ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.05640408
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.05640408
3	folic acid-containing compound biosynthetic process (GO:0009396)	5.75123296
4	purine nucleotide salvage (GO:0032261)	5.47928842
5	L-serine metabolic process (GO:0006563)	5.38634340
6	homocysteine metabolic process (GO:0050667)	5.17936825
7	adenosine metabolic process (GO:0046085)	4.92416967
8	protein-cofactor linkage (GO:0018065)	4.85813897
9	microtubule nucleation (GO:0007020)	4.81024997
10	regulation of plasminogen activation (GO:0010755)	4.78673443
11	rRNA methylation (GO:0031167)	4.77812934
12	rRNA modification (GO:0000154)	4.73337303
13	response to gravity (GO:0009629)	4.65572890
14	sulfur amino acid catabolic process (GO:0000098)	4.54058280
15	muscle atrophy (GO:0014889)	4.43026733
16	pteridine-containing compound biosynthetic process (GO:0042559)	4.43017945
17	regulation of vitamin D biosynthetic process (GO:0060556)	4.35034117
18	negative regulation of keratinocyte proliferation (GO:0010839)	4.30694725
19	behavioral response to nicotine (GO:0035095)	4.26430291
20	cysteine metabolic process (GO:0006534)	4.25543705
21	serine family amino acid biosynthetic process (GO:0009070)	4.11712348
22	galactose catabolic process (GO:0019388)	4.07698464
23	DNA double-strand break processing (GO:0000729)	3.89993582
24	positive regulation of endothelial cell differentiation (GO:0045603)	3.89517894
25	negative regulation of DNA biosynthetic process (GO:2000279)	3.88351243
26	polyamine biosynthetic process (GO:0006596)	3.87955567
27	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.87569117
28	alternative mRNA splicing, via spliceosome (GO:0000380)	3.87542394
29	white fat cell differentiation (GO:0050872)	3.84562687
30	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.84059220
31	CENP-A containing nucleosome assembly (GO:0034080)	3.80014211
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.78660290
33	protein neddylation (GO:0045116)	3.73787950
34	chromatin remodeling at centromere (GO:0031055)	3.69956877
35	skeletal muscle tissue regeneration (GO:0043403)	3.67367349
36	negative regulation of Ras GTPase activity (GO:0034261)	3.64445615
37	striated muscle atrophy (GO:0014891)	3.64015920
38	inner ear receptor cell development (GO:0060119)	3.56629050
39	tetrahydrofolate metabolic process (GO:0046653)	3.55883342
40	mitochondrial RNA metabolic process (GO:0000959)	3.53109901
41	regulation of vitamin metabolic process (GO:0030656)	3.51179346
42	skeletal muscle adaptation (GO:0043501)	3.49266694
43	kinetochore assembly (GO:0051382)	3.49063375
44	response to caffeine (GO:0031000)	3.38554155
45	platelet dense granule organization (GO:0060155)	3.37902950
46	primary amino compound metabolic process (GO:1901160)	3.35714159
47	pseudouridine synthesis (GO:0001522)	3.31092375
48	IMP biosynthetic process (GO:0006188)	3.31072295
49	polyamine metabolic process (GO:0006595)	3.29691869
50	folic acid-containing compound metabolic process (GO:0006760)	3.27273645
51	cochlea development (GO:0090102)	3.26268124
52	protein K6-linked ubiquitination (GO:0085020)	3.25987825
53	kinetochore organization (GO:0051383)	3.21202906
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13789244
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13789244
56	NADH dehydrogenase complex assembly (GO:0010257)	3.13789244
57	protein complex biogenesis (GO:0070271)	3.13389238
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.11529720
59	ATP synthesis coupled proton transport (GO:0015986)	3.11529720
60	galactose metabolic process (GO:0006012)	3.10740189
61	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.10456162
62	purine-containing compound salvage (GO:0043101)	3.08884983
63	nucleoside transmembrane transport (GO:1901642)	3.03400080
64	regulation of endothelial cell differentiation (GO:0045601)	3.02166945
65	histone exchange (GO:0043486)	3.00527344
66	negative regulation of catenin import into nucleus (GO:0035414)	2.98333963
67	serine family amino acid catabolic process (GO:0009071)	2.94984402
68	DNA replication-independent nucleosome organization (GO:0034724)	2.92563354
69	DNA replication-independent nucleosome assembly (GO:0006336)	2.92563354
70	pteridine-containing compound metabolic process (GO:0042558)	2.91221944
71	transcription from mitochondrial promoter (GO:0006390)	2.89260968
72	cartilage morphogenesis (GO:0060536)	2.85681715
73	inner mitochondrial membrane organization (GO:0007007)	2.83869161
74	positive regulation of glycolytic process (GO:0045821)	2.80441594
75	postsynaptic membrane organization (GO:0001941)	2.79261871
76	regulation of centriole replication (GO:0046599)	2.74792151
77	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74751501
78	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.74349456
79	nucleotide salvage (GO:0043173)	2.72955730
80	cellular biogenic amine biosynthetic process (GO:0042401)	2.72951198
81	L-fucose catabolic process (GO:0042355)	2.70507970
82	fucose catabolic process (GO:0019317)	2.70507970
83	L-fucose metabolic process (GO:0042354)	2.70507970
84	ovulation cycle (GO:0042698)	2.70122631
85	ribosome biogenesis (GO:0042254)	2.69191010
86	IMP metabolic process (GO:0046040)	2.67250716
87	regulation of mitochondrial translation (GO:0070129)	2.65461686
88	DNA strand renaturation (GO:0000733)	2.64172322
89	behavioral defense response (GO:0002209)	2.63853505
90	behavioral fear response (GO:0001662)	2.63853505
91	regulation of skeletal muscle contraction (GO:0014819)	2.62731827
92	replication fork processing (GO:0031297)	2.60139281
93	negative regulation of thymocyte apoptotic process (GO:0070244)	2.58092638
94	regulation of mitochondrial fission (GO:0090140)	2.55821752
95	tRNA processing (GO:0008033)	2.55362807
96	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.54740373
97	nonmotile primary cilium assembly (GO:0035058)	2.53476813
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53403738
99	nucleobase biosynthetic process (GO:0046112)	2.52271683
100	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.51180121

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.85671014
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.36408154
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.00800134
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.73176548
5	VDR_22108803_ChIP-Seq_LS180_Human	3.28339472
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.98490713
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.68710926
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.59928661
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52349143
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21506738
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19935428
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.14357302
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13267039
14	EWS_26573619_Chip-Seq_HEK293_Human	2.08876767
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05844780
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95231077
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.87226121
18	FUS_26573619_Chip-Seq_HEK293_Human	1.86058329
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.84742961
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69138889
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65648733
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.65316006
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60410190
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58432015
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57027121
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56929608
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.56374969
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53663378
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52669139
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48139971
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.43722076
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42575071
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41454210
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.39319809
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.38834728
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.38813233
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.38152707
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37707833
39	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.34560911
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.33764268
41	P300_19829295_ChIP-Seq_ESCs_Human	1.33726818
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.32469154
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28780776
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28085166
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26349678
46	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.25631347
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25302678
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.24725094
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.24620716
50	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.21593995
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21229408
52	NCOR_22424771_ChIP-Seq_293T_Human	1.18551599
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17089033
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15798790
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15410430
56	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14465415
57	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10600882
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.10244236
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10111468
60	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08794558
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.08198049
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07382757
63	GBX2_23144817_ChIP-Seq_PC3_Human	1.05711214
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05710265
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.05419752
66	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05095582
67	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05065749
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02314447
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.01867969
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00380935
71	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99941406
72	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99941406
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99054547
74	AR_21572438_ChIP-Seq_LNCaP_Human	0.99044863
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99017179
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97787590
77	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97549768
78	MYC_18940864_ChIP-ChIP_HL60_Human	0.95624816
79	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.95111941
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95001164
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93141976
82	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93141976
83	CDX2_22108803_ChIP-Seq_LS180_Human	0.92257418
84	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90294946
85	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.89924551
86	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88942083
87	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88744547
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.87792308
89	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87382751
90	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.87358596
91	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.87053495
92	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.86249426
93	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.84798406
94	XRN2_22483619_ChIP-Seq_HELA_Human	0.84563110
95	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.84471359
96	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.82977180
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.82620724
98	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.81166553
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.80766104
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.80046070

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005646_abnormal_pituitary_gland	4.40239738
2	MP0002736_abnormal_nociception_after	3.43975130
3	MP0004147_increased_porphyrin_level	3.27232808
4	MP0006292_abnormal_olfactory_placode	2.91967725
5	MP0005670_abnormal_white_adipose	2.76367946
6	MP0003705_abnormal_hypodermis_morpholog	2.68844070
7	MP0001661_extended_life_span	2.52863493
8	MP0005187_abnormal_penis_morphology	2.44115225
9	MP0005360_urolithiasis	2.42684934
10	MP0001968_abnormal_touch/_nociception	2.39860723
11	MP0004885_abnormal_endolymph	2.32838191
12	MP0000516_abnormal_urinary_system	2.30037260
13	MP0005367_renal/urinary_system_phenotyp	2.30037260
14	MP0002938_white_spotting	2.23590320
15	MP0009697_abnormal_copulation	2.21740708
16	MP0003646_muscle_fatigue	2.16588252
17	MP0002095_abnormal_skin_pigmentation	1.98276290
18	MP0006072_abnormal_retinal_apoptosis	1.90785531
19	MP0002837_dystrophic_cardiac_calcinosis	1.89525583
20	MP0001529_abnormal_vocalization	1.80944683
21	MP0000631_abnormal_neuroendocrine_gland	1.74995554
22	MP0003786_premature_aging	1.72303595
23	MP0008995_early_reproductive_senescence	1.71536832
24	MP0003183_abnormal_peptide_metabolism	1.69187828
25	MP0003315_abnormal_perineum_morphology	1.68422660
26	MP0000747_muscle_weakness	1.64258727
27	MP0008872_abnormal_physiological_respon	1.60505161
28	MP0009780_abnormal_chondrocyte_physiolo	1.59318235
29	MP0000647_abnormal_sebaceous_gland	1.46181797
30	MP0002160_abnormal_reproductive_system	1.43280280
31	MP0005551_abnormal_eye_electrophysiolog	1.38258598
32	MP0000013_abnormal_adipose_tissue	1.36938769
33	MP0001485_abnormal_pinna_reflex	1.35792564
34	MP0004133_heterotaxia	1.35183718
35	MP0000049_abnormal_middle_ear	1.34827955
36	MP0002735_abnormal_chemical_nociception	1.25624892
37	MP0005253_abnormal_eye_physiology	1.25316919
38	MP0005332_abnormal_amino_acid	1.25165192
39	MP0000534_abnormal_ureter_morphology	1.19062314
40	MP0010094_abnormal_chromosome_stability	1.17433750
41	MP0000566_synostosis	1.17432724
42	MP0006276_abnormal_autonomic_nervous	1.16479218
43	MP0000678_abnormal_parathyroid_gland	1.15996590
44	MP0002269_muscular_atrophy	1.14337199
45	MP0002108_abnormal_muscle_morphology	1.13332124
46	MP0004142_abnormal_muscle_tone	1.10249548
47	MP0004270_analgesia	1.08193855
48	MP0000749_muscle_degeneration	1.08122269
49	MP0003937_abnormal_limbs/digits/tail_de	1.07048983
50	MP0000372_irregular_coat_pigmentation	1.06157393
51	MP0005084_abnormal_gallbladder_morpholo	1.04957940
52	MP0002234_abnormal_pharynx_morphology	1.04853276
53	MP0000026_abnormal_inner_ear	1.04524634
54	MP0009745_abnormal_behavioral_response	1.04194620
55	MP0002282_abnormal_trachea_morphology	1.03235170
56	MP0004145_abnormal_muscle_electrophysio	1.02965064
57	MP0001905_abnormal_dopamine_level	1.01384207
58	MP0004742_abnormal_vestibular_system	0.99447450
59	MP0009379_abnormal_foot_pigmentation	0.99174286
60	MP0002638_abnormal_pupillary_reflex	0.98434553
61	MP0001293_anophthalmia	0.95372227
62	MP0003567_abnormal_fetal_cardiomyocyte	0.95237171
63	MP0003186_abnormal_redox_activity	0.94921430
64	MP0003638_abnormal_response/metabolism_	0.92925617
65	MP0001486_abnormal_startle_reflex	0.92815762
66	MP0000653_abnormal_sex_gland	0.91650775
67	MP0002210_abnormal_sex_determination	0.91634596
68	MP0001963_abnormal_hearing_physiology	0.90828759
69	MP0004957_abnormal_blastocyst_morpholog	0.90559526
70	MP0001727_abnormal_embryo_implantation	0.90237520
71	MP0003880_abnormal_central_pattern	0.89753644
72	MP0003136_yellow_coat_color	0.88949007
73	MP0005389_reproductive_system_phenotype	0.88525296
74	MP0003693_abnormal_embryo_hatching	0.86965040
75	MP0001764_abnormal_homeostasis	0.86355404
76	MP0005083_abnormal_biliary_tract	0.86119891
77	MP0003252_abnormal_bile_duct	0.85532340
78	MP0000613_abnormal_salivary_gland	0.84338419
79	MP0002089_abnormal_postnatal_growth/wei	0.84009915
80	MP0002697_abnormal_eye_size	0.82687517
81	MP0003111_abnormal_nucleus_morphology	0.82662825
82	MP0003942_abnormal_urinary_system	0.82032055
83	MP0004215_abnormal_myocardial_fiber	0.81963522
84	MP0002184_abnormal_innervation	0.81836164
85	MP0002067_abnormal_sensory_capabilities	0.80130180
86	MP0003806_abnormal_nucleotide_metabolis	0.79768770
87	MP0005636_abnormal_mineral_homeostasis	0.78141567
88	MP0009250_abnormal_appendicular_skeleto	0.77888432
89	MP0001145_abnormal_male_reproductive	0.77499098
90	MP0009053_abnormal_anal_canal	0.75386631
91	MP0002069_abnormal_eating/drinking_beha	0.74018595
92	MP0010307_abnormal_tumor_latency	0.73303955
93	MP0003938_abnormal_ear_development	0.72799991
94	MP0003959_abnormal_lean_body	0.71710435
95	MP0005167_abnormal_blood-brain_barrier	0.70870064
96	MP0001119_abnormal_female_reproductive	0.70853460
97	MP0002272_abnormal_nervous_system	0.70538160
98	MP0002734_abnormal_mechanical_nocicepti	0.70470071
99	MP0000778_abnormal_nervous_system	0.69184128
100	MP0000427_abnormal_hair_cycle	0.67415622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.20964140
2	Abnormality of alanine metabolism (HP:0010916)	7.20964140
3	Hyperalaninemia (HP:0003348)	7.20964140
4	3-Methylglutaconic aciduria (HP:0003535)	4.11916664
5	Hyperglycinemia (HP:0002154)	4.06331605
6	Congenital sensorineural hearing impairment (HP:0008527)	3.98940319
7	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.55060072
8	Congenital, generalized hypertrichosis (HP:0004540)	3.51322512
9	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.45502214
10	Abnormality of serum amino acid levels (HP:0003112)	3.42855151
11	Constricted visual fields (HP:0001133)	3.41670013
12	Chromsome breakage (HP:0040012)	3.25873090
13	Toxemia of pregnancy (HP:0100603)	3.22240014
14	Abnormality of the renal collecting system (HP:0004742)	3.17932044
15	Ectopic kidney (HP:0000086)	3.12488259
16	Pendular nystagmus (HP:0012043)	3.07128919
17	Renal cortical cysts (HP:0000803)	3.05768272
18	Abnormality of the fetal cardiovascular system (HP:0010948)	2.93015461
19	Abnormal umbilical cord blood vessels (HP:0011403)	2.93015461
20	Single umbilical artery (HP:0001195)	2.93015461
21	Generalized aminoaciduria (HP:0002909)	2.91183226
22	Duplicated collecting system (HP:0000081)	2.76890991
23	Chorioretinal atrophy (HP:0000533)	2.73172130
24	Abnormality of the renal cortex (HP:0011035)	2.67371760
25	Methylmalonic acidemia (HP:0002912)	2.62153750
26	Palpebral edema (HP:0100540)	2.61186983
27	Birth length less than 3rd percentile (HP:0003561)	2.59421317
28	Maternal diabetes (HP:0009800)	2.49950994
29	Patchy hypopigmentation of hair (HP:0011365)	2.47614497
30	Reduced subcutaneous adipose tissue (HP:0003758)	2.46738644
31	Poor speech (HP:0002465)	2.38327366
32	Insulin-resistant diabetes mellitus (HP:0000831)	2.36118831
33	Abnormality of the labia minora (HP:0012880)	2.33891353
34	Symptomatic seizures (HP:0011145)	2.31638558
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.27169556
36	Abnormality of the umbilical cord (HP:0010881)	2.26604526
37	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25725663
38	Action tremor (HP:0002345)	2.18023939
39	Esophageal varix (HP:0002040)	2.16071345
40	Adrenal hypoplasia (HP:0000835)	2.15557085
41	Homocystinuria (HP:0002156)	2.13256321
42	Abnormality of homocysteine metabolism (HP:0010919)	2.13256321
43	Abnormality of cochlea (HP:0000375)	2.09501201
44	B lymphocytopenia (HP:0010976)	2.08137673
45	White forelock (HP:0002211)	2.07918428
46	Absent phalangeal crease (HP:0006109)	2.07124448
47	Abnormality of glycine metabolism (HP:0010895)	1.99760458
48	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99760458
49	Supernumerary bones of the axial skeleton (HP:0009144)	1.99710286
50	Oligomenorrhea (HP:0000876)	1.99662926
51	Pancytopenia (HP:0001876)	1.97099923
52	Attenuation of retinal blood vessels (HP:0007843)	1.96926150
53	Increased serum lactate (HP:0002151)	1.96640770
54	Decreased subcutaneous fat (HP:0001002)	1.96269144
55	Small hand (HP:0200055)	1.96012092
56	Reticulocytopenia (HP:0001896)	1.95505162
57	Anencephaly (HP:0002323)	1.94793691
58	Nausea (HP:0002018)	1.94435196
59	Pigmentary retinal degeneration (HP:0001146)	1.93758500
60	Methylmalonic aciduria (HP:0012120)	1.92387642
61	Severe Myopia (HP:0011003)	1.91571399
62	Hyperglycemia (HP:0003074)	1.90443732
63	Metabolic acidosis (HP:0001942)	1.90220919
64	Aplastic anemia (HP:0001915)	1.86807609
65	Abnormality of the phalanges of the hallux (HP:0010057)	1.85224614
66	Ulnar deviation of the wrist (HP:0003049)	1.84973293
67	Acute encephalopathy (HP:0006846)	1.83802044
68	Myopathic facies (HP:0002058)	1.83068455
69	Arteriovenous malformation (HP:0100026)	1.82892014
70	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.82229866
71	Molar tooth sign on MRI (HP:0002419)	1.81333256
72	Abnormality of midbrain morphology (HP:0002418)	1.81333256
73	Hepatic necrosis (HP:0002605)	1.81280608
74	True hermaphroditism (HP:0010459)	1.80909741
75	Proximal tubulopathy (HP:0000114)	1.79382378
76	Abnormality of DNA repair (HP:0003254)	1.79120858
77	Short thumb (HP:0009778)	1.77646318
78	Polydipsia (HP:0001959)	1.77032553
79	Abnormal drinking behavior (HP:0030082)	1.77032553
80	Meckel diverticulum (HP:0002245)	1.76913395
81	Horseshoe kidney (HP:0000085)	1.75649930
82	Hypoalphalipoproteinemia (HP:0003233)	1.72679804
83	Abnormal finger flexion creases (HP:0006143)	1.70690387
84	Abnormality of subcutaneous fat tissue (HP:0001001)	1.70202189
85	Abnormal number of incisors (HP:0011064)	1.69551284
86	Abnormality of the ileum (HP:0001549)	1.68621823
87	Optic nerve coloboma (HP:0000588)	1.68457485
88	Lactic acidosis (HP:0003128)	1.67100964
89	Mitochondrial inheritance (HP:0001427)	1.66987746
90	Conjunctival telangiectasia (HP:0000524)	1.65529266
91	Abnormality of B cell number (HP:0010975)	1.62777168
92	Dyskinesia (HP:0100660)	1.62700501
93	Hepatocellular necrosis (HP:0001404)	1.62470570
94	Down-sloping shoulders (HP:0200021)	1.61676118
95	Abnormality of the nasal septum (HP:0000419)	1.61396840
96	Calcaneovalgus deformity (HP:0001848)	1.61260122
97	Abnormality of the 4th metacarpal (HP:0010012)	1.60693507
98	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.60384970
99	Spontaneous hematomas (HP:0007420)	1.59716831
100	Pancreatic cysts (HP:0001737)	1.59412473

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	2.81634386
2	TNIK	2.65635162
3	TXK	2.61608924
4	FRK	2.54726418
5	PHKG1	2.52408048
6	PHKG2	2.52408048
7	TYRO3	2.19591820
8	CASK	2.17802919
9	DYRK2	1.99925321
10	TIE1	1.91747831
11	MAP4K1	1.85751020
12	TSSK6	1.85694285
13	STK16	1.75113597
14	NTRK2	1.75034116
15	WNK4	1.74834871
16	TAF1	1.73729549
17	MAP3K3	1.71516414
18	MAP4K2	1.69523730
19	OBSCN	1.64756258
20	BRSK2	1.63489153
21	MAP2K7	1.55859206
22	SGK494	1.40203122
23	SGK223	1.40203122
24	MAP2K3	1.38510688
25	CDK9	1.29110175
26	TLK1	1.28982031
27	NUAK1	1.28489034
28	EIF2AK1	1.28062851
29	AURKA	1.20559877
30	SCYL2	1.19272285
31	VRK2	1.16977130
32	ACVR1B	1.15888424
33	ADRBK2	1.11071899
34	GRK1	1.08995310
35	CSNK1G2	1.08507666
36	EIF2AK3	1.08440498
37	PIK3CA	1.07326676
38	BUB1	1.06916929
39	PLK4	1.06220597
40	WEE1	1.05706961
41	CCNB1	1.05355642
42	FGFR2	1.04256390
43	JAK3	1.03550431
44	PLK3	1.03103065
45	MAP3K11	1.00310477
46	PNCK	1.00259754
47	BCR	0.99289226
48	CHEK2	0.97532082
49	MAPK13	0.96368518
50	TEC	0.93323712
51	CSNK1G1	0.91417199
52	MARK3	0.89417621
53	SGK2	0.88858337
54	RPS6KB2	0.86320003
55	ADRBK1	0.85216876
56	CSNK1G3	0.84933507
57	FGR	0.84877403
58	WNK3	0.83247189
59	ATR	0.82807040
60	MAP3K4	0.81253658
61	PLK2	0.81125113
62	DMPK	0.80699301
63	NTRK3	0.78445729
64	PLK1	0.78051636
65	STK39	0.77794267
66	ZAK	0.75230530
67	ERBB2	0.75029741
68	FES	0.74776202
69	TESK2	0.73925968
70	CAMK1	0.72108881
71	SRPK1	0.72042375
72	CAMKK2	0.71655422
73	NME2	0.71624223
74	DYRK1B	0.69170593
75	PKN1	0.67096500
76	EPHA4	0.65103307
77	CSNK1A1L	0.64782196
78	MAPK15	0.64756702
79	CDC7	0.64569509
80	EIF2AK2	0.64216198
81	MST4	0.63824117
82	CSNK1A1	0.61264676
83	OXSR1	0.55900699
84	BMPR1B	0.55675855
85	PTK6	0.54565976
86	CAMK1D	0.53671258
87	TTK	0.53250799
88	EPHA3	0.52594290
89	PAK3	0.52152584
90	CSNK2A1	0.50691268
91	PRKCE	0.50386341
92	VRK1	0.49723702
93	RPS6KA4	0.48882614
94	MKNK2	0.46666071
95	BRSK1	0.45908279
96	INSRR	0.45376590
97	PRKACA	0.42167019
98	MINK1	0.41659689
99	DAPK2	0.41425527
100	CAMK2G	0.39894703

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.60869582
2	Proteasome_Homo sapiens_hsa03050	2.83185041
3	Sulfur relay system_Homo sapiens_hsa04122	2.81864315
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.54184859
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40064023
6	Homologous recombination_Homo sapiens_hsa03440	2.34083951
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23273162
8	DNA replication_Homo sapiens_hsa03030	2.14181658
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12660959
10	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.09688544
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.04150330
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99764854
13	Mismatch repair_Homo sapiens_hsa03430	1.98698565
14	Ribosome_Homo sapiens_hsa03010	1.97097424
15	Regulation of autophagy_Homo sapiens_hsa04140	1.94204547
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.90956983
17	RNA degradation_Homo sapiens_hsa03018	1.88671216
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.88007322
19	Folate biosynthesis_Homo sapiens_hsa00790	1.82925726
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.82912948
21	Parkinsons disease_Homo sapiens_hsa05012	1.81990633
22	Sulfur metabolism_Homo sapiens_hsa00920	1.81945760
23	RNA polymerase_Homo sapiens_hsa03020	1.80247112
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.68283772
25	Spliceosome_Homo sapiens_hsa03040	1.67350508
26	Basal transcription factors_Homo sapiens_hsa03022	1.62134149
27	GABAergic synapse_Homo sapiens_hsa04727	1.61326023
28	Morphine addiction_Homo sapiens_hsa05032	1.56786015
29	Base excision repair_Homo sapiens_hsa03410	1.49285029
30	Galactose metabolism_Homo sapiens_hsa00052	1.39069000
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36983416
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.35332428
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.33183689
34	Huntingtons disease_Homo sapiens_hsa05016	1.31978513
35	Nicotine addiction_Homo sapiens_hsa05033	1.31750532
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.28061785
37	Arginine biosynthesis_Homo sapiens_hsa00220	1.26356968
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23663584
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.21319078
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.15386933
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09313176
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04958863
43	Purine metabolism_Homo sapiens_hsa00230	1.04894668
44	Phototransduction_Homo sapiens_hsa04744	1.03439420
45	Alzheimers disease_Homo sapiens_hsa05010	0.98538560
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97109129
47	Serotonergic synapse_Homo sapiens_hsa04726	0.95941309
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.95898804
49	RNA transport_Homo sapiens_hsa03013	0.95032507
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94773259
51	Protein export_Homo sapiens_hsa03060	0.93519369
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92340260
53	Glutathione metabolism_Homo sapiens_hsa00480	0.88879976
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.87414116
55	Circadian entrainment_Homo sapiens_hsa04713	0.84187852
56	Peroxisome_Homo sapiens_hsa04146	0.83945626
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.81459057
58	Olfactory transduction_Homo sapiens_hsa04740	0.81093238
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78951449
60	Propanoate metabolism_Homo sapiens_hsa00640	0.76968685
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76665948
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.75792400
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.75571641
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.74351927
65	Metabolic pathways_Homo sapiens_hsa01100	0.71311376
66	Taste transduction_Homo sapiens_hsa04742	0.71292384
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71200711
68	Fatty acid elongation_Homo sapiens_hsa00062	0.68971261
69	Butanoate metabolism_Homo sapiens_hsa00650	0.64124917
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63136851
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62307322
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62297947
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61738237
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61446543
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.61371279
76	Tight junction_Homo sapiens_hsa04530	0.59690548
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58642775
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.57865498
79	Retinol metabolism_Homo sapiens_hsa00830	0.54711045
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54111890
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.52871841
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.52364501
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50163539
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48382506
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47765320
86	Alcoholism_Homo sapiens_hsa05034	0.46150175
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46120318
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44403320
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43253862
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.41711843
91	Cholinergic synapse_Homo sapiens_hsa04725	0.41041903
92	Caffeine metabolism_Homo sapiens_hsa00232	0.40770619
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40334623
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38871320
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.38836366
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37530524
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.36809243
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36329980
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32525638
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.30385714

EIF5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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