ELL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.35452013
2response to peptidoglycan (GO:0032494)5.08175483
3positive regulation by symbiont of host defense response (GO:0052509)5.05893793
4modulation by symbiont of host defense response (GO:0052031)5.05893793
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.05893793
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.05893793
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.05893793
8modulation by symbiont of host immune response (GO:0052553)5.05893793
9cellular ketone body metabolic process (GO:0046950)5.05344059
10positive regulation of gamma-delta T cell activation (GO:0046645)4.85382795
11negative regulation of cell killing (GO:0031342)4.79405598
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.79405598
13L-phenylalanine catabolic process (GO:0006559)4.74455917
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.74455917
15L-phenylalanine metabolic process (GO:0006558)4.73108725
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.73108725
17complement activation, alternative pathway (GO:0006957)4.70721438
18kynurenine metabolic process (GO:0070189)4.64504995
19macrophage activation involved in immune response (GO:0002281)4.59676052
20sulfur amino acid catabolic process (GO:0000098)4.58963783
21aromatic amino acid family catabolic process (GO:0009074)4.52626860
22negative regulation of fibrinolysis (GO:0051918)4.49598079
23negative regulation of interleukin-12 production (GO:0032695)4.45818329
24urea cycle (GO:0000050)4.43426498
25urea metabolic process (GO:0019627)4.43426498
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39450519
27alpha-linolenic acid metabolic process (GO:0036109)4.37928094
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35354705
29regulation of protein activation cascade (GO:2000257)4.34067211
30tryptophan catabolic process (GO:0006569)4.33502701
31indole-containing compound catabolic process (GO:0042436)4.33502701
32indolalkylamine catabolic process (GO:0046218)4.33502701
33detection of other organism (GO:0098543)4.31360161
34protein carboxylation (GO:0018214)4.31080879
35peptidyl-glutamic acid carboxylation (GO:0017187)4.31080879
36neutrophil activation involved in immune response (GO:0002283)4.30395264
37ketone body metabolic process (GO:1902224)4.25690382
38antigen processing and presentation of endogenous antigen (GO:0019883)4.18400117
39regulation of cholesterol homeostasis (GO:2000188)4.12249741
40detection of bacterium (GO:0016045)4.11255038
41high-density lipoprotein particle remodeling (GO:0034375)4.09514726
42regulation of complement activation (GO:0030449)4.06964097
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.05630667
44negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.04462358
45tryptophan metabolic process (GO:0006568)4.03722135
46phospholipid efflux (GO:0033700)4.02245838
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01466303
48nitrogen cycle metabolic process (GO:0071941)3.98723590
49regulation of fibrinolysis (GO:0051917)3.97577193
50response to muramyl dipeptide (GO:0032495)3.95343716
51homocysteine metabolic process (GO:0050667)3.94177539
52regulation of interferon-beta biosynthetic process (GO:0045357)3.90077174
53plasma lipoprotein particle clearance (GO:0034381)3.87742942
54detection of molecule of bacterial origin (GO:0032490)3.87273678
55germinal center formation (GO:0002467)3.82672720
56negative regulation of sterol transport (GO:0032372)3.81459313
57negative regulation of cholesterol transport (GO:0032375)3.81459313
58cellular extravasation (GO:0045123)3.78584866
59regulation of triglyceride catabolic process (GO:0010896)3.78113983
60negative regulation of erythrocyte differentiation (GO:0045647)3.77510631
61detection of external biotic stimulus (GO:0098581)3.76176210
62glyoxylate metabolic process (GO:0046487)3.74970854
63cysteine metabolic process (GO:0006534)3.73919755
64protoporphyrinogen IX biosynthetic process (GO:0006782)3.73880774
65immunoglobulin mediated immune response (GO:0016064)3.73302285
66acylglycerol homeostasis (GO:0055090)3.72804102
67triglyceride homeostasis (GO:0070328)3.72804102
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.72769394
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.71189633
70bile acid biosynthetic process (GO:0006699)3.69717492
71plasma lipoprotein particle assembly (GO:0034377)3.67690816
72regulation of gamma-delta T cell activation (GO:0046643)3.66209291
73cellular response to type I interferon (GO:0071357)3.59666125
74type I interferon signaling pathway (GO:0060337)3.59666125
75regulation of cholesterol esterification (GO:0010872)3.59199697
76reverse cholesterol transport (GO:0043691)3.59046033
77response to type I interferon (GO:0034340)3.56917689
78leukocyte aggregation (GO:0070486)3.54947545
79serine family amino acid catabolic process (GO:0009071)3.54766957
80NIK/NF-kappaB signaling (GO:0038061)3.51470026
81protein-lipid complex assembly (GO:0065005)3.49652754
82protein-lipid complex remodeling (GO:0034368)3.48459136
83macromolecular complex remodeling (GO:0034367)3.48459136
84plasma lipoprotein particle remodeling (GO:0034369)3.48459136
85glycine metabolic process (GO:0006544)3.47614523
86regulation of T-helper 2 cell differentiation (GO:0045628)3.45596974
87low-density lipoprotein particle clearance (GO:0034383)3.41440009
88regulation of B cell receptor signaling pathway (GO:0050855)3.39174474
89positive regulation of fatty acid beta-oxidation (GO:0032000)3.38756804
90response to host immune response (GO:0052572)3.37157821
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37157821
92amino-acid betaine metabolic process (GO:0006577)3.36971461
93bile acid metabolic process (GO:0008206)3.35386047
94lysine metabolic process (GO:0006553)3.34279767
95lysine catabolic process (GO:0006554)3.34279767
96detection of biotic stimulus (GO:0009595)3.33155737
97granulocyte activation (GO:0036230)3.30849218
98cholesterol efflux (GO:0033344)3.28292926
99neutrophil activation (GO:0042119)3.26393063
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25603144
101fibrinolysis (GO:0042730)3.24740974
102negative regulation of fatty acid biosynthetic process (GO:0045717)3.24094866
103aromatic amino acid family metabolic process (GO:0009072)3.23009342
104acute-phase response (GO:0006953)3.22969637
105defense response to protozoan (GO:0042832)3.22259570
106response to host (GO:0075136)3.21538483
107response to host defenses (GO:0052200)3.21538483
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21538483
109regulation of bile acid biosynthetic process (GO:0070857)3.21316559
110macrophage activation (GO:0042116)3.20544532
111valine metabolic process (GO:0006573)3.20055137
112protoporphyrinogen IX metabolic process (GO:0046501)3.19932091
113regulation of mast cell degranulation (GO:0043304)3.19491410
114negative regulation of cytokine production involved in immune response (GO:0002719)3.18724349
115myeloid cell activation involved in immune response (GO:0002275)3.18180383
116positive regulation of lipid catabolic process (GO:0050996)3.18052918
117regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15147571
118interferon-gamma-mediated signaling pathway (GO:0060333)3.14597294
119regulation of fatty acid beta-oxidation (GO:0031998)3.12966906
120phospholipid homeostasis (GO:0055091)3.12670059
121regulation of interferon-alpha production (GO:0032647)3.12410201
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11387260
123regulation of cholesterol storage (GO:0010885)3.10428467
124response to protozoan (GO:0001562)3.08910711
125positive regulation of interferon-alpha production (GO:0032727)3.06849755
126complement activation (GO:0006956)3.06804793
127cholesterol homeostasis (GO:0042632)3.06621385
128negative regulation of lymphocyte mediated immunity (GO:0002707)3.06133426
129alpha-amino acid catabolic process (GO:1901606)3.04036131
130respiratory burst (GO:0045730)3.03710602
131complement activation, classical pathway (GO:0006958)3.02246062
132sterol homeostasis (GO:0055092)3.01707579
133response to growth hormone (GO:0060416)3.01672227
134bile acid and bile salt transport (GO:0015721)3.01173724
135T-helper 1 type immune response (GO:0042088)2.99750723
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99549007
137negative regulation of T cell mediated immunity (GO:0002710)2.97219835
138plasma lipoprotein particle organization (GO:0071827)2.96943110
139protein activation cascade (GO:0072376)2.96272964
140positive regulation of triglyceride lipase activity (GO:0061365)2.95699059
141positive regulation of lipoprotein lipase activity (GO:0051006)2.95699059
142regulation of leukocyte degranulation (GO:0043300)2.93584877
143positive regulation of fatty acid biosynthetic process (GO:0045723)2.92358950
144myeloid dendritic cell differentiation (GO:0043011)2.92095126
145negative regulation of leukocyte mediated immunity (GO:0002704)2.91905318
146regulation of gamma-delta T cell differentiation (GO:0045586)2.91307167
147protein-lipid complex subunit organization (GO:0071825)2.91033765
148serine family amino acid metabolic process (GO:0009069)2.90904977
149positive regulation of type 2 immune response (GO:0002830)2.89162674
150ethanol oxidation (GO:0006069)2.89079236
151lipoprotein metabolic process (GO:0042157)2.88926079
152neutrophil mediated immunity (GO:0002446)2.88857164
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87832145
154cellular zinc ion homeostasis (GO:0006882)2.87731431
155regulation of mast cell activation involved in immune response (GO:0033006)2.87515671
156vitamin transmembrane transport (GO:0035461)2.87456465
157positive regulation of triglyceride metabolic process (GO:0090208)2.86500683
158negative regulation of interleukin-6 production (GO:0032715)2.86370980
159microglial cell activation (GO:0001774)2.86232918
160positive regulation of cellular amide metabolic process (GO:0034250)2.85563338
161very-low-density lipoprotein particle assembly (GO:0034379)2.85533421
162indolalkylamine metabolic process (GO:0006586)2.83920045
163regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83910842
164tyrosine metabolic process (GO:0006570)2.82895084
165serine family amino acid biosynthetic process (GO:0009070)2.81765993
166regulation of T cell tolerance induction (GO:0002664)2.81715974
167cellular amino acid catabolic process (GO:0009063)2.81320052
168pentose-phosphate shunt (GO:0006098)2.80991893
169regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79343514
170B cell mediated immunity (GO:0019724)2.78419410
171cytolysis (GO:0019835)2.77171696
172positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75973061
173regulation of T-helper 1 cell differentiation (GO:0045625)2.75860820
174T cell migration (GO:0072678)2.75187403
175intestinal cholesterol absorption (GO:0030299)2.74347408
176negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74158018
177imidazole-containing compound metabolic process (GO:0052803)2.73471147
178response to interleukin-15 (GO:0070672)2.71791447
179coenzyme catabolic process (GO:0009109)2.71427153
180regulation of type 2 immune response (GO:0002828)2.70727151
181amine catabolic process (GO:0009310)2.69689889
182cellular biogenic amine catabolic process (GO:0042402)2.69689889
183negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69269966
184negative regulation of lipid transport (GO:0032369)2.68895323
185regulation of vitamin D biosynthetic process (GO:0060556)2.68278822
186negative regulation of innate immune response (GO:0045824)2.67980224
187myeloid dendritic cell activation (GO:0001773)2.67957614
188production of molecular mediator involved in inflammatory response (GO:0002532)2.66558216
189B cell receptor signaling pathway (GO:0050853)2.65367600
190regulation of tolerance induction (GO:0002643)2.64874836
191positive regulation of Cdc42 GTPase activity (GO:0043089)2.63016636
192regulation of necroptotic process (GO:0060544)2.61689666
193regulation of antigen processing and presentation (GO:0002577)2.59975202
194tolerance induction (GO:0002507)2.59490363
195positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59251034
196JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58751388
197myeloid leukocyte activation (GO:0002274)2.58644802
198positive regulation of B cell differentiation (GO:0045579)2.57122879
199negative regulation of type 2 immune response (GO:0002829)2.56876960
200positive regulation of interferon-beta production (GO:0032728)2.56157385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38149211
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.72045714
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44728457
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.61566704
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56696104
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.15692725
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12265259
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87231261
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.61777061
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36808716
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33732668
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17780812
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16771905
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13909771
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08077460
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06844969
17MYC_22102868_ChIP-Seq_BL_Human2.06640299
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05836773
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05696400
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05171587
21SPI1_23547873_ChIP-Seq_NB4_Human2.01139484
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.99744587
23SPI1_23127762_ChIP-Seq_K562_Human1.97912117
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90745883
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90277610
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89924257
27RUNX_20019798_ChIP-Seq_JUKART_Human1.87659017
28* VDR_21846776_ChIP-Seq_THP-1_Human1.87310988
29CLOCK_20551151_ChIP-Seq_293T_Human1.83505338
30SCL_19346495_ChIP-Seq_HPC-7_Human1.81032589
31* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78987164
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.72571812
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71510599
34MYB_26560356_Chip-Seq_TH2_Human1.71161042
35TCF7_22412390_ChIP-Seq_EML_Mouse1.68788487
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.68786596
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68367110
38LXR_22292898_ChIP-Seq_THP-1_Human1.62852225
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56308863
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.52977075
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.49545034
42E2F7_22180533_ChIP-Seq_HELA_Human1.49175427
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48596178
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48332749
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46870568
46RACK7_27058665_Chip-Seq_MCF-7_Human1.45203652
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42804576
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38164770
49* VDR_24787735_ChIP-Seq_THP-1_Human1.38161917
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.37206905
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37181759
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36751221
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34381463
54* KDM2B_26808549_Chip-Seq_JURKAT_Human1.33898322
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31756256
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.31404621
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29954399
58KDM2B_26808549_Chip-Seq_DND41_Human1.29667208
59MAF_26560356_Chip-Seq_TH1_Human1.28434824
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27409003
61UTX_26944678_Chip-Seq_JUKART_Human1.25588872
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25445388
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25199466
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23868521
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23543382
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23428331
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22756137
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20190026
69* ATF3_27146783_Chip-Seq_COLON_Human1.18237192
70PU_27001747_Chip-Seq_BMDM_Mouse1.17480568
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16239588
72KDM2B_26808549_Chip-Seq_K562_Human1.15878002
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15755637
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15167666
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15104107
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14502596
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14362632
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14204666
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13774261
80GATA1_19941826_ChIP-Seq_K562_Human1.12713149
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12413581
82GATA1_22025678_ChIP-Seq_K562_Human1.11078908
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10113751
84BCOR_27268052_Chip-Seq_Bcells_Human1.09696923
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08668927
86* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08186950
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07478391
88GATA3_27048872_Chip-Seq_THYMUS_Human1.07391229
89* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07318073
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06118602
91NCOR1_26117541_ChIP-Seq_K562_Human1.05977418
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04891928
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03450289
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03183510
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02992168
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02654922
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.01904204
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01810111
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.01505742
100* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01109733
101MAF_26560356_Chip-Seq_TH2_Human1.00649167
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.00323951
103MYB_26560356_Chip-Seq_TH1_Human1.00175433
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00146870
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99822075
106* P68_20966046_ChIP-Seq_HELA_Human0.99133500
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.97528998
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94952654
109* VDR_24763502_ChIP-Seq_THP-1_Human0.94838698
110RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94465868
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93962504
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93663046
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93279685
114BCL6_27268052_Chip-Seq_Bcells_Human0.92149346
115* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91956436
116GATA6_25053715_ChIP-Seq_YYC3_Human0.89689293
117* ELF1_20517297_ChIP-Seq_JURKAT_Human0.89579334
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89322921
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.88511941
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88446153
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.88333573
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88288791
123* TFEB_21752829_ChIP-Seq_HELA_Human0.88285932
124* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88259127
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88094586
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.87868020
127CREB1_26743006_Chip-Seq_LNCaP_Human0.87581093
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87363890
129* CTCF_21964334_Chip-Seq_Bcells_Human0.87357029
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86058804
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.85895409
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85100901
133* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85004559
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.84545180
135* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83502068
136ZNF263_19887448_ChIP-Seq_K562_Human0.83442326
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83282286
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83081621
139TP53_22127205_ChIP-Seq_IMR90_Human0.82669803
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82490431
141TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82264471
142IRF8_21731497_ChIP-ChIP_J774_Mouse0.82168299
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82149259
144CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81911863
145* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81762182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.97887059
2MP0002139_abnormal_hepatobiliary_system4.86943838
3MP0005365_abnormal_bile_salt4.18190565
4MP0005085_abnormal_gallbladder_physiolo3.84293687
5MP0009840_abnormal_foam_cell3.51977345
6MP0003806_abnormal_nucleotide_metabolis3.14070755
7MP0008875_abnormal_xenobiotic_pharmacok3.13898345
8MP0003705_abnormal_hypodermis_morpholog2.76769176
9MP0005000_abnormal_immune_tolerance2.68143496
10MP0003191_abnormal_cellular_cholesterol2.66044389
11MP0010329_abnormal_lipoprotein_level2.59065781
12MP0003252_abnormal_bile_duct2.48836025
13MP0005671_abnormal_response_to2.46464744
14MP0002148_abnormal_hypersensitivity_rea2.44706025
15MP0000609_abnormal_liver_physiology2.17198614
16MP0005058_abnormal_lysosome_morphology2.15720890
17MP0002420_abnormal_adaptive_immunity2.13147093
18MP0001819_abnormal_immune_cell2.12018944
19MP0008260_abnormal_autophagy2.10641213
20MP0003763_abnormal_thymus_physiology1.92349951
21MP0005083_abnormal_biliary_tract1.90328888
22MP0003436_decreased_susceptibility_to1.89884760
23MP0003172_abnormal_lysosome_physiology1.78112745
24MP0001666_abnormal_nutrient_absorption1.77535687
25MP0005670_abnormal_white_adipose1.70101487
26MP0004185_abnormal_adipocyte_glucose1.69893523
27MP0003828_pulmonary_edema1.65752113
28MP0005332_abnormal_amino_acid1.65608640
29MP0000716_abnormal_immune_system1.62128075
30MP0002118_abnormal_lipid_homeostasis1.58457655
31MP0000858_altered_metastatic_potential1.53925050
32MP0002998_abnormal_bone_remodeling1.51884723
33MP0005319_abnormal_enzyme/_coenzyme1.47923529
34MP0005451_abnormal_body_composition1.43550775
35MP0004264_abnormal_extraembryonic_tissu1.42088027
36MP0003303_peritoneal_inflammation1.37206148
37MP0005310_abnormal_salivary_gland1.37179628
38MP0005076_abnormal_cell_differentiation1.34219241
39MP0001873_stomach_inflammation1.33397288
40MP0002429_abnormal_blood_cell1.30840784
41MP0009278_abnormal_bone_marrow1.30353432
42MP0004019_abnormal_vitamin_homeostasis1.28863465
43MP0000598_abnormal_liver_morphology1.24397195
44MP0008004_abnormal_stomach_pH1.24165586
45MP0003724_increased_susceptibility_to1.22881258
46MP0003448_altered_tumor_morphology1.19936686
47MP0004947_skin_inflammation1.19619778
48MP0003566_abnormal_cell_adhesion1.19287064
49MP0002138_abnormal_hepatobiliary_system1.18986068
50MP0002132_abnormal_respiratory_system1.18235112
51MP0005023_abnormal_wound_healing1.16636633
52MP0003656_abnormal_erythrocyte_physiolo1.15810586
53MP0002332_abnormal_exercise_endurance1.14029532
54MP0003091_abnormal_cell_migration1.13294577
55MP0005666_abnormal_adipose_tissue1.13026584
56MP0003300_gastrointestinal_ulcer1.11995744
57MP0000703_abnormal_thymus_morphology1.11547597
58MP0001851_eye_inflammation1.11209930
59MP0005397_hematopoietic_system_phenotyp1.10287318
60MP0001545_abnormal_hematopoietic_system1.10287318
61MP0010352_gastrointestinal_tract_polyps1.09227867
62MP0010155_abnormal_intestine_physiology1.09210383
63MP0005464_abnormal_platelet_physiology1.09045626
64MP0004808_abnormal_hematopoietic_stem1.08788481
65MP0002970_abnormal_white_adipose1.08560606
66MP0002971_abnormal_brown_adipose1.08008603
67MP0003183_abnormal_peptide_metabolism1.07222893
68MP0009115_abnormal_fat_cell1.05658927
69MP0005164_abnormal_response_to1.04421062
70MP0005584_abnormal_enzyme/coenzyme_acti1.03837849
71MP0009763_increased_sensitivity_to1.03313203
72MP0004883_abnormal_blood_vessel1.02987271
73MP0009643_abnormal_urine_homeostasis1.01810134
74MP0008469_abnormal_protein_level1.01380758
75MP0005390_skeleton_phenotype1.00262032
76MP0003453_abnormal_keratinocyte_physiol0.98366102
77MP0000490_abnormal_crypts_of0.96513338
78MP0002060_abnormal_skin_morphology0.96340547
79MP0000685_abnormal_immune_system0.96328875
80MP0008961_abnormal_basal_metabolism0.95911034
81MP0010368_abnormal_lymphatic_system0.93848836
82MP0002405_respiratory_system_inflammati0.92483463
83MP0002796_impaired_skin_barrier0.92175042
84MP0003195_calcinosis0.91829613
85MP0001845_abnormal_inflammatory_respons0.90381360
86MP0002933_joint_inflammation0.88294983
87MP0002254_reproductive_system_inflammat0.88218003
88MP0001533_abnormal_skeleton_physiology0.88213392
89MP0006082_CNS_inflammation0.87731263
90MP0000604_amyloidosis0.87538841
91MP0005334_abnormal_fat_pad0.86849008
92MP0003718_maternal_effect0.86664343
93MP0003075_altered_response_to0.86453585
94MP0004381_abnormal_hair_follicle0.86123037
95MP0003866_abnormal_defecation0.84673445
96MP0005375_adipose_tissue_phenotype0.84659931
97MP0003690_abnormal_glial_cell0.84387582
98MP0002419_abnormal_innate_immunity0.83421787
99MP0001800_abnormal_humoral_immune0.82951733
100MP0009764_decreased_sensitivity_to0.80669458
101MP0005166_decreased_susceptibility_to0.80587732
102MP0001243_abnormal_dermal_layer0.80171401
103MP0002166_altered_tumor_susceptibility0.78052582
104MP0000689_abnormal_spleen_morphology0.77281175
105MP0005025_abnormal_response_to0.77042962
106MP0004130_abnormal_muscle_cell0.76966373
107MP0003221_abnormal_cardiomyocyte_apopto0.75950885
108MP0001663_abnormal_digestive_system0.75644781
109MP0003186_abnormal_redox_activity0.75453336
110MP0000343_altered_response_to0.74939476
111MP0002877_abnormal_melanocyte_morpholog0.74667776
112MP0000249_abnormal_blood_vessel0.74359775
113MP0003795_abnormal_bone_structure0.74085198
114MP0003045_fibrosis0.74046791
115MP0002723_abnormal_immune_serum0.73999004
116MP0009785_altered_susceptibility_to0.73501672
117MP0010234_abnormal_vibrissa_follicle0.73235022
118MP0009642_abnormal_blood_homeostasis0.72991569
119MP0009333_abnormal_splenocyte_physiolog0.72339521
120MP0005387_immune_system_phenotype0.72099938
121MP0001790_abnormal_immune_system0.72099938
122MP0002396_abnormal_hematopoietic_system0.71608994
123MP0001835_abnormal_antigen_presentation0.71000422
124MP0004858_abnormal_nervous_system0.70664765
125MP0004510_myositis0.70297144
126MP0002277_abnormal_respiratory_mucosa0.70296364
127MP0000477_abnormal_intestine_morphology0.69932349
128MP0001853_heart_inflammation0.69514883
129MP0008874_decreased_physiological_sensi0.69174599
130MP0002722_abnormal_immune_system0.67700832
131MP0001542_abnormal_bone_strength0.67549274
132MP0000465_gastrointestinal_hemorrhage0.67523396
133MP0003011_delayed_dark_adaptation0.66761747
134MP0002019_abnormal_tumor_incidence0.66156347
135MP0008873_increased_physiological_sensi0.66151076
136MP0002452_abnormal_antigen_presenting0.65951504
137MP0003693_abnormal_embryo_hatching0.65644532
138MP0001764_abnormal_homeostasis0.65518966
139MP0005167_abnormal_blood-brain_barrier0.65300040
140MP0005395_other_phenotype0.64418177
141MP0005501_abnormal_skin_physiology0.64155324
142MP0002078_abnormal_glucose_homeostasis0.63777893
143MP0002398_abnormal_bone_marrow0.63192288
144MP0009765_abnormal_xenobiotic_induced0.62151140
145MP0003279_aneurysm0.59887240
146MP0001849_ear_inflammation0.57897948
147MP0006054_spinal_hemorrhage0.57183388

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.84514952
2Pustule (HP:0200039)5.54492369
3Xanthomatosis (HP:0000991)5.04642629
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01224453
5Recurrent bacterial skin infections (HP:0005406)4.94519223
6Abnormality of macrophages (HP:0004311)4.93319028
7Recurrent abscess formation (HP:0002722)4.88716229
8Orchitis (HP:0100796)4.83952333
9Myositis (HP:0100614)4.81136209
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.56498202
11Retrobulbar optic neuritis (HP:0100654)4.47541419
12Optic neuritis (HP:0100653)4.47541419
13Complement deficiency (HP:0004431)4.43140778
14Intrahepatic cholestasis (HP:0001406)4.40802640
15Hypobetalipoproteinemia (HP:0003563)4.13273908
16Prolonged partial thromboplastin time (HP:0003645)4.00867761
17Hypercholesterolemia (HP:0003124)3.90895662
18Mediastinal lymphadenopathy (HP:0100721)3.90564273
19Hyperlipoproteinemia (HP:0010980)3.81305530
20Stomatitis (HP:0010280)3.73357499
21Increased IgE level (HP:0003212)3.67392554
22Hypoalphalipoproteinemia (HP:0003233)3.65304539
23Abnormality of complement system (HP:0005339)3.64753972
24Hypolipoproteinemia (HP:0010981)3.59760138
25Myocardial infarction (HP:0001658)3.55800329
26Abnormality of the common coagulation pathway (HP:0010990)3.51583488
27Elevated erythrocyte sedimentation rate (HP:0003565)3.49249316
28Abnormality of glycolipid metabolism (HP:0010969)3.45123211
29Abnormality of liposaccharide metabolism (HP:0010968)3.45123211
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.45123211
31Joint hemorrhage (HP:0005261)3.42866790
32Alopecia of scalp (HP:0002293)3.35270297
33Obstructive lung disease (HP:0006536)3.29913873
34Chronic obstructive pulmonary disease (HP:0006510)3.29913873
35Keratoconjunctivitis sicca (HP:0001097)3.29225060
36Meningitis (HP:0001287)3.21895283
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.21837776
38Gastrointestinal infarctions (HP:0005244)3.21789389
39Recurrent fungal infections (HP:0002841)3.19969992
40Recurrent skin infections (HP:0001581)3.14445991
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.11484121
42Vasculitis (HP:0002633)3.10130382
43Cellulitis (HP:0100658)3.05995139
44Recurrent gram-negative bacterial infections (HP:0005420)3.04675755
45Gingivitis (HP:0000230)2.99492835
46Epidermoid cyst (HP:0200040)2.97751718
47Keratoconjunctivitis (HP:0001096)2.94841513
48Hyperammonemia (HP:0001987)2.92671163
49Hypoglycemic coma (HP:0001325)2.91350029
50Urticaria (HP:0001025)2.90138499
51Ketosis (HP:0001946)2.83281000
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.83143931
53Polycythemia (HP:0001901)2.83000868
54Increased cerebral lipofuscin (HP:0011813)2.73118396
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.72779054
56Hyperacusis (HP:0010780)2.71012487
57Loss of speech (HP:0002371)2.69063695
58Dysostosis multiplex (HP:0000943)2.67770868
59Encephalitis (HP:0002383)2.66401582
60Pulmonary infiltrates (HP:0002113)2.66312689
61Recurrent viral infections (HP:0004429)2.65528775
62Systemic lupus erythematosus (HP:0002725)2.63913773
63Abnormality of the intrinsic pathway (HP:0010989)2.63127924
64Gingival bleeding (HP:0000225)2.61356948
65Abnormality of fatty-acid metabolism (HP:0004359)2.56568925
66Abnormality of pyrimidine metabolism (HP:0004353)2.56120891
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55466845
68Recurrent cutaneous fungal infections (HP:0011370)2.51924798
69Chronic mucocutaneous candidiasis (HP:0002728)2.51924798
70Hemoptysis (HP:0002105)2.51752419
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.43668800
72Arterial thrombosis (HP:0004420)2.43085497
73Chest pain (HP:0100749)2.41423870
74Hypertriglyceridemia (HP:0002155)2.39448114
75Esophageal varix (HP:0002040)2.37986321
76Inflammation of the large intestine (HP:0002037)2.37852002
77Gastrointestinal inflammation (HP:0004386)2.37715487
78Gastrointestinal stroma tumor (HP:0100723)2.30470692
79Abnormality of iron homeostasis (HP:0011031)2.30088363
80Spontaneous abortion (HP:0005268)2.28414496
81Vacuolated lymphocytes (HP:0001922)2.27674047
82Fat malabsorption (HP:0002630)2.26781395
83Increased IgM level (HP:0003496)2.26374364
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25125370
85Petechiae (HP:0000967)2.24695963
86Prolonged bleeding time (HP:0003010)2.24475026
87Abnormality of methionine metabolism (HP:0010901)2.24379133
88Menorrhagia (HP:0000132)2.23625026
89Abnormality of nucleobase metabolism (HP:0010932)2.23587678
90Slow saccadic eye movements (HP:0000514)2.23073500
91Episodic fever (HP:0001954)2.21681106
92Cholelithiasis (HP:0001081)2.21378405
93Reticulocytosis (HP:0001923)2.20607347
94Gangrene (HP:0100758)2.19161101
95Abnormality of the lower motor neuron (HP:0002366)2.18943505
96Osteomyelitis (HP:0002754)2.18239380
97Hyperglycinuria (HP:0003108)2.17305177
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.17232702
99Broad metatarsal (HP:0001783)2.16908285
100Anorexia (HP:0002039)2.16330845
101Mitral stenosis (HP:0001718)2.16231014
102Abnormality of transition element cation homeostasis (HP:0011030)2.13408118
103Abnormality of serine family amino acid metabolism (HP:0010894)2.12208739
104Abnormality of glycine metabolism (HP:0010895)2.12208739
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11847802
106Hypergammaglobulinemia (HP:0010702)2.11611140
107Peritonitis (HP:0002586)2.11530483
108Abnormal gallbladder physiology (HP:0012438)2.11262523
