ELAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.35908375
2DNA unwinding involved in DNA replication (GO:0006268)4.99465270
3nucleobase biosynthetic process (GO:0046112)4.54795015
4ribosome assembly (GO:0042255)4.51331068
5proline biosynthetic process (GO:0006561)4.48013590
6folic acid metabolic process (GO:0046655)4.27592841
7DNA replication initiation (GO:0006270)4.26068728
8formation of translation preinitiation complex (GO:0001731)4.21421740
9DNA strand elongation involved in DNA replication (GO:0006271)4.15943937
10mitotic nuclear envelope disassembly (GO:0007077)4.13415455
11nuclear pore organization (GO:0006999)4.09811913
12IMP biosynthetic process (GO:0006188)4.09731380
13ribosome biogenesis (GO:0042254)4.03062990
14COPI coating of Golgi vesicle (GO:0048205)4.01926218
15Golgi transport vesicle coating (GO:0048200)4.01926218
16DNA replication-dependent nucleosome organization (GO:0034723)4.01343889
17DNA replication-dependent nucleosome assembly (GO:0006335)4.01343889
18DNA strand elongation (GO:0022616)3.96982941
19peptidyl-arginine methylation (GO:0018216)3.95484411
20peptidyl-arginine N-methylation (GO:0035246)3.95484411
21protein localization to kinetochore (GO:0034501)3.95350576
22regulation of translational termination (GO:0006449)3.94750176
23purine nucleobase biosynthetic process (GO:0009113)3.93484428
24membrane disassembly (GO:0030397)3.88381212
25nuclear envelope disassembly (GO:0051081)3.88381212
26glycine metabolic process (GO:0006544)3.86840576
27maturation of SSU-rRNA (GO:0030490)3.77788471
28nuclear pore complex assembly (GO:0051292)3.71517859
29IMP metabolic process (GO:0046040)3.70035316
30establishment of integrated proviral latency (GO:0075713)3.60594535
31regulation of posttranscriptional gene silencing (GO:0060147)3.59251788
32regulation of gene silencing by miRNA (GO:0060964)3.59251788
33regulation of gene silencing by RNA (GO:0060966)3.59251788
34mitotic metaphase plate congression (GO:0007080)3.58440102
35DNA deamination (GO:0045006)3.57135800
36protein localization to chromosome, centromeric region (GO:0071459)3.55975314
37ribonucleoprotein complex biogenesis (GO:0022613)3.53926366
38DNA duplex unwinding (GO:0032508)3.49957261
39pore complex assembly (GO:0046931)3.49475870
40DNA replication checkpoint (GO:0000076)3.49305417
41telomere maintenance via semi-conservative replication (GO:0032201)3.48882506
42nucleobase-containing small molecule interconversion (GO:0015949)3.48661740
43DNA geometric change (GO:0032392)3.45759876
44protein maturation by protein folding (GO:0022417)3.43675952
45rRNA transcription (GO:0009303)3.43653577
46regulation of translational fidelity (GO:0006450)3.43191781
47spliceosomal tri-snRNP complex assembly (GO:0000244)3.41470296
48tetrahydrofolate metabolic process (GO:0046653)3.40483867
49pre-miRNA processing (GO:0031054)3.38656038
50rRNA processing (GO:0006364)3.35789520
51viral transcription (GO:0019083)3.32980597
52negative regulation of histone methylation (GO:0031061)3.32054671
53regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32053679
54translational termination (GO:0006415)3.30442213
55translational initiation (GO:0006413)3.29822709
56regulation of mitochondrial translation (GO:0070129)3.29036709
57heterochromatin organization (GO:0070828)3.28848337
58pteridine-containing compound biosynthetic process (GO:0042559)3.27896680
59regulation of histone H3-K9 methylation (GO:0051570)3.27408720
60rRNA metabolic process (GO:0016072)3.26028488
61histone H4-K12 acetylation (GO:0043983)3.23634742
62translational elongation (GO:0006414)3.23225787
63ribosomal large subunit biogenesis (GO:0042273)3.23086889
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21969394
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20687453
66pentose-phosphate shunt (GO:0006098)3.20671779
67folic acid-containing compound metabolic process (GO:0006760)3.20477408
68mitotic nuclear envelope reassembly (GO:0007084)3.16612430
69nuclear envelope reassembly (GO:0031468)3.16612430
70spliceosomal snRNP assembly (GO:0000387)3.16581486
71establishment of apical/basal cell polarity (GO:0035089)3.14866855
72L-serine metabolic process (GO:0006563)3.13084689
73serine family amino acid biosynthetic process (GO:0009070)3.10991273
74peptidyl-arginine omega-N-methylation (GO:0035247)3.10819266
75negative regulation of cell size (GO:0045792)3.10408130
76nuclear envelope organization (GO:0006998)3.09969265
77mitochondrial fusion (GO:0008053)3.09718260
78protein retention in ER lumen (GO:0006621)3.09598581
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04985726
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03618674
81viral mRNA export from host cell nucleus (GO:0046784)3.02269125
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00948061
83establishment of viral latency (GO:0019043)3.00844191
84metaphase plate congression (GO:0051310)2.99806362
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99713929
86ribosomal small subunit biogenesis (GO:0042274)2.95509637
87amino acid activation (GO:0043038)2.95422151
88tRNA aminoacylation (GO:0043039)2.95422151
89polarized epithelial cell differentiation (GO:0030859)2.94180421
90DNA topological change (GO:0006265)2.93401128
91positive regulation of chromosome segregation (GO:0051984)2.92144157
92telomere maintenance via telomere lengthening (GO:0010833)2.91113679
93mitotic sister chromatid segregation (GO:0000070)2.90399041
94protein complex localization (GO:0031503)2.88767789
95telomere maintenance via recombination (GO:0000722)2.86830401
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86258549
97mitotic G1 DNA damage checkpoint (GO:0031571)2.86148545
98NADPH regeneration (GO:0006740)2.85628035
99mitotic chromosome condensation (GO:0007076)2.85565104
100base-excision repair (GO:0006284)2.85132173
101ribosomal small subunit assembly (GO:0000028)2.84467701
102negative regulation of RNA splicing (GO:0033119)2.82546236
103protein localization to chromosome (GO:0034502)2.81715066
104negative regulation of mRNA processing (GO:0050686)2.81207083
105regulation of spindle organization (GO:0090224)2.81141234
106translesion synthesis (GO:0019985)2.81041045
107chromatin assembly (GO:0031497)2.80092234
108regulation of translational elongation (GO:0006448)2.79454852
109cellular protein complex localization (GO:0034629)2.79134607
110pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.77357023
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76734029
112regulation of helicase activity (GO:0051095)2.76664684
113proline metabolic process (GO:0006560)2.75827851
114glucose catabolic process (GO:0006007)2.75731666
115chaperone-mediated protein complex assembly (GO:0051131)2.75348571
116protein export from nucleus (GO:0006611)2.74829587
117tRNA aminoacylation for protein translation (GO:0006418)2.74074570
118mitotic recombination (GO:0006312)2.73940627
119mitochondrial DNA metabolic process (GO:0032042)2.73146274
120NADH metabolic process (GO:0006734)2.72592966
121negative regulation of mRNA metabolic process (GO:1903312)2.71543823
122one-carbon metabolic process (GO:0006730)2.71367952
123serine family amino acid metabolic process (GO:0009069)2.69735589
124DNA conformation change (GO:0071103)2.68023812
1253-UTR-mediated mRNA stabilization (GO:0070935)2.67601228
126protein-DNA complex disassembly (GO:0032986)2.67560025
127nucleosome disassembly (GO:0006337)2.67560025
128sister chromatid segregation (GO:0000819)2.67471165
129histone arginine methylation (GO:0034969)2.67023807
130snRNA metabolic process (GO:0016073)2.66463746
131mRNA splicing, via spliceosome (GO:0000398)2.66368551
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66368551
133pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.65560651
134UMP biosynthetic process (GO:0006222)2.65560651
135pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.65560651
136UMP metabolic process (GO:0046049)2.65560651
137RNA splicing, via transesterification reactions (GO:0000375)2.65244726
138establishment of monopolar cell polarity (GO:0061162)2.65223773
139establishment or maintenance of monopolar cell polarity (GO:0061339)2.65223773
140transcription from mitochondrial promoter (GO:0006390)2.65037272
141tRNA methylation (GO:0030488)2.64949919
142apoptotic process involved in morphogenesis (GO:0060561)2.60839684
143pentose metabolic process (GO:0019321)2.59890817
144regulation of mitotic spindle organization (GO:0060236)2.59824838
145pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.59449796
146chromosome condensation (GO:0030261)2.57472720
147pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.54062768
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.53818741
149UV protection (GO:0009650)2.52233254
150pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.51985653
151RNA stabilization (GO:0043489)2.51159829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61702784
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.15083092
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87114145
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.48355263
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95461926
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89143230
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66118842
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64534011
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59180920
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.51272861
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25258719
12MYC_22102868_ChIP-Seq_BL_Human2.20305172
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19039882
14XRN2_22483619_ChIP-Seq_HELA_Human2.18997363
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.17102424
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15790951
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14933574
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14216896
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08059492
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.01611560
21AR_21909140_ChIP-Seq_LNCAP_Human2.00070784
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.89672371
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81254607
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81250677
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80381529
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80254590
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.78018227
28VDR_23849224_ChIP-Seq_CD4+_Human1.77227852
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76159931
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74908017
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73583340
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.71438679
33FOXP3_21729870_ChIP-Seq_TREG_Human1.71253268
34GABP_19822575_ChIP-Seq_HepG2_Human1.69912225
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68674819
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68646325
37CIITA_25753668_ChIP-Seq_RAJI_Human1.68087136
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66981396
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66277793
40KDM5A_27292631_Chip-Seq_BREAST_Human1.64964972
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64330119
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63844184
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63229589
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60008742
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.59840347
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58804407
47TTF2_22483619_ChIP-Seq_HELA_Human1.57046916
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56790333
49LXR_22292898_ChIP-Seq_THP-1_Human1.47268995
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.45343322
51RACK7_27058665_Chip-Seq_MCF-7_Human1.41307741
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40778393
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39853624
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38836847
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36926554
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36730560
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35406355
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.34899301
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33622476
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32816590
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32413552
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31812076
63* ZNF263_19887448_ChIP-Seq_K562_Human1.30809838
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30665229
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30478923
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27763388
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23495575
68VDR_21846776_ChIP-Seq_THP-1_Human1.21393464
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19508439
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18360448
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12687613
72P68_20966046_ChIP-Seq_HELA_Human1.11570822
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10502495
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09943083
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09483048
76TFEB_21752829_ChIP-Seq_HELA_Human1.09160557
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08465480
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07029899
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06972235
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06678569
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06219110
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06137591
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05704168
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05298900
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05215597
86TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04769155
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04509556
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04120858
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03539449
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03286343
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01131331
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00307959
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99826611
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99810575
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98035994
96CLOCK_20551151_ChIP-Seq_293T_Human0.97600815
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96786972
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96621721
99TCF7_22412390_ChIP-Seq_EML_Mouse0.96435152
100CHD1_26751641_Chip-Seq_LNCaP_Human0.95973370
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95213052
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95203679
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.95034090
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94899755
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.94210702
106ELK1_19687146_ChIP-ChIP_HELA_Human0.93612832
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93464769
108* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92334398
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91987177
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91620860
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90916050
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90635291
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90438547
114ATF3_27146783_Chip-Seq_COLON_Human0.89438975
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88903436
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.88593380
117* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88295418
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88191186
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88153400
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87317913
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86016019
122* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85368819
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.84968683
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84489056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.65995740
2MP0003111_abnormal_nucleus_morphology4.10985035
3MP0004957_abnormal_blastocyst_morpholog4.08922646
4MP0010094_abnormal_chromosome_stability3.85901869
5MP0003806_abnormal_nucleotide_metabolis3.58290818
6MP0003077_abnormal_cell_cycle3.34403747
7MP0010352_gastrointestinal_tract_polyps2.98326649
8MP0008057_abnormal_DNA_replication2.80896049
9MP0003123_paternal_imprinting2.72171177
10MP0001730_embryonic_growth_arrest2.66698530
11MP0003705_abnormal_hypodermis_morpholog2.42880912
12MP0002139_abnormal_hepatobiliary_system2.30948140
13MP0008058_abnormal_DNA_repair2.22279675
14MP0008260_abnormal_autophagy2.20314977
15MP0008932_abnormal_embryonic_tissue2.07994256
16MP0000350_abnormal_cell_proliferation2.06414412
17MP0008877_abnormal_DNA_methylation1.96343558
18MP0005380_embryogenesis_phenotype1.86718536
19MP0001672_abnormal_embryogenesis/_devel1.86718536
20MP0008007_abnormal_cellular_replicative1.82943362
21MP0001697_abnormal_embryo_size1.82449343
22MP0010307_abnormal_tumor_latency1.81353467
23MP0001661_extended_life_span1.80679549
24MP0002396_abnormal_hematopoietic_system1.75511151
25MP0002080_prenatal_lethality1.75326310
26MP0004197_abnormal_fetal_growth/weight/1.73603574
27MP0003984_embryonic_growth_retardation1.72847468
28MP0009840_abnormal_foam_cell1.72243525
29MP0002088_abnormal_embryonic_growth/wei1.71076684
30MP0005076_abnormal_cell_differentiation1.70372617
31MP0003567_abnormal_fetal_cardiomyocyte1.69760878
32MP0005360_urolithiasis1.67366064
33MP0000678_abnormal_parathyroid_gland1.65475188
34MP0002084_abnormal_developmental_patter1.63925528
35MP0000751_myopathy1.61912928
36MP0003786_premature_aging1.60527842
37MP0002086_abnormal_extraembryonic_tissu1.59801923
38MP0002085_abnormal_embryonic_tissue1.58589639
39MP0005058_abnormal_lysosome_morphology1.57887536
40MP0004858_abnormal_nervous_system1.56013007
41MP0002796_impaired_skin_barrier1.54385178
42MP0005365_abnormal_bile_salt1.54382214
43MP0000003_abnormal_adipose_tissue1.51242665
44MP0005623_abnormal_meninges_morphology1.50701667
45MP0003718_maternal_effect1.49579996
46MP0005085_abnormal_gallbladder_physiolo1.49116247
47MP0003221_abnormal_cardiomyocyte_apopto1.34024499
48MP0004185_abnormal_adipocyte_glucose1.29395016
49MP0002653_abnormal_ependyma_morphology1.28580771
50MP0002019_abnormal_tumor_incidence1.28348504
51MP0004233_abnormal_muscle_weight1.25933225
52MP0000579_abnormal_nail_morphology1.23062560
53MP0004264_abnormal_extraembryonic_tissu1.22585651
54MP0000313_abnormal_cell_death1.21333157
55MP0000358_abnormal_cell_content/1.21078459
56MP0000733_abnormal_muscle_development1.20584258
57MP0009672_abnormal_birth_weight1.18961978
58MP0003941_abnormal_skin_development1.18494325
59MP0000490_abnormal_crypts_of1.18322565
60MP0005621_abnormal_cell_physiology1.17950003
61MP0003121_genomic_imprinting1.17803470
62MP0003453_abnormal_keratinocyte_physiol1.17056075
63MP0000747_muscle_weakness1.15824936
64MP0005666_abnormal_adipose_tissue1.14772999
65MP0003119_abnormal_digestive_system1.13693312
66MP0000759_abnormal_skeletal_muscle1.13408886
67MP0005670_abnormal_white_adipose1.12911961
68MP0009053_abnormal_anal_canal1.09694444
69MP0000609_abnormal_liver_physiology1.06744670
70MP0002877_abnormal_melanocyte_morpholog1.06095733
71MP0000762_abnormal_tongue_morphology1.04928423
72MP0004272_abnormal_basement_membrane1.03506759
73MP0002269_muscular_atrophy1.03260074
74MP0004087_abnormal_muscle_fiber1.02604186
75MP0009697_abnormal_copulation1.02474903
76MP0002060_abnormal_skin_morphology1.01448196
77MP0001293_anophthalmia1.00341527
78MP0002210_abnormal_sex_determination1.00338274
79MP0000467_abnormal_esophagus_morphology0.99574469
80MP0005375_adipose_tissue_phenotype0.99054588
81MP0005023_abnormal_wound_healing0.98766523
82MP0006035_abnormal_mitochondrial_morpho0.97984315
83MP0000749_muscle_degeneration0.96805194
84MP0006036_abnormal_mitochondrial_physio0.96200455
85MP0001216_abnormal_epidermal_layer0.96134236
86MP0004808_abnormal_hematopoietic_stem0.96081768
87MP0010234_abnormal_vibrissa_follicle0.96060740
88MP0001145_abnormal_male_reproductive0.95884137
89MP0003890_abnormal_embryonic-extraembry0.94817283
90MP0003566_abnormal_cell_adhesion0.94562540
91MP0000598_abnormal_liver_morphology0.94178778
92MP0003763_abnormal_thymus_physiology0.91488102
93MP0005257_abnormal_intraocular_pressure0.90252871
94MP0001929_abnormal_gametogenesis0.89686182
95MP0000750_abnormal_muscle_regeneration0.89645605
96MP0001727_abnormal_embryo_implantation0.87894099
97MP0005266_abnormal_metabolism0.86934271
98MP0002089_abnormal_postnatal_growth/wei0.86055197
99MP0001348_abnormal_lacrimal_gland0.85750042
100MP0000703_abnormal_thymus_morphology0.85335738
101MP0003252_abnormal_bile_duct0.85175664
102MP0005451_abnormal_body_composition0.85174101
103MP0000537_abnormal_urethra_morphology0.84542576
104MP0001849_ear_inflammation0.83662601
105MP0005501_abnormal_skin_physiology0.83334475
106MP0000477_abnormal_intestine_morphology0.82029204
107MP0003646_muscle_fatigue0.80581306
108MP0004133_heterotaxia0.79307940
109MP0000653_abnormal_sex_gland0.78354902
110MP0005397_hematopoietic_system_phenotyp0.77367205
111MP0001545_abnormal_hematopoietic_system0.77367205
112MP0002697_abnormal_eye_size0.76763753
113MP0005384_cellular_phenotype0.76202849
114MP0004147_increased_porphyrin_level0.74745028
115MP0009333_abnormal_splenocyte_physiolog0.74719175
116MP0003186_abnormal_redox_activity0.74492687
117MP0000858_altered_metastatic_potential0.74455956
118MP0002722_abnormal_immune_system0.74334682
119MP0002111_abnormal_tail_morphology0.73294435
120MP0000377_abnormal_hair_follicle0.72011255
121MP0001881_abnormal_mammary_gland0.71614546
122MP0009278_abnormal_bone_marrow0.71352216
123MP0001915_intracranial_hemorrhage0.70974313
124MP0002092_abnormal_eye_morphology0.70826250
125MP0010030_abnormal_orbit_morphology0.70783907
126MP0003385_abnormal_body_wall0.70777438
127MP0002249_abnormal_larynx_morphology0.70504999
128MP0010329_abnormal_lipoprotein_level0.70225015
129MP0001346_abnormal_lacrimal_gland0.69460435
130MP0009931_abnormal_skin_appearance0.68953965
131MP0008770_decreased_survivor_rate0.68268875
132MP0002398_abnormal_bone_marrow0.67008480
133MP0000689_abnormal_spleen_morphology0.66712290
134MP0010630_abnormal_cardiac_muscle0.66664185
135MP0005319_abnormal_enzyme/_coenzyme0.66617149
136MP0005330_cardiomyopathy0.65732064
137MP0009703_decreased_birth_body0.65699920
138MP0003315_abnormal_perineum_morphology0.65431084

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.28030153
2Ragged-red muscle fibers (HP:0003200)3.92328192
3Hyperacusis (HP:0010780)3.85533421
4Birth length less than 3rd percentile (HP:0003561)3.66543497
5Degeneration of anterior horn cells (HP:0002398)3.65242062
6Abnormality of the anterior horn cell (HP:0006802)3.65242062
7Microvesicular hepatic steatosis (HP:0001414)3.63016143
8Reticulocytopenia (HP:0001896)3.41292802
9Abnormality of pyrimidine metabolism (HP:0004353)3.25023167
10Selective tooth agenesis (HP:0001592)3.13871361
11Abnormality of cells of the erythroid lineage (HP:0012130)3.08103421
12Oral leukoplakia (HP:0002745)3.04717945
13Medulloblastoma (HP:0002885)2.97167746
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.97151527
15Abnormal number of erythroid precursors (HP:0012131)2.84850556
16Rough bone trabeculation (HP:0100670)2.82366034
17Multiple enchondromatosis (HP:0005701)2.80737746
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.76722124
19Rhabdomyosarcoma (HP:0002859)2.76463400
20Colon cancer (HP:0003003)2.64384826
21Abnormality of the astrocytes (HP:0100707)2.63932435
22Astrocytoma (HP:0009592)2.63932435
23Basal cell carcinoma (HP:0002671)2.63312439
24Impulsivity (HP:0100710)2.60949771
25Distal lower limb amyotrophy (HP:0008944)2.58285328
26Spastic diplegia (HP:0001264)2.57404968
27Adenoma sebaceum (HP:0009720)2.55328930
28Angiofibromas (HP:0010615)2.55328930
29Hypobetalipoproteinemia (HP:0003563)2.54116779
30Increased connective tissue (HP:0009025)2.51711658
31Progressive external ophthalmoplegia (HP:0000590)2.51140293
32Macrocytic anemia (HP:0001972)2.50469424
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49316634
34Abnormality of glycolysis (HP:0004366)2.49224632
35Neoplasm of the pancreas (HP:0002894)2.48342662
36Spinal muscular atrophy (HP:0007269)2.46785180
37Proximal placement of thumb (HP:0009623)2.45697774
38Abnormality of reticulocytes (HP:0004312)2.45268791
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.45120323
40Abnormality of the lower motor neuron (HP:0002366)2.44787769
41Absent thumb (HP:0009777)2.44505960
42Abnormality of the labia minora (HP:0012880)2.42639797
43Breast hypoplasia (HP:0003187)2.42404966
44Achilles tendon contracture (HP:0001771)2.41653394
45Deviation of the thumb (HP:0009603)2.38645513
46Neoplasm of striated muscle (HP:0009728)2.38537807
47Vertebral compression fractures (HP:0002953)2.36476944
48Abnormality of the umbilical cord (HP:0010881)2.35514247
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.34794207
50Hyperglycinemia (HP:0002154)2.33217699
51Carpal bone hypoplasia (HP:0001498)2.33187344
52Back pain (HP:0003418)2.33014648
53Intrahepatic cholestasis (HP:0001406)2.32968146
54Cerebral hypomyelination (HP:0006808)2.32426631
55Entropion (HP:0000621)2.30992263
56Hyperglycinuria (HP:0003108)2.29632208
57Abnormal gallbladder physiology (HP:0012438)2.29534988
58Cholecystitis (HP:0001082)2.29534988
59Ulnar bowing (HP:0003031)2.27653963
60Broad distal phalanx of finger (HP:0009836)2.27083461
61Myopathic facies (HP:0002058)2.26217464
62Premature rupture of membranes (HP:0001788)2.25748297
63Premature ovarian failure (HP:0008209)2.23929267
64Glioma (HP:0009733)2.22961395
65Increased nuchal translucency (HP:0010880)2.22078364
66Pallor (HP:0000980)2.19785345
67Abnormality of the motor neurons (HP:0002450)2.16835275
68Abnormal neuron morphology (HP:0012757)2.16835275
69Abnormality of the distal phalanges of the toes (HP:0010182)2.16084597
70Hyperammonemia (HP:0001987)2.11496263
71Short nail (HP:0001799)2.11374872
72Distal lower limb muscle weakness (HP:0009053)2.11217387
73Abnormality of serine family amino acid metabolism (HP:0010894)2.11011894
74Abnormality of glycine metabolism (HP:0010895)2.11011894
75Neoplasm of the oral cavity (HP:0100649)2.10052882
76Late onset (HP:0003584)2.09480014
77Trismus (HP:0000211)2.09409023
78Cellular immunodeficiency (HP:0005374)2.09051428
79Increased serum pyruvate (HP:0003542)2.07427998
80Overriding aorta (HP:0002623)2.07288576
81Premature graying of hair (HP:0002216)2.07179239
82Patellar aplasia (HP:0006443)2.05250680
83Difficulty climbing stairs (HP:0003551)2.04703308
84Rhabdomyolysis (HP:0003201)2.04593031
85Poikiloderma (HP:0001029)2.04589321
86Biliary tract neoplasm (HP:0100574)2.03500654
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.03124055
88Stridor (HP:0010307)2.01632485
89Abnormality of the Achilles tendon (HP:0005109)2.01202965
90Truncus arteriosus (HP:0001660)2.00760180
91Progressive muscle weakness (HP:0003323)2.00633129
92Exercise-induced myalgia (HP:0003738)1.98005006
93Nausea (HP:0002018)1.97891854
94Megaloblastic anemia (HP:0001889)1.96813733
95Abnormal number of incisors (HP:0011064)1.96501569
96Long palpebral fissure (HP:0000637)1.96371520
97Cafe-au-lait spot (HP:0000957)1.94165718
98Microretrognathia (HP:0000308)1.92443261
99Pseudobulbar signs (HP:0002200)1.92374330
100Squamous cell carcinoma (HP:0002860)1.92015018
101Reticulocytosis (HP:0001923)1.91255285
102Missing ribs (HP:0000921)1.91167077
103Testicular atrophy (HP:0000029)1.90926798
104Chromsome breakage (HP:0040012)1.90828015
105Elfin facies (HP:0004428)1.90007408
106Progressive sensorineural hearing impairment (HP:0000408)1.89739170
107Patellar dislocation (HP:0002999)1.89219550
108Aplasia/Hypoplasia of the patella (HP:0006498)1.88318538
109Distal upper limb amyotrophy (HP:0007149)1.87844114
110Upper limb amyotrophy (HP:0009129)1.87844114
111Insomnia (HP:0100785)1.87741059
112Abnormality of methionine metabolism (HP:0010901)1.87502276
113Spinal rigidity (HP:0003306)1.87033268
114Natal tooth (HP:0000695)1.85864723
115Absent radius (HP:0003974)1.85569611
116Abnormality of chromosome stability (HP:0003220)1.84962240
117Cutaneous melanoma (HP:0012056)1.84030990
118Abnormal trabecular bone morphology (HP:0100671)1.83371667
119Atresia of the external auditory canal (HP:0000413)1.82358947
120Posterior subcapsular cataract (HP:0007787)1.81895300
121Deep venous thrombosis (HP:0002625)1.81036778
122Unilateral renal agenesis (HP:0000122)1.80239371
123Abnormality of the fetal cardiovascular system (HP:0010948)1.79801910
124Abnormal umbilical cord blood vessels (HP:0011403)1.79801910
125Single umbilical artery (HP:0001195)1.79801910
126Abnormality of the calcaneus (HP:0008364)1.77855093
12711 pairs of ribs (HP:0000878)1.77292057
128High anterior hairline (HP:0009890)1.77058181
129Tongue fasciculations (HP:0001308)1.77045774
130Muscle fibrillation (HP:0010546)1.76769930
131Pelvic girdle muscle weakness (HP:0003749)1.76492346
132Secondary amenorrhea (HP:0000869)1.74650788
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74033977
134Shoulder girdle muscle weakness (HP:0003547)1.73475613
135Horseshoe kidney (HP:0000085)1.73415034
136Premature skin wrinkling (HP:0100678)1.72762950
137Postnatal microcephaly (HP:0005484)1.72693426
138Elbow flexion contracture (HP:0002987)1.72441378
139Fasciculations (HP:0002380)1.71515329
140Dysmetric saccades (HP:0000641)1.71443368
141Hypoglycemic coma (HP:0001325)1.71231010
142Amaurosis fugax (HP:0100576)1.69820725
143Bone marrow hypocellularity (HP:0005528)1.69696368
144Hypergonadotropic hypogonadism (HP:0000815)1.69562248
145Muscle stiffness (HP:0003552)1.69450172
146Agnosia (HP:0010524)1.69285899
147Prominent nose (HP:0000448)1.69125228
148Myelodysplasia (HP:0002863)1.68676814
149Pointed chin (HP:0000307)1.68569741
150Diaphragmatic weakness (HP:0009113)1.67338910
151Lower limb amyotrophy (HP:0007210)1.66511626
152Hypolipoproteinemia (HP:0010981)1.66326169
153Skin tags (HP:0010609)1.66296729
154Abnormality of the preputium (HP:0100587)1.65480662
155Abnormality of the tricuspid valve (HP:0001702)1.65442730
156Abnormalities of placenta or umbilical cord (HP:0001194)1.65198656
157Generalized amyotrophy (HP:0003700)1.64766119
158Hypokinesia (HP:0002375)1.63940540
159Sparse lateral eyebrow (HP:0005338)1.63074390
160Fragile skin (HP:0001030)1.62355856
161Advanced eruption of teeth (HP:0006288)1.60799229
162Orthostatic hypotension (HP:0001278)1.60722461
163Progressive hearing impairment (HP:0001730)1.60370114
164Athetosis (HP:0002305)1.59948485
165Renal duplication (HP:0000075)1.57989277
166Breech presentation (HP:0001623)1.57987674
167Protrusio acetabuli (HP:0003179)1.57631663
168Onycholysis (HP:0001806)1.56887553
169Glossoptosis (HP:0000162)1.56051854
170Ankyloglossia (HP:0010296)1.55397320
171Pili torti (HP:0003777)1.54440424
172Abnormality of oral frenula (HP:0000190)1.53459311
173Abnormality of the thoracic spine (HP:0100711)1.52552397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.46952421
2CDC73.61370288
3BUB13.58553206
4WEE13.44378881
5EEF2K3.15191349
6TRIB32.93559068
7CDK122.86891695
8PKN22.50764566
9IRAK32.43079806
10BCKDK2.42731755
11MAP3K102.39205465
12NEK12.37576771
13TESK22.37413758
14VRK22.31541782
15NEK22.30662249
16TTK2.29802282
17TSSK61.93965364
18SCYL21.92156887
19RPS6KB21.91418738
20PBK1.86765474
21CDK41.79278091
22EIF2AK11.78661260
23NME21.67522383
24PLK11.65260122
25PRPF4B1.64842252
26STK101.60761937
27PIM21.60634446
28MST1R1.59405487
29MAP3K81.58517188
30DYRK31.49343046
31TLK11.45225090
32ARAF1.44051771
33CDK71.40291637
34PASK1.39491904
35ATR1.38948417
36AURKB1.38351227
37ALK1.38147299
38EPHA21.31366381
39RPS6KA41.26549616
40BRSK21.26317648
41CHEK11.26213985
42SRPK11.23446771
43AURKA1.21548625
44PDK31.17577173
45PDK41.17577173
46IRAK41.17437575
47CHEK21.10990517
48MAP4K11.10482983
49FLT31.06516343
50MTOR1.04765349
51ACVR1B1.04574285
52MAPKAPK31.02505527
53BRAF1.01054703
54KDR0.99477794
55BRD40.98700815
56CDK80.98121493
57TAF10.97575383
58LRRK20.93605907
59TTN0.91429696
60CDK20.90550302
61VRK10.90429094
62PLK30.88827716
63MET0.87583598
64PLK40.83720994
65PAK40.80854170
66MAP3K110.79325270
67CDK60.79307177
68EIF2AK30.78520263
69ATM0.77101554
70MAP2K30.76531543
71LATS20.76323300
72TGFBR10.76220551
73STK38L0.75840442
74PNCK0.75454188
75FGFR40.75413213
76PAK10.74904403
77BRSK10.72759905
78MKNK10.72759479
79PTK20.72111883
80TAOK10.71867441
81PAK20.71118351
82DAPK10.69738359
83MAP3K30.68476265
84CSNK2A20.68151620
85ICK0.67852362
86GRK60.67476210
87MAPKAPK50.67074801
88MAP3K130.66842314
89CDK90.66204990
90FGFR10.65596120
91STK160.65160486
92LIMK10.61361183
93PIM10.60632486
94RIPK10.60160710
95ILK0.59318471
96CDK10.59163834
97ZAP700.59156701
98STK40.58753312
99BMX0.58020954
100MKNK20.57547159
101AKT20.56369389
102CSNK1E0.55711978
103MAPK110.55684644
104CLK10.55640409
105MAP2K20.55262306
106NME10.53241617
107RAF10.51882739
108MELK0.49761584
109STK30.48560074
110KSR20.48533531
111PRKD30.47362685
112TESK10.46110008
113PTK60.44346408
114CSNK2A10.43654726
115CAMK1D0.42623222
116RPS6KA10.41564449
117CSNK1G30.41497859
118PRKCI0.37901103
119LMTK20.37546102
120CSNK1D0.37436642
121NTRK10.37245205
122PDK20.37091025
123PRKDC0.36785054
124ERBB40.36616970
125DAPK30.35547910
126ABL20.35051822
127ERN10.34184488
128TAOK20.33920905
129PDGFRA0.33864910
130CDK11A0.32352030
131LATS10.31664773
132SIK10.30583425
133TYK20.26578462
134MAPK140.26466329

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.23022466
2Mismatch repair_Homo sapiens_hsa034303.56816006
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54172564
4One carbon pool by folate_Homo sapiens_hsa006703.32790621
5* RNA transport_Homo sapiens_hsa030132.93687100
6Spliceosome_Homo sapiens_hsa030402.82342102
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74550517
8Ribosome_Homo sapiens_hsa030102.58723506
9Base excision repair_Homo sapiens_hsa034102.21215952
10RNA polymerase_Homo sapiens_hsa030202.17672313
11Cell cycle_Homo sapiens_hsa041102.13630665
12Nucleotide excision repair_Homo sapiens_hsa034202.04920321
13Pyrimidine metabolism_Homo sapiens_hsa002401.96353638
14Proteasome_Homo sapiens_hsa030501.96249099
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95601508
16Biosynthesis of amino acids_Homo sapiens_hsa012301.94157485
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.87052013
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80903722
19Homologous recombination_Homo sapiens_hsa034401.79058658
20Selenocompound metabolism_Homo sapiens_hsa004501.75433024
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71595976
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66601154
23Carbon metabolism_Homo sapiens_hsa012001.64837244
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.62400795
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.57273895
26mRNA surveillance pathway_Homo sapiens_hsa030151.55760620
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48981302
28Nitrogen metabolism_Homo sapiens_hsa009101.46642033
29Folate biosynthesis_Homo sapiens_hsa007901.34473278
30RNA degradation_Homo sapiens_hsa030181.33839133
31Fanconi anemia pathway_Homo sapiens_hsa034601.32978697
32p53 signaling pathway_Homo sapiens_hsa041151.19611586
33Pentose phosphate pathway_Homo sapiens_hsa000301.17187114
34Sulfur relay system_Homo sapiens_hsa041221.16968919
35Pyruvate metabolism_Homo sapiens_hsa006201.16498609
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12248033
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10541874
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08097568
39Systemic lupus erythematosus_Homo sapiens_hsa053221.06233364
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.05812480
41Fatty acid degradation_Homo sapiens_hsa000711.05667300
42Arginine biosynthesis_Homo sapiens_hsa002201.05183374
43N-Glycan biosynthesis_Homo sapiens_hsa005101.02481963
44Non-homologous end-joining_Homo sapiens_hsa034500.96718998
45Caffeine metabolism_Homo sapiens_hsa002320.96494877
46Other glycan degradation_Homo sapiens_hsa005110.93676050
47Lysine degradation_Homo sapiens_hsa003100.92585404
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90355324
49Basal transcription factors_Homo sapiens_hsa030220.89913991
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89155368
51Propanoate metabolism_Homo sapiens_hsa006400.87712484
52Pancreatic cancer_Homo sapiens_hsa052120.87696401
53Vitamin B6 metabolism_Homo sapiens_hsa007500.85511294
54Non-small cell lung cancer_Homo sapiens_hsa052230.84786761
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82918696
56Epstein-Barr virus infection_Homo sapiens_hsa051690.82430833
57Purine metabolism_Homo sapiens_hsa002300.81773119
58Viral carcinogenesis_Homo sapiens_hsa052030.80319221
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79535816
60Antigen processing and presentation_Homo sapiens_hsa046120.78818251
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.78246505
62Tryptophan metabolism_Homo sapiens_hsa003800.75469756
63Notch signaling pathway_Homo sapiens_hsa043300.72161417
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70674233
65Fatty acid elongation_Homo sapiens_hsa000620.70124980
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68180945
67Apoptosis_Homo sapiens_hsa042100.64359813
68Oocyte meiosis_Homo sapiens_hsa041140.62735321
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62726233
70Endometrial cancer_Homo sapiens_hsa052130.60945071
71Insulin signaling pathway_Homo sapiens_hsa049100.60927279
72Fatty acid metabolism_Homo sapiens_hsa012120.60315884
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59983505
74Thyroid cancer_Homo sapiens_hsa052160.59358820
75HTLV-I infection_Homo sapiens_hsa051660.57421304
76Glutathione metabolism_Homo sapiens_hsa004800.54388373
77Shigellosis_Homo sapiens_hsa051310.53797828
78Arginine and proline metabolism_Homo sapiens_hsa003300.51178989
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50525698
80beta-Alanine metabolism_Homo sapiens_hsa004100.50256059
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48581078
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47677900
83Fat digestion and absorption_Homo sapiens_hsa049750.45344895
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45041325
85Fructose and mannose metabolism_Homo sapiens_hsa000510.43910014
86Prion diseases_Homo sapiens_hsa050200.43769863
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43289611
88Vibrio cholerae infection_Homo sapiens_hsa051100.42504343
89Adherens junction_Homo sapiens_hsa045200.42025152
90VEGF signaling pathway_Homo sapiens_hsa043700.41449314
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.41078674
92Glioma_Homo sapiens_hsa052140.40501137
93Prostate cancer_Homo sapiens_hsa052150.39360948
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39001449
95MicroRNAs in cancer_Homo sapiens_hsa052060.38595536
96Herpes simplex infection_Homo sapiens_hsa051680.38057288
97Hepatitis B_Homo sapiens_hsa051610.37650616
98mTOR signaling pathway_Homo sapiens_hsa041500.37479559
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37399768
100Sulfur metabolism_Homo sapiens_hsa009200.36422055
101Proteoglycans in cancer_Homo sapiens_hsa052050.35375431
102Butanoate metabolism_Homo sapiens_hsa006500.34094291
103Bladder cancer_Homo sapiens_hsa052190.33331668
104Small cell lung cancer_Homo sapiens_hsa052220.33264320
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33178572
106Glucagon signaling pathway_Homo sapiens_hsa049220.33022785
107AMPK signaling pathway_Homo sapiens_hsa041520.32971563
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30325215
109Acute myeloid leukemia_Homo sapiens_hsa052210.29542967
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29077099
111Tyrosine metabolism_Homo sapiens_hsa003500.28649531
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28617292
113PPAR signaling pathway_Homo sapiens_hsa033200.28290424
114Complement and coagulation cascades_Homo sapiens_hsa046100.26942603
115Metabolic pathways_Homo sapiens_hsa011000.26916468
116Chronic myeloid leukemia_Homo sapiens_hsa052200.26868162
117Phenylalanine metabolism_Homo sapiens_hsa003600.26803171
118Galactose metabolism_Homo sapiens_hsa000520.26763787
119Renin-angiotensin system_Homo sapiens_hsa046140.26089884
120Peroxisome_Homo sapiens_hsa041460.25824569
121HIF-1 signaling pathway_Homo sapiens_hsa040660.24613735
122Colorectal cancer_Homo sapiens_hsa052100.22409071
123Fatty acid biosynthesis_Homo sapiens_hsa000610.20432539
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20267920
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20068365
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19823687
127Chemical carcinogenesis_Homo sapiens_hsa052040.19256648
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17265379
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17137768
130Hippo signaling pathway_Homo sapiens_hsa043900.16558712

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