ELAVL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)5.32585061
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.32585061
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.32585061
4regulation of sister chromatid cohesion (GO:0007063)5.20075288
5positive regulation of chromosome segregation (GO:0051984)4.93441905
6DNA unwinding involved in DNA replication (GO:0006268)4.78618444
7DNA strand elongation involved in DNA replication (GO:0006271)4.75924305
8folic acid-containing compound biosynthetic process (GO:0009396)4.61614706
9DNA strand elongation (GO:0022616)4.53169887
10DNA replication initiation (GO:0006270)4.51410956
11telomere maintenance via semi-conservative replication (GO:0032201)4.46889401
12negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.36356125
13kinetochore organization (GO:0051383)4.19474940
14DNA replication checkpoint (GO:0000076)4.07568197
15telomere maintenance via recombination (GO:0000722)4.01058913
16CENP-A containing nucleosome assembly (GO:0034080)4.00604262
17chromatin remodeling at centromere (GO:0031055)3.98735533
18mitotic recombination (GO:0006312)3.94476004
19positive regulation of cell size (GO:0045793)3.92666025
20nuclear pore complex assembly (GO:0051292)3.90488125
21protein localization to kinetochore (GO:0034501)3.90109133
22nuclear pore organization (GO:0006999)3.89978112
23heterochromatin organization (GO:0070828)3.80457889
24peptidyl-lysine dimethylation (GO:0018027)3.79892864
25regulation of mammary gland epithelial cell proliferation (GO:0033599)3.78115909
26non-recombinational repair (GO:0000726)3.76228693
27double-strand break repair via nonhomologous end joining (GO:0006303)3.76228693
28kinetochore assembly (GO:0051382)3.72423454
29pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.70218309
30mitotic metaphase plate congression (GO:0007080)3.70010071
31pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.69214751
32telomere maintenance via telomere lengthening (GO:0010833)3.68842523
33mitotic nuclear envelope disassembly (GO:0007077)3.68542926
34cellular protein complex localization (GO:0034629)3.68386548
35pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.67186146
36ribosomal small subunit assembly (GO:0000028)3.66326154
37DNA replication-independent nucleosome organization (GO:0034724)3.65536162
38DNA replication-independent nucleosome assembly (GO:0006336)3.65536162
39pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.58387909
40IMP biosynthetic process (GO:0006188)3.58000652
41protein complex localization (GO:0031503)3.56691498
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.55000880
43protein localization to chromosome, centromeric region (GO:0071459)3.53879203
44peptidyl-arginine omega-N-methylation (GO:0035247)3.53518634
45DNA replication-dependent nucleosome assembly (GO:0006335)3.52281677
46DNA replication-dependent nucleosome organization (GO:0034723)3.52281677
47negative regulation of Ras GTPase activity (GO:0034261)3.45791876
48DNA deamination (GO:0045006)3.43086190
49membrane disassembly (GO:0030397)3.40634604
50nuclear envelope disassembly (GO:0051081)3.40634604
51formation of translation preinitiation complex (GO:0001731)3.38719755
52nucleobase biosynthetic process (GO:0046112)3.38653412
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.37800486
54establishment of mitotic spindle localization (GO:0040001)3.34707919
55positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.33853402
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31771703
57metaphase plate congression (GO:0051310)3.30578559
58chromatin assembly (GO:0031497)3.28955424
59histone exchange (GO:0043486)3.28477834
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27663290
61maturation of SSU-rRNA (GO:0030490)3.27168571
62negative regulation of T cell receptor signaling pathway (GO:0050860)3.25451805
63mitotic chromosome condensation (GO:0007076)3.25390277
64pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.24683851
65regulation of mitochondrial translation (GO:0070129)3.23441139
66purine nucleobase biosynthetic process (GO:0009113)3.23299093
67mitochondrial RNA metabolic process (GO:0000959)3.22106169
68establishment of chromosome localization (GO:0051303)3.20791572
69ribosomal small subunit biogenesis (GO:0042274)3.20705735
70attachment of spindle microtubules to kinetochore (GO:0008608)3.16643615
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14965470
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.13845602
73diaphragm development (GO:0060539)3.12711157
74protein-DNA complex disassembly (GO:0032986)3.12197278
75nucleosome disassembly (GO:0006337)3.12197278
76DNA topological change (GO:0006265)3.12036553
77L-serine metabolic process (GO:0006563)3.11962103
78establishment of mitotic spindle orientation (GO:0000132)3.10233196
79ATP-dependent chromatin remodeling (GO:0043044)3.08647919
80viral mRNA export from host cell nucleus (GO:0046784)3.08554173
81CTP metabolic process (GO:0046036)3.07901353
82CTP biosynthetic process (GO:0006241)3.07901353
83IMP metabolic process (GO:0046040)3.06730819
84regulation of translational fidelity (GO:0006450)3.06698635
85mitotic sister chromatid segregation (GO:0000070)3.06112019
86chromatin silencing (GO:0006342)3.05044501
87histone arginine methylation (GO:0034969)3.04581732
88skeletal muscle organ development (GO:0060538)3.04528452
89spliceosomal snRNP assembly (GO:0000387)3.04268662
90DNA duplex unwinding (GO:0032508)3.03772660
91sister chromatid segregation (GO:0000819)3.03555034
92DNA geometric change (GO:0032392)3.03554832
93pore complex assembly (GO:0046931)3.03040727
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.02239962
95translesion synthesis (GO:0019985)3.01522846
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99755994
97negative regulation of sister chromatid segregation (GO:0033046)2.99755994
98negative regulation of mitotic sister chromatid separation (GO:2000816)2.99755994
99negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99755994
100mismatch repair (GO:0006298)2.99308828
101negative regulation of RNA splicing (GO:0033119)2.98139976
102meiotic chromosome segregation (GO:0045132)2.97986106
103negative regulation of chromosome segregation (GO:0051985)2.97532845
104regulation of double-strand break repair via homologous recombination (GO:0010569)2.95141330
105histone H2A acetylation (GO:0043968)2.94206825
106spindle checkpoint (GO:0031577)2.94030816
107RNA splicing, via transesterification reactions (GO:0000375)2.93882143
108spindle assembly checkpoint (GO:0071173)2.92899528
109chromatin assembly or disassembly (GO:0006333)2.92879929
110ribosome biogenesis (GO:0042254)2.92757941
111termination of RNA polymerase II transcription (GO:0006369)2.92533552
112telomere maintenance (GO:0000723)2.92217996
113RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.92091682
114mRNA splicing, via spliceosome (GO:0000398)2.92091682
115dosage compensation (GO:0007549)2.91454252
116telomere organization (GO:0032200)2.91245778
117mitotic spindle assembly checkpoint (GO:0007094)2.90317624
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89664027
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89455939
120regulation of helicase activity (GO:0051095)2.89362247
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88994750
122ncRNA 3-end processing (GO:0043628)2.88648349
123positive regulation of receptor biosynthetic process (GO:0010870)2.88300252
124regulation of spindle organization (GO:0090224)2.87607813
125establishment of integrated proviral latency (GO:0075713)2.84644275
126tetrahydrofolate metabolic process (GO:0046653)2.84443857
127pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.84397292
128UMP biosynthetic process (GO:0006222)2.84397292
129pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.84397292
130UMP metabolic process (GO:0046049)2.84397292
131mitotic spindle checkpoint (GO:0071174)2.84346707
132histone mRNA metabolic process (GO:0008334)2.83356928
133spliceosomal complex assembly (GO:0000245)2.82905330
134peptidyl-arginine N-methylation (GO:0035246)2.82596693
135peptidyl-arginine methylation (GO:0018216)2.82596693
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82346717
137regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81577884
138regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.81502468
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.80706579
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80706579
141postreplication repair (GO:0006301)2.80599414
142transcription-coupled nucleotide-excision repair (GO:0006283)2.79476431
143regulation of chromosome segregation (GO:0051983)2.79443038
144negative regulation of mRNA processing (GO:0050686)2.76718928
145negative regulation of gene expression, epigenetic (GO:0045814)2.76354534
146protein prenylation (GO:0018342)2.76265838
147prenylation (GO:0097354)2.76265838
148intra-S DNA damage checkpoint (GO:0031573)2.76034456
149deoxyribonucleotide biosynthetic process (GO:0009263)2.75189498
150DNA ligation (GO:0006266)2.74386943
151regulation of sister chromatid segregation (GO:0033045)2.73804180
152regulation of mitotic sister chromatid separation (GO:0010965)2.73804180
153regulation of mitotic sister chromatid segregation (GO:0033047)2.73804180
154ribonucleoprotein complex biogenesis (GO:0022613)2.73303107
155rRNA processing (GO:0006364)2.71237320
156organ growth (GO:0035265)2.69529427
157pyrimidine nucleotide biosynthetic process (GO:0006221)2.67270796
158establishment of spindle localization (GO:0051293)2.66216124
159histone H3-K9 methylation (GO:0051567)2.66026070
160establishment of spindle orientation (GO:0051294)2.65625635
161adenine nucleotide transport (GO:0051503)2.63121805
162coenzyme A biosynthetic process (GO:0015937)2.60422597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.31479501
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26304653
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17455343
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47108430
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34977550
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96824162
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86804855
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86747547
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.70560889
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.62917867
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62426983
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.50847714
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49600149
14EZH2_22144423_ChIP-Seq_EOC_Human2.49462134
15XRN2_22483619_ChIP-Seq_HELA_Human2.36149756
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35660610
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.33099568
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32289375
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.30354409
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28911064
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28335585
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28133170
23VDR_23849224_ChIP-Seq_CD4+_Human2.15975855
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14632970
25AR_21909140_ChIP-Seq_LNCAP_Human2.14109574
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13233802
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09056481
28E2F7_22180533_ChIP-Seq_HELA_Human10.0771205
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98643309
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.92753262
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91519410
32ELK1_19687146_ChIP-ChIP_HELA_Human1.91504948
33DCP1A_22483619_ChIP-Seq_HELA_Human1.90008777
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88704118
35ZNF263_19887448_ChIP-Seq_K562_Human1.88351239
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87972208
37GATA1_22025678_ChIP-Seq_K562_Human1.86496953
38TTF2_22483619_ChIP-Seq_HELA_Human1.85778860
39FOXP3_21729870_ChIP-Seq_TREG_Human1.84268548
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82669625
41MYC_22102868_ChIP-Seq_BL_Human1.79611082
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75174560
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71182461
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69944914
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69861466
46GABP_19822575_ChIP-Seq_HepG2_Human1.69202551
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63483017
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62945698
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62811776
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62323600
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59069045
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57821297
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55903579
54CIITA_25753668_ChIP-Seq_RAJI_Human1.54516864
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53984248
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46825763
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46086377
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42545642
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42537369
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40884037
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35642665
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35451151
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29867283
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28726914
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27450847
66KDM5A_27292631_Chip-Seq_BREAST_Human1.27268323
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26899819
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.25134376
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23850014
70* YY1_21170310_ChIP-Seq_MESCs_Mouse1.21449958
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20736487
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19454701
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.18864911
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18109498
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17892657
76LXR_22292898_ChIP-Seq_THP-1_Human1.16185069
77TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16086178
78P68_20966046_ChIP-Seq_HELA_Human1.15906655
79TFEB_21752829_ChIP-Seq_HELA_Human1.14638516
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14163028
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12697651
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.12451652
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11584931
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.09502032
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08824569
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08164777
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07468463
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07468463
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07468463
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06803974
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02944934
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02898306
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02616667
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01596183
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99402068
96MYC_18940864_ChIP-ChIP_HL60_Human0.98815167
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98354916
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97018705
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96513823
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.96323959
101CTCF_21964334_Chip-Seq_Bcells_Human0.95977896
102* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94994135
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94606905
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93005932
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92896206
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92689254
107SPI1_23547873_ChIP-Seq_NB4_Human0.90715764
108VDR_21846776_ChIP-Seq_THP-1_Human0.90183191
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89205364
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89169427
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89022690
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88306250
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85772745
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.84593546
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84530803
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84035521
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.83408387
118KAP1_27257070_Chip-Seq_ESCs_Mouse0.83002654
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82497169
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82308753
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81562227
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.81231173
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80620321
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80119879
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79424845
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78184640
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.77874502
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77602505
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76584450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41577945
2MP0010094_abnormal_chromosome_stability4.29247361
3MP0003111_abnormal_nucleus_morphology3.82400240
4MP0004957_abnormal_blastocyst_morpholog3.75137436
5MP0008057_abnormal_DNA_replication3.66375751
6MP0003077_abnormal_cell_cycle3.59674878
7MP0008007_abnormal_cellular_replicative3.19102936
8MP0003123_paternal_imprinting3.13422601
9MP0002234_abnormal_pharynx_morphology3.12061712
10MP0008058_abnormal_DNA_repair2.86451714
11MP0004858_abnormal_nervous_system2.74528313
12MP0008932_abnormal_embryonic_tissue2.46453489
13MP0004233_abnormal_muscle_weight2.44597343
14MP0000467_abnormal_esophagus_morphology2.25942089
15MP0002396_abnormal_hematopoietic_system2.24534165
16MP0001919_abnormal_reproductive_system2.21155637
17MP0002009_preneoplasia2.13914697
18* MP0000350_abnormal_cell_proliferation2.12920848
19MP0003646_muscle_fatigue2.06910152
20MP0005645_abnormal_hypothalamus_physiol2.03961492
21MP0010352_gastrointestinal_tract_polyps2.03557583
22MP0001730_embryonic_growth_arrest2.03287152
23MP0003121_genomic_imprinting1.94563854
24MP0010030_abnormal_orbit_morphology1.77306376
25MP0008877_abnormal_DNA_methylation1.73362282
26MP0004197_abnormal_fetal_growth/weight/1.66328154
27MP0001697_abnormal_embryo_size1.64628420
28MP0000534_abnormal_ureter_morphology1.64343887
29* MP0001672_abnormal_embryogenesis/_devel1.61641286
30* MP0005380_embryogenesis_phenotype1.61641286
31* MP0000490_abnormal_crypts_of1.60704357
32MP0003567_abnormal_fetal_cardiomyocyte1.58699696
33MP0003890_abnormal_embryonic-extraembry1.57452381
34MP0003315_abnormal_perineum_morphology1.54372089
35MP0004808_abnormal_hematopoietic_stem1.51103383
36MP0003786_premature_aging1.50693563
37* MP0002085_abnormal_embryonic_tissue1.49985342
38MP0001346_abnormal_lacrimal_gland1.48333239
39* MP0003984_embryonic_growth_retardation1.47342603
40* MP0002088_abnormal_embryonic_growth/wei1.44882751
41MP0002084_abnormal_developmental_patter1.42246106
42* MP0002080_prenatal_lethality1.37134797
43MP0000537_abnormal_urethra_morphology1.36760786
44MP0002249_abnormal_larynx_morphology1.34057336
45MP0005076_abnormal_cell_differentiation1.33712011
46* MP0000313_abnormal_cell_death1.33678407
47MP0009053_abnormal_anal_canal1.31484401
48MP0001293_anophthalmia1.30846350
49MP0003941_abnormal_skin_development1.30831630
50* MP0002086_abnormal_extraembryonic_tissu1.28650163
51MP0003119_abnormal_digestive_system1.27571938
52MP0002877_abnormal_melanocyte_morpholog1.26545320
53MP0010307_abnormal_tumor_latency1.25578114
54MP0004185_abnormal_adipocyte_glucose1.24578939
55MP0006054_spinal_hemorrhage1.23148627
56MP0002019_abnormal_tumor_incidence1.21928768
57MP0003283_abnormal_digestive_organ1.18056133
58MP0002938_white_spotting1.15746621
59MP0003303_peritoneal_inflammation1.14769518
60MP0000631_abnormal_neuroendocrine_gland1.14275855
61* MP0000703_abnormal_thymus_morphology1.12117900
62* MP0003763_abnormal_thymus_physiology1.11642441
63MP0000049_abnormal_middle_ear1.11414941
64MP0009250_abnormal_appendicular_skeleto1.07854196
65* MP0002398_abnormal_bone_marrow1.07354380
66MP0002653_abnormal_ependyma_morphology1.07286631
67MP0004133_heterotaxia1.07121840
68MP0002233_abnormal_nose_morphology1.06140642
69MP0009333_abnormal_splenocyte_physiolog1.05524644
70MP0002697_abnormal_eye_size1.03077872
71* MP0002116_abnormal_craniofacial_bone1.02673361
72MP0009697_abnormal_copulation1.02231125
73MP0005499_abnormal_olfactory_system1.02190519
74MP0002210_abnormal_sex_determination1.02133519
75MP0010368_abnormal_lymphatic_system1.00940716
76MP0000858_altered_metastatic_potential1.00690261
77MP0008789_abnormal_olfactory_epithelium0.99797429
78MP0005197_abnormal_uvea_morphology0.99355653
79MP0001348_abnormal_lacrimal_gland0.95985576
80MP0006292_abnormal_olfactory_placode0.94619724
81MP0005623_abnormal_meninges_morphology0.93580881
82* MP0002722_abnormal_immune_system0.91615235
83MP0002163_abnormal_gland_morphology0.90953150
84MP0001661_extended_life_span0.90602675
85MP0001663_abnormal_digestive_system0.88895796
86MP0002111_abnormal_tail_morphology0.88863982
87MP0002160_abnormal_reproductive_system0.87059514
88MP0000428_abnormal_craniofacial_morphol0.86720136
89MP0001286_abnormal_eye_development0.86661036
90MP0003942_abnormal_urinary_system0.86420508
91MP0001545_abnormal_hematopoietic_system0.86386289
92MP0005397_hematopoietic_system_phenotyp0.86386289
93MP0000358_abnormal_cell_content/0.85307750
94* MP0003115_abnormal_respiratory_system0.85122513
95MP0002089_abnormal_postnatal_growth/wei0.85098529
96MP0001145_abnormal_male_reproductive0.84601162
97MP0003122_maternal_imprinting0.84544517
98* MP0001119_abnormal_female_reproductive0.84328678
99MP0003705_abnormal_hypodermis_morpholog0.82563363
100MP0000955_abnormal_spinal_cord0.82520794
101* MP0000689_abnormal_spleen_morphology0.82239416
102* MP0002429_abnormal_blood_cell0.81707556
103MP0003385_abnormal_body_wall0.81156917
104MP0000778_abnormal_nervous_system0.80928380
105MP0002184_abnormal_innervation0.80710557
106MP0001915_intracranial_hemorrhage0.80560512
107* MP0003937_abnormal_limbs/digits/tail_de0.80001452
108MP0000516_abnormal_urinary_system0.79523859
109MP0005367_renal/urinary_system_phenotyp0.79523859
110MP0002081_perinatal_lethality0.79247855
111* MP0002109_abnormal_limb_morphology0.78450975
112MP0002006_tumorigenesis0.77286569
113MP0002751_abnormal_autonomic_nervous0.76524983
114MP0009672_abnormal_birth_weight0.76282471
115MP0000733_abnormal_muscle_development0.75573454
116MP0000678_abnormal_parathyroid_gland0.73690508
117MP0009278_abnormal_bone_marrow0.73621857
118MP0002161_abnormal_fertility/fecundity0.72804953
119MP0002282_abnormal_trachea_morphology0.72568077
120* MP0000716_abnormal_immune_system0.72378738
121MP0003943_abnormal_hepatobiliary_system0.72135867
122MP0003755_abnormal_palate_morphology0.71271870
123MP0003935_abnormal_craniofacial_develop0.71158496
124MP0005075_abnormal_melanosome_morpholog0.70117320
125MP0002925_abnormal_cardiovascular_devel0.70060393
126MP0002932_abnormal_joint_morphology0.69476832
127MP0005671_abnormal_response_to0.68863215
128MP0002095_abnormal_skin_pigmentation0.68300669
129MP0000653_abnormal_sex_gland0.67876924
130MP0003861_abnormal_nervous_system0.67595574
131* MP0000432_abnormal_head_morphology0.66321550
132MP0003448_altered_tumor_morphology0.65242250
133MP0003718_maternal_effect0.64257467
134MP0001929_abnormal_gametogenesis0.64131402
135MP0005389_reproductive_system_phenotype0.63992873
136MP0002405_respiratory_system_inflammati0.63724946
137MP0002092_abnormal_eye_morphology0.63645276
138MP0005384_cellular_phenotype0.63291706
139MP0001835_abnormal_antigen_presentation0.62580442
140MP0005394_taste/olfaction_phenotype0.62511693

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.14008484
2Abnormality of the anterior horn cell (HP:0006802)3.86235835
3Degeneration of anterior horn cells (HP:0002398)3.86235835
4Progressive muscle weakness (HP:0003323)3.83198257
5Ureteral stenosis (HP:0000071)3.81039285
6Abnormality of the renal collecting system (HP:0004742)3.50046258
7Hyperacusis (HP:0010780)3.34260714
8Ureteral obstruction (HP:0006000)3.33134577
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26599879
10Acute lymphatic leukemia (HP:0006721)3.25533179
11Chromsome breakage (HP:0040012)3.16030144
12Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.15595732
13Reticulocytopenia (HP:0001896)3.15451445
1411 pairs of ribs (HP:0000878)3.11791407
15Patellar aplasia (HP:0006443)3.06856638
16Short 5th finger (HP:0009237)3.05236155
17Colon cancer (HP:0003003)3.04087993
18Meckel diverticulum (HP:0002245)3.01721175
19Selective tooth agenesis (HP:0001592)3.00900510
20Sparse lateral eyebrow (HP:0005338)2.94718544
21Aplasia/Hypoplasia of the patella (HP:0006498)2.94601301
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92034784
23Abnormality of the ileum (HP:0001549)2.91190493
24Abnormality of chromosome stability (HP:0003220)2.85165230
25Insomnia (HP:0100785)2.81623396
26Anal stenosis (HP:0002025)2.79644368
27Long foot (HP:0001833)2.79356029
28Abnormality of cochlea (HP:0000375)2.79347326
29Short 4th metacarpal (HP:0010044)2.78301915
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.78301915
31Medulloblastoma (HP:0002885)2.73335820
32Abnormality of the fingertips (HP:0001211)2.71373518
33Lip pit (HP:0100267)2.70190198
34Abnormality of the preputium (HP:0100587)2.64651613
35Hypoplastic pelvis (HP:0008839)2.64439742
36Oral leukoplakia (HP:0002745)2.62716865
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.62672061
38Abnormal number of incisors (HP:0011064)2.61587653
39Ectopic kidney (HP:0000086)2.59309338
40Carpal bone hypoplasia (HP:0001498)2.58558014
41Aplastic anemia (HP:0001915)2.54747666
42Absent radius (HP:0003974)2.50790238
43Breast hypoplasia (HP:0003187)2.49951023
44Overriding aorta (HP:0002623)2.47324382
45Morphological abnormality of the inner ear (HP:0011390)2.44055746
46Absent thumb (HP:0009777)2.44047823
47Abnormal lung lobation (HP:0002101)2.43000237
48Transposition of the great arteries (HP:0001669)2.40779576
49Abnormal connection of the cardiac segments (HP:0011545)2.40779576
50Abnormal ventriculo-arterial connection (HP:0011563)2.40779576
51Elfin facies (HP:0004428)2.40115508
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.37208994
53Small intestinal stenosis (HP:0012848)2.37069492
54Duodenal stenosis (HP:0100867)2.37069492
55Optic nerve coloboma (HP:0000588)2.36328767
56Premature graying of hair (HP:0002216)2.36173596
57Aplasia involving forearm bones (HP:0009822)2.31015826
58Absent forearm bone (HP:0003953)2.31015826
59Abnormality of alanine metabolism (HP:0010916)2.29537145
60Hyperalaninemia (HP:0003348)2.29537145
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29537145
62Ureteral duplication (HP:0000073)2.27495642
63Spinal cord lesions (HP:0100561)2.26643371
64Syringomyelia (HP:0003396)2.26643371
65Nephroblastoma (Wilms tumor) (HP:0002667)2.25196000
66Trismus (HP:0000211)2.25107737
67Missing ribs (HP:0000921)2.25035157
68Embryonal renal neoplasm (HP:0011794)2.24255861
69Triphalangeal thumb (HP:0001199)2.23994219
70Self-mutilation (HP:0000742)2.21173911
71Myelodysplasia (HP:0002863)2.20467268
72Ependymoma (HP:0002888)2.17647687
73Autoimmune thrombocytopenia (HP:0001973)2.15507635
74Bone marrow hypocellularity (HP:0005528)2.15393788
75Duplication of thumb phalanx (HP:0009942)2.14300273
76Partial agenesis of the corpus callosum (HP:0001338)2.14050094
77Broad thumb (HP:0011304)2.10941760
78Fibular aplasia (HP:0002990)2.10698426
79Abnormal number of erythroid precursors (HP:0012131)2.10224972
80Preauricular pit (HP:0004467)2.09851767
81Periauricular skin pits (HP:0100277)2.09851767
82Agnosia (HP:0010524)2.09769618
83Abnormality of the phalanges of the hallux (HP:0010057)2.08659031
84Deviation of the thumb (HP:0009603)2.08527980
85Atresia of the external auditory canal (HP:0000413)2.07724282
86Neoplasm of the pancreas (HP:0002894)2.07541059
87Rough bone trabeculation (HP:0100670)2.04497658
88Abnormality of cells of the erythroid lineage (HP:0012130)2.03911297
89Proximal placement of thumb (HP:0009623)2.01369481
90Supernumerary spleens (HP:0009799)2.01241591
91Horseshoe kidney (HP:0000085)2.00294938
92Cortical dysplasia (HP:0002539)2.00178006
93Reduced subcutaneous adipose tissue (HP:0003758)2.00059618
94Tracheoesophageal fistula (HP:0002575)1.99552261
95Lymphoma (HP:0002665)1.99519779
96Cleft eyelid (HP:0000625)1.98955271
97Facial cleft (HP:0002006)1.98831425
98Abnormality of the duodenum (HP:0002246)1.97695001
99Increased nuchal translucency (HP:0010880)1.97321385
100Cellular immunodeficiency (HP:0005374)1.97003532
101Abnormality of fatty-acid metabolism (HP:0004359)1.96634937
102Short middle phalanx of the 5th finger (HP:0004220)1.95275959
103Type I transferrin isoform profile (HP:0003642)1.95192095
104Posterior embryotoxon (HP:0000627)1.89116821
105Abnormality of the carotid arteries (HP:0005344)1.88826592
106Renal duplication (HP:0000075)1.87941398
107Polymicrogyria (HP:0002126)1.85912573
108Amaurosis fugax (HP:0100576)1.85586483
109Sloping forehead (HP:0000340)1.85030220
110Volvulus (HP:0002580)1.82127416
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81295045
112Rectal fistula (HP:0100590)1.81096437
113Rectovaginal fistula (HP:0000143)1.81096437
114Abnormality of the calcaneus (HP:0008364)1.80233680
115Brushfield spots (HP:0001088)1.79513528
116Coarctation of aorta (HP:0001680)1.78717110
117Tetralogy of Fallot (HP:0001636)1.78505878
118Abnormally folded helix (HP:0008544)1.78434416
119Broad distal phalanx of finger (HP:0009836)1.78042354
120Rhabdomyosarcoma (HP:0002859)1.77251765
121Squamous cell carcinoma (HP:0002860)1.76478996
122Abdominal situs inversus (HP:0003363)1.76375634
123Abnormality of abdominal situs (HP:0011620)1.76375634
124Flat face (HP:0012368)1.74895806
125Overfolded helix (HP:0000396)1.74148035
126Preauricular skin tag (HP:0000384)1.74123412
127Severe muscular hypotonia (HP:0006829)1.74085818
128Prominent metopic ridge (HP:0005487)1.74045609
129Aplasia/Hypoplasia of the nipples (HP:0006709)1.74040929
130Renovascular hypertension (HP:0100817)1.73849142
131Slender long bone (HP:0003100)1.73289258
132Stenosis of the external auditory canal (HP:0000402)1.73181436
133High anterior hairline (HP:0009890)1.72157027
134Unilateral renal agenesis (HP:0000122)1.71906994
135Abnormality of the metopic suture (HP:0005556)1.71485245
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.71235347
137Clubbing of toes (HP:0100760)1.71010803
138Concave nail (HP:0001598)1.70855095
139IgM deficiency (HP:0002850)1.70784230
140Septate vagina (HP:0001153)1.70414595
141Aplasia involving bones of the upper limbs (HP:0009823)1.69591672
142Aplasia of the phalanges of the hand (HP:0009802)1.69591672
143Aplasia involving bones of the extremities (HP:0009825)1.69591672
144Broad phalanges of the hand (HP:0009768)1.68469810
145Trigonocephaly (HP:0000243)1.68355095
146Abnormality of the 4th metacarpal (HP:0010012)1.68353456
147Intestinal fistula (HP:0100819)1.68139887
148Long eyelashes (HP:0000527)1.68020006
149Broad palm (HP:0001169)1.67296873
150Long palpebral fissure (HP:0000637)1.66734486
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65973977
152Broad hallux (HP:0010055)1.65619558
153Thrombocytosis (HP:0001894)1.65588793
154Pallor (HP:0000980)1.65509068
155Short thumb (HP:0009778)1.64890098
156Basal cell carcinoma (HP:0002671)1.64709430
157Cerebral hypomyelination (HP:0006808)1.64657983
158Patellar dislocation (HP:0002999)1.64200687
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63845576
160Duplicated collecting system (HP:0000081)1.63832998
161Abnormality of the line of Schwalbe (HP:0008048)1.63577077
162Abnormality of reticulocytes (HP:0004312)1.63247858
163Pointed chin (HP:0000307)1.63000689
164Microretrognathia (HP:0000308)1.61578841
165Diastasis recti (HP:0001540)1.60890146
166Impulsivity (HP:0100710)1.60711340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.26719947
2BUB14.18288279
3WEE13.51326258
4EIF2AK13.43644937
5SRPK13.30845738
6EEF2K3.26132475
7MAP3K32.89811256
8WNK42.78354441
9MKNK12.51028879
10NEK22.49343276
11ACVR1B2.48200268
12SMG12.29211788
13TESK22.10827288
14BRSK22.10325832
15TAOK12.10264884
16VRK12.08225276
17PASK2.07671127
18NEK12.07516359
19MAP2K32.04549322
20VRK22.03263310
21TGFBR12.01630114
22EIF2AK31.96493354
23ATR1.94707848
24CDK121.85976847
25PLK31.85309239
26TTK1.84993958
27RPS6KA41.83772447
28TLK11.81478231
29PLK11.80165425
30STK391.73264563
31MKNK21.72570551
32CDK71.66844926
33TSSK61.64620137
34PLK41.63589107
35ZAK1.62659985
36AURKB1.54534308
37NME21.50014568
38BRSK11.48806077
39MAP3K101.47651675
40TESK11.41461773
41TRIB31.34958328
42BCKDK1.27026278
43* CHEK21.26699973
44SCYL21.25663985
45DYRK31.22316044
46CHEK11.22044152
47BRD41.21862306
48ICK1.21524454
49CDK81.20833164
50CLK11.15458615
51AURKA1.12846134
52ERBB31.12694461
53CDK41.12014489
54RPS6KB21.11703735
55EIF2AK21.10968126
56STK41.09038447
57TAF11.01658992
58MAPKAPK51.00321287
59STK100.97558554
60MAP3K80.95691393
61PBK0.94782525
62STK160.93078844
63MELK0.91346316
64CCNB10.91023468
65ATM0.88571131
66ABL20.87564494
67CSNK1G30.86278276
68SIK30.86133514
69ARAF0.85872174
70KDR0.83759293
71IRAK40.82616130
72* CDK20.81973941
73PIM10.81244671
74BMPR1B0.79961843
75PAK40.78968568
76DYRK1A0.78633823
77MAP3K90.77386720
78CDK60.75712911
79TXK0.75112231
80PNCK0.73627368
81LIMK10.72948840
82CDK90.70945281
83NTRK20.70740369
84NUAK10.70692177
85CSNK1A1L0.69406783
86MAPK110.68397692
87PIM20.68155438
88YES10.67868085
89CSNK1G10.66368060
90LATS20.65601303
91BCR0.63177678
92* CDK10.62525035
93CSNK2A10.62070827
94PAK10.60524780
95TAOK20.59565267
96CAMK1D0.59489903
97RPS6KA60.58618964
98IRAK30.57491274
99EPHA20.56042657
100MAP4K10.55692457
101CSNK2A20.55267134
102TYRO30.55238579
103FLT30.54541902
104CHUK0.54414578
105WNK10.54392992
106RPS6KL10.54189043
107RPS6KC10.54189043
108PINK10.53031370
109CDK11A0.52999006
110PRKCQ0.51763666
111BTK0.49990579
112RPS6KA50.48600550
113CAMK1G0.48024986
114CDK150.47929736
115STK30.47860965
116CSNK1G20.46637661
117STK38L0.45206903
118BRAF0.45190233
119MTOR0.44164168
120DYRK20.43383526
121CDK180.41933143
122FGFR10.41773359
123LRRK20.41596353
124PRKCI0.39177425
125MAP3K110.38937461
126CAMK40.38035107
127ALK0.38024931
128CDK190.37751985
129NEK90.36248170
130NLK0.35709787
131CDK140.34878517
132TEC0.34563458
133NTRK10.33564292
134MAP3K20.32406031
135KSR20.30872437
136AKT10.30553813
137PRKDC0.29200475
138CSNK1E0.28627960
139MAP3K140.28530008
140MAP3K10.28082442
141MAP3K50.27023299
142ZAP700.26875879
143KSR10.26171648
144AKT20.25716311
145STK240.24656879
146KIT0.24542837
147* MAPK140.24167309
148ILK0.21640457
149AKT30.20285775
150MAPKAPK20.19328872

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.75752480
2Mismatch repair_Homo sapiens_hsa034304.03374036
3Spliceosome_Homo sapiens_hsa030403.29907508
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11677892
5Homologous recombination_Homo sapiens_hsa034403.03754671
6Base excision repair_Homo sapiens_hsa034102.95711203
7Cell cycle_Homo sapiens_hsa041102.83070124
8RNA transport_Homo sapiens_hsa030132.78480994
9Proteasome_Homo sapiens_hsa030502.69944855
10Nucleotide excision repair_Homo sapiens_hsa034202.62160924
11Ribosome_Homo sapiens_hsa030102.58415927
12Sulfur relay system_Homo sapiens_hsa041222.47057548
13RNA polymerase_Homo sapiens_hsa030202.35821837
14Fanconi anemia pathway_Homo sapiens_hsa034602.25984442
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15570991
16One carbon pool by folate_Homo sapiens_hsa006702.14102116
17Pyrimidine metabolism_Homo sapiens_hsa002402.05276247
18RNA degradation_Homo sapiens_hsa030182.03440598
19Non-homologous end-joining_Homo sapiens_hsa034501.96943004
20Lysine degradation_Homo sapiens_hsa003101.96716462
21Biosynthesis of amino acids_Homo sapiens_hsa012301.96561681
22mRNA surveillance pathway_Homo sapiens_hsa030151.91837100
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77809927
24Basal transcription factors_Homo sapiens_hsa030221.70433849
25p53 signaling pathway_Homo sapiens_hsa041151.64357265
26Arginine biosynthesis_Homo sapiens_hsa002201.57511969
27Systemic lupus erythematosus_Homo sapiens_hsa053221.37696305
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35009855
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.29615226
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28546348
31Herpes simplex infection_Homo sapiens_hsa051681.22608212
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.22338762
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22126397
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20371231
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16021144
36Antigen processing and presentation_Homo sapiens_hsa046121.11878557
37Viral carcinogenesis_Homo sapiens_hsa052031.11780583
38Carbon metabolism_Homo sapiens_hsa012001.10550656
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07655203
40HTLV-I infection_Homo sapiens_hsa051661.07264584
41Purine metabolism_Homo sapiens_hsa002301.04279076
42Legionellosis_Homo sapiens_hsa051341.04039645
43MicroRNAs in cancer_Homo sapiens_hsa052061.02765913
44Oocyte meiosis_Homo sapiens_hsa041141.00334652
45Fatty acid elongation_Homo sapiens_hsa000620.92635730
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88136940
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88035978
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87512861
49Thyroid cancer_Homo sapiens_hsa052160.87178860
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85234912
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84784711
52Allograft rejection_Homo sapiens_hsa053300.83932009
53Graft-versus-host disease_Homo sapiens_hsa053320.82570345
54Hippo signaling pathway_Homo sapiens_hsa043900.79309037
55Measles_Homo sapiens_hsa051620.78901121
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78432173
57Shigellosis_Homo sapiens_hsa051310.77662065
58Primary immunodeficiency_Homo sapiens_hsa053400.77397397
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76504648
60Basal cell carcinoma_Homo sapiens_hsa052170.75974402
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.75908460
62TGF-beta signaling pathway_Homo sapiens_hsa043500.74375932
63Viral myocarditis_Homo sapiens_hsa054160.74213596
64Protein export_Homo sapiens_hsa030600.73649013
65N-Glycan biosynthesis_Homo sapiens_hsa005100.72931709
66Colorectal cancer_Homo sapiens_hsa052100.71334316
67Small cell lung cancer_Homo sapiens_hsa052220.70440264
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68541757
69Notch signaling pathway_Homo sapiens_hsa043300.68289639
70Folate biosynthesis_Homo sapiens_hsa007900.68121651
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67491512
72Hepatitis B_Homo sapiens_hsa051610.67441125
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66949071
74Alcoholism_Homo sapiens_hsa050340.66729806
75Arginine and proline metabolism_Homo sapiens_hsa003300.66422259
76Pyruvate metabolism_Homo sapiens_hsa006200.66075327
77Apoptosis_Homo sapiens_hsa042100.62244540
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61792799
79Type I diabetes mellitus_Homo sapiens_hsa049400.61046359
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60440905
81Huntingtons disease_Homo sapiens_hsa050160.59425984
82Adherens junction_Homo sapiens_hsa045200.58672265
83Chronic myeloid leukemia_Homo sapiens_hsa052200.56459438
84* AMPK signaling pathway_Homo sapiens_hsa041520.54240843
85Influenza A_Homo sapiens_hsa051640.53842962
86Leishmaniasis_Homo sapiens_hsa051400.53795711
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52730405
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.50083197
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49682454
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49485404
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48184242
92Asthma_Homo sapiens_hsa053100.47910149
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47324633
94Autoimmune thyroid disease_Homo sapiens_hsa053200.46498417
95Taste transduction_Homo sapiens_hsa047420.46340397
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46276148
97Pathways in cancer_Homo sapiens_hsa052000.45812824
98Wnt signaling pathway_Homo sapiens_hsa043100.44405844
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42270177
100Vitamin B6 metabolism_Homo sapiens_hsa007500.42069025
101Hedgehog signaling pathway_Homo sapiens_hsa043400.41400528
102Bladder cancer_Homo sapiens_hsa052190.40051838
103Selenocompound metabolism_Homo sapiens_hsa004500.40047018
104Hematopoietic cell lineage_Homo sapiens_hsa046400.39926171
105Prostate cancer_Homo sapiens_hsa052150.39275722
106T cell receptor signaling pathway_Homo sapiens_hsa046600.38685177
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38560352
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37349275
109HIF-1 signaling pathway_Homo sapiens_hsa040660.36406610
110Proteoglycans in cancer_Homo sapiens_hsa052050.35238253
111Parkinsons disease_Homo sapiens_hsa050120.34993536
112Acute myeloid leukemia_Homo sapiens_hsa052210.34384051
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34322452
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34182683
115Salmonella infection_Homo sapiens_hsa051320.34149543
116Pentose phosphate pathway_Homo sapiens_hsa000300.33737333
117Phototransduction_Homo sapiens_hsa047440.33375096
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.31168455
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30724560
120Metabolic pathways_Homo sapiens_hsa011000.30536657
121TNF signaling pathway_Homo sapiens_hsa046680.30396175
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.29626022
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29244273
124Steroid biosynthesis_Homo sapiens_hsa001000.28310372
125Pancreatic cancer_Homo sapiens_hsa052120.26861473
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26738067
127Melanoma_Homo sapiens_hsa052180.26717669
128Glioma_Homo sapiens_hsa052140.26589737
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.26362306
130Fatty acid metabolism_Homo sapiens_hsa012120.26156955
131Prion diseases_Homo sapiens_hsa050200.26004966
132Endometrial cancer_Homo sapiens_hsa052130.25941424
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25563647
134Non-small cell lung cancer_Homo sapiens_hsa052230.25076383
135B cell receptor signaling pathway_Homo sapiens_hsa046620.24794342
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23951438
137Malaria_Homo sapiens_hsa051440.23676934
138Melanogenesis_Homo sapiens_hsa049160.23515790
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.23441845
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23185920
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22395126
142Propanoate metabolism_Homo sapiens_hsa006400.22219028
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22023980
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.21367071
145Dopaminergic synapse_Homo sapiens_hsa047280.21017900
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20456493
147beta-Alanine metabolism_Homo sapiens_hsa004100.18527427

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »