ELAVL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.75433191
2behavioral response to nicotine (GO:0035095)5.07727040
3synaptic vesicle exocytosis (GO:0016079)5.04443089
4vocalization behavior (GO:0071625)4.92056874
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66972212
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59557118
7protein localization to synapse (GO:0035418)4.57002708
8neuron recognition (GO:0008038)4.54088389
9cell migration in hindbrain (GO:0021535)4.46166141
10glutamate secretion (GO:0014047)4.26002990
11pyrimidine nucleobase catabolic process (GO:0006208)4.18950715
12regulation of synaptic vesicle exocytosis (GO:2000300)4.13827920
13neuronal action potential propagation (GO:0019227)4.13125125
14axonal fasciculation (GO:0007413)4.10219789
15regulation of glutamate receptor signaling pathway (GO:1900449)4.09297087
16presynaptic membrane assembly (GO:0097105)4.08918881
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06866190
18establishment of mitochondrion localization (GO:0051654)4.04951793
19presynaptic membrane organization (GO:0097090)4.00993437
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97044798
21negative regulation of microtubule polymerization (GO:0031115)3.90170326
22neurotransmitter secretion (GO:0007269)3.87910138
23positive regulation of synapse assembly (GO:0051965)3.86106136
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.84502404
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79486129
26auditory behavior (GO:0031223)3.77331807
27layer formation in cerebral cortex (GO:0021819)3.76449133
28proline transport (GO:0015824)3.72136195
29postsynaptic membrane organization (GO:0001941)3.68893777
30neuron-neuron synaptic transmission (GO:0007270)3.63495819
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60953348
32regulation of synaptic vesicle transport (GO:1902803)3.60151991
33glutamate receptor signaling pathway (GO:0007215)3.59935820
34synaptic vesicle maturation (GO:0016188)3.55633581
35dendritic spine morphogenesis (GO:0060997)3.51954443
36synaptic transmission, glutamatergic (GO:0035249)3.51789129
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48729596
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47898182
39substrate-independent telencephalic tangential migration (GO:0021826)3.46513693
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.46513693
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.46187285
42nucleobase catabolic process (GO:0046113)3.45528899
43exploration behavior (GO:0035640)3.44958072
44mitochondrion transport along microtubule (GO:0047497)3.44929454
45establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.44929454
46mating behavior (GO:0007617)3.40770026
47locomotory exploration behavior (GO:0035641)3.38668309
48cerebellar Purkinje cell differentiation (GO:0021702)3.38210825
49neurotransmitter-gated ion channel clustering (GO:0072578)3.37179083
50synapse assembly (GO:0007416)3.36756547
51central nervous system neuron axonogenesis (GO:0021955)3.32625909
52neuronal ion channel clustering (GO:0045161)3.32319072
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.31520008
54neurotransmitter transport (GO:0006836)3.30531541
55positive regulation of synapse maturation (GO:0090129)3.30258533
56regulation of synapse assembly (GO:0051963)3.28228019
57retinal ganglion cell axon guidance (GO:0031290)3.26614883
58negative regulation of dendrite morphogenesis (GO:0050774)3.26383324
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.26046681
60innervation (GO:0060384)3.25422826
61neuromuscular synaptic transmission (GO:0007274)3.24656272
62gamma-aminobutyric acid signaling pathway (GO:0007214)3.23879950
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22513079
64adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.20511438
65negative regulation of dendrite development (GO:2000171)3.18193544
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15259702
67regulation of neuronal synaptic plasticity (GO:0048168)3.10429241
68regulation of respiratory system process (GO:0044065)3.10306478
69dendrite development (GO:0016358)3.09083679
70regulation of neurotransmitter levels (GO:0001505)3.07333838
71startle response (GO:0001964)3.06938645
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.06334640
73synaptic vesicle endocytosis (GO:0048488)3.06052085
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05754732
75membrane depolarization during action potential (GO:0086010)3.04438046
76regulation of postsynaptic membrane potential (GO:0060078)3.03543690
77adult walking behavior (GO:0007628)3.03284535
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.02533605
79regulation of vesicle fusion (GO:0031338)3.01500864
80response to histamine (GO:0034776)3.00484439
81protein localization to cilium (GO:0061512)2.99850769
82transmission of nerve impulse (GO:0019226)2.99840484
83forebrain neuron differentiation (GO:0021879)2.99536505
84dopamine biosynthetic process (GO:0042416)2.98926990
85dendrite morphogenesis (GO:0048813)2.98363674
86regulation of synapse structural plasticity (GO:0051823)2.97776732
87gamma-aminobutyric acid transport (GO:0015812)2.97765850
88ganglion development (GO:0061548)2.94954376
89synaptic transmission, cholinergic (GO:0007271)2.94709306
90synaptic vesicle transport (GO:0048489)2.94048403
91establishment of synaptic vesicle localization (GO:0097480)2.94048403
92olfactory bulb development (GO:0021772)2.92701463
93regulation of feeding behavior (GO:0060259)2.92654463
94axon extension (GO:0048675)2.92635608
95regulation of respiratory gaseous exchange (GO:0043576)2.92230347
96sympathetic nervous system development (GO:0048485)2.92088629
97hippocampus development (GO:0021766)2.91702908
98central nervous system projection neuron axonogenesis (GO:0021952)2.91500891
99behavioral response to ethanol (GO:0048149)2.89752569
100neuronal action potential (GO:0019228)2.89751766
101response to auditory stimulus (GO:0010996)2.89731351
102membrane depolarization (GO:0051899)2.89682958
103regulation of neurotransmitter secretion (GO:0046928)2.89370005
104prepulse inhibition (GO:0060134)2.88211242
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87964770
106regulation of synapse organization (GO:0050807)2.84837546
107mechanosensory behavior (GO:0007638)2.83602768
108protein polyglutamylation (GO:0018095)2.83154584
109regulation of synapse maturation (GO:0090128)2.83143462
110regulation of glutamate secretion (GO:0014048)2.83070474
111synapse organization (GO:0050808)2.82549691
112energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82283901
113ATP hydrolysis coupled proton transport (GO:0015991)2.82283901
114cerebral cortex radially oriented cell migration (GO:0021799)2.81297725
115positive regulation of gastrulation (GO:2000543)2.80022622
116regulation of synaptic transmission, GABAergic (GO:0032228)2.79821375
117detection of calcium ion (GO:0005513)2.79271970
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78683296
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77673700
120intraspecies interaction between organisms (GO:0051703)2.77508701
121social behavior (GO:0035176)2.77508701
122regulation of cAMP-dependent protein kinase activity (GO:2000479)2.77472451
123long-term memory (GO:0007616)2.76803529
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76148545
125behavioral fear response (GO:0001662)2.75854978
126behavioral defense response (GO:0002209)2.75854978
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75354794
128membrane hyperpolarization (GO:0060081)2.75258609
129synaptic transmission (GO:0007268)2.75196851
130neurofilament cytoskeleton organization (GO:0060052)2.75149156
131regulation of dendritic spine morphogenesis (GO:0061001)2.74824659
132fear response (GO:0042596)2.73532789
133negative regulation of axon extension (GO:0030517)2.73522733
134adult behavior (GO:0030534)2.73271162
135cell differentiation in hindbrain (GO:0021533)2.72731000
136negative regulation of axonogenesis (GO:0050771)2.72541478
137spinal cord development (GO:0021510)2.72075394
138neuron migration (GO:0001764)2.68005844
139peristalsis (GO:0030432)2.67642016
140neuron maturation (GO:0042551)2.66754928
141behavioral response to cocaine (GO:0048148)2.66469043
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66206679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05522800
2GBX2_23144817_ChIP-Seq_PC3_Human3.93615815
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04622473
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04531388
5TAF15_26573619_Chip-Seq_HEK293_Human2.88782264
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84626204
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.83315092
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58190172
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57327285
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57327285
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.54634747
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53045815
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50515349
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.49257726
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49231240
16* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37002998
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36769533
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.35832184
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34948412
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33248630
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20173209
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18342169
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17142076
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.13227767
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13111798
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12588537
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.11352362
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.08263049
29* REST_18959480_ChIP-ChIP_MESCs_Mouse2.00330173
30IGF1R_20145208_ChIP-Seq_DFB_Human2.00156844
31VDR_22108803_ChIP-Seq_LS180_Human1.91889809
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91776297
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85831188
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84934312
35P300_19829295_ChIP-Seq_ESCs_Human1.84436356
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84009452
37RNF2_27304074_Chip-Seq_NSC_Mouse1.74545512
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71095830
39ZNF274_21170338_ChIP-Seq_K562_Hela1.70843211
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.69863983
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67654819
42AR_21572438_ChIP-Seq_LNCaP_Human1.67368088
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65851090
44* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58384912
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.54245681
46DROSHA_22980978_ChIP-Seq_HELA_Human1.53013937
47FUS_26573619_Chip-Seq_HEK293_Human1.48351732
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.47718359
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46144671
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46033405
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45763921
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44934734
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44244582
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.42105001
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35322645
56* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32862124
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31986987
58AR_25329375_ChIP-Seq_VCAP_Human1.31768216
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29464033
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.28832955
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28698517
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28694434
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27390447
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26426865
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25549342
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.22146562
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21689409
68ER_23166858_ChIP-Seq_MCF-7_Human1.19264706
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17425962
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17425962
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16739909
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.15096434
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.13725388
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.12929387
75* STAT3_23295773_ChIP-Seq_U87_Human1.11046305
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10958789
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.09810953
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.09039133
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07507684
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07405288
81AHR_22903824_ChIP-Seq_MCF-7_Human1.07403868
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06348664
83CBP_20019798_ChIP-Seq_JUKART_Human1.06348664
84* JUN_21703547_ChIP-Seq_K562_Human1.05959295
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05943719
86TCF4_23295773_ChIP-Seq_U87_Human1.05025663
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.03876317
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03515948
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03362168
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03089716
91* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02981448
92BCAT_22108803_ChIP-Seq_LS180_Human1.02054673
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00845293
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00185032
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98355021
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98247808
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98033706
98TP53_20018659_ChIP-ChIP_R1E_Mouse0.96962702
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.96507804
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96215208
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95569206
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95484153
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.94857264
104KDM2B_26808549_Chip-Seq_REH_Human0.94576856
105AR_19668381_ChIP-Seq_PC3_Human0.94136675
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93685421
107EWS_26573619_Chip-Seq_HEK293_Human0.92841319
108TP53_18474530_ChIP-ChIP_U2OS_Human0.92160595
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92086575
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.90275339
111* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88928050
112SOX9_26525672_Chip-Seq_HEART_Mouse0.88618999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.85671059
2MP0004859_abnormal_synaptic_plasticity4.06986663
3MP0006276_abnormal_autonomic_nervous3.62625469
4MP0004270_analgesia3.38580485
5MP0003635_abnormal_synaptic_transmissio3.27307242
6MP0001968_abnormal_touch/_nociception3.24434768
7MP0002735_abnormal_chemical_nociception3.20193306
8MP0005423_abnormal_somatic_nervous2.87070878
9MP0009745_abnormal_behavioral_response2.79534264
10MP0002734_abnormal_mechanical_nocicepti2.78967905
11MP0002063_abnormal_learning/memory/cond2.76170600
12MP0002736_abnormal_nociception_after2.73634784
13MP0009046_muscle_twitch2.71581459
14MP0002064_seizures2.64453308
15MP0002572_abnormal_emotion/affect_behav2.59581260
16MP0002184_abnormal_innervation2.43316704
17MP0000778_abnormal_nervous_system2.39142763
18MP0002272_abnormal_nervous_system2.33223422
19MP0002733_abnormal_thermal_nociception2.30556546
20MP0001529_abnormal_vocalization2.21990292
21MP0001440_abnormal_grooming_behavior2.12441923
22MP0001486_abnormal_startle_reflex2.09724600
23MP0001970_abnormal_pain_threshold2.09340829
24MP0003122_maternal_imprinting2.06979768
25* MP0002067_abnormal_sensory_capabilities2.05833724
26MP0002557_abnormal_social/conspecific_i1.88516236
27MP0001905_abnormal_dopamine_level1.87289086
28MP0001188_hyperpigmentation1.85724054
29MP0005645_abnormal_hypothalamus_physiol1.85509417
30MP0003787_abnormal_imprinting1.85017511
31MP0001501_abnormal_sleep_pattern1.82901018
32MP0004924_abnormal_behavior1.76927570
33MP0005386_behavior/neurological_phenoty1.76927570
34MP0000955_abnormal_spinal_cord1.69352089
35MP0002751_abnormal_autonomic_nervous1.68605523
36* MP0004811_abnormal_neuron_physiology1.64318086
37MP0001984_abnormal_olfaction1.62231585
38MP0004858_abnormal_nervous_system1.60381858
39MP0002822_catalepsy1.54106005
40MP0008877_abnormal_DNA_methylation1.52491245
41* MP0002882_abnormal_neuron_morphology1.49394760
42MP0005646_abnormal_pituitary_gland1.48326937
43MP0004142_abnormal_muscle_tone1.43685126
44MP0010386_abnormal_urinary_bladder1.38408574
45MP0002909_abnormal_adrenal_gland1.36360113
46MP0002837_dystrophic_cardiac_calcinosis1.35703131
47MP0004742_abnormal_vestibular_system1.32902524
48* MP0002066_abnormal_motor_capabilities/c1.32241494
49MP0001986_abnormal_taste_sensitivity1.31541469
50MP0008569_lethality_at_weaning1.29962823
51MP0003123_paternal_imprinting1.27207361
52MP0000566_synostosis1.24458322
53MP0005499_abnormal_olfactory_system1.23831224
54MP0005394_taste/olfaction_phenotype1.23831224
55MP0000631_abnormal_neuroendocrine_gland1.17018449
56MP0002152_abnormal_brain_morphology1.16752890
57MP0005253_abnormal_eye_physiology1.12947886
58MP0001502_abnormal_circadian_rhythm1.12863103
59MP0002752_abnormal_somatic_nervous1.10487536
60MP0003121_genomic_imprinting1.09985193
61MP0000569_abnormal_digit_pigmentation1.09241060
62MP0008789_abnormal_olfactory_epithelium1.06835170
63MP0003329_amyloid_beta_deposits1.04750730
64MP0003879_abnormal_hair_cell1.02283810
65MP0002234_abnormal_pharynx_morphology1.01549432
66MP0002638_abnormal_pupillary_reflex0.99855225
67MP0003011_delayed_dark_adaptation0.98833623
68MP0003119_abnormal_digestive_system0.97784932
69MP0001963_abnormal_hearing_physiology0.97688293
70MP0000751_myopathy0.97675621
71MP0002102_abnormal_ear_morphology0.97457104
72MP0002069_abnormal_eating/drinking_beha0.93693832
73MP0009780_abnormal_chondrocyte_physiolo0.93054109
74MP0008995_early_reproductive_senescence0.92242055
75MP0009379_abnormal_foot_pigmentation0.91553245
76MP0000026_abnormal_inner_ear0.89540276
77MP0000049_abnormal_middle_ear0.89291331
78MP0002876_abnormal_thyroid_physiology0.89053028
79MP0004085_abnormal_heartbeat0.88279548
80MP0006072_abnormal_retinal_apoptosis0.87433933
81MP0002229_neurodegeneration0.86830546
82* MP0003861_abnormal_nervous_system0.85162417
83MP0000538_abnormal_urinary_bladder0.84141342
84MP0008872_abnormal_physiological_respon0.83478493
85MP0002928_abnormal_bile_duct0.83222207
86MP0005195_abnormal_posterior_eye0.82150895
87MP0004145_abnormal_muscle_electrophysio0.79882811
88MP0005551_abnormal_eye_electrophysiolog0.79435189
89MP0003183_abnormal_peptide_metabolism0.77745140
90MP0004885_abnormal_endolymph0.76607783
91MP0003938_abnormal_ear_development0.76225250
92MP0005535_abnormal_body_temperature0.73969495
93MP0003631_nervous_system_phenotype0.73705757
94MP0001664_abnormal_digestion0.73247758
95MP0001299_abnormal_eye_distance/0.72601258
96MP0002653_abnormal_ependyma_morphology0.72491043
97MP0003137_abnormal_impulse_conducting0.72085140
98MP0003633_abnormal_nervous_system0.71855805
99MP0005187_abnormal_penis_morphology0.70714676
100MP0003634_abnormal_glial_cell0.70187841
101MP0005409_darkened_coat_color0.69761958
102MP0001943_abnormal_respiration0.69489637
103MP0006292_abnormal_olfactory_placode0.68543667
104MP0003283_abnormal_digestive_organ0.67304744
105MP0002081_perinatal_lethality0.65181450
106MP0002938_white_spotting0.63205757
107MP0002082_postnatal_lethality0.61019706
108MP0010770_preweaning_lethality0.61019706
109MP0001485_abnormal_pinna_reflex0.60677425
110MP0002163_abnormal_gland_morphology0.60173535
111MP0003632_abnormal_nervous_system0.60029592
112MP0003890_abnormal_embryonic-extraembry0.58059839
113MP0004133_heterotaxia0.58009051
114MP0003315_abnormal_perineum_morphology0.56885813

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.06162396
2Atonic seizures (HP:0010819)5.15029262
3Myokymia (HP:0002411)4.85201655
4Focal seizures (HP:0007359)4.80301072
5Febrile seizures (HP:0002373)4.62890916
6Limb dystonia (HP:0002451)4.44089099
7Epileptic encephalopathy (HP:0200134)4.13279910
8Hyperventilation (HP:0002883)4.05147858
9Absence seizures (HP:0002121)3.89420302
10Progressive cerebellar ataxia (HP:0002073)3.87710308
11Visual hallucinations (HP:0002367)3.86141584
12Pheochromocytoma (HP:0002666)3.61883245
13Dialeptic seizures (HP:0011146)3.56882255
14Amblyopia (HP:0000646)3.51865021
15Hypothermia (HP:0002045)3.46153869
16Neuroendocrine neoplasm (HP:0100634)3.28489860
17Broad-based gait (HP:0002136)3.28244632
18Generalized tonic-clonic seizures (HP:0002069)3.22044095
19Failure to thrive in infancy (HP:0001531)3.13572321
20Polyphagia (HP:0002591)2.98162489
21Acute necrotizing encephalopathy (HP:0006965)2.95840449
22Abnormal hair whorl (HP:0010721)2.94133777
23Progressive inability to walk (HP:0002505)2.91987531
24Gait imbalance (HP:0002141)2.90307533
25Nephronophthisis (HP:0000090)2.83566517
26Pachygyria (HP:0001302)2.77037709
27Molar tooth sign on MRI (HP:0002419)2.74507085
28Abnormality of midbrain morphology (HP:0002418)2.74507085
29Progressive macrocephaly (HP:0004481)2.72724891
30Truncal ataxia (HP:0002078)2.69768777
31Exotropia (HP:0000577)2.66983225
32Excessive salivation (HP:0003781)2.65991839
33Drooling (HP:0002307)2.65991839
34Cortical dysplasia (HP:0002539)2.65586011
35Retinal dysplasia (HP:0007973)2.63929839
36Abnormal mitochondria in muscle tissue (HP:0008316)2.63843025
37Abnormal eating behavior (HP:0100738)2.59384478
38Medial flaring of the eyebrow (HP:0010747)2.59300259
39Termporal pattern (HP:0011008)2.59270694
40Insidious onset (HP:0003587)2.59270694
41Agitation (HP:0000713)2.58764607
42Action tremor (HP:0002345)2.55396629
43True hermaphroditism (HP:0010459)2.51219645
44Pancreatic fibrosis (HP:0100732)2.50420809
45Supranuclear gaze palsy (HP:0000605)2.50380165
46Hypoventilation (HP:0002791)2.48359268
47Pancreatic cysts (HP:0001737)2.46215997
48Hypoplasia of the brainstem (HP:0002365)2.45378825
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.45378825
50Esotropia (HP:0000565)2.43214324
51Congenital primary aphakia (HP:0007707)2.42874906
52Epileptiform EEG discharges (HP:0011182)2.42798690
53Poor suck (HP:0002033)2.39777620
54Hyperthyroidism (HP:0000836)2.39728587
55Ankle clonus (HP:0011448)2.38616538
56Inability to walk (HP:0002540)2.36758725
57Specific learning disability (HP:0001328)2.35341893
58EEG with generalized epileptiform discharges (HP:0011198)2.34721719
59Abnormality of the corticospinal tract (HP:0002492)2.33534270
60Hepatoblastoma (HP:0002884)2.30667145
61Fetal akinesia sequence (HP:0001989)2.28837548
62Nephrogenic diabetes insipidus (HP:0009806)2.28651673
63Protruding tongue (HP:0010808)2.27864450
64Abnormality of the renal medulla (HP:0100957)2.27253177
65Gaze-evoked nystagmus (HP:0000640)2.27092485
66Genital tract atresia (HP:0001827)2.26927219
67Anxiety (HP:0000739)2.26895071
68Ulnar claw (HP:0001178)2.25314988
69Spastic tetraplegia (HP:0002510)2.24943649
70Mitochondrial inheritance (HP:0001427)2.23523994
71Abnormality of the lower motor neuron (HP:0002366)2.23096614
72Hypsarrhythmia (HP:0002521)2.23075770
73Type II lissencephaly (HP:0007260)2.21636530
74Impaired vibration sensation in the lower limbs (HP:0002166)2.19608445
75Vaginal atresia (HP:0000148)2.19170014
76Narrow nasal bridge (HP:0000446)2.15762992
77Genetic anticipation (HP:0003743)2.15604538
78Poor eye contact (HP:0000817)2.12369201
79Mutism (HP:0002300)2.12358123
80Urinary urgency (HP:0000012)2.10986586
81Lissencephaly (HP:0001339)2.10948675
82Absent speech (HP:0001344)2.08409810
83Acute encephalopathy (HP:0006846)2.05954000
84Abnormality of the labia minora (HP:0012880)2.04043875
85Shoulder girdle muscle weakness (HP:0003547)2.03218806
86Status epilepticus (HP:0002133)2.01948161
87Poor coordination (HP:0002370)1.99503835
88Intestinal atresia (HP:0011100)1.98031844
89Abnormality of the parathyroid morphology (HP:0011766)1.95841680
90Amyotrophic lateral sclerosis (HP:0007354)1.95262495
91Spastic gait (HP:0002064)1.95250945
92Pendular nystagmus (HP:0012043)1.95202940
93Impaired pain sensation (HP:0007328)1.95138676
94Abnormality of pain sensation (HP:0010832)1.95138676
95Chronic hepatic failure (HP:0100626)1.92097201
96Depression (HP:0000716)1.91462190
97Oligodactyly (hands) (HP:0001180)1.90552739
98Aqueductal stenosis (HP:0002410)1.90407392
99Anosmia (HP:0000458)1.89972487
100Morphological abnormality of the pyramidal tract (HP:0002062)1.89961927
101Polymicrogyria (HP:0002126)1.88212957
102Abnormal social behavior (HP:0012433)1.88190874
103Impaired social interactions (HP:0000735)1.88190874
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86979722
105Abnormality of salivation (HP:0100755)1.86847700
106Narrow forehead (HP:0000341)1.85580096
107Optic disc pallor (HP:0000543)1.84724629
108Hemiparesis (HP:0001269)1.83949526
109Urinary bladder sphincter dysfunction (HP:0002839)1.83730960
110Hypoplasia of the corpus callosum (HP:0002079)1.80813369
111Delayed gross motor development (HP:0002194)1.80269545
112Akinesia (HP:0002304)1.80081626
113Blue irides (HP:0000635)1.79498190
114Muscular hypotonia of the trunk (HP:0008936)1.79249640
115Bony spicule pigmentary retinopathy (HP:0007737)1.78940865
116Intellectual disability, severe (HP:0010864)1.77869943
117Delusions (HP:0000746)1.77800434
118Thyroid-stimulating hormone excess (HP:0002925)1.77065249
119Sleep apnea (HP:0010535)1.75943743
120Neoplasm of the peripheral nervous system (HP:0100007)1.75868770
121Increased CSF lactate (HP:0002490)1.74291786
122Patellar aplasia (HP:0006443)1.74222325
123Oligomenorrhea (HP:0000876)1.71739729
124Scanning speech (HP:0002168)1.71662321
125Volvulus (HP:0002580)1.70924126
126Cystic liver disease (HP:0006706)1.70534328
127Optic nerve hypoplasia (HP:0000609)1.70152581
128Anencephaly (HP:0002323)1.70131881
129Dysdiadochokinesis (HP:0002075)1.69662754
130Postaxial hand polydactyly (HP:0001162)1.69602397
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.69362707
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69362707
133Labial hypoplasia (HP:0000066)1.69348380
134Torticollis (HP:0000473)1.69194073
135Occipital encephalocele (HP:0002085)1.69054721
136Autism (HP:0000717)1.69033530
137Congenital stationary night blindness (HP:0007642)1.68605768
138Psychosis (HP:0000709)1.67725510
139Abnormal pancreas size (HP:0012094)1.66821646
140Generalized hypotonia (HP:0001290)1.66590205
141Growth hormone deficiency (HP:0000824)1.65360559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.35840087
2MARK14.22459364
3NTRK33.64219230
4MAP3K43.23498554
5MAP2K73.12447562
6MAP3K123.00718099
7MINK12.55723871
8MAP3K92.43813993
9MAPK132.39250523
10PNCK2.31127911
11NTRK22.23550544
12EPHA42.05195468
13PLK22.03305484
14MAP2K41.95562375
15MAP4K21.88482842
16GRK51.81485782
17FRK1.80374547
18TRIM281.75200962
19PINK11.67175888
20KSR11.65507258
21ERBB31.65060913
22DAPK21.58074291
23UHMK11.54846224
24DYRK21.54137227
25CDK191.53448047
26NTRK11.48390716
27SIK21.40012722
28PAK61.35370695
29TNIK1.31272421
30CDK51.27290000
31SIK31.22707684
32BMPR1B1.21652952
33DYRK31.20124155
34DAPK11.19048921
35CSNK1G21.18399651
36BCR1.14979743
37NME11.09955875
38PRKCG1.09698713
39PHKG21.06147772
40PHKG11.06147772
41CAMK2A1.04450396
42ARAF1.04345412
43RIPK41.04321881
44WNK31.04286874
45SGK2231.01241622
46SGK4941.01241622
47BMPR21.00960726
48DYRK1B1.00551818
49CSNK1G30.98900616
50AKT30.98416596
51GRK70.94383723
52OXSR10.94276449
53DYRK1A0.92160208
54KSR20.91209491
55CDK140.90503439
56CDK180.90463681
57CAMK2B0.89818583
58LIMK10.88347907
59CCNB10.86713741
60ADRBK20.86413334
61ADRBK10.83519141
62CDK150.82425005
63LATS20.81433076
64SGK20.81238242
65PAK30.80235534
66GRK10.79218780
67EPHB20.78663367
68PRPF4B0.78080694
69INSRR0.74084794
70CDK11A0.72216292
71PRKCE0.71540047
72YES10.65187807
73MAPK150.62300720
74CAMKK20.61774041
75CAMK10.60954608
76RET0.60550315
77CAMK40.60544079
78RPS6KA20.58573683
79MAP3K20.58048125
80FGR0.57976505
81STK160.56097006
82CSNK1G10.55687328
83BRAF0.55489911
84FGFR20.53287722
85CAMK2D0.51781294
86FES0.50421199
87MAP2K10.49086808
88PRKAA10.48856598
89CSNK1E0.48453159
90FER0.48259720
91ROCK20.47968036
92PRKCZ0.47552256
93EPHA30.47455537
94PTK2B0.47402643
95ZAK0.46210917
96CAMK1G0.45810520
97PKN10.45170750
98STK110.45074911
99CAMK2G0.43895373
100MAP3K60.43745707
101CSNK1A1L0.43245826
102CSNK1D0.42617964
103MKNK20.41976627
104PRKACA0.41670713
105TSSK60.41622380
106CAMKK10.41416148
107ERBB40.41056533
108TAOK10.40740573
109SGK10.40327008
110ERBB20.40093765
111STK390.39117556
112TLK10.38968818
113PRKG10.38477504
114MAPKAPK50.38309443
115WNK40.38225867
116CDK30.37082346
117LMTK20.36516172
118CSNK1A10.36103479
119MUSK0.35091298
120SGK30.34611820
121TYRO30.34486751
122PRKACB0.34347760
123MARK20.33658662
124RPS6KA40.31967072
125PRKCB0.31379557
126MAPK80.31359944
127PRKCH0.31117046
128RPS6KA30.30848205
129MAPK40.29665957
130MAPK90.28097282
131GSK3B0.26241662

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.12349962
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69861433
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67452198
4Collecting duct acid secretion_Homo sapiens_hsa049662.65203379
5Oxidative phosphorylation_Homo sapiens_hsa001902.60894646
6GABAergic synapse_Homo sapiens_hsa047272.47471158
7Taste transduction_Homo sapiens_hsa047422.31398585
8Olfactory transduction_Homo sapiens_hsa047402.28703149
9Amphetamine addiction_Homo sapiens_hsa050312.27385203
10Dopaminergic synapse_Homo sapiens_hsa047282.27097544
11Glutamatergic synapse_Homo sapiens_hsa047242.23582047
12Circadian entrainment_Homo sapiens_hsa047132.23137340
13Morphine addiction_Homo sapiens_hsa050322.22169522
14Long-term potentiation_Homo sapiens_hsa047202.17816399
15Parkinsons disease_Homo sapiens_hsa050122.15640465
16Serotonergic synapse_Homo sapiens_hsa047262.11429356
17Alzheimers disease_Homo sapiens_hsa050101.85893336
18Cocaine addiction_Homo sapiens_hsa050301.84455744
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83865997
20Insulin secretion_Homo sapiens_hsa049111.83622355
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81985998
22Vibrio cholerae infection_Homo sapiens_hsa051101.75848741
23Long-term depression_Homo sapiens_hsa047301.74251489
24Cholinergic synapse_Homo sapiens_hsa047251.73646766
25Cardiac muscle contraction_Homo sapiens_hsa042601.64094339
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.62808239
27Salivary secretion_Homo sapiens_hsa049701.59710686
28Axon guidance_Homo sapiens_hsa043601.58396269
29Renin secretion_Homo sapiens_hsa049241.53344258
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48616679
31Huntingtons disease_Homo sapiens_hsa050161.46501271
32Gastric acid secretion_Homo sapiens_hsa049711.39451488
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39105776
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36517797
35Gap junction_Homo sapiens_hsa045401.34084046
36Calcium signaling pathway_Homo sapiens_hsa040201.29769307
37Phototransduction_Homo sapiens_hsa047441.25718742
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25584561
39Oxytocin signaling pathway_Homo sapiens_hsa049211.25383397
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24136741
41GnRH signaling pathway_Homo sapiens_hsa049121.14570526
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13046650
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12692196
44Protein export_Homo sapiens_hsa030601.11890499
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11568627
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10796936
47ErbB signaling pathway_Homo sapiens_hsa040120.99506443
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91709793
49Melanogenesis_Homo sapiens_hsa049160.91133215
50Estrogen signaling pathway_Homo sapiens_hsa049150.89628549
51Steroid biosynthesis_Homo sapiens_hsa001000.88258741
52Ether lipid metabolism_Homo sapiens_hsa005650.87490966
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87130331
54cAMP signaling pathway_Homo sapiens_hsa040240.84300280
55Alcoholism_Homo sapiens_hsa050340.81642145
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81299986
57Glioma_Homo sapiens_hsa052140.79777784
58Type II diabetes mellitus_Homo sapiens_hsa049300.78562544
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78018888
60Oocyte meiosis_Homo sapiens_hsa041140.77641899
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76568434
62Phagosome_Homo sapiens_hsa041450.74214492
63Linoleic acid metabolism_Homo sapiens_hsa005910.73135421
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70997301
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70726178
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69747613
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69489368
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67197514
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.64719027
70MAPK signaling pathway_Homo sapiens_hsa040100.62705110
71Dorso-ventral axis formation_Homo sapiens_hsa043200.60697049
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60621323
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60220852
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57879437
75Rheumatoid arthritis_Homo sapiens_hsa053230.57803493
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52503027
77Wnt signaling pathway_Homo sapiens_hsa043100.52357351
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50382033
79Basal transcription factors_Homo sapiens_hsa030220.50271421
80Ovarian steroidogenesis_Homo sapiens_hsa049130.49458913
81Type I diabetes mellitus_Homo sapiens_hsa049400.48926945
82Ras signaling pathway_Homo sapiens_hsa040140.48926367
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48662048
84Endometrial cancer_Homo sapiens_hsa052130.46769981
85Pancreatic secretion_Homo sapiens_hsa049720.46651249
86Butanoate metabolism_Homo sapiens_hsa006500.46498617
87Tryptophan metabolism_Homo sapiens_hsa003800.46471419
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46349362
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46100295
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.45951474
91Glucagon signaling pathway_Homo sapiens_hsa049220.45748070
92Regulation of autophagy_Homo sapiens_hsa041400.44475790
93Hippo signaling pathway_Homo sapiens_hsa043900.43408206
94Thyroid hormone synthesis_Homo sapiens_hsa049180.43398469
95Renal cell carcinoma_Homo sapiens_hsa052110.43072949
96Selenocompound metabolism_Homo sapiens_hsa004500.41887679
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41649654
98Melanoma_Homo sapiens_hsa052180.41523743
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40762948
100Basal cell carcinoma_Homo sapiens_hsa052170.39981591
101Dilated cardiomyopathy_Homo sapiens_hsa054140.39102172
102Choline metabolism in cancer_Homo sapiens_hsa052310.38933793
103Colorectal cancer_Homo sapiens_hsa052100.38240677
104Peroxisome_Homo sapiens_hsa041460.36999730
105Insulin signaling pathway_Homo sapiens_hsa049100.36869634
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36572251
107Hedgehog signaling pathway_Homo sapiens_hsa043400.35213223
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.34232285
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.34224861
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.34057017
111Prion diseases_Homo sapiens_hsa050200.33436010
112Bile secretion_Homo sapiens_hsa049760.32414298
113Rap1 signaling pathway_Homo sapiens_hsa040150.31485111
114VEGF signaling pathway_Homo sapiens_hsa043700.28847123
115Nitrogen metabolism_Homo sapiens_hsa009100.28443108
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27541328
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26587087
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26108357
119Circadian rhythm_Homo sapiens_hsa047100.25850914
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25747237
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24176603
122African trypanosomiasis_Homo sapiens_hsa051430.22328887
123Proteasome_Homo sapiens_hsa030500.22053571
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20815499
125Prolactin signaling pathway_Homo sapiens_hsa049170.19527734

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