0008995_early_reproductive_senescence0.72497504
99MP0005332_abnormal_amino_acid0.71831417
100MP0002019_abnormal_tumor_incidence0.71640176

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.53164645
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.63358670
3Abnormality of alanine metabolism (HP:0010916)4.63358670
4Hyperalaninemia (HP:0003348)4.63358670
5Chronic sinusitis (HP:0011109)4.36730532
6Hepatocellular necrosis (HP:0001404)4.00660381
7Elevated erythrocyte sedimentation rate (HP:0003565)3.98308662
8Abnormal mitochondria in muscle tissue (HP:0008316)3.87765825
9Mitochondrial inheritance (HP:0001427)3.87245044
10Acute necrotizing encephalopathy (HP:0006965)3.70659593
11Hepatic necrosis (HP:0002605)3.49512343
12Chronic otitis media (HP:0000389)3.39385977
13Abnormal respiratory motile cilium morphology (HP:0005938)3.33998305
14Abnormal respiratory epithelium morphology (HP:0012253)3.33998305
15Increased CSF lactate (HP:0002490)3.28324442
16Increased intramyocellular lipid droplets (HP:0012240)3.17817511
17Acute encephalopathy (HP:0006846)3.06315108
18Increased muscle lipid content (HP:0009058)3.01703853
19Severe combined immunodeficiency (HP:0004430)3.01066346
20Hypoproteinemia (HP:0003075)2.96382986
21Congenital stationary night blindness (HP:0007642)2.90760575
22Progressive macrocephaly (HP:0004481)2.85889474
23Renal Fanconi syndrome (HP:0001994)2.84103573
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.76957349
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.76957349
26Agammaglobulinemia (HP:0004432)2.75406354
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.72167202
28Lipid accumulation in hepatocytes (HP:0006561)2.68184002
293-Methylglutaconic aciduria (HP:0003535)2.68045017
30Cerebral edema (HP:0002181)2.66217985
31Increased serum lactate (HP:0002151)2.60422857
32Lactic acidosis (HP:0003128)2.56759596
33Type I transferrin isoform profile (HP:0003642)2.53779568
34Polydipsia (HP:0001959)2.52371464
35Abnormal drinking behavior (HP:0030082)2.52371464
36Increased hepatocellular lipid droplets (HP:0006565)2.46112582
37Constricted visual fields (HP:0001133)2.44244432
38Renal cortical cysts (HP:0000803)2.42417109
39Decreased circulating renin level (HP:0003351)2.41077232
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39851727
41Microretrognathia (HP:0000308)2.34797138
42IgG deficiency (HP:0004315)2.31916044
43Panhypogammaglobulinemia (HP:0003139)2.31681211
44Petechiae (HP:0000967)2.30906198
45T lymphocytopenia (HP:0005403)2.30309777
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28738184
47Abolished electroretinogram (ERG) (HP:0000550)2.26468412
48Radial bowing (HP:0002986)2.24534487
49Leukodystrophy (HP:0002415)2.24265840
50Exertional dyspnea (HP:0002875)2.24177730
51Type 2 muscle fiber atrophy (HP:0003554)2.22309180
52Abnormality of serum amino acid levels (HP:0003112)2.19060785
53Cerebral palsy (HP:0100021)2.17270830
54Optic disc pallor (HP:0000543)2.16121432
55Respiratory failure (HP:0002878)2.15529235
56Abnormality of the prostate (HP:0008775)2.15178869
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.14647951
58Short tibia (HP:0005736)2.13068341
59Combined immunodeficiency (HP:0005387)2.12178390
60Abnormality of T cell number (HP:0011839)2.11807768
61Abnormality of midbrain morphology (HP:0002418)2.04873147
62Molar tooth sign on MRI (HP:0002419)2.04873147
63Abnormality of eosinophils (HP:0001879)2.03029884
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.01270341
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00445497
66Generalized aminoaciduria (HP:0002909)2.00056440
67Dicarboxylic aciduria (HP:0003215)1.99201461
68Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99201461
69Amyotrophic lateral sclerosis (HP:0007354)1.98198241
70Abnormality of the heme biosynthetic pathway (HP:0010472)1.97848226
71Autoimmune hemolytic anemia (HP:0001890)1.97762520
72Muscle fiber atrophy (HP:0100295)1.97596091
73Thyroiditis (HP:0100646)1.95811432
74Adrenal hypoplasia (HP:0000835)1.94924672
75Recurrent cutaneous fungal infections (HP:0011370)1.93777227
76Chronic mucocutaneous candidiasis (HP:0002728)1.93777227
77Polyuria (HP:0000103)1.93489512
78Exercise intolerance (HP:0003546)1.93477982
79Congenital, generalized hypertrichosis (HP:0004540)1.92075937
