ELF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.25940456
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.73023927
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73023927
4antigen processing and presentation of endogenous antigen (GO:0019883)4.45487198
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36695872
6interferon-gamma production (GO:0032609)4.35517213
7detection of other organism (GO:0098543)4.21258421
8negative regulation of erythrocyte differentiation (GO:0045647)4.17970323
9regulation of gamma-delta T cell differentiation (GO:0045586)4.16320481
10detection of bacterium (GO:0016045)4.00332575
11negative regulation of cell killing (GO:0031342)3.95712796
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95712796
13regulation of gamma-delta T cell activation (GO:0046643)3.94427046
14regulation of B cell receptor signaling pathway (GO:0050855)3.90728676
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88256967
16leukocyte aggregation (GO:0070486)3.80407492
17positive thymic T cell selection (GO:0045059)3.73680867
18negative T cell selection (GO:0043383)3.63275900
19negative thymic T cell selection (GO:0045060)3.58609304
20detection of external biotic stimulus (GO:0098581)3.54717524
21T cell migration (GO:0072678)3.53229676
22regulation of B cell differentiation (GO:0045577)3.51874028
23negative regulation of phagocytosis (GO:0050765)3.50965695
24detection of molecule of bacterial origin (GO:0032490)3.48521821
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.46118929
26positive regulation of B cell differentiation (GO:0045579)3.44106883
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.42922497
28germinal center formation (GO:0002467)3.42663828
29response to host immune response (GO:0052572)3.40811244
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40811244
31B cell receptor signaling pathway (GO:0050853)3.39918403
32response to host (GO:0075136)3.36364539
33response to host defenses (GO:0052200)3.36364539
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36364539
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34952053
36tolerance induction (GO:0002507)3.31647785
37regulation of mast cell degranulation (GO:0043304)3.30022927
38immunoglobulin mediated immune response (GO:0016064)3.27860666
39thymic T cell selection (GO:0045061)3.23959289
40negative regulation of T cell mediated immunity (GO:0002710)3.19705922
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16315164
42regulation of leukocyte degranulation (GO:0043300)3.16242186
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14822660
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.14822660
45modulation by symbiont of host immune response (GO:0052553)3.14822660
46positive regulation by symbiont of host defense response (GO:0052509)3.14822660
47modulation by symbiont of host defense response (GO:0052031)3.14822660
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14822660
49T cell selection (GO:0045058)3.14394861
50detection of biotic stimulus (GO:0009595)3.14377084
51positive regulation of isotype switching (GO:0045830)3.13818046
52response to interleukin-15 (GO:0070672)3.12046300
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.11681767
54natural killer cell differentiation (GO:0001779)3.08044923
55positive T cell selection (GO:0043368)3.06914365
56response to muramyl dipeptide (GO:0032495)3.03804674
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02423515
58cellular extravasation (GO:0045123)3.00368572
59positive regulation of histone deacetylation (GO:0031065)2.99997989
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97759766
61regulation of mast cell activation involved in immune response (GO:0033006)2.97084671
62regulation of T-helper 2 cell differentiation (GO:0045628)2.95794272
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95617284
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95229801
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95061080
66macrophage activation (GO:0042116)2.94769415
67regulation of interferon-beta biosynthetic process (GO:0045357)2.93651411
68defense response to protozoan (GO:0042832)2.92442548
69negative regulation of leukocyte mediated immunity (GO:0002704)2.92294943
70NIK/NF-kappaB signaling (GO:0038061)2.90696486
71regulation of tolerance induction (GO:0002643)2.89240011
72leukocyte cell-cell adhesion (GO:0007159)2.88823740
73negative regulation of interleukin-12 production (GO:0032695)2.85778109
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84735547
75antigen processing and presentation via MHC class Ib (GO:0002475)2.82194675
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80754085
77neutrophil activation (GO:0042119)2.80567559
78positive regulation of interleukin-2 production (GO:0032743)2.79454868
79positive regulation of Cdc42 GTPase activity (GO:0043089)2.78780070
80hepatocyte apoptotic process (GO:0097284)2.78127119
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77892748
82neutrophil activation involved in immune response (GO:0002283)2.76645736
83negative regulation of cytokine production involved in immune response (GO:0002719)2.75985026
84T-helper 1 type immune response (GO:0042088)2.72536596
85positive regulation of protein deacetylation (GO:0090312)2.72515412
86response to laminar fluid shear stress (GO:0034616)2.72269019
87T cell costimulation (GO:0031295)2.71389674
88regulation of alpha-beta T cell proliferation (GO:0046640)2.70702747
89response to peptidoglycan (GO:0032494)2.70633414
90antigen receptor-mediated signaling pathway (GO:0050851)2.70121955
91positive regulation of mast cell activation (GO:0033005)2.69426777
92myeloid dendritic cell activation (GO:0001773)2.68690512
93B cell mediated immunity (GO:0019724)2.68110206
94regulation of T cell tolerance induction (GO:0002664)2.68019628
95T cell homeostasis (GO:0043029)2.67449235
96granulocyte activation (GO:0036230)2.66952959
97positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66841367
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.66557869
99microglial cell activation (GO:0001774)2.66502244
100interferon-gamma-mediated signaling pathway (GO:0060333)2.66499139
101neutrophil mediated immunity (GO:0002446)2.66286277
102lymphocyte costimulation (GO:0031294)2.65923313
103megakaryocyte development (GO:0035855)2.65498822
104regulation of mast cell activation (GO:0033003)2.64890508
105positive regulation of type 2 immune response (GO:0002830)2.64359014
106production of molecular mediator involved in inflammatory response (GO:0002532)2.64232988
107positive regulation of interferon-alpha production (GO:0032727)2.64178499
108cellular response to interleukin-15 (GO:0071350)2.63390703
109negative regulation of interleukin-6 production (GO:0032715)2.60726181
110positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59010571
111lymphocyte homeostasis (GO:0002260)2.58638246
112pinocytosis (GO:0006907)2.58527701
113negative regulation of B cell proliferation (GO:0030889)2.58480860
114regulation of interferon-alpha production (GO:0032647)2.58297078
115response to type I interferon (GO:0034340)2.57948866
116* natural killer cell activation (GO:0030101)2.57264117
117B cell homeostasis (GO:0001782)2.56878799
118regulation of antigen processing and presentation (GO:0002577)2.56530349
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55768182
120leukocyte degranulation (GO:0043299)2.55128764
121T cell receptor signaling pathway (GO:0050852)2.54914245
122negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54678795
123positive regulation of DNA recombination (GO:0045911)2.53514837
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52484767
125response to protozoan (GO:0001562)2.52071237
126regulation of T cell receptor signaling pathway (GO:0050856)2.51612298
127respiratory burst (GO:0045730)2.51509423
128type I interferon signaling pathway (GO:0060337)2.51198871
129cellular response to type I interferon (GO:0071357)2.51198871
130regulation of necroptotic process (GO:0060544)2.49798674
131establishment of endothelial barrier (GO:0061028)2.49350939
132regulation of response to interferon-gamma (GO:0060330)2.48714132
133definitive hemopoiesis (GO:0060216)2.48126598
134macrophage activation involved in immune response (GO:0002281)2.47840103
135mast cell activation (GO:0045576)2.46732435
136positive regulation of immunoglobulin mediated immune response (GO:0002891)2.45861823
137positive regulation of B cell mediated immunity (GO:0002714)2.45861823
138regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.43598500
139cellular response to zinc ion (GO:0071294)2.43499496
140myeloid dendritic cell differentiation (GO:0043011)2.42514537
141myeloid cell activation involved in immune response (GO:0002275)2.41912372
142protein localization to kinetochore (GO:0034501)2.37566585
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36933151
144positive regulation of cytokine biosynthetic process (GO:0042108)2.36098434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25363022
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.13799635
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.03602866
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97175808
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.82549080
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79953140
7MYC_22102868_ChIP-Seq_BL_Human3.34321546
8* IRF8_21731497_ChIP-ChIP_J774_Mouse3.12372294
