ELFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.78319458
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14775236
3synaptic vesicle maturation (GO:0016188)5.83789486
4locomotory exploration behavior (GO:0035641)5.50991781
5regulation of rhodopsin mediated signaling pathway (GO:0022400)5.44214160
6retinal cone cell development (GO:0046549)5.35869368
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28588296
8rhodopsin mediated signaling pathway (GO:0016056)5.27570332
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22034827
10nucleobase catabolic process (GO:0046113)5.18868851
11vocalization behavior (GO:0071625)5.18410578
12synaptic vesicle exocytosis (GO:0016079)4.87745691
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.84866906
14regulation of synaptic vesicle exocytosis (GO:2000300)4.74150926
15glutamate secretion (GO:0014047)4.69199207
16protein localization to synapse (GO:0035418)4.65731003
17axonal fasciculation (GO:0007413)4.56773419
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.50956508
19regulation of glutamate receptor signaling pathway (GO:1900449)4.36651002
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.35331755
21cell migration in hindbrain (GO:0021535)4.31737012
22behavioral response to nicotine (GO:0035095)4.27526964
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.25010666
24exploration behavior (GO:0035640)4.23903191
25regulation of synaptic vesicle transport (GO:1902803)4.19295177
26neurotransmitter secretion (GO:0007269)4.11543137
27cell proliferation in forebrain (GO:0021846)4.08656506
28neuron cell-cell adhesion (GO:0007158)4.05335825
29cellular potassium ion homeostasis (GO:0030007)4.03125429
30neuron projection extension involved in neuron projection guidance (GO:1902284)4.02909529
31axon extension involved in axon guidance (GO:0048846)4.02909529
32photoreceptor cell development (GO:0042461)3.98346154
33detection of light stimulus involved in visual perception (GO:0050908)3.96075794
34detection of light stimulus involved in sensory perception (GO:0050962)3.96075794
35layer formation in cerebral cortex (GO:0021819)3.89714080
36regulation of neuronal synaptic plasticity (GO:0048168)3.81068878
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.80910390
38presynaptic membrane organization (GO:0097090)3.80406902
39eye photoreceptor cell development (GO:0042462)3.79499417
40establishment of mitochondrion localization (GO:0051654)3.77132910
41photoreceptor cell maintenance (GO:0045494)3.74827326
42sodium ion export (GO:0071436)3.73833311
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.71184459
44retinal ganglion cell axon guidance (GO:0031290)3.68463664
45proline transport (GO:0015824)3.67719087
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67467280
47presynaptic membrane assembly (GO:0097105)3.66075930
48axon extension (GO:0048675)3.64976719
49camera-type eye morphogenesis (GO:0048593)3.60044187
50synaptic transmission, glutamatergic (GO:0035249)3.59683355
51positive regulation of neurotransmitter transport (GO:0051590)3.56515688
52dendritic spine morphogenesis (GO:0060997)3.55199703
53substrate-independent telencephalic tangential migration (GO:0021826)3.54543284
54substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.54543284
55neurotransmitter transport (GO:0006836)3.51360573
56positive regulation of membrane potential (GO:0045838)3.49095988
57positive regulation of gastrulation (GO:2000543)3.48324499
58short-term memory (GO:0007614)3.47786896
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38507608
60neuron-neuron synaptic transmission (GO:0007270)3.38496253
61transmission of nerve impulse (GO:0019226)3.36588472
62membrane hyperpolarization (GO:0060081)3.35824147
63regulation of neurotransmitter secretion (GO:0046928)3.32601388
64positive regulation of guanylate cyclase activity (GO:0031284)3.32382025
65head development (GO:0060322)3.31705039
66phototransduction (GO:0007602)3.30677194
67regulation of synapse structural plasticity (GO:0051823)3.29984683
68neuromuscular process controlling posture (GO:0050884)3.28012379
69regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25472778
70gamma-aminobutyric acid transport (GO:0015812)3.25440432
71neuronal action potential propagation (GO:0019227)3.24450347
72mitochondrion transport along microtubule (GO:0047497)3.22882607
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.22882607
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22870705
75regulation of postsynaptic membrane potential (GO:0060078)3.21581660
76negative regulation of axon guidance (GO:1902668)3.21472450
77spinal cord association neuron differentiation (GO:0021527)3.21330872
78detection of light stimulus (GO:0009583)3.20977204
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20890298
80cell communication by electrical coupling (GO:0010644)3.20448008
81response to auditory stimulus (GO:0010996)3.19947135
82innervation (GO:0060384)3.19801698
83protein-chromophore linkage (GO:0018298)3.19118965
84glutamate receptor signaling pathway (GO:0007215)3.18363870
85spinal cord development (GO:0021510)3.17463898
86long-term memory (GO:0007616)3.16728545
87neurotransmitter-gated ion channel clustering (GO:0072578)3.16251173
88glycine transport (GO:0015816)3.15170052
89postsynaptic membrane organization (GO:0001941)3.14656361
90startle response (GO:0001964)3.13710161
91regulation of clathrin-mediated endocytosis (GO:2000369)3.13163079
92detection of visible light (GO:0009584)3.12333387
93activation of protein kinase A activity (GO:0034199)3.11203575
94regulation of voltage-gated calcium channel activity (GO:1901385)3.09161678
95positive regulation of synapse assembly (GO:0051965)3.08619331
96synaptic vesicle endocytosis (GO:0048488)3.08083406
97phototransduction, visible light (GO:0007603)3.07394273
98retinal rod cell development (GO:0046548)3.05640937
99regulation of vesicle fusion (GO:0031338)3.05119907
100regulation of neurotransmitter transport (GO:0051588)3.03736075
101regulation of neurotransmitter levels (GO:0001505)3.03542797
102response to pheromone (GO:0019236)3.03474229
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02223340
104calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98958308
105negative regulation of axon extension involved in axon guidance (GO:0048843)2.98501202
106cerebellar Purkinje cell differentiation (GO:0021702)2.98002837
107membrane depolarization during action potential (GO:0086010)2.97744539
108neuron recognition (GO:0008038)2.97555076
109negative regulation of catenin import into nucleus (GO:0035414)2.97114930
110neuronal stem cell maintenance (GO:0097150)2.96594614
111cerebral cortex radially oriented cell migration (GO:0021799)2.95990830
112chemosensory behavior (GO:0007635)2.95356199
113auditory behavior (GO:0031223)2.94950825
114positive regulation of synapse maturation (GO:0090129)2.94372263
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93198913
116regulation of guanylate cyclase activity (GO:0031282)2.92700584
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92223692
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90442577
119regulation of synaptic plasticity (GO:0048167)2.90235029
120regulation of axon guidance (GO:1902667)2.89740070
121limb development (GO:0060173)2.88852507
122appendage development (GO:0048736)2.88852507
123positive regulation of neurotransmitter secretion (GO:0001956)2.88275587
124intraspecies interaction between organisms (GO:0051703)2.87632924
125social behavior (GO:0035176)2.87632924
126response to histamine (GO:0034776)2.86042483
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.85856523
128neuron projection extension (GO:1990138)2.85621353
129calcium ion-dependent exocytosis (GO:0017156)2.85579182
130olfactory bulb development (GO:0021772)2.84636676
131pattern specification involved in kidney development (GO:0061004)2.84504823
132vesicle transport along microtubule (GO:0047496)2.83152870
133neuromuscular process controlling balance (GO:0050885)2.83103023
134dendrite morphogenesis (GO:0048813)2.83091598
135central nervous system projection neuron axonogenesis (GO:0021952)2.81472941
136long-term synaptic potentiation (GO:0060291)2.81281586
137synapse assembly (GO:0007416)2.79647495
138visual perception (GO:0007601)2.78879163
139membrane depolarization (GO:0051899)2.78268882
140neuronal ion channel clustering (GO:0045161)2.77989587
141potassium ion homeostasis (GO:0055075)2.77424225
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76382278
143forebrain neuron differentiation (GO:0021879)2.72741014
144regulation of axon extension involved in axon guidance (GO:0048841)2.71726338
145cardiovascular system development (GO:0072358)2.71719169
146adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66156182
147ganglion development (GO:0061548)2.65791753
148positive regulation of neuroblast proliferation (GO:0002052)2.65195330
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58369435
150ephrin receptor signaling pathway (GO:0048013)2.57564169
151cell-cell junction maintenance (GO:0045217)2.57009055
152somite development (GO:0061053)2.56731676
153synaptic transmission, cholinergic (GO:0007271)2.56661076
154lens fiber cell development (GO:0070307)2.55219477
155dendrite development (GO:0016358)2.53291628
156establishment of planar polarity (GO:0001736)2.50560250
157establishment of tissue polarity (GO:0007164)2.50560250
158negative regulation of oligodendrocyte differentiation (GO:0048715)2.49324503
159neuron migration (GO:0001764)2.46665540
160cranial nerve morphogenesis (GO:0021602)2.46416553
161urogenital system development (GO:0001655)2.44999630
162viral transcription (GO:0019083)2.43978796
163body morphogenesis (GO:0010171)2.43823724
164adult walking behavior (GO:0007628)2.43805300
165mechanosensory behavior (GO:0007638)2.42583174
166establishment of nucleus localization (GO:0040023)2.38898470
167convergent extension (GO:0060026)2.38698043
168hippocampus development (GO:0021766)2.36078568
169negative chemotaxis (GO:0050919)2.35095319
170central nervous system myelination (GO:0022010)2.35055262
171axon ensheathment in central nervous system (GO:0032291)2.35055262
172Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.33972450
173behavioral response to ethanol (GO:0048149)2.33929529
174regulation of microtubule-based movement (GO:0060632)2.32660151
175translational termination (GO:0006415)2.31737840
176regulation of synapse assembly (GO:0051963)2.29777191
177ribosomal small subunit assembly (GO:0000028)2.29758217
178neurofilament cytoskeleton organization (GO:0060052)2.29486404
179apical protein localization (GO:0045176)2.28271979

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63003188
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.71333204
3GBX2_23144817_ChIP-Seq_PC3_Human3.30480636
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80606686
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80527766
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74633930
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71984015
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63335375
9REST_21632747_ChIP-Seq_MESCs_Mouse2.57436655
10DROSHA_22980978_ChIP-Seq_HELA_Human2.51021514
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48329270
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47966563
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47966563
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44628508
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41659242
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36632175
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33861395
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30531073
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24341511
20* EZH2_27304074_Chip-Seq_ESCs_Mouse2.22266778
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18501756
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18469679
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.16469319
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.10375540
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.07972237
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.01912975
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94702897
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.92394918
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85521766
30AR_21572438_ChIP-Seq_LNCaP_Human1.82670521
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81242412
32OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.78580650
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62744155
34SMAD4_21799915_ChIP-Seq_A2780_Human1.57111471
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56723540
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56529094
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55648028
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53315349
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49742851
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38540535
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38238048
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.37959147
43* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35095470
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34549332
45* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32809936
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31303536
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30148697
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29110094
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27995845
50ZNF274_21170338_ChIP-Seq_K562_Hela1.26987503
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23831565
52AR_19668381_ChIP-Seq_PC3_Human1.23545878
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23181409
54P300_19829295_ChIP-Seq_ESCs_Human1.19997664
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18100340
56STAT3_23295773_ChIP-Seq_U87_Human1.17970056
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17477482
58* CBX2_27304074_Chip-Seq_ESCs_Mouse1.17061974
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.16766962
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.16570412
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15121216
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14690196
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14649249
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.14176031
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.13536232
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.13308750
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13112376
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12770047
69* KDM2B_26808549_Chip-Seq_K562_Human1.12072006
70RNF2_27304074_Chip-Seq_NSC_Mouse1.11137021
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10977589
72AHR_22903824_ChIP-Seq_MCF-7_Human1.10066858
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09981631
74TAF15_26573619_Chip-Seq_HEK293_Human1.09760954
75AR_25329375_ChIP-Seq_VCAP_Human1.09574617
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09034635
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08515453
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07840804
79* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07795637
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.07499627
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.07254301
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.07226131
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06329757
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06078313
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.05398636
86TCF4_23295773_ChIP-Seq_U87_Human1.04862205
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.03178215
88IGF1R_20145208_ChIP-Seq_DFB_Human1.02859358
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02629539
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02404520
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01922422
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98659503
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98367093
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97777218
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97647313
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97611622
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97248269
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97216247
99* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97178895
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.97056024
101* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96439540
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96180921
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96180921
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95956506
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.95807561
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95391575
107* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94291370
108BCAT_22108803_ChIP-Seq_LS180_Human0.94157259
109* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93918434
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93738063
111VDR_22108803_ChIP-Seq_LS180_Human0.92810676
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.90867027
113CTCF_27219007_Chip-Seq_Bcells_Human0.90802953
114* RUNX2_22187159_ChIP-Seq_PCA_Human0.89645452
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89430024
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89244614
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.87785468
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.86858914
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86089030
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85402644
121CBP_20019798_ChIP-Seq_JUKART_Human0.85402644
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85398366
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84189154
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83599177
125SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83226200
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80223566
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79592696
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79559587
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79286335
130IRF1_19129219_ChIP-ChIP_H3396_Human0.79051151
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77261447
132* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75815156
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74809937
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74070115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.41190316
2MP0005551_abnormal_eye_electrophysiolog4.24798468
3MP0006292_abnormal_olfactory_placode3.76106672
4MP0003635_abnormal_synaptic_transmissio3.54921369
5MP0003880_abnormal_central_pattern3.48648061
6MP0005423_abnormal_somatic_nervous3.33839655
7MP0004270_analgesia3.25749801
8MP0003011_delayed_dark_adaptation3.21393032
9MP0009745_abnormal_behavioral_response2.86182449
10MP0002063_abnormal_learning/memory/cond2.83125391
11MP0001968_abnormal_touch/_nociception2.79317747
12MP0005253_abnormal_eye_physiology2.74743014
13MP0002064_seizures2.67936385
14MP0009046_muscle_twitch2.66123344
15MP0009379_abnormal_foot_pigmentation2.52350426
16MP0006072_abnormal_retinal_apoptosis2.50805695
17MP0002572_abnormal_emotion/affect_behav2.44761745
18MP0001486_abnormal_startle_reflex2.43749865
19MP0002734_abnormal_mechanical_nocicepti2.42041084
20MP0010030_abnormal_orbit_morphology2.30298073
21MP0002735_abnormal_chemical_nociception2.27193771
22MP0002272_abnormal_nervous_system2.25902675
23MP0002736_abnormal_nociception_after2.09003561
24MP0009780_abnormal_chondrocyte_physiolo2.05155899
25MP0000049_abnormal_middle_ear1.95975712
26MP0004858_abnormal_nervous_system1.94182359
27MP0003121_genomic_imprinting1.92888729
28MP0003123_paternal_imprinting1.87659066
29MP0006276_abnormal_autonomic_nervous1.84252668
30MP0001293_anophthalmia1.83954319
31MP0000566_synostosis1.83608792
32MP0002822_catalepsy1.82067629
33MP0001501_abnormal_sleep_pattern1.81686977
34MP0005257_abnormal_intraocular_pressure1.78363509
35MP0002229_neurodegeneration1.74175683
36MP0005646_abnormal_pituitary_gland1.73315582
37MP0001984_abnormal_olfaction1.70852095
38MP0002067_abnormal_sensory_capabilities1.69887614
39MP0002882_abnormal_neuron_morphology1.69779167
40MP0004133_heterotaxia1.68196064
41MP0003942_abnormal_urinary_system1.67925331
42MP0001970_abnormal_pain_threshold1.67637367
43MP0002733_abnormal_thermal_nociception1.67514278
44MP0002557_abnormal_social/conspecific_i1.63859076
45MP0004885_abnormal_endolymph1.63853552
46MP0009053_abnormal_anal_canal1.63846484
47MP0002184_abnormal_innervation1.63648015
48MP0003136_yellow_coat_color1.62885834
49MP0005195_abnormal_posterior_eye1.61973172
50MP0002090_abnormal_vision1.61702583
51MP0001502_abnormal_circadian_rhythm1.60949347
52MP0004811_abnormal_neuron_physiology1.60507524
53MP0005410_abnormal_fertilization1.60122625
54MP0001440_abnormal_grooming_behavior1.59551095
55MP0008789_abnormal_olfactory_epithelium1.55616989
56MP0008569_lethality_at_weaning1.53538893
57MP0000778_abnormal_nervous_system1.52309093
58MP0005645_abnormal_hypothalamus_physiol1.49050354
59MP0002938_white_spotting1.41309368
60MP0003879_abnormal_hair_cell1.40983521
61MP0002909_abnormal_adrenal_gland1.40719762
62MP0005386_behavior/neurological_phenoty1.35744779
63MP0004924_abnormal_behavior1.35744779
64MP0002752_abnormal_somatic_nervous1.35656094
65MP0000026_abnormal_inner_ear1.33480039
66MP0003890_abnormal_embryonic-extraembry1.31902227
67MP0000955_abnormal_spinal_cord1.30846857
68MP0003938_abnormal_ear_development1.30381003
69MP0004233_abnormal_muscle_weight1.28631956
70MP0003329_amyloid_beta_deposits1.28313367
71MP0001286_abnormal_eye_development1.27266488
72MP0002233_abnormal_nose_morphology1.25840349
73MP0010386_abnormal_urinary_bladder1.24890682
74MP0002249_abnormal_larynx_morphology1.24554065
75MP0003385_abnormal_body_wall1.24037657
76MP0003119_abnormal_digestive_system1.23912847
77MP0002697_abnormal_eye_size1.23708326
78MP0002066_abnormal_motor_capabilities/c1.21862118
79MP0002653_abnormal_ependyma_morphology1.20549571
80MP0005377_hearing/vestibular/ear_phenot1.20389129
81MP0003878_abnormal_ear_physiology1.20389129
82MP0002638_abnormal_pupillary_reflex1.19390165
83MP0003122_maternal_imprinting1.17565444
84MP0001177_atelectasis1.16916587
85MP0003755_abnormal_palate_morphology1.16854400
86MP0001485_abnormal_pinna_reflex1.15394950
87MP0003937_abnormal_limbs/digits/tail_de1.12994228
88MP0001324_abnormal_eye_pigmentation1.12704609
89MP0003787_abnormal_imprinting1.12219258
90MP0005391_vision/eye_phenotype1.11647208
91MP0002837_dystrophic_cardiac_calcinosis1.11540545
92MP0000569_abnormal_digit_pigmentation1.11223871
93MP0009250_abnormal_appendicular_skeleto1.10283199
94MP0002102_abnormal_ear_morphology1.09743161
95MP0000537_abnormal_urethra_morphology1.07473051
96MP0005503_abnormal_tendon_morphology1.06232335
97MP0002116_abnormal_craniofacial_bone1.04320529
98MP0002092_abnormal_eye_morphology1.04188308
99MP0002751_abnormal_autonomic_nervous1.03167541
100MP0005248_abnormal_Harderian_gland1.02832337
101MP0002152_abnormal_brain_morphology1.01917476
102MP0000428_abnormal_craniofacial_morphol1.01018976
103MP0005623_abnormal_meninges_morphology0.98087542
104MP0001529_abnormal_vocalization0.97550169
105MP0005499_abnormal_olfactory_system0.97423985
106MP0005394_taste/olfaction_phenotype0.97423985
107MP0003634_abnormal_glial_cell0.97374943
108MP0009384_cardiac_valve_regurgitation0.96533128
109MP0001905_abnormal_dopamine_level0.95278341
110MP0000631_abnormal_neuroendocrine_gland0.95036471
111MP0003633_abnormal_nervous_system0.94330376
112MP0001188_hyperpigmentation0.93311311
113MP0004742_abnormal_vestibular_system0.92992021
114MP0002234_abnormal_pharynx_morphology0.92703329
115MP0001963_abnormal_hearing_physiology0.91668912
116MP0001986_abnormal_taste_sensitivity0.91551017
117MP0004142_abnormal_muscle_tone0.91025038
118MP0008961_abnormal_basal_metabolism0.89473173
119MP0002081_perinatal_lethality0.86692644
120MP0004043_abnormal_pH_regulation0.82292113
121MP0003698_abnormal_male_reproductive0.81805987
122MP0001299_abnormal_eye_distance/0.80819767
123MP0003631_nervous_system_phenotype0.80075303
124MP0000534_abnormal_ureter_morphology0.76273635
125MP0008872_abnormal_physiological_respon0.75969642
126MP0000751_myopathy0.75814166
127MP0002069_abnormal_eating/drinking_beha0.75543984
128MP0004085_abnormal_heartbeat0.70822341
129MP0008004_abnormal_stomach_pH0.67209368
130MP0000681_abnormal_thyroid_gland0.66042340
131MP0000013_abnormal_adipose_tissue0.60927636
132MP0001664_abnormal_digestion0.58386374
133MP0003172_abnormal_lysosome_physiology0.58247780
134MP0003632_abnormal_nervous_system0.57276656
135MP0001943_abnormal_respiration0.56868021
136MP0005187_abnormal_penis_morphology0.56515743
137MP0003045_fibrosis0.56408044
138MP0003283_abnormal_digestive_organ0.55568961
139MP0008877_abnormal_DNA_methylation0.55102622
140MP0003861_abnormal_nervous_system0.54313193
141MP0008874_decreased_physiological_sensi0.51606183
142MP0005535_abnormal_body_temperature0.50069458

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.79783386
2Dyschromatopsia (HP:0007641)6.08852186
3Bony spicule pigmentary retinopathy (HP:0007737)6.03579716
4Central scotoma (HP:0000603)5.66160609
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.26093292
6Abnormality of macular pigmentation (HP:0008002)5.19315709
7Myokymia (HP:0002411)5.14302254
8Focal motor seizures (HP:0011153)4.99421693
9Abnormal rod and cone electroretinograms (HP:0008323)4.89616027
10Scotoma (HP:0000575)4.89387315
11Pigmentary retinal degeneration (HP:0001146)4.09109668
12Chorioretinal atrophy (HP:0000533)4.07784342
13Focal seizures (HP:0007359)3.77760371
14Visual hallucinations (HP:0002367)3.76125558
15Attenuation of retinal blood vessels (HP:0007843)3.73235463
16Decreased central vision (HP:0007663)3.71485051
17Progressive cerebellar ataxia (HP:0002073)3.69819368
18Abolished electroretinogram (ERG) (HP:0000550)3.62527176
19Epileptic encephalopathy (HP:0200134)3.57537524
20Pendular nystagmus (HP:0012043)3.56043748
21Febrile seizures (HP:0002373)3.55798705
22Posterior subcapsular cataract (HP:0007787)3.44528293
23Choroideremia (HP:0001139)3.37547817
24Type II diabetes mellitus (HP:0005978)3.26647310
25Photophobia (HP:0000613)3.19104009
26Septo-optic dysplasia (HP:0100842)3.14280370
27Action tremor (HP:0002345)3.10533340
28Supranuclear gaze palsy (HP:0000605)3.03762939
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96540047
30Short 4th metacarpal (HP:0010044)2.96540047
31Abnormality of the 4th metacarpal (HP:0010012)2.81504695
32Severe visual impairment (HP:0001141)2.81300547
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.73340386
34Absent/shortened dynein arms (HP:0200106)2.73340386
35Macular degeneration (HP:0000608)2.73161593
36Genetic anticipation (HP:0003743)2.71787443
37Rib fusion (HP:0000902)2.71431819
38Dysdiadochokinesis (HP:0002075)2.69142765
39Ankle clonus (HP:0011448)2.67332107
40Anophthalmia (HP:0000528)2.64848593
41Atonic seizures (HP:0010819)2.61726593
42Postural instability (HP:0002172)2.58326632
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57317300
44Hepatoblastoma (HP:0002884)2.55111994
45Abnormality of the aortic arch (HP:0012303)2.53662992
46Urinary bladder sphincter dysfunction (HP:0002839)2.53555374
47Truncal ataxia (HP:0002078)2.52346911
48Vitreoretinal degeneration (HP:0000655)2.52228479
49Generalized tonic-clonic seizures (HP:0002069)2.47533892
50Depression (HP:0000716)2.44780717
51Retinitis pigmentosa (HP:0000510)2.43180158
52High anterior hairline (HP:0009890)2.42060560
53Absence seizures (HP:0002121)2.41874205
54Constricted visual fields (HP:0001133)2.39106995
55Morphological abnormality of the middle ear (HP:0008609)2.37606668
56Broad-based gait (HP:0002136)2.34391209
57Renovascular hypertension (HP:0100817)2.31630406
58Nephronophthisis (HP:0000090)2.31597395
59Optic nerve hypoplasia (HP:0000609)2.30896942
60Gaze-evoked nystagmus (HP:0000640)2.30359305
61Subcapsular cataract (HP:0000523)2.27508314
62Impaired vibration sensation in the lower limbs (HP:0002166)2.26214477
63Mutism (HP:0002300)2.23670502
64Pachygyria (HP:0001302)2.23152573
65Gait imbalance (HP:0002141)2.22210245
66Increased corneal curvature (HP:0100692)2.22107667
67Keratoconus (HP:0000563)2.22107667
68Pancreatic fibrosis (HP:0100732)2.21500672
69Polyphagia (HP:0002591)2.21093970
70Retinal atrophy (HP:0001105)2.19939739
71Chronic hepatic failure (HP:0100626)2.18396068
72Anxiety (HP:0000739)2.18197928
73Hyperventilation (HP:0002883)2.18131963
74Cone-rod dystrophy (HP:0000548)2.15262772
75Abnormality of the diencephalon (HP:0010662)2.13173348
76Abnormal number of incisors (HP:0011064)2.12462467
77Renal duplication (HP:0000075)2.12262913
78Dialeptic seizures (HP:0011146)2.12107529
79Oligodactyly (HP:0012165)2.11529693
80Partial duplication of thumb phalanx (HP:0009944)2.11242593
81Molar tooth sign on MRI (HP:0002419)2.10229542
82Abnormality of midbrain morphology (HP:0002418)2.10229542
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07258380
84Oligodactyly (hands) (HP:0001180)2.06944309
85Partial duplication of the phalanx of hand (HP:0009999)2.03847939
86Neonatal short-limb short stature (HP:0008921)2.03394415
87Cutaneous finger syndactyly (HP:0010554)2.02178941
88Elfin facies (HP:0004428)2.01943986
89Turricephaly (HP:0000262)2.01609630
90Agitation (HP:0000713)2.00927354
91Absent speech (HP:0001344)1.99745737
92Abnormal eating behavior (HP:0100738)1.98532223
93Poor eye contact (HP:0000817)1.98484619
94Abnormality of the lower motor neuron (HP:0002366)1.98476922
95Megalencephaly (HP:0001355)1.97555287
96Intestinal atresia (HP:0011100)1.96136465
97Excessive salivation (HP:0003781)1.95061771
98Drooling (HP:0002307)1.95061771
99Cutaneous syndactyly (HP:0012725)1.94850746
100Congenital primary aphakia (HP:0007707)1.93787961
101Dysmetria (HP:0001310)1.93050985
102Broad metatarsal (HP:0001783)1.92688797
103Limb dystonia (HP:0002451)1.91193886
104Pheochromocytoma (HP:0002666)1.91034962
105Nephrogenic diabetes insipidus (HP:0009806)1.90412983
106Urinary urgency (HP:0000012)1.89561852
107Bradykinesia (HP:0002067)1.89516925
108Absent septum pellucidum (HP:0001331)1.88631741
109Genital tract atresia (HP:0001827)1.88441094
110Medial flaring of the eyebrow (HP:0010747)1.88412664
111Torticollis (HP:0000473)1.87541286
112Anencephaly (HP:0002323)1.86618513
113Abnormal social behavior (HP:0012433)1.86337069
114Impaired social interactions (HP:0000735)1.86337069
115Occipital encephalocele (HP:0002085)1.84539885
116Ventricular fibrillation (HP:0001663)1.84393838
117Adrenal hypoplasia (HP:0000835)1.83956249
118Shawl scrotum (HP:0000049)1.83630725
119Bladder diverticulum (HP:0000015)1.82537829
120Horizontal nystagmus (HP:0000666)1.82389089
121Abnormality of abdominal situs (HP:0011620)1.82085165
122Abdominal situs inversus (HP:0003363)1.82085165
123Abnormal respiratory epithelium morphology (HP:0012253)1.81497545
124Abnormal respiratory motile cilium morphology (HP:0005938)1.81497545
125Hyperglycinemia (HP:0002154)1.81291319
126Spastic gait (HP:0002064)1.80855952
127Broad phalanges of the hand (HP:0009768)1.80567497
128Aplasia/Hypoplasia of the brainstem (HP:0007362)1.79882515
129Hypoplasia of the brainstem (HP:0002365)1.79882515
130Broad finger (HP:0001500)1.79700609
131True hermaphroditism (HP:0010459)1.79564333
132Broad long bones (HP:0005622)1.79488668
133Abnormality of the renal medulla (HP:0100957)1.78891745
134Abnormality of the intervertebral disk (HP:0005108)1.78715392
135Scanning speech (HP:0002168)1.77794721
136Reticulocytopenia (HP:0001896)1.77072941
137Overriding aorta (HP:0002623)1.77043146
138Papilledema (HP:0001085)1.76875780
139Impaired smooth pursuit (HP:0007772)1.76654642
140Cortical dysplasia (HP:0002539)1.76613910
141Sleep apnea (HP:0010535)1.76539908
142Abnormality of dentin (HP:0010299)1.76362743
143Hypoventilation (HP:0002791)1.76120500
144Coronal craniosynostosis (HP:0004440)1.76042354
145Spastic tetraplegia (HP:0002510)1.75080079
146Hypoplasia of the ulna (HP:0003022)1.74538470
147Hemiplegia (HP:0002301)1.74408141
148Maternal diabetes (HP:0009800)1.74267536
149Abnormal pancreas size (HP:0012094)1.74209085
150Amblyopia (HP:0000646)1.74085537
151Sclerocornea (HP:0000647)1.73993659
152Broad phalanx (HP:0006009)1.73504616
153Aplasia involving bones of the extremities (HP:0009825)1.71788670
154Aplasia involving bones of the upper limbs (HP:0009823)1.71788670
155Aplasia of the phalanges of the hand (HP:0009802)1.71788670
156Lower limb muscle weakness (HP:0007340)1.71724763
157Abnormality of cells of the erythroid lineage (HP:0012130)1.70647406
158Synostosis of carpal bones (HP:0005048)1.70514737
159Fetal akinesia sequence (HP:0001989)1.70215314
160Fibular hypoplasia (HP:0003038)1.68931203
161Renal dysplasia (HP:0000110)1.68834677
162Supernumerary spleens (HP:0009799)1.68684268
163Hemiparesis (HP:0001269)1.68608574
164Bowel diverticulosis (HP:0005222)1.68036742
165Progressive visual loss (HP:0000529)1.67213796
166Postaxial hand polydactyly (HP:0001162)1.67180779
167Congenital sensorineural hearing impairment (HP:0008527)1.66800560
168Broad thumb (HP:0011304)1.66606533
169Specific learning disability (HP:0001328)1.66504891
170Intention tremor (HP:0002080)1.65736370
171Vaginal atresia (HP:0000148)1.65248067
172Wide anterior fontanel (HP:0000260)1.65213046
173Abnormal EKG (HP:0003115)1.64760353
174Abnormality of ocular smooth pursuit (HP:0000617)1.64680589
175Poor coordination (HP:0002370)1.64651148
176Renal hypoplasia (HP:0000089)1.64095120
177Focal dystonia (HP:0004373)1.64085044
178Insomnia (HP:0100785)1.63880297
179Abnormal respiratory motile cilium physiology (HP:0012261)1.63833604
180Abnormality of the labia minora (HP:0012880)1.62688266
181Hypoplastic pelvis (HP:0008839)1.62227448
182Hemivertebrae (HP:0002937)1.62133245
183Soft skin (HP:0000977)1.62075231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.00673315
2EPHB23.73913788
3PRKD33.26768372
4MAP3K93.26143277
5MARK13.02895835
6MAP3K42.91090839
7EPHA42.87671748
8MINK12.77668869
9DYRK22.72147684
10MAP2K72.39773457
11PAK62.21757153
12STK382.21683885
13NTRK22.03997084
14MAP3K121.95525730
15LMTK21.83014067
16BCR1.79559705
17MAP2K41.78337292
18GRK11.77393826
19EPHA31.77156560
20NTRK11.76590028
21DAPK21.73620393
22CAMKK11.71693976
23SIK21.55047979
24DYRK31.53058662
25DYRK1B1.48704522
26KSR21.48014036
27CDK51.46414941
28LATS21.41143609
29CASK1.34923537
30PINK11.33107368
31MAPK131.31758896
32TNIK1.30841778
33GRK51.30205074
34SGK2231.23645822
35SGK4941.23645822
36PLK21.22681696
37KSR11.22543393
38MAPK151.22183181
39SGK21.21814268
40PNCK1.21611307
41PHKG21.19907748
42PHKG11.19907748
43PRKCG1.16330497
44NEK21.13886747
45SGK31.10954571
46CAMK1D1.09143782
47ICK1.07953022
48PRKCH1.03386408
49CAMK1G1.02762377
50PRPF4B1.02423716
51TYRO30.99869028
52DDR20.98941806
53TAOK10.97149189
54PDK30.94721791
55PDK40.94721791
56TIE10.94377582
57LIMK10.93976919
58MAP3K20.93635007
59ARAF0.93214202
60FES0.92542011
61RET0.91617190
62CAMK10.91264664
63DAPK10.90386460
64TNK20.88765476
65TESK10.88197255
66WNK10.86623859
67MUSK0.84615463
68STK110.80316729
69CSNK1G30.79868653
70CAMK2A0.79147212
71PKN10.78390442
72CDK180.77614847
73PAK30.77215214
74PIK3CA0.77149238
75CDK150.76671391
76CSNK1A1L0.75195235
77CDK140.74891163
78MARK20.73046251
79WNK30.71654665
80ADRBK20.70811806
81PTK2B0.70396970
82UHMK10.70338085
83MAP4K20.69270933
84AKT30.68857035
85NEK10.68803516
86SGK10.67720876
87FER0.67651258
88CDK11A0.66164901
89CSNK1G20.66053049
90SIK30.65795220
91WNK40.65749050
92IRAK20.65652701
93ALK0.65601993
94NEK60.65282868
95CSNK1G10.64835795
96PRKCZ0.63707125
97ADRBK10.61801328
98DYRK1A0.61357701
99RPS6KA20.60490268
100SCYL20.60392961
101RIPK40.60086599
102MAP3K110.57411505
103PDK10.57088084
104PDGFRA0.56115694
105CDC42BPA0.55923963
106MKNK20.54895953
107SIK10.54665149
108RPS6KA30.54586411
109CSNK1E0.54000119
110RIPK10.51949178
111MAP3K10.51688962
112CDK190.50999806
113DMPK0.50861586
114ABL20.49814504
115RPS6KA60.49491484
116CAMK40.48924397
117MAP3K60.48672184
118RPS6KL10.47971666
119RPS6KC10.47971666
120STK38L0.47361384
121FGFR20.47155348
122MAPK100.46976643
123STK390.46972302
124MAP3K130.45890724
125PDPK10.44453030
126PRKCE0.44374642
127MAP3K100.44329566
128PRKACA0.43780508
129ERBB20.43316470
130INSRR0.43118201
131TLK10.42654659
132ROCK10.42347937
133PRKCB0.42137769
134OXSR10.38736726
135PDK20.38293360
136PAK20.38195395
137MTOR0.37238938
138CAMKK20.37168545
139DAPK30.36857832
140FYN0.36543756
141PRKAA10.36464388
142ROCK20.36219063

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.44575939
2Synaptic vesicle cycle_Homo sapiens_hsa047213.51933761
3Nicotine addiction_Homo sapiens_hsa050332.94781298
4Olfactory transduction_Homo sapiens_hsa047402.84548099
5Basal cell carcinoma_Homo sapiens_hsa052172.62611808
6GABAergic synapse_Homo sapiens_hsa047272.41365032
7Circadian entrainment_Homo sapiens_hsa047132.29521199
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20001010
9Glutamatergic synapse_Homo sapiens_hsa047242.18163182
10Hedgehog signaling pathway_Homo sapiens_hsa043402.17193244
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15261261
12Morphine addiction_Homo sapiens_hsa050322.05946957
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99213525
14Amphetamine addiction_Homo sapiens_hsa050311.98618059
15Ribosome_Homo sapiens_hsa030101.98449856
16Long-term potentiation_Homo sapiens_hsa047201.98403416
17Dopaminergic synapse_Homo sapiens_hsa047281.91902945
18Insulin secretion_Homo sapiens_hsa049111.90937813
19Notch signaling pathway_Homo sapiens_hsa043301.88746608
20Cholinergic synapse_Homo sapiens_hsa047251.82610955
21Gastric acid secretion_Homo sapiens_hsa049711.80643643
22Salivary secretion_Homo sapiens_hsa049701.78983288
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64815508
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62752787
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52508524
26Cocaine addiction_Homo sapiens_hsa050301.51056488
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49407721
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48994002
29Serotonergic synapse_Homo sapiens_hsa047261.46605593
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45014087
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41729655
32Taste transduction_Homo sapiens_hsa047421.41042000
33Parkinsons disease_Homo sapiens_hsa050121.40047116
34Oxytocin signaling pathway_Homo sapiens_hsa049211.38866201
35Renin secretion_Homo sapiens_hsa049241.38013857
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36047823
37Oxidative phosphorylation_Homo sapiens_hsa001901.35722792
38Butanoate metabolism_Homo sapiens_hsa006501.34925984
39Collecting duct acid secretion_Homo sapiens_hsa049661.34751698
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33677801
41Calcium signaling pathway_Homo sapiens_hsa040201.30692937
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14967954
43cAMP signaling pathway_Homo sapiens_hsa040241.12205247
44Huntingtons disease_Homo sapiens_hsa050161.09946695
45GnRH signaling pathway_Homo sapiens_hsa049121.09204109
46Long-term depression_Homo sapiens_hsa047301.08260201
47Sulfur relay system_Homo sapiens_hsa041221.06107094
48Steroid biosynthesis_Homo sapiens_hsa001001.05100696
49Linoleic acid metabolism_Homo sapiens_hsa005911.04622420
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04530785
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04072871
52Glioma_Homo sapiens_hsa052141.03776364
53Axon guidance_Homo sapiens_hsa043601.00849133
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00345434
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00285750
56Type II diabetes mellitus_Homo sapiens_hsa049301.00120901
57Gap junction_Homo sapiens_hsa045400.97979829
58ECM-receptor interaction_Homo sapiens_hsa045120.97877228
59Thyroid hormone synthesis_Homo sapiens_hsa049180.95786401
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95317268
61Cardiac muscle contraction_Homo sapiens_hsa042600.91938139
62Estrogen signaling pathway_Homo sapiens_hsa049150.91129936
63ErbB signaling pathway_Homo sapiens_hsa040120.91055634
64Alzheimers disease_Homo sapiens_hsa050100.90486257
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89239779
66Melanogenesis_Homo sapiens_hsa049160.86408302
67Vibrio cholerae infection_Homo sapiens_hsa051100.85410847
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84215773
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83916269
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.81064959
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.80545921
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78131963
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75288451
74Oocyte meiosis_Homo sapiens_hsa041140.74910562
75Dilated cardiomyopathy_Homo sapiens_hsa054140.72863308
76Dorso-ventral axis formation_Homo sapiens_hsa043200.72807059
77Retinol metabolism_Homo sapiens_hsa008300.71124597
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70438468
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69973495
80Caffeine metabolism_Homo sapiens_hsa002320.69112587
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.67272540
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66729739
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65670339
84MAPK signaling pathway_Homo sapiens_hsa040100.64905953
85Pancreatic secretion_Homo sapiens_hsa049720.63735153
86Basal transcription factors_Homo sapiens_hsa030220.63451576
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63369851
88Glucagon signaling pathway_Homo sapiens_hsa049220.63213466
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62890366
90Protein digestion and absorption_Homo sapiens_hsa049740.61630650
91Endometrial cancer_Homo sapiens_hsa052130.60447118
92mTOR signaling pathway_Homo sapiens_hsa041500.59001893
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57553784
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56825399
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56637578
96Ras signaling pathway_Homo sapiens_hsa040140.56423244
97Circadian rhythm_Homo sapiens_hsa047100.56171352
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55461657
99Mineral absorption_Homo sapiens_hsa049780.54235449
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.54037485
101Choline metabolism in cancer_Homo sapiens_hsa052310.53592608
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53089861
103Wnt signaling pathway_Homo sapiens_hsa043100.52771404
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52578633
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52542020
106Endocytosis_Homo sapiens_hsa041440.52115163
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52102125
108Prion diseases_Homo sapiens_hsa050200.51856512
109TGF-beta signaling pathway_Homo sapiens_hsa043500.51482275
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.51115391
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49503385
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49249464
113Fat digestion and absorption_Homo sapiens_hsa049750.47980458
114VEGF signaling pathway_Homo sapiens_hsa043700.47097519
115Inositol phosphate metabolism_Homo sapiens_hsa005620.46974756
116Rap1 signaling pathway_Homo sapiens_hsa040150.46943043
117Fatty acid degradation_Homo sapiens_hsa000710.46617328
118beta-Alanine metabolism_Homo sapiens_hsa004100.46003607
119Pathways in cancer_Homo sapiens_hsa052000.45612094
120Bile secretion_Homo sapiens_hsa049760.45099392
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44682513
122Alcoholism_Homo sapiens_hsa050340.44420439
123Tyrosine metabolism_Homo sapiens_hsa003500.43224446
124Lysine degradation_Homo sapiens_hsa003100.42707836
125Nitrogen metabolism_Homo sapiens_hsa009100.41969304
126Type I diabetes mellitus_Homo sapiens_hsa049400.41886853
127Tryptophan metabolism_Homo sapiens_hsa003800.41740898
128Focal adhesion_Homo sapiens_hsa045100.41330502
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41078451
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41020111
131Fatty acid biosynthesis_Homo sapiens_hsa000610.40556295
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39757769
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.38653061
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38582644
135Insulin signaling pathway_Homo sapiens_hsa049100.37169773
136Tight junction_Homo sapiens_hsa045300.37152460
137Non-small cell lung cancer_Homo sapiens_hsa052230.36080849
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.34737175
139Renal cell carcinoma_Homo sapiens_hsa052110.33704624
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.33287171
141Melanoma_Homo sapiens_hsa052180.33022358
142Ovarian steroidogenesis_Homo sapiens_hsa049130.30091679
143Hippo signaling pathway_Homo sapiens_hsa043900.29527831
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27863899
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27482029

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