ELAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67298418
2synaptic vesicle maturation (GO:0016188)5.40398527
3synaptic vesicle exocytosis (GO:0016079)5.15982219
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.94024203
5glutamate secretion (GO:0014047)4.80980719
6locomotory exploration behavior (GO:0035641)4.79613255
7regulation of synaptic vesicle exocytosis (GO:2000300)4.78572292
8DNA deamination (GO:0045006)4.76721922
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72159455
10vocalization behavior (GO:0071625)4.67509630
11DNA double-strand break processing (GO:0000729)4.66329340
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.64882834
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56682179
14regulation of glutamate receptor signaling pathway (GO:1900449)4.42447327
15neurotransmitter secretion (GO:0007269)4.41703848
16regulation of synaptic vesicle transport (GO:1902803)4.24852928
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22549035
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.15326405
19activation of protein kinase A activity (GO:0034199)4.15204144
20protein deneddylation (GO:0000338)4.12409377
21gamma-aminobutyric acid transport (GO:0015812)4.10518823
22cellular potassium ion homeostasis (GO:0030007)4.09419300
23cullin deneddylation (GO:0010388)4.09354455
24protein localization to synapse (GO:0035418)3.98481284
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.86403967
26response to pheromone (GO:0019236)3.81385167
27neuronal action potential propagation (GO:0019227)3.79515098
28proline transport (GO:0015824)3.78260921
29sodium ion export (GO:0071436)3.71884352
30peptidyl-histidine modification (GO:0018202)3.71763293
31respiratory chain complex IV assembly (GO:0008535)3.65456977
32regulation of synapse structural plasticity (GO:0051823)3.64848127
33exploration behavior (GO:0035640)3.64748178
34protein K11-linked deubiquitination (GO:0035871)3.63314402
35neurotransmitter-gated ion channel clustering (GO:0072578)3.62472751
36mannosylation (GO:0097502)3.61970662
37neurotransmitter transport (GO:0006836)3.60328993
38positive regulation of synapse maturation (GO:0090129)3.59124893
39regulation of neuronal synaptic plasticity (GO:0048168)3.59015492
40piRNA metabolic process (GO:0034587)3.58202229
41water-soluble vitamin biosynthetic process (GO:0042364)3.57826140
42proteasome assembly (GO:0043248)3.57243968
43neuron cell-cell adhesion (GO:0007158)3.53350095
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50243078
45layer formation in cerebral cortex (GO:0021819)3.46185795
46protein complex biogenesis (GO:0070271)3.45117486
47platelet dense granule organization (GO:0060155)3.44106972
48synaptic transmission, glutamatergic (GO:0035249)3.42501291
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41038752
50glutamate receptor signaling pathway (GO:0007215)3.40090373
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39741053
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39481918
53regulation of neurotransmitter levels (GO:0001505)3.39305564
54neuromuscular process controlling posture (GO:0050884)3.38870738
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37674101
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.37674101
57NADH dehydrogenase complex assembly (GO:0010257)3.37674101
58cerebellar Purkinje cell differentiation (GO:0021702)3.37640454
59synapsis (GO:0007129)3.36806414
60long-term memory (GO:0007616)3.33997792
61neuron-neuron synaptic transmission (GO:0007270)3.33882739
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32015763
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31794481
64mitochondrial respiratory chain complex assembly (GO:0033108)3.31465165
65positive regulation of membrane potential (GO:0045838)3.30323085
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27796488
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21156925
68histone H2A acetylation (GO:0043968)3.20404063
69ketone body metabolic process (GO:1902224)3.19358887
70vesicle transport along microtubule (GO:0047496)3.18943079
71cytochrome complex assembly (GO:0017004)3.16288045
72regulation of postsynaptic membrane potential (GO:0060078)3.14186316
73long-term synaptic potentiation (GO:0060291)3.13636177
74anterograde synaptic vesicle transport (GO:0048490)3.12698459
75replication fork processing (GO:0031297)3.11748741
76iron-sulfur cluster assembly (GO:0016226)3.11610692
77metallo-sulfur cluster assembly (GO:0031163)3.11610692
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.10409663
79DNA catabolic process, exonucleolytic (GO:0000738)3.09197191
80nonmotile primary cilium assembly (GO:0035058)3.09086179
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08437947
82preassembly of GPI anchor in ER membrane (GO:0016254)3.07992817
83neural tube formation (GO:0001841)3.07373519
84potassium ion import (GO:0010107)3.06347330
85regulation of glucokinase activity (GO:0033131)3.05655440
86regulation of hexokinase activity (GO:1903299)3.05655440
87ubiquinone biosynthetic process (GO:0006744)3.05413400
88regulation of ARF protein signal transduction (GO:0032012)3.05133696
89response to histamine (GO:0034776)3.04365647
90base-excision repair, AP site formation (GO:0006285)3.02382992
91cellular ketone body metabolic process (GO:0046950)3.02201112
92regulation of cilium movement (GO:0003352)3.01752855
93alanine transport (GO:0032328)3.01573898
94synaptic vesicle endocytosis (GO:0048488)3.01339823
95ubiquinone metabolic process (GO:0006743)3.00208071
96neuromuscular process controlling balance (GO:0050885)2.98632853
97L-fucose metabolic process (GO:0042354)2.98040416
98L-fucose catabolic process (GO:0042355)2.98040416
99fucose catabolic process (GO:0019317)2.98040416
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96824959
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.95811044
102membrane depolarization during action potential (GO:0086010)2.95363574
103regulation of synaptic plasticity (GO:0048167)2.93749490
104protein neddylation (GO:0045116)2.92923540
105lactate metabolic process (GO:0006089)2.91686090
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91156763
107protein polyglutamylation (GO:0018095)2.90904487
108C-terminal protein lipidation (GO:0006501)2.89246619
109positive regulation of potassium ion transmembrane transport (GO:1901381)2.88714309
110regulation of neurotransmitter secretion (GO:0046928)2.88571029
111regulation of vesicle fusion (GO:0031338)2.87351191
112retinal cone cell development (GO:0046549)2.87333015
113intraciliary transport (GO:0042073)2.85336946
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.85099470
115L-methionine salvage (GO:0071267)2.84282630
116L-methionine biosynthetic process (GO:0071265)2.84282630
117amino acid salvage (GO:0043102)2.84282630
118rRNA modification (GO:0000154)2.82730411
119S-adenosylmethionine metabolic process (GO:0046500)2.81772138
120potassium ion homeostasis (GO:0055075)2.81426826
121transmission of nerve impulse (GO:0019226)2.80647124
122signal peptide processing (GO:0006465)2.80446466
123membrane depolarization (GO:0051899)2.80215284
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80147504
125recombinational repair (GO:0000725)2.80098557
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79976250
127protein prenylation (GO:0018342)2.79570669
128prenylation (GO:0097354)2.79570669
129double-strand break repair via homologous recombination (GO:0000724)2.78977904
130positive regulation of synaptic transmission (GO:0050806)2.77993493
131glycine transport (GO:0015816)2.77944841
132regulation of clathrin-mediated endocytosis (GO:2000369)2.77078653
133reciprocal DNA recombination (GO:0035825)2.76956108
134reciprocal meiotic recombination (GO:0007131)2.76956108
135mating behavior (GO:0007617)2.76676010
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76109255
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75799561
138positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75000044
139protein-cofactor linkage (GO:0018065)2.74352966
140chaperone-mediated protein transport (GO:0072321)2.73959566
141cellular sodium ion homeostasis (GO:0006883)2.73661816
142rRNA methylation (GO:0031167)2.73198777
143pyrimidine nucleobase catabolic process (GO:0006208)2.73002983
144C-terminal protein amino acid modification (GO:0018410)2.71602163
145indolalkylamine metabolic process (GO:0006586)2.71111832
146cell communication by electrical coupling (GO:0010644)2.70650659
147positive regulation of neurotransmitter transport (GO:0051590)2.68666663
148regulation of neurotransmitter transport (GO:0051588)2.68158498
149GPI anchor metabolic process (GO:0006505)2.67675134
150membrane hyperpolarization (GO:0060081)2.67466849
151cerebellar Purkinje cell layer development (GO:0021680)2.66892339
152organelle transport along microtubule (GO:0072384)2.66811605
153cerebellar granule cell differentiation (GO:0021707)2.66601052
154organelle disassembly (GO:1903008)2.65440375
155synaptic transmission (GO:0007268)2.65255670
156dopamine transport (GO:0015872)2.65209915
157intraspecies interaction between organisms (GO:0051703)2.65152307
158social behavior (GO:0035176)2.65152307
159pseudouridine synthesis (GO:0001522)2.63450744
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.63229891
161cilium morphogenesis (GO:0060271)2.62723573
162negative regulation of telomere maintenance (GO:0032205)2.62602401
163regulation of synapse maturation (GO:0090128)2.61897704
164RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61616018
165protein K6-linked ubiquitination (GO:0085020)2.61088830
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61072372
167DNA methylation involved in gamete generation (GO:0043046)2.60904841
168regulation of beta-amyloid formation (GO:1902003)2.60558488
169cilium organization (GO:0044782)2.59901169
170prepulse inhibition (GO:0060134)2.59195242
171response to auditory stimulus (GO:0010996)2.59106637
172behavioral response to cocaine (GO:0048148)2.59075805
173termination of RNA polymerase III transcription (GO:0006386)2.58275071
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.58275071
175somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58231223
176somatic hypermutation of immunoglobulin genes (GO:0016446)2.58231223
177detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57678387
178regulation of synaptic transmission (GO:0050804)2.57587323
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57243910
180regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57130328
181auditory behavior (GO:0031223)2.56955321
182positive regulation of mitochondrial fission (GO:0090141)2.56839798
183neuromuscular process (GO:0050905)2.55983465
184suckling behavior (GO:0001967)2.55917133
185synapse assembly (GO:0007416)2.55513386
186mismatch repair (GO:0006298)2.55218582
187dicarboxylic acid biosynthetic process (GO:0043650)2.55073850
188cell differentiation in hindbrain (GO:0021533)2.54902201
189epithelial cilium movement (GO:0003351)2.54764872
190male meiosis I (GO:0007141)2.54544184
191cilium assembly (GO:0042384)2.54115211
192protein localization to cilium (GO:0061512)2.54039449
193GPI anchor biosynthetic process (GO:0006506)2.52494387
194postreplication repair (GO:0006301)2.49213952
195resolution of meiotic recombination intermediates (GO:0000712)2.49148742
196nucleotide transmembrane transport (GO:1901679)2.48284518
197RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47741146
198tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47741146
199ribonucleoprotein complex disassembly (GO:0032988)2.46118114
200mitochondrial RNA metabolic process (GO:0000959)2.45281777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76675707
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67881927
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.64784910
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.45489045
5IGF1R_20145208_ChIP-Seq_DFB_Human3.02151207
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.98294740
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90055883
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78467258
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77008842
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72657562
11GBX2_23144817_ChIP-Seq_PC3_Human2.71972405
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.63087942
13DROSHA_22980978_ChIP-Seq_HELA_Human2.62022291
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57259552
15REST_21632747_ChIP-Seq_MESCs_Mouse2.54539336
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45595385
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41272016
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38912238
19VDR_23849224_ChIP-Seq_CD4+_Human2.37201999
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.32554570
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30144524
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24652436
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24652436
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.24546174
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23807326
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20824945
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20298723
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17938966
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.17641689
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17397366
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15933091
32FUS_26573619_Chip-Seq_HEK293_Human2.14207250
33ELK1_19687146_ChIP-ChIP_HELA_Human2.13140295
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12491532
35ETS1_20019798_ChIP-Seq_JURKAT_Human2.09186970
36SALL1_21062744_ChIP-ChIP_HESCs_Human2.08551029
37FLI1_27457419_Chip-Seq_LIVER_Mouse2.05540766
38EWS_26573619_Chip-Seq_HEK293_Human2.03609795
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98699613
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98041790
41VDR_22108803_ChIP-Seq_LS180_Human1.97752484
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93444893
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.92652537
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92507745
45TAF15_26573619_Chip-Seq_HEK293_Human1.86437258
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.85272170
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84956886
48FOXP3_21729870_ChIP-Seq_TREG_Human1.80289131
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.77875795
50MYC_18940864_ChIP-ChIP_HL60_Human1.75697826
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74328764
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73266251
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72382550
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72093254
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.68591914
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68003952
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65151608
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64795869
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63864174
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.61984394
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60950524
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.60853237
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57284605
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56158616
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55911684
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54127420
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49057683
68DCP1A_22483619_ChIP-Seq_HELA_Human1.45078762
69TP53_22573176_ChIP-Seq_HFKS_Human1.43425243
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42474056
71AR_21572438_ChIP-Seq_LNCaP_Human1.42310794
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41300044
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40916401
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40056778
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39861514
76* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39253739
77IRF1_19129219_ChIP-ChIP_H3396_Human1.37689313
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37360862
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37200458
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36302044
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33269705
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30965321
83* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30794041
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30711535
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30690887
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30500000
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29371762
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.27496295
89* GABP_19822575_ChIP-Seq_HepG2_Human1.27364608
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26705457
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.24849995
92P300_19829295_ChIP-Seq_ESCs_Human1.23467828
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22492638
94* AR_19668381_ChIP-Seq_PC3_Human1.21614521
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21233412
96RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20932737
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19699066
98ZNF274_21170338_ChIP-Seq_K562_Hela1.19461667
99AR_25329375_ChIP-Seq_VCAP_Human1.18477805
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.18286789
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18198147
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17504169
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17500852
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.15939696
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14738181
106KDM2B_26808549_Chip-Seq_K562_Human1.14400927
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12674679
108STAT3_23295773_ChIP-Seq_U87_Human1.12563523
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12437042
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11673264
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10035433
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.10035433
113NANOG_19829295_ChIP-Seq_ESCs_Human1.08724170
114SOX2_19829295_ChIP-Seq_ESCs_Human1.08724170
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.07576798
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07316459
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07279296
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.06934700
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06895117
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06863009
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06200606
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05803721
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05295911
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04900452
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.04503760
126HTT_18923047_ChIP-ChIP_STHdh_Human1.03353586
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02769955
128* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02721601
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02578102
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02164018
131TCF4_23295773_ChIP-Seq_U87_Human1.01896892
132NCOR_22424771_ChIP-Seq_293T_Human1.01717298
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01280415
134TCF4_22108803_ChIP-Seq_LS180_Human1.00933995
135RXR_22108803_ChIP-Seq_LS180_Human0.98882266
136BCAT_22108803_ChIP-Seq_LS180_Human0.98506739
137AHR_22903824_ChIP-Seq_MCF-7_Human0.98167166
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97965103
139RNF2_27304074_Chip-Seq_NSC_Mouse0.97943823
140GATA3_26560356_Chip-Seq_TH2_Human0.97920408
141P53_22387025_ChIP-Seq_ESCs_Mouse0.97810532
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97717721
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97148240
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.97026461
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.96856912
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96336228
147AR_20517297_ChIP-Seq_VCAP_Human0.96254367
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96181591
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94808084
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.94719539
151TP53_16413492_ChIP-PET_HCT116_Human0.94607549
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.94577225
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94457487
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94241375
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93704584
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93254192
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93076140
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92639977
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91550148
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90133638
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90129639
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.88288326
163KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88123741
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87715923
165NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87517963
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85967041
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.85804819
168FLI1_21867929_ChIP-Seq_TH2_Mouse0.84783650
169ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84627690
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83978031
171ER_23166858_ChIP-Seq_MCF-7_Human0.82923796
172* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82577725
173FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82374560
174TET1_21490601_ChIP-Seq_MESCs_Mouse0.81654401
175TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80653935
176CBP_20019798_ChIP-Seq_JUKART_Human0.79482343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.59887130
2MP0002102_abnormal_ear_morphology3.96594506
3MP0003635_abnormal_synaptic_transmissio3.88888263
4MP0003880_abnormal_central_pattern3.78633985
5MP0009046_muscle_twitch3.32537803
6MP0008877_abnormal_DNA_methylation3.24821240
7MP0002064_seizures3.17072404
8MP0009745_abnormal_behavioral_response3.13713863
9MP0000372_irregular_coat_pigmentation3.02277479
10MP0004270_analgesia2.91055013
11MP0002063_abnormal_learning/memory/cond2.88547185
12MP0001968_abnormal_touch/_nociception2.69599565
13MP0002572_abnormal_emotion/affect_behav2.51125658
14MP0008058_abnormal_DNA_repair2.45784867
15MP0002822_catalepsy2.45156174
16MP0003195_calcinosis2.43888434
17MP0001501_abnormal_sleep_pattern2.41685793
18MP0002272_abnormal_nervous_system2.39394228
19MP0002909_abnormal_adrenal_gland2.30767824
20MP0005423_abnormal_somatic_nervous2.21220599
21MP0001486_abnormal_startle_reflex2.10126275
22MP0003786_premature_aging2.00688084
23MP0002736_abnormal_nociception_after2.00633579
24MP0003329_amyloid_beta_deposits1.98866746
25MP0008995_early_reproductive_senescence1.96546006
26MP0002734_abnormal_mechanical_nocicepti1.95707715
27MP0001440_abnormal_grooming_behavior1.88527372
28MP0002837_dystrophic_cardiac_calcinosis1.88493911
29MP0002067_abnormal_sensory_capabilities1.87708561
30MP0008569_lethality_at_weaning1.87443236
31MP0005646_abnormal_pituitary_gland1.84678746
32MP0008789_abnormal_olfactory_epithelium1.82289224
33MP0002735_abnormal_chemical_nociception1.81136173
34MP0002733_abnormal_thermal_nociception1.79486833
35MP0004147_increased_porphyrin_level1.76473396
36MP0002638_abnormal_pupillary_reflex1.76358562
37MP0001970_abnormal_pain_threshold1.74875164
38MP0005075_abnormal_melanosome_morpholog1.73240905
39MP0010094_abnormal_chromosome_stability1.72850675
40MP0003787_abnormal_imprinting1.72642992
41MP0002653_abnormal_ependyma_morphology1.70874175
42MP0009697_abnormal_copulation1.70725336
43MP0009780_abnormal_chondrocyte_physiolo1.69755565
44MP0003633_abnormal_nervous_system1.67558222
45MP0005386_behavior/neurological_phenoty1.66951805
46MP0004924_abnormal_behavior1.66951805
47MP0003186_abnormal_redox_activity1.66885364
48MP0005551_abnormal_eye_electrophysiolog1.66008575
49MP0003718_maternal_effect1.64901453
50MP0004133_heterotaxia1.63373751
51MP0000013_abnormal_adipose_tissue1.52551275
52MP0002557_abnormal_social/conspecific_i1.51301560
53MP0003172_abnormal_lysosome_physiology1.49709575
54MP0004811_abnormal_neuron_physiology1.49684385
55MP0002095_abnormal_skin_pigmentation1.48895271
56MP0000427_abnormal_hair_cycle1.48012508
57MP0005379_endocrine/exocrine_gland_phen1.43729289
58MP0000751_myopathy1.43321488
59MP0001502_abnormal_circadian_rhythm1.42535009
60MP0001764_abnormal_homeostasis1.42264111
61MP0008057_abnormal_DNA_replication1.41822903
62MP0006036_abnormal_mitochondrial_physio1.41241283
63MP0005394_taste/olfaction_phenotype1.39529903
64MP0005499_abnormal_olfactory_system1.39529903
65MP0006276_abnormal_autonomic_nervous1.39031663
66MP0002090_abnormal_vision1.38656232
67MP0004130_abnormal_muscle_cell1.38232467
68MP0000604_amyloidosis1.37732584
69MP0002163_abnormal_gland_morphology1.37500284
70MP0004145_abnormal_muscle_electrophysio1.37069217
71MP0001919_abnormal_reproductive_system1.36693147
72MP0003879_abnormal_hair_cell1.36359046
73MP0004858_abnormal_nervous_system1.36105314
74MP0003122_maternal_imprinting1.35342238
75MP0003690_abnormal_glial_cell1.33141214
76MP0002184_abnormal_innervation1.32670430
77MP0000015_abnormal_ear_pigmentation1.32160318
78MP0005389_reproductive_system_phenotype1.31742310
79MP0002751_abnormal_autonomic_nervous1.29996370
80MP0003646_muscle_fatigue1.28757238
81MP0006292_abnormal_olfactory_placode1.27092272
82MP0008874_decreased_physiological_sensi1.26116671
83MP0002066_abnormal_motor_capabilities/c1.25947285
84MP0002229_neurodegeneration1.24300965
85MP0003631_nervous_system_phenotype1.23147530
86MP0001929_abnormal_gametogenesis1.22551572
87MP0001984_abnormal_olfaction1.22026852
88MP0003137_abnormal_impulse_conducting1.20993747
89MP0001986_abnormal_taste_sensitivity1.20084807
90MP0002210_abnormal_sex_determination1.18762478
91MP0005535_abnormal_body_temperature1.18043838
92MP0005167_abnormal_blood-brain_barrier1.17898972
93MP0000747_muscle_weakness1.17885032
94MP0003011_delayed_dark_adaptation1.17037444
95MP0000955_abnormal_spinal_cord1.15810387
96MP0008872_abnormal_physiological_respon1.15578362
97MP0003252_abnormal_bile_duct1.14671934
98MP0008961_abnormal_basal_metabolism1.13367796
99MP0002882_abnormal_neuron_morphology1.12560667
100MP0005332_abnormal_amino_acid1.11155853
101MP0002876_abnormal_thyroid_physiology1.10588460
102MP0004142_abnormal_muscle_tone1.08012037
103MP0003806_abnormal_nucleotide_metabolis1.07110314
104MP0003698_abnormal_male_reproductive1.06151978
105MP0003075_altered_response_to1.04070949
106MP0010329_abnormal_lipoprotein_level1.02839221
107MP0000631_abnormal_neuroendocrine_gland1.00896248
108MP0003121_genomic_imprinting1.00842869
109MP0005645_abnormal_hypothalamus_physiol1.00318387
110MP0000653_abnormal_sex_gland1.00039822
111MP0006035_abnormal_mitochondrial_morpho0.98962819
112MP0004215_abnormal_myocardial_fiber0.98727563
113MP0000569_abnormal_digit_pigmentation0.98496969
114MP0005360_urolithiasis0.98112569
115MP0001145_abnormal_male_reproductive0.97626104
116MP0002139_abnormal_hepatobiliary_system0.97533750
117MP0002234_abnormal_pharynx_morphology0.96333780
118MP0001324_abnormal_eye_pigmentation0.95206132
119MP0005365_abnormal_bile_salt0.94776513
120MP0004885_abnormal_endolymph0.93006478
121MP0005058_abnormal_lysosome_morphology0.92405435
122MP0002938_white_spotting0.92205397
123MP0002069_abnormal_eating/drinking_beha0.92137406
124MP0005408_hypopigmentation0.90876234
125MP0005410_abnormal_fertilization0.90311704
126MP0005174_abnormal_tail_pigmentation0.89371390
127MP0005084_abnormal_gallbladder_morpholo0.89260405
128MP0001119_abnormal_female_reproductive0.88469172
129MP0005220_abnormal_exocrine_pancreas0.88144519
130MP0000371_diluted_coat_color0.87885038
131MP0003183_abnormal_peptide_metabolism0.87529761
132MP0000516_abnormal_urinary_system0.86966873
133MP0005367_renal/urinary_system_phenotyp0.86966873
134MP0000647_abnormal_sebaceous_gland0.85594943
135MP0005085_abnormal_gallbladder_physiolo0.85259999
136MP0005636_abnormal_mineral_homeostasis0.84257398
137MP0004036_abnormal_muscle_relaxation0.84190419
138MP0004085_abnormal_heartbeat0.84127747
139MP0003303_peritoneal_inflammation0.83124308
140MP0006072_abnormal_retinal_apoptosis0.82464756
141MP0008875_abnormal_xenobiotic_pharmacok0.81879688
142MP0010234_abnormal_vibrissa_follicle0.79847694
143MP0003567_abnormal_fetal_cardiomyocyte0.79302426
144MP0004043_abnormal_pH_regulation0.79113088
145MP0003634_abnormal_glial_cell0.78603604
146MP0000778_abnormal_nervous_system0.77216744
147MP0005195_abnormal_posterior_eye0.76554972
148MP0002078_abnormal_glucose_homeostasis0.76048208
149MP0001905_abnormal_dopamine_level0.75357052
150MP0002928_abnormal_bile_duct0.75341855
151MP0005584_abnormal_enzyme/coenzyme_acti0.75223169
152MP0000920_abnormal_myelination0.75067439
153MP0002160_abnormal_reproductive_system0.74979863
154MP0005171_absent_coat_pigmentation0.74749740
155MP0003221_abnormal_cardiomyocyte_apopto0.74002004
156MP0002152_abnormal_brain_morphology0.73976393
157MP0005448_abnormal_energy_balance0.73161776
158MP0005253_abnormal_eye_physiology0.72041019
159MP0009764_decreased_sensitivity_to0.71522953
160MP0001177_atelectasis0.69746130
161MP0002118_abnormal_lipid_homeostasis0.68913692
162MP0005187_abnormal_penis_morphology0.66709666
163MP0001765_abnormal_ion_homeostasis0.65676886
164MP0005083_abnormal_biliary_tract0.65629443
165MP0003632_abnormal_nervous_system0.65041391
166MP0003045_fibrosis0.64199997
167MP0001529_abnormal_vocalization0.62364076
168MP0010386_abnormal_urinary_bladder0.61717031

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51776132
2Myokymia (HP:0002411)5.37839954
3Visual hallucinations (HP:0002367)5.27301438
4Focal seizures (HP:0007359)4.85199159
5Atonic seizures (HP:0010819)4.44303227
6Absence seizures (HP:0002121)4.14081509
7Epileptic encephalopathy (HP:0200134)4.04889450
8Febrile seizures (HP:0002373)3.91483954
9Generalized tonic-clonic seizures (HP:0002069)3.86020184
10Dialeptic seizures (HP:0011146)3.77966961
11Acute necrotizing encephalopathy (HP:0006965)3.65707505
12Action tremor (HP:0002345)3.62739302
13Methylmalonic acidemia (HP:0002912)3.52468466
14Medial flaring of the eyebrow (HP:0010747)3.51339064
15Truncal ataxia (HP:0002078)3.45338891
16Supranuclear gaze palsy (HP:0000605)3.41220812
17Progressive cerebellar ataxia (HP:0002073)3.40688060
18Abnormal mitochondria in muscle tissue (HP:0008316)3.36566882
19Depression (HP:0000716)3.36197354
20Papilledema (HP:0001085)3.30215038
21Molar tooth sign on MRI (HP:0002419)3.29589753
22Abnormality of midbrain morphology (HP:0002418)3.29589753
23Pancreatic fibrosis (HP:0100732)3.27492000
24Mitochondrial inheritance (HP:0001427)3.27142376
25Impaired vibration sensation in the lower limbs (HP:0002166)3.23767090
26True hermaphroditism (HP:0010459)3.22511967
27Increased CSF lactate (HP:0002490)3.22278149
28Acute encephalopathy (HP:0006846)3.20793798
29Progressive macrocephaly (HP:0004481)3.18444342
30Methylmalonic aciduria (HP:0012120)3.18091973
31Hepatic necrosis (HP:0002605)3.16019199
32Pancreatic cysts (HP:0001737)3.14035526
33Hyperventilation (HP:0002883)3.13866295
34Mutism (HP:0002300)3.09686710
35Renal cortical cysts (HP:0000803)3.08529840
36Hepatocellular necrosis (HP:0001404)3.07944050
37Postural instability (HP:0002172)3.07361173
38Congenital primary aphakia (HP:0007707)3.03784602
39Impaired social interactions (HP:0000735)3.02203869
40Abnormal social behavior (HP:0012433)3.02203869
41Gait imbalance (HP:0002141)3.00270966
423-Methylglutaconic aciduria (HP:0003535)2.99154591
43Hemiplegia (HP:0002301)2.98629263
44Nephronophthisis (HP:0000090)2.97083802
45Anxiety (HP:0000739)2.95253110
46Abnormality of the renal cortex (HP:0011035)2.94087589
47Dysdiadochokinesis (HP:0002075)2.93104331
48Poor eye contact (HP:0000817)2.89138793
49Dysmetric saccades (HP:0000641)2.85090591
50Dysmetria (HP:0001310)2.83365844
51Intestinal atresia (HP:0011100)2.82934180
52Broad-based gait (HP:0002136)2.82718158
53Central scotoma (HP:0000603)2.81254292
54Gaze-evoked nystagmus (HP:0000640)2.80955875
55Ankle clonus (HP:0011448)2.80417701
56Abnormal eating behavior (HP:0100738)2.78407959
57Nephrogenic diabetes insipidus (HP:0009806)2.76864856
58Status epilepticus (HP:0002133)2.75644155
59Hyperglycinemia (HP:0002154)2.74357604
60Pheochromocytoma (HP:0002666)2.64572806
61Abnormality of the lower motor neuron (HP:0002366)2.64036816
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63751446
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61571535
64Abnormality of alanine metabolism (HP:0010916)2.61571535
65Hyperalaninemia (HP:0003348)2.61571535
66Urinary bladder sphincter dysfunction (HP:0002839)2.59154485
67Abnormality of vitamin B metabolism (HP:0004340)2.57802414
68Spastic gait (HP:0002064)2.56995814
69Bradykinesia (HP:0002067)2.56682467
70Tubulointerstitial nephritis (HP:0001970)2.56618784
71Diplopia (HP:0000651)2.54739437
72Abnormality of binocular vision (HP:0011514)2.54739437
73Progressive inability to walk (HP:0002505)2.51471260
74Abnormality of the renal medulla (HP:0100957)2.51286171
75Type II lissencephaly (HP:0007260)2.47068309
76Resting tremor (HP:0002322)2.43274068
77Abnormality of ocular smooth pursuit (HP:0000617)2.42683781
78Type I transferrin isoform profile (HP:0003642)2.41596124
79Increased serum lactate (HP:0002151)2.41521369
80Impaired smooth pursuit (HP:0007772)2.41288414
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.40961901
82Neuronal loss in central nervous system (HP:0002529)2.40453410
83Agitation (HP:0000713)2.39603719
84Excessive salivation (HP:0003781)2.39198920
85Drooling (HP:0002307)2.39198920
86Ventricular fibrillation (HP:0001663)2.38382458
87Chronic hepatic failure (HP:0100626)2.37902702
88Psychosis (HP:0000709)2.37758293
89Lactic acidosis (HP:0003128)2.36750539
90Intention tremor (HP:0002080)2.34706277
91Increased cerebral lipofuscin (HP:0011813)2.33923735
92Abnormality of the vitamin B12 metabolism (HP:0004341)2.32263286
93Respiratory failure (HP:0002878)2.30579810
94Abnormal protein glycosylation (HP:0012346)2.28331692
95Abnormal glycosylation (HP:0012345)2.28331692
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28331692
97Abnormal protein N-linked glycosylation (HP:0012347)2.28331692
98Urinary urgency (HP:0000012)2.27849405
99Stereotypic behavior (HP:0000733)2.27629519
100Neuroendocrine neoplasm (HP:0100634)2.26862392
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25938607
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25938607
103Cerebral edema (HP:0002181)2.25536281
104Short tibia (HP:0005736)2.24854684
105Impaired vibratory sensation (HP:0002495)2.23928822
106Postural tremor (HP:0002174)2.23388262
107Tetraplegia (HP:0002445)2.21828766
108Torticollis (HP:0000473)2.21589030
109Rigidity (HP:0002063)2.21176026
110Focal dystonia (HP:0004373)2.17755815
111Lipid accumulation in hepatocytes (HP:0006561)2.17378128
112Increased hepatocellular lipid droplets (HP:0006565)2.16487072
113Genital tract atresia (HP:0001827)2.16230798
114Retinal dysplasia (HP:0007973)2.12154166
115Exercise-induced myalgia (HP:0003738)2.11007866
116Abnormality of the labia minora (HP:0012880)2.09522721
117Epileptiform EEG discharges (HP:0011182)2.07062230
118Abnormality of serum amino acid levels (HP:0003112)2.06592761
119Cerebral inclusion bodies (HP:0100314)2.05267980
120Generalized myoclonic seizures (HP:0002123)2.04348844
121Hypoplasia of the fovea (HP:0007750)2.03784476
122Aplasia/Hypoplasia of the fovea (HP:0008060)2.03784476
123Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03391440
124Dicarboxylic aciduria (HP:0003215)2.03391440
125Termporal pattern (HP:0011008)2.03333941
126Insidious onset (HP:0003587)2.03333941
127Congenital stationary night blindness (HP:0007642)2.03161374
128Optic disc pallor (HP:0000543)2.02180197
129Lethargy (HP:0001254)2.01228088
130Lower limb muscle weakness (HP:0007340)2.00404456
131Abnormality of saccadic eye movements (HP:0000570)2.00001769
132Scanning speech (HP:0002168)1.99682906
133Craniofacial dystonia (HP:0012179)1.99630372
134Oligomenorrhea (HP:0000876)1.99478439
135Ketoacidosis (HP:0001993)1.99060533
136Vaginal atresia (HP:0000148)1.98244541
137EEG with generalized epileptiform discharges (HP:0011198)1.97874102
138Lissencephaly (HP:0001339)1.96294620
139Amblyopia (HP:0000646)1.96259954
140Neoplasm of the adrenal cortex (HP:0100641)1.95372855
141Abnormality of the anterior horn cell (HP:0006802)1.94206359
142Degeneration of anterior horn cells (HP:0002398)1.94206359
143Polyphagia (HP:0002591)1.92874128
144Aplasia/Hypoplasia of the tongue (HP:0010295)1.92138067
145Gait ataxia (HP:0002066)1.91815435
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.91792199
147Attenuation of retinal blood vessels (HP:0007843)1.91645987
148Blue irides (HP:0000635)1.91136007
149Rapidly progressive (HP:0003678)1.90838149
150Myotonia (HP:0002486)1.90562217
151Hypothermia (HP:0002045)1.90131249
152Global brain atrophy (HP:0002283)1.89768656
153Postaxial hand polydactyly (HP:0001162)1.89470761
154Bile duct proliferation (HP:0001408)1.89029537
155Abnormal biliary tract physiology (HP:0012439)1.89029537
156Annular pancreas (HP:0001734)1.88986570
157Ketosis (HP:0001946)1.88969636
158Abolished electroretinogram (ERG) (HP:0000550)1.88914789
159Increased neuronal autofluorescent lipopigment (HP:0002074)1.87802222
160Colon cancer (HP:0003003)1.87723550
161Clonus (HP:0002169)1.87414913
162Neurofibrillary tangles (HP:0002185)1.87018688
163Macroorchidism (HP:0000053)1.86250894
164Hypsarrhythmia (HP:0002521)1.85958439
165Congenital hepatic fibrosis (HP:0002612)1.85453276
166Genetic anticipation (HP:0003743)1.84901765
167Meckel diverticulum (HP:0002245)1.84719961
168Striae distensae (HP:0001065)1.84650441
169Occipital encephalocele (HP:0002085)1.83364634
170Abnormality of chromosome stability (HP:0003220)1.83203342
171CNS demyelination (HP:0007305)1.82605896
172Retinal atrophy (HP:0001105)1.82140677
173Poor coordination (HP:0002370)1.81422821
174Abnormality of the ileum (HP:0001549)1.80906351
175Postaxial foot polydactyly (HP:0001830)1.79752333
176Cystic liver disease (HP:0006706)1.79525988
177Growth hormone excess (HP:0000845)1.79516112
178Hypoventilation (HP:0002791)1.77978556
179Abnormality of the corticospinal tract (HP:0002492)1.77899348
180Male pseudohermaphroditism (HP:0000037)1.77737627
181Inability to walk (HP:0002540)1.77561555
182Absent speech (HP:0001344)1.77058917
183Abnormality of vitamin metabolism (HP:0100508)1.75945967
184Abnormality of pain sensation (HP:0010832)1.75612098
185Impaired pain sensation (HP:0007328)1.75612098
186Aplasia/hypoplasia of the uterus (HP:0008684)1.74172077
187Congenital sensorineural hearing impairment (HP:0008527)1.73432581
188Abnormality of glycine metabolism (HP:0010895)1.73110632
189Abnormality of serine family amino acid metabolism (HP:0010894)1.73110632
190Spinal canal stenosis (HP:0003416)1.72918085
191Abnormality of the fovea (HP:0000493)1.72652499
192Astigmatism (HP:0000483)1.71953733
193Limb dystonia (HP:0002451)1.71930493
194Menstrual irregularities (HP:0000858)1.71553560
195Tubulointerstitial abnormality (HP:0001969)1.71135497
196Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71027105
197Aganglionic megacolon (HP:0002251)1.70532708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.22821253
2MAP3K43.62393043
3MAP3K93.54476470
4MAP4K23.43894005
5MAP3K123.31661230
6MAP2K43.18179365
7WNK32.92521343
8EPHA42.73516106
9MAP2K72.73228997
10ZAK2.41431047
11EIF2AK32.40115954
12MINK12.38479818
13ERBB32.25931756
14TRIM282.16389227
15BCR2.14002288
16MST42.04089637
17CAMKK12.01537043
18NUAK11.96081923
19RIPK41.95616913
20KSR21.94537914
21FES1.94439653
22DAPK21.92610281
23CSNK1G11.90830818
24GRK11.88586045
25CSNK1G31.87286579
26ACVR1B1.74452393
27CAMKK21.73192728
28CSNK1A1L1.71186626
29BCKDK1.69445761
30PAK61.63208950
31EIF2AK11.62884863
32MARK11.62645129
33MAP3K131.60553091
34CSNK1G21.57347795
35CASK1.56010619
36PRKD31.55148059
37BMPR1B1.53175306
38GRK51.52071982
39PRPF4B1.48653090
40NTRK21.47471071
41BUB11.45447638
42ADRBK21.44782799
43CCNB11.39067108
44SIK21.33049976
45NTRK11.31313139
46DAPK11.29440001
47PRKCH1.28355608
48STK381.27122927
49CDK191.26657829
50TAOK11.25109391
51CDK51.23500653
52RPS6KA41.19654226
53RET1.18692540
54MAP3K21.16828936
55SRPK11.15110198
56VRK11.11523381
57SGK31.08294350
58PINK11.07121133
59MAP3K11.05654843
60LMTK21.04492875
61STK161.03447636
62SGK21.02856919
63TNK21.01972872
64CAMK1G1.00874544
65PLK41.00236265
66PHKG10.99409668
67PHKG20.99409668
68STK390.98063315
69MAPKAPK30.97862220
70PRKCG0.97709310
71DYRK20.97054318
72ARAF0.96077539
73PDK10.94310370
74MAP3K70.93936467
75TAOK30.93774840
76STK110.92563736
77WNK40.91539433
78CAMK10.90802621
79SGK2230.90265731
80SGK4940.90265731
81PLK30.90082809
82INSRR0.89313942
83AKT30.87681850
84CDC70.87299953
85PDPK10.84559494
86KSR10.84501323
87RIPK10.84422032
88ATR0.84323248
89VRK20.83919205
90PLK10.81041780
91TXK0.80958808
92PLK20.79864878
93WEE10.78170245
94SIK30.77620578
95PRKCE0.77303201
96MKNK20.75859534
97PNCK0.75526308
98GRK70.74813945
99CAMK2A0.74027396
100ALK0.73762030
101MKNK10.72289964
102PAK30.67012349
103FER0.66488648
104ATM0.65629011
105CAMK2B0.65368509
106MAP3K60.63644657
107PRKCQ0.62604293
108JAK10.62578801
109MAPK120.62170468
110SGK10.61910208
111KDR0.59732421
112RPS6KA50.59056879
113DYRK30.58727774
114PKN20.58178559
115MAPK130.57817707
116MAPKAPK50.57345893
117UHMK10.55549326
118PDK30.55432402
119PDK40.55432402
120CSNK1A10.55215139
121STK30.54899785
122CAMK40.54437561
123TLK10.54295709
124EIF2AK20.53490996
125TNIK0.53041727
126CAMK2G0.51113485
127TEC0.51033019
128FYN0.50793986
129PTK2B0.50708939
130CAMK2D0.50353037
131RPS6KA30.49736752
132NEK10.49321986
133CHEK20.49087881
134CDK150.48735045
135SCYL20.48584357
136BRSK20.47850550
137JAK20.47834995
138BMPR20.47765028
139CDK180.47752311
140PIM10.47097342
141WNK10.46858220
142MARK30.46487349
143STK38L0.46446291
144MARK20.46176935
145MAP3K110.45783137
146PDK20.45548952
147ADRBK10.45506232
148LIMK10.44573984
149CDK140.44132640
150RAF10.43994174
151IRAK20.43771431
152ABL10.43155006
153IKBKB0.42819531
154FRK0.42412270
155PIM20.42119019
156MAP2K30.40542360
157MAP3K50.40075397
158CAMK1D0.39750818
159TESK20.39181148
160CDK11A0.38929425
161MAP2K60.38881318
162CSNK1D0.38341693
163CSNK2A10.36798610
164RPS6KA20.36212774
165PRKCZ0.34351981
166OXSR10.34204438
167PRKCB0.34105488
168EGFR0.33133533
169PRKACA0.32531164
170DYRK1A0.30091936
171TIE10.29340102

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.83966925
2Synaptic vesicle cycle_Homo sapiens_hsa047213.08120774
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.06613264
4Nicotine addiction_Homo sapiens_hsa050333.04016972
5Proteasome_Homo sapiens_hsa030502.81351870
6Oxidative phosphorylation_Homo sapiens_hsa001902.76142113
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70212672
8RNA polymerase_Homo sapiens_hsa030202.63848224
9Olfactory transduction_Homo sapiens_hsa047402.59670086
10GABAergic synapse_Homo sapiens_hsa047272.55904802
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40125833
12Non-homologous end-joining_Homo sapiens_hsa034502.37472769
13Circadian entrainment_Homo sapiens_hsa047132.37216236
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36970658
15Parkinsons disease_Homo sapiens_hsa050122.33800003
16Long-term potentiation_Homo sapiens_hsa047202.26346209
17Fanconi anemia pathway_Homo sapiens_hsa034602.26155964
18Nitrogen metabolism_Homo sapiens_hsa009102.22168132
19Morphine addiction_Homo sapiens_hsa050322.19579003
20Homologous recombination_Homo sapiens_hsa034402.15974781
21Glutamatergic synapse_Homo sapiens_hsa047242.11009283
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10658258
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10528849
24Amphetamine addiction_Homo sapiens_hsa050312.05849070
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99447050
26Insulin secretion_Homo sapiens_hsa049111.94444607
27Salivary secretion_Homo sapiens_hsa049701.91479882
28Propanoate metabolism_Homo sapiens_hsa006401.90554308
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90509139
30Fatty acid elongation_Homo sapiens_hsa000621.87778050
31Dopaminergic synapse_Homo sapiens_hsa047281.83410523
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82847840
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80335455
34Peroxisome_Homo sapiens_hsa041461.75440188
35Mismatch repair_Homo sapiens_hsa034301.72239915
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.69503134
37Renin secretion_Homo sapiens_hsa049241.68232805
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67387499
39Gastric acid secretion_Homo sapiens_hsa049711.67157635
40Cholinergic synapse_Homo sapiens_hsa047251.62441111
41Base excision repair_Homo sapiens_hsa034101.59041936
42Steroid biosynthesis_Homo sapiens_hsa001001.58924443
43Selenocompound metabolism_Homo sapiens_hsa004501.58327861
44Phototransduction_Homo sapiens_hsa047441.56877842
45RNA degradation_Homo sapiens_hsa030181.52738842
46Taste transduction_Homo sapiens_hsa047421.50087610
47Huntingtons disease_Homo sapiens_hsa050161.47100099
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45449056
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44729183
50Pyrimidine metabolism_Homo sapiens_hsa002401.44279323
51Oxytocin signaling pathway_Homo sapiens_hsa049211.43609156
52Cocaine addiction_Homo sapiens_hsa050301.43578311
53Basal transcription factors_Homo sapiens_hsa030221.37009891
54Type II diabetes mellitus_Homo sapiens_hsa049301.36626407
55GnRH signaling pathway_Homo sapiens_hsa049121.35332336
56Calcium signaling pathway_Homo sapiens_hsa040201.35269521
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33684294
58One carbon pool by folate_Homo sapiens_hsa006701.29880682
59Arginine biosynthesis_Homo sapiens_hsa002201.28227569
60Nucleotide excision repair_Homo sapiens_hsa034201.27954973
61Collecting duct acid secretion_Homo sapiens_hsa049661.27603183
62Alzheimers disease_Homo sapiens_hsa050101.26687466
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26355450
64Caffeine metabolism_Homo sapiens_hsa002321.24898309
65Serotonergic synapse_Homo sapiens_hsa047261.24768245
66DNA replication_Homo sapiens_hsa030301.24453379
67Long-term depression_Homo sapiens_hsa047301.22366983
68Tryptophan metabolism_Homo sapiens_hsa003801.17097868
69cAMP signaling pathway_Homo sapiens_hsa040241.16467784
70Primary immunodeficiency_Homo sapiens_hsa053401.15820925
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15340655
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15196319
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11857620
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10109939
75Bile secretion_Homo sapiens_hsa049761.09522599
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07198232
77Spliceosome_Homo sapiens_hsa030401.06964263
78Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06203421
79Regulation of autophagy_Homo sapiens_hsa041401.05737650
80Estrogen signaling pathway_Homo sapiens_hsa049151.03722322
81Purine metabolism_Homo sapiens_hsa002301.02268424
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01560324
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00523967
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00086915
85Folate biosynthesis_Homo sapiens_hsa007900.99576386
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98852601
87beta-Alanine metabolism_Homo sapiens_hsa004100.98621198
88Gap junction_Homo sapiens_hsa045400.95758867
89Type I diabetes mellitus_Homo sapiens_hsa049400.93265399
90Linoleic acid metabolism_Homo sapiens_hsa005910.92677819
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92351393
92Pancreatic secretion_Homo sapiens_hsa049720.92275137
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90810644
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87665283
95Vibrio cholerae infection_Homo sapiens_hsa051100.86322529
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86317646
97Thyroid hormone synthesis_Homo sapiens_hsa049180.85830666
98Fatty acid metabolism_Homo sapiens_hsa012120.85764501
99Metabolic pathways_Homo sapiens_hsa011000.85004202
100* RNA transport_Homo sapiens_hsa030130.82442972
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81332474
102Glioma_Homo sapiens_hsa052140.81241314
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.77919707
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77367333
105Glucagon signaling pathway_Homo sapiens_hsa049220.76949232
106Sulfur metabolism_Homo sapiens_hsa009200.75783076
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71511317
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71293068
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.70196386
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69742235
111Ether lipid metabolism_Homo sapiens_hsa005650.69191414
112Fatty acid degradation_Homo sapiens_hsa000710.68855953
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68456546
114Chemical carcinogenesis_Homo sapiens_hsa052040.67935731
115Dilated cardiomyopathy_Homo sapiens_hsa054140.67918318
116Dorso-ventral axis formation_Homo sapiens_hsa043200.67516897
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66906529
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.64981718
119Glutathione metabolism_Homo sapiens_hsa004800.64170285
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63106220
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.63038750
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61322986
123Insulin signaling pathway_Homo sapiens_hsa049100.60699909
124ErbB signaling pathway_Homo sapiens_hsa040120.60206286
125Butanoate metabolism_Homo sapiens_hsa006500.59777997
126Cardiac muscle contraction_Homo sapiens_hsa042600.58175841
127Melanogenesis_Homo sapiens_hsa049160.57496613
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.57218970
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56344788
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.54970220
131MAPK signaling pathway_Homo sapiens_hsa040100.54234670
132Retinol metabolism_Homo sapiens_hsa008300.54148617
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54080859
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53839388
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.53831667
136Circadian rhythm_Homo sapiens_hsa047100.50658045
137mTOR signaling pathway_Homo sapiens_hsa041500.49213388
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47056545
139Prion diseases_Homo sapiens_hsa050200.46342489
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45773525
141Inositol phosphate metabolism_Homo sapiens_hsa005620.44922676
142N-Glycan biosynthesis_Homo sapiens_hsa005100.44484341
143ABC transporters_Homo sapiens_hsa020100.44157934
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43965224
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43892283
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43163494
147Oocyte meiosis_Homo sapiens_hsa041140.43106783
148Insulin resistance_Homo sapiens_hsa049310.42397186
149VEGF signaling pathway_Homo sapiens_hsa043700.38857782
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.38564157
151p53 signaling pathway_Homo sapiens_hsa041150.38273518
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37456820
153Endocytosis_Homo sapiens_hsa041440.36833844
154Rheumatoid arthritis_Homo sapiens_hsa053230.35960209
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35599989
156Glycerolipid metabolism_Homo sapiens_hsa005610.35101269
157Arachidonic acid metabolism_Homo sapiens_hsa005900.34763326
158Choline metabolism in cancer_Homo sapiens_hsa052310.34233477
159Platelet activation_Homo sapiens_hsa046110.34230914
160Asthma_Homo sapiens_hsa053100.33723666
161Drug metabolism - other enzymes_Homo sapiens_hsa009830.33305474
162Non-small cell lung cancer_Homo sapiens_hsa052230.33119684
163Sphingolipid metabolism_Homo sapiens_hsa006000.32911559
164Pyruvate metabolism_Homo sapiens_hsa006200.32084864
165Graft-versus-host disease_Homo sapiens_hsa053320.32010516
166Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31363926
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.31243305
168Allograft rejection_Homo sapiens_hsa053300.30819833
169Autoimmune thyroid disease_Homo sapiens_hsa053200.30124306
170Lysosome_Homo sapiens_hsa041420.29294723
171Chemokine signaling pathway_Homo sapiens_hsa040620.28959449
172Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27897537
173Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27672342
174SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27052275
175Prolactin signaling pathway_Homo sapiens_hsa049170.26810596
176Rap1 signaling pathway_Homo sapiens_hsa040150.26693684
177Axon guidance_Homo sapiens_hsa043600.25748507
178Sphingolipid signaling pathway_Homo sapiens_hsa040710.25372912
179Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24690649
180Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24399162

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »