ELK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.07263445
2regulation of gamma-delta T cell differentiation (GO:0045586)5.42656735
3regulation of gamma-delta T cell activation (GO:0046643)5.00360457
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.97963724
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97963724
6antigen processing and presentation of endogenous antigen (GO:0019883)4.60915901
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.57712850
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.52224933
9positive thymic T cell selection (GO:0045059)4.47523055
10negative T cell selection (GO:0043383)4.45456338
11regulation of histone H3-K27 methylation (GO:0061085)4.45242622
12negative thymic T cell selection (GO:0045060)4.18790030
13positive T cell selection (GO:0043368)4.17269388
14T cell selection (GO:0045058)3.97713950
15positive regulation of B cell differentiation (GO:0045579)3.95743942
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.93192445
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90673312
18thymic T cell selection (GO:0045061)3.86076967
19histone H3-K36 demethylation (GO:0070544)3.77168804
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68866760
21regulation of B cell differentiation (GO:0045577)3.64021757
22interferon-gamma production (GO:0032609)3.63785848
23interkinetic nuclear migration (GO:0022027)3.62363403
24monoubiquitinated protein deubiquitination (GO:0035520)3.61360541
25cellular response to ethanol (GO:0071361)3.53134347
26response to interleukin-15 (GO:0070672)3.47837829
27B cell receptor signaling pathway (GO:0050853)3.46406814
28definitive hemopoiesis (GO:0060216)3.45706351
29nuclear pore complex assembly (GO:0051292)3.43617544
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38869080
31negative regulation of cell killing (GO:0031342)3.38869080
32regulation of B cell receptor signaling pathway (GO:0050855)3.36981506
33histone H3-K4 trimethylation (GO:0080182)3.35679142
34cytoplasmic mRNA processing body assembly (GO:0033962)3.35120747
35embryonic process involved in female pregnancy (GO:0060136)3.34831841
36regulation of T cell tolerance induction (GO:0002664)3.34549642
37hepatocyte apoptotic process (GO:0097284)3.17481699
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.13824728
39positive regulation of histone deacetylation (GO:0031065)3.11616304
40T cell homeostasis (GO:0043029)3.06679641
41tolerance induction (GO:0002507)3.06271991
42iron ion import (GO:0097286)2.97840645
43positive regulation of interleukin-2 production (GO:0032743)2.96096831
44regulation of alpha-beta T cell proliferation (GO:0046640)2.94052094
45antigen receptor-mediated signaling pathway (GO:0050851)2.94006878
46nuclear pore organization (GO:0006999)2.93701913
47T cell costimulation (GO:0031295)2.92011007
48insulin-like growth factor receptor signaling pathway (GO:0048009)2.90438692
49lymphocyte homeostasis (GO:0002260)2.89238715
50growth hormone receptor signaling pathway (GO:0060396)2.87841931
51megakaryocyte development (GO:0035855)2.87389966
52T cell receptor signaling pathway (GO:0050852)2.86682138
53leukocyte aggregation (GO:0070486)2.85803314
54lymphocyte costimulation (GO:0031294)2.85596540
55regulation of establishment of cell polarity (GO:2000114)2.85474066
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84672513
57positive regulation of granulocyte differentiation (GO:0030854)2.84398187
58peptidyl-lysine trimethylation (GO:0018023)2.82126792
59B cell homeostasis (GO:0001782)2.82059588
60embryonic hemopoiesis (GO:0035162)2.82000059
61V(D)J recombination (GO:0033151)2.80407293
62cellular response to interleukin-15 (GO:0071350)2.79319872
63positive regulation of keratinocyte differentiation (GO:0045618)2.78735112
64regulation of RNA export from nucleus (GO:0046831)2.78408265
65T cell migration (GO:0072678)2.78358345
66histone lysine demethylation (GO:0070076)2.78113135
67lymph node development (GO:0048535)2.78055304
68positive regulation of tolerance induction (GO:0002645)2.73402063
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72100606
70regulation of necroptotic process (GO:0060544)2.71342908
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69970275
72mitotic sister chromatid cohesion (GO:0007064)2.66131745
73T cell differentiation (GO:0030217)2.65886050
74regulation of establishment or maintenance of cell polarity (GO:0032878)2.63721825
75positive regulation of protein import into nucleus, translocation (GO:0033160)2.63263263
76cellular response to zinc ion (GO:0071294)2.62774181
77alpha-beta T cell activation (GO:0046631)2.62761888
78histone demethylation (GO:0016577)2.61857672
79regulation of T cell receptor signaling pathway (GO:0050856)2.61757873
80B cell proliferation (GO:0042100)2.60061632
81histone H3-K4 methylation (GO:0051568)2.58839721
82T-helper cell differentiation (GO:0042093)2.58738810
83CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58738810
84regulation of response to interferon-gamma (GO:0060330)2.58530855
85histone H3-K9 demethylation (GO:0033169)2.57287558
86negative regulation of T cell mediated immunity (GO:0002710)2.56700153
87positive regulation of mRNA catabolic process (GO:0061014)2.55774351
88hypotonic response (GO:0006971)2.55754310
89regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.55676701
90positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.55676701
91protein K48-linked deubiquitination (GO:0071108)2.54498847
92leukocyte homeostasis (GO:0001776)2.54194295
93peptidyl-lysine methylation (GO:0018022)2.54192809
94regulation of B cell proliferation (GO:0030888)2.53999337
95positive regulation of interferon-alpha production (GO:0032727)2.53460599
96alpha-beta T cell differentiation (GO:0046632)2.53255252
97positive regulation of humoral immune response (GO:0002922)2.53173791
98regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.52701493
99positive regulation of natural killer cell differentiation (GO:0032825)2.52588232
100positive regulation of DNA-templated transcription, initiation (GO:2000144)2.52482377
101negative regulation of phagocytosis (GO:0050765)2.52245220
102regulation of nucleobase-containing compound transport (GO:0032239)2.52151933
103mature B cell differentiation (GO:0002335)2.51602654
104regulation of regulatory T cell differentiation (GO:0045589)2.51211222
105mucosal-associated lymphoid tissue development (GO:0048537)2.49600507
106Peyers patch development (GO:0048541)2.49600507
107natural killer cell differentiation (GO:0001779)2.49582501
108negative regulation of DNA repair (GO:0045738)2.49521250
109lipid translocation (GO:0034204)2.47704234
110phospholipid translocation (GO:0045332)2.47704234
111negative regulation of B cell proliferation (GO:0030889)2.45982392
112positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45433410
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45433410
114regulation of protein polyubiquitination (GO:1902914)2.45221635
115positive regulation of isotype switching (GO:0045830)2.44397637
116positive regulation of protein deacetylation (GO:0090312)2.44118184
117myeloid dendritic cell activation (GO:0001773)2.43969109
118negative regulation of erythrocyte differentiation (GO:0045647)2.43608326
119regulation of interleukin-2 biosynthetic process (GO:0045076)2.43595072
120establishment of protein localization to Golgi (GO:0072600)2.43140974
121cellular response to growth hormone stimulus (GO:0071378)2.42488438
122positive regulation by host of viral transcription (GO:0043923)2.42355521
123regulation of tolerance induction (GO:0002643)2.41584187
124negative regulation of thymocyte apoptotic process (GO:0070244)2.41060774
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.41006537
126cellular extravasation (GO:0045123)2.39654473
127NIK/NF-kappaB signaling (GO:0038061)2.39351518
128positive regulation of B cell activation (GO:0050871)2.38942343
129negative regulation of stress fiber assembly (GO:0051497)2.38509690
130negative regulation of T-helper cell differentiation (GO:0045623)2.37774932
131negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37774932
132regulation of mRNA catabolic process (GO:0061013)2.36767645
133germinal center formation (GO:0002467)2.36616963
134response to type I interferon (GO:0034340)2.35814099
135coronary vasculature morphogenesis (GO:0060977)2.35507960
136natural killer cell activation (GO:0030101)2.34981612
137regulation of granulocyte differentiation (GO:0030852)2.34738509
138pericardium development (GO:0060039)2.32892010
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32745514
140histone mRNA catabolic process (GO:0071044)2.32635428
141T cell lineage commitment (GO:0002360)2.32304516
142CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.31609691
143embryonic camera-type eye morphogenesis (GO:0048596)2.31056986
144striated muscle atrophy (GO:0014891)2.29481782
145regulation of interferon-alpha production (GO:0032647)2.29083551
146angiogenesis involved in wound healing (GO:0060055)2.28853087
147type I interferon signaling pathway (GO:0060337)2.26490421
148cellular response to type I interferon (GO:0071357)2.26490421
149modulation by symbiont of host immune response (GO:0052553)2.25782400
150modulation by symbiont of host defense response (GO:0052031)2.25782400
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25782400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.03848770
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.94025352
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.16399315
4RUNX_20019798_ChIP-Seq_JUKART_Human3.18538008
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15434105
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98524402
7MYC_22102868_ChIP-Seq_BL_Human2.91034509
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90847371
9* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.90215218
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88802928
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.82952707
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80587100
13SCL_19346495_ChIP-Seq_HPC-7_Human2.62478126
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58601201
15MYB_26560356_Chip-Seq_TH2_Human2.37442329
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32843638
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32669842
18GATA1_22025678_ChIP-Seq_K562_Human2.27229763
19E2F7_22180533_ChIP-Seq_HELA_Human2.22974416
20MYB_26560356_Chip-Seq_TH1_Human2.20248113
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15373412
22* MAF_26560356_Chip-Seq_TH1_Human2.11769104
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.08066781
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.07624938
25* TCF7_22412390_ChIP-Seq_EML_Mouse2.07158517
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07089805
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06003956
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98063152
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.96368946
30VDR_21846776_ChIP-Seq_THP-1_Human1.94187480
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93187413
32* UTX_26944678_Chip-Seq_JUKART_Human1.93029418
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.88956570
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86850929
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.83597767
36* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83543043
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81455710
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.79154032
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.76650162
40VDR_24763502_ChIP-Seq_THP-1_Human1.72012617
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.71493147
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70825247
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.70357158
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69555234
45* LXR_22158963_ChIP-Seq_LIVER_Mouse1.66776612
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65712440
47GATA3_27048872_Chip-Seq_THYMUS_Human1.51752064
48* GATA2_21666600_ChIP-Seq_HMVEC_Human1.50628459
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.50194584
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50032232
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44406591
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44033680
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42457372
54* KDM2B_26808549_Chip-Seq_DND41_Human1.40141359
55* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39323163
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.36937219
57* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36082602
58AHR_22903824_ChIP-Seq_MCF-7_Human1.33512323
59VDR_24787735_ChIP-Seq_THP-1_Human1.33231211
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33178937
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30929968
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30020535
63SPI1_23127762_ChIP-Seq_K562_Human1.27791685
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27601117
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26797727
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.26494762
67* PU_27001747_Chip-Seq_BMDM_Mouse1.25918222
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25296288
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25201512
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24765346
71* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23737418
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19821456
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19670009
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19006973
75* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16836251
76* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16772850
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16655469
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16365833
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.15990661
80SPI1_23547873_ChIP-Seq_NB4_Human1.15240917
81* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15010163
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12163457
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11763313
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10276854
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10258559
86* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09764006
87* MAF_26560356_Chip-Seq_TH2_Human1.09287099
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08434795
89AR_21572438_ChIP-Seq_LNCaP_Human1.07801570
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07693341
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07677518
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07553821
93* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06942587
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.06262966
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05985121
96GATA2_19941826_ChIP-Seq_K562_Human1.05723784
97* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03811649
98* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01901729
99GATA1_19941826_ChIP-Seq_K562_Human1.00919177
100GATA3_26560356_Chip-Seq_TH2_Human1.00785643
101* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00615347
102* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00615347
103CLOCK_20551151_ChIP-Seq_293T_Human0.99877886
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98763754
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98450570
106* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98376444
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96715308
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96428519
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95662398
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95655970
111* TP63_23658742_ChIP-Seq_EP156T_Human0.95611450
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93846229
113* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92962971
114TP53_16413492_ChIP-PET_HCT116_Human0.91910114
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89993817
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88824030
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88672544
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88166479
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87727007
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87704784
121* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87700778
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87335377
123BRD4_25478319_ChIP-Seq_HGPS_Human0.86609382
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86217801
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85200443
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83885026
127* TBX20_22080862_ChIP-Seq_HEART_Mouse0.82354273
128* TBX20_22328084_ChIP-Seq_HEART_Mouse0.82354273
129NCOR1_26117541_ChIP-Seq_K562_Human0.82060625
130* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81890839
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.81535160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.98996867
2MP0003763_abnormal_thymus_physiology3.03870091
3MP0002166_altered_tumor_susceptibility3.01319815
4MP0001835_abnormal_antigen_presentation2.65074301
5MP0001800_abnormal_humoral_immune2.62287160
6MP0002396_abnormal_hematopoietic_system2.61698160
7MP0000685_abnormal_immune_system2.57268246
8MP0005387_immune_system_phenotype2.47018045
9MP0001790_abnormal_immune_system2.47018045
10MP0003300_gastrointestinal_ulcer2.40291015
11MP0002006_tumorigenesis2.37434927
12MP0005671_abnormal_response_to2.28669561
13MP0000569_abnormal_digit_pigmentation2.25627541
14MP0004808_abnormal_hematopoietic_stem2.22637798
15MP0002452_abnormal_antigen_presenting2.06331496
16* MP0002398_abnormal_bone_marrow1.98002374
17MP0005360_urolithiasis1.96432183
18MP0003436_decreased_susceptibility_to1.95094946
19MP0002723_abnormal_immune_serum1.94783241
20MP0005000_abnormal_immune_tolerance1.92602126
21MP0002420_abnormal_adaptive_immunity1.89977562
22MP0004947_skin_inflammation1.88924062
23MP0001873_stomach_inflammation1.86753137
24MP0001819_abnormal_immune_cell1.86585042
25MP0003303_peritoneal_inflammation1.80938665
26MP0009278_abnormal_bone_marrow1.80845058
27MP0003724_increased_susceptibility_to1.80377315
28MP0001853_heart_inflammation1.73269449
29MP0005397_hematopoietic_system_phenotyp1.73186901
30MP0001545_abnormal_hematopoietic_system1.73186901
31* MP0000716_abnormal_immune_system1.71827354
32MP0010155_abnormal_intestine_physiology1.71290672
33MP0002405_respiratory_system_inflammati1.69462777
34MP0005310_abnormal_salivary_gland1.68539469
35MP0009785_altered_susceptibility_to1.66685905
36* MP0000689_abnormal_spleen_morphology1.66060575
37MP0001879_abnormal_lymphatic_vessel1.64394469
38MP0002009_preneoplasia1.63409320
39MP0002722_abnormal_immune_system1.63360957
40MP0005451_abnormal_body_composition1.62398341
41* MP0000703_abnormal_thymus_morphology1.62011897
42MP0005025_abnormal_response_to1.60816604
43MP0010352_gastrointestinal_tract_polyps1.54180999
44MP0003705_abnormal_hypodermis_morpholog1.53611486
45MP0010368_abnormal_lymphatic_system1.51538321
46MP0002419_abnormal_innate_immunity1.43867798
47MP0005464_abnormal_platelet_physiology1.42592340
48* MP0002429_abnormal_blood_cell1.42187503
49MP0008961_abnormal_basal_metabolism1.41220293
50MP0004264_abnormal_extraembryonic_tissu1.39665394
51MP0000465_gastrointestinal_hemorrhage1.37511577
52MP0002933_joint_inflammation1.35079715
53MP0010234_abnormal_vibrissa_follicle1.33825281
54MP0001845_abnormal_inflammatory_respons1.30991289
55MP0003191_abnormal_cellular_cholesterol1.30091223
56MP0005365_abnormal_bile_salt1.28615587
57MP0004510_myositis1.28008351
58MP0003828_pulmonary_edema1.25861828
59MP0003252_abnormal_bile_duct1.25336997
60MP0009115_abnormal_fat_cell1.24747420
61MP0006054_spinal_hemorrhage1.24393990
62MP0002138_abnormal_hepatobiliary_system1.23087874
63MP0002148_abnormal_hypersensitivity_rea1.21703640
64MP0000383_abnormal_hair_follicle1.19858193
65MP0002139_abnormal_hepatobiliary_system1.14792438
66MP0001851_eye_inflammation1.13454359
67MP0004381_abnormal_hair_follicle1.13443848
68MP0003045_fibrosis1.12361946
69MP0009333_abnormal_splenocyte_physiolog1.11536128
70MP0003866_abnormal_defecation1.11232516
71MP0000371_diluted_coat_color1.10062937
72MP0002060_abnormal_skin_morphology1.08464050
73MP0003566_abnormal_cell_adhesion1.07059270
74MP0005023_abnormal_wound_healing1.06743116
75MP0003183_abnormal_peptide_metabolism1.06276604
76MP0005076_abnormal_cell_differentiation1.06051200
77MP0000609_abnormal_liver_physiology1.05185417
78MP0003453_abnormal_keratinocyte_physiol1.04831195
79MP0001533_abnormal_skeleton_physiology1.04470284
80MP0005085_abnormal_gallbladder_physiolo1.04204259
81MP0003943_abnormal_hepatobiliary_system1.01942332
82MP0005666_abnormal_adipose_tissue0.99511993
83MP0000767_abnormal_smooth_muscle0.98397288
84MP0004883_abnormal_blood_vessel0.96300664
85MP0002796_impaired_skin_barrier0.95781343
86MP0003091_abnormal_cell_migration0.95101111
87MP0000733_abnormal_muscle_development0.94279104
88MP0008875_abnormal_xenobiotic_pharmacok0.92623628
89MP0010678_abnormal_skin_adnexa0.92271773
90MP0003868_abnormal_feces_composition0.89921581
91MP0001216_abnormal_epidermal_layer0.89540682
92MP0003279_aneurysm0.89417233
93MP0002998_abnormal_bone_remodeling0.88373276
94MP0008469_abnormal_protein_level0.87549898
95MP0006082_CNS_inflammation0.85652222
96MP0002086_abnormal_extraembryonic_tissu0.85430788
97MP0001243_abnormal_dermal_layer0.84614454
98MP0010307_abnormal_tumor_latency0.84512674
99MP0002877_abnormal_melanocyte_morpholog0.84155870
100MP0005164_abnormal_response_to0.83932037
101MP0002254_reproductive_system_inflammat0.83657547
102MP0005621_abnormal_cell_physiology0.83610235
103MP0009764_decreased_sensitivity_to0.83098551
104MP0001348_abnormal_lacrimal_gland0.82708480
105MP0004130_abnormal_muscle_cell0.81551654
106MP0004036_abnormal_muscle_relaxation0.81385405
107MP0005375_adipose_tissue_phenotype0.81284339
108MP0002019_abnormal_tumor_incidence0.79730276
109MP0010329_abnormal_lipoprotein_level0.79016854
110MP0005174_abnormal_tail_pigmentation0.78635841
111MP0003448_altered_tumor_morphology0.78266662
112MP0004185_abnormal_adipocyte_glucose0.78157066
113MP0002095_abnormal_skin_pigmentation0.77579356
114MP0003656_abnormal_erythrocyte_physiolo0.75897005
115MP0005275_abnormal_skin_tensile0.75381686
116MP0002088_abnormal_embryonic_growth/wei0.75020329
117MP0009931_abnormal_skin_appearance0.75000018
118MP0009763_increased_sensitivity_to0.74972015
119MP0000249_abnormal_blood_vessel0.74808489
120MP0002168_other_aberrant_phenotype0.74695954
121MP0002971_abnormal_brown_adipose0.74007437
122MP0000015_abnormal_ear_pigmentation0.73877988
123MP0003221_abnormal_cardiomyocyte_apopto0.73582019
124MP0003984_embryonic_growth_retardation0.73019330
125MP0005670_abnormal_white_adipose0.72980130
126MP0001191_abnormal_skin_condition0.72221482
127MP0002925_abnormal_cardiovascular_devel0.71977891
128MP0005409_darkened_coat_color0.71969323
129MP0010630_abnormal_cardiac_muscle0.70944997
130MP0001784_abnormal_fluid_regulation0.70062688
131MP0000598_abnormal_liver_morphology0.69630641
132MP0001915_intracranial_hemorrhage0.69499294

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.69184040
2T lymphocytopenia (HP:0005403)4.57810897
3Abnormality of T cell number (HP:0011839)4.40036748
4Agammaglobulinemia (HP:0004432)4.26712919
5Thyroiditis (HP:0100646)4.22741743
6Abnormality of B cell number (HP:0010975)4.16115603
7B lymphocytopenia (HP:0010976)4.16115603
8Recurrent viral infections (HP:0004429)4.13537262
9Panhypogammaglobulinemia (HP:0003139)4.00911814
10Severe combined immunodeficiency (HP:0004430)3.77762015
11Recurrent fungal infections (HP:0002841)3.47853014
12Combined immunodeficiency (HP:0005387)3.37192685
13Hypoplasia of the thymus (HP:0000778)3.27471599
14Cellulitis (HP:0100658)3.20690575
15Autoimmune thrombocytopenia (HP:0001973)3.17335297
16Abnormality of T cells (HP:0002843)3.13979088
17Papilloma (HP:0012740)3.10864824
18Verrucae (HP:0200043)3.10864824
19Eosinophilia (HP:0001880)3.07617321
20Recurrent bronchitis (HP:0002837)3.04550059
21Spontaneous hematomas (HP:0007420)3.04375726
22IgM deficiency (HP:0002850)2.97024419
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.95725903
24Subacute progressive viral hepatitis (HP:0006572)2.91522555
25Colitis (HP:0002583)2.89450700
26Chronic otitis media (HP:0000389)2.82072613
27Meningitis (HP:0001287)2.79963637
28Myocardial infarction (HP:0001658)2.73723504
29Abnormality of eosinophils (HP:0001879)2.64546851
30Inflammation of the large intestine (HP:0002037)2.62677642
31Granulocytopenia (HP:0001913)2.61103292
32Mitral stenosis (HP:0001718)2.60743170
33Neonatal hypoglycemia (HP:0001998)2.57516259
34Aortic aneurysm (HP:0004942)2.54050478
35Genetic anticipation (HP:0003743)2.53656225
36Papilledema (HP:0001085)2.53387338
37IgG deficiency (HP:0004315)2.53346198
38Chronic diarrhea (HP:0002028)2.51961213
39Hematochezia (HP:0002573)2.50015028
40Gastrointestinal inflammation (HP:0004386)2.48491268
41Gastrointestinal stroma tumor (HP:0100723)2.47718947
42Viral hepatitis (HP:0006562)2.44054429
43Chronic mucocutaneous candidiasis (HP:0002728)2.43048175
44Recurrent cutaneous fungal infections (HP:0011370)2.43048175
45Acute myeloid leukemia (HP:0004808)2.43020778
46Dysmetric saccades (HP:0000641)2.42471022
47Arterial thrombosis (HP:0004420)2.42147736
48Prolonged bleeding time (HP:0003010)2.40487881
49Myositis (HP:0100614)2.40370854
50Macroorchidism (HP:0000053)2.39088680
51Long eyelashes (HP:0000527)2.37854119
52Gingival bleeding (HP:0000225)2.36603425
53Papillary thyroid carcinoma (HP:0002895)2.35179112
54Lymphopenia (HP:0001888)2.35047273
55Eczematoid dermatitis (HP:0000976)2.33884474
56Overgrowth (HP:0001548)2.33609698
57Leukocytosis (HP:0001974)2.32183965
58Thrombocytosis (HP:0001894)2.31506985
59Abnormal platelet volume (HP:0011876)2.29981024
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28723895
61Vasculitis (HP:0002633)2.28559049
62IgA deficiency (HP:0002720)2.26813825
63Osteomyelitis (HP:0002754)2.23951355
64Ankyloglossia (HP:0010296)2.23363458
65Pustule (HP:0200039)2.22083878
66Coarse hair (HP:0002208)2.21957941
67Impaired platelet aggregation (HP:0003540)2.20717143
68Abnormal platelet function (HP:0011869)2.20717143
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.20211046
70Generalized hypopigmentation of hair (HP:0011358)2.19995275
71Curly hair (HP:0002212)2.17824777
72Periodontitis (HP:0000704)2.17776814
73Abnormality of T cell physiology (HP:0011840)2.16886715
74Fair hair (HP:0002286)2.16748444
75Elevated erythrocyte sedimentation rate (HP:0003565)2.15688263
76Epistaxis (HP:0000421)2.12728532
77Sandal gap (HP:0001852)2.11555407
78Increased mean platelet volume (HP:0011877)2.09244736
79Abnormality of secondary sexual hair (HP:0009888)2.07090657
80Abnormality of the axillary hair (HP:0100134)2.07090657
81Broad face (HP:0000283)2.05907416
82Asymmetry of the thorax (HP:0001555)2.05168389
83Sepsis (HP:0100806)2.05067673
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.04759855
85Osteolytic defects of the hand bones (HP:0009699)2.04759855
86Slow saccadic eye movements (HP:0000514)2.04514326
87Germ cell neoplasia (HP:0100728)2.03898379
88Flat acetabular roof (HP:0003180)2.03677607
89Syringomyelia (HP:0003396)2.03639390
90Spinal cord lesions (HP:0100561)2.03639390
91Depressed nasal tip (HP:0000437)2.03210498
92Abnormality of oral frenula (HP:0000190)2.02926897
93Pulmonary embolism (HP:0002204)2.02840677
94Hyperkalemia (HP:0002153)2.02495877
95Truncal obesity (HP:0001956)2.01055186
96Sparse lateral eyebrow (HP:0005338)2.00315957
97Dislocated radial head (HP:0003083)2.00136603
98Deep venous thrombosis (HP:0002625)1.99782433
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.99780428
100Abnormality of the nasal septum (HP:0000419)1.98642601
101Subaortic stenosis (HP:0001682)1.97233929
102Abnormality of the left ventricular outflow tract (HP:0011103)1.97233929
103Recurrent sinusitis (HP:0011108)1.97035920
104Pulmonary infiltrates (HP:0002113)1.96247239
105Prominent nose (HP:0000448)1.93795031
106Spondylolisthesis (HP:0003302)1.93740409
107Lip pit (HP:0100267)1.93687272
108Calf muscle hypertrophy (HP:0008981)1.93663050
109Orchitis (HP:0100796)1.91369044
110Recurrent skin infections (HP:0001581)1.91332725
111Persistence of primary teeth (HP:0006335)1.91270923
112Abnormality of the nasal mucosa (HP:0000433)1.91207683
113Emphysema (HP:0002097)1.91066209
114Abnormality of the intervertebral disk (HP:0005108)1.90513285
115Gingivitis (HP:0000230)1.88888332
116Heterotopia (HP:0002282)1.88526204
117Autoimmune hemolytic anemia (HP:0001890)1.86925606
118Recurrent bacterial skin infections (HP:0005406)1.84737352
119Retrobulbar optic neuritis (HP:0100654)1.84725834
120Optic neuritis (HP:0100653)1.84725834
121Cutis marmorata (HP:0000965)1.83353261
122Hypoproteinemia (HP:0003075)1.82313138
123Thick nail (HP:0001805)1.81735611
124Encephalitis (HP:0002383)1.81611393
125Increased IgE level (HP:0003212)1.80975018
126Nasal polyposis (HP:0100582)1.80741437
127Gastrointestinal infarctions (HP:0005244)1.80725940
128Fatigue (HP:0012378)1.80381935
129Transitional cell carcinoma of the bladder (HP:0006740)1.80355520
130Volvulus (HP:0002580)1.79817606
131Polycythemia (HP:0001901)1.78986541
132Mediastinal lymphadenopathy (HP:0100721)1.77882430
133Glucose intolerance (HP:0000833)1.77848767
134Keratoconjunctivitis sicca (HP:0001097)1.76888328
135Arterial tortuosity (HP:0005116)1.76439638
136Hepatitis (HP:0012115)1.76151013
137Abnormality of the radial head (HP:0003995)1.75877691
138Bicuspid aortic valve (HP:0001647)1.75688429
139Bladder carcinoma (HP:0002862)1.75602583
140Bladder neoplasm (HP:0009725)1.75602583
141Abnormal glucose tolerance (HP:0001952)1.74831338
142Mitral valve prolapse (HP:0001634)1.74260014
143Conjunctival telangiectasia (HP:0000524)1.73394851
144Deep philtrum (HP:0002002)1.73375563
145Limited elbow extension (HP:0001377)1.72821259
146Narrow palate (HP:0000189)1.72686487
147Stomatitis (HP:0010280)1.70988816
