ELAVL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.35040144
2axon ensheathment in central nervous system (GO:0032291)6.35040144
3neuron cell-cell adhesion (GO:0007158)5.32307075
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.16773276
5synaptic vesicle maturation (GO:0016188)4.54526930
6dendritic spine morphogenesis (GO:0060997)4.45842121
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44386134
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.43552811
9vocalization behavior (GO:0071625)4.42018352
10cellular potassium ion homeostasis (GO:0030007)4.37453007
11locomotory exploration behavior (GO:0035641)4.37409985
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34426267
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29360498
14neuron recognition (GO:0008038)4.26699733
15presynaptic membrane organization (GO:0097090)4.16113711
16protein localization to synapse (GO:0035418)4.14808936
17layer formation in cerebral cortex (GO:0021819)4.13214628
18positive regulation of synapse maturation (GO:0090129)4.07345957
19synaptic vesicle exocytosis (GO:0016079)4.05453122
20nucleobase catabolic process (GO:0046113)4.04802957
21presynaptic membrane assembly (GO:0097105)4.04385713
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.03923628
23establishment of mitochondrion localization (GO:0051654)3.94060403
24neuronal action potential propagation (GO:0019227)3.91223031
25transmission of nerve impulse (GO:0019226)3.89386567
26regulation of synaptic vesicle exocytosis (GO:2000300)3.88161481
27axonal fasciculation (GO:0007413)3.87024030
28long-chain fatty acid biosynthetic process (GO:0042759)3.85901095
29behavioral response to nicotine (GO:0035095)3.83518252
30myelination (GO:0042552)3.82925432
31axon ensheathment (GO:0008366)3.79680461
32ensheathment of neurons (GO:0007272)3.79680461
33glutamate secretion (GO:0014047)3.74769512
34dendrite morphogenesis (GO:0048813)3.74201031
35regulation of glutamate receptor signaling pathway (GO:1900449)3.69269370
36negative regulation of neurotransmitter transport (GO:0051589)3.64409391
37glutamate receptor signaling pathway (GO:0007215)3.63283717
38cell migration in hindbrain (GO:0021535)3.60959031
39gamma-aminobutyric acid transport (GO:0015812)3.57519157
40synaptic transmission, glutamatergic (GO:0035249)3.56527791
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55613014
42adult walking behavior (GO:0007628)3.54361827
43neuronal ion channel clustering (GO:0045161)3.53879464
44cell differentiation in hindbrain (GO:0021533)3.53852732
45exploration behavior (GO:0035640)3.52935328
46regulation of neuronal synaptic plasticity (GO:0048168)3.49434718
47L-amino acid import (GO:0043092)3.49339883
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48064559
49neuromuscular synaptic transmission (GO:0007274)3.46268127
50cerebellar granule cell differentiation (GO:0021707)3.44672637
51sodium ion export (GO:0071436)3.44397700
52neurofilament cytoskeleton organization (GO:0060052)3.39268183
53membrane depolarization during action potential (GO:0086010)3.37748556
54fatty acid elongation (GO:0030497)3.37620043
55cerebral cortex radially oriented cell migration (GO:0021799)3.37351242
56neuron-neuron synaptic transmission (GO:0007270)3.37133373
57negative regulation of neurotransmitter secretion (GO:0046929)3.34814758
58postsynaptic membrane organization (GO:0001941)3.34614011
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.34425886
60pyrimidine nucleobase catabolic process (GO:0006208)3.34389547
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31277568
62regulation of synapse maturation (GO:0090128)3.31229106
63regulation of synaptic vesicle transport (GO:1902803)3.28927981
64regulation of neurotransmitter levels (GO:0001505)3.28741585
65negative regulation of axonogenesis (GO:0050771)3.27851364
66central nervous system projection neuron axonogenesis (GO:0021952)3.25555272
67positive regulation of membrane potential (GO:0045838)3.21675150
68membrane depolarization (GO:0051899)3.18725179
69regulation of synapse structural plasticity (GO:0051823)3.18271339
70neurotransmitter secretion (GO:0007269)3.17021676
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16065002
72adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14596547
73potassium ion homeostasis (GO:0055075)3.14206232
74regulation of dendritic spine morphogenesis (GO:0061001)3.13427073
75negative regulation of axon extension (GO:0030517)3.13313250
76auditory behavior (GO:0031223)3.12775217
77regulation of neurotransmitter transport (GO:0051588)3.11224726
78synaptic vesicle endocytosis (GO:0048488)3.10752595
79regulation of vesicle fusion (GO:0031338)3.10049338
80glycine transport (GO:0015816)3.09911855
81long-term memory (GO:0007616)3.08149903
82regulation of collateral sprouting (GO:0048670)3.07779329
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07709373
84mating behavior (GO:0007617)3.07179296
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06829876
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06420390
87axon extension (GO:0048675)3.04456783
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03314367
89regulation of voltage-gated calcium channel activity (GO:1901385)3.02591334
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01613836
91positive regulation of synapse assembly (GO:0051965)3.00453460
92negative regulation of microtubule polymerization (GO:0031115)2.99235356
93neurotransmitter-gated ion channel clustering (GO:0072578)2.98539075
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.98219326
95synapse assembly (GO:0007416)2.95401776
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93535062
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92269519
98mitochondrion transport along microtubule (GO:0047497)2.92269519
99membrane hyperpolarization (GO:0060081)2.91644855
100startle response (GO:0001964)2.91129248
101regulation of postsynaptic membrane potential (GO:0060078)2.90834720
102potassium ion import (GO:0010107)2.89511746
103substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.88943611
104substrate-independent telencephalic tangential migration (GO:0021826)2.88943611
105neurotransmitter transport (GO:0006836)2.88000106
106dendritic spine organization (GO:0097061)2.87806385
107negative regulation of protein localization to cell surface (GO:2000009)2.86872797
108positive regulation of dendritic spine development (GO:0060999)2.84765782
109nerve growth factor signaling pathway (GO:0038180)2.84315991
110neuron remodeling (GO:0016322)2.84215895
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.83714111
112neuromuscular process controlling balance (GO:0050885)2.82726412
113regulation of dendritic spine development (GO:0060998)2.82674437
114regulation of neurotransmitter secretion (GO:0046928)2.82195898
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80818466
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80648180
117dendrite development (GO:0016358)2.80034816
118negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.78575909
119mechanosensory behavior (GO:0007638)2.78351657
120response to auditory stimulus (GO:0010996)2.77908440
121oligodendrocyte differentiation (GO:0048709)2.77011976
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76836940
123central nervous system neuron axonogenesis (GO:0021955)2.76687057
124synapse organization (GO:0050808)2.76537593
125regulation of synaptic plasticity (GO:0048167)2.74934575
126amino acid import (GO:0043090)2.74223043
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.73741749
128regulation of respiratory system process (GO:0044065)2.73279539
129cerebellar Purkinje cell differentiation (GO:0021702)2.72682890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50987469
2GBX2_23144817_ChIP-Seq_PC3_Human3.44231763
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07737218
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01032125
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93148404
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.72376361
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71084808
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71084808
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56696143
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47354550
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46615896
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43539110
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41474934
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.39318016
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38973582
16REST_21632747_ChIP-Seq_MESCs_Mouse2.37618271
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36660517
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32953925
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26039133
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.22890261
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18013626
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.16025088
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.04336483
24AR_21572438_ChIP-Seq_LNCaP_Human1.98949851
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90442026
26TAF15_26573619_Chip-Seq_HEK293_Human1.87773125
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84584463
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78840580
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75675995
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.73979914
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71184681
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69732692
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65977463
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65302755
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63020674
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58954811
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55959306
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55177147
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54887334
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52095929
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47400795
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46679051
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46167913
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.39527161
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38644168
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.36557751
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.36010346
48* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35660085
49SMAD4_21799915_ChIP-Seq_A2780_Human1.35145892
50RNF2_27304074_Chip-Seq_NSC_Mouse1.35094395
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32618712
52P300_19829295_ChIP-Seq_ESCs_Human1.31861088
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.28642118
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.28397211
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27249241
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25155171
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23799696
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21897179
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20156979
60* CTCF_27219007_Chip-Seq_Bcells_Human1.19788850
61ER_23166858_ChIP-Seq_MCF-7_Human1.18985242
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18366537
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16141658
64STAT3_23295773_ChIP-Seq_U87_Human1.15581652
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.14702566
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.14343055
67ZNF274_21170338_ChIP-Seq_K562_Hela1.13912909
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13869950
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13388901
70VDR_22108803_ChIP-Seq_LS180_Human1.12174129
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12143500
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11989632
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11769909
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11551288
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11156271
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10916965
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10149649
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10001224
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05449190
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03533817
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03524356
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03524356
83IGF1R_20145208_ChIP-Seq_DFB_Human1.03462858
84TCF4_23295773_ChIP-Seq_U87_Human1.02697750
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.01903301
86AHR_22903824_ChIP-Seq_MCF-7_Human0.99747837
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99584960
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.98843506
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98783518
90FUS_26573619_Chip-Seq_HEK293_Human0.98321081
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97950229
92* AR_19668381_ChIP-Seq_PC3_Human0.97508829
93AR_25329375_ChIP-Seq_VCAP_Human0.97343843
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97285112
95* RUNX2_22187159_ChIP-Seq_PCA_Human0.96457456
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96448853
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95484365
98* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95195657
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94904489
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93395115
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91823878
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91332925
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90847432
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90310136
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.88375098
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87980716
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.87502736
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.86660908
109* KDM2B_26808549_Chip-Seq_K562_Human0.86396611
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85922593
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85190602
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.84950735
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84861698
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84247499
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79989507
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77652994
117OCT4_19829295_ChIP-Seq_ESCs_Human0.76023267
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75175593
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.72278799
120STAT3_18555785_ChIP-Seq_MESCs_Mouse0.71493316
121SOX9_26525672_Chip-Seq_HEART_Mouse0.70300847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.97493407
2MP0003880_abnormal_central_pattern4.88694824
3MP0004270_analgesia3.89315861
4MP0003635_abnormal_synaptic_transmissio3.46995805
5MP0005423_abnormal_somatic_nervous3.28306279
6MP0009745_abnormal_behavioral_response2.91111902
7MP0002064_seizures2.88969316
8MP0002063_abnormal_learning/memory/cond2.79947536
9MP0000778_abnormal_nervous_system2.78372392
10MP0001486_abnormal_startle_reflex2.76691867
11MP0002272_abnormal_nervous_system2.69072946
12MP0009046_muscle_twitch2.67518098
13MP0002734_abnormal_mechanical_nocicepti2.62872636
14MP0000920_abnormal_myelination2.56258110
15MP0002572_abnormal_emotion/affect_behav2.46451611
16MP0001968_abnormal_touch/_nociception2.30801729
17MP0004885_abnormal_endolymph2.25756739
18MP0003329_amyloid_beta_deposits2.11816206
19MP0003123_paternal_imprinting2.08288203
20MP0001529_abnormal_vocalization2.03566666
21MP0001440_abnormal_grooming_behavior2.00018435
22MP0004742_abnormal_vestibular_system1.99054240
23MP0002733_abnormal_thermal_nociception1.98806745
24MP0002184_abnormal_innervation1.96535889
25MP0002822_catalepsy1.96292934
26MP0002735_abnormal_chemical_nociception1.94480348
27MP0001970_abnormal_pain_threshold1.93328256
28MP0002067_abnormal_sensory_capabilities1.87404922
29MP0006276_abnormal_autonomic_nervous1.86807596
30MP0000955_abnormal_spinal_cord1.85652005
31MP0001905_abnormal_dopamine_level1.84628290
32MP0004142_abnormal_muscle_tone1.81632399
33MP0003121_genomic_imprinting1.77513243
34MP0008569_lethality_at_weaning1.76051375
35MP0002736_abnormal_nociception_after1.73958111
36MP0002882_abnormal_neuron_morphology1.71677121
37MP0004924_abnormal_behavior1.70607871
38MP0005386_behavior/neurological_phenoty1.70607871
39MP0002557_abnormal_social/conspecific_i1.68889342
40MP0004811_abnormal_neuron_physiology1.60059253
41MP0001984_abnormal_olfaction1.59444350
42MP0002066_abnormal_motor_capabilities/c1.53409730
43MP0003690_abnormal_glial_cell1.53169633
44MP0001501_abnormal_sleep_pattern1.52866410
45MP0003634_abnormal_glial_cell1.51150681
46MP0001485_abnormal_pinna_reflex1.50017072
47MP0005645_abnormal_hypothalamus_physiol1.45472491
48MP0005409_darkened_coat_color1.43607681
49MP0002229_neurodegeneration1.39546979
50MP0004858_abnormal_nervous_system1.37568056
51MP0002152_abnormal_brain_morphology1.32372123
52MP0003632_abnormal_nervous_system1.27766775
53MP0003631_nervous_system_phenotype1.25280947
54MP0002752_abnormal_somatic_nervous1.24410584
55MP0005171_absent_coat_pigmentation1.24342087
56MP0005646_abnormal_pituitary_gland1.22887552
57MP0003633_abnormal_nervous_system1.21906442
58MP0003787_abnormal_imprinting1.20579929
59MP0005551_abnormal_eye_electrophysiolog1.19688446
60MP0001963_abnormal_hearing_physiology1.13798869
61MP0001502_abnormal_circadian_rhythm1.12490582
62MP0001188_hyperpigmentation1.12358537
63MP0009780_abnormal_chondrocyte_physiolo1.09660372
64MP0005499_abnormal_olfactory_system1.09012470
65MP0005394_taste/olfaction_phenotype1.09012470
66MP0009379_abnormal_foot_pigmentation1.07077694
67MP0000631_abnormal_neuroendocrine_gland1.01563002
68MP0008877_abnormal_DNA_methylation0.99692386
69MP0000569_abnormal_digit_pigmentation0.98317084
70MP0003283_abnormal_digestive_organ0.95097577
71MP0004133_heterotaxia0.94570985
72MP0003136_yellow_coat_color0.94405714
73MP0003861_abnormal_nervous_system0.94380173
74MP0004145_abnormal_muscle_electrophysio0.93566376
75MP0001177_atelectasis0.90400781
76MP0002102_abnormal_ear_morphology0.89616368
77MP0003938_abnormal_ear_development0.87370211
78MP0000026_abnormal_inner_ear0.86835761
79MP0000604_amyloidosis0.86205135
80MP0001299_abnormal_eye_distance/0.85674936
81MP0003879_abnormal_hair_cell0.85235803
82MP0002069_abnormal_eating/drinking_beha0.84698573
83MP0005410_abnormal_fertilization0.80156133
84MP0008789_abnormal_olfactory_epithelium0.79976274
85MP0001986_abnormal_taste_sensitivity0.77482366
86MP0003890_abnormal_embryonic-extraembry0.77378211
87MP0010386_abnormal_urinary_bladder0.77107336
88MP0003137_abnormal_impulse_conducting0.77022586
89MP0004130_abnormal_muscle_cell0.75577935
90MP0006072_abnormal_retinal_apoptosis0.75241712
91MP0003122_maternal_imprinting0.75102984
92MP0000462_abnormal_digestive_system0.73444683
93MP0004085_abnormal_heartbeat0.71848961
94MP0005195_abnormal_posterior_eye0.71116472
95MP0002909_abnormal_adrenal_gland0.71027399
96MP0005623_abnormal_meninges_morphology0.70452725
97MP0000566_synostosis0.68046154
98MP0000751_myopathy0.67589394
99MP0002751_abnormal_autonomic_nervous0.67191429
100MP0004043_abnormal_pH_regulation0.67106130
101MP0002081_perinatal_lethality0.66661863
102MP0000534_abnormal_ureter_morphology0.65441810
103MP0003119_abnormal_digestive_system0.65113642
104MP0002653_abnormal_ependyma_morphology0.64862375
105MP0001348_abnormal_lacrimal_gland0.64660513
106MP0008874_decreased_physiological_sensi0.64398794
107MP0004134_abnormal_chest_morphology0.64357915
108MP0003942_abnormal_urinary_system0.64276614
109MP0001943_abnormal_respiration0.64018807
110MP0008872_abnormal_physiological_respon0.61578336
111MP0002638_abnormal_pupillary_reflex0.61312805
112MP0005187_abnormal_penis_morphology0.61079975
113MP0005253_abnormal_eye_physiology0.60464666
114MP0010769_abnormal_survival0.59563103
115MP0010770_preweaning_lethality0.59289441
116MP0002082_postnatal_lethality0.59289441
117MP0006292_abnormal_olfactory_placode0.58190121
118MP0010768_mortality/aging0.55901750

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.69574686
2Focal motor seizures (HP:0011153)4.95395127
3Neurofibrillary tangles (HP:0002185)4.71930467
4Abnormality of the corticospinal tract (HP:0002492)4.57958658
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.49378959
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.49378959
7Supranuclear gaze palsy (HP:0000605)4.39125944
8Focal seizures (HP:0007359)4.10284461
9Ankle clonus (HP:0011448)3.87692972
10Cerebral inclusion bodies (HP:0100314)3.78902187
11Epileptic encephalopathy (HP:0200134)3.68665903
12Spastic gait (HP:0002064)3.55244467
13Action tremor (HP:0002345)3.40122392
14Limb dystonia (HP:0002451)3.37735262
15Progressive cerebellar ataxia (HP:0002073)3.37320268
16Peripheral hypomyelination (HP:0007182)3.36510520
17Atonic seizures (HP:0010819)3.34776753
18Termporal pattern (HP:0011008)3.33830055
19Insidious onset (HP:0003587)3.33830055
20Broad-based gait (HP:0002136)3.30193033
21Dysmetria (HP:0001310)3.27709577
22Visual hallucinations (HP:0002367)3.21466341
23Intention tremor (HP:0002080)2.97933362
24Mutism (HP:0002300)2.88742837
25Sleep apnea (HP:0010535)2.86149419
26Scanning speech (HP:0002168)2.81226064
27Sensory axonal neuropathy (HP:0003390)2.78696631
28Akinesia (HP:0002304)2.74661585
29Megalencephaly (HP:0001355)2.69757354
30Hyperventilation (HP:0002883)2.67428455
31Failure to thrive in infancy (HP:0001531)2.65292253
32Febrile seizures (HP:0002373)2.62693323
33Urinary bladder sphincter dysfunction (HP:0002839)2.60732475
34Urinary urgency (HP:0000012)2.60405678
35Hemiplegia (HP:0002301)2.59893366
36Status epilepticus (HP:0002133)2.57702406
37Onion bulb formation (HP:0003383)2.57682055
38Cerebral hypomyelination (HP:0006808)2.55198078
39Drooling (HP:0002307)2.54648724
40Excessive salivation (HP:0003781)2.54648724
41Pheochromocytoma (HP:0002666)2.52723744
42Dialeptic seizures (HP:0011146)2.51415582
