EIF5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98634331
2mitotic metaphase plate congression (GO:0007080)4.80223563
3mitotic sister chromatid cohesion (GO:0007064)4.64959795
4maturation of SSU-rRNA (GO:0030490)4.63383118
5nuclear pore complex assembly (GO:0051292)4.49713972
6nuclear pore organization (GO:0006999)4.47117579
7kinetochore organization (GO:0051383)4.46126421
8cotranslational protein targeting to membrane (GO:0006613)4.39953095
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39942612
10protein targeting to ER (GO:0045047)4.37094496
11ribosomal small subunit assembly (GO:0000028)4.35017998
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23038690
13kinetochore assembly (GO:0051382)4.14506449
14metaphase plate congression (GO:0051310)4.09607785
15ATP synthesis coupled proton transport (GO:0015986)4.07200284
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07200284
17protein localization to endoplasmic reticulum (GO:0070972)4.03552763
18ribosome assembly (GO:0042255)3.90912435
19cellular protein complex disassembly (GO:0043624)3.86554180
20establishment of integrated proviral latency (GO:0075713)3.85776066
21formation of translation preinitiation complex (GO:0001731)3.84494583
22regulation of RNA export from nucleus (GO:0046831)3.83439452
23DNA replication checkpoint (GO:0000076)3.81719954
24viral life cycle (GO:0019058)3.78834860
25mitotic nuclear envelope disassembly (GO:0007077)3.62172728
26pore complex assembly (GO:0046931)3.61983766
27regulation of spindle organization (GO:0090224)3.59845647
28protein localization to kinetochore (GO:0034501)3.59697662
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55751607
30positive regulation of chromosome segregation (GO:0051984)3.55739320
31regulation of mitotic spindle organization (GO:0060236)3.55677080
32ribosomal large subunit biogenesis (GO:0042273)3.55559192
33ribosomal small subunit biogenesis (GO:0042274)3.52947959
34heterochromatin organization (GO:0070828)3.47786434
35DNA strand elongation involved in DNA replication (GO:0006271)3.47630400
36viral transcription (GO:0019083)3.45401881
37protein complex disassembly (GO:0043241)3.45169987
38translational termination (GO:0006415)3.44739777
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.43296147
40respiratory electron transport chain (GO:0022904)3.40593372
41telomere maintenance via semi-conservative replication (GO:0032201)3.39789155
42DNA topological change (GO:0006265)3.39413173
43protein localization to chromosome, centromeric region (GO:0071459)3.38464076
44* translational initiation (GO:0006413)3.37662683
45* translation (GO:0006412)3.36998159
46negative regulation of DNA repair (GO:0045738)3.35872264
47ribonucleoprotein complex biogenesis (GO:0022613)3.35097466
48DNA strand elongation (GO:0022616)3.34335727
49pre-miRNA processing (GO:0031054)3.34310443
50membrane disassembly (GO:0030397)3.32009858
51nuclear envelope disassembly (GO:0051081)3.32009858
52electron transport chain (GO:0022900)3.31633473
53macromolecular complex disassembly (GO:0032984)3.31426380
54paraxial mesoderm development (GO:0048339)3.30289285
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28522941
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28522941
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.28522941
58chaperone-mediated protein transport (GO:0072321)3.27221751
59mitotic chromosome condensation (GO:0007076)3.25627986
60chromatin remodeling at centromere (GO:0031055)3.25239665
61mitotic sister chromatid segregation (GO:0000070)3.23531587
62DNA replication-independent nucleosome organization (GO:0034724)3.22293759
63DNA replication-independent nucleosome assembly (GO:0006336)3.22293759
64establishment of chromosome localization (GO:0051303)3.22102908
65DNA unwinding involved in DNA replication (GO:0006268)3.21688891
66positive regulation of histone H3-K4 methylation (GO:0051571)3.21380618
67ribosome biogenesis (GO:0042254)3.20791644
68CENP-A containing nucleosome assembly (GO:0034080)3.20009851
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17903641
70cellular component biogenesis (GO:0044085)3.16145982
71spliceosomal complex assembly (GO:0000245)3.16128953
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.15071868
73histone exchange (GO:0043486)3.13863477
74attachment of spindle microtubules to kinetochore (GO:0008608)3.13640807
75spliceosomal snRNP assembly (GO:0000387)3.13112905
76telomere maintenance via recombination (GO:0000722)3.07625629
77RNA splicing, via transesterification reactions (GO:0000375)3.06781608
78rRNA processing (GO:0006364)3.06422943
79regulation of nucleobase-containing compound transport (GO:0032239)3.06142905
80regulation of mitochondrial translation (GO:0070129)3.05251273
81mitotic recombination (GO:0006312)3.05229339
82meiotic chromosome segregation (GO:0045132)3.05198686
83mRNA catabolic process (GO:0006402)3.03135120
84rRNA metabolic process (GO:0016072)3.02705513
85RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02188472
86mRNA splicing, via spliceosome (GO:0000398)3.02188472
87sister chromatid segregation (GO:0000819)3.01613025
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.01437350
89spindle checkpoint (GO:0031577)3.00531879
90regulation of centrosome cycle (GO:0046605)2.98983985
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.98794252
92DNA replication initiation (GO:0006270)2.95717383
93positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.95552629
94alternative mRNA splicing, via spliceosome (GO:0000380)2.95047413
95ATP-dependent chromatin remodeling (GO:0043044)2.94692199
96protein targeting to membrane (GO:0006612)2.94357671
97proteasome assembly (GO:0043248)2.92662195
98regulation of centriole replication (GO:0046599)2.91191105
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90426808
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89580240
101RNA catabolic process (GO:0006401)2.89347804
102sister chromatid cohesion (GO:0007062)2.88740019
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88160578
104negative regulation of histone methylation (GO:0031061)2.87880663
105chromatin assembly or disassembly (GO:0006333)2.87667244
106mitotic spindle checkpoint (GO:0071174)2.86989231
107regulation of gene silencing by RNA (GO:0060966)2.86540859
108regulation of posttranscriptional gene silencing (GO:0060147)2.86540859
109regulation of gene silencing by miRNA (GO:0060964)2.86540859
110termination of RNA polymerase III transcription (GO:0006386)2.85004180
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.85004180
112negative regulation of RNA splicing (GO:0033119)2.84816341
113regulation of double-strand break repair (GO:2000779)2.84449996
114DNA damage response, detection of DNA damage (GO:0042769)2.84312858
115negative regulation of mRNA processing (GO:0050686)2.84088979
116protein K6-linked ubiquitination (GO:0085020)2.83505800
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.83151543
118rRNA modification (GO:0000154)2.82479623
119translational elongation (GO:0006414)2.82456332
120inner mitochondrial membrane organization (GO:0007007)2.82423242
121RNA stabilization (GO:0043489)2.81369617
122mRNA stabilization (GO:0048255)2.81369617
123maturation of 5.8S rRNA (GO:0000460)2.79687193
124protein localization to chromosome (GO:0034502)2.78879779
125regulation of sister chromatid cohesion (GO:0007063)2.77829711
126purine nucleobase biosynthetic process (GO:0009113)2.76749900
127regulation of DNA endoreduplication (GO:0032875)2.75117024
128centriole replication (GO:0007099)2.73907049
129DNA replication-dependent nucleosome assembly (GO:0006335)2.73830452
130DNA replication-dependent nucleosome organization (GO:0034723)2.73830452
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.73408748
132regulation of chromosome segregation (GO:0051983)2.73183033
133inner cell mass cell proliferation (GO:0001833)2.72915610
134negative regulation of chromosome segregation (GO:0051985)2.72331565
135chromosome condensation (GO:0030261)2.71374386
136IMP biosynthetic process (GO:0006188)2.70821826
137transcription-coupled nucleotide-excision repair (GO:0006283)2.70364187
138chromosome segregation (GO:0007059)2.70159616
139mitotic G2/M transition checkpoint (GO:0044818)2.69467849
140nucleobase biosynthetic process (GO:0046112)2.69208908
141regulation of mitotic sister chromatid separation (GO:0010965)2.68804583
142regulation of mitotic sister chromatid segregation (GO:0033047)2.68804583
143regulation of sister chromatid segregation (GO:0033045)2.68804583
144telomere maintenance via telomere lengthening (GO:0010833)2.68365249
145DNA-templated transcription, termination (GO:0006353)2.68114726
146negative regulation of mRNA metabolic process (GO:1903312)2.67500393
147telomere maintenance via telomerase (GO:0007004)2.66862990
148termination of RNA polymerase II transcription (GO:0006369)2.66292069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59562887
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.21712730
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.50550423
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04143103
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64513094
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28222146
7AR_21909140_ChIP-Seq_LNCAP_Human3.00666048
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.87590508
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87113045
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86630252
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74537501
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72363685
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.63579224
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56126502
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.51540687
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49708267
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.47971400
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.29972536
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29941604
20XRN2_22483619_ChIP-Seq_HELA_Human2.29192648
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25009920
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19219588
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16607452
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15959954
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08645600
26TTF2_22483619_ChIP-Seq_HELA_Human2.06457963
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02834852
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.99008302
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90187842
30VDR_23849224_ChIP-Seq_CD4+_Human1.87485177
31KDM5A_27292631_Chip-Seq_BREAST_Human1.86162846
32ELK1_19687146_ChIP-ChIP_HELA_Human1.82159095
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80254189
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.74330726
35DCP1A_22483619_ChIP-Seq_HELA_Human1.72972638
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71378503
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69863368
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69863368
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69863368
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63591657
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.61391458
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58846822
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.58462575
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53870267
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53538002
46* GABP_19822575_ChIP-Seq_HepG2_Human1.50488564
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44847241
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44407992
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44119030
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42284411
51CIITA_25753668_ChIP-Seq_RAJI_Human1.36154621
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35892934
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33853954
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33842647
55* MYC_22102868_ChIP-Seq_BL_Human1.31126811
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30858339
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30537595
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30431193
59* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26172843
60MYC_18940864_ChIP-ChIP_HL60_Human1.24425824
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24393147
62CHD1_26751641_Chip-Seq_LNCaP_Human1.23925606
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23884627
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23838950
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22948655
66EWS_26573619_Chip-Seq_HEK293_Human1.20555837
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15605753
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15338013
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13603164
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.12467270
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07871293
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06214681
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.06184903
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04863816
75* SRF_21415370_ChIP-Seq_HL-1_Mouse1.04771690
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04645417
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04464241
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03598028
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02882930
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01324396
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00569271
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99804107
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99662770
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99420885
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98064767
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.96839283
87* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96609147
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.95595786
89TFEB_21752829_ChIP-Seq_HELA_Human0.94767755
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94636074
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94182232
92FUS_26573619_Chip-Seq_HEK293_Human0.93848336
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93593951
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93156733
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90679135
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90130153
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90004030
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89351426
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.88328093
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87964673
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86627850
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86213585
103ATF3_27146783_Chip-Seq_COLON_Human0.86127901
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.86056201
105* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84047096
106SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82877052
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82165806
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79948237
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79181342
110GATA6_25053715_ChIP-Seq_YYC3_Human0.78505112
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.77504711
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.76951685
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76920202
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76222193
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76171318
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75969943
117VDR_22108803_ChIP-Seq_LS180_Human0.75142010
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74450204
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74183791
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72992979
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72702952
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71367188
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.68314056
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66107280
125MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.65092002
126* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.64928272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.01947524
2MP0009379_abnormal_foot_pigmentation3.97734890
3MP0004957_abnormal_blastocyst_morpholog3.65996856
4MP0003111_abnormal_nucleus_morphology3.47628562
5MP0008057_abnormal_DNA_replication3.40674737
6MP0010094_abnormal_chromosome_stability3.14950503
7MP0003077_abnormal_cell_cycle2.96661837
8MP0008877_abnormal_DNA_methylation2.74943605
9MP0001730_embryonic_growth_arrest2.29135623
10MP0008932_abnormal_embryonic_tissue2.25462282
11MP0005076_abnormal_cell_differentiation2.08146622
12MP0000350_abnormal_cell_proliferation2.05423457
13MP0003123_paternal_imprinting2.02307262
14MP0008058_abnormal_DNA_repair2.00722203
15MP0003567_abnormal_fetal_cardiomyocyte2.00264388
16MP0001188_hyperpigmentation1.99453382
17MP0001672_abnormal_embryogenesis/_devel1.97989566
18MP0005380_embryogenesis_phenotype1.97989566
19MP0003941_abnormal_skin_development1.96446261
20MP0010030_abnormal_orbit_morphology1.95420819
21MP0001697_abnormal_embryo_size1.87091638
22MP0002084_abnormal_developmental_patter1.84249875
23MP0003984_embryonic_growth_retardation1.83598717
24MP0002088_abnormal_embryonic_growth/wei1.80424049
25MP0008007_abnormal_cellular_replicative1.77188706
26MP0002085_abnormal_embryonic_tissue1.74655984
27MP0009053_abnormal_anal_canal1.73195121
28MP0003890_abnormal_embryonic-extraembry1.71861287
29MP0004197_abnormal_fetal_growth/weight/1.70097596
30MP0003937_abnormal_limbs/digits/tail_de1.67721253
31MP0010352_gastrointestinal_tract_polyps1.61040589
32MP0002938_white_spotting1.59083344
33MP0002234_abnormal_pharynx_morphology1.55744532
34MP0004185_abnormal_adipocyte_glucose1.53241197
35MP0010234_abnormal_vibrissa_follicle1.50691464
36MP0000579_abnormal_nail_morphology1.50500931
37MP0002086_abnormal_extraembryonic_tissu1.50202009
38MP0002697_abnormal_eye_size1.47886834
39MP0003718_maternal_effect1.43959324
40MP0002080_prenatal_lethality1.43088410
41MP0003705_abnormal_hypodermis_morpholog1.42814383
42MP0003121_genomic_imprinting1.41004608
43MP0003315_abnormal_perineum_morphology1.36995693
44MP0009697_abnormal_copulation1.35971831
45MP0003755_abnormal_palate_morphology1.35463021
46MP0000432_abnormal_head_morphology1.32791786
47MP0001286_abnormal_eye_development1.28932236
48MP0010307_abnormal_tumor_latency1.28198169
49MP0000428_abnormal_craniofacial_morphol1.22515932
50MP0000750_abnormal_muscle_regeneration1.22379023
51MP0009672_abnormal_birth_weight1.20526143
52MP0000537_abnormal_urethra_morphology1.18461672
53MP0001293_anophthalmia1.18208224
54MP0003385_abnormal_body_wall1.17930983
55MP0009703_decreased_birth_body1.17213562
56MP0002396_abnormal_hematopoietic_system1.16833810
57MP0003786_premature_aging1.11943134
58MP0002210_abnormal_sex_determination1.11231454
59MP0009250_abnormal_appendicular_skeleto1.10870935
60MP0002160_abnormal_reproductive_system1.10476040
61MP0003186_abnormal_redox_activity1.10065484
62MP0001299_abnormal_eye_distance/1.07613850
63MP0006292_abnormal_olfactory_placode1.07381762
64MP0000733_abnormal_muscle_development1.07360637
65MP0003935_abnormal_craniofacial_develop1.05414045
66MP0000313_abnormal_cell_death1.04640085
67MP0000383_abnormal_hair_follicle1.04106031
68MP0003950_abnormal_plasma_membrane1.04078701
69MP0003942_abnormal_urinary_system1.03241164
70MP0003119_abnormal_digestive_system1.02799623
71MP0005187_abnormal_penis_morphology1.01525863
72MP0001529_abnormal_vocalization1.01417779
73MP0000049_abnormal_middle_ear1.00823553
74MP0006035_abnormal_mitochondrial_morpho0.99860238
75MP0003566_abnormal_cell_adhesion0.98902545
76MP0005623_abnormal_meninges_morphology0.96030553
77MP0005499_abnormal_olfactory_system0.94813649
78MP0005394_taste/olfaction_phenotype0.94813649
79MP0001145_abnormal_male_reproductive0.94656350
80MP0005367_renal/urinary_system_phenotyp0.94195834
81MP0000516_abnormal_urinary_system0.94195834
82MP0006036_abnormal_mitochondrial_physio0.93688663
83MP0001915_intracranial_hemorrhage0.91584838
84MP0003221_abnormal_cardiomyocyte_apopto0.90989607
85MP0000762_abnormal_tongue_morphology0.90634582
86MP0002092_abnormal_eye_morphology0.89504368
87MP0003136_yellow_coat_color0.88925726