148Skin ulcer (HP:0200042)1.70709372
149Ectropion (HP:0000656)1.70633156
150Neoplasm of the tracheobronchial system (HP:0100552)1.70511313
151Aortic dissection (HP:0002647)1.70483227
152Muscle hypertrophy of the lower extremities (HP:0008968)1.68635316
153Advanced eruption of teeth (HP:0006288)1.67914662
154Recurrent abscess formation (HP:0002722)1.67090129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.17861534
2TXK2.99120745
3AKT32.89609082
4MAP3K102.64614544
5CDK122.36638330
6MAP3K142.28284174
7FGFR32.24860406
8PRPF4B2.20959065
9STK102.18123330
10JAK32.14498186
11FGFR42.07788323
12TYK21.94480841
13INSRR1.92387823
14EEF2K1.88663283
15JAK11.80621189
16TGFBR21.73407581
17ERN11.72207385
18ITK1.71717617
19SIK11.62673672
20IKBKE1.61785213
21NLK1.61019230
22CAMK1D1.58014402
23LATS11.56777284
24MAP3K21.55603831
25RIPK41.53764374
26EPHB11.51418469
27ZAP701.49737016
28GRK61.47128004
29WNK11.41644376
30FRK1.41604853
31MAP3K131.39921053
32FGFR21.38531029
33CHUK1.37701004
34TEC1.35351600
35PIM11.33779975
36MAP3K71.33148104
37BTK1.28268483
38NUAK11.27358670
39IKBKB1.24119211
40CDK91.23410757
41CSK1.22169340
42STK31.21974242
43SYK1.21260522
44DMPK1.20961869
45CSF1R1.20837926
46STK41.18566884
47PIK3CG1.15120414
48HCK1.13243166
49TAOK31.12507504
50CAMK1G1.11478500
51TBK11.10289138
52EPHA31.09367326
53CAMKK21.08221368
54NEK91.08070117
55LRRK21.07827674
56LCK1.04945868
57KIT1.04161358
58PDGFRB1.03460057
59RPS6KA41.02500352
60STK241.01864309
61YES11.01341995
62TIE11.01069318
63CDK61.00483193
64SMG10.98640576
65PRKCQ0.96755536
66TRPM70.96471510
67BMPR20.95356060
68MARK30.94538742
69TTN0.94177423
70SGK30.93727241
71MAP2K30.93366090
72BRD40.93240967
73JAK20.91187237
74PKN20.90294057
75MAPK70.89160449
76CDK40.86602017
77PDGFRA0.85911500
78ICK0.85381963
79CDC42BPA0.84791212
80ZAK0.82525806
81PTK60.81724710
82NEK60.81437185
83MAP3K30.78176961
84TRIB30.77927918
85STK380.75382542
86MELK0.74626109
87TAF10.74567856
88SGK20.74172545
89MST40.73741589
90SGK2230.73566108
91SGK4940.73566108
92PDK10.71435595
93MAPK120.69325375
94TGFBR10.69238992
95SCYL20.67874551
96HIPK20.67671255
97PRKAA20.66107367
98PRKCH0.63931789
99FES0.62922343
100MAPK110.62251352
101RPS6KB20.61774087
102IRAK30.60681623
103SIK30.60360896
104IRAK10.59188953
105LYN0.58467607
106EIF2AK30.57552553
107RET0.57491750
108IRAK40.55570954
109SIK20.54471675
110MTOR0.52493154
111PRKD20.51564715
112RPS6KA50.51243126
113PIK3CA0.50917715
114CLK10.50863432
115MARK20.49728700
116TNK20.49588707
117MAP3K10.49548128
118RPS6KB10.48859863
119MAPK40.48792872
120RIPK10.48347614
121BLK0.48122208
122ABL10.47699805
123KSR20.46779223
124SGK10.45497446
125FLT30.43260640
126KDR0.41856546
127TAOK10.39987877
128PRKD10.35566573
129NEK20.34124956
130EGFR0.33235431

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.18137673
2B cell receptor signaling pathway_Homo sapiens_hsa046622.59541136
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.47573342
4T cell receptor signaling pathway_Homo sapiens_hsa046602.23053872
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.15899054
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05275098
7Osteoclast differentiation_Homo sapiens_hsa043801.90478884
8Measles_Homo sapiens_hsa051621.90385834
9Hematopoietic cell lineage_Homo sapiens_hsa046401.86062494
10Lysine degradation_Homo sapiens_hsa003101.74313864
11Jak-STAT signaling pathway_Homo sapiens_hsa046301.71354303
12Leishmaniasis_Homo sapiens_hsa051401.64871628
13Caffeine metabolism_Homo sapiens_hsa002321.56892215
14Acute myeloid leukemia_Homo sapiens_hsa052211.55335669
15Staphylococcus aureus infection_Homo sapiens_hsa051501.53317901
16Chronic myeloid leukemia_Homo sapiens_hsa052201.50931835
17Thyroid cancer_Homo sapiens_hsa052161.48217666
18Toxoplasmosis_Homo sapiens_hsa051451.48097841
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44854167
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41438790
21Viral myocarditis_Homo sapiens_hsa054161.39321657
22Hepatitis B_Homo sapiens_hsa051611.35773965
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.35689064
24Antigen processing and presentation_Homo sapiens_hsa046121.34917572
25Pancreatic cancer_Homo sapiens_hsa052121.33340505
26Non-homologous end-joining_Homo sapiens_hsa034501.31955107
27Herpes simplex infection_Homo sapiens_hsa051681.31954087
28Small cell lung cancer_Homo sapiens_hsa052221.31361099
29Complement and coagulation cascades_Homo sapiens_hsa046101.30438325
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29572572
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.26109455
32Glioma_Homo sapiens_hsa052141.21323498
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20770540
34* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20571281
35Platelet activation_Homo sapiens_hsa046111.20043009
36TNF signaling pathway_Homo sapiens_hsa046681.19189040
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17591179
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15978560
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12550766
