ELANE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)9.37099697
2negative regulation of phagocytosis (GO:0050765)8.96907393
3microglial cell activation (GO:0001774)7.85309284
4regulation of MHC class II biosynthetic process (GO:0045346)7.80205105
5positive regulation of chemokine biosynthetic process (GO:0045080)7.78025747
6defense response to fungus (GO:0050832)7.53266883
7* modulation of growth of symbiont involved in interaction with host (GO:0044144)6.74150458
8* regulation of growth of symbiont in host (GO:0044126)6.74150458
9* negative regulation of growth of symbiont in host (GO:0044130)6.74150458
10* negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.74150458
11* neutrophil mediated immunity (GO:0002446)6.45536395
12* disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.45217438
13* killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.45217438
14* regulation of chemokine biosynthetic process (GO:0045073)6.38366907
15regulation of tumor necrosis factor biosynthetic process (GO:0042534)6.27276663
16reactive oxygen species biosynthetic process (GO:1903409)6.19157386
17cellular response to zinc ion (GO:0071294)6.17793155
18respiratory burst (GO:0045730)5.68391744
19* response to fungus (GO:0009620)5.49833501
20macrophage chemotaxis (GO:0048246)5.49493779
21purine deoxyribonucleotide catabolic process (GO:0009155)5.38879498
22glial cell migration (GO:0008347)5.27456763
23induction of positive chemotaxis (GO:0050930)5.22775476
24* myeloid leukocyte mediated immunity (GO:0002444)5.18758799
25ribosomal small subunit assembly (GO:0000028)5.00230143
26DNA deamination (GO:0045006)4.84533450
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.81806296
28deoxyribonucleotide catabolic process (GO:0009264)4.79602553
29glucose 6-phosphate metabolic process (GO:0051156)4.76851255
30* killing of cells of other organism (GO:0031640)4.72672829
31* disruption of cells of other organism (GO:0044364)4.72672829
32deoxyribose phosphate catabolic process (GO:0046386)4.68130912
33low-density lipoprotein particle remodeling (GO:0034374)4.64738380
34DNA strand elongation involved in DNA replication (GO:0006271)4.55104847
35innate immune response in mucosa (GO:0002227)4.48760654
36telomere maintenance via semi-conservative replication (GO:0032201)4.45333806
37positive regulation of B cell differentiation (GO:0045579)4.44569720
38hydrogen peroxide catabolic process (GO:0042744)4.36964321
39DNA strand elongation (GO:0022616)4.34535150
40macrophage activation (GO:0042116)4.25589200
41pyrimidine nucleotide catabolic process (GO:0006244)4.25029507
42negative regulation of B cell apoptotic process (GO:0002903)4.15960013
43neutrophil activation involved in immune response (GO:0002283)4.09677619
44pentose metabolic process (GO:0019321)4.08575645
45antibacterial humoral response (GO:0019731)4.04545352
46leukotriene biosynthetic process (GO:0019370)4.02235897
47ribosomal small subunit biogenesis (GO:0042274)4.00408759
48angiotensin maturation (GO:0002003)3.96072617
49pentose-phosphate shunt (GO:0006098)3.95689503
50angiogenesis involved in wound healing (GO:0060055)3.91069138
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.89443191
52positive regulation of interleukin-1 beta production (GO:0032731)3.88842110
53NADPH regeneration (GO:0006740)3.87398330
54regulation of phagocytosis (GO:0050764)3.85363678
55translational termination (GO:0006415)3.84656164
56peptide catabolic process (GO:0043171)3.84219741
57cellular response to exogenous dsRNA (GO:0071360)3.83981433
58DNA replication initiation (GO:0006270)3.83924413
59antimicrobial humoral response (GO:0019730)3.71895198
60telomere maintenance via recombination (GO:0000722)3.71474804
61IMP metabolic process (GO:0046040)3.70504097
62signal peptide processing (GO:0006465)3.69851398
63protoporphyrinogen IX biosynthetic process (GO:0006782)3.68946112
64purine deoxyribonucleotide metabolic process (GO:0009151)3.67071715
65protein localization to kinetochore (GO:0034501)3.66177912
66mucosal immune response (GO:0002385)3.55484351
67nucleobase biosynthetic process (GO:0046112)3.53085671
68* leukocyte mediated cytotoxicity (GO:0001909)3.51534874
69DNA unwinding involved in DNA replication (GO:0006268)3.50595358
70heart process (GO:0003015)3.50564019
71heart contraction (GO:0060047)3.50564019
72positive regulation of interleukin-1 production (GO:0032732)3.48419763
73organ or tissue specific immune response (GO:0002251)3.43784595
74response to xenobiotic stimulus (GO:0009410)3.41696772
75leukotriene metabolic process (GO:0006691)3.41179170
76mitotic recombination (GO:0006312)3.38673280
77DNA replication checkpoint (GO:0000076)3.38156631
782-deoxyribonucleotide metabolic process (GO:0009394)3.36570526
79centriole replication (GO:0007099)3.32818502
80positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.32265950
81Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31672355
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.29438418
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27246192
84IMP biosynthetic process (GO:0006188)3.25597934
85telomere maintenance via telomere lengthening (GO:0010833)3.22551947
86defense response to Gram-negative bacterium (GO:0050829)3.21284456
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21210092
88deoxyribose phosphate metabolic process (GO:0019692)3.20989249
89cotranslational protein targeting to membrane (GO:0006613)3.20807083
90protein targeting to ER (GO:0045047)3.17369787
91protein localization to chromosome, centromeric region (GO:0071459)3.14801650
92ether lipid metabolic process (GO:0046485)3.14623667
93cell wall macromolecule catabolic process (GO:0016998)3.14525442
94positive regulation of phagocytosis (GO:0050766)3.14311509
95kinetochore organization (GO:0051383)3.12350848
96mitochondrial calcium ion transport (GO:0006851)3.11425398
97nucleobase-containing small molecule interconversion (GO:0015949)3.09328806
98cellular response to oxygen radical (GO:0071450)3.08789069
99removal of superoxide radicals (GO:0019430)3.08789069
100cellular response to superoxide (GO:0071451)3.08789069
101translational elongation (GO:0006414)3.07048389
102protein localization to endoplasmic reticulum (GO:0070972)3.05712842
103heme biosynthetic process (GO:0006783)3.05596281
104hydrogen peroxide metabolic process (GO:0042743)3.05254669
105autophagic vacuole fusion (GO:0000046)3.04059510
106nucleotide-excision repair, DNA gap filling (GO:0006297)3.02601455
107protoporphyrinogen IX metabolic process (GO:0046501)3.02150264
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99813494
109macrophage differentiation (GO:0030225)2.99331211
110pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99030600
111CENP-A containing nucleosome assembly (GO:0034080)2.96337350
112positive regulation of megakaryocyte differentiation (GO:0045654)2.95286055
113cellular protein complex disassembly (GO:0043624)2.95228530
114porphyrin-containing compound biosynthetic process (GO:0006779)2.92722342
115positive regulation of tumor necrosis factor production (GO:0032760)2.91448253
116regulation of B cell apoptotic process (GO:0002902)2.89608839
117sequestering of metal ion (GO:0051238)2.89570002
118purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88605763
119chromatin remodeling at centromere (GO:0031055)2.86871127
120positive regulation of histone H3-K4 methylation (GO:0051571)2.85473369
121transcription from mitochondrial promoter (GO:0006390)2.85275578
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84365401
123antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84365401
124cellular response to interferon-beta (GO:0035458)2.83405766
125Golgi transport vesicle coating (GO:0048200)2.81146381
126COPI coating of Golgi vesicle (GO:0048205)2.81146381
127positive regulation of granulocyte differentiation (GO:0030854)2.81090392
128intra-S DNA damage checkpoint (GO:0031573)2.78737762
129positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.78137659
130purine nucleobase metabolic process (GO:0006144)2.78077525
131ether metabolic process (GO:0018904)2.77584435
132positive regulation of chemokine production (GO:0032722)2.77534207
133response to food (GO:0032094)2.77348019
134kinetochore assembly (GO:0051382)2.77166978
135mannosylation (GO:0097502)2.74484116
136nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73581701
137viral life cycle (GO:0019058)2.70936267
138glycerol ether metabolic process (GO:0006662)2.66708122
139deoxyribonucleotide metabolic process (GO:0009262)2.66488446
140glucose catabolic process (GO:0006007)2.65318236
141mitotic nuclear envelope disassembly (GO:0007077)2.65094356
142skeletal muscle tissue regeneration (GO:0043403)2.64405147
143response to superoxide (GO:0000303)2.63263881
144leukocyte degranulation (GO:0043299)2.61184873
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60359179
146purine nucleobase biosynthetic process (GO:0009113)2.60122562
147negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.59259933
148negative regulation of myeloid cell apoptotic process (GO:0033033)2.57383951
149anterograde synaptic vesicle transport (GO:0048490)2.57187771
150response to oxygen radical (GO:0000305)2.56670942
151regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56160240
152leukocyte migration involved in inflammatory response (GO:0002523)2.56088586
153* cell killing (GO:0001906)2.55068715
154mast cell activation (GO:0045576)2.54887058
155response to peptidoglycan (GO:0032494)2.53238785
156pseudouridine synthesis (GO:0001522)2.51889412
157DNA topological change (GO:0006265)2.49806746
158viral transcription (GO:0019083)2.47251625
159cellular extravasation (GO:0045123)13.0631848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40650208
2MYB_21317192_ChIP-Seq_ERMYB_Mouse3.74642103
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72455619
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34899603
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31316641
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29038343
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.96758901
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.90277234
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79928755
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72521873
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.68821432
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.68811892
13* VDR_21846776_ChIP-Seq_THP-1_Human2.60903986
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51184590
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48740526
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.47215590
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41413261
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40147948
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35876450
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.19956192
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.15548006
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.13546043
23SPI1_23547873_ChIP-Seq_NB4_Human2.09629176
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09085433
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08885009
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08264734
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92922352
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92624152
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87422527
30FOXP3_21729870_ChIP-Seq_TREG_Human1.85870375
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85129589
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84117206
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83843118
34VDR_23849224_ChIP-Seq_CD4+_Human1.82566904
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82095653
36GATA1_22025678_ChIP-Seq_K562_Human1.81593578
37* VDR_24763502_ChIP-Seq_THP-1_Human1.78864433
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78611784
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77794501
40SCL_19346495_ChIP-Seq_HPC-7_Human1.77598360
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.76982051
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73283568
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70207956
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67131186
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66566445
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66447787
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64678649
48BCL6_27268052_Chip-Seq_Bcells_Human1.63652282
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61332360
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61008600
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60891446
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.59924549
53XRN2_22483619_ChIP-Seq_HELA_Human1.58182925
54MYC_22102868_ChIP-Seq_BL_Human1.56403398
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54715407
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54567558
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52904059
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.52676785
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.51438488
60MAF_26560356_Chip-Seq_TH2_Human1.49580171
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.49189670
62DCP1A_22483619_ChIP-Seq_HELA_Human1.48346042
63CIITA_25753668_ChIP-Seq_RAJI_Human1.47126269
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45821415
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45705692
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45323794
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45039382
68P68_20966046_ChIP-Seq_HELA_Human1.44473307
69GABP_19822575_ChIP-Seq_HepG2_Human1.42543944
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41933880
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41519582
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.41190334
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40341231
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39915615
75SPI1_20517297_ChIP-Seq_HL60_Human1.39774384
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39563538
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38623120
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38145983
79LXR_22292898_ChIP-Seq_THP-1_Human1.37688069
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.37054747
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30441853
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29855527
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29685071
84AR_21909140_ChIP-Seq_LNCAP_Human1.28890927
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28245870
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.28183947
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26702338
88TTF2_22483619_ChIP-Seq_HELA_Human1.26189381
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25678779
90MYB_26560356_Chip-Seq_TH2_Human1.25571398
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22910891
92BCOR_27268052_Chip-Seq_Bcells_Human1.21994702
93MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19442943
94E2F1_20622854_ChIP-Seq_HELA_Human1.19430252
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.19076346
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18672868
97ELK1_19687146_ChIP-ChIP_HELA_Human1.17842903
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16103110
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15543708
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.14489277
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13644373
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.13195409
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13012023
104RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11831740
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11698244
106MYB_26560356_Chip-Seq_TH1_Human1.11059591
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10741518
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10056968
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09820004
110SPI1_23127762_ChIP-Seq_K562_Human1.09754090
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08330609
112UTX_26944678_Chip-Seq_JUKART_Human1.07650259
113* FOXP1_21924763_ChIP-Seq_HESCs_Human1.07355365
114PHF8_20622854_ChIP-Seq_HELA_Human1.07283953
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06232885
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05427302
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05237658
118* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05149273
119TFEB_21752829_ChIP-Seq_HELA_Human1.05016478
120* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04070204
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03728134
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02084390
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02060993
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01624645
125STAT1_20625510_ChIP-Seq_HELA_Human1.01234298
126MAF_26560356_Chip-Seq_TH1_Human1.01039703
127* CTCF_26484167_Chip-Seq_Bcells_Mouse1.00376418
128* PU_27001747_Chip-Seq_BMDM_Mouse0.99085802
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98228191
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97129953
131* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94702400
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94588608
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93422811
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92458247
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90828441
136KDM5A_27292631_Chip-Seq_BREAST_Human0.89037726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.31869944
2MP0003693_abnormal_embryo_hatching3.69788801
3MP0003172_abnormal_lysosome_physiology3.38022298
4MP0002166_altered_tumor_susceptibility3.33675238
5MP0008057_abnormal_DNA_replication3.27836817
6MP0010094_abnormal_chromosome_stability3.06477839
7MP0003436_decreased_susceptibility_to3.05839335
8MP0003183_abnormal_peptide_metabolism2.98254432
9MP0009278_abnormal_bone_marrow2.76759019
10MP0003303_peritoneal_inflammation2.70814089
11* MP0002419_abnormal_innate_immunity2.69220995
12MP0005174_abnormal_tail_pigmentation2.67094997
13MP0003724_increased_susceptibility_to2.65936772
14MP0002006_tumorigenesis2.64777183
15MP0003111_abnormal_nucleus_morphology2.60098216
16MP0000569_abnormal_digit_pigmentation2.52333014
17MP0000490_abnormal_crypts_of2.47838430
18MP0005083_abnormal_biliary_tract2.37203943
19MP0006054_spinal_hemorrhage2.35650265
20MP0002009_preneoplasia2.28846949
21MP0001835_abnormal_antigen_presentation2.25324928
22MP0004185_abnormal_adipocyte_glucose2.21385297
23MP0003077_abnormal_cell_cycle2.20996966
24MP0002148_abnormal_hypersensitivity_rea2.17614852
25* MP0005025_abnormal_response_to2.16303094
26MP0004957_abnormal_blastocyst_morpholog2.15242247
27MP0005464_abnormal_platelet_physiology2.09976379
28MP0008058_abnormal_DNA_repair2.09423539
29MP0000858_altered_metastatic_potential1.99677416
30* MP0009785_altered_susceptibility_to1.95980291
31MP0005000_abnormal_immune_tolerance1.84738241
32MP0001545_abnormal_hematopoietic_system1.84143215
33MP0005397_hematopoietic_system_phenotyp1.84143215
34MP0000015_abnormal_ear_pigmentation1.83884795
35MP0005075_abnormal_melanosome_morpholog1.80703632
36* MP0002420_abnormal_adaptive_immunity1.73625019
37MP0000465_gastrointestinal_hemorrhage1.70266624
38* MP0001819_abnormal_immune_cell1.68510105
39MP0002822_catalepsy1.62920221
40MP0008877_abnormal_DNA_methylation1.58436158
41MP0003186_abnormal_redox_activity1.58332899
42MP0003763_abnormal_thymus_physiology1.57826107
43MP0009333_abnormal_splenocyte_physiolog1.55533461
44MP0002398_abnormal_bone_marrow1.51646763
45MP0001533_abnormal_skeleton_physiology1.50834938
46MP0000716_abnormal_immune_system1.50047779
47MP0005220_abnormal_exocrine_pancreas1.49949000
48MP0002095_abnormal_skin_pigmentation1.47835073
49MP0001853_heart_inflammation1.44465600
50MP0004808_abnormal_hematopoietic_stem1.44005408
51MP0002452_abnormal_antigen_presenting1.43710971
52MP0010155_abnormal_intestine_physiology1.43685296
53MP0002019_abnormal_tumor_incidence1.42640467
54MP0009379_abnormal_foot_pigmentation1.41570179
55MP0005671_abnormal_response_to1.41109297
56MP0010307_abnormal_tumor_latency1.40311357
57MP0000343_altered_response_to1.38818874
58MP0002429_abnormal_blood_cell1.37823862
59MP0002723_abnormal_immune_serum1.36845938
60MP0005058_abnormal_lysosome_morphology1.36572252
61MP0002722_abnormal_immune_system1.36277679
62MP0003656_abnormal_erythrocyte_physiolo1.35058722
63MP0008007_abnormal_cellular_replicative1.33443154
64MP0001663_abnormal_digestive_system1.32824948
65* MP0001845_abnormal_inflammatory_respons1.32267555
66MP0004264_abnormal_extraembryonic_tissu1.29362812
67MP0000689_abnormal_spleen_morphology1.28906818
68MP0003191_abnormal_cellular_cholesterol1.28880760
69MP0003866_abnormal_defecation1.27501020
70MP0008260_abnormal_autophagy1.23626630
71MP0005409_darkened_coat_color1.23592737
72MP0001800_abnormal_humoral_immune1.23488955
73MP0005076_abnormal_cell_differentiation1.23469343
74MP0005164_abnormal_response_to1.23155934
75MP0005666_abnormal_adipose_tissue1.22575974
76MP0003075_altered_response_to1.21710561
77MP0002405_respiratory_system_inflammati1.20627337
78MP0006036_abnormal_mitochondrial_physio1.19586921
79MP0002160_abnormal_reproductive_system1.19083124
80MP0004782_abnormal_surfactant_physiolog1.17470790
81MP0004742_abnormal_vestibular_system1.16213635
82MP0004147_increased_porphyrin_level1.12616411
83MP0001764_abnormal_homeostasis1.09434184
84MP0001986_abnormal_taste_sensitivity1.06841255
85MP0004130_abnormal_muscle_cell1.04469468
86MP0003638_abnormal_response/metabolism_1.03887724
87MP0008995_early_reproductive_senescence1.03475128
88MP0008961_abnormal_basal_metabolism1.03398668
89MP0003786_premature_aging1.03339030
90MP0008873_increased_physiological_sensi1.02951427
91MP0009764_decreased_sensitivity_to1.01484272
92MP0005266_abnormal_metabolism0.99967271
93MP0003221_abnormal_cardiomyocyte_apopto0.96387522
94MP0005360_urolithiasis0.95537323
95MP0000685_abnormal_immune_system0.95188574
96MP0008469_abnormal_protein_level0.94683874
97MP0003806_abnormal_nucleotide_metabolis0.94511728
98MP0000703_abnormal_thymus_morphology0.92846495
99MP0000372_irregular_coat_pigmentation0.92326188
100MP0000350_abnormal_cell_proliferation0.91435672
101MP0000249_abnormal_blood_vessel0.90132250
102MP0000358_abnormal_cell_content/0.89760744
103MP0002971_abnormal_brown_adipose0.88839399
104MP0003121_genomic_imprinting0.88546684
105MP0000313_abnormal_cell_death0.87478678
106MP0008932_abnormal_embryonic_tissue0.87330832
107MP0009763_increased_sensitivity_to0.87222632
108MP0001873_stomach_inflammation0.87154471
109MP0001851_eye_inflammation0.86458658
110MP0005376_homeostasis/metabolism_phenot0.85923948
111MP0005451_abnormal_body_composition0.82558337
112MP0003123_paternal_imprinting0.81541088
113MP0005535_abnormal_body_temperature0.78646128
114MP0003787_abnormal_imprinting0.76516368
115MP0009697_abnormal_copulation0.76040136
116MP0002735_abnormal_chemical_nociception0.73770724
117MP0005381_digestive/alimentary_phenotyp0.73369931
118MP0005389_reproductive_system_phenotype0.73323954
119MP0005584_abnormal_enzyme/coenzyme_acti0.71819166
120MP0000598_abnormal_liver_morphology0.71785507
121MP0004381_abnormal_hair_follicle0.70189057
122MP0005334_abnormal_fat_pad0.68079240
123MP0001730_embryonic_growth_arrest0.67703814
124MP0010352_gastrointestinal_tract_polyps0.67546782
125MP0005375_adipose_tissue_phenotype0.67003272
126MP0006035_abnormal_mitochondrial_morpho0.66952294
127MP0005387_immune_system_phenotype0.66931043
128MP0001790_abnormal_immune_system0.66931043
129MP0009765_abnormal_xenobiotic_induced0.66563368
130MP0005165_increased_susceptibility_to0.65947949
131MP0003718_maternal_effect0.64409328
132MP0005384_cellular_phenotype0.63600469
133MP0010329_abnormal_lipoprotein_level0.63346057
134MP0005319_abnormal_enzyme/_coenzyme0.61758827
135MP0005670_abnormal_white_adipose0.60694391
136MP0002970_abnormal_white_adipose0.60407198
137MP0009672_abnormal_birth_weight0.60149755
138MP0009053_abnormal_anal_canal0.58871611
139MP0000371_diluted_coat_color0.57343463

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the prostate (HP:0008775)5.87210746
2Obstructive lung disease (HP:0006536)5.69887986
3Chronic obstructive pulmonary disease (HP:0006510)5.69887986
4Reduced antithrombin III activity (HP:0001976)4.74006992
5Chest pain (HP:0100749)4.62550888
6Type I transferrin isoform profile (HP:0003642)4.46773218
7Agammaglobulinemia (HP:0004432)4.44543197
8Recurrent abscess formation (HP:0002722)4.43640861
9Papilledema (HP:0001085)4.21979378
10Recurrent bacterial skin infections (HP:0005406)4.19270294
11Ureteral stenosis (HP:0000071)4.15559899
12Elevated erythrocyte sedimentation rate (HP:0003565)3.90313088
13Abnormal number of erythroid precursors (HP:0012131)3.78849086
14* Thrombocytosis (HP:0001894)3.78651707
15Pulmonary fibrosis (HP:0002206)3.70660991
16Eczematoid dermatitis (HP:0000976)3.67298670
17Ureteral obstruction (HP:0006000)3.63285021
18Gangrene (HP:0100758)3.61345071
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.59239106
20Myositis (HP:0100614)3.55272724
21Aplastic anemia (HP:0001915)3.52148962
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.47061258
23Abnormal protein N-linked glycosylation (HP:0012347)3.47061258
24Abnormal protein glycosylation (HP:0012346)3.47061258
25Abnormal glycosylation (HP:0012345)3.47061258
26Abnormality of cells of the erythroid lineage (HP:0012130)3.46884601
27Loss of speech (HP:0002371)3.45546034
28Reticulocytopenia (HP:0001896)3.44129528
29Meningitis (HP:0001287)3.42901494
30Pulmonary infiltrates (HP:0002113)3.35988503
31Acute lymphatic leukemia (HP:0006721)3.35328873
32Hemoptysis (HP:0002105)3.33157091
33Abnormality of the pleura (HP:0002103)3.12294007
34Abnormality of B cell number (HP:0010975)3.10623268
35B lymphocytopenia (HP:0010976)3.10623268
36Dysostosis multiplex (HP:0000943)3.08969710
37Poikiloderma (HP:0001029)3.07930510
38Acute myeloid leukemia (HP:0004808)2.98525196
39Abnormality of male internal genitalia (HP:0000022)2.95540161
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.91862741
41Abnormality of T cell physiology (HP:0011840)2.80677080
42Recurrent gram-negative bacterial infections (HP:0005420)2.77257149
43Petechiae (HP:0000967)2.67225901
44Epistaxis (HP:0000421)2.64702823
45Vasculitis (HP:0002633)2.63785220
46Spondylolisthesis (HP:0003302)2.62616776
47IgM deficiency (HP:0002850)2.60917980
48Agnosia (HP:0010524)2.56884772
49Gastrointestinal infarctions (HP:0005244)2.56585223
50Generalized aminoaciduria (HP:0002909)2.53046469
51Restrictive lung disease (HP:0002091)2.50912827
52Thrombophlebitis (HP:0004418)2.49724560
53Oral leukoplakia (HP:0002745)2.48504506
54Hepatosplenomegaly (HP:0001433)2.45786461
55Cutaneous melanoma (HP:0012056)2.45482272
56Glomerulopathy (HP:0100820)2.44531616
57Mediastinal lymphadenopathy (HP:0100721)2.43268808
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40661710
59Increased cerebral lipofuscin (HP:0011813)2.39637794
60Pulmonary embolism (HP:0002204)2.38843554
61Increased muscle lipid content (HP:0009058)2.38650114
62Mitochondrial inheritance (HP:0001427)2.36462062
63Recurrent skin infections (HP:0001581)2.35300081
64Entropion (HP:0000621)2.34929428
65Degeneration of anterior horn cells (HP:0002398)2.34362522
66Abnormality of the anterior horn cell (HP:0006802)2.34362522
67Renal Fanconi syndrome (HP:0001994)2.31739289
68Polyneuropathy (HP:0001271)2.31673661
69Chromsome breakage (HP:0040012)2.31619724
70Hepatic necrosis (HP:0002605)2.29909805
7111 pairs of ribs (HP:0000878)2.29244658
72Bone marrow hypocellularity (HP:0005528)2.28020314
73Abnormality of macrophages (HP:0004311)2.26636138
74Amaurosis fugax (HP:0100576)2.26232793
75Skin rash (HP:0000988)2.23031703
76Large eyes (HP:0001090)2.21607143
77Abnormality of the pericardium (HP:0001697)2.20949518
78Orchitis (HP:0100796)2.18559910
79Severe visual impairment (HP:0001141)2.18525109
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18195873
81Abnormality of polysaccharide metabolism (HP:0011012)2.18195873
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18195873
83Hypochromic microcytic anemia (HP:0004840)2.17672950
84Asymmetric septal hypertrophy (HP:0001670)2.16803746
85Chronic otitis media (HP:0000389)2.16372577
86J-shaped sella turcica (HP:0002680)2.15993718
87Lipid accumulation in hepatocytes (HP:0006561)2.12866236
88Pancytopenia (HP:0001876)2.12265679
89Abnormality of DNA repair (HP:0003254)2.12047858
90Urinary glycosaminoglycan excretion (HP:0003541)2.09925268
91Mucopolysacchariduria (HP:0008155)2.09925268
92Microcytic anemia (HP:0001935)2.08507474
93Abnormality of the thoracic spine (HP:0100711)2.08216825
94Myelodysplasia (HP:0002863)2.07826418
95Increased serum ferritin (HP:0003281)2.06151801
96Abnormality of iron homeostasis (HP:0011031)2.05711412
97Gingivitis (HP:0000230)2.05370898
98Duplicated collecting system (HP:0000081)2.04351727
99Pallor (HP:0000980)2.04153959
100Joint stiffness (HP:0001387)2.01343319
101Poor head control (HP:0002421)2.00676629
102Amyloidosis (HP:0011034)1.98967697
103Microvesicular hepatic steatosis (HP:0001414)1.98673587
104Paralysis (HP:0003470)1.98662294
105Increased intramyocellular lipid droplets (HP:0012240)1.97678649
106Premature graying of hair (HP:0002216)1.97132374
107Facial edema (HP:0000282)1.96313464
108Nonimmune hydrops fetalis (HP:0001790)1.96016743
109Abnormality of chromosome stability (HP:0003220)1.95669751
110Paresthesia (HP:0003401)1.95441123
111Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94942656
112* Skin ulcer (HP:0200042)1.94567067
113Keratoconjunctivitis sicca (HP:0001097)1.94153699
114Increased CSF lactate (HP:0002490)1.93241662
115Recurrent fungal infections (HP:0002841)1.91526233
116Thoracic kyphosis (HP:0002942)1.91396762
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91231485
118Dicarboxylic aciduria (HP:0003215)1.91231485
119Hypoplasia of the thymus (HP:0000778)1.90883453
120* Neutropenia (HP:0001875)1.90565993
121Cellulitis (HP:0100658)1.89494815
122Recurrent pneumonia (HP:0006532)1.89243792
123Vacuolated lymphocytes (HP:0001922)1.88796528
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.88086167
125Osteomyelitis (HP:0002754)1.87944264
126Hypermelanotic macule (HP:0001034)1.87319100
127Periorbital edema (HP:0100539)1.87042398
128Abnormality of transition element cation homeostasis (HP:0011030)1.86751967
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86655655
130Hypochromic anemia (HP:0001931)1.85900726
131Joint hemorrhage (HP:0005261)1.85580437
132Recurrent cutaneous fungal infections (HP:0011370)1.85335195
133Chronic mucocutaneous candidiasis (HP:0002728)1.85335195
134Hepatocellular necrosis (HP:0001404)1.84187977
135Nausea (HP:0002018)1.83466658
136Ureteral duplication (HP:0000073)1.82687760
137Rhabdomyolysis (HP:0003201)1.81449196
138Abnormality of pyrimidine metabolism (HP:0004353)1.81275171
139Pancreatitis (HP:0001733)1.80442946
140Spontaneous hematomas (HP:0007420)1.79700242
141Recurrent viral infections (HP:0004429)1.79133305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.06114458
2EIF2AK34.05575294
3IRAK43.81930180
4VRK23.57377892
5MAP3K122.99047821
6NUAK12.59075482
7TESK12.51380794
8WEE12.46269818
9TNK22.39929569
10BUB12.35560105
11CDC72.35259336
12ARAF2.33364370
13TAOK32.28258257
14TEC2.22526936
15CDK122.12520709
16VRK12.12237967
17ERN12.09643465
18TESK21.93830434
19PIM21.92030810
20FES1.81157819
21BLK1.73816872
22BTK1.65099032
23MAP2K31.62829499
24CCNB11.61885897
25TBK11.61548220
26SRPK11.58029100
27BMPR21.57982978
28ABL21.49370814
29LIMK11.48262225
30DAPK11.48160750
31EIF2AK11.47761608
32CLK11.45983635
33BRSK21.42818916
34TSSK61.38365020
35IRAK31.33035471
36MYLK1.27415333
37ATR1.25050450
38EIF2AK21.24398927
39MAP3K61.21787518
40EEF2K1.21324194
41RPS6KC11.20586512
42RPS6KL11.20586512
43CDK61.17437198
44CDK71.17144207
45PAK41.16692969
46MAP4K11.15102595
47CDK81.12683679
48SYK1.12412904
49RPS6KA61.08586938
50MKNK11.08519734
51RPS6KA21.08138046
52MAP3K141.05083193
53RPS6KB11.04435824
54MAP4K21.03795940
55RPS6KA41.03284584
56ZAP701.01113109
57RIPK40.99578998
58TNIK0.99436320
59PLK40.97157453
60KIT0.96980124
61CAMKK20.96956015
62SCYL20.96752940
63CDK30.95904936
64MAP3K110.95451267
65PASK0.95215997
66MAPK40.93815979
67FLT30.93123458
68PIK3CG0.91894639
69CDK190.91703050
70NEK20.88404652
71MAP3K80.87787952
72MKNK20.86589180
73MAP2K60.85349192
74BRSK10.83962639
75AURKB0.79749704
76IKBKB0.79232703
77CDK40.78267565
78PRPF4B0.77976677
79RPS6KB20.77783420
80PLK10.77668964
81TRPM70.74713361
82HIPK20.74434190
83PLK30.74211101
84ILK0.74065307
85BCKDK0.73344689
86TAOK10.69723453
87PIK3CA0.69370158
88PIM10.69166998
89NEK10.67768339
90TXK0.67624881
91ITK0.67241099
92GRK70.66885861
93STK40.66340309
94GRK60.63426334
95TYK20.62496791
96LYN0.61186581
97BRAF0.60483811
98RPS6KA50.59614368
99LCK0.59545017
100TLK10.59101528
101CSF1R0.58732568
102TTK0.56044634
103TGFBR20.55194973
104KDR0.54370240
105ICK0.54286206
106LATS10.54232836
107CHEK20.54071065
108JAK10.52257900
109RAF10.52030386
110LRRK20.51739949
111PAK10.50180683
112ZAK0.50045230
113MATK0.49374425
114PRKCD0.48064463
115NME20.47161336
116PKN20.46614367
117PRKCQ0.44698198
118GRK50.44404963
119CSNK2A20.42985831
120HCK0.42746340
121CHEK10.41996338
122PTK2B0.41676929
123JAK30.41418795
124JAK20.40895923
125TRIM280.40497684
126CSNK2A10.40094660
127AURKA0.39710675
128GSK3A0.39199122
129STK100.39104386
130MAPK110.38558183
131MAPKAPK30.35579101
132PRKCI0.35156597
133IKBKE0.34486405
134DYRK20.34322844
135CAMK1D0.34076875
136AKT10.31512927
137MOS0.30910311
138MAP2K40.30885126
139INSRR0.29830392
140PDPK10.29718412
141PDK10.26936361
142CDK90.26657832
143MAPKAPK50.26285928

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01399632
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.19071929
3Protein export_Homo sapiens_hsa030603.56812413
4Mismatch repair_Homo sapiens_hsa034303.36980864
5Base excision repair_Homo sapiens_hsa034103.15589648
6Homologous recombination_Homo sapiens_hsa034402.82238181
7Ribosome_Homo sapiens_hsa030102.58367532
8Pentose phosphate pathway_Homo sapiens_hsa000302.55751159
9N-Glycan biosynthesis_Homo sapiens_hsa005102.49820868
10Non-homologous end-joining_Homo sapiens_hsa034502.34069996
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.30425690
12Nucleotide excision repair_Homo sapiens_hsa034202.14408948
13Renin-angiotensin system_Homo sapiens_hsa046142.04546989
14Oxidative phosphorylation_Homo sapiens_hsa001902.04213606
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85739101
16One carbon pool by folate_Homo sapiens_hsa006701.78937078
17Galactose metabolism_Homo sapiens_hsa000521.78404305
18Fanconi anemia pathway_Homo sapiens_hsa034601.75849155
19Glutathione metabolism_Homo sapiens_hsa004801.72947578
20Spliceosome_Homo sapiens_hsa030401.71349890
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67867511
22Proteasome_Homo sapiens_hsa030501.67690177
23Pyrimidine metabolism_Homo sapiens_hsa002401.65026722
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.60848713
25Other glycan degradation_Homo sapiens_hsa005111.57869992
26Leishmaniasis_Homo sapiens_hsa051401.56481262
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53197173
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51546283
29Staphylococcus aureus infection_Homo sapiens_hsa051501.44558326
30Cell cycle_Homo sapiens_hsa041101.43847964
31RNA polymerase_Homo sapiens_hsa030201.37205637
32* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35515331
33Acute myeloid leukemia_Homo sapiens_hsa052211.30831380
34RNA transport_Homo sapiens_hsa030131.29567353
35Starch and sucrose metabolism_Homo sapiens_hsa005001.25878871
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23769887
37Huntingtons disease_Homo sapiens_hsa050161.21289771
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18771937
39Phagosome_Homo sapiens_hsa041451.14647421
40Fructose and mannose metabolism_Homo sapiens_hsa000511.12969807
41RNA degradation_Homo sapiens_hsa030181.11946009
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11849283
43Malaria_Homo sapiens_hsa051441.08038443
44Alzheimers disease_Homo sapiens_hsa050101.07429659
45Antigen processing and presentation_Homo sapiens_hsa046121.06763185
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01537188
47Purine metabolism_Homo sapiens_hsa002301.00804722
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98157516
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97015819
50Amoebiasis_Homo sapiens_hsa051460.95694020
51Hematopoietic cell lineage_Homo sapiens_hsa046400.91433268
52Biosynthesis of amino acids_Homo sapiens_hsa012300.88795802
53Lysosome_Homo sapiens_hsa041420.87529608
54Carbon metabolism_Homo sapiens_hsa012000.86221321
55African trypanosomiasis_Homo sapiens_hsa051430.83041268
56Regulation of autophagy_Homo sapiens_hsa041400.82017730
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81705528
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80448715
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79386854
60Sulfur metabolism_Homo sapiens_hsa009200.77943620
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74610624
62Platelet activation_Homo sapiens_hsa046110.73255692
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.72840116
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72372747
65Legionellosis_Homo sapiens_hsa051340.71207102
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70881251
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69650605
68Ether lipid metabolism_Homo sapiens_hsa005650.69632706
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68436459
70Herpes simplex infection_Homo sapiens_hsa051680.67549994
71Non-small cell lung cancer_Homo sapiens_hsa052230.67441549
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.67143892
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67005346
74p53 signaling pathway_Homo sapiens_hsa041150.65438288
75Arachidonic acid metabolism_Homo sapiens_hsa005900.64677958
76Autoimmune thyroid disease_Homo sapiens_hsa053200.64138939
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63975775
78Cardiac muscle contraction_Homo sapiens_hsa042600.61044116
79Pertussis_Homo sapiens_hsa051330.57108896
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.56615765
81Allograft rejection_Homo sapiens_hsa053300.56554107
82Basal transcription factors_Homo sapiens_hsa030220.56183785
83Selenocompound metabolism_Homo sapiens_hsa004500.55570772
84Phenylalanine metabolism_Homo sapiens_hsa003600.55328447
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54590741
86Histidine metabolism_Homo sapiens_hsa003400.54448310
87Vitamin B6 metabolism_Homo sapiens_hsa007500.54288444
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.52393555
89Thyroid hormone synthesis_Homo sapiens_hsa049180.52074168
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51787434
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50304364
92* Systemic lupus erythematosus_Homo sapiens_hsa053220.50229648
93Primary immunodeficiency_Homo sapiens_hsa053400.49501998
94Osteoclast differentiation_Homo sapiens_hsa043800.48504258
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.47567457
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.47522517
97Peroxisome_Homo sapiens_hsa041460.46140426
98Measles_Homo sapiens_hsa051620.45783984
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44861237
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42869248
101Metabolic pathways_Homo sapiens_hsa011000.42820074
102Graft-versus-host disease_Homo sapiens_hsa053320.41939747
103Asthma_Homo sapiens_hsa053100.40938003
104Salivary secretion_Homo sapiens_hsa049700.39761497
105Thyroid cancer_Homo sapiens_hsa052160.39732100
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38641995
107Tuberculosis_Homo sapiens_hsa051520.38626976
108Tryptophan metabolism_Homo sapiens_hsa003800.37450800
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36388543
110Apoptosis_Homo sapiens_hsa042100.34981611
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34562439
112Tyrosine metabolism_Homo sapiens_hsa003500.34205492
113Glycerolipid metabolism_Homo sapiens_hsa005610.34145113
114Salmonella infection_Homo sapiens_hsa051320.34007366
115VEGF signaling pathway_Homo sapiens_hsa043700.33202079
116Influenza A_Homo sapiens_hsa051640.32154654
117Butanoate metabolism_Homo sapiens_hsa006500.32082298
118Epstein-Barr virus infection_Homo sapiens_hsa051690.32000774
119Fatty acid metabolism_Homo sapiens_hsa012120.31582320
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31229036
121Rheumatoid arthritis_Homo sapiens_hsa053230.30401719
122Folate biosynthesis_Homo sapiens_hsa007900.29630615
123Sulfur relay system_Homo sapiens_hsa041220.29081198
124mTOR signaling pathway_Homo sapiens_hsa041500.28667386
125Sphingolipid metabolism_Homo sapiens_hsa006000.28347868
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28132972
127Parkinsons disease_Homo sapiens_hsa050120.28077811
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.27759220
129Fatty acid elongation_Homo sapiens_hsa000620.27628371
130Pancreatic secretion_Homo sapiens_hsa049720.27582241
131Fatty acid degradation_Homo sapiens_hsa000710.26834198
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26117350
133ABC transporters_Homo sapiens_hsa020100.25947926
134Type I diabetes mellitus_Homo sapiens_hsa049400.24991631
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24713773
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24710761
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24272585
138Shigellosis_Homo sapiens_hsa051310.22499903
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22109680
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.21390617
141B cell receptor signaling pathway_Homo sapiens_hsa046620.20547998
142Viral carcinogenesis_Homo sapiens_hsa052030.20027651

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