88MP0002111_abnormal_tail_morphology0.88924568
89MP0000653_abnormal_sex_gland0.88765714
90MP0005193_abnormal_anterior_eye0.88535209
91MP0005501_abnormal_skin_physiology0.87699001
92MP0000566_synostosis0.86765471
93MP0002233_abnormal_nose_morphology0.86315711
94MP0005084_abnormal_gallbladder_morpholo0.85963474
95MP0006072_abnormal_retinal_apoptosis0.85844084
96MP0004808_abnormal_hematopoietic_stem0.85794226
97MP0008789_abnormal_olfactory_epithelium0.85648925
98MP0001929_abnormal_gametogenesis0.85325630
99MP0010678_abnormal_skin_adnexa0.85064309
100MP0002116_abnormal_craniofacial_bone0.84714745
101MP0003828_pulmonary_edema0.84188343
102MP0000631_abnormal_neuroendocrine_gland0.84047541
103MP0000490_abnormal_crypts_of0.83771680
104MP0001849_ear_inflammation0.82508954
105MP0005248_abnormal_Harderian_gland0.81763798
106MP0003787_abnormal_imprinting0.81674121
107MP0003938_abnormal_ear_development0.81112732
108MP0002925_abnormal_cardiovascular_devel0.80153533
109MP0003861_abnormal_nervous_system0.79975404
110MP0010630_abnormal_cardiac_muscle0.78343350
111MP0002114_abnormal_axial_skeleton0.78240461
112MP0000627_abnormal_mammary_gland0.77075242
113MP0000266_abnormal_heart_morphology0.76816640
114MP0005257_abnormal_intraocular_pressure0.76717362
115MP0002019_abnormal_tumor_incidence0.76177924
116MP0002098_abnormal_vibrissa_morphology0.76163296
117MP0002796_impaired_skin_barrier0.76053652
118MP0000377_abnormal_hair_follicle0.75874618
119MP0004145_abnormal_muscle_electrophysio0.75032092
120MP0004264_abnormal_extraembryonic_tissu0.73512353
121MP0001346_abnormal_lacrimal_gland0.71625162
122MP0004215_abnormal_myocardial_fiber0.66041516
123MP0001881_abnormal_mammary_gland0.64355795
124MP0002089_abnormal_postnatal_growth/wei0.64225114
125MP0002161_abnormal_fertility/fecundity0.61860132
126MP0005503_abnormal_tendon_morphology0.61689827
127MP0000358_abnormal_cell_content/0.61108603
128MP0002081_perinatal_lethality0.60756955
129MP0003936_abnormal_reproductive_system0.59388921
130MP0003698_abnormal_male_reproductive0.59096355
131MP0001485_abnormal_pinna_reflex0.58568416
132MP0003699_abnormal_female_reproductive0.58144883
133MP0005408_hypopigmentation0.58070339

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.85250436
2Volvulus (HP:0002580)3.81469242
3Breast hypoplasia (HP:0003187)3.37110376
4Increased hepatocellular lipid droplets (HP:0006565)3.35700950
5Abnormal mitochondria in muscle tissue (HP:0008316)3.33942339
6Acute encephalopathy (HP:0006846)3.31812234
7Patellar aplasia (HP:0006443)3.29935789
8Aplasia/Hypoplasia of the patella (HP:0006498)3.23806675
9Facial hemangioma (HP:0000329)3.20231347
10Chromsome breakage (HP:0040012)3.14808117
11Rib fusion (HP:0000902)3.10385869
12Progressive macrocephaly (HP:0004481)3.02711641
13Sparse lateral eyebrow (HP:0005338)2.98376193
14Proximal placement of thumb (HP:0009623)2.91459667
15Birth length less than 3rd percentile (HP:0003561)2.86125726
16Abnormality of the labia minora (HP:0012880)2.84877420
17Lipid accumulation in hepatocytes (HP:0006561)2.84591043
18Nuclear cataract (HP:0100018)2.82408873
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.80126822
20Reticulocytopenia (HP:0001896)2.79934215
21Ectopic kidney (HP:0000086)2.78853026
22Deviation of the thumb (HP:0009603)2.77036457
23Multiple enchondromatosis (HP:0005701)2.73432993
24Increased CSF lactate (HP:0002490)2.70030322
25Septo-optic dysplasia (HP:0100842)2.67135827
26Oligodactyly (HP:0012165)2.66728132
27Abnormal number of incisors (HP:0011064)2.63367190
28Impulsivity (HP:0100710)2.62153337
29Mitochondrial inheritance (HP:0001427)2.61210568
30Cerebral edema (HP:0002181)2.59695571
31Rectal prolapse (HP:0002035)2.58761839
32Absent radius (HP:0003974)2.57264634
33Supernumerary ribs (HP:0005815)2.56418200
34Macrocytic anemia (HP:0001972)2.54945938
35Horseshoe kidney (HP:0000085)2.50865029
36Supernumerary bones of the axial skeleton (HP:0009144)2.50411891
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48681431
38Long eyelashes (HP:0000527)2.43532970
39Colon cancer (HP:0003003)2.43176504
40Aplasia involving forearm bones (HP:0009822)2.42374782
41Absent forearm bone (HP:0003953)2.42374782
42Abnormality of the preputium (HP:0100587)2.34855560
43Atresia of the external auditory canal (HP:0000413)2.33868900
44Zonular cataract (HP:0010920)2.32112058
45Absent septum pellucidum (HP:0001331)2.31597421
46Prominent nose (HP:0000448)2.27019393
47Meckel diverticulum (HP:0002245)2.21507522
48Abnormality of the septum pellucidum (HP:0007375)2.18808549
49Nephroblastoma (Wilms tumor) (HP:0002667)2.17898250
50Abnormality of cells of the erythroid lineage (HP:0012130)2.17825299
51Aplastic anemia (HP:0001915)2.17186602
52Respiratory difficulties (HP:0002880)2.17020529
53Biliary tract neoplasm (HP:0100574)2.17015413
54Short middle phalanx of the 5th finger (HP:0004220)2.16377836
55Shawl scrotum (HP:0000049)2.16362970
56Aplasia cutis congenita (HP:0001057)2.15406047
57Abnormal hemoglobin (HP:0011902)2.14950893
58Blepharitis (HP:0000498)2.14069378
59Absent thumb (HP:0009777)2.13531099
60Carpal bone hypoplasia (HP:0001498)2.11105022
61Increased serum pyruvate (HP:0003542)2.09220988
62Partial duplication of thumb phalanx (HP:0009944)2.08947653
63Renal Fanconi syndrome (HP:0001994)2.08338981
64Abnormality of the fingertips (HP:0001211)2.07179489
65Lip pit (HP:0100267)2.06735763
66Triphalangeal thumb (HP:0001199)2.05005900
67Embryonal renal neoplasm (HP:0011794)2.05002279
68Hyperglycinemia (HP:0002154)2.03426241
69Leukodystrophy (HP:0002415)2.03255211
70Abnormality of the ileum (HP:0001549)2.02565359
71Abnormality of chromosome stability (HP:0003220)2.02410630
72Increased nuchal translucency (HP:0010880)2.02104767
73Rough bone trabeculation (HP:0100670)2.01252187
74Ependymoma (HP:0002888)2.00997205
75Partial duplication of the phalanx of hand (HP:0009999)1.99892106
76Microtia (HP:0008551)1.98807008
77Concave nail (HP:0001598)1.98187632
78Urethral obstruction (HP:0000796)1.95780581
79Short thumb (HP:0009778)1.95099638
80Selective tooth agenesis (HP:0001592)1.94348593
81Pallor (HP:0000980)1.93432907
82Premature ovarian failure (HP:0008209)1.90705963
83Methylmalonic acidemia (HP:0002912)1.90241261
84Neoplasm of the pancreas (HP:0002894)1.88207062
85Supernumerary spleens (HP:0009799)1.88178767
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86230044
87Squamous cell carcinoma (HP:0002860)1.86121186
88Maternal diabetes (HP:0009800)1.85055180
89Anal stenosis (HP:0002025)1.84796645
90Abnormality of glycolysis (HP:0004366)1.84793831
91Abnormal number of erythroid precursors (HP:0012131)1.83983669
92Duplication of thumb phalanx (HP:0009942)1.83435839
93Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81941381
94Hypoplasia of the pons (HP:0012110)1.81879334
95Oligodactyly (hands) (HP:0001180)1.81746055
96Homocystinuria (HP:0002156)1.81382435
97Abnormality of homocysteine metabolism (HP:0010919)1.81382435
98Capillary hemangiomas (HP:0005306)1.80850244
99Duodenal stenosis (HP:0100867)1.80809398
100Small intestinal stenosis (HP:0012848)1.80809398
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.79956521
102Abnormality of the carotid arteries (HP:0005344)1.79532777
103Abnormality of the anterior horn cell (HP:0006802)1.79396613
104Degeneration of anterior horn cells (HP:0002398)1.79396613
105Fused cervical vertebrae (HP:0002949)1.78423560
106Short 1st metacarpal (HP:0010034)1.77180254
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.77180254
108Increased intramyocellular lipid droplets (HP:0012240)1.77101358
109Trismus (HP:0000211)1.76862052
110Abnormality of the parietal bone (HP:0002696)1.76628120
111Aplasia/hypoplasia of the humerus (HP:0006507)1.76129448
112Choanal atresia (HP:0000453)1.75853498
113Exercise intolerance (HP:0003546)1.74943021
114Muscle fiber splitting (HP:0003555)1.74153896
115Secondary amenorrhea (HP:0000869)1.73796354
116Missing ribs (HP:0000921)1.73438324
117Abnormality of the duodenum (HP:0002246)1.73383551
118Progressive muscle weakness (HP:0003323)1.72885906
119Congenital, generalized hypertrichosis (HP:0004540)1.72731522
120Overlapping toe (HP:0001845)1.72638299
121Hemivertebrae (HP:0002937)1.72004587
122Increased serum lactate (HP:0002151)1.71727449
123Myelodysplasia (HP:0002863)1.71339313
124Bilateral microphthalmos (HP:0007633)1.71011732
125Medulloblastoma (HP:0002885)1.70685653
126Oligodontia (HP:0000677)1.70293405
127Nasolacrimal duct obstruction (HP:0000579)1.70234307
128Hepatocellular necrosis (HP:0001404)1.70197765
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69907550
130Megaloblastic anemia (HP:0001889)1.69532737
131Pelvic girdle muscle weakness (HP:0003749)1.69275627
132Oral leukoplakia (HP:0002745)1.68546075
133Adrenal hypoplasia (HP:0000835)1.66903492
134Exertional dyspnea (HP:0002875)1.66522645
135Hepatic necrosis (HP:0002605)1.66444351
136Vertebral fusion (HP:0002948)1.66322230
137Abnormality of the incisor (HP:0000676)1.65325770
138Abnormality of DNA repair (HP:0003254)1.65007550
139Abnormality of the pons (HP:0007361)1.64253123
140Abnormality of the nasal septum (HP:0000419)1.63023409
141Abnormal lung lobation (HP:0002101)1.62986377
142Hypoplasia of the radius (HP:0002984)1.62851924
143Pili torti (HP:0003777)1.62460471
144Sparse eyelashes (HP:0000653)1.62399735
145Esophageal atresia (HP:0002032)1.62206043
146Facial cleft (HP:0002006)1.61977219
147Microvesicular hepatic steatosis (HP:0001414)1.61655698
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.61626827
149Broad hallux (HP:0010055)1.59997037
150Pancytopenia (HP:0001876)1.59663521
151Abnormality of the lacrimal duct (HP:0011481)1.58884273
152Abnormality of renal resorption (HP:0011038)1.58816311
153Neoplasm of the colon (HP:0100273)1.58805781
154Broad thumb (HP:0011304)1.58597308
155Microglossia (HP:0000171)1.58302220
156Anal atresia (HP:0002023)1.58220990
157Optic disc pallor (HP:0000543)1.58051542
158Sparse scalp hair (HP:0002209)1.57331670
159Abnormality of methionine metabolism (HP:0010901)1.56677599
160Abnormality of cochlea (HP:0000375)1.54935594
161Abnormality of serum amino acid levels (HP:0003112)1.53784672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.48584319
2STK164.46354500
3CDC74.44410003
4PNCK3.67376656
5VRK23.43144762
6EIF2AK13.20928985
7SRPK12.98894768
8LATS12.97067377
9WEE12.87401353
10PLK42.83671026
11MKNK12.82534382
12MKNK22.78971031
13TAF12.23351966
14TTK2.22620413
15NEK22.13421119
16BUB12.11371272
17TNIK2.10320399
18LATS21.93491398
19MST41.84351786
20PLK31.76019256
21NME21.69746573
22STK31.69342646
23CDK71.67878297
24PLK11.67843653
25BRD41.66487313
26STK38L1.57759568
27CHEK21.53841733
28CHEK11.51023140
29AURKB1.50208231
30CDK61.48701128
31PDK21.37631813
32STK101.37216309
33CDK41.33459308
34TLK11.31243775
35PBK1.29612680
36RPS6KA41.27056865
37DMPK1.22984944
38ATM1.20845905
39TAOK11.19957981
40MAP3K91.19250398
41STK41.18732853
42ALK1.18666964
43NUAK11.18000601
44MAP3K81.15512076
45NME11.12915945
46* CSNK1E1.12594815
47ATR1.10312483
48TAOK31.07879087
49BRSK21.06561792
50WNK41.06139260
51PASK1.06095503
52* CDK21.05181185
53TSSK61.03981512
54MTOR1.03272605
55MELK1.00640340
56AURKA0.94659599
57EPHA20.93388691
58TYRO30.92884215
59CSNK2A20.90040219
60PAK20.89173815
61EPHB20.85558342
62CDK10.83353193
63BRSK10.81643103
64RPS6KB20.79808921
65PLK20.79119926
66DYRK20.76597650
67CASK0.75878304
68PIM20.74663280
69PIM10.71335229
70DYRK30.68610351
71PRKCI0.67353814
72BMPR1B0.64147881
73CSNK2A10.63416995
74EIF2AK30.63355646
75ICK0.61441898
76ZAK0.59685930
77ACVR1B0.58894160
78TGFBR10.57873452
79PRKDC0.57769492
80SMG10.57400134
81CSNK1D0.57193962
82CLK10.55129678
83CSNK1G10.53982770
84STK390.52841494
85* MAPK140.51178290
86MAP3K100.50688459
87BRAF0.50619107
88CCNB10.49430318
89EIF2AK20.49013164
90BLK0.48538165
91PIK3CA0.47694002
92CDK80.47558328
93ARAF0.46645343
94CSNK1A1L0.45503736
95NEK10.45431788
96CDK90.44294936
97GSK3B0.44168389
98PAK10.44021188
99TTN0.42840636
100ABL20.41740146
101MAPK100.41655521
102ERBB40.41428532
103PRKCG0.40950618
104BMX0.39778243
105MAPKAPK50.38695629
106PTK20.37544189
107CDK11A0.37175756
108PRKACB0.36452798
109LRRK20.36119827
110TRIM280.35955432
111CDK30.35611891
112STK240.35549152
113AKT10.35053764
114VRK10.34895140
115RAF10.34748294
116MAP2K20.34597560
117ILK0.33854188
118WNK10.33146338
119CSNK1G30.32984575
120CHUK0.32980163
121MAP3K50.32552531
122TESK20.31868271
123AKT20.31753080
124CAMK1G0.29890550
125MAPK10.29869396
126MARK30.28491635
127NEK90.28283869
128MET0.27980975
129FGR0.27806940
130CDK150.27699589
131FGFR10.27384258
132WNK30.27237156
133MINK10.25914372
134TAOK20.25572864

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.11027944
2Spliceosome_Homo sapiens_hsa030403.77779585
3* RNA transport_Homo sapiens_hsa030133.59267398
4RNA polymerase_Homo sapiens_hsa030203.40189871
5Ribosome_Homo sapiens_hsa030103.32518650
6DNA replication_Homo sapiens_hsa030303.11819722
7Mismatch repair_Homo sapiens_hsa034302.96775748
8Cell cycle_Homo sapiens_hsa041102.93100802
9Proteasome_Homo sapiens_hsa030502.59254148
10Homologous recombination_Homo sapiens_hsa034402.58597656
11Basal transcription factors_Homo sapiens_hsa030222.57350647
12mRNA surveillance pathway_Homo sapiens_hsa030152.53958529
13Fanconi anemia pathway_Homo sapiens_hsa034602.32535096
14Nucleotide excision repair_Homo sapiens_hsa034202.25894420
15RNA degradation_Homo sapiens_hsa030182.17035265
16Non-homologous end-joining_Homo sapiens_hsa034502.06194254
17Base excision repair_Homo sapiens_hsa034102.02862034
18p53 signaling pathway_Homo sapiens_hsa041151.97480223
19One carbon pool by folate_Homo sapiens_hsa006701.84635272
20Pyrimidine metabolism_Homo sapiens_hsa002401.64844349
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50321614
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49057169
23MicroRNAs in cancer_Homo sapiens_hsa052061.46048476
24Epstein-Barr virus infection_Homo sapiens_hsa051691.34447961
25Pyruvate metabolism_Homo sapiens_hsa006201.29863336
26Oocyte meiosis_Homo sapiens_hsa041141.27971877
27Adherens junction_Homo sapiens_hsa045201.26197136
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21266245
29Hippo signaling pathway_Homo sapiens_hsa043901.16530798
30TGF-beta signaling pathway_Homo sapiens_hsa043501.16291001
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11004997
32Folate biosynthesis_Homo sapiens_hsa007901.10832752
33Small cell lung cancer_Homo sapiens_hsa052221.07890070
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07373276
35Basal cell carcinoma_Homo sapiens_hsa052171.04409062
36Propanoate metabolism_Homo sapiens_hsa006401.03481044
37Herpes simplex infection_Homo sapiens_hsa051680.98913702
38Huntingtons disease_Homo sapiens_hsa050160.97482806
39Prostate cancer_Homo sapiens_hsa052150.91451228
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91213779
41HTLV-I infection_Homo sapiens_hsa051660.90002904
42Tight junction_Homo sapiens_hsa045300.88891309
43Thyroid cancer_Homo sapiens_hsa052160.86300488
44Wnt signaling pathway_Homo sapiens_hsa043100.84272974
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82705785
46Steroid biosynthesis_Homo sapiens_hsa001000.80937665
47Hedgehog signaling pathway_Homo sapiens_hsa043400.79563071
48Vitamin B6 metabolism_Homo sapiens_hsa007500.79045402
49Antigen processing and presentation_Homo sapiens_hsa046120.78295070
50Notch signaling pathway_Homo sapiens_hsa043300.78232532
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77463454
52Purine metabolism_Homo sapiens_hsa002300.76994152
53Viral myocarditis_Homo sapiens_hsa054160.76948032
54Renal cell carcinoma_Homo sapiens_hsa052110.75525778
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74308191
56Viral carcinogenesis_Homo sapiens_hsa052030.72830694
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71688851
58Chronic myeloid leukemia_Homo sapiens_hsa052200.70165455
59Selenocompound metabolism_Homo sapiens_hsa004500.68687668
60Pathways in cancer_Homo sapiens_hsa052000.68292482
61Lysine degradation_Homo sapiens_hsa003100.67640690
62Melanoma_Homo sapiens_hsa052180.66580553
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65465326
64Bladder cancer_Homo sapiens_hsa052190.63185572
65ECM-receptor interaction_Homo sapiens_hsa045120.63084164
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61918754
67Proteoglycans in cancer_Homo sapiens_hsa052050.61580151
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61397381
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61025690
70Biosynthesis of amino acids_Homo sapiens_hsa012300.58035175
71Vitamin digestion and absorption_Homo sapiens_hsa049770.57940050
72Protein export_Homo sapiens_hsa030600.56901813
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56699527
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53977143
75Carbon metabolism_Homo sapiens_hsa012000.53114317
76Sulfur relay system_Homo sapiens_hsa041220.52567661
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52117363
78Glutathione metabolism_Homo sapiens_hsa004800.51190376
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49218807
80FoxO signaling pathway_Homo sapiens_hsa040680.48836994
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48592940
82HIF-1 signaling pathway_Homo sapiens_hsa040660.48384483
83Oxidative phosphorylation_Homo sapiens_hsa001900.48315897
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48071477
85Colorectal cancer_Homo sapiens_hsa052100.47522956
86Parkinsons disease_Homo sapiens_hsa050120.47440691
87Metabolic pathways_Homo sapiens_hsa011000.47025820
88mTOR signaling pathway_Homo sapiens_hsa041500.43842450
89Focal adhesion_Homo sapiens_hsa045100.42638783
90Hepatitis B_Homo sapiens_hsa051610.40993525
91Pancreatic cancer_Homo sapiens_hsa052120.40939598
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39407552
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.38734976
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38522862
95Arginine and proline metabolism_Homo sapiens_hsa003300.37106847
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36394591
97Alzheimers disease_Homo sapiens_hsa050100.33236283
98Apoptosis_Homo sapiens_hsa042100.33018975
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32128611
100Cardiac muscle contraction_Homo sapiens_hsa042600.31485426
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.31169763
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31109659
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30650222
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29036701
105Dorso-ventral axis formation_Homo sapiens_hsa043200.28902818
106Acute myeloid leukemia_Homo sapiens_hsa052210.28510139
107Shigellosis_Homo sapiens_hsa051310.27924835
108Dilated cardiomyopathy_Homo sapiens_hsa054140.26437676
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25429684
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.24934083
111Endometrial cancer_Homo sapiens_hsa052130.23782931
112Linoleic acid metabolism_Homo sapiens_hsa005910.23610655
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22102158
114Hematopoietic cell lineage_Homo sapiens_hsa046400.21073461
115Glioma_Homo sapiens_hsa052140.20822742
116Non-small cell lung cancer_Homo sapiens_hsa052230.20521890
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20431040
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20278417
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19341557
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18280950
121Fatty acid elongation_Homo sapiens_hsa000620.18024400
122Influenza A_Homo sapiens_hsa051640.17924031
123Olfactory transduction_Homo sapiens_hsa047400.16122549
124Axon guidance_Homo sapiens_hsa043600.15850000
125Fatty acid metabolism_Homo sapiens_hsa012120.15639395
126AMPK signaling pathway_Homo sapiens_hsa041520.15035627
127N-Glycan biosynthesis_Homo sapiens_hsa005100.14902356
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14833422
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14242485
130beta-Alanine metabolism_Homo sapiens_hsa004100.13784601
131Fatty acid degradation_Homo sapiens_hsa000710.13276091
132Nicotine addiction_Homo sapiens_hsa050330.12145309
133Phototransduction_Homo sapiens_hsa047440.12139519
134Butanoate metabolism_Homo sapiens_hsa006500.11182964
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.09918810
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09742049
137Melanogenesis_Homo sapiens_hsa049160.09564570
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06605440
139Tyrosine metabolism_Homo sapiens_hsa003500.05818670
140Caffeine metabolism_Homo sapiens_hsa002320.04557220

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