43Lower limb muscle weakness (HP:0007340)2.50506875
44Retinal dysplasia (HP:0007973)2.50391867
45Absence seizures (HP:0002121)2.50204711
46Generalized tonic-clonic seizures (HP:0002069)2.49633382
47Progressive inability to walk (HP:0002505)2.48281658
48Gaze-evoked nystagmus (HP:0000640)2.47404681
49Hemiparesis (HP:0001269)2.43956035
50Poor eye contact (HP:0000817)2.39264926
51Alacrima (HP:0000522)2.38458348
52Truncal ataxia (HP:0002078)2.37037129
53Dysdiadochokinesis (HP:0002075)2.36214939
54Abnormal eating behavior (HP:0100738)2.36065053
55Impaired vibration sensation in the lower limbs (HP:0002166)2.34157657
56Anxiety (HP:0000739)2.30308116
57Morphological abnormality of the pyramidal tract (HP:0002062)2.29904288
58Abnormality of the labia minora (HP:0012880)2.25203794
59Amblyopia (HP:0000646)2.24723004
60Obstructive sleep apnea (HP:0002870)2.22118648
61Amyotrophic lateral sclerosis (HP:0007354)2.21830722
62Spastic tetraplegia (HP:0002510)2.18808539
63Parakeratosis (HP:0001036)2.16054841
64Abnormality of the lower motor neuron (HP:0002366)2.15858202
65Thickened helices (HP:0000391)2.15060923
66Torticollis (HP:0000473)2.13513714
67Absent speech (HP:0001344)2.13463490
68Fetal akinesia sequence (HP:0001989)2.13108864
69Impaired social interactions (HP:0000735)2.11611589
70Abnormal social behavior (HP:0012433)2.11611589
71Depression (HP:0000716)2.11092874
72Neuroendocrine neoplasm (HP:0100634)2.10653498
73Clonus (HP:0002169)2.10639738
74Diplopia (HP:0000651)2.07735775
75Abnormality of binocular vision (HP:0011514)2.07735775
76Polyphagia (HP:0002591)2.04489921
77Hepatoblastoma (HP:0002884)2.04406543
78Postural instability (HP:0002172)2.02851746
79Impaired smooth pursuit (HP:0007772)2.02111223
80Specific learning disability (HP:0001328)2.01840814
81Bowel incontinence (HP:0002607)1.98485778
82Generalized myoclonic seizures (HP:0002123)1.98259849
83Annular pancreas (HP:0001734)1.97597644
84Hypoplasia of the corpus callosum (HP:0002079)1.97304870
85Incomplete penetrance (HP:0003829)1.96932066
86Focal dystonia (HP:0004373)1.96044593
87Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95870006
88Hypoplasia of the brainstem (HP:0002365)1.95870006
89EEG with generalized epileptiform discharges (HP:0011198)1.95229202
90Epileptiform EEG discharges (HP:0011182)1.94432027
91Abnormal auditory evoked potentials (HP:0006958)1.94024372
92Decreased lacrimation (HP:0000633)1.92688701
93Hypsarrhythmia (HP:0002521)1.92438199
94Gait imbalance (HP:0002141)1.92344795
95Blue irides (HP:0000635)1.91969087
96Neuronal loss in central nervous system (HP:0002529)1.91022145
97Poor suck (HP:0002033)1.90367521
98Aplasia of the phalanges of the hand (HP:0009802)1.89449666
99Aplasia involving bones of the extremities (HP:0009825)1.89449666
100Aplasia involving bones of the upper limbs (HP:0009823)1.89449666
101Genetic anticipation (HP:0003743)1.89118749
102Insomnia (HP:0100785)1.88998797
103Stereotypic behavior (HP:0000733)1.88292071
104Pachygyria (HP:0001302)1.86892714
105Bradykinesia (HP:0002067)1.85476304
106Absent septum pellucidum (HP:0001331)1.84444805
107Abnormality of salivation (HP:0100755)1.83640580
108Abnormal large intestine physiology (HP:0012700)1.81423903
109Papilledema (HP:0001085)1.80985569
110Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80898865
111Lissencephaly (HP:0001339)1.80457931
112Agitation (HP:0000713)1.80030134
113Anomalous pulmonary venous return (HP:0010772)1.78528018
114Partial agenesis of the corpus callosum (HP:0001338)1.77781244
115Slow saccadic eye movements (HP:0000514)1.77425428
116Spastic tetraparesis (HP:0001285)1.76328845
117Craniofacial dystonia (HP:0012179)1.75950636
118CNS hypomyelination (HP:0003429)1.73731000
119Abnormality of ocular smooth pursuit (HP:0000617)1.72527708
120Restlessness (HP:0000711)1.69884592
121Shawl scrotum (HP:0000049)1.69119262
122Inappropriate behavior (HP:0000719)1.68429339
123Hypoventilation (HP:0002791)1.67996516
124Morphological abnormality of the middle ear (HP:0008609)1.66993604
125Impaired vibratory sensation (HP:0002495)1.66229117
126Nephronophthisis (HP:0000090)1.65455511
127Abnormal hair whorl (HP:0010721)1.61134914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.72917948
2STK393.08634093
3EPHA42.68588676
4NTRK32.61293912
5CASK2.53012771
6OXSR12.49266293
7MAP3K92.39293210
8TNIK2.26276966
9MAP3K42.20405328
10NTRK22.15162075
11PAK62.12574499
12PNCK2.02549081
13MAPK132.01050134
14PKN11.96431092
15UHMK11.95995896
16MINK11.95006249
17PRPF4B1.94425906
18MAP2K71.89338579
19NTRK11.75176899
20CDK191.71458701
21LIMK11.63321316
22DYRK21.63295821
23TYRO31.58567684
24PHKG21.56983072
25PHKG11.56983072
26BCR1.52658794
27CDK51.47995749
28PINK11.47131975
29DAPK21.45616834
30CSNK1G21.43642683
31CSNK1G31.38006978
32CAMK2B1.25492874
33CSNK1A1L1.24260067
34SGK4941.23975389
35SGK2231.23975389
36EPHB11.22466855
37MAPKAPK51.20404021
38FGFR21.16390421
39MARK21.11218046
40KSR21.09731724
41WNK41.09332138
42WNK11.07680150
43ICK1.07150458
44SGK21.06781386
45CDK141.05288748
46MAP2K41.04470050
47CDK151.01858101
48CDK181.00304627
49PLK21.00185399
50ROCK21.00046605
51EPHB20.98936032
52CAMK2A0.98699081
53KSR10.98329195
54CSNK1G10.97460125
55SIK20.96781523
56ARAF0.94944621
57PAK30.94912872
58FGR0.94106407
59GRK50.92501983
60PRKD30.92103783
61CDK11A0.90862388
62NEK60.88434238
63FES0.87882675
64PRKCG0.87343442
65STK110.85701901
66CAMK2D0.82359607
67CAMKK10.81146547
68DYRK1A0.80831473
69SGK30.75345451
70CAMK1D0.72309675
71CAMK2G0.70654172
72RPS6KA20.68303228
73PRKCE0.65929037
74RIPK10.63804925
75MAP3K20.63094131
76ERBB20.61328309
77CAMK40.60545629
78FYN0.58861509
79MAPK120.57313080
80TESK20.56082354
81CAMK1G0.56031978
82IRAK20.54177561
83PRKCZ0.53529092
84RET0.52305683
85LATS20.51828105
86PRKCH0.51606384
87BMPR1B0.51317716
88MAP3K110.51190474
89PDPK10.51000677
90DYRK1B0.47630482
91PRKG10.46672018
92SGK10.45815125
93BRSK10.44879960
94CAMK10.44489553
95ALK0.42507379
96WNK30.42398662
97MUSK0.42313342
98MAPK80.41891163
99PRKACA0.41071929
100MAPK150.40713374
101ROCK10.38675833
102MAPK100.38559797
103INSRR0.38281188
104CSNK1D0.38267304
105PRKAA10.38107774
106BMPR20.38059379
107CAMKK20.37986389
108PRKD10.37919560
109MET0.37823657
110MAP3K60.37694899
111MAP3K120.37010428
112DAPK30.36340416
113STK380.35582057
114RPS6KA30.35360911
115TAOK10.34234211
116CSNK1E0.34072710
117ERBB30.34050175
118GSK3B0.33890722
119PRKCQ0.32868388
120CSNK1A10.32781547
121DAPK10.32641447
122ADRBK20.31878984
123BRAF0.30794083
124PRKCA0.29039795
125DMPK0.27275384

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.15461408
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.72316406
3Glutamatergic synapse_Homo sapiens_hsa047242.69871881
4Synaptic vesicle cycle_Homo sapiens_hsa047212.66091081
5GABAergic synapse_Homo sapiens_hsa047272.63745880
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54423177
7Morphine addiction_Homo sapiens_hsa050322.36932381
8Circadian entrainment_Homo sapiens_hsa047132.36390019
9Olfactory transduction_Homo sapiens_hsa047402.34406469
10Axon guidance_Homo sapiens_hsa043602.21622712
11Dopaminergic synapse_Homo sapiens_hsa047282.07763501
12Serotonergic synapse_Homo sapiens_hsa047262.01557033
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00796920
14Long-term potentiation_Homo sapiens_hsa047201.96453197
15Cholinergic synapse_Homo sapiens_hsa047251.87934355
16Long-term depression_Homo sapiens_hsa047301.87844322
17Amphetamine addiction_Homo sapiens_hsa050311.85980900
18Salivary secretion_Homo sapiens_hsa049701.74801768
19Steroid biosynthesis_Homo sapiens_hsa001001.70160790
20Cocaine addiction_Homo sapiens_hsa050301.67370405
21Taste transduction_Homo sapiens_hsa047421.64759373
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63073330
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55671703
24Gastric acid secretion_Homo sapiens_hsa049711.55426200
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52835374
26Insulin secretion_Homo sapiens_hsa049111.42367460
27Ether lipid metabolism_Homo sapiens_hsa005651.39987243
28Gap junction_Homo sapiens_hsa045401.39216322
29Renin secretion_Homo sapiens_hsa049241.36413256
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35071815
31Collecting duct acid secretion_Homo sapiens_hsa049661.31430461
32Oxytocin signaling pathway_Homo sapiens_hsa049211.30759167
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26946627
34Phototransduction_Homo sapiens_hsa047441.26241198
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24311718
36GnRH signaling pathway_Homo sapiens_hsa049121.19045780
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18579192
38ErbB signaling pathway_Homo sapiens_hsa040121.17794753
39Fatty acid elongation_Homo sapiens_hsa000621.16197221
40Calcium signaling pathway_Homo sapiens_hsa040201.15804436
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13182416
42Cardiac muscle contraction_Homo sapiens_hsa042601.04227937
43cAMP signaling pathway_Homo sapiens_hsa040241.03348325
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.97246402
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96301965
46Renal cell carcinoma_Homo sapiens_hsa052110.96166569
47Melanogenesis_Homo sapiens_hsa049160.93243612
48Vibrio cholerae infection_Homo sapiens_hsa051100.93129350
49Estrogen signaling pathway_Homo sapiens_hsa049150.91127870
50Alzheimers disease_Homo sapiens_hsa050100.90669900
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.89984868
52Oxidative phosphorylation_Homo sapiens_hsa001900.89536359
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89225360
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.85480902
55Ras signaling pathway_Homo sapiens_hsa040140.85328084
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84774713
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84252377
58Type II diabetes mellitus_Homo sapiens_hsa049300.83685967
59Dorso-ventral axis formation_Homo sapiens_hsa043200.82906441
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81192761
61Choline metabolism in cancer_Homo sapiens_hsa052310.80771586
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80239159
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78364873
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78201213
65Glioma_Homo sapiens_hsa052140.77602631
66Bile secretion_Homo sapiens_hsa049760.73554446
67Butanoate metabolism_Homo sapiens_hsa006500.73289531
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72698220
69Pancreatic secretion_Homo sapiens_hsa049720.71438887
70Parkinsons disease_Homo sapiens_hsa050120.70934110
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70077067
72MAPK signaling pathway_Homo sapiens_hsa040100.70007280
73Alcoholism_Homo sapiens_hsa050340.69255822
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67637412
75Endocytosis_Homo sapiens_hsa041440.64994067
76Tight junction_Homo sapiens_hsa045300.63679877
77Ovarian steroidogenesis_Homo sapiens_hsa049130.63518252
78Nitrogen metabolism_Homo sapiens_hsa009100.60523316
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60313608
80Wnt signaling pathway_Homo sapiens_hsa043100.59520080
81Oocyte meiosis_Homo sapiens_hsa041140.57520062
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57190761
83Hedgehog signaling pathway_Homo sapiens_hsa043400.56440077
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55664137
85Hippo signaling pathway_Homo sapiens_hsa043900.55282220
86Sphingolipid metabolism_Homo sapiens_hsa006000.53602849
87Basal cell carcinoma_Homo sapiens_hsa052170.50926955
88Rap1 signaling pathway_Homo sapiens_hsa040150.50742386
89VEGF signaling pathway_Homo sapiens_hsa043700.47455226
90Dilated cardiomyopathy_Homo sapiens_hsa054140.47073718
91Prion diseases_Homo sapiens_hsa050200.46082755
92Thyroid hormone synthesis_Homo sapiens_hsa049180.44581450
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41619789
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41219767
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38638937
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.38415009
97Notch signaling pathway_Homo sapiens_hsa043300.37751713
98Huntingtons disease_Homo sapiens_hsa050160.37742565
99Endometrial cancer_Homo sapiens_hsa052130.36335431
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.35169876
101Chemokine signaling pathway_Homo sapiens_hsa040620.34968424
102Glucagon signaling pathway_Homo sapiens_hsa049220.34648802
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34623946
104Vitamin B6 metabolism_Homo sapiens_hsa007500.33406291
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32741687
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32705303
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32585996
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32584562
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31825166
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31787849
111AMPK signaling pathway_Homo sapiens_hsa041520.30637299
112Colorectal cancer_Homo sapiens_hsa052100.30493695
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28312521
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27303774
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26910620
116Circadian rhythm_Homo sapiens_hsa047100.26751877
117Inositol phosphate metabolism_Homo sapiens_hsa005620.26498025

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