ELF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine-containing compound transmembrane transport (GO:0072531)8.19784345
2lactation (GO:0007595)6.78721679
3regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.14729577
4long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.94210539
5fatty-acyl-CoA biosynthetic process (GO:0046949)5.91239020
6secretion by tissue (GO:0032941)5.91231370
7thioester biosynthetic process (GO:0035384)5.67908414
8acyl-CoA biosynthetic process (GO:0071616)5.67908414
9nucleoside transmembrane transport (GO:1901642)5.58682991
10segment specification (GO:0007379)5.53124207
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.45940976
12linoleic acid metabolic process (GO:0043651)5.40411746
13body fluid secretion (GO:0007589)4.98930372
14positive regulation of p38MAPK cascade (GO:1900745)4.87574255
15copper ion transport (GO:0006825)4.81488415
16regulation of sequestering of triglyceride (GO:0010889)4.79069566
17regulation of apoptotic process involved in morphogenesis (GO:1902337)4.78594195
18regulation of clathrin-mediated endocytosis (GO:2000369)4.68518049
19intestinal cholesterol absorption (GO:0030299)4.56387187
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.49096589
21prostate gland growth (GO:0060736)4.33208019
22biotin metabolic process (GO:0006768)4.32148540
23glutathione biosynthetic process (GO:0006750)4.28352147
24tooth mineralization (GO:0034505)4.27015961
25O-glycan processing (GO:0016266)4.26957668
26nucleoside transport (GO:0015858)4.23301822
27negative regulation of keratinocyte proliferation (GO:0010839)4.18189102
28nonribosomal peptide biosynthetic process (GO:0019184)4.14292770
29growth hormone receptor signaling pathway (GO:0060396)4.11881697
30negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.11515328
31N-acetylneuraminate metabolic process (GO:0006054)4.03290685
32type B pancreatic cell proliferation (GO:0044342)4.02439833
33mammary gland development (GO:0030879)4.00762226
34Golgi transport vesicle coating (GO:0048200)3.99774571
35COPI coating of Golgi vesicle (GO:0048205)3.99774571
36fatty-acyl-CoA metabolic process (GO:0035337)3.97924905
37regulation of penile erection (GO:0060405)3.96776395
38embryonic process involved in female pregnancy (GO:0060136)3.96373844
39peristalsis (GO:0030432)3.92524362
40branched-chain amino acid catabolic process (GO:0009083)3.92181086
41keratinocyte development (GO:0003334)3.87534355
42alpha-linolenic acid metabolic process (GO:0036109)3.86783164
43detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.83379696
44oligosaccharide metabolic process (GO:0009311)3.83250990
45regulation of phospholipid biosynthetic process (GO:0071071)3.75984183
46negative regulation of execution phase of apoptosis (GO:1900118)3.74781065
47regulation of hippo signaling (GO:0035330)3.72364447
48branched-chain amino acid metabolic process (GO:0009081)3.71271666
49surfactant homeostasis (GO:0043129)3.69801908
50lipid storage (GO:0019915)3.65024205
51short-chain fatty acid metabolic process (GO:0046459)3.62750279
52folic acid transport (GO:0015884)3.61856489
53iron ion import (GO:0097286)3.61227725
54chemical homeostasis within a tissue (GO:0048875)3.58686476
55proximal/distal pattern formation (GO:0009954)3.57645388
56positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.57205945
57intestinal epithelial cell development (GO:0060576)3.56296235
58* mammary gland epithelial cell differentiation (GO:0060644)3.53585756
59phagocytosis, recognition (GO:0006910)3.52898574
60negative regulation of protein kinase B signaling (GO:0051898)3.52815091
61regulation of vasculogenesis (GO:2001212)3.50252185
62galactose metabolic process (GO:0006012)3.47351296
63positive regulation of lipid storage (GO:0010884)3.45809072
64urinary tract smooth muscle contraction (GO:0014848)3.44434989
65cellular response to growth hormone stimulus (GO:0071378)3.43396294
66hemidesmosome assembly (GO:0031581)3.40805715
67sterol catabolic process (GO:0016127)3.37973118
68cholesterol catabolic process (GO:0006707)3.37973118
69retina homeostasis (GO:0001895)3.36047283
70pantothenate metabolic process (GO:0015939)3.35918622
71valine metabolic process (GO:0006573)3.33172083
72negative regulation of transcription by competitive promoter binding (GO:0010944)3.32698884
73positive regulation of natural killer cell differentiation (GO:0032825)3.31077708
74regulation of water loss via skin (GO:0033561)3.29071678
75regulation of endothelial cell differentiation (GO:0045601)3.24973817
76negative regulation of fatty acid transport (GO:2000192)3.23726781
77positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.23476782
78angiogenesis involved in wound healing (GO:0060055)3.22294568
79negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.21720352
80regulation of autophagic vacuole assembly (GO:2000785)3.21682105
81fatty acid transmembrane transport (GO:1902001)3.20995864
82intestinal absorption (GO:0050892)3.20688064
83citrulline biosynthetic process (GO:0019240)3.20081881
84triglyceride biosynthetic process (GO:0019432)3.19715954
85regulation of p38MAPK cascade (GO:1900744)3.18872862
86epithelial cell maturation (GO:0002070)3.17818226
87mammary gland alveolus development (GO:0060749)3.16620497
88diol metabolic process (GO:0034311)3.14550198
89carnitine shuttle (GO:0006853)3.14071289
90interferon-gamma secretion (GO:0072643)3.13965854
91establishment of skin barrier (GO:0061436)3.12596297
92ethanol metabolic process (GO:0006067)3.11344981
93desmosome organization (GO:0002934)3.11339455
94regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.10863688
95primary alcohol catabolic process (GO:0034310)3.10579544
