ELF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81389485
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81389485
3antigen processing and presentation of endogenous antigen (GO:0019883)5.46094575
4positive regulation of gamma-delta T cell activation (GO:0046645)5.44419435
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68760948
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35651346
7ribosomal small subunit assembly (GO:0000028)4.34369659
8regulation of gamma-delta T cell differentiation (GO:0045586)4.33604574
9positive regulation of B cell differentiation (GO:0045579)4.22901719
10regulation of gamma-delta T cell activation (GO:0046643)4.04654992
11regulation of B cell receptor signaling pathway (GO:0050855)4.01217042
12B cell receptor signaling pathway (GO:0050853)3.85885854
13regulation of B cell differentiation (GO:0045577)3.85679053
14negative T cell selection (GO:0043383)3.72403870
15negative thymic T cell selection (GO:0045060)3.66310629
16positive regulation by symbiont of host defense response (GO:0052509)3.66204562
17modulation by symbiont of host defense response (GO:0052031)3.66204562
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66204562
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66204562
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.66204562
21modulation by symbiont of host immune response (GO:0052553)3.66204562
22response to peptidoglycan (GO:0032494)3.63744764
23positive thymic T cell selection (GO:0045059)3.57785678
24negative regulation of T cell mediated immunity (GO:0002710)3.54900197
25negative regulation of phagocytosis (GO:0050765)3.54681519
26definitive hemopoiesis (GO:0060216)3.52544996
27antigen processing and presentation via MHC class Ib (GO:0002475)3.45870533
28detection of other organism (GO:0098543)3.41709870
29interferon-gamma production (GO:0032609)3.36750416
30negative regulation of interleukin-12 production (GO:0032695)3.31581895
31viral transcription (GO:0019083)3.29548581
32mast cell activation (GO:0045576)3.28228867
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27470243
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25433204
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.25089387
36T cell migration (GO:0072678)3.23086852
37detection of bacterium (GO:0016045)3.23010556
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.21961142
39thymic T cell selection (GO:0045061)3.20703801
40leukocyte aggregation (GO:0070486)3.20042143
41T cell homeostasis (GO:0043029)3.17723267
42hepatocyte apoptotic process (GO:0097284)3.17373167
43regulation of regulatory T cell differentiation (GO:0045589)3.17199752
44negative regulation of T-helper cell differentiation (GO:0045623)3.16990600
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16990600
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16704355
47response to interleukin-15 (GO:0070672)3.16002894
48macrophage activation involved in immune response (GO:0002281)3.14969582
49negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12165858
50translational termination (GO:0006415)3.11203577
51response to type I interferon (GO:0034340)3.09652030
52granulocyte activation (GO:0036230)3.08887422
53myeloid cell activation involved in immune response (GO:0002275)3.06929684
54T cell selection (GO:0045058)3.06413360
55megakaryocyte development (GO:0035855)3.05517674
56type I interferon signaling pathway (GO:0060337)3.03904431
57cellular response to type I interferon (GO:0071357)3.03904431
58immunoglobulin mediated immune response (GO:0016064)3.00376818
59neutrophil activation involved in immune response (GO:0002283)3.00343686
60response to protozoan (GO:0001562)3.00006328
61myeloid dendritic cell activation (GO:0001773)2.99702595
62* regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98225620
63regulation of interferon-beta biosynthetic process (GO:0045357)2.97157127
64antigen receptor-mediated signaling pathway (GO:0050851)2.96987349
65germinal center formation (GO:0002467)2.95477267
66negative regulation of leukocyte mediated immunity (GO:0002704)2.95360987
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94486322
68tolerance induction (GO:0002507)2.92975693
69NIK/NF-kappaB signaling (GO:0038061)2.92045457
70positive T cell selection (GO:0043368)2.90287913
71detection of external biotic stimulus (GO:0098581)2.88342768
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88101394
73lymphocyte homeostasis (GO:0002260)2.88092275
74cellular response to zinc ion (GO:0071294)2.82872641
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82322300
76cellular response to interleukin-15 (GO:0071350)2.81720942
77response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81697839
78response to host immune response (GO:0052572)2.81697839
79negative regulation of B cell proliferation (GO:0030889)2.81610686
80* regulation of T cell receptor signaling pathway (GO:0050856)2.79928602
81defense response to protozoan (GO:0042832)2.79781385
82detection of molecule of bacterial origin (GO:0032490)2.79395393
83microglial cell activation (GO:0001774)2.78862866
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78830844
85leukocyte degranulation (GO:0043299)2.78205251
86regulation of tolerance induction (GO:0002643)2.78044646
87regulation of alpha-beta T cell proliferation (GO:0046640)2.74926489
88angiogenesis involved in wound healing (GO:0060055)2.74563439
89regulation of T-helper 1 cell differentiation (GO:0045625)2.74416113
90cotranslational protein targeting to membrane (GO:0006613)2.74272686
91protein targeting to ER (GO:0045047)2.74153462
92ribosomal small subunit biogenesis (GO:0042274)2.73872288
93regulation of mast cell degranulation (GO:0043304)2.73295636
94interferon-gamma-mediated signaling pathway (GO:0060333)2.72816264
95negative regulation of cell killing (GO:0031342)2.72412247
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72412247
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72288881
98T cell costimulation (GO:0031295)2.72285637
99regulation of natural killer cell mediated immunity (GO:0002715)2.72159839
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72159839
101positive regulation of mast cell activation (GO:0033005)2.72144166
102negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.71893194
103cellular extravasation (GO:0045123)2.71833016
104positive regulation of interleukin-2 production (GO:0032743)2.71808394
105positive regulation of interferon-alpha production (GO:0032727)2.71275005
106regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.70920065
107lymphocyte costimulation (GO:0031294)2.69511012
108regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69317008
109neutrophil activation (GO:0042119)2.68252708
110leukocyte homeostasis (GO:0001776)2.67905275
111G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.67249015
112regulation of granulocyte differentiation (GO:0030852)2.67061409
113T cell receptor signaling pathway (GO:0050852)2.66764935
114positive regulation of tolerance induction (GO:0002645)2.65429666
115regulation of alpha-beta T cell activation (GO:0046634)2.65222671
116positive regulation of isotype switching (GO:0045830)2.64430572
117mature B cell differentiation (GO:0002335)2.64325456
118positive regulation of macrophage differentiation (GO:0045651)2.63465158
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.63058445
120establishment of protein localization to endoplasmic reticulum (GO:0072599)2.60585186
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58733660
122response to muramyl dipeptide (GO:0032495)2.58657813
123mast cell degranulation (GO:0043303)2.58533241
124mast cell activation involved in immune response (GO:0002279)2.58533241
125positive regulation of granulocyte differentiation (GO:0030854)2.58494199
126regulation of B cell apoptotic process (GO:0002902)2.58236638
127regulation of T cell tolerance induction (GO:0002664)2.58127357
128translational elongation (GO:0006414)2.57869715
129natural killer cell activation (GO:0030101)2.57190304
130B cell homeostasis (GO:0001782)2.56704313
131protein localization to endoplasmic reticulum (GO:0070972)2.56084209
132B cell mediated immunity (GO:0019724)2.54111174
133regulation of response to interferon-gamma (GO:0060330)2.54006415
134mature B cell differentiation involved in immune response (GO:0002313)2.53488321
135regulation of necroptotic process (GO:0060544)2.51420102
136positive regulation of B cell activation (GO:0050871)2.51201853
137negative regulation of erythrocyte differentiation (GO:0045647)2.50733836
138lymph node development (GO:0048535)2.49330902
139positive regulation of alpha-beta T cell proliferation (GO:0046641)2.48864671
140regulation of B cell proliferation (GO:0030888)2.46637403
141positive regulation of antigen processing and presentation (GO:0002579)2.45778019
142regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.45643294
143myeloid dendritic cell differentiation (GO:0043011)2.45238228
144regulation of B cell activation (GO:0050864)2.44646747
145nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43501544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.52470890
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.71171080
3* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58285912
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84849115
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66644352
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27613778
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.07180278
8SCL_19346495_ChIP-Seq_HPC-7_Human3.05590093
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.05262255
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94474225
11MYC_22102868_ChIP-Seq_BL_Human2.72492199
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65863025
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63383390
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58045809
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52743012
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50591436
17MYB_26560356_Chip-Seq_TH2_Human2.50560244
18VDR_21846776_ChIP-Seq_THP-1_Human2.39096170
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.36687908
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36452791
21RUNX_20019798_ChIP-Seq_JUKART_Human2.36299908
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35978719
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30123948
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28412498
25* MAF_26560356_Chip-Seq_TH1_Human2.21591481
26MYB_26560356_Chip-Seq_TH1_Human2.20521444
27* SPI1_23547873_ChIP-Seq_NB4_Human2.18972911
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.13698588
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11058585
30GATA1_22025678_ChIP-Seq_K562_Human2.05950879
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.04271450
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99910346
33VDR_24763502_ChIP-Seq_THP-1_Human1.95131812
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.94633126
35UTX_26944678_Chip-Seq_JUKART_Human1.93703206
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89700551
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88616263
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.85612963
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85211421
40* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82483424
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80180816
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.69227170
43VDR_24787735_ChIP-Seq_THP-1_Human1.69188364
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66995902
45TCF7_22412390_ChIP-Seq_EML_Mouse1.65021618
46* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60546679
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55676730
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54152875
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53806686
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52362658
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51177832
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50699408
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50178456
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49956473
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48565658
56* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48473898
57GATA1_19941826_ChIP-Seq_K562_Human1.44494411
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43028450
59* GATA3_27048872_Chip-Seq_THYMUS_Human1.41842698
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40295797
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38087813
62CIITA_25753668_ChIP-Seq_RAJI_Human1.36552876
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35560633
64MAF_26560356_Chip-Seq_TH2_Human1.34360641
65PU_27001747_Chip-Seq_BMDM_Mouse1.33305398
66VDR_23849224_ChIP-Seq_CD4+_Human1.31624764
67* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31028647
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30983977
69* SPI1_23127762_ChIP-Seq_K562_Human1.27988537
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27257701
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26410108
72* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26075547
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24361864
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24116242
75GATA2_19941826_ChIP-Seq_K562_Human1.23848312
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23543232
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21805653
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20749695
79* FOXP3_21729870_ChIP-Seq_TREG_Human1.14991460
80ELK1_19687146_ChIP-ChIP_HELA_Human1.14235472
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11721664
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.08906389
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.03955923
84* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03678096
85* GATA3_26560356_Chip-Seq_TH2_Human1.02647466
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01219671
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00362322
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98914010
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98832520
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98324343
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98034922
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95586211
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.94694365
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.94586605
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93049047
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88624210
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87801217
98* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86233931
99KDM2B_26808549_Chip-Seq_DND41_Human0.84684863
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84393072
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83602666
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82805779
103EST1_17652178_ChIP-ChIP_JURKAT_Human0.81065850
104* GATA2_21666600_ChIP-Seq_HMVEC_Human0.79422724
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78624733
106TFEB_21752829_ChIP-Seq_HELA_Human0.77861828
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.77729962
108GABP_17652178_ChIP-ChIP_JURKAT_Human0.77450531
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77421833
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77264642
111NCOR1_26117541_ChIP-Seq_K562_Human0.76899126
112XRN2_22483619_ChIP-Seq_HELA_Human0.76341066
113GATA3_26560356_Chip-Seq_TH1_Human0.75551070
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75080383
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75067950
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74619860
117SMRT_27268052_Chip-Seq_Bcells_Human0.72031200
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71285713
119* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70752808
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69486763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77954019
2MP0003763_abnormal_thymus_physiology3.18281231
3MP0005671_abnormal_response_to3.15817643
4MP0001800_abnormal_humoral_immune2.95302263
5MP0002396_abnormal_hematopoietic_system2.94101186
6MP0000685_abnormal_immune_system2.85610097
7MP0002166_altered_tumor_susceptibility2.74222775
8MP0005387_immune_system_phenotype2.72812508
9MP0001790_abnormal_immune_system2.72812508
10* MP0002452_abnormal_antigen_presenting2.58544676
11MP0009785_altered_susceptibility_to2.55587543
12* MP0005000_abnormal_immune_tolerance2.54784919
13* MP0002420_abnormal_adaptive_immunity2.48678282
14* MP0002723_abnormal_immune_serum2.48163238
15* MP0001819_abnormal_immune_cell2.45485834
16* MP0002398_abnormal_bone_marrow2.41038520
17MP0003436_decreased_susceptibility_to2.40865190
18MP0005025_abnormal_response_to2.37354516
19MP0002148_abnormal_hypersensitivity_rea2.27254492
20MP0002006_tumorigenesis2.15674483
21MP0005464_abnormal_platelet_physiology2.14263949
22MP0002419_abnormal_innate_immunity2.13918411
23* MP0000716_abnormal_immune_system2.13047958
24MP0003300_gastrointestinal_ulcer2.11477775
25MP0001873_stomach_inflammation2.07499058
26MP0003724_increased_susceptibility_to2.06098431
27MP0010155_abnormal_intestine_physiology2.05756045
28MP0004808_abnormal_hematopoietic_stem2.04927228
29* MP0000689_abnormal_spleen_morphology1.98361524
30MP0002722_abnormal_immune_system1.96685522
31MP0002405_respiratory_system_inflammati1.96489779
32MP0001853_heart_inflammation1.94223890
33MP0003303_peritoneal_inflammation1.93720657
34MP0009333_abnormal_splenocyte_physiolog1.86315306
35MP0001545_abnormal_hematopoietic_system1.84817786
36MP0005397_hematopoietic_system_phenotyp1.84817786
37MP0000465_gastrointestinal_hemorrhage1.84068643
38MP0004947_skin_inflammation1.83648443
39* MP0002429_abnormal_blood_cell1.83153437
40MP0000703_abnormal_thymus_morphology1.80578705
41MP0001845_abnormal_inflammatory_respons1.64247134
42MP0003866_abnormal_defecation1.61743257
43MP0006054_spinal_hemorrhage1.60127149
44MP0005174_abnormal_tail_pigmentation1.58264806
45MP0000490_abnormal_crypts_of1.56888140
46MP0006082_CNS_inflammation1.48470827
47MP0009278_abnormal_bone_marrow1.43459567
48MP0008057_abnormal_DNA_replication1.41472576
49MP0003172_abnormal_lysosome_physiology1.37708092
50MP0010352_gastrointestinal_tract_polyps1.35709161
51MP0002933_joint_inflammation1.35214915
52MP0003656_abnormal_erythrocyte_physiolo1.34814080
53MP0005310_abnormal_salivary_gland1.33016007
54MP0003693_abnormal_embryo_hatching1.32705229
55MP0000858_altered_metastatic_potential1.29993813
56MP0002009_preneoplasia1.24000554
57MP0008007_abnormal_cellular_replicative1.20714218
58MP0010094_abnormal_chromosome_stability1.18155971
59MP0005075_abnormal_melanosome_morpholog1.16853250
60MP0008469_abnormal_protein_level1.16171495
61MP0002019_abnormal_tumor_incidence1.14778721
62MP0005451_abnormal_body_composition1.14690535
63MP0001533_abnormal_skeleton_physiology1.13396436
64MP0002095_abnormal_skin_pigmentation1.11701388
65MP0008004_abnormal_stomach_pH1.10221545
66MP0008260_abnormal_autophagy1.02100725
67MP0002877_abnormal_melanocyte_morpholog1.01833344
68MP0003077_abnormal_cell_cycle1.01751298
69MP0003448_altered_tumor_morphology1.00362627
70MP0001851_eye_inflammation0.98046774
71MP0002132_abnormal_respiratory_system0.95763228
72MP0005166_decreased_susceptibility_to0.93038536
73MP0010307_abnormal_tumor_latency0.88864478
74MP0004883_abnormal_blood_vessel0.88068797
75MP0003191_abnormal_cellular_cholesterol0.84923137
76MP0003045_fibrosis0.83276804
77MP0003183_abnormal_peptide_metabolism0.82337870
78MP0002138_abnormal_hepatobiliary_system0.81046691
79MP0004264_abnormal_extraembryonic_tissu0.80592216
80MP0003943_abnormal_hepatobiliary_system0.80312700
81MP0004381_abnormal_hair_follicle0.79606933
82MP0000015_abnormal_ear_pigmentation0.78983151
83MP0009764_decreased_sensitivity_to0.78965258
84MP0005023_abnormal_wound_healing0.78606343
85MP0003453_abnormal_keratinocyte_physiol0.77641450
86MP0003075_altered_response_to0.77090562
87MP0004957_abnormal_blastocyst_morpholog0.76695204
88MP0000604_amyloidosis0.76503087
89MP0003828_pulmonary_edema0.76470404
90MP0004510_myositis0.76386061
91MP0005164_abnormal_response_to0.75084927
92MP0002928_abnormal_bile_duct0.72692709
93MP0010234_abnormal_vibrissa_follicle0.72625978
94MP0003566_abnormal_cell_adhesion0.72401530
95MP0005076_abnormal_cell_differentiation0.72388091
96MP0005058_abnormal_lysosome_morphology0.72020227
97MP0000343_altered_response_to0.71838466
98MP0009765_abnormal_xenobiotic_induced0.71477149
99MP0009763_increased_sensitivity_to0.70168795
100MP0001216_abnormal_epidermal_layer0.69008164
101MP0002998_abnormal_bone_remodeling0.68908135
102MP0000569_abnormal_digit_pigmentation0.67973225
103MP0001663_abnormal_digestive_system0.67425754
104MP0005390_skeleton_phenotype0.65526028
105MP0001191_abnormal_skin_condition0.65435040
106MP0000477_abnormal_intestine_morphology0.64859433
107MP0000249_abnormal_blood_vessel0.64859245
108MP0003252_abnormal_bile_duct0.64169029
109MP0000313_abnormal_cell_death0.63663344
110MP0008058_abnormal_DNA_repair0.63383604
111MP0002136_abnormal_kidney_physiology0.63008736
112MP0003111_abnormal_nucleus_morphology0.62730879
113MP0002254_reproductive_system_inflammat0.62502406
114MP0009931_abnormal_skin_appearance0.62406972
115MP0002060_abnormal_skin_morphology0.61823911
116MP0009840_abnormal_foam_cell0.61348303
117MP0003795_abnormal_bone_structure0.60708997
118MP0003091_abnormal_cell_migration0.59236509
119MP0000609_abnormal_liver_physiology0.57361266
120MP0001765_abnormal_ion_homeostasis0.51728097
121MP0005381_digestive/alimentary_phenotyp0.49870499
122MP0004484_altered_response_of0.48880641
123MP0009115_abnormal_fat_cell0.48672602

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.58038840
2Chronic otitis media (HP:0000389)4.32796423
3Recurrent viral infections (HP:0004429)4.27811226
4Recurrent bronchitis (HP:0002837)4.25664184
5Elevated erythrocyte sedimentation rate (HP:0003565)4.14636579
6Agammaglobulinemia (HP:0004432)3.98489266
7Recurrent fungal infections (HP:0002841)3.91276478
8T lymphocytopenia (HP:0005403)3.87521567
9Thrombocytosis (HP:0001894)3.86859645
10Myositis (HP:0100614)3.86385255
11Abnormality of T cell number (HP:0011839)3.83344587
12Recurrent abscess formation (HP:0002722)3.79722898
13Panhypogammaglobulinemia (HP:0003139)3.73984420
14B lymphocytopenia (HP:0010976)3.72778969
15Abnormality of B cell number (HP:0010975)3.72778969
16Eczematoid dermatitis (HP:0000976)3.66016966
17Cellulitis (HP:0100658)3.63207559
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.58321589
19Abnormality of T cells (HP:0002843)3.57904846
20Meningitis (HP:0001287)3.54184040
21Thyroiditis (HP:0100646)3.52422504
22Recurrent bacterial skin infections (HP:0005406)3.51713046
23Petechiae (HP:0000967)3.45288141
24Abnormality of T cell physiology (HP:0011840)3.31411617
25Gastrointestinal infarctions (HP:0005244)3.20308202
26Abnormality of the fingertips (HP:0001211)3.19403293
27IgG deficiency (HP:0004315)3.18427479
28Lymphopenia (HP:0001888)3.12891958
29Severe combined immunodeficiency (HP:0004430)3.12800126
30Vasculitis (HP:0002633)3.10682859
31Inflammation of the large intestine (HP:0002037)3.09806994
32Gastrointestinal inflammation (HP:0004386)3.08381400
33Prolonged bleeding time (HP:0003010)3.08191650
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.04753543
35Spontaneous hematomas (HP:0007420)3.02776312
36Recurrent cutaneous fungal infections (HP:0011370)3.00090731
37Chronic mucocutaneous candidiasis (HP:0002728)3.00090731
38Nasal polyposis (HP:0100582)2.97302921
39Eosinophilia (HP:0001880)2.96361883
40Combined immunodeficiency (HP:0005387)2.87157603
41Pustule (HP:0200039)2.86641294
42Gastrointestinal stroma tumor (HP:0100723)2.81799584
43Granulocytopenia (HP:0001913)2.81088105
44Recurrent skin infections (HP:0001581)2.80494269
45Orchitis (HP:0100796)2.77296745
46Optic neuritis (HP:0100653)2.75837743
47Retrobulbar optic neuritis (HP:0100654)2.75837743
48Abnormality of eosinophils (HP:0001879)2.73985687
49Autoimmune thrombocytopenia (HP:0001973)2.71931547
50Recurrent gram-negative bacterial infections (HP:0005420)2.71637959
51Reticulocytopenia (HP:0001896)2.71571109
52Hypoplasia of the thymus (HP:0000778)2.71518706
53Abnormality of the nasal mucosa (HP:0000433)2.71125550
54Increased IgM level (HP:0003496)2.69773656
55Leukocytosis (HP:0001974)2.67352556
56Abnormality of cells of the erythroid lineage (HP:0012130)2.67072381
57Colitis (HP:0002583)2.67029857
58Papilloma (HP:0012740)2.64037483
59Verrucae (HP:0200043)2.64037483
60Epistaxis (HP:0000421)2.63825575
61Abnormal number of erythroid precursors (HP:0012131)2.62734606
62Chronic diarrhea (HP:0002028)2.62451030
63IgA deficiency (HP:0002720)2.60455597
64Mediastinal lymphadenopathy (HP:0100721)2.60092508
65Autoimmune hemolytic anemia (HP:0001890)2.58735925
66Abnormality of the prostate (HP:0008775)2.57409425
67Interstitial pulmonary disease (HP:0006530)2.56608725
68Abnormal platelet function (HP:0011869)2.56216324
69Impaired platelet aggregation (HP:0003540)2.56216324
70Lymphoma (HP:0002665)2.55501108
71Increased IgE level (HP:0003212)2.53031682
72Urticaria (HP:0001025)2.50432833
73Encephalitis (HP:0002383)2.49086847
74Osteomyelitis (HP:0002754)2.49029815
75Obstructive lung disease (HP:0006536)2.46782692
76Chronic obstructive pulmonary disease (HP:0006510)2.46782692
77Gingivitis (HP:0000230)2.46753464
78Recurrent sinusitis (HP:0011108)2.46538311
79Pulmonary embolism (HP:0002204)2.44382578
80Acute myeloid leukemia (HP:0004808)2.42982133
81Bronchitis (HP:0012387)2.41382491
82Chronic sinusitis (HP:0011109)2.40522916
83Abnormal platelet volume (HP:0011876)2.40249695
84Gangrene (HP:0100758)2.39964755
85Gingival bleeding (HP:0000225)2.37266640
86Periodontitis (HP:0000704)2.36210354
87Arterial thrombosis (HP:0004420)2.31839187
88Pulmonary infiltrates (HP:0002113)2.31540810
89Viral hepatitis (HP:0006562)2.29356725
90Joint swelling (HP:0001386)2.28580681
91Sepsis (HP:0100806)2.24565835
92Fatigue (HP:0012378)2.24290381
93Keratoconjunctivitis sicca (HP:0001097)2.19898802
94Hemoptysis (HP:0002105)2.19819747
95Abnormality of macrophages (HP:0004311)2.19693906
96Stomatitis (HP:0010280)2.18546669
97Aplastic anemia (HP:0001915)2.17333044
98Amaurosis fugax (HP:0100576)2.15958100
99Skin ulcer (HP:0200042)2.15884854
100Acute lymphatic leukemia (HP:0006721)2.15141088
101Recurrent pneumonia (HP:0006532)2.14899750
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14394963
103Increased mean platelet volume (HP:0011877)2.11466984
104Polyneuropathy (HP:0001271)2.09937312
105Menorrhagia (HP:0000132)2.08960358
106Emphysema (HP:0002097)2.06779165
107Hypergammaglobulinemia (HP:0010702)2.05465062
108Chest pain (HP:0100749)2.05304051
109Recurrent lower respiratory tract infections (HP:0002783)2.03565861
110Abnormality of the pleura (HP:0002103)2.03089445
111Acute hepatic failure (HP:0006554)2.02892397
112Keratoconjunctivitis (HP:0001096)2.02635712
113Prostate neoplasm (HP:0100787)2.00455528
114Purpura (HP:0000979)1.95866320
115Hypoproteinemia (HP:0003075)1.95444932
116Hypochromic anemia (HP:0001931)1.95357785
117Anorexia (HP:0002039)1.95122460
118Neoplasm of the tracheobronchial system (HP:0100552)1.94996320
119Neutropenia (HP:0001875)1.94637321
120Poikiloderma (HP:0001029)1.94504960
121Skin rash (HP:0000988)1.93225949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34029414
2TXK3.05045466
3MAP3K142.36653250
4TYK22.33543812
5TEC2.30830735
6JAK32.29598846
7BTK2.28430791
8EEF2K2.27518899
9KIT2.24095362
10STK102.19916673
11MAP3K102.15741397
12PRPF4B2.14758920
13IRAK42.13284848
14BMPR22.11849687
15IKBKE2.06468135
16ZAP702.05514088
17ITK1.99056828
18TBK11.94125778
19MST41.75776575
20BLK1.72863325
21SYK1.67357061
22TAOK31.65914822
23CSF1R1.56164089
24IKBKB1.55597463
25TAOK21.55276467
26GRK61.53236050
27LRRK21.45123217
28TAOK11.42608584
29PIM11.41840566
30LCK1.40911306
31FGFR31.39717750
32FGFR41.38872836
33JAK11.38044716
34TGFBR21.35189342
35FLT31.32826090
36PIM21.31821264
37NLK1.31180113
38ERN11.28453539
39MAP2K31.27891374
40MKNK21.27268648
41RPS6KA41.27180021
42RPS6KB21.26935988
43IRAK11.26460331
44NME21.25697474
45MAP3K111.20561267
46MAP3K11.20156778
47IRAK31.18621121
48CSK1.18563119
49CLK11.14023677
50HCK1.14000519
51STK41.09927509
52LYN1.08822344
53CHUK1.07998340
54TGFBR11.07278614
55TRPM70.98965534
56EPHB10.97418405
57NUAK10.91980546
58FRK0.87772750
59TESK20.86426892
60HIPK20.84285315
61KDR0.81831276
62SCYL20.80887944
63IRAK20.79737251
64FES0.77966548
65FGR0.76592180
66NEK20.74702198
67CDK40.74312958
68CDK60.72414119
69STK160.72058754
70PASK0.71792277
71VRK10.71272415
72BRSK20.70916468
73MATK0.70627283
74PKN20.69923171
75PDK10.69793939
76ACVR1B0.66756585
77JAK20.66692902
78MAP3K130.66105538
79PRKCQ0.65877649
80TNK20.64926029
81MAP3K30.63063871
82RIPK40.62133737
83CDK90.60184783
84NEK90.60010632
85MAP3K50.58727005
86MAPK40.57933410
87DYRK30.57840973
88MARK30.57090494
89MKNK10.56421946
90MAP3K20.56257576
91CDK120.56136507
92MAPK70.54289739
93EPHA30.53255917
94PRKG20.53133685
95PIK3CA0.53016262
96MAPK110.52834473
97ATR0.52549392
98MAP2K20.52467092
99RPS6KA50.52425754
100CAMKK20.52172776
101MAPK120.51839113
102PIK3CG0.51358761
103CDC70.50348961
104TLK10.48604389
105EIF2AK30.48013417
106MAPKAPK20.47865666
107MAP3K80.47786796
108RPS6KA60.47460153
109TRIB30.47172366
110MAPKAPK30.46673210
111NEK60.43553133
112PDPK10.42844193
113PTK60.42191943
114AURKB0.40194907
115RET0.38482238
116MAPKAPK50.38118745
117EIF2AK10.36921011
118TSSK60.36218748
119RPS6KC10.36065489
120RPS6KL10.36065489
121STK240.35765339
122ABL10.35582544
123MAP3K70.34357062
124BRD40.34193244
125SIK30.33347976
126MAPK30.32352162
127FYN0.32144189
128YES10.31944967
129KSR20.31901922
130IGF1R0.26518478
131GRK70.25343696
132RAF10.24694843

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.06490351
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.54618129
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.53564638
4B cell receptor signaling pathway_Homo sapiens_hsa046622.45855654
5Leishmaniasis_Homo sapiens_hsa051402.37132415
6Measles_Homo sapiens_hsa051622.31183067
7Antigen processing and presentation_Homo sapiens_hsa046122.30682763
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22492885
9Ribosome_Homo sapiens_hsa030102.21192919
10Hematopoietic cell lineage_Homo sapiens_hsa046402.18437723
11DNA replication_Homo sapiens_hsa030302.14636626
12Osteoclast differentiation_Homo sapiens_hsa043801.94330235
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90253008
14T cell receptor signaling pathway_Homo sapiens_hsa046601.87500889
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86320107
16Allograft rejection_Homo sapiens_hsa053301.84279112
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81240737
18Herpes simplex infection_Homo sapiens_hsa051681.78868620
19Mismatch repair_Homo sapiens_hsa034301.68330738
20Non-homologous end-joining_Homo sapiens_hsa034501.66078074
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.64771782
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54256621
23Graft-versus-host disease_Homo sapiens_hsa053321.51447897
24Base excision repair_Homo sapiens_hsa034101.51029494
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49516669
26Toxoplasmosis_Homo sapiens_hsa051451.45928366
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.32583560
28Influenza A_Homo sapiens_hsa051641.31653027
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28713130
30Apoptosis_Homo sapiens_hsa042101.27261476
31Legionellosis_Homo sapiens_hsa051341.26222855
32Hepatitis B_Homo sapiens_hsa051611.24607685
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.23763073
34Acute myeloid leukemia_Homo sapiens_hsa052211.23361673
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20732829
36Platelet activation_Homo sapiens_hsa046111.19239210
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18084260
38Shigellosis_Homo sapiens_hsa051311.18082996
39Pertussis_Homo sapiens_hsa051331.16258802
40Autoimmune thyroid disease_Homo sapiens_hsa053201.15805510
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15127655
42Rheumatoid arthritis_Homo sapiens_hsa053231.14626280
43Homologous recombination_Homo sapiens_hsa034401.14309502
44TNF signaling pathway_Homo sapiens_hsa046681.10877185
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10581907
46Chemokine signaling pathway_Homo sapiens_hsa040621.09739792
47Viral myocarditis_Homo sapiens_hsa054161.09126793
48Malaria_Homo sapiens_hsa051441.06788111
49Caffeine metabolism_Homo sapiens_hsa002321.04334354
50p53 signaling pathway_Homo sapiens_hsa041151.02342601
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00822994
52Viral carcinogenesis_Homo sapiens_hsa052030.99793065
53Asthma_Homo sapiens_hsa053100.99679517
54Small cell lung cancer_Homo sapiens_hsa052220.97427876
55Epstein-Barr virus infection_Homo sapiens_hsa051690.96636337
56Spliceosome_Homo sapiens_hsa030400.95820224
57Tuberculosis_Homo sapiens_hsa051520.95700871
58Other glycan degradation_Homo sapiens_hsa005110.95583738
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92429419
60Staphylococcus aureus infection_Homo sapiens_hsa051500.89451366
61Hepatitis C_Homo sapiens_hsa051600.87135237
62HTLV-I infection_Homo sapiens_hsa051660.86734739
63Cell cycle_Homo sapiens_hsa041100.86209951
64Fanconi anemia pathway_Homo sapiens_hsa034600.85093520
65Nucleotide excision repair_Homo sapiens_hsa034200.84773468
66Pancreatic cancer_Homo sapiens_hsa052120.82335360
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80565023
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79419354
69Systemic lupus erythematosus_Homo sapiens_hsa053220.75849605
70Salmonella infection_Homo sapiens_hsa051320.75152078
71VEGF signaling pathway_Homo sapiens_hsa043700.73649924
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72408040
73Protein export_Homo sapiens_hsa030600.71588966
74Phagosome_Homo sapiens_hsa041450.70120436
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.70015128
76RNA degradation_Homo sapiens_hsa030180.69354556
77Renal cell carcinoma_Homo sapiens_hsa052110.69205678
78Dorso-ventral axis formation_Homo sapiens_hsa043200.64725943
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.62545344
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61331374
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60957479
82Inositol phosphate metabolism_Homo sapiens_hsa005620.60147635
83African trypanosomiasis_Homo sapiens_hsa051430.59574454
84Pyrimidine metabolism_Homo sapiens_hsa002400.58854934
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58464817
86mTOR signaling pathway_Homo sapiens_hsa041500.56913467
87Choline metabolism in cancer_Homo sapiens_hsa052310.55341573
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.54802087
89Non-small cell lung cancer_Homo sapiens_hsa052230.54287468
90Insulin resistance_Homo sapiens_hsa049310.53972794
91Amoebiasis_Homo sapiens_hsa051460.53259038
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53184382
93N-Glycan biosynthesis_Homo sapiens_hsa005100.53062809
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52532369
95Endometrial cancer_Homo sapiens_hsa052130.52472658
96Prolactin signaling pathway_Homo sapiens_hsa049170.51702010
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46143466
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45806670
99MicroRNAs in cancer_Homo sapiens_hsa052060.45245451
100Thyroid cancer_Homo sapiens_hsa052160.45014552
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44656334
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.43251674
103Renin-angiotensin system_Homo sapiens_hsa046140.41437894
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41399935
105Endocytosis_Homo sapiens_hsa041440.41175166
106HIF-1 signaling pathway_Homo sapiens_hsa040660.39810143
107FoxO signaling pathway_Homo sapiens_hsa040680.38904273
108One carbon pool by folate_Homo sapiens_hsa006700.38193675
109Pentose phosphate pathway_Homo sapiens_hsa000300.38043859
110Colorectal cancer_Homo sapiens_hsa052100.37694214
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.37375653
112MAPK signaling pathway_Homo sapiens_hsa040100.34582107
113Type I diabetes mellitus_Homo sapiens_hsa049400.34456495
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34392886
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34034013
116Lysosome_Homo sapiens_hsa041420.33814526
117ABC transporters_Homo sapiens_hsa020100.33712944
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33282439
119Notch signaling pathway_Homo sapiens_hsa043300.32918110
120Prostate cancer_Homo sapiens_hsa052150.32483618
121RNA polymerase_Homo sapiens_hsa030200.31326611
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29862688
123GnRH signaling pathway_Homo sapiens_hsa049120.29815672
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29674932
125Pathways in cancer_Homo sapiens_hsa052000.29490699
126RNA transport_Homo sapiens_hsa030130.29274873
127Glioma_Homo sapiens_hsa052140.27544264
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26714415
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.26580877
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25664990
131ErbB signaling pathway_Homo sapiens_hsa040120.23955295

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