40Insulin resistance_Homo sapiens_hsa049311.09742842
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09028624
42Choline metabolism in cancer_Homo sapiens_hsa052311.09008655
43Malaria_Homo sapiens_hsa051441.08452355
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08113124
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07142230
46Influenza A_Homo sapiens_hsa051641.05589082
47MicroRNAs in cancer_Homo sapiens_hsa052061.02498373
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99770784
49ErbB signaling pathway_Homo sapiens_hsa040120.99621887
50Adherens junction_Homo sapiens_hsa045200.98366643
51FoxO signaling pathway_Homo sapiens_hsa040680.98222976
52Chemokine signaling pathway_Homo sapiens_hsa040620.98115597
53Nitrogen metabolism_Homo sapiens_hsa009100.97834578
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97367332
55Allograft rejection_Homo sapiens_hsa053300.97171008
56Apoptosis_Homo sapiens_hsa042100.94879085
57Prostate cancer_Homo sapiens_hsa052150.94521328
58Viral carcinogenesis_Homo sapiens_hsa052030.93374323
59Prolactin signaling pathway_Homo sapiens_hsa049170.92744405
60Systemic lupus erythematosus_Homo sapiens_hsa053220.92600293
61Circadian rhythm_Homo sapiens_hsa047100.91786614
62* HTLV-I infection_Homo sapiens_hsa051660.90638173
63ABC transporters_Homo sapiens_hsa020100.89568589
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.89080746
65Type II diabetes mellitus_Homo sapiens_hsa049300.88519300
66Non-small cell lung cancer_Homo sapiens_hsa052230.87690056
67Type I diabetes mellitus_Homo sapiens_hsa049400.87319831
68Hepatitis C_Homo sapiens_hsa051600.86510635
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85772087
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84541745
71Graft-versus-host disease_Homo sapiens_hsa053320.79814516
72PPAR signaling pathway_Homo sapiens_hsa033200.79680340
73Insulin signaling pathway_Homo sapiens_hsa049100.79446715
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.78146903
75Focal adhesion_Homo sapiens_hsa045100.73523658
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.73082620
77Fatty acid degradation_Homo sapiens_hsa000710.72646751
78Melanoma_Homo sapiens_hsa052180.72175831
79HIF-1 signaling pathway_Homo sapiens_hsa040660.71997027
80Proteoglycans in cancer_Homo sapiens_hsa052050.71633733
81Dorso-ventral axis formation_Homo sapiens_hsa043200.66600095
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.66246008
83Shigellosis_Homo sapiens_hsa051310.65657865
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65588448
85Notch signaling pathway_Homo sapiens_hsa043300.65303500
86GnRH signaling pathway_Homo sapiens_hsa049120.64471665
87Estrogen signaling pathway_Homo sapiens_hsa049150.64060183
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63991668
89Tryptophan metabolism_Homo sapiens_hsa003800.63318599
90Tuberculosis_Homo sapiens_hsa051520.62683303
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61431540
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61030870
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59861766
94Bladder cancer_Homo sapiens_hsa052190.59086731
95Autoimmune thyroid disease_Homo sapiens_hsa053200.58129375
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58112740
97Arginine biosynthesis_Homo sapiens_hsa002200.58011245
98* MAPK signaling pathway_Homo sapiens_hsa040100.57532233
99Fatty acid biosynthesis_Homo sapiens_hsa000610.57277840
100Long-term potentiation_Homo sapiens_hsa047200.56882406
101Endometrial cancer_Homo sapiens_hsa052130.56762885
102Colorectal cancer_Homo sapiens_hsa052100.55548184
103AMPK signaling pathway_Homo sapiens_hsa041520.55053845
104ECM-receptor interaction_Homo sapiens_hsa045120.53421413
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.52496910
106Asthma_Homo sapiens_hsa053100.50517481
107Pertussis_Homo sapiens_hsa051330.48194161
108Pathways in cancer_Homo sapiens_hsa052000.48085569
109mTOR signaling pathway_Homo sapiens_hsa041500.44143000
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44057027
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43640131
112Epstein-Barr virus infection_Homo sapiens_hsa051690.43155316
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42854958
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.42420511
115Amoebiasis_Homo sapiens_hsa051460.42368391
116Renal cell carcinoma_Homo sapiens_hsa052110.42363508
117p53 signaling pathway_Homo sapiens_hsa041150.41984961
118Inositol phosphate metabolism_Homo sapiens_hsa005620.40818235
119Legionellosis_Homo sapiens_hsa051340.40027021
120Chemical carcinogenesis_Homo sapiens_hsa052040.39839636
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39837784
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39530549
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39085868
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38750344
125VEGF signaling pathway_Homo sapiens_hsa043700.38036793
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37627471

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