96sphingoid metabolic process (GO:0046519)3.09038276
97nucleobase catabolic process (GO:0046113)3.09013499
98ear development (GO:0043583)3.07093176
99superoxide anion generation (GO:0042554)3.06643097
100nucleoside diphosphate catabolic process (GO:0009134)3.05158360
101glutathione derivative metabolic process (GO:1901685)3.04163025
102glutathione derivative biosynthetic process (GO:1901687)3.04163025
103phospholipid homeostasis (GO:0055091)3.03589846
104negative regulation of cell fate commitment (GO:0010454)3.03353995
105neutral lipid biosynthetic process (GO:0046460)3.03208230
106acylglycerol biosynthetic process (GO:0046463)3.03208230
107one-carbon compound transport (GO:0019755)3.03030199
108positive regulation of macrophage cytokine production (GO:0060907)3.02524523
109response to phenylpropanoid (GO:0080184)3.02302021
110mitochondrial calcium ion transport (GO:0006851)3.02173746
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98908217
112ceramide catabolic process (GO:0046514)2.96841055
113multicellular organismal water homeostasis (GO:0050891)2.96452356
114peptide biosynthetic process (GO:0043043)2.96399510
115acetyl-CoA metabolic process (GO:0006084)2.93906716
116regulation of triglyceride biosynthetic process (GO:0010866)2.91220226
117hydrogen peroxide biosynthetic process (GO:0050665)2.91201730
118positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.90419537
119regulation of macrophage cytokine production (GO:0010935)2.89917831
120detection of molecule of bacterial origin (GO:0032490)2.89652641
121response to progesterone (GO:0032570)2.86949097
122zinc ion transport (GO:0006829)2.85500074
123GDP-mannose metabolic process (GO:0019673)2.85096381
124regulation of fatty acid oxidation (GO:0046320)2.84244557
125regulation of interleukin-13 production (GO:0032656)2.83516323
126nucleotide transmembrane transport (GO:1901679)2.82927281
127activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.80458564
128protein O-linked glycosylation (GO:0006493)2.80432228
129regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.80268091
130positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.79484438
131negative regulation of erythrocyte differentiation (GO:0045647)2.77546481
132endocrine hormone secretion (GO:0060986)2.76703530
133cardiac right ventricle morphogenesis (GO:0003215)2.76459830
134amino-acid betaine metabolic process (GO:0006577)2.76286332
135carnitine metabolic process (GO:0009437)2.75795817
136negative regulation of systemic arterial blood pressure (GO:0003085)2.75385284
137phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.73661682
138xenobiotic catabolic process (GO:0042178)2.73120894
139regulation of triglyceride metabolic process (GO:0090207)2.72040242
140bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70138281
141gland morphogenesis (GO:0022612)2.70102912
142trivalent inorganic anion homeostasis (GO:0072506)2.69711518
143phosphate ion homeostasis (GO:0055062)2.69711518
144proline biosynthetic process (GO:0006561)2.69083280
145dicarboxylic acid catabolic process (GO:0043649)2.68983227
146calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.68970600
147transcytosis (GO:0045056)2.68854929
148phasic smooth muscle contraction (GO:0014821)2.68677669
149DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.68048071
150lung lobe morphogenesis (GO:0060463)2.67654683
151endocardial cushion morphogenesis (GO:0003203)2.66542846
152positive regulation of tissue remodeling (GO:0034105)2.64906621
153long-chain fatty acid transport (GO:0015909)2.63307594
154cellular response to vitamin D (GO:0071305)2.62013465
155regulation of acrosome reaction (GO:0060046)2.60040207
156detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.58711643
157water homeostasis (GO:0030104)2.58292066
158reactive oxygen species biosynthetic process (GO:1903409)2.58039635
159axoneme assembly (GO:0035082)2.57048536
160cell differentiation involved in metanephros development (GO:0072202)2.54151575
161L-serine transport (GO:0015825)2.52833594
162pattern specification involved in kidney development (GO:0061004)11.3639016
163oligosaccharide biosynthetic process (GO:0009312)10.3526335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse7.92877828
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.48701192
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.45083236
4ESR2_21235772_ChIP-Seq_MCF-7_Human4.30054430
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.60029521
6ZNF217_24962896_ChIP-Seq_MCF-7_Human3.07722276
7ELF5_23300383_ChIP-Seq_T47D_Human2.92790995
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.65674945
9AR_21572438_ChIP-Seq_LNCaP_Human2.60741745
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.57950386
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.49775418
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46155555
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36701164
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31910761
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23331347
16SOX2_20726797_ChIP-Seq_SW620_Human2.23040107
17ZNF263_19887448_ChIP-Seq_K562_Human2.17546474
18VDR_22108803_ChIP-Seq_LS180_Human2.14454426
19AHR_22903824_ChIP-Seq_MCF-7_Human2.07087957
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.02395619
21HOXB7_26014856_ChIP-Seq_BT474_Human2.02063417
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01620653
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96514266
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.90186618
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88393361
26GATA4_25053715_ChIP-Seq_YYC3_Human1.84390758
27CLOCK_20551151_ChIP-Seq_293T_Human1.81938235
28* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81726177
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.76912596
30KDM5A_27292631_Chip-Seq_BREAST_Human1.73327300
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64097784
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62588827
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.62007023
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57828076
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.55526197
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55158147
37KLF5_25053715_ChIP-Seq_YYC3_Human1.53496746
38* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52626636
39TP53_18474530_ChIP-ChIP_U2OS_Human1.51817603
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48533704
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.46197179
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.45839253
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44807176
44FLI1_21867929_ChIP-Seq_CD8_Mouse1.44403387
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.43687312
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42202747
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.41920287
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40761196
49GATA3_24758297_ChIP-Seq_MCF-7_Human1.40309690
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38093691
51ZNF274_21170338_ChIP-Seq_K562_Hela1.37696619
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36827332
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33521019
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32419186
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32419186
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28034859
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27174363
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.26022480
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.24473531
60STAT1_20625510_ChIP-Seq_HELA_Human1.20109873
61AR_20517297_ChIP-Seq_VCAP_Human1.19171628
62FOXA1_25552417_ChIP-Seq_VCAP_Human1.15322880
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14684474
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13949487
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.11757504
66* CJUN_26792858_Chip-Seq_BT549_Human1.10535927
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10424658
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.10320514
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10320514
70* CBP_21632823_ChIP-Seq_H3396_Human1.08963912
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08111280
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07728452
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07594625
74TP63_23658742_ChIP-Seq_EP156T_Human1.07375827
75* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06024557
76P53_21459846_ChIP-Seq_SAOS-2_Human1.04834956
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03993221
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03935059
79ER_23166858_ChIP-Seq_MCF-7_Human1.02813556
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01886229
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.01604077
82FOXH1_21741376_ChIP-Seq_ESCs_Human1.01240943
83* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01147499
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00479250
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00479250
86AR_25329375_ChIP-Seq_VCAP_Human0.98693677
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97136503
88ERG_20517297_ChIP-Seq_VCAP_Human0.96758375
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95824770
90BCAT_22108803_ChIP-Seq_LS180_Human0.95285134
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94481631
92NANOG_19829295_ChIP-Seq_ESCs_Human0.94065825
93SOX2_19829295_ChIP-Seq_ESCs_Human0.94065825
94TCF4_22108803_ChIP-Seq_LS180_Human0.93557978
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93510581
96CBP_20019798_ChIP-Seq_JUKART_Human0.93486219
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93486219
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93424958
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93379551
100HTT_18923047_ChIP-ChIP_STHdh_Human0.91381571
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90860871
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90605684
103GATA6_25053715_ChIP-Seq_YYC3_Human0.90082456
104GATA1_22025678_ChIP-Seq_K562_Human0.89599313
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.87986396
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87141577
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87141220
108NANOG_20526341_ChIP-Seq_ESCs_Human0.86387458
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85692659
110NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85291783
111* RACK7_27058665_Chip-Seq_MCF-7_Human0.84907170
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84692320
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84502823
114RAC3_21632823_ChIP-Seq_H3396_Human0.84034113
115VDR_24787735_ChIP-Seq_THP-1_Human0.83940985
116SMC4_20622854_ChIP-Seq_HELA_Human0.83775929
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83138668
118STAT1_17558387_ChIP-Seq_HELA_Human0.83080970
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82937812
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82865307
121CEBPB_22108803_ChIP-Seq_LS180_Human0.82104148
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81956804
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81567939
124ERA_21632823_ChIP-Seq_H3396_Human0.81031061
125* RXR_22108803_ChIP-Seq_LS180_Human0.80753516
126OCT4_20526341_ChIP-Seq_ESCs_Human0.80659014
127TP63_22573176_ChIP-Seq_HFKS_Human0.80656149
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79901795
129TP53_16413492_ChIP-PET_HCT116_Human0.79546657
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.79148050
131GATA3_21878914_ChIP-Seq_MCF-7_Human0.78727721
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.78572666
133* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78422120
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78060492
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77133072
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76878490
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76004525
138TAF2_19829295_ChIP-Seq_ESCs_Human0.75724046
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75479891
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75415158
141RXR_22158963_ChIP-Seq_LIVER_Mouse0.74932410
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.74256307
143LXR_22158963_ChIP-Seq_LIVER_Mouse0.74014326
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72879253
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.72503665
146GABP_17652178_ChIP-ChIP_JURKAT_Human0.72306522
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72211318
148TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71010493
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70272536
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69878582
151* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69413859
152* SOX2_18555785_Chip-Seq_ESCs_Mouse0.69400053
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68632277
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.68273411
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68135782
156CHD1_26751641_Chip-Seq_LNCaP_Human0.67360324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.54086315
2MP0010234_abnormal_vibrissa_follicle4.51261745
3MP0002254_reproductive_system_inflammat3.15871262
4* MP0000627_abnormal_mammary_gland3.13194589
5MP0004264_abnormal_extraembryonic_tissu2.95105393
6MP0002098_abnormal_vibrissa_morphology2.70583491
7MP0001873_stomach_inflammation2.64798541
8MP0000566_synostosis2.48791413
9MP0002009_preneoplasia2.46926614
10MP0004019_abnormal_vitamin_homeostasis2.39521817
11MP0004147_increased_porphyrin_level2.39483745
12MP0002796_impaired_skin_barrier2.10453801
13MP0003300_gastrointestinal_ulcer2.00607862
14* MP0001881_abnormal_mammary_gland10.2060815
15MP0003718_maternal_effect1.99897592
16MP0005171_absent_coat_pigmentation1.96436880
17MP0004043_abnormal_pH_regulation1.94512279
18MP0005379_endocrine/exocrine_gland_phen1.89086735
19MP0004782_abnormal_surfactant_physiolog1.82788408
20MP0004381_abnormal_hair_follicle1.81224028
21MP0003011_delayed_dark_adaptation1.78180265
22MP0010678_abnormal_skin_adnexa1.75112933
23MP0005083_abnormal_biliary_tract1.68191614
24MP0000377_abnormal_hair_follicle1.54801312
25MP0008789_abnormal_olfactory_epithelium1.53048431
26MP0001346_abnormal_lacrimal_gland1.48050680
27MP0001664_abnormal_digestion1.42675817
28MP0005394_taste/olfaction_phenotype1.42411145
29MP0005499_abnormal_olfactory_system1.42411145
30MP0004130_abnormal_muscle_cell1.42075285
31MP0003303_peritoneal_inflammation1.37745966
32MP0002277_abnormal_respiratory_mucosa1.34458651
33MP0005410_abnormal_fertilization1.34389013
34MP0000579_abnormal_nail_morphology1.30977706
35MP0010386_abnormal_urinary_bladder1.30718069
36MP0005085_abnormal_gallbladder_physiolo1.30076348
37MP0005670_abnormal_white_adipose1.29566504
38MP0009780_abnormal_chondrocyte_physiolo1.28977723
39MP0001727_abnormal_embryo_implantation1.26451869
40MP0005646_abnormal_pituitary_gland1.25955017
41MP0000762_abnormal_tongue_morphology1.25315795
42MP0002060_abnormal_skin_morphology1.24165901
43MP0001177_atelectasis1.22428571
44MP0005501_abnormal_skin_physiology1.21239340
45MP0002653_abnormal_ependyma_morphology1.21012206
46MP0005395_other_phenotype1.18612274
47MP0003195_calcinosis1.18590828
48MP0000383_abnormal_hair_follicle1.15824860
49MP0001958_emphysema1.15823352
50MP0002876_abnormal_thyroid_physiology1.12300759
51MP0000613_abnormal_salivary_gland1.07523007
52MP0005310_abnormal_salivary_gland1.06927967
53MP0001216_abnormal_epidermal_layer1.05473959
54MP0000490_abnormal_crypts_of1.02613779
55MP0005275_abnormal_skin_tensile1.01484586
56MP0005075_abnormal_melanosome_morpholog0.96580713
57MP0001663_abnormal_digestive_system0.96391691
58MP0005408_hypopigmentation0.94480907
59MP0003566_abnormal_cell_adhesion0.94134640
60MP0005666_abnormal_adipose_tissue0.93852637
61MP0003453_abnormal_keratinocyte_physiol0.92846900
62MP0005389_reproductive_system_phenotype0.88823048
63MP0005645_abnormal_hypothalamus_physiol0.87579264
64MP0005381_digestive/alimentary_phenotyp0.87122911
65MP0005636_abnormal_mineral_homeostasis0.87015173
66MP0004272_abnormal_basement_membrane0.86317630
67MP0003638_abnormal_response/metabolism_0.85137672
68MP0001666_abnormal_nutrient_absorption0.82488436
69* MP0003936_abnormal_reproductive_system0.82046869
70MP0003448_altered_tumor_morphology0.79152989
71MP0008875_abnormal_xenobiotic_pharmacok0.78792029
72MP0001765_abnormal_ion_homeostasis0.77937663
73MP0002133_abnormal_respiratory_system0.77638642
74MP0005388_respiratory_system_phenotype0.77638642
75MP0002896_abnormal_bone_mineralization0.76947481
76MP0000427_abnormal_hair_cycle0.76858814
77MP0008995_early_reproductive_senescence0.76580445
78MP0002132_abnormal_respiratory_system0.76316955
79MP0000367_abnormal_coat/_hair0.76293355
80MP0000678_abnormal_parathyroid_gland0.75435736
81MP0005551_abnormal_eye_electrophysiolog0.74600331
82MP0002396_abnormal_hematopoietic_system0.74371658
83MP0002909_abnormal_adrenal_gland0.74346408
84MP0005248_abnormal_Harderian_gland0.74243203
85MP0003787_abnormal_imprinting0.73918539
86MP0009384_cardiac_valve_regurgitation0.73823819
87MP0003183_abnormal_peptide_metabolism0.73272228
88MP0005375_adipose_tissue_phenotype0.72667623
89MP0000470_abnormal_stomach_morphology0.71129220
90MP0008438_abnormal_cutaneous_collagen0.70994316
91MP0000858_altered_metastatic_potential0.69736990
92MP0004233_abnormal_muscle_weight0.69656588
93MP0004742_abnormal_vestibular_system0.69272955
94MP0000647_abnormal_sebaceous_gland0.69112358
95MP0010771_integument_phenotype0.68397956
96MP0000681_abnormal_thyroid_gland0.68327492
97MP0005334_abnormal_fat_pad0.67945445
98MP0005647_abnormal_sex_gland0.67636481
99MP0001919_abnormal_reproductive_system0.67497305
100MP0002295_abnormal_pulmonary_circulatio0.66646780
101MP0010352_gastrointestinal_tract_polyps0.66606890
102MP0002148_abnormal_hypersensitivity_rea0.66541083
103MP0005365_abnormal_bile_salt0.65601475
104MP0000462_abnormal_digestive_system0.65511891
105MP0001756_abnormal_urination0.64582606
106MP0010329_abnormal_lipoprotein_level0.63796482
107MP0002168_other_aberrant_phenotype0.63696184
108MP0002118_abnormal_lipid_homeostasis0.63508222
109MP0001849_ear_inflammation0.63148889
110MP0002233_abnormal_nose_morphology0.62991385
111MP0001984_abnormal_olfaction0.62457802
112MP0003959_abnormal_lean_body0.62335527
113MP0001851_eye_inflammation0.61945043
114MP0000516_abnormal_urinary_system0.61563951
115MP0005367_renal/urinary_system_phenotyp0.61563951
116MP0003191_abnormal_cellular_cholesterol0.61228342
117MP0003045_fibrosis0.61061972
118MP0005058_abnormal_lysosome_morphology0.60649190
119MP0002282_abnormal_trachea_morphology0.60335586
120MP0001188_hyperpigmentation0.59841333
121MP0002166_altered_tumor_susceptibility0.59192690
122MP0005220_abnormal_exocrine_pancreas0.58887408
123MP0000538_abnormal_urinary_bladder0.58367963
124MP0008961_abnormal_basal_metabolism0.58331378
125MP0008872_abnormal_physiological_respon0.57697153
126MP0009643_abnormal_urine_homeostasis0.56844372
127MP0005076_abnormal_cell_differentiation0.55782903
128MP0002998_abnormal_bone_remodeling0.53813981
129MP0004947_skin_inflammation0.53404043
130MP0002160_abnormal_reproductive_system0.53385415
131MP0003953_abnormal_hormone_level0.51897695
132MP0002693_abnormal_pancreas_physiology0.49239186
133MP0002751_abnormal_autonomic_nervous0.48787489
134MP0001502_abnormal_circadian_rhythm0.48253491
135MP0003938_abnormal_ear_development0.47897761
136MP0000631_abnormal_neuroendocrine_gland0.47730896
137MP0000371_diluted_coat_color0.47043355
138MP0005332_abnormal_amino_acid0.46925233
139MP0000537_abnormal_urethra_morphology0.46371500
140MP0002078_abnormal_glucose_homeostasis0.46155842
141MP0006276_abnormal_autonomic_nervous0.45686180
142MP0008004_abnormal_stomach_pH0.45283355
143MP0001944_abnormal_pancreas_morphology0.45025459

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.31836616
2Amelogenesis imperfecta (HP:0000705)5.59743026
3Curly hair (HP:0002212)4.90026336
4Congenital ichthyosiform erythroderma (HP:0007431)4.89888897
5Pili torti (HP:0003777)4.84214493
6Right ventricular cardiomyopathy (HP:0011663)4.64436549
7Flat capital femoral epiphysis (HP:0003370)4.58322777
8Tubulointerstitial nephritis (HP:0001970)4.33587605
9Hyperactive renin-angiotensin system (HP:0000841)4.13658828
10Abnormality of purine metabolism (HP:0004352)4.06105652
11Onycholysis (HP:0001806)3.99342535
12Decreased circulating renin level (HP:0003351)3.90114601
13Ectropion (HP:0000656)3.87584266
14Abnormality of the proximal phalanges of the hand (HP:0009834)3.82820427
15Aplasia cutis congenita (HP:0001057)3.55998914
16Atrophic scars (HP:0001075)3.48124164
17Lip pit (HP:0100267)3.40790496
18White forelock (HP:0002211)3.40526869
19Abnormality of renal resorption (HP:0011038)3.30707029
20Milia (HP:0001056)3.29153195
21Overgrowth (HP:0001548)3.28045618
22Sparse lateral eyebrow (HP:0005338)3.26658440
23Enlarged epiphyses (HP:0010580)3.19616434
24Abnormality of renal excretion (HP:0011036)3.18017488
25Morphological abnormality of the inner ear (HP:0011390)3.14733717
26Abnormality of calcium-phosphate metabolism (HP:0100530)3.11605953
27Vacuolated lymphocytes (HP:0001922)3.05634002
28Patchy hypopigmentation of hair (HP:0011365)3.01989858
29Blepharitis (HP:0000498)2.97329473
30Abnormality of the dental pulp (HP:0006479)2.94237381
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93911171
32Chronic bronchitis (HP:0004469)2.93176181
33Infantile muscular hypotonia (HP:0008947)2.92580891
34Hypoplasia of dental enamel (HP:0006297)2.90461573
35Gout (HP:0001997)2.89850258
36Nephritis (HP:0000123)2.89849355
37Hypoplasia of the iris (HP:0007676)2.88629465
38Subcapsular cataract (HP:0000523)2.88399084
39Abnormal hair laboratory examination (HP:0003328)2.81455767
40Axonal loss (HP:0003447)2.79127700
41Exostoses (HP:0100777)2.74670156
42Metaphyseal dysplasia (HP:0100255)2.72351780
43Oligomenorrhea (HP:0000876)2.71491232
44Hypokalemic alkalosis (HP:0001949)2.71151963
45Microretrognathia (HP:0000308)2.68352165
46Aortic aneurysm (HP:0004942)2.65739618
47Widely patent fontanelles and sutures (HP:0004492)2.65194109
48Tubulointerstitial fibrosis (HP:0005576)2.64725724
49Hyperkalemia (HP:0002153)2.62080171
50Stomach cancer (HP:0012126)2.56978909
51Hyperglycinuria (HP:0003108)2.55916767
52Abnormality of the renal medulla (HP:0100957)2.53754150
53Hamartoma of the eye (HP:0010568)2.51902992
54Hyperaldosteronism (HP:0000859)2.47947777
55Abnormal tarsal ossification (HP:0008369)2.46916274
56Abnormality of the axillary hair (HP:0100134)2.46904400
57Abnormality of secondary sexual hair (HP:0009888)2.46904400
58Long toe (HP:0010511)2.44763454
59Abnormality of renin-angiotensin system (HP:0000847)2.44587227
60Abnormality of nucleobase metabolism (HP:0010932)2.43935090
61Breast carcinoma (HP:0003002)2.42371530
62Abnormality of cochlea (HP:0000375)2.42115284
63Thin bony cortex (HP:0002753)2.38320573
64Interstitial pulmonary disease (HP:0006530)2.37476069
65Abnormality of dental color (HP:0011073)2.34896064
66Flat acetabular roof (HP:0003180)2.31805737
67Hypoplasia of the pons (HP:0012110)2.30080549
68Renal salt wasting (HP:0000127)2.28991965
69Premature skin wrinkling (HP:0100678)2.26410553
70Aortic dissection (HP:0002647)2.26058339
71Alopecia of scalp (HP:0002293)2.25218497
72Hypohidrosis (HP:0000966)2.23497862
73Ketoacidosis (HP:0001993)2.22729856
74Deep philtrum (HP:0002002)2.22350346
75Popliteal pterygium (HP:0009756)2.22233221
76Abnormality of the pons (HP:0007361)2.19087768
77Nail dystrophy (HP:0008404)2.17756528
78Tongue fasciculations (HP:0001308)2.16574419
79Severe Myopia (HP:0011003)2.16433307
80Germ cell neoplasia (HP:0100728)2.16402092
81Septate vagina (HP:0001153)2.16103918
82Asymmetry of the thorax (HP:0001555)2.15646945
83Premature loss of primary teeth (HP:0006323)2.15324802
84Ketosis (HP:0001946)2.13234027
85Abnormality of the parathyroid morphology (HP:0011766)2.12515948
86Tubulointerstitial abnormality (HP:0001969)2.12416241
87Congenital, generalized hypertrichosis (HP:0004540)2.12127499
88Pancreatic cysts (HP:0001737)2.11968379
89Stridor (HP:0010307)2.11817248
90Abnormality of the renal collecting system (HP:0004742)2.11172375
91Type II lissencephaly (HP:0007260)2.11010992
92Osteolytic defects of the hand bones (HP:0009699)2.09849543
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.09849543
94Glomerulosclerosis (HP:0000096)2.06518204
95Fragile nails (HP:0001808)2.06375196
96Renal tubular acidosis (HP:0001947)2.06072303
97Abnormality of chloride homeostasis (HP:0011422)2.05164127
98Facial shape deformation (HP:0011334)2.04987332
99Potter facies (HP:0002009)2.04987332
100Abnormality of the renal cortex (HP:0011035)2.04624904
101Epiphyseal stippling (HP:0010655)2.02581046
102Woolly hair (HP:0002224)2.02042125
103Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.01198389
104Macroorchidism (HP:0000053)2.00878390
105Shawl scrotum (HP:0000049)2.00776837
106Abnormality of the epiphysis of the femoral head (HP:0010574)2.00140042
107Abnormality of the femoral head (HP:0003368)1.99677512
108Hydronephrosis (HP:0000126)1.99344344
109Exotropia (HP:0000577)1.98703847
110Abnormality of nail color (HP:0100643)1.98394304
111Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97026806
112Hypoplastic scapulae (HP:0000882)1.97026806
113Plantar hyperkeratosis (HP:0007556)1.96978155
114Anterior segment dysgenesis (HP:0007700)1.93407804
115True hermaphroditism (HP:0010459)1.91581523
116Hypotrichosis (HP:0001006)1.91557687
117Syncope (HP:0001279)1.90519092
118Absent eyelashes (HP:0000561)1.89984553
119Nasolacrimal duct obstruction (HP:0000579)1.89208599
120Abnormality of the nasal septum (HP:0000419)1.88689869
121Aplasia of the musculature (HP:0100854)1.88379116
122Heterochromia iridis (HP:0001100)1.87402489
123Cystic liver disease (HP:0006706)1.86249610
124Hypothermia (HP:0002045)1.85861922
125Long foot (HP:0001833)1.85843395
126Corneal erosion (HP:0200020)1.85518594
127Abnormal epiphyseal ossification (HP:0010656)1.84809824
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83007106
129Abnormal auditory evoked potentials (HP:0006958)1.82066334
130Congenital stationary night blindness (HP:0007642)1.81663415
131Pruritus (HP:0000989)1.81403285
132Bone pain (HP:0002653)1.81013003
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80011561
134Astrocytoma (HP:0009592)1.79977549
135Abnormality of the astrocytes (HP:0100707)1.79977549
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.79737830
137Abnormal hemoglobin (HP:0011902)1.78949075
138Abnormality of glycine metabolism (HP:0010895)1.78926959
139Abnormality of serine family amino acid metabolism (HP:0010894)1.78926959
140Reduced antithrombin III activity (HP:0001976)1.78030706
141Tinnitus (HP:0000360)1.76950380
142Akinesia (HP:0002304)1.76535369
143Autoamputation (HP:0001218)1.75894904
144Ependymoma (HP:0002888)1.75602979
145Glioma (HP:0009733)1.75166374
146Tubular atrophy (HP:0000092)1.74450582
147Molar tooth sign on MRI (HP:0002419)1.74347116
148Abnormality of midbrain morphology (HP:0002418)1.74347116
149Abdominal distention (HP:0003270)1.73691480
150Testicular atrophy (HP:0000029)1.73401290
151Bronchitis (HP:0012387)1.73240268
152Lymphangioma (HP:0100764)1.73043167
153Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71571056
154Abnormality of femoral epiphyses (HP:0006499)1.71571056
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.71562547
156Absent/shortened dynein arms (HP:0200106)1.71562547
157Abnormality of the anterior chamber (HP:0000593)1.71504352
158Hyperphosphatemia (HP:0002905)1.70257031
159Vascular calcification (HP:0004934)1.70239542
160Cone-rod dystrophy (HP:0000548)1.69989667
161Clumsiness (HP:0002312)1.68773107
162Infertility (HP:0000789)1.68689849
163Polar cataract (HP:0010696)1.68425930
164Protuberant abdomen (HP:0001538)1.67891538
165Urethral obstruction (HP:0000796)1.67872335
166Chronic sinusitis (HP:0011109)1.67782555
167Abnormality of the epiphyses of the hand (HP:0005924)1.67242520
168Abnormality of proline metabolism (HP:0010907)1.67007311
169Hydroxyprolinuria (HP:0003080)1.67007311
170Abnormality of the distal phalanges of the toes (HP:0010182)1.66718059
171Hypoplastic ischia (HP:0003175)1.66404085
172Furrowed tongue (HP:0000221)1.65845856
173Mucopolysacchariduria (HP:0008155)1.65307719
174Urinary glycosaminoglycan excretion (HP:0003541)1.65307719
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64820896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK16.33192922