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02581339
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84164611
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74416570
12VDR_21846776_ChIP-Seq_THP-1_Human2.60079552
13SCL_19346495_ChIP-Seq_HPC-7_Human2.58797996
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54345055
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.51793479
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51272497
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51111655
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48791995
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.46111148
20MYB_26560356_Chip-Seq_TH2_Human2.40333511
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38397987
22MAF_26560356_Chip-Seq_TH1_Human2.35328051
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34813676
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27944508
25RUNX_20019798_ChIP-Seq_JUKART_Human2.21871903
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.18998598
27MYB_26560356_Chip-Seq_TH1_Human2.16890234
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13492932
29* SPI1_23547873_ChIP-Seq_NB4_Human2.07519120
30UTX_26944678_Chip-Seq_JUKART_Human2.07158053
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03854793
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03366705
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03060212
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96509191
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.92665921
36* VDR_24763502_ChIP-Seq_THP-1_Human1.88128642
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79754180
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75912828
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73289152
40SPI1_23127762_ChIP-Seq_K562_Human1.69345032
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68950100
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66440480
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65102339
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63895082
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58913282
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.56789695
47KDM2B_26808549_Chip-Seq_DND41_Human1.54146924
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52989816
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48953903
50MAF_26560356_Chip-Seq_TH2_Human1.45013859
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.40885843
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.39615050
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38761010
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.37581755
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37399357
56RACK7_27058665_Chip-Seq_MCF-7_Human1.36712304
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36553198
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36510438
59* GATA1_19941826_ChIP-Seq_K562_Human1.35125427
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33207591
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32342162
62* VDR_24787735_ChIP-Seq_THP-1_Human1.32304591
63* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28533024
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.28213071
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27350973
66CIITA_25753668_ChIP-Seq_RAJI_Human1.26853458
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24043037
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23943311
69PU_27001747_Chip-Seq_BMDM_Mouse1.23363290
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19879850
71NCOR1_26117541_ChIP-Seq_K562_Human1.19263759
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19061211
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14922485
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13197966
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10094470
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08011051
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07865449
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05057459
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03807568
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03429529
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03192068
82KDM2B_26808549_Chip-Seq_K562_Human1.02940074
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02781162
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01538257
85GATA2_19941826_ChIP-Seq_K562_Human1.00749827
86* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98243154
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97921422
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97287210
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95654515
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94909527
91TFEB_21752829_ChIP-Seq_HELA_Human0.94226774
92P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93540375
93BCOR_27268052_Chip-Seq_Bcells_Human0.90812069
94ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90284797
95GATA3_26560356_Chip-Seq_TH2_Human0.90246325
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.88992940
97TP63_17297297_ChIP-ChIP_HaCaT_Human0.88964140
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88350739
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87386497
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.87267069
101SA1_27219007_Chip-Seq_ERYTHROID_Human0.86936454
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.84856681
103* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84013728
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83741634
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.82807630
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82038516
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78046145
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78046145
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78046145
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77948224
111GATA1_22025678_ChIP-Seq_K562_Human0.77617852
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77493164
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77150806
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.75707102
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74966828
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.74526755
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74181114
118FOXP3_21729870_ChIP-Seq_TREG_Human0.72898499
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72371302
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71977053
121LXR_22292898_ChIP-Seq_THP-1_Human0.71721922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.56079226
2MP0005671_abnormal_response_to2.89652797
3MP0000685_abnormal_immune_system2.87519553
4MP0001800_abnormal_humoral_immune2.87283251
5MP0002396_abnormal_hematopoietic_system2.75567557
6MP0003436_decreased_susceptibility_to2.75454813
7MP0003303_peritoneal_inflammation2.72173116
8MP0005387_immune_system_phenotype2.67741305
9MP0001790_abnormal_immune_system2.67741305
10MP0003763_abnormal_thymus_physiology2.61015937
11MP0005000_abnormal_immune_tolerance2.56500851
12* MP0002452_abnormal_antigen_presenting2.50327152
13MP0005451_abnormal_body_composition2.42267992
14MP0006082_CNS_inflammation2.39700590
15MP0002723_abnormal_immune_serum2.37355481
16MP0009785_altered_susceptibility_to2.37162639
17* MP0002420_abnormal_adaptive_immunity2.36654016
18* MP0001819_abnormal_immune_cell2.34810742
19* MP0002398_abnormal_bone_marrow2.29325977
20MP0005025_abnormal_response_to2.26364898
21MP0010352_gastrointestinal_tract_polyps2.23711496
22MP0003300_gastrointestinal_ulcer2.22530111
23MP0003191_abnormal_cellular_cholesterol2.12780501
24MP0002419_abnormal_innate_immunity2.09169843
25MP0002405_respiratory_system_inflammati2.07164126
26* MP0000716_abnormal_immune_system2.05421745
27MP0002148_abnormal_hypersensitivity_rea1.98583259
28MP0009333_abnormal_splenocyte_physiolog1.96994941
29MP0009278_abnormal_bone_marrow1.94477329
30MP0002166_altered_tumor_susceptibility1.93889110
31MP0010155_abnormal_intestine_physiology1.93776378
32MP0000689_abnormal_spleen_morphology1.91018078
33* MP0002722_abnormal_immune_system1.90719423
34* MP0004808_abnormal_hematopoietic_stem1.87468760
35MP0004947_skin_inflammation1.85221408
36MP0008260_abnormal_autophagy1.83488632
37MP0005464_abnormal_platelet_physiology1.81528907
38MP0001873_stomach_inflammation1.79042008
39MP0000703_abnormal_thymus_morphology1.77370541
40* MP0002429_abnormal_blood_cell1.76406895
41MP0001545_abnormal_hematopoietic_system1.68430120
42MP0005397_hematopoietic_system_phenotyp1.68430120
43MP0002006_tumorigenesis1.67442729
44MP0001853_heart_inflammation1.61438443
45MP0000490_abnormal_crypts_of1.57914706
46* MP0001845_abnormal_inflammatory_respons1.52553214
47MP0004510_myositis1.46191383
48MP0003448_altered_tumor_morphology1.46041763
49MP0008057_abnormal_DNA_replication1.45448641
50MP0000858_altered_metastatic_potential1.45096066
51MP0003724_increased_susceptibility_to1.44965805
52MP0005076_abnormal_cell_differentiation1.39213867
53MP0000465_gastrointestinal_hemorrhage1.37379827
54MP0003566_abnormal_cell_adhesion1.34417316
55MP0009840_abnormal_foam_cell1.32277407
56MP0001533_abnormal_skeleton_physiology1.31118844
57MP0010307_abnormal_tumor_latency1.27034530
58MP0002933_joint_inflammation1.26558619
59MP0003705_abnormal_hypodermis_morpholog1.26505750
60MP0003075_altered_response_to1.22599642
61MP0003866_abnormal_defecation1.22549473
62MP0005310_abnormal_salivary_gland1.20208355
63MP0003828_pulmonary_edema1.19028636
64MP0003656_abnormal_erythrocyte_physiolo1.17662515
65MP0005023_abnormal_wound_healing1.13974510
66MP0003183_abnormal_peptide_metabolism1.12046951
67MP0005075_abnormal_melanosome_morpholog1.10856077
68MP0003077_abnormal_cell_cycle1.10215773
69MP0008004_abnormal_stomach_pH1.10153801
70MP0002019_abnormal_tumor_incidence1.09116424
71MP0004883_abnormal_blood_vessel1.06263474
72MP0004264_abnormal_extraembryonic_tissu1.05742110
73MP0005164_abnormal_response_to1.05293101
74MP0008469_abnormal_protein_level1.02501581
75MP0005166_decreased_susceptibility_to1.01084897
76MP0000343_altered_response_to0.99711996
77MP0008961_abnormal_basal_metabolism0.99686236
78MP0005174_abnormal_tail_pigmentation0.99363661
79MP0003172_abnormal_lysosome_physiology0.98652689
80MP0006054_spinal_hemorrhage0.96333024
81MP0003693_abnormal_embryo_hatching0.95955489
82MP0001851_eye_inflammation0.93966625
83MP0004957_abnormal_blastocyst_morpholog0.92697495
84MP0002254_reproductive_system_inflammat0.91446885
85MP0010094_abnormal_chromosome_stability0.91141698
86MP0002998_abnormal_bone_remodeling0.90452442
87MP0003091_abnormal_cell_migration0.88116602
88MP0000604_amyloidosis0.86383450
89MP0000350_abnormal_cell_proliferation0.85520543
90MP0002132_abnormal_respiratory_system0.84762645
91MP0004185_abnormal_adipocyte_glucose0.81108096
92MP0009763_increased_sensitivity_to0.80978214
93MP0003453_abnormal_keratinocyte_physiol0.80502907
94MP0003111_abnormal_nucleus_morphology0.79335334
95MP0000313_abnormal_cell_death0.78685111
96MP0008007_abnormal_cellular_replicative0.77570824
97MP0002877_abnormal_melanocyte_morpholog0.77492709
98MP0005058_abnormal_lysosome_morphology0.77470471
99MP0003279_aneurysm0.77263517
100MP0002009_preneoplasia0.76695910
101MP0001663_abnormal_digestive_system0.76175444
102MP0010234_abnormal_vibrissa_follicle0.75941477
103MP0003984_embryonic_growth_retardation0.74419457
104MP0003221_abnormal_cardiomyocyte_apopto0.74154937
105MP0002088_abnormal_embryonic_growth/wei0.73901778
106MP0002086_abnormal_extraembryonic_tissu0.73765646
107MP0000569_abnormal_digit_pigmentation0.73662659
108MP0005390_skeleton_phenotype0.73376632
109MP0003045_fibrosis0.73262178
110MP0004381_abnormal_hair_follicle0.72852478
111MP0002332_abnormal_exercise_endurance0.69069743
112MP0003690_abnormal_glial_cell0.68355657
113MP0000249_abnormal_blood_vessel0.67735938
114MP0001849_ear_inflammation0.67364582
115MP0000477_abnormal_intestine_morphology0.65855893
116MP0002138_abnormal_hepatobiliary_system0.65616202
117MP0005621_abnormal_cell_physiology0.64944590
118MP0003795_abnormal_bone_structure0.64916319
119MP0005409_darkened_coat_color0.64591836
120MP0009764_decreased_sensitivity_to0.64002185
121MP0005380_embryogenesis_phenotype0.63748824
122MP0001672_abnormal_embryogenesis/_devel0.63748824
123MP0000767_abnormal_smooth_muscle0.63305793
124MP0001243_abnormal_dermal_layer0.63195353
125MP0002796_impaired_skin_barrier0.61641830

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)4.23627207
2Eczematoid dermatitis (HP:0000976)4.09607574
3Recurrent abscess formation (HP:0002722)4.04511571
4Myositis (HP:0100614)3.95628596
5Recurrent fungal infections (HP:0002841)3.95387048
6Elevated erythrocyte sedimentation rate (HP:0003565)3.92282264
7Cellulitis (HP:0100658)3.65837603
8T lymphocytopenia (HP:0005403)3.63469250
9Recurrent bacterial skin infections (HP:0005406)3.60566076
10Abnormality of T cell number (HP:0011839)3.49309055
11Nasal polyposis (HP:0100582)3.44671824
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.41080551
13IgM deficiency (HP:0002850)3.39350029
14Panhypogammaglobulinemia (HP:0003139)3.36349434
15Orchitis (HP:0100796)3.24632324
16Abnormality of the fingertips (HP:0001211)3.18379498
17Recurrent bronchitis (HP:0002837)3.16405276
18Gastrointestinal infarctions (HP:0005244)3.16125646
19Autoimmune thrombocytopenia (HP:0001973)3.15167588
20Abnormality of the nasal mucosa (HP:0000433)3.13497100
21Abnormality of T cells (HP:0002843)3.12658114
22Meningitis (HP:0001287)3.06971695
23Agammaglobulinemia (HP:0004432)3.05394164
24Chronic otitis media (HP:0000389)3.03915577
25Spontaneous hematomas (HP:0007420)2.96609539
26Recurrent cutaneous fungal infections (HP:0011370)2.95596123
27Chronic mucocutaneous candidiasis (HP:0002728)2.95596123
28Abnormality of liposaccharide metabolism (HP:0010968)2.89804743
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.89804743
30Abnormality of glycolipid metabolism (HP:0010969)2.89804743
31Inflammation of the large intestine (HP:0002037)2.87384790
32Vasculitis (HP:0002633)2.85885650
33Gastrointestinal inflammation (HP:0004386)2.83414867
34Urticaria (HP:0001025)2.83319604
35Mediastinal lymphadenopathy (HP:0100721)2.82842611
36Combined immunodeficiency (HP:0005387)2.81922089
37Pustule (HP:0200039)2.73458628
38Abnormality of T cell physiology (HP:0011840)2.70436852
39Recurrent skin infections (HP:0001581)2.70003871
40Colitis (HP:0002583)2.67133668
41B lymphocytopenia (HP:0010976)2.63023838
42Abnormality of B cell number (HP:0010975)2.63023838
43Eosinophilia (HP:0001880)2.61213072
44Petechiae (HP:0000967)2.57887206
45Obstructive lung disease (HP:0006536)2.57069528
46Chronic obstructive pulmonary disease (HP:0006510)2.57069528
47Leukocytosis (HP:0001974)2.54637778
48Periodontitis (HP:0000704)2.53376008
49Thrombocytosis (HP:0001894)2.52879524
50Increased cerebral lipofuscin (HP:0011813)2.52707182
51Thyroiditis (HP:0100646)2.51223267
52Verrucae (HP:0200043)2.49807321
53Papilloma (HP:0012740)2.49807321
54Retrobulbar optic neuritis (HP:0100654)2.49510886
55Optic neuritis (HP:0100653)2.49510886
56Dysostosis multiplex (HP:0000943)2.49347156
57Chest pain (HP:0100749)2.48993732
58Prolonged bleeding time (HP:0003010)2.43652369
59Keratoconjunctivitis (HP:0001096)2.43438826
60Lymphopenia (HP:0001888)2.42197552
61Amyloidosis (HP:0011034)2.40672212
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.36684890
63Abnormality of macrophages (HP:0004311)2.35154259
64Gingivitis (HP:0000230)2.34493827
65Loss of speech (HP:0002371)2.31779434
66Recurrent gram-negative bacterial infections (HP:0005420)2.31578950
67Increased IgE level (HP:0003212)2.30910196
68Hematochezia (HP:0002573)2.30285946
69Pulmonary infiltrates (HP:0002113)2.28032526
70Granulocytopenia (HP:0001913)2.24622886
71Osteomyelitis (HP:0002754)2.23244105
72Abnormality of eosinophils (HP:0001879)2.23046728
73Encephalitis (HP:0002383)2.22350310
74Arterial thrombosis (HP:0004420)2.21585579
75Interstitial pulmonary disease (HP:0006530)2.21232911
76Increased serum ferritin (HP:0003281)2.20724424
77Severe combined immunodeficiency (HP:0004430)2.20493239
78Episodic fever (HP:0001954)2.18242231
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17611587
80Hemoptysis (HP:0002105)2.15993035
81Increased IgM level (HP:0003496)2.15462307
82Stomatitis (HP:0010280)2.13679969
83Cheilitis (HP:0100825)2.10770925
84Slow saccadic eye movements (HP:0000514)2.10677869
85Polycythemia (HP:0001901)2.08888211
86Epistaxis (HP:0000421)2.08445654
87Emphysema (HP:0002097)2.07861638
88Abnormal platelet volume (HP:0011876)2.07512429
89Syringomyelia (HP:0003396)2.06978339
90Spinal cord lesions (HP:0100561)2.06978339
91Abnormality of the peritoneum (HP:0002585)2.06004169
92IgG deficiency (HP:0004315)2.04843958
93Fatigue (HP:0012378)2.04807195
94Gastrointestinal stroma tumor (HP:0100723)2.03253079
95Gingival bleeding (HP:0000225)2.02817680
96IgA deficiency (HP:0002720)2.02172755
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.00737123
98Vacuolated lymphocytes (HP:0001922)2.00515173
99Autoimmune hemolytic anemia (HP:0001890)1.99466512
100Lymphoma (HP:0002665)1.98723979
101Hypertensive crisis (HP:0100735)1.97525475
102Increased density of long bones (HP:0006392)1.96472886
103Hypochromic anemia (HP:0001931)1.96151702
104Anorexia (HP:0002039)1.95423563
105Purpura (HP:0000979)1.94828261
106Glomerulopathy (HP:0100820)1.94716794
107Segmental peripheral demyelination/remyelination (HP:0003481)1.94649709
108Absent frontal sinuses (HP:0002688)1.94412602
109Impaired platelet aggregation (HP:0003540)1.94402825
110Abnormal platelet function (HP:0011869)1.94402825
111Skin ulcer (HP:0200042)1.92561256
112Abnormality of polysaccharide metabolism (HP:0011012)1.91830095
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91830095
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91830095
115Urinary glycosaminoglycan excretion (HP:0003541)1.90951021
116Mucopolysacchariduria (HP:0008155)1.90951021
117Restrictive lung disease (HP:0002091)1.89826254
118Hepatosplenomegaly (HP:0001433)1.87430168
119Chronic diarrhea (HP:0002028)1.85923365
120Pulmonary embolism (HP:0002204)1.84621205
121Dilatation of the ascending aorta (HP:0005111)1.84502024
122Polygenic inheritance (HP:0010982)1.84306096
123Myocardial infarction (HP:0001658)1.83490969
124Gangrene (HP:0100758)1.83415693
125Malnutrition (HP:0004395)1.81944445
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.81885278
127Osteolytic defects of the hand bones (HP:0009699)1.81885278
128Recurrent lower respiratory tract infections (HP:0002783)1.81194689
129Premature loss of primary teeth (HP:0006323)1.80804345
130Abnormality of the pleura (HP:0002103)1.80382018
131Viral hepatitis (HP:0006562)1.79553015
132Abnormality of the prostate (HP:0008775)1.79212869
133Spondylolisthesis (HP:0003302)1.78067287
134Acute myeloid leukemia (HP:0004808)1.72769279
135Sepsis (HP:0100806)1.72514410
136Keratoconjunctivitis sicca (HP:0001097)1.71615351
137Hypergammaglobulinemia (HP:0010702)1.69936898
138Peritonitis (HP:0002586)1.69178344
139Cerebral aneurysm (HP:0004944)1.68629844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.29723633
2PRPF4B3.71165687
3CDK123.67738469
4ERN13.22709913
5STK102.92121325
6GRK62.68225441
7MAP3K102.64240900
8TXK2.52311360
9JAK32.23377606
10TYK22.22683158
11CSF1R2.13759675
12EEF2K2.13235307
13TGFBR22.06906008
14ZAP701.95576005
15BLK1.86862844
16TRIB31.83845236
17ITK1.80095057
18MAP3K31.74749541
19MAP3K141.68494350
20TBK11.62641458
21FGFR31.61124238
22BTK1.59966069
23SMG11.59407368
24KIT1.57853532
25TAOK21.57224525
26CSK1.56655173
27PKN21.55012607
28IRAK41.46722157
29JAK11.45898109
30IKBKB1.42160148
31LRRK21.38121170
32IKBKE1.37954562
33SYK1.36874095
34HCK1.34660590
35FGR1.34153852
36MAP3K11.33824586
37RPS6KA41.33396258
38KSR21.33334461
39RIPK41.33293794
40SIK21.28354182
41TEC1.23952091
42LCK1.22211248
43MAP3K111.20139240
44PIM11.19267066
45BMPR21.18257459
46EPHB11.15330671
47MATK1.08720780
48MAP2K31.08492648
49NEK21.07468393
50FGFR41.07291152
51IRAK21.07177498
52CLK11.05869832
53CDC42BPA1.05050452
54CHUK1.02667269
55STK41.00104060
56MARK30.98051448
57CDK40.97259877
58ICK0.94830838
59IRAK10.94754151
60TTN0.92727651
61PRKD20.86266556
62NLK0.80575548
63PTK60.79650435
64MAP3K130.79596643
65HIPK20.78692452
66PDPK10.78457264
67LYN0.78233062
68IRAK30.77700363
69PAK40.77494409
70FLT30.77192475
71YES10.76702828
72TRPM70.74998213
73MAPK70.74632504
74SIK30.74317530
75PDK10.73322160
76FES0.73026109
77NEK90.72693465
78CDK60.72287394
79TAOK30.71646229
80MST40.71030907
81JAK20.70215871
82MOS0.69121555
83STK30.67884991
84PIM20.67197049
85ALK0.65739947
86MAP3K70.65394056
87STK240.65108320
88MAP3K60.63372025
89MAP3K20.62606353
90RPS6KB20.61130125
91PRKG20.59484726
92MAP3K80.59356015
93CDK70.58614272
94KDR0.57775483
95TGFBR10.57408714
96RIPK10.57222034
97NME20.55538509
98MAPK120.53247005
99DMPK0.52391837
100PRKCQ0.52313937
101CAMK1D0.51040545
102BRD40.50969257
103RPS6KL10.50786971
104RPS6KC10.50786971
105MAPK110.50629320
106TAOK10.50055684
107MAPKAPK20.50035641
108PDGFRB0.49077656
109MELK0.48132055
110SIK10.45101990
111TNK20.43811079
112CDK90.43171402
113PRKCH0.42404027
114BMX0.41562552
115MTOR0.41277473
116ADRBK20.40737806
117SGK30.40411069
118RPS6KA20.39307827
119CDC70.39111476
120MAPK40.38986244
121GRK70.38977195
122EPHA30.38959139
123FYN0.38806899
124EGFR0.38116738
125TESK20.36982348
126KSR10.36471937
127MARK20.35639292
128SCYL20.35235605

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.17852542
2Leishmaniasis_Homo sapiens_hsa051402.55405615
3B cell receptor signaling pathway_Homo sapiens_hsa046622.45068174
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.33823269
5Osteoclast differentiation_Homo sapiens_hsa043802.10889065
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10313702
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.09942159
8Measles_Homo sapiens_hsa051622.04890191
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00297700
10Antigen processing and presentation_Homo sapiens_hsa046121.96393113
11T cell receptor signaling pathway_Homo sapiens_hsa046601.95790776
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90895469
13Hematopoietic cell lineage_Homo sapiens_hsa046401.84422437
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.77823595
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67620303
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66064579
17Herpes simplex infection_Homo sapiens_hsa051681.62662344
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61583558
19Toxoplasmosis_Homo sapiens_hsa051451.61361945
20Acute myeloid leukemia_Homo sapiens_hsa052211.55713421
21Graft-versus-host disease_Homo sapiens_hsa053321.53914688
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53379451
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.53368645
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.49460426
25Allograft rejection_Homo sapiens_hsa053301.47861176
26Legionellosis_Homo sapiens_hsa051341.44948694
27Chronic myeloid leukemia_Homo sapiens_hsa052201.42270158
28Influenza A_Homo sapiens_hsa051641.41842092
29Apoptosis_Homo sapiens_hsa042101.41691283
30TNF signaling pathway_Homo sapiens_hsa046681.36346975
31Viral myocarditis_Homo sapiens_hsa054161.35521663
32Hepatitis B_Homo sapiens_hsa051611.34903083
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33690107
34Shigellosis_Homo sapiens_hsa051311.33661533
35Tuberculosis_Homo sapiens_hsa051521.32235363
36Chemokine signaling pathway_Homo sapiens_hsa040621.28837676
37Malaria_Homo sapiens_hsa051441.27159288
38Pancreatic cancer_Homo sapiens_hsa052121.24968570
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24206008
40Pertussis_Homo sapiens_hsa051331.22406948
41Platelet activation_Homo sapiens_hsa046111.20046255
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18014972
43Staphylococcus aureus infection_Homo sapiens_hsa051501.14965651
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12390265
45Asthma_Homo sapiens_hsa053101.09814082
46Phagosome_Homo sapiens_hsa041451.08973760
47Small cell lung cancer_Homo sapiens_hsa052221.07874264
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06951273
49Rheumatoid arthritis_Homo sapiens_hsa053231.02859816
50HTLV-I infection_Homo sapiens_hsa051661.01341005
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00632192
52Other glycan degradation_Homo sapiens_hsa005110.99473600
53Salmonella infection_Homo sapiens_hsa051320.98444726
54DNA replication_Homo sapiens_hsa030300.98142448
55Bladder cancer_Homo sapiens_hsa052190.95544543
56Viral carcinogenesis_Homo sapiens_hsa052030.95032734
57Non-small cell lung cancer_Homo sapiens_hsa052230.93895253
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.92890558
59Epstein-Barr virus infection_Homo sapiens_hsa051690.89826129
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.89408615
61Hepatitis C_Homo sapiens_hsa051600.86362473
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85709333
63Colorectal cancer_Homo sapiens_hsa052100.84743462
64MicroRNAs in cancer_Homo sapiens_hsa052060.83045655
65p53 signaling pathway_Homo sapiens_hsa041150.82978150
66VEGF signaling pathway_Homo sapiens_hsa043700.80834099
67Autoimmune thyroid disease_Homo sapiens_hsa053200.80316698
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79457229
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79181425
70Base excision repair_Homo sapiens_hsa034100.78413315
71Notch signaling pathway_Homo sapiens_hsa043300.75815775
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74445424
73mTOR signaling pathway_Homo sapiens_hsa041500.74105575
74Prolactin signaling pathway_Homo sapiens_hsa049170.73900289
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72453842
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72304500
77Cell cycle_Homo sapiens_hsa041100.71307090
78Non-homologous end-joining_Homo sapiens_hsa034500.69573221
79Proteoglycans in cancer_Homo sapiens_hsa052050.68743962
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.65911165
81GnRH signaling pathway_Homo sapiens_hsa049120.65454123
82Thyroid cancer_Homo sapiens_hsa052160.62728600
83ErbB signaling pathway_Homo sapiens_hsa040120.61637772
84Choline metabolism in cancer_Homo sapiens_hsa052310.60216939
85HIF-1 signaling pathway_Homo sapiens_hsa040660.59848806
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59709330
87African trypanosomiasis_Homo sapiens_hsa051430.58872270
88Ribosome_Homo sapiens_hsa030100.56093370
89FoxO signaling pathway_Homo sapiens_hsa040680.55787622
90Lysosome_Homo sapiens_hsa041420.55556428
91Insulin resistance_Homo sapiens_hsa049310.54399318
92Focal adhesion_Homo sapiens_hsa045100.54150746
93Adherens junction_Homo sapiens_hsa045200.53683651
94Glioma_Homo sapiens_hsa052140.53103187
95Mismatch repair_Homo sapiens_hsa034300.52959646
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.52944342
97Pathways in cancer_Homo sapiens_hsa052000.52891321
98Dorso-ventral axis formation_Homo sapiens_hsa043200.52477443
99Amoebiasis_Homo sapiens_hsa051460.51986531
100Prostate cancer_Homo sapiens_hsa052150.51497426
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50919828
102Spliceosome_Homo sapiens_hsa030400.50216493
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50051744
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47957304
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47954724
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.47867906
107Inositol phosphate metabolism_Homo sapiens_hsa005620.46034277
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46012304
109Prion diseases_Homo sapiens_hsa050200.45968282
110Insulin signaling pathway_Homo sapiens_hsa049100.45860857
111Type II diabetes mellitus_Homo sapiens_hsa049300.44957495
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44688441
113Endometrial cancer_Homo sapiens_hsa052130.43779993
114Renal cell carcinoma_Homo sapiens_hsa052110.42860511
115Endocytosis_Homo sapiens_hsa041440.40231807
116mRNA surveillance pathway_Homo sapiens_hsa030150.40014136
117Lysine degradation_Homo sapiens_hsa003100.39415241
118Type I diabetes mellitus_Homo sapiens_hsa049400.39218175
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.38143369
120RNA transport_Homo sapiens_hsa030130.37788447

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