ELF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.65915280
2mitotic sister chromatid cohesion (GO:0007064)4.64151017
3nuclear pore complex assembly (GO:0051292)4.27519887
4microglial cell activation (GO:0001774)4.16941747
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.11329414
6establishment of protein localization to Golgi (GO:0072600)4.04476704
7monoubiquitinated protein deubiquitination (GO:0035520)3.96207084
8peptidyl-lysine trimethylation (GO:0018023)3.92509854
9cellular extravasation (GO:0045123)3.92310007
10regulation of B cell receptor signaling pathway (GO:0050855)3.92201851
11neutrophil mediated immunity (GO:0002446)3.91721037
12histone H3-K4 trimethylation (GO:0080182)3.80969592
13nuclear pore organization (GO:0006999)3.78685526
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.63212954
15regulation of translation, ncRNA-mediated (GO:0045974)3.63212954
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63212954
17positive regulation of granulocyte differentiation (GO:0030854)3.63075879
18protein targeting to Golgi (GO:0000042)3.58947251
19regulation of histone H3-K9 methylation (GO:0051570)3.56066893
20regulation of RNA export from nucleus (GO:0046831)3.53685154
21regulation of gamma-delta T cell differentiation (GO:0045586)3.50979980
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.50932804
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47366469
24positive regulation of gamma-delta T cell activation (GO:0046645)3.47063719
25positive regulation of histone deacetylation (GO:0031065)3.46238107
26histone H3-K9 methylation (GO:0051567)3.44700779
27protein K11-linked deubiquitination (GO:0035871)3.44652037
28behavioral response to nicotine (GO:0035095)3.42709164
29cellular response to ethanol (GO:0071361)3.28901854
30histone H3-K9 modification (GO:0061647)3.27149887
31myeloid leukocyte mediated immunity (GO:0002444)3.25271727
32pore complex assembly (GO:0046931)3.24783928
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22439614
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22439614
35cytoplasmic mRNA processing body assembly (GO:0033962)3.21946190
36rRNA catabolic process (GO:0016075)3.20873082
37regulation of gamma-delta T cell activation (GO:0046643)3.18604914
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14514483
39peptidyl-lysine methylation (GO:0018022)3.13550276
40translesion synthesis (GO:0019985)3.13521684
41mitotic chromosome condensation (GO:0007076)3.11916778
42RNA stabilization (GO:0043489)3.11518735
43mRNA stabilization (GO:0048255)3.11518735
44regulation of nucleobase-containing compound transport (GO:0032239)3.10568693
45adaptation of signaling pathway (GO:0023058)3.08602439
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08419359
47negative regulation of histone methylation (GO:0031061)3.07376117
48B cell receptor signaling pathway (GO:0050853)3.05498381
49positive regulation of developmental pigmentation (GO:0048087)3.03096893
50protein K48-linked deubiquitination (GO:0071108)3.02707847
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00551930
52chromatin assembly (GO:0031497)3.00133218
53protein K63-linked deubiquitination (GO:0070536)2.96480558
54embryonic hemopoiesis (GO:0035162)2.93676252
55positive thymic T cell selection (GO:0045059)2.91661245
56regulation of DNA endoreduplication (GO:0032875)2.89906790
57coronary vasculature morphogenesis (GO:0060977)2.87407927
58peptidyl-lysine dimethylation (GO:0018027)2.86838174
59dosage compensation (GO:0007549)2.85234238
60chromosome condensation (GO:0030261)2.85205319
61tachykinin receptor signaling pathway (GO:0007217)2.84298047
62negative regulation of neurotransmitter transport (GO:0051589)2.84163506
63cell wall macromolecule catabolic process (GO:0016998)2.83887834
64fucose catabolic process (GO:0019317)2.83721153
65L-fucose metabolic process (GO:0042354)2.83721153
66L-fucose catabolic process (GO:0042355)2.83721153
67antigen processing and presentation of endogenous antigen (GO:0019883)2.82110380
68histone H3-K9 demethylation (GO:0033169)2.80436450
69macrophage activation involved in immune response (GO:0002281)2.80190105
70acrosome assembly (GO:0001675)2.79711915
71positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.78665186
72regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.78665186
73nucleus localization (GO:0051647)2.78277381
74activated T cell proliferation (GO:0050798)2.77166348
75macrophage activation (GO:0042116)2.76389189
76regulation of pigment cell differentiation (GO:0050932)2.73206683
77detection of molecule of bacterial origin (GO:0032490)2.72291405
78regulation of MHC class II biosynthetic process (GO:0045346)2.72274371
79gene silencing by RNA (GO:0031047)2.71605651
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69533490
81cellular hyperosmotic response (GO:0071474)2.66406109
82germ cell migration (GO:0008354)2.65738494
83genitalia morphogenesis (GO:0035112)2.64886996
84cilium or flagellum-dependent cell motility (GO:0001539)2.61582150
85fusion of sperm to egg plasma membrane (GO:0007342)2.60337297
86negative regulation of granulocyte differentiation (GO:0030853)2.59765611
87DNA packaging (GO:0006323)2.59316994
88positive regulation of mast cell activation (GO:0033005)2.59293699
89histone lysine methylation (GO:0034968)2.57762170
90protein localization to Golgi apparatus (GO:0034067)2.57257449
91cerebellar Purkinje cell differentiation (GO:0021702)2.57228551
92protein localization to chromosome, centromeric region (GO:0071459)2.56713547
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56510633
94DNA unwinding involved in DNA replication (GO:0006268)2.56111598
95positive regulation of protein deacetylation (GO:0090312)2.55830594
96histone H3-K4 methylation (GO:0051568)2.55200564
97regulation of mRNA stability (GO:0043488)2.55024326
98regulation of germinal center formation (GO:0002634)2.53498349
99endothelial tube morphogenesis (GO:0061154)2.52790875
100morphogenesis of an endothelium (GO:0003159)2.52790875
101histone H3-K36 demethylation (GO:0070544)2.51885484
102definitive hemopoiesis (GO:0060216)2.50916733
103negative thymic T cell selection (GO:0045060)2.50273803
104heterochromatin organization (GO:0070828)2.49785675
105prenylation (GO:0097354)2.48772915
106protein prenylation (GO:0018342)2.48772915
1073-UTR-mediated mRNA stabilization (GO:0070935)2.48638954
108NLS-bearing protein import into nucleus (GO:0006607)2.48571583
109neutrophil activation (GO:0042119)2.47511437
110negative T cell selection (GO:0043383)2.47276479
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45803898
112positive regulation by organism of defense response of other organism involved in symbiotic interact2.45803898
113modulation by symbiont of host immune response (GO:0052553)2.45803898
114positive regulation by symbiont of host defense response (GO:0052509)2.45803898
115modulation by symbiont of host defense response (GO:0052031)2.45803898
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45803898
117gene silencing (GO:0016458)2.44637751
118regulation of memory T cell differentiation (GO:0043380)2.43450885
119mitotic nuclear envelope disassembly (GO:0007077)2.43296552
120negative regulation of cAMP-mediated signaling (GO:0043951)2.43084088
121regulation of establishment of cell polarity (GO:2000114)2.42841487
122centriole replication (GO:0007099)2.42576205
123response to pheromone (GO:0019236)2.42540180
124protein-DNA complex disassembly (GO:0032986)2.40982643
125nucleosome disassembly (GO:0006337)2.40982643
126neutrophil activation involved in immune response (GO:0002283)2.40760081
127intraciliary transport (GO:0042073)2.40738134
128sister chromatid segregation (GO:0000819)2.40207444
129regulation of RNA stability (GO:0043487)2.40120312
130negative regulation of RNA splicing (GO:0033119)2.40010724
131interleukin-6-mediated signaling pathway (GO:0070102)2.39672455
132regulation of interleukin-12 biosynthetic process (GO:0045075)2.38256171
133microtubule anchoring (GO:0034453)2.37218775
134DNA duplex unwinding (GO:0032508)2.35796844
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.35467197
136negative regulation of cell killing (GO:0031342)2.35467197
137DNA geometric change (GO:0032392)2.34979207
138natural killer cell differentiation (GO:0001779)2.34544591
139cAMP catabolic process (GO:0006198)2.34428163
140negative regulation of B cell proliferation (GO:0030889)2.34365610
141regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.33442282
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.32913771
143cellular response to interleukin-15 (GO:0071350)2.32674653
144DNA demethylation (GO:0080111)2.32459856
145positive regulation of mitotic sister chromatid separation (GO:1901970)2.30618618
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.30618618
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.30618618
148regulation of histone methylation (GO:0031060)2.28857033
149regulation of mRNA catabolic process (GO:0061013)2.28308864
150regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.27699584
151positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.27699584
152sister chromatid cohesion (GO:0007062)2.27514408
153growth hormone receptor signaling pathway (GO:0060396)2.27401511
154protein localization to kinetochore (GO:0034501)2.27067780
155membrane disassembly (GO:0030397)2.25810174
156nuclear envelope disassembly (GO:0051081)2.25810174
157histone mRNA catabolic process (GO:0071044)2.25063698
158regulation of sister chromatid cohesion (GO:0007063)2.24576534
159negative regulation of DNA repair (GO:0045738)2.24546781
160pre-miRNA processing (GO:0031054)2.23809018
161DNA conformation change (GO:0071103)2.23614912
162regulation of centriole replication (GO:0046599)2.22816996
163positive T cell selection (GO:0043368)2.21815766
164chromatin assembly or disassembly (GO:0006333)2.21305451
165histone demethylation (GO:0016577)2.20371494
166hepatocyte apoptotic process (GO:0097284)2.19880547
167regulation of histone H3-K27 methylation (GO:0061085)2.19868755
168DNA replication-dependent nucleosome organization (GO:0034723)2.19802183
169DNA replication-dependent nucleosome assembly (GO:0006335)2.19802183
170histone lysine demethylation (GO:0070076)2.19666207
171negative regulation of histone modification (GO:0031057)2.18660295
172oocyte development (GO:0048599)2.18028868
173positive regulation of mRNA catabolic process (GO:0061014)2.17951713
174negative regulation of mRNA metabolic process (GO:1903312)2.17935927
175positive regulation of B cell differentiation (GO:0045579)2.16094795
176interkinetic nuclear migration (GO:0022027)2.16077823
177cellular response to osmotic stress (GO:0071470)2.14354137
178response to UV-C (GO:0010225)2.12138675
179sperm-egg recognition (GO:0035036)2.12030326
180negative regulation of gene expression, epigenetic (GO:0045814)2.11365784
181antigen processing and presentation via MHC class Ib (GO:0002475)2.11150104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68164408
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67904795
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.64411835
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58754276
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51236756
6MYC_22102868_ChIP-Seq_BL_Human3.14627776
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05931928
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90548474
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87783468
10GBX2_23144817_ChIP-Seq_PC3_Human2.81405254
11* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75799403
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75764548
13* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62950992
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49264347
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.31923518
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.30994774
17IGF1R_20145208_ChIP-Seq_DFB_Human2.30360479
18ZNF274_21170338_ChIP-Seq_K562_Hela2.21815052
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19188523
20FUS_26573619_Chip-Seq_HEK293_Human2.18702055
21VDR_22108803_ChIP-Seq_LS180_Human2.16020492
22VDR_21846776_ChIP-Seq_THP-1_Human2.12559679
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11696887
24TAF15_26573619_Chip-Seq_HEK293_Human2.08143270
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06945514
26SCL_19346495_ChIP-Seq_HPC-7_Human2.06886557
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02412035
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02112750
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01744299
30MAF_26560356_Chip-Seq_TH1_Human2.01533896
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01192169
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95771676
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95123342
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93341461
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.90243083
36ER_23166858_ChIP-Seq_MCF-7_Human1.90133875
37UTX_26944678_Chip-Seq_JUKART_Human1.88635311
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85606380
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83718838
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83306296
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81776067
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.81294860
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81220156
44MYB_26560356_Chip-Seq_TH1_Human1.78458575
45MYB_26560356_Chip-Seq_TH2_Human1.77997952
46EWS_26573619_Chip-Seq_HEK293_Human1.76743589
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.76692092
48P300_19829295_ChIP-Seq_ESCs_Human1.75666698
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69223590
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67990855
51STAT3_23295773_ChIP-Seq_U87_Human1.65785020
52KDM2B_26808549_Chip-Seq_DND41_Human1.65672564
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.62554657
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62472956
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59782364
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59645617
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.57912691
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56923426
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56567263
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.56225443
61VDR_24763502_ChIP-Seq_THP-1_Human1.56099335
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55712384
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55363426
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.52060614
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51900012
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51846325
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50771623
68AR_21909140_ChIP-Seq_LNCAP_Human1.50288818
69TCF4_23295773_ChIP-Seq_U87_Human1.49010383
70TP53_16413492_ChIP-PET_HCT116_Human1.47945366
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47751266
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46656418
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46656418
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44405523
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43063751
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42152524
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41837555
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40709990
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.40702883
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40527335
81GATA1_22025678_ChIP-Seq_K562_Human1.39649635
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39023727
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38165888
84CLOCK_20551151_ChIP-Seq_293T_Human1.38041418
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.37309417
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36516730
87CBP_20019798_ChIP-Seq_JUKART_Human1.36516730
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.35333355
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35121582
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33705996
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33182927
92RUNX_20019798_ChIP-Seq_JUKART_Human1.32763603
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.31812220
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31221275
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30192074
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29708369
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27988154
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.27972393
99SPI1_23127762_ChIP-Seq_K562_Human1.27337562
100NCOR1_26117541_ChIP-Seq_K562_Human1.27168520
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26800588
102CIITA_25753668_ChIP-Seq_RAJI_Human1.26781814
103BCAT_22108803_ChIP-Seq_LS180_Human1.26637312
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.26341755
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.24014034
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.23094536
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22571838
108* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22107479
109AR_25329375_ChIP-Seq_VCAP_Human1.19477388
110* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18194711
111PU_27001747_Chip-Seq_BMDM_Mouse1.17942633
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17180332
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.16806229
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16546771
115AR_21572438_ChIP-Seq_LNCaP_Human1.16362382
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.15375864
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14727963
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14678125
119* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14292492
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13818200
121* GATA3_26560356_Chip-Seq_TH2_Human1.13698493
122P53_22387025_ChIP-Seq_ESCs_Mouse1.12923929
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12634093
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12213655
125FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11955644
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.11675338
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11674183
128GATA3_27048872_Chip-Seq_THYMUS_Human1.11422591
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10209759
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.09688562
131ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09513067
132VDR_24787735_ChIP-Seq_THP-1_Human1.09007736
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08456427
134TBX20_22328084_ChIP-Seq_HEART_Mouse1.08381989
135TBX20_22080862_ChIP-Seq_HEART_Mouse1.08381989
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08319818
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08016236
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07571291
139SPI1_23547873_ChIP-Seq_NB4_Human1.07334501
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.06553164
141CMYC_18555785_Chip-Seq_ESCs_Mouse1.06254632
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05720344
143FOXO3_23340844_ChIP-Seq_DLD1_Human1.05609089
144* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04964011
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04025554
146NOTCH1_21737748_ChIP-Seq_TLL_Human1.03712406
147RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03305054
148VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03185851
149EZH2_22144423_ChIP-Seq_EOC_Human1.02742317
150STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02660591
151* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02541218
152MAF_26560356_Chip-Seq_TH2_Human1.02514713
153TCF4_22108803_ChIP-Seq_LS180_Human1.02038977
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01741991
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00912447
156AHR_22903824_ChIP-Seq_MCF-7_Human1.00427413
157TP63_17297297_ChIP-ChIP_HaCaT_Human1.00229169
158SMRT_27268052_Chip-Seq_Bcells_Human0.99457038
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99432570
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98683054
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98026201
162UBF1/2_26484160_Chip-Seq_HMECs_Human0.96494100
163SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96189629
164TP63_19390658_ChIP-ChIP_HaCaT_Human0.95078424
165FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94889970
166FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94272083
167IRF8_21731497_ChIP-ChIP_J774_Mouse0.93579253
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93262289
169EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92992829
170SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92421705
171SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92421705
172* BRD4_25478319_ChIP-Seq_HGPS_Human0.91377167
173PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90709806
174RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90354697
175CHD1_26751641_Chip-Seq_LNCaP_Human0.89783037
176ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89570042
177GATA6_25053715_ChIP-Seq_YYC3_Human0.88491360
178P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88344673
179GATA2_21666600_ChIP-Seq_HMVEC_Human0.84147351
180ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83688714
181GATA1_19941826_ChIP-Seq_K562_Human0.83657770
182SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79111678
183SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78677602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.84249877
2MP0000569_abnormal_digit_pigmentation2.95386196
3MP0003724_increased_susceptibility_to2.87278615
4MP0003646_muscle_fatigue2.60807986
5MP0003300_gastrointestinal_ulcer2.44171110
6MP0004808_abnormal_hematopoietic_stem2.38377604
7MP0002396_abnormal_hematopoietic_system2.23147437
8MP0010352_gastrointestinal_tract_polyps2.20951053
9MP0006054_spinal_hemorrhage2.13955621
10MP0002877_abnormal_melanocyte_morpholog2.13071028
11MP0003705_abnormal_hypodermis_morpholog2.09598522
12MP0009278_abnormal_bone_marrow2.02834308
13MP0005076_abnormal_cell_differentiation1.88666457
14MP0003566_abnormal_cell_adhesion1.85701387
15MP0003656_abnormal_erythrocyte_physiolo1.85168466
16MP0002166_altered_tumor_susceptibility1.82764931
17MP0010094_abnormal_chromosome_stability1.81705964
18MP0002638_abnormal_pupillary_reflex1.80724946
19MP0004145_abnormal_muscle_electrophysio1.79653962
20MP0000371_diluted_coat_color1.73611960
21MP0003195_calcinosis1.70697269
22MP0005075_abnormal_melanosome_morpholog1.67259262
23MP0003121_genomic_imprinting1.65414749
24MP0010307_abnormal_tumor_latency1.64409813
25MP0005408_hypopigmentation1.60671971
26MP0004043_abnormal_pH_regulation1.54840213
27MP0000015_abnormal_ear_pigmentation1.51210541
28MP0002102_abnormal_ear_morphology1.50636781
29MP0000733_abnormal_muscle_development1.48038033
30MP0004142_abnormal_muscle_tone1.46001206
31MP0003077_abnormal_cell_cycle1.45052961
32MP0008057_abnormal_DNA_replication1.43862702
33MP0003890_abnormal_embryonic-extraembry1.43399911
34MP0008995_early_reproductive_senescence1.43258499
35MP0003763_abnormal_thymus_physiology1.41548198
36MP0005410_abnormal_fertilization1.40948912
37MP0000685_abnormal_immune_system1.38513065
38MP0003303_peritoneal_inflammation1.38340202
39MP0003111_abnormal_nucleus_morphology1.37348089
40MP0004272_abnormal_basement_membrane1.36479270
41MP0000427_abnormal_hair_cycle1.35093925
42MP0000372_irregular_coat_pigmentation1.33901531
43MP0002928_abnormal_bile_duct1.33411457
44MP0004084_abnormal_cardiac_muscle1.32926590
45MP0002837_dystrophic_cardiac_calcinosis1.31675205
46MP0004484_altered_response_of1.31673731
47MP0003828_pulmonary_edema1.30871971
48MP0004197_abnormal_fetal_growth/weight/1.30383419
49MP0001545_abnormal_hematopoietic_system1.29495263
50MP0005397_hematopoietic_system_phenotyp1.29495263
51MP0002332_abnormal_exercise_endurance1.29219723
52MP0000703_abnormal_thymus_morphology1.28040824
53MP0001879_abnormal_lymphatic_vessel1.27362776
54MP0005266_abnormal_metabolism1.22170846
55MP0010368_abnormal_lymphatic_system1.20963056
56MP0001915_intracranial_hemorrhage1.20416011
57MP0003221_abnormal_cardiomyocyte_apopto1.20261806
58MP0002006_tumorigenesis1.20234713
59MP0008007_abnormal_cellular_replicative1.20151127
60MP0005671_abnormal_response_to1.19225882
61MP0004147_increased_porphyrin_level1.19086283
62MP0008438_abnormal_cutaneous_collagen1.18288975
63MP0002398_abnormal_bone_marrow1.18055353
64MP0002277_abnormal_respiratory_mucosa1.17134756
65MP0008961_abnormal_basal_metabolism1.16518187
66MP0003567_abnormal_fetal_cardiomyocyte1.16104886
67MP0000465_gastrointestinal_hemorrhage1.15737967
68MP0002009_preneoplasia1.14345372
69MP0005023_abnormal_wound_healing1.13966343
70MP0004130_abnormal_muscle_cell1.13714980
71MP0002086_abnormal_extraembryonic_tissu1.13652583
72MP0009764_decreased_sensitivity_to1.13574215
73MP0004883_abnormal_blood_vessel1.13558020
74MP0010630_abnormal_cardiac_muscle1.13370181
75MP0001800_abnormal_humoral_immune1.11996985
76MP0002419_abnormal_innate_immunity1.11882161
77MP0005174_abnormal_tail_pigmentation1.11269266
78MP0008877_abnormal_DNA_methylation1.08963630
79MP0002088_abnormal_embryonic_growth/wei1.08421259
80MP0003984_embryonic_growth_retardation1.05946179
81MP0010678_abnormal_skin_adnexa1.05329815
82MP0005253_abnormal_eye_physiology1.04639279
83MP0005000_abnormal_immune_tolerance1.03172237
84MP0005310_abnormal_salivary_gland1.01800952
85MP0002132_abnormal_respiratory_system1.01647891
86MP0003448_altered_tumor_morphology1.01086313
87MP0006082_CNS_inflammation1.00807255
88MP0002138_abnormal_hepatobiliary_system0.99269094
89MP0001730_embryonic_growth_arrest0.99082441
90MP0002925_abnormal_cardiovascular_devel0.98792918
91MP0002722_abnormal_immune_system0.98707671
92MP0002452_abnormal_antigen_presenting0.98203989
93MP0005551_abnormal_eye_electrophysiolog0.97674798
94MP0005380_embryogenesis_phenotype0.97330123
95MP0001672_abnormal_embryogenesis/_devel0.97330123
96MP0002095_abnormal_skin_pigmentation0.96477895
97MP0004185_abnormal_adipocyte_glucose0.95991237
98MP0000767_abnormal_smooth_muscle0.95932671
99MP0006072_abnormal_retinal_apoptosis0.95708006
100MP0004381_abnormal_hair_follicle0.95110676
101MP0003252_abnormal_bile_duct0.94406917
102MP0005623_abnormal_meninges_morphology0.94164739
103MP0000689_abnormal_spleen_morphology0.94055892
104MP0006276_abnormal_autonomic_nervous0.93964835
105MP0000350_abnormal_cell_proliferation0.93866177
106MP0001835_abnormal_antigen_presentation0.92156499
107MP0002075_abnormal_coat/hair_pigmentati0.91630381
108MP0001790_abnormal_immune_system0.91456834
109MP0005387_immune_system_phenotype0.91456834
110MP0002420_abnormal_adaptive_immunity0.90700428
111MP0004947_skin_inflammation0.90469151
112MP0003436_decreased_susceptibility_to0.90275079
113MP0001501_abnormal_sleep_pattern0.89599851
114MP0001697_abnormal_embryo_size0.89262075
115MP0005025_abnormal_response_to0.89203627
116MP0001819_abnormal_immune_cell0.88605405
117MP0000716_abnormal_immune_system0.88319718
118MP0001929_abnormal_gametogenesis0.88261050
119MP0000490_abnormal_crypts_of0.86334030
120MP0003091_abnormal_cell_migration0.86096747
121MP0002084_abnormal_developmental_patter0.85708033
122MP0002019_abnormal_tumor_incidence0.85601582
123MP0002405_respiratory_system_inflammati0.85150746
124MP0005666_abnormal_adipose_tissue0.85040427
125MP0009046_muscle_twitch0.84903415
126MP0000383_abnormal_hair_follicle0.84809546
127MP0004036_abnormal_muscle_relaxation0.84433217
128MP0003279_aneurysm0.83981301
129MP0002168_other_aberrant_phenotype0.83843721
130MP0002128_abnormal_blood_circulation0.83800816
131MP0009703_decreased_birth_body0.83266235
132MP0002429_abnormal_blood_cell0.83147367
133MP0003045_fibrosis0.83021604
134MP0002092_abnormal_eye_morphology0.82615527
135MP0008058_abnormal_DNA_repair0.82327141
136MP0004215_abnormal_myocardial_fiber0.81496104
137MP0004957_abnormal_blastocyst_morpholog0.81474270
138MP0005257_abnormal_intraocular_pressure0.80679346
139MP0000266_abnormal_heart_morphology0.80582457
140MP0005645_abnormal_hypothalamus_physiol0.79326567
141MP0003693_abnormal_embryo_hatching0.78429603
142MP0010155_abnormal_intestine_physiology0.78051556
143MP0002723_abnormal_immune_serum0.77983782
144MP0003453_abnormal_keratinocyte_physiol0.77016065
145MP0000858_altered_metastatic_potential0.76489085
146MP0005464_abnormal_platelet_physiology0.76451661
147MP0005375_adipose_tissue_phenotype0.76374311
148MP0003943_abnormal_hepatobiliary_system0.76349853
149MP0001486_abnormal_startle_reflex0.74740981
150MP0009785_altered_susceptibility_to0.74136968
151MP0005220_abnormal_exocrine_pancreas0.73984791
152MP0005386_behavior/neurological_phenoty0.73498259
153MP0004924_abnormal_behavior0.73498259
154MP0000631_abnormal_neuroendocrine_gland0.72198815
155MP0005376_homeostasis/metabolism_phenot0.70934020
156MP0004885_abnormal_endolymph0.69431860
157MP0001986_abnormal_taste_sensitivity0.68675266
158MP0005167_abnormal_blood-brain_barrier0.67286318
159MP0001851_eye_inflammation0.67218429

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)3.58345590
2Genetic anticipation (HP:0003743)3.50810034
3Abnormality of the fingertips (HP:0001211)3.45991650
4Pancreatic cysts (HP:0001737)3.37767641
5Cerebral aneurysm (HP:0004944)3.28927728
6Pancreatic fibrosis (HP:0100732)3.27875507
7Hyperventilation (HP:0002883)3.20614043
8Abnormality of the renal cortex (HP:0011035)3.16963480
9Fair hair (HP:0002286)3.11012656
10Subacute progressive viral hepatitis (HP:0006572)3.08489359
11Papillary thyroid carcinoma (HP:0002895)2.98468192
12Nasal polyposis (HP:0100582)2.98218017
13Short 4th metacarpal (HP:0010044)2.92289728
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92289728
15Chronic hepatic failure (HP:0100626)2.88604056
16Abnormality of the nasal mucosa (HP:0000433)2.88437119
17Aortic aneurysm (HP:0004942)2.87981231
18Abnormality of the renal medulla (HP:0100957)2.87959764
19Nephronophthisis (HP:0000090)2.81247907
20Stomatitis (HP:0010280)2.77226585
21Volvulus (HP:0002580)2.74149684
22Hematochezia (HP:0002573)2.72519926
23Widely spaced teeth (HP:0000687)2.71505279
24Protruding tongue (HP:0010808)2.70743526
25High pitched voice (HP:0001620)2.68046065
26True hermaphroditism (HP:0010459)2.65430084
27Gaze-evoked nystagmus (HP:0000640)2.61721393
28Thyroiditis (HP:0100646)2.60982745
29Abnormality of midbrain morphology (HP:0002418)2.54210122
30Molar tooth sign on MRI (HP:0002419)2.54210122
31Neoplasm of the tracheobronchial system (HP:0100552)2.51039529
32Hyperacusis (HP:0010780)2.50211420
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.47900581
34Bicuspid aortic valve (HP:0001647)2.44927213
35Recurrent cutaneous fungal infections (HP:0011370)2.44115034
36Chronic mucocutaneous candidiasis (HP:0002728)2.44115034
37Acute lymphatic leukemia (HP:0006721)2.41607713
38Recurrent bacterial skin infections (HP:0005406)2.37884981
39Absent frontal sinuses (HP:0002688)2.37042737
40Progressive cerebellar ataxia (HP:0002073)2.36343423
41Generalized hypopigmentation of hair (HP:0011358)2.34255929
42Retrobulbar optic neuritis (HP:0100654)2.33454420
43Optic neuritis (HP:0100653)2.33454420
44Heterotopia (HP:0002282)2.32613177
45Recurrent bronchitis (HP:0002837)2.28475532
46Rectal prolapse (HP:0002035)2.26711539
47Medial flaring of the eyebrow (HP:0010747)2.24299424
48Abnormality of the 4th metacarpal (HP:0010012)2.22095680
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21780148
50Renovascular hypertension (HP:0100817)2.19976469
51Congenital stationary night blindness (HP:0007642)2.19477139
52Viral hepatitis (HP:0006562)2.19406375
53Mitral valve prolapse (HP:0001634)2.18820570
54Febrile seizures (HP:0002373)2.17332253
55Increased nuchal translucency (HP:0010880)2.14784685
56Thyroid carcinoma (HP:0002890)2.11778099
57Hypoplastic iliac wings (HP:0002866)2.11314582
58Spontaneous hematomas (HP:0007420)2.10938317
59Abnormal rod and cone electroretinograms (HP:0008323)2.10822006
60Narrow palate (HP:0000189)2.10135639
61Recurrent viral infections (HP:0004429)2.09964232
62Abnormal biliary tract physiology (HP:0012439)2.09885233
63Bile duct proliferation (HP:0001408)2.09885233
64Osteolytic defects of the hand bones (HP:0009699)2.09553447
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.09553447
66Neoplasm of the adrenal cortex (HP:0100641)2.09421758
67Hypochromic microcytic anemia (HP:0004840)2.08250721
68Acute myeloid leukemia (HP:0004808)2.06342976
69Recurrent abscess formation (HP:0002722)2.05801820
70Broad-based gait (HP:0002136)2.05345173
71Macroorchidism (HP:0000053)2.04823479
72Keratoconjunctivitis (HP:0001096)2.04799169
73Cellulitis (HP:0100658)2.02335636
74Aneurysm (HP:0002617)2.01213748
75Trigonocephaly (HP:0000243)2.01209669
76Long eyelashes (HP:0000527)2.00842152
77Subaortic stenosis (HP:0001682)1.97625609
78Abnormality of the left ventricular outflow tract (HP:0011103)1.97625609
79Attenuation of retinal blood vessels (HP:0007843)1.97264706
80Recurrent skin infections (HP:0001581)1.96225687
81Prominent nose (HP:0000448)1.94914028
82Cystic liver disease (HP:0006706)1.92529787
83Aqueductal stenosis (HP:0002410)1.92412160
84Colitis (HP:0002583)1.92406372
85Poor coordination (HP:0002370)1.92284162
86Renal cortical cysts (HP:0000803)1.92276589
87Micronodular cirrhosis (HP:0001413)1.91770222
88Neonatal hypoglycemia (HP:0001998)1.90279116
89Truncal obesity (HP:0001956)1.89411078
90Myositis (HP:0100614)1.89003147
91Abnormality of eosinophils (HP:0001879)1.88949736
92Increased density of long bones (HP:0006392)1.88916438
93Autoimmune hemolytic anemia (HP:0001890)1.88350162
94Gastrointestinal carcinoma (HP:0002672)1.87421307
95Malignant gastrointestinal tract tumors (HP:0006749)1.87421307
96Congenital primary aphakia (HP:0007707)1.86712607
97Shallow orbits (HP:0000586)1.86485037
98Abolished electroretinogram (ERG) (HP:0000550)1.86473172
99Abnormal hair whorl (HP:0010721)1.85246691
100Persistence of primary teeth (HP:0006335)1.85222105
101Orchitis (HP:0100796)1.85036196
102Alveolar cell carcinoma (HP:0006519)1.84887516
103Abnormal pancreas size (HP:0012094)1.84142680
104Bronchitis (HP:0012387)1.84083159
105Leukocytosis (HP:0001974)1.83734225
106Genital tract atresia (HP:0001827)1.83569682
107Abnormality of T cells (HP:0002843)1.83383761
108Elfin facies (HP:0004428)1.82381331
109Eosinophilia (HP:0001880)1.82309323
110Abnormality of B cell number (HP:0010975)1.81979806
111Cutaneous melanoma (HP:0012056)1.81272388
112Chronic diarrhea (HP:0002028)1.80827437
113Diastasis recti (HP:0001540)1.79479509
114T lymphocytopenia (HP:0005403)1.79226706
115Proximal placement of thumb (HP:0009623)1.79161598
116Deviation of the thumb (HP:0009603)1.79119444
117Cutis marmorata (HP:0000965)1.78351001
118Keratoconjunctivitis sicca (HP:0001097)1.78056870
119Gait imbalance (HP:0002141)1.77792779
120Tubular atrophy (HP:0000092)1.77101586
121Bowel diverticulosis (HP:0005222)1.76821164
122Intestinal atresia (HP:0011100)1.76676104
123Tubulointerstitial nephritis (HP:0001970)1.75006650
124Drooling (HP:0002307)1.74970501
125Ulnar bowing (HP:0003031)1.74851056
126Dislocated radial head (HP:0003083)1.74465807
127Aortic dissection (HP:0002647)1.74451428
128Albinism (HP:0001022)1.73935434
129Excessive salivation (HP:0003781)1.73606186
130Absent speech (HP:0001344)1.73583610
131Hip dysplasia (HP:0001385)1.73378839
132Nephrogenic diabetes insipidus (HP:0009806)1.72135033
133Biliary tract neoplasm (HP:0100574)1.72105813
134Hyperkalemia (HP:0002153)1.71965600
135Broad palm (HP:0001169)1.71671872
136Supernumerary ribs (HP:0005815)1.71600974
137Large for gestational age (HP:0001520)1.71422693
138Vaginal atresia (HP:0000148)1.71281467
139Cupped ear (HP:0000378)1.71158379
140Increased connective tissue (HP:0009025)1.70735875
141Bladder diverticulum (HP:0000015)1.69960856
142Gastrointestinal inflammation (HP:0004386)1.69108699
143Deep philtrum (HP:0002002)1.68651104
144Inflammation of the large intestine (HP:0002037)1.68522873
145Low anterior hairline (HP:0000294)1.67002800
146Conjunctival telangiectasia (HP:0000524)1.66978040
147Protrusio acetabuli (HP:0003179)1.66792796
148Colon cancer (HP:0003003)1.66654295
149Hypopigmentation of the fundus (HP:0007894)1.66016661
150Ankle contracture (HP:0006466)1.65951301
151Recurrent fungal infections (HP:0002841)1.65543292
152Spinal cord lesions (HP:0100561)1.65465676
153Syringomyelia (HP:0003396)1.65465676
154Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65377144
155Selective tooth agenesis (HP:0001592)1.65233776
156Verrucae (HP:0200043)1.64786407
157Papilloma (HP:0012740)1.64786407
158Constricted visual fields (HP:0001133)1.64770480
159Broad metatarsal (HP:0001783)1.64533900
160Abnormality of T cell physiology (HP:0011840)1.64130308
161Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63606559
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63137532
163Furrowed tongue (HP:0000221)1.62943236
164Enlarged penis (HP:0000040)1.62585238
165Congenital hepatic fibrosis (HP:0002612)1.62132905
166Abnormality of T cell number (HP:0011839)1.62023268
167Limited elbow extension (HP:0001377)1.61979986
168Abnormality of incisor morphology (HP:0011063)1.61614567
169Sandal gap (HP:0001852)1.61438874
170Gastrointestinal infarctions (HP:0005244)1.60659589
171Postaxial foot polydactyly (HP:0001830)1.60456258
172Skull defect (HP:0001362)1.60219376
173Eczematoid dermatitis (HP:0000976)1.59928127
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.59578653
175Abnormality of the radial head (HP:0003995)1.59535298
176Spondylolisthesis (HP:0003302)1.59287775
177Overriding aorta (HP:0002623)1.59274982
178Chronic otitis media (HP:0000389)1.59167932
179Vertebral arch anomaly (HP:0008438)1.57726599
180Abnormality of the thoracic spine (HP:0100711)1.57577581
181Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57279236
182Disproportionate tall stature (HP:0001519)1.57091479
183Dilatation of the ascending aorta (HP:0005111)1.55393757
184Renal duplication (HP:0000075)1.55342638
185Flat cornea (HP:0007720)1.54670873
186Thrombocytosis (HP:0001894)1.54100969
187Neoplasm of the oral cavity (HP:0100649)1.52900522
188Periodontitis (HP:0000704)1.52330327
189Pseudobulbar signs (HP:0002200)1.51865079
190Abnormality of the peritoneum (HP:0002585)1.51674291
191Abnormal platelet volume (HP:0011876)1.51459574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.21005713
2PKN23.29547056
3EEF2K3.01612147
4PASK2.97729266
5CDK192.87360949
6TRIB32.73055407
7CDK122.63146499
8CDC72.33976942
9ACVR1B2.23938935
10PIK3CG2.19555594
11AKT32.17834009
12BMPR1B2.09419670
13TTN1.97837754
14TGFBR21.88833038
15STK101.81364188
16NEK21.75456087
17MKNK21.72730470
18PTK61.72636107
19OBSCN1.71391944
20IRAK41.69059270
21SGK21.68980508
22MAP4K11.68752118
23TLK11.61792086
24MAP3K41.58247446
25STK41.56537462
26MAP4K21.49534692
27TXK1.48266682
28RIPK41.44981008
29STK31.43651146
30LATS11.38962441
31FLT31.36587406
32MAP2K31.34703648
33CASK1.33344137
34PDK41.32074776
35PDK31.32074776
36CDK41.30817127
37CDK61.29903929
38RIPK11.28946068
39FGFR31.27731846
40ERBB31.27296551
41CAMK1D1.23604248
42WNK31.20731861
43RPS6KA41.19777542
44MARK31.17412780
45BLK1.15465823
46MAPK131.11355126
47LRRK21.09993358
48TYK21.07241243
49SYK1.06947325
50FGFR41.04076007
51TNIK1.02114769
52CDK91.01420822
53MAP3K140.99437382
54IKBKE0.99367717
55CAMKK20.98381442
56MKNK10.97804278
57PIM10.97706385
58PTK2B0.96499897
59YES10.96296231
60WNK10.96132509
61MTOR0.96046086
62FES0.95601569
63JAK30.94737638
64ICK0.94294273
65RPS6KB20.93279762
66BRD40.92956789
67TGFBR10.92701095
68EPHA30.92285882
69CAMK1G0.91224186
70PDGFRA0.90758889
71SIK10.90625405
72SGK2230.90446084
73SGK4940.90446084
74SGK30.90157539
75CLK10.89630504
76MAP2K40.88636941
77PAK40.88478594
78PIK3CA0.88268155
79DYRK30.85753155
80DYRK1B0.85240741
81NEK90.84027435
82PINK10.83885381
83DMPK0.83508426
84JAK10.82937299
85FGR0.82065053
86PAK30.81746541
87EPHB10.81566116
88TESK10.81257128
89STK38L0.78828033
90ZAP700.78273179
91CAMK40.78200754
92LYN0.76600146
93ERN10.76545723
94CSF1R0.76518779
95OXSR10.76486458
96PDGFRB0.76454913
97BMPR20.76401096
98ITK0.75771063
99STK110.75713264
100MAP3K70.75084647
101ATR0.74040993
102ZAK0.73548484
103BTK0.73311068
104PAK20.73092836
105TEC0.72929398
106MAP3K20.71899863
107CHUK0.66788851
108IKBKB0.66675212
109SGK10.65517576
110TRPM70.65444836
111TAF10.64935811
112BMX0.64649229
113CSK0.63609279
114GRK10.63097932
115PRKCQ0.62808884
116NTRK30.62609353
117NLK0.60967821
118IRAK20.60318702
119TNK20.60283938
120TBK10.59919585
121KIT0.59785418
122TAOK30.59637509
123ADRBK20.58447250
124DYRK1A0.58398877
125MELK0.57796465
126SCYL20.57108523
127HIPK20.56825363
128PLK20.56608497
129MAP3K60.55380640
130TIE10.55247980
131WEE10.54975889
132MST1R0.54641882
133FGFR20.54523815
134FGFR10.53642421
135GRK60.53433987
136MAP3K80.53210394
137HCK0.52457066
138DAPK20.51259426
139ATM0.51009748
140TTK0.50927239
141CAMKK10.50646277
142PDK20.50257721
143CCNB10.50248870
144PRKAA10.49975283
145NUAK10.49943616
146STK390.49404906
147AURKB0.48785653
148CHEK10.48379837
149BRSK20.47278621
150RPS6KA50.46573564
151KSR10.46094209
152JAK20.45552130
153CDK70.45026992
154ADRBK10.44626121
155IRAK10.44547659
156EIF2AK30.43823067
157MARK20.43603535
158FRK0.43042411
159MET0.41657172
160MAPK110.41237161
161KDR0.39125675
162PRKAA20.38682727
163LCK0.36742026

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.25450436
2Circadian rhythm_Homo sapiens_hsa047101.98835380
3Regulation of autophagy_Homo sapiens_hsa041401.98447676
4Lysine degradation_Homo sapiens_hsa003101.98262134
5Small cell lung cancer_Homo sapiens_hsa052221.91020856
6Nitrogen metabolism_Homo sapiens_hsa009101.87127399
7Chronic myeloid leukemia_Homo sapiens_hsa052201.83566669
8Antigen processing and presentation_Homo sapiens_hsa046121.74661323
9B cell receptor signaling pathway_Homo sapiens_hsa046621.73241693
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64506102
11MicroRNAs in cancer_Homo sapiens_hsa052061.62378849
12Graft-versus-host disease_Homo sapiens_hsa053321.58870375
13Osteoclast differentiation_Homo sapiens_hsa043801.55472217
14Primary immunodeficiency_Homo sapiens_hsa053401.55139930
15Cell cycle_Homo sapiens_hsa041101.54675348
16Viral carcinogenesis_Homo sapiens_hsa052031.50368492
17Toxoplasmosis_Homo sapiens_hsa051451.47037665
18Adherens junction_Homo sapiens_hsa045201.44216440
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.43698186
20Dorso-ventral axis formation_Homo sapiens_hsa043201.43112163
21Measles_Homo sapiens_hsa051621.39630364
22Herpes simplex infection_Homo sapiens_hsa051681.38261581
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36854171
24Viral myocarditis_Homo sapiens_hsa054161.36783355
25Asthma_Homo sapiens_hsa053101.32818724
26Notch signaling pathway_Homo sapiens_hsa043301.32216299
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32059308
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30902837
29HTLV-I infection_Homo sapiens_hsa051661.30517128
30Pancreatic cancer_Homo sapiens_hsa052121.30303393
31Leishmaniasis_Homo sapiens_hsa051401.30033693
32DNA replication_Homo sapiens_hsa030301.28662425
33mRNA surveillance pathway_Homo sapiens_hsa030151.28311545
34Allograft rejection_Homo sapiens_hsa053301.27935646
35Acute myeloid leukemia_Homo sapiens_hsa052211.26853146
36Focal adhesion_Homo sapiens_hsa045101.26660587
37Renin-angiotensin system_Homo sapiens_hsa046141.23735043
38Tuberculosis_Homo sapiens_hsa051521.23554699
39Autoimmune thyroid disease_Homo sapiens_hsa053201.22997669
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22916535
41Staphylococcus aureus infection_Homo sapiens_hsa051501.20354627
42Type I diabetes mellitus_Homo sapiens_hsa049401.20171136
43ECM-receptor interaction_Homo sapiens_hsa045121.19455946
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19254054
45T cell receptor signaling pathway_Homo sapiens_hsa046601.17630522
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17586881
47Phototransduction_Homo sapiens_hsa047441.17047117
48Insulin resistance_Homo sapiens_hsa049311.16771031
49Type II diabetes mellitus_Homo sapiens_hsa049301.14131631
50Colorectal cancer_Homo sapiens_hsa052101.13818075
51Hepatitis B_Homo sapiens_hsa051611.13478443
52Proteoglycans in cancer_Homo sapiens_hsa052051.13145229
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12568442
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12547335
55Platelet activation_Homo sapiens_hsa046111.12314972
56Ether lipid metabolism_Homo sapiens_hsa005651.10997830
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10243718
58Mismatch repair_Homo sapiens_hsa034301.05592211
59Prostate cancer_Homo sapiens_hsa052151.05468192
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04667724
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04026802
62p53 signaling pathway_Homo sapiens_hsa041151.02317847
63mTOR signaling pathway_Homo sapiens_hsa041501.01532269
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01491914
65FoxO signaling pathway_Homo sapiens_hsa040680.99897399
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99058278
67Non-small cell lung cancer_Homo sapiens_hsa052230.97714805
68Taste transduction_Homo sapiens_hsa047420.97265359
69RNA transport_Homo sapiens_hsa030130.96658866
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.96482410
71Non-homologous end-joining_Homo sapiens_hsa034500.96360638
72Influenza A_Homo sapiens_hsa051640.95518222
73ABC transporters_Homo sapiens_hsa020100.94562642
74Hematopoietic cell lineage_Homo sapiens_hsa046400.93725543
75Apoptosis_Homo sapiens_hsa042100.92123167
76Base excision repair_Homo sapiens_hsa034100.91078487
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.90507822
78TNF signaling pathway_Homo sapiens_hsa046680.89987534
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89041537
80Spliceosome_Homo sapiens_hsa030400.88942327
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88213893
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.87991620
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87974459
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86683587
85Endometrial cancer_Homo sapiens_hsa052130.85875589
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85737399
87Prolactin signaling pathway_Homo sapiens_hsa049170.85631616
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84648914
89Fanconi anemia pathway_Homo sapiens_hsa034600.84574608
90Selenocompound metabolism_Homo sapiens_hsa004500.83910821
91Legionellosis_Homo sapiens_hsa051340.83735832
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82629650
93Linoleic acid metabolism_Homo sapiens_hsa005910.82098537
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.81153389
95Basal transcription factors_Homo sapiens_hsa030220.80041393
96Long-term depression_Homo sapiens_hsa047300.79083689
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.78367414
98Olfactory transduction_Homo sapiens_hsa047400.77677641
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77553728
100Pathways in cancer_Homo sapiens_hsa052000.75801909
101AMPK signaling pathway_Homo sapiens_hsa041520.75749044
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75563906
103Alcoholism_Homo sapiens_hsa050340.75109427
104VEGF signaling pathway_Homo sapiens_hsa043700.75074549
105Nicotine addiction_Homo sapiens_hsa050330.74414644
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74326486
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.73596261
108Glucagon signaling pathway_Homo sapiens_hsa049220.73061183
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72261387
110Amoebiasis_Homo sapiens_hsa051460.71782796
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71058062
112Renal cell carcinoma_Homo sapiens_hsa052110.70273409
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70151023
114Calcium signaling pathway_Homo sapiens_hsa040200.69999412
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68894027
116Malaria_Homo sapiens_hsa051440.68559703
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67944421
118Oxytocin signaling pathway_Homo sapiens_hsa049210.67138209
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66831946
120HIF-1 signaling pathway_Homo sapiens_hsa040660.66798520
121One carbon pool by folate_Homo sapiens_hsa006700.64543239
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64383998
123Choline metabolism in cancer_Homo sapiens_hsa052310.64163522
124Epstein-Barr virus infection_Homo sapiens_hsa051690.64092626
125Renin secretion_Homo sapiens_hsa049240.61980520
126MAPK signaling pathway_Homo sapiens_hsa040100.60438585
127Homologous recombination_Homo sapiens_hsa034400.60122856
128Dilated cardiomyopathy_Homo sapiens_hsa054140.60092095
129RNA degradation_Homo sapiens_hsa030180.60021689
130Cholinergic synapse_Homo sapiens_hsa047250.60017025
131Inositol phosphate metabolism_Homo sapiens_hsa005620.59996045
132Morphine addiction_Homo sapiens_hsa050320.59969167
133Serotonergic synapse_Homo sapiens_hsa047260.59780521
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.59754714
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59049540
136TGF-beta signaling pathway_Homo sapiens_hsa043500.58772714
137Chemokine signaling pathway_Homo sapiens_hsa040620.57198506
138Circadian entrainment_Homo sapiens_hsa047130.56239248
139cAMP signaling pathway_Homo sapiens_hsa040240.56106018
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55931672
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55783662
142Glutamatergic synapse_Homo sapiens_hsa047240.54408622
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53695512
144ErbB signaling pathway_Homo sapiens_hsa040120.53282848
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52698935

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