2CAMK1D4.08363480
3AKT33.66477014
4CAMK1G3.20590960
5LATS13.17993008
6PIK3CA2.58210155
7PDK22.41340650
8IRAK32.38914704
9NME22.32516607
10EPHA32.28239680
11EPHA22.20667572
12TESK12.15285565
13VRK22.12371397
14STK38L2.11812689
15MAP2K62.06151321
16EEF2K2.05214741
17PKN21.99751221
18FRK1.97219320
19EPHB11.92494940
20EIF2AK11.89167384
21ERN11.67995258
22PTK61.67359250
23STK391.63940059
24MYLK1.59066107
25RPS6KB21.56601883
26BCKDK1.54812738
27TESK21.53165667
28TRPM71.50375063
29MAPKAPK31.49837459
30MST41.48660755
31FER1.48068842
32OXSR11.47819235
33MAPK151.47346487
34MATK1.46815593
35MAP3K31.41957464
36ZAK1.39789825
37NLK1.39301409
38STK241.33814347
39PDGFRB1.31076600
40PDK41.27903606
41PDK31.27903606
42NUAK11.27300781
43ADRBK21.24619680
44BMPR1B1.19148778
45ILK1.13554535
46NEK61.10986448
47LIMK11.09354941
48ZAP701.09348060
49RIPK11.08378037
50TAOK31.04991946
51JAK31.03243817
52MAP3K141.02403496
53WNK31.02132580
54TRIB31.01697579
55PINK11.01651831
56BMX0.98264585
57SCYL20.94473118
58CDK120.93338025
59TGFBR20.90121922
60MAP3K20.89159516
61PRKAA20.89037403
62EIF2AK30.88660885
63WNK40.87197844
64TXK0.85881865
65STK30.84716954
66PIK3CG0.84495874
67TRIM280.84068607
68TNK20.83407031
69MUSK0.82576642
70IRAK40.82287523
71IRAK10.81854058
72MAP4K20.81152914
73EIF2AK20.80940766
74STK160.80747601
75STK380.80372712
76CHUK0.78622071
77INSRR0.78213275
78GRK50.76601416
79TSSK60.72170132
80BMPR20.70169637
81JAK10.69166323
82TNIK0.63491487
83PRKD10.59844622
84RPS6KA20.58446733
85PAK30.58139635
86CSF1R0.56920241
87TAF10.56314635
88SGK4940.55391092
89SGK2230.55391092
90RET0.54965164
91GRK60.54938034
92MST1R0.53789748
93ICK0.53646794
94DAPK20.53182952
95CAMK10.50899837
96MET0.50646984
97CDK70.49692165
98GRK10.48512199
99BTK0.47158493
100LRRK20.46896293
101CASK0.46243731
102MAP2K10.46203270
103TLK10.46052820
104CSNK1A10.45640432
105MAP3K120.43896502
106SGK20.43733551
107MTOR0.43516090
108ACVR1B0.42942531
109ERBB30.41768458
110MAP3K70.40305799
111IGF1R0.40239351
112GSK3A0.39341638
113TAOK10.39114376
114FGFR30.37888372
115MAP2K70.37608435
116NEK90.36532539
117JAK20.36491669
118EPHB20.36312182
119YES10.35824564
120PBK0.35532356
121HIPK20.35069204
122PRKD20.34914797
123PRKCE0.34228562
124CAMK2D0.34091639
125MAPKAPK50.33500594
126PRKCZ0.32422052
127MAPKAPK20.31737778
128PRKCI0.31266035
129VRK10.31156483
130CSNK1E0.31000678
131IKBKE0.30464064
132PTK20.29436573
133ERBB20.29257358
134MAPK120.29132161
135MAPK130.28594620
136IKBKB0.28318591
137TIE10.28093865
138PRKCD0.26665581
139RPS6KB10.26262484
140SGK30.25331933
141RPS6KL10.24879294
142RPS6KC10.24879294
143MAP2K20.24419976
144PRKAA10.24089987
145RPS6KA60.23506972
146TYK20.21145966
147PIM10.20472587

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000618.84744837
2Caffeine metabolism_Homo sapiens_hsa002328.42071925
3Galactose metabolism_Homo sapiens_hsa000523.26848093
4Protein export_Homo sapiens_hsa030602.32354056
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95942663
6Nitrogen metabolism_Homo sapiens_hsa009101.92424312
7Histidine metabolism_Homo sapiens_hsa003401.82292582
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73662223
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69242261
10N-Glycan biosynthesis_Homo sapiens_hsa005101.67807588
11Fatty acid metabolism_Homo sapiens_hsa012121.66036992
12Propanoate metabolism_Homo sapiens_hsa006401.52688020
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51672452
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44690600
15* Prolactin signaling pathway_Homo sapiens_hsa049171.43330202
16Linoleic acid metabolism_Homo sapiens_hsa005911.38902025
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38381218
18Sulfur metabolism_Homo sapiens_hsa009201.34749910
19Fat digestion and absorption_Homo sapiens_hsa049751.17950829
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05556907
21Pyruvate metabolism_Homo sapiens_hsa006201.04926346
22Ether lipid metabolism_Homo sapiens_hsa005651.03279173
23Vibrio cholerae infection_Homo sapiens_hsa051101.02666622
24Sulfur relay system_Homo sapiens_hsa041221.02498640
25Rheumatoid arthritis_Homo sapiens_hsa053230.97228346
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96476443
27Primary bile acid biosynthesis_Homo sapiens_hsa001200.95955614
28Fatty acid elongation_Homo sapiens_hsa000620.94842291
29Steroid biosynthesis_Homo sapiens_hsa001000.94134908
30Collecting duct acid secretion_Homo sapiens_hsa049660.91326685
31Mineral absorption_Homo sapiens_hsa049780.91006321
32Acute myeloid leukemia_Homo sapiens_hsa052210.90343315
33Adherens junction_Homo sapiens_hsa045200.88807741
34PPAR signaling pathway_Homo sapiens_hsa033200.88571620
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87168548
36Drug metabolism - other enzymes_Homo sapiens_hsa009830.85821412
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.83153489
38ABC transporters_Homo sapiens_hsa020100.81348782
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81224442
40Butanoate metabolism_Homo sapiens_hsa006500.80664159
41Phenylalanine metabolism_Homo sapiens_hsa003600.80478645
42Tryptophan metabolism_Homo sapiens_hsa003800.79664439
43Hepatitis C_Homo sapiens_hsa051600.79527302
44Glycerolipid metabolism_Homo sapiens_hsa005610.78986114
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77188658
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75363512
47Arginine and proline metabolism_Homo sapiens_hsa003300.74487835
48Tyrosine metabolism_Homo sapiens_hsa003500.73667778
49Lysosome_Homo sapiens_hsa041420.73537574
50Peroxisome_Homo sapiens_hsa041460.73515308
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73293626
52Tight junction_Homo sapiens_hsa045300.73184091
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70360043
54Phototransduction_Homo sapiens_hsa047440.69670990
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.69575732
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66138123
57ECM-receptor interaction_Homo sapiens_hsa045120.64843016
58Pancreatic cancer_Homo sapiens_hsa052120.63468565
59Toxoplasmosis_Homo sapiens_hsa051450.63340588
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63214598
61Taste transduction_Homo sapiens_hsa047420.62659328
62Hippo signaling pathway_Homo sapiens_hsa043900.62039931
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59686559
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58695197
65Endometrial cancer_Homo sapiens_hsa052130.57245717
66Sphingolipid metabolism_Homo sapiens_hsa006000.56644515
67Insulin resistance_Homo sapiens_hsa049310.54216970
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53958465
69AMPK signaling pathway_Homo sapiens_hsa041520.53494476
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.53412559
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52492259
72Ovarian steroidogenesis_Homo sapiens_hsa049130.52113300
73Amoebiasis_Homo sapiens_hsa051460.49770124
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49281810
75Vitamin digestion and absorption_Homo sapiens_hsa049770.49019912
76Measles_Homo sapiens_hsa051620.48584416
77Glutathione metabolism_Homo sapiens_hsa004800.48168343
78Prostate cancer_Homo sapiens_hsa052150.46911863
79Chronic myeloid leukemia_Homo sapiens_hsa052200.45576948
80Small cell lung cancer_Homo sapiens_hsa052220.45135032
81Metabolic pathways_Homo sapiens_hsa011000.44660538
82Phagosome_Homo sapiens_hsa041450.44566837
83Arachidonic acid metabolism_Homo sapiens_hsa005900.44534807
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44515245
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.44465161
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43436545
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.43030914
88Pancreatic secretion_Homo sapiens_hsa049720.41122273
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40282731
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38429445
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38033180
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.37614094
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36424563
94Salivary secretion_Homo sapiens_hsa049700.36357987
95Selenocompound metabolism_Homo sapiens_hsa004500.36204048
96Fatty acid degradation_Homo sapiens_hsa000710.35237089
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.35149537
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34686806
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.34545610
100Melanoma_Homo sapiens_hsa052180.34127602
101Hepatitis B_Homo sapiens_hsa051610.33688392
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33433338
103Influenza A_Homo sapiens_hsa051640.32262759
104Basal cell carcinoma_Homo sapiens_hsa052170.31412198
105Focal adhesion_Homo sapiens_hsa045100.30916247
106Other glycan degradation_Homo sapiens_hsa005110.30874724
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30244220
108FoxO signaling pathway_Homo sapiens_hsa040680.29859694
109Gastric acid secretion_Homo sapiens_hsa049710.29691814
110TNF signaling pathway_Homo sapiens_hsa046680.28769790
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28465412
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28233011
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27581377
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26594927
115Chemical carcinogenesis_Homo sapiens_hsa052040.26341827
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26283313
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25744471
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25737582
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.25345045
120Oxidative phosphorylation_Homo sapiens_hsa001900.24296909
121Leishmaniasis_Homo sapiens_hsa051400.24183927
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23668227
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23663465
124Notch signaling pathway_Homo sapiens_hsa043300.23557351
125Lysine degradation_Homo sapiens_hsa003100.23524005
126ErbB signaling pathway_Homo sapiens_hsa040120.21326329
127Pentose phosphate pathway_Homo sapiens_hsa000300.20543518
128Circadian rhythm_Homo sapiens_hsa047100.20151704
129Bladder cancer_Homo sapiens_hsa052190.19969103
130Purine metabolism_Homo sapiens_hsa002300.18964742
131beta-Alanine metabolism_Homo sapiens_hsa004100.18590054
132Tuberculosis_Homo sapiens_hsa051520.18541922
133Proteoglycans in cancer_Homo sapiens_hsa052050.18465832
134Legionellosis_Homo sapiens_hsa051340.18455828
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18270486
136Colorectal cancer_Homo sapiens_hsa052100.17580498
137Pathways in cancer_Homo sapiens_hsa052000.17402494
138Insulin signaling pathway_Homo sapiens_hsa049100.16514086
139Regulation of autophagy_Homo sapiens_hsa041400.14555493
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14256021
141Olfactory transduction_Homo sapiens_hsa047400.13592445
142One carbon pool by folate_Homo sapiens_hsa006700.11658965
143Proteasome_Homo sapiens_hsa030500.09437098
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.09377710
145Thyroid hormone synthesis_Homo sapiens_hsa049180.08230958
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.08110444
147Insulin secretion_Homo sapiens_hsa049110.06638135
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05717591
149Basal transcription factors_Homo sapiens_hsa030220.05584452

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