80Nephronophthisis (HP:0000090)1.90002198
81Reduced antithrombin III activity (HP:0001976)1.87701710
82Chronic diarrhea (HP:0002028)1.84055577
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83849457
84Abnormal protein N-linked glycosylation (HP:0012347)1.83849457
85Abnormal protein glycosylation (HP:0012346)1.83849457
86Abnormal glycosylation (HP:0012345)1.83849457
87Abnormal ciliary motility (HP:0012262)1.82542464
88Abnormal respiratory motile cilium physiology (HP:0012261)1.81989383
89Pancytopenia (HP:0001876)1.81217625
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.79646159
91Absent/shortened dynein arms (HP:0200106)1.79646159
92CNS demyelination (HP:0007305)1.79213772
93Porencephaly (HP:0002132)1.79018638
94Pancreatic cysts (HP:0001737)1.78181661
95Abnormality of renal resorption (HP:0011038)1.77628737
96Encephalitis (HP:0002383)1.77121711
97Submucous cleft hard palate (HP:0000176)1.76709229
98Supernumerary spleens (HP:0009799)1.75952768
99Clumsiness (HP:0002312)1.75504089
100Meningitis (HP:0001287)1.75264590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.97898674
2KDR4.62659272
3MAP4K23.64530006
4TLK13.14521482
5BCKDK2.94601757
6ZAK2.72523654
7MAP3K122.41588854
8BMPR22.27812475
9MAP3K112.13668511
10SCYL22.05443316
11MAP4K12.02923525
12BLK2.00427526
13TXK1.77025053
14MATK1.55645489
15INSRR1.50822686
16ADRBK21.45565847
17ITK1.45301491
18TAOK31.43956248
19TESK11.43112403
20TEC1.40933568
21MYLK1.36811319
22GRK11.36512967
23LIMK11.33605143
24DAPK11.32603284
25CSF1R1.30466372
26PINK11.29632432
27BTK1.29416718
28MST41.27124137
29STK161.24617213
30KIT1.23869090
31WNK41.20226521
32SYK1.19934176
33PIM21.13711372
34RPS6KA41.13366895
35IKBKB1.13181417
36PRKCQ1.12814146
37JAK31.12050218
38RPS6KA51.08539511
39PIK3CA1.06276891
40BUB11.05195556
41VRK10.97962209
42VRK20.94971148
43CCNB10.92388009
44NUAK10.91224217
45LCK0.84235383
46ARAF0.83815064
47DAPK30.83342361
48LYN0.82957547
49GRK70.81253090
50NME10.73795340
51ILK0.73078097
52PIK3CG0.67085740
53MUSK0.64857078
54OXSR10.63625504
55IGF1R0.63604411
56AURKA0.63094727
57LMTK20.61548955
58GRK60.61102330
59CASK0.60390717
60ADRBK10.59416136
61SRPK10.57561705
62TIE10.56761042
63FES0.56685881
64ERBB30.56596686
65PLK40.56401948
66FRK0.51992973
67OBSCN0.50295976
68ZAP700.49711648
69PRKCE0.48240408
70ROCK10.47930339
71MAP2K70.47614995
72ERBB20.47502502
73FLT30.47387694
74TBK10.46806428
75PIM10.46154943
76CSNK1G30.45208714
77PASK0.45099368
78TRPM70.43363471
79PAK10.42919307
80CAMK2G0.42036466
81PRKACA0.41343104
82ATR0.40381506
83CSK0.40330198
84DYRK20.40157792
85AURKB0.39994079
86CSNK2A10.39897494
87PRKCA0.38923883
88ABL20.38247546
89CDC70.37973226
90MAP3K50.37780182
91EGFR0.37679684
92EIF2AK30.36947605
93NTRK10.36626554
94CSNK1G20.35763078
95FGR0.35576228
96INSR0.35460040
97MAPKAPK30.35109326
98HCK0.32921749
99TNK20.31500233
100STK390.31305997

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29649368
2Asthma_Homo sapiens_hsa053103.60533014
3Graft-versus-host disease_Homo sapiens_hsa053323.39038107
4Oxidative phosphorylation_Homo sapiens_hsa001903.34113269
5Primary immunodeficiency_Homo sapiens_hsa053403.12289571
6Allograft rejection_Homo sapiens_hsa053303.11967153
7Autoimmune thyroid disease_Homo sapiens_hsa053203.00605592
8Antigen processing and presentation_Homo sapiens_hsa046122.81028195
9Parkinsons disease_Homo sapiens_hsa050122.75446293
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.66510603
11Type I diabetes mellitus_Homo sapiens_hsa049402.58234303
12Protein export_Homo sapiens_hsa030602.51111540
13Ribosome_Homo sapiens_hsa030102.22880876
14RNA polymerase_Homo sapiens_hsa030202.04836303
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89281395
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75645575
17Alzheimers disease_Homo sapiens_hsa050101.73964956
18Rheumatoid arthritis_Homo sapiens_hsa053231.73603721
19Cardiac muscle contraction_Homo sapiens_hsa042601.70323730
20Systemic lupus erythematosus_Homo sapiens_hsa053221.68666698
21Huntingtons disease_Homo sapiens_hsa050161.62878776
22Hematopoietic cell lineage_Homo sapiens_hsa046401.58668326
23Staphylococcus aureus infection_Homo sapiens_hsa051501.54073148
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44798493
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44178832
26Viral myocarditis_Homo sapiens_hsa054161.43006943
27Phototransduction_Homo sapiens_hsa047441.24058744
28Leishmaniasis_Homo sapiens_hsa051401.20578229
29One carbon pool by folate_Homo sapiens_hsa006701.13083209
30DNA replication_Homo sapiens_hsa030301.10210953
31RNA degradation_Homo sapiens_hsa030181.06166113
32Sulfur relay system_Homo sapiens_hsa041221.02447361
33Regulation of autophagy_Homo sapiens_hsa041401.02122922
34Spliceosome_Homo sapiens_hsa030401.01098326
35Pyrimidine metabolism_Homo sapiens_hsa002400.96494713
36Nitrogen metabolism_Homo sapiens_hsa009100.95011441
37Homologous recombination_Homo sapiens_hsa034400.93403075
38Salmonella infection_Homo sapiens_hsa051320.92018247
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89762668
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89747880
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89387416
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86829092
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85898236
44Peroxisome_Homo sapiens_hsa041460.85505961
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.80421816
46Sulfur metabolism_Homo sapiens_hsa009200.79022103
47Nucleotide excision repair_Homo sapiens_hsa034200.77758110
48Tryptophan metabolism_Homo sapiens_hsa003800.76853741
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75591950
50T cell receptor signaling pathway_Homo sapiens_hsa046600.73023927
51Purine metabolism_Homo sapiens_hsa002300.72986923
52Caffeine metabolism_Homo sapiens_hsa002320.67836761
53Collecting duct acid secretion_Homo sapiens_hsa049660.67748461
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66930534
55Fanconi anemia pathway_Homo sapiens_hsa034600.64439451
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.64186032
57Retinol metabolism_Homo sapiens_hsa008300.63811307
58Chemical carcinogenesis_Homo sapiens_hsa052040.62734576
59Mismatch repair_Homo sapiens_hsa034300.60970416
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59508091
61Propanoate metabolism_Homo sapiens_hsa006400.59390992
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.57611575
63Fatty acid elongation_Homo sapiens_hsa000620.55194644
64Herpes simplex infection_Homo sapiens_hsa051680.54517541
65Base excision repair_Homo sapiens_hsa034100.54399726
66Arachidonic acid metabolism_Homo sapiens_hsa005900.53878116
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52505953
68Olfactory transduction_Homo sapiens_hsa047400.52108567
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47924103
70Epstein-Barr virus infection_Homo sapiens_hsa051690.45582939
71Metabolic pathways_Homo sapiens_hsa011000.43969606
72Legionellosis_Homo sapiens_hsa051340.42839984
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41485998
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.41347759
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41340459
76Fatty acid degradation_Homo sapiens_hsa000710.40294067
77Shigellosis_Homo sapiens_hsa051310.39295180
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36206314
79Tuberculosis_Homo sapiens_hsa051520.36045282
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35369860
81Phagosome_Homo sapiens_hsa041450.35223297
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33904955
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32414200
84Non-homologous end-joining_Homo sapiens_hsa034500.31329254
85Pertussis_Homo sapiens_hsa051330.29944286
86Alcoholism_Homo sapiens_hsa050340.29421779
87RNA transport_Homo sapiens_hsa030130.28998110
88Glutathione metabolism_Homo sapiens_hsa004800.28809982
89Taste transduction_Homo sapiens_hsa047420.28763992
90Tyrosine metabolism_Homo sapiens_hsa003500.28578370
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26898633
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25651106
93Basal transcription factors_Homo sapiens_hsa030220.25410261
94Influenza A_Homo sapiens_hsa051640.25084166
95Linoleic acid metabolism_Homo sapiens_hsa005910.23648461
96Morphine addiction_Homo sapiens_hsa050320.23323460
97Measles_Homo sapiens_hsa051620.23163361
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22875984
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.22505250
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21719259

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »