ELFN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.71241480
2synaptic vesicle maturation (GO:0016188)6.51181925
3locomotory exploration behavior (GO:0035641)6.46519846
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.15465093
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.74879417
6vocalization behavior (GO:0071625)5.68672039
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.45809907
8synaptic vesicle exocytosis (GO:0016079)5.36306767
9glutamate secretion (GO:0014047)5.26518841
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.25077984
11regulation of glutamate receptor signaling pathway (GO:1900449)5.15898541
12regulation of synaptic vesicle exocytosis (GO:2000300)5.07419812
13exploration behavior (GO:0035640)4.93887864
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.89131086
15protein localization to synapse (GO:0035418)4.89073427
16regulation of neuronal synaptic plasticity (GO:0048168)4.86574127
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.71481743
18regulation of synapse structural plasticity (GO:0051823)4.59781091
19regulation of synaptic vesicle transport (GO:1902803)4.54468527
20neuron cell-cell adhesion (GO:0007158)4.51156066
21dendritic spine morphogenesis (GO:0060997)4.50692410
22neurotransmitter secretion (GO:0007269)4.49521224
23layer formation in cerebral cortex (GO:0021819)4.40902266
24amino acid import (GO:0043090)4.38312036
25synaptic transmission, glutamatergic (GO:0035249)4.33877457
26glutamate receptor signaling pathway (GO:0007215)4.18746668
27neurotransmitter-gated ion channel clustering (GO:0072578)4.17149778
28long-term memory (GO:0007616)4.11278906
29neuronal action potential propagation (GO:0019227)4.09797988
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08080251
31positive regulation of membrane potential (GO:0045838)4.06111098
32proline transport (GO:0015824)4.05402024
33cellular potassium ion homeostasis (GO:0030007)4.02190240
34cytoskeletal anchoring at plasma membrane (GO:0007016)4.00423745
35cerebellar granule cell differentiation (GO:0021707)3.96395279
36neuron-neuron synaptic transmission (GO:0007270)3.95865355
37sodium ion export (GO:0071436)3.95856439
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93044603
39gamma-aminobutyric acid transport (GO:0015812)3.91019605
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84196742
41regulation of dendritic spine morphogenesis (GO:0061001)3.80487037
42regulation of synaptic plasticity (GO:0048167)3.75918161
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.73532332
44regulation of postsynaptic membrane potential (GO:0060078)3.72864286
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.68596650
46positive regulation of synapse maturation (GO:0090129)3.64474162
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64346113
48neurotransmitter transport (GO:0006836)3.63759821
49neuromuscular process controlling balance (GO:0050885)3.63591063
50synaptic vesicle endocytosis (GO:0048488)3.55636486
51potassium ion homeostasis (GO:0055075)3.52805545
52activation of protein kinase A activity (GO:0034199)3.51227040
53auditory behavior (GO:0031223)3.49808335
54transmission of nerve impulse (GO:0019226)3.48217250
55hemidesmosome assembly (GO:0031581)3.47797959
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47118368
57negative regulation of dendrite morphogenesis (GO:0050774)3.43916072
58regulation of neurotransmitter secretion (GO:0046928)3.43679403
59L-amino acid import (GO:0043092)3.41460872
60neuron recognition (GO:0008038)3.41166029
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.40419572
62regulation of neurotransmitter levels (GO:0001505)3.36420579
63prepulse inhibition (GO:0060134)3.35954113
64long-term synaptic potentiation (GO:0060291)3.35351957
65dendrite morphogenesis (GO:0048813)3.35342766
66neuromuscular process controlling posture (GO:0050884)3.33609800
67response to auditory stimulus (GO:0010996)3.33096411
68cell communication by electrical coupling (GO:0010644)3.32955886
69mating behavior (GO:0007617)3.30127114
70glycine transport (GO:0015816)3.29614194
71regulation of ARF protein signal transduction (GO:0032012)3.28632677
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27621701
73regulation of vesicle fusion (GO:0031338)3.27260047
74dendritic spine organization (GO:0097061)3.26870344
75positive regulation of neurotransmitter transport (GO:0051590)3.25804193
76positive regulation of neurotransmitter secretion (GO:0001956)3.25053639
77positive regulation of dendritic spine development (GO:0060999)3.24081420
78neuronal ion channel clustering (GO:0045161)3.23994884
79postsynaptic membrane organization (GO:0001941)3.22217641
80regulation of neurotransmitter transport (GO:0051588)3.19776324
81membrane depolarization during action potential (GO:0086010)3.19520320
82membrane depolarization (GO:0051899)3.18535864
83membrane hyperpolarization (GO:0060081)3.17996098
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17858870
85innervation (GO:0060384)3.17259011
86regulation of synapse maturation (GO:0090128)3.17198679
87learning (GO:0007612)3.16584306
88regulation of dendritic spine development (GO:0060998)3.16540800
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16313976
90axonal fasciculation (GO:0007413)3.15860409
91cerebellar Purkinje cell layer development (GO:0021680)3.10710597
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10428221
93cerebellar Purkinje cell differentiation (GO:0021702)3.10009743
94behavioral defense response (GO:0002209)3.08138374
95behavioral fear response (GO:0001662)3.08138374
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05805769
97intraspecies interaction between organisms (GO:0051703)3.04795880
98social behavior (GO:0035176)3.04795880
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.04234130
100chemosensory behavior (GO:0007635)3.03671918
101regulation of synaptic transmission (GO:0050804)3.03007112
102response to histamine (GO:0034776)3.02959999
103gamma-aminobutyric acid signaling pathway (GO:0007214)3.01994304
104positive regulation of synaptic transmission (GO:0050806)3.01690680
105vesicle transport along microtubule (GO:0047496)3.00911766
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00586679
107neuromuscular process (GO:0050905)2.99657577
108potassium ion import (GO:0010107)2.99488988
109calcium ion-dependent exocytosis (GO:0017156)2.98626868
110axon ensheathment in central nervous system (GO:0032291)2.97032407
111central nervous system myelination (GO:0022010)2.97032407
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96010390
113presynaptic membrane assembly (GO:0097105)2.95000100
114positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93800288
115presynaptic membrane organization (GO:0097090)2.80382030
116regulation of voltage-gated calcium channel activity (GO:1901385)2.79900154
117cell migration in hindbrain (GO:0021535)2.76044438
118acidic amino acid transport (GO:0015800)2.75683525
119response to gravity (GO:0009629)2.75369214
120activation of Rac GTPase activity (GO:0032863)2.73482662
121membrane assembly (GO:0071709)2.72040997
122positive regulation of dendrite development (GO:1900006)2.67540275
123cellular sodium ion homeostasis (GO:0006883)2.65427826
124establishment of mitochondrion localization (GO:0051654)2.61357605
125visual learning (GO:0008542)2.55162656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.23389707
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.07964129
3GBX2_23144817_ChIP-Seq_PC3_Human3.22566324
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94322225
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88766920
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.85923663
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83499017
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.83053955
9DROSHA_22980978_ChIP-Seq_HELA_Human2.79094911
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55468730
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55468730
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53067602
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50574339
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47340000
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46690831
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39915654
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.33881678
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30610123
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.28381616
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28160163
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25445115
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.23687406
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22884605
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17718134
25* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13331594
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09812733
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09373868
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02469992
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.97788417
30AR_21572438_ChIP-Seq_LNCaP_Human1.95755927
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86080033
32LXR_22292898_ChIP-Seq_THP-1_Human1.83142265
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74409550
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66436076
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.64593781
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62232445
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61505890
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.57956374
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53116409
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51800045
41SMAD4_21799915_ChIP-Seq_A2780_Human1.51179433
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47010097
43* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46223627
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45911858
45* ERG_21242973_ChIP-ChIP_JURKAT_Human1.45898720
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44603761
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38844847
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.38097276
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35850246
50ZNF263_19887448_ChIP-Seq_K562_Human1.33323207
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30980177
52ZNF274_21170338_ChIP-Seq_K562_Hela1.30383914
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.29428761
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28901899
55SMC4_20622854_ChIP-Seq_HELA_Human1.28312659
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27024759
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.27024468
58KDM2B_26808549_Chip-Seq_K562_Human1.26942433
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26884528
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24046366
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22617857
62AR_19668381_ChIP-Seq_PC3_Human1.21517704
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20813027
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19661322
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19598679
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19309929
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.18579937
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17080837
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16744853
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16644675
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16205992
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.16084914
73STAT3_23295773_ChIP-Seq_U87_Human1.15284127
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14721954
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12966526
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12917951
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12417544
78TP53_23651856_ChIP-Seq_MEFs_Mouse1.12373168
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.12013243
80AR_25329375_ChIP-Seq_VCAP_Human1.11093659
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10544342
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07416057
83RACK7_27058665_Chip-Seq_MCF-7_Human1.07002522
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06806933
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06205918
86TAF15_26573619_Chip-Seq_HEK293_Human1.05883054
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05486849
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05113940
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.05102037
90CREB1_26743006_Chip-Seq_LNCaP_Human1.05090835
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04783119
92P300_19829295_ChIP-Seq_ESCs_Human1.04150260
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03801802
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.03627785
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.03621730
96* TCF4_23295773_ChIP-Seq_U87_Human1.03597496
97KDM2B_26808549_Chip-Seq_DND41_Human1.03438893
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01924575
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00542210
100P68_20966046_ChIP-Seq_HELA_Human0.99031832
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98711795
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98169866
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96603674
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96467623
105* CTCF_27219007_Chip-Seq_Bcells_Human0.96356119
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.95868752
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95817918
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95778789
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94857775
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94857775
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94800911
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.94737754
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94336667
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.93687110
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.92864020
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92594188
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92465524
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91838595
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91543613
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.91396156
121TP53_16413492_ChIP-PET_HCT116_Human0.91132918
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90876484
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.90324463
124* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90177776
125AHR_22903824_ChIP-Seq_MCF-7_Human0.89986178
126* TP53_22127205_ChIP-Seq_IMR90_Human0.89491733
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88594700
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88527477
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87673102
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86145291
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85583470
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85364323
133RNF2_27304074_Chip-Seq_NSC_Mouse0.85355219
134* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84676208
135MYC_19915707_ChIP-ChIP_AK7_Human0.84053272
136RUNX2_22187159_ChIP-Seq_PCA_Human0.83354989
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83258137
138* OCT4_19829295_ChIP-Seq_ESCs_Human0.83180317
139* KLF4_19829295_ChIP-Seq_ESCs_Human0.81946653
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.81617771
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81577398
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81321453
143CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78161686
144TP63_22573176_ChIP-Seq_HFKS_Human0.77727908
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.75995672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.35188636
2MP0003880_abnormal_central_pattern4.70324600
3MP0003635_abnormal_synaptic_transmissio4.33994791
4MP0004270_analgesia3.86992281
5MP0009745_abnormal_behavioral_response3.48191834
6MP0002063_abnormal_learning/memory/cond3.45380555
7MP0002822_catalepsy3.33350576
8MP0002064_seizures3.26630280
9MP0005423_abnormal_somatic_nervous3.20734224
10MP0009046_muscle_twitch3.16114596
11MP0002572_abnormal_emotion/affect_behav2.80133714
12MP0001968_abnormal_touch/_nociception2.72737662
13MP0001486_abnormal_startle_reflex2.69912076
14MP0002734_abnormal_mechanical_nocicepti2.54840688
15MP0002272_abnormal_nervous_system2.53449166
16MP0001501_abnormal_sleep_pattern2.18958052
17MP0009780_abnormal_chondrocyte_physiolo2.18388358
18MP0000579_abnormal_nail_morphology2.03604442
19MP0001348_abnormal_lacrimal_gland1.97548812
20MP0008569_lethality_at_weaning1.93299181
21MP0004811_abnormal_neuron_physiology1.91184813
22MP0001440_abnormal_grooming_behavior1.90485490
23MP0002735_abnormal_chemical_nociception1.89814299
24MP0002736_abnormal_nociception_after1.87449119
25MP0002733_abnormal_thermal_nociception1.86182692
26MP0001970_abnormal_pain_threshold1.81286938
27MP0003329_amyloid_beta_deposits1.80874589
28MP0004858_abnormal_nervous_system1.80000836
29MP0002067_abnormal_sensory_capabilities1.77109556
30MP0002909_abnormal_adrenal_gland1.75799127
31MP0000778_abnormal_nervous_system1.72212158
32MP0005646_abnormal_pituitary_gland1.71539912
33MP0002557_abnormal_social/conspecific_i1.70365326
34MP0003705_abnormal_hypodermis_morpholog1.68431242
35MP0002184_abnormal_innervation1.67507286
36MP0003879_abnormal_hair_cell1.63240875
37MP0004924_abnormal_behavior1.62838080
38MP0005386_behavior/neurological_phenoty1.62838080
39MP0004885_abnormal_endolymph1.62735207
40MP0000955_abnormal_spinal_cord1.58937409
41MP0001984_abnormal_olfaction1.51156386
42MP0002882_abnormal_neuron_morphology1.45874553
43MP0002066_abnormal_motor_capabilities/c1.41047007
44MP0003633_abnormal_nervous_system1.39165495
45MP0003787_abnormal_imprinting1.36270743
46MP0005409_darkened_coat_color1.36190849
47MP0001529_abnormal_vocalization1.23980265
48MP0005551_abnormal_eye_electrophysiolog1.22685069
49MP0001849_ear_inflammation1.21774674
50MP0003631_nervous_system_phenotype1.19984425
51MP0001502_abnormal_circadian_rhythm1.19915128
52MP0005645_abnormal_hypothalamus_physiol1.18859878
53MP0000569_abnormal_digit_pigmentation1.17331454
54MP0006276_abnormal_autonomic_nervous1.14928326
55MP0010234_abnormal_vibrissa_follicle1.14356387
56MP0002152_abnormal_brain_morphology1.14343552
57MP0004142_abnormal_muscle_tone1.11965136
58MP0000566_synostosis1.11767898
59MP0001905_abnormal_dopamine_level1.11157665
60MP0003075_altered_response_to1.09723042
61MP0008961_abnormal_basal_metabolism1.09135948
62MP0005410_abnormal_fertilization1.08629801
63MP0001177_atelectasis1.07001527
64MP0003690_abnormal_glial_cell1.03606208
65MP0002229_neurodegeneration1.03478467
66MP0000534_abnormal_ureter_morphology1.03085164
67MP0008872_abnormal_physiological_respon0.98835245
68MP0003123_paternal_imprinting0.97699188
69MP0000920_abnormal_myelination0.96429666
70MP0002069_abnormal_eating/drinking_beha0.95511908
71MP0002090_abnormal_vision0.93808935
72MP0008874_decreased_physiological_sensi0.93751084
73MP0001188_hyperpigmentation0.93591552
74MP0000762_abnormal_tongue_morphology0.92833270
75MP0003283_abnormal_digestive_organ0.91107016
76MP0002089_abnormal_postnatal_growth/wei0.90828055
77MP0003632_abnormal_nervous_system0.88875712
78MP0000537_abnormal_urethra_morphology0.88667270
79MP0003634_abnormal_glial_cell0.88455480
80MP0000751_myopathy0.86534828
81MP0005394_taste/olfaction_phenotype0.85037141
82MP0005499_abnormal_olfactory_system0.85037141
83MP0002249_abnormal_larynx_morphology0.85007439
84MP0005535_abnormal_body_temperature0.84018102
85MP0003122_maternal_imprinting0.80810965
86MP0004085_abnormal_heartbeat0.80393189
87MP0004233_abnormal_muscle_weight0.79261879
88MP0003172_abnormal_lysosome_physiology0.79001102
89MP0005167_abnormal_blood-brain_barrier0.78656705
90MP0000604_amyloidosis0.76333763
91MP0003091_abnormal_cell_migration0.75471030
92MP0002752_abnormal_somatic_nervous0.74561640
93MP0001958_emphysema0.74114203
94MP0000631_abnormal_neuroendocrine_gland0.73876130
95MP0001963_abnormal_hearing_physiology0.73387153
96MP0004742_abnormal_vestibular_system0.72710132
97MP0000467_abnormal_esophagus_morphology0.72437755
98MP0003183_abnormal_peptide_metabolism0.72171016
99MP0004130_abnormal_muscle_cell0.71820648
100MP0000462_abnormal_digestive_system0.69140802
101MP0004145_abnormal_muscle_electrophysio0.68040596
102MP0005623_abnormal_meninges_morphology0.67991508
103MP0002877_abnormal_melanocyte_morpholog0.67680214
104MP0003566_abnormal_cell_adhesion0.63939337
105MP0004510_myositis0.63426054
106MP0001299_abnormal_eye_distance/0.61689324
107MP0010386_abnormal_urinary_bladder0.61520427
108MP0003698_abnormal_male_reproductive0.61234062
109MP0000013_abnormal_adipose_tissue0.60289668
110MP0002082_postnatal_lethality0.59720548
111MP0010770_preweaning_lethality0.59720548
112MP0003861_abnormal_nervous_system0.59127630
113MP0001731_abnormal_postnatal_growth0.58415204
114MP0002653_abnormal_ependyma_morphology0.57950521
115MP0003137_abnormal_impulse_conducting0.57779385
116MP0010768_mortality/aging0.56618650
117MP0000733_abnormal_muscle_development0.56535861
118MP0002295_abnormal_pulmonary_circulatio0.56222365
119MP0002081_perinatal_lethality0.56109764
120MP0000026_abnormal_inner_ear0.55442452
121MP0004043_abnormal_pH_regulation0.55090056
122MP0001485_abnormal_pinna_reflex0.54636572
123MP0000747_muscle_weakness0.54554399
124MP0010769_abnormal_survival0.53804054
125MP0001943_abnormal_respiration0.53342141
126MP0001664_abnormal_digestion0.52953997
127MP0003956_abnormal_body_size0.51390869

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.31965056
2Focal motor seizures (HP:0011153)6.91650127
3Focal seizures (HP:0007359)5.44330073
4Visual hallucinations (HP:0002367)4.93659607
5Epileptic encephalopathy (HP:0200134)4.43799575
6Progressive cerebellar ataxia (HP:0002073)4.19313350
7Febrile seizures (HP:0002373)3.85512799
8Ankle clonus (HP:0011448)3.85010893
9Action tremor (HP:0002345)3.82324577
10Supranuclear gaze palsy (HP:0000605)3.72064313
11Atonic seizures (HP:0010819)3.70334282
12Absence seizures (HP:0002121)3.69841378
13Generalized tonic-clonic seizures (HP:0002069)3.57442858
14Insomnia (HP:0100785)3.54478803
15Impaired vibration sensation in the lower limbs (HP:0002166)3.51924511
16Dialeptic seizures (HP:0011146)3.41562150
17Urinary bladder sphincter dysfunction (HP:0002839)3.30420105
18Mutism (HP:0002300)3.28521301
19Gaze-evoked nystagmus (HP:0000640)3.27197626
20Depression (HP:0000716)3.25200103
21Broad-based gait (HP:0002136)3.24544978
22Postural instability (HP:0002172)3.23287060
23Truncal ataxia (HP:0002078)3.21252113
24Poor eye contact (HP:0000817)3.21144638
25Fragile skin (HP:0001030)3.21104588
26Abnormality of the lower motor neuron (HP:0002366)3.16384958
27Dysmetria (HP:0001310)3.12761432
28Papilledema (HP:0001085)3.12173530
29Atrophic scars (HP:0001075)3.03549400
30Dysdiadochokinesis (HP:0002075)3.02997132
31Hyperacusis (HP:0010780)2.97942482
32Abnormal social behavior (HP:0012433)2.92561843
33Impaired social interactions (HP:0000735)2.92561843
34Limb dystonia (HP:0002451)2.90336051
35Torticollis (HP:0000473)2.88591779
36Urinary urgency (HP:0000012)2.87030851
37Elfin facies (HP:0004428)2.84983878
38Anxiety (HP:0000739)2.83166085
39Genetic anticipation (HP:0003743)2.81142836
40Spastic gait (HP:0002064)2.80031488
41Akinesia (HP:0002304)2.78417895
42Overriding aorta (HP:0002623)2.73752551
43Absent/shortened dynein arms (HP:0200106)2.73751941
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.73751941
45Abnormal eating behavior (HP:0100738)2.72530879
46Megalencephaly (HP:0001355)2.68862179
47Intention tremor (HP:0002080)2.68833459
48Pointed chin (HP:0000307)2.67983242
49Impaired smooth pursuit (HP:0007772)2.64481144
50Focal dystonia (HP:0004373)2.63199100
51Neurofibrillary tangles (HP:0002185)2.62772609
52Upper limb amyotrophy (HP:0009129)2.62392146
53Distal upper limb amyotrophy (HP:0007149)2.62392146
54Milia (HP:0001056)2.54771108
55Hyperventilation (HP:0002883)2.53490222
56Hemiparesis (HP:0001269)2.53164593
57Ventricular fibrillation (HP:0001663)2.51252972
58Stereotypic behavior (HP:0000733)2.51036265
59Amblyopia (HP:0000646)2.47868379
60Drooling (HP:0002307)2.46520708
61Excessive salivation (HP:0003781)2.46520708
62Apathy (HP:0000741)2.44321484
63Cerebral inclusion bodies (HP:0100314)2.42966207
64Abnormality of ocular smooth pursuit (HP:0000617)2.42576049
65Bradykinesia (HP:0002067)2.41795376
66Renovascular hypertension (HP:0100817)2.40875380
67Hemiplegia (HP:0002301)2.39509442
68Impaired vibratory sensation (HP:0002495)2.37962635
69Lower limb muscle weakness (HP:0007340)2.35006151
70Generalized myoclonic seizures (HP:0002123)2.33727920
71Craniofacial dystonia (HP:0012179)2.32152093
72Flat cornea (HP:0007720)2.30249145
73Progressive inability to walk (HP:0002505)2.28020744
74Bronchomalacia (HP:0002780)2.26408441
75Ankyloglossia (HP:0010296)2.25611636
76Scanning speech (HP:0002168)2.21633875
77Epileptiform EEG discharges (HP:0011182)2.20039116
78Abnormality of the corticospinal tract (HP:0002492)2.18644434
79Aplasia involving bones of the upper limbs (HP:0009823)2.18271628
80Aplasia of the phalanges of the hand (HP:0009802)2.18271628
81Aplasia involving bones of the extremities (HP:0009825)2.18271628
82Broad face (HP:0000283)2.17681243
83Arterial tortuosity (HP:0005116)2.14453842
84Absent speech (HP:0001344)2.13632835
85Diminished motivation (HP:0000745)2.13494690
86Hand muscle atrophy (HP:0009130)2.13059480
87Polygenic inheritance (HP:0010982)2.12622504
88EEG with generalized epileptiform discharges (HP:0011198)2.11798143
89Clonus (HP:0002169)2.11758859
90Abnormality of binocular vision (HP:0011514)2.10435592
91Diplopia (HP:0000651)2.10435592
92Protrusio acetabuli (HP:0003179)2.09818809
93Annular pancreas (HP:0001734)2.09317103
94Dysmetric saccades (HP:0000641)2.05848807
95Termporal pattern (HP:0011008)2.04139387
96Insidious onset (HP:0003587)2.04139387
97Amyotrophic lateral sclerosis (HP:0007354)2.04051471
98Status epilepticus (HP:0002133)2.03943797
99Renal duplication (HP:0000075)2.03716699
100Rigidity (HP:0002063)2.02758189
101Urethral obstruction (HP:0000796)2.02127843
102Shallow orbits (HP:0000586)2.01819055
103Tetraplegia (HP:0002445)2.01593208
104Hypsarrhythmia (HP:0002521)2.01022599
105Fetal akinesia sequence (HP:0001989)1.98536010
106Rapidly progressive (HP:0003678)1.98415673
107Obstructive sleep apnea (HP:0002870)1.96261617
108Abnormality of oral frenula (HP:0000190)1.96239592
109Turricephaly (HP:0000262)1.94664463
110Bundle branch block (HP:0011710)1.94609282
111Vascular tortuosity (HP:0004948)1.93215476
112Lower limb amyotrophy (HP:0007210)1.92800651
113Fragile nails (HP:0001808)1.92733256
114Anosmia (HP:0000458)1.91890753
115Sleep apnea (HP:0010535)1.90217377
116Abnormality of saccadic eye movements (HP:0000570)1.86959773
117Gait ataxia (HP:0002066)1.86365929
118Sensory axonal neuropathy (HP:0003390)1.85633739
119Pheochromocytoma (HP:0002666)1.85251437
120Peripheral hypomyelination (HP:0007182)1.84348008
121Neuronal loss in central nervous system (HP:0002529)1.82743380
122Abnormal EKG (HP:0003115)1.82220091
123Morphological abnormality of the pyramidal tract (HP:0002062)1.80956736
124Delusions (HP:0000746)1.80894873
125Difficulty climbing stairs (HP:0003551)1.79878157
126Premature rupture of membranes (HP:0001788)1.79428597
127Abnormal respiratory motile cilium physiology (HP:0012261)1.79299637
128Ulnar bowing (HP:0003031)1.76204108
129Incomplete penetrance (HP:0003829)1.75958119
130Distal lower limb amyotrophy (HP:0008944)1.75860002
131Hypoventilation (HP:0002791)1.74940433
132Obsessive-compulsive behavior (HP:0000722)1.74629533
133Polyphagia (HP:0002591)1.74598536
134Spastic tetraparesis (HP:0001285)1.73907569
135Diminished movement (HP:0002374)1.69667957
136Bladder diverticulum (HP:0000015)1.69049807
137Nuclear cataract (HP:0100018)1.67310367
138Distal sensory impairment (HP:0002936)1.67105598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.57362026
2MAP3K94.53593379
3NTRK34.50532418
4MARK13.25915694
5MST1R3.25764943
6PRKD32.90805046
7EPHA22.77426870
8MAP3K42.67987819
9MINK12.65039388
10PAK62.55062558
11DAPK22.52914826
12NTRK22.29275031
13KSR22.06569955
14MAP2K72.05355417
15CAMKK12.05107059
16NTRK11.98119656
17MET1.83215039
18STK381.71375974
19TNIK1.65120383
20CDK51.60400502
21RIPK41.54915963
22MAP2K41.53553517
23SIK11.45403816
24PTK21.45266767
25DAPK11.43898528
26KSR11.43221372
27PRPF4B1.42958771
28TYRO31.42477668
29FES1.38864429
30TAOK11.36346282
31SIK21.30653089
32PDGFRA1.22085130
33MAP3K21.19543847
34PRKCG1.17652644
35MAPK131.16064935
36GRK51.09895602
37MAP3K121.08826355
38UHMK11.08024276
39TRIB31.07100432
40CAMK11.05404990
41PNCK1.03865946
42PLK21.03455679
43PHKG21.02764046
44PHKG11.02764046
45CDK190.99992582
46TESK10.99654293
47MAP3K130.98631235
48ARAF0.98009990
49LATS20.95912700
50STK110.95464544
51PRKCH0.94778719
52ALK0.94387331
53PDK40.93531865
54PDK30.93531865
55CAMK2A0.91006182
56SGK2230.89763029
57SGK4940.89763029
58LIMK10.89619007
59CDK150.88745019
60MARK20.88582520
61CDK180.87789570
62PDK10.83429706
63CDK140.82629665
64LMTK20.79877211
65ICK0.78969201
66ROCK20.78221716
67PAK30.77696687
68CDK11A0.76612905
69PTK2B0.76371981
70RET0.75291084
71NEK60.74623262
72SGK30.73655368
73CASK0.73108410
74PINK10.72231993
75RAF10.70621156
76SGK20.70510914
77BRAF0.70498246
78CAMK2B0.70068896
79SGK10.69436031
80RIPK10.69285463
81TNK20.68518058
82MAP3K70.68019211
83TTN0.67142971
84PDPK10.64197456
85DYRK1A0.63841929
86BMX0.61677472
87CSNK1G20.61396037
88CAMKK20.58792324
89PRKG20.57203436
90MAP3K10.56481531
91DMPK0.56345876
92PRKD20.56042843
93RPS6KA30.54778843
94OXSR10.54744846
95RPS6KA20.54380542
96CAMK1G0.54333761
97FYN0.54247966
98PRKCZ0.54099354
99MAPK120.53068286
100ROCK10.52837120
101PAK20.52344318
102MAPK100.52100652
103BRSK10.50489882
104EPHB20.49503274
105CDK120.46490891
106CDC42BPA0.45859665
107NEK10.45717861
108ERBB40.44393349
109CAMK40.44022369
110MOS0.44016640
111SMG10.43270668
112BMPR20.41187436
113IRAK30.40091979
114MTOR0.37678751
115CAMK2D0.37155135
116PDK20.36885985
117PDGFRB0.35851845
118PRKCI0.35680948
119SCYL20.35191648
120EEF2K0.34865531
121MAP3K110.34706594
122DAPK30.34034175
123PRKCB0.33620584
124EPHB10.33471979
125WNK10.33422874
126CAMK1D0.33117216
127ABL20.31860723
128DDR20.31561871
129PKN10.31359705
130CAMK2G0.31117549
131PRKCE0.29046298
132MAPK80.28493027

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48998839
2Synaptic vesicle cycle_Homo sapiens_hsa047213.13595561
3Olfactory transduction_Homo sapiens_hsa047402.91466864
4Circadian entrainment_Homo sapiens_hsa047132.76461633
5GABAergic synapse_Homo sapiens_hsa047272.68053200
6Glutamatergic synapse_Homo sapiens_hsa047242.62932239
7Long-term potentiation_Homo sapiens_hsa047202.60429016
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52586753
9Morphine addiction_Homo sapiens_hsa050322.49051981
10Amphetamine addiction_Homo sapiens_hsa050312.45524690
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31108314
12Salivary secretion_Homo sapiens_hsa049702.22954713
13Dopaminergic synapse_Homo sapiens_hsa047282.11350459
14Gastric acid secretion_Homo sapiens_hsa049712.08306462
15Insulin secretion_Homo sapiens_hsa049112.04127632
16Cholinergic synapse_Homo sapiens_hsa047251.96859885
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92779382
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73185772
19Vitamin B6 metabolism_Homo sapiens_hsa007501.71713119
20Oxytocin signaling pathway_Homo sapiens_hsa049211.69317965
21Renin secretion_Homo sapiens_hsa049241.64271958
22Cocaine addiction_Homo sapiens_hsa050301.64124259
23Calcium signaling pathway_Homo sapiens_hsa040201.59714638
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53254861
25Long-term depression_Homo sapiens_hsa047301.53237714
26Serotonergic synapse_Homo sapiens_hsa047261.51734206
27Nitrogen metabolism_Homo sapiens_hsa009101.49661035
28Taste transduction_Homo sapiens_hsa047421.48287736
29GnRH signaling pathway_Homo sapiens_hsa049121.44489143
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37391384
31Gap junction_Homo sapiens_hsa045401.32204603
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30681976
33cAMP signaling pathway_Homo sapiens_hsa040241.30173686
34Type II diabetes mellitus_Homo sapiens_hsa049301.26209526
35Glioma_Homo sapiens_hsa052141.24781960
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24687679
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23136110
38ErbB signaling pathway_Homo sapiens_hsa040121.18448900
39Estrogen signaling pathway_Homo sapiens_hsa049151.16311843
40Axon guidance_Homo sapiens_hsa043601.11869665
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11374069
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05503727
43Dorso-ventral axis formation_Homo sapiens_hsa043201.04782814
44Phototransduction_Homo sapiens_hsa047441.03962891
45Melanogenesis_Homo sapiens_hsa049161.01583590
46ECM-receptor interaction_Homo sapiens_hsa045120.99145856
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.98112499
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.94216652
49Oocyte meiosis_Homo sapiens_hsa041140.92359779
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91708001
51Collecting duct acid secretion_Homo sapiens_hsa049660.90473312
52Focal adhesion_Homo sapiens_hsa045100.90309591
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88390797
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86038634
55Pancreatic secretion_Homo sapiens_hsa049720.85034625
56Cardiac muscle contraction_Homo sapiens_hsa042600.84129908
57Hippo signaling pathway_Homo sapiens_hsa043900.82473973
58Thyroid hormone synthesis_Homo sapiens_hsa049180.79057552
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78091939
60Choline metabolism in cancer_Homo sapiens_hsa052310.77660616
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77405922
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75500310
63Dilated cardiomyopathy_Homo sapiens_hsa054140.74515510
64MAPK signaling pathway_Homo sapiens_hsa040100.73228180
65VEGF signaling pathway_Homo sapiens_hsa043700.70066908
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.68317846
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65925933
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64983088
69Glucagon signaling pathway_Homo sapiens_hsa049220.63031907
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62677982
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62331954
72Endocytosis_Homo sapiens_hsa041440.61613564
73mTOR signaling pathway_Homo sapiens_hsa041500.61356498
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60929124
75Proteoglycans in cancer_Homo sapiens_hsa052050.59910332
76Ras signaling pathway_Homo sapiens_hsa040140.59682817
77Rap1 signaling pathway_Homo sapiens_hsa040150.59621674
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59034278
79Alcoholism_Homo sapiens_hsa050340.58407747
80Tight junction_Homo sapiens_hsa045300.57571726
81Bile secretion_Homo sapiens_hsa049760.56915294
82Vibrio cholerae infection_Homo sapiens_hsa051100.56435995
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.55342436
84AMPK signaling pathway_Homo sapiens_hsa041520.53650119
85Chronic myeloid leukemia_Homo sapiens_hsa052200.52251778
86Inositol phosphate metabolism_Homo sapiens_hsa005620.52185457
87Adherens junction_Homo sapiens_hsa045200.51870044
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51316869
89Non-small cell lung cancer_Homo sapiens_hsa052230.51200501
90Notch signaling pathway_Homo sapiens_hsa043300.49320497
91Endometrial cancer_Homo sapiens_hsa052130.47244211
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45689622
93Renal cell carcinoma_Homo sapiens_hsa052110.45010472
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44122842
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43967603
96Type I diabetes mellitus_Homo sapiens_hsa049400.43335820
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42816338
98Wnt signaling pathway_Homo sapiens_hsa043100.42718173
99Insulin signaling pathway_Homo sapiens_hsa049100.42333666
100Circadian rhythm_Homo sapiens_hsa047100.41414081
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41216571
102Prion diseases_Homo sapiens_hsa050200.39745358
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39227719
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38369566
105Amoebiasis_Homo sapiens_hsa051460.37130588
106Ovarian steroidogenesis_Homo sapiens_hsa049130.36541005
107Chemokine signaling pathway_Homo sapiens_hsa040620.36447323
108Prolactin signaling pathway_Homo sapiens_hsa049170.35605510
109Melanoma_Homo sapiens_hsa052180.35230790
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34885065
111MicroRNAs in cancer_Homo sapiens_hsa052060.34499562
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34297722
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.33702780
114African trypanosomiasis_Homo sapiens_hsa051430.31030470
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30692000
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29591742
117Fatty acid biosynthesis_Homo sapiens_hsa000610.28052561
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27118336
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.26753349

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