109Cholecystitis (HP:0001082)2.11262523
110Late onset (HP:0003584)2.10450816
111Ulnar bowing (HP:0003031)2.09508584
112T lymphocytopenia (HP:0005403)2.09446796
113Leukocytosis (HP:0001974)2.08814844
114Abnormal gallbladder morphology (HP:0012437)2.08542224
115Interstitial pulmonary disease (HP:0006530)2.08526752
116Abnormality of purine metabolism (HP:0004352)2.07321072
117Segmental peripheral demyelination/remyelination (HP:0003481)2.06634952
118Skin nodule (HP:0200036)2.04835668
119Glomerulopathy (HP:0100820)2.04771589
120Hyperglycinemia (HP:0002154)2.04429073
121Increased serum ferritin (HP:0003281)2.03766248
122Broad face (HP:0000283)2.02443588
123Abnormality of the pleura (HP:0002103)2.01238489
124Hypochromic microcytic anemia (HP:0004840)2.01222777
125Pulmonary embolism (HP:0002204)2.01096944
126Spontaneous hematomas (HP:0007420)2.00497438
127Purpura (HP:0000979)2.00081400
128Autoimmune thrombocytopenia (HP:0001973)1.99434073
129Abnormality of the peritoneum (HP:0002585)1.96567029
130Premature loss of primary teeth (HP:0006323)1.95985951
131Delayed CNS myelination (HP:0002188)1.95596950
132Abnormality of T cell number (HP:0011839)1.95451411
133Hemorrhage of the eye (HP:0011885)1.94673620
134Hypochromic anemia (HP:0001931)1.94665793
135Spastic diplegia (HP:0001264)1.94635881
136Disinhibition (HP:0000734)1.94549423
137Sepsis (HP:0100806)1.94410018
138Emphysema (HP:0002097)1.94393980
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94103994
140Abnormality of polysaccharide metabolism (HP:0011012)1.94103994
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94103994
142Lymphopenia (HP:0001888)1.93956082
143Cerebral palsy (HP:0100021)1.91767947
144Abnormality of the endocardium (HP:0004306)1.91666052
145Eczematoid dermatitis (HP:0000976)1.91313828
146Hyperbilirubinemia (HP:0002904)1.91154633
147Abnormality of the nasal mucosa (HP:0000433)1.89925857
148Granulocytopenia (HP:0001913)1.89817831
149Hepatosplenomegaly (HP:0001433)1.89810272
150Abnormality of the pericardium (HP:0001697)1.88833450
151Cheilitis (HP:0100825)1.88710749
152Hepatocellular carcinoma (HP:0001402)1.88562605
153Increased mean platelet volume (HP:0011877)1.88126328
154Epistaxis (HP:0000421)1.87810097
155Asymmetric septal hypertrophy (HP:0001670)1.87520070
156Restrictive lung disease (HP:0002091)1.87383987
157Skin ulcer (HP:0200042)1.86459148
158Increased connective tissue (HP:0009025)1.85726427
159Hyperglycemia (HP:0003074)1.85607992
160Nasal polyposis (HP:0100582)1.85415884
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.85078598
162Flat acetabular roof (HP:0003180)1.84742415
163Glomerulonephritis (HP:0000099)1.84191475
164Mucopolysacchariduria (HP:0008155)1.83804713
165Urinary glycosaminoglycan excretion (HP:0003541)1.83804713
166Ketoacidosis (HP:0001993)1.83132921
167Acne (HP:0001061)1.82290905
168Thrombophlebitis (HP:0004418)1.82264248
169Paralysis (HP:0003470)1.82032991
170Abnormal cartilage morphology (HP:0002763)1.81620181
171Abnormal platelet volume (HP:0011876)1.81132712
172Colitis (HP:0002583)1.78667555
173Malnutrition (HP:0004395)1.78450531
174Irritability (HP:0000737)1.77611660
175Turricephaly (HP:0000262)1.76502293
176Amyloidosis (HP:0011034)1.76007319
177Hand muscle atrophy (HP:0009130)1.75969397
178Upper limb amyotrophy (HP:0009129)1.75171752
179Distal upper limb amyotrophy (HP:0007149)1.75171752
180Abnormality of the Achilles tendon (HP:0005109)1.73097597
181Abnormal platelet function (HP:0011869)1.72626088
182Impaired platelet aggregation (HP:0003540)1.72626088
183Dicarboxylic aciduria (HP:0003215)1.72013178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.56655577
2TRIB34.06636079
3RIPK43.58792005
4PRPF4B3.36405418
5IRAK42.85300418
6MAP3K102.76002324
7CDK122.60420552
8IRAK32.60130717
9TAOK32.58676887
10BLK2.50993579
11PKN22.49359046
12CAMK1D2.49074427
13SIK12.48932556
14EEF2K2.34200832
15MAP3K142.31057535
16TAOK12.21381655
17MAP4K12.17453020
18STK102.11927467
19FGFR41.97108396
20TAOK21.94803556
21BCKDK1.94306539
22SMG11.72300572
23MAP3K131.66205283
24GRK61.65900911
25RIPK11.63356261
26LATS11.60434607
27KDR1.59299368
28CAMK1G1.55566164
29FGR1.43978227
30TNK21.40080159
31ICK1.39484747
32CSK1.38486434
33TYK21.37723381
34TTN1.36885903
35FES1.36590895
36SIK21.35879036
37PTK61.35083766
38JAK31.31642459
39SIK31.29607983
40LRRK21.28698860
41MAP3K61.28595104
42IRAK21.28382620
43PIM11.23894855
44ERBB41.22536455
45TBK11.22266849
46FLT31.19257670
47BMX1.15396150
48KIT1.14806810
49EPHB11.14511919
50IRAK11.08485247
51TGFBR21.08465786
52SYK1.07306140
53PTK21.06411106
54MAPK111.06355165
55NME21.05081728
56CDC42BPA1.04228650
57TESK21.02928802
58LATS21.00655242
59GRK71.00239743
60ZAP701.00122431
61TXK0.98357532
62MAP2K30.95340832
63LYN0.91653752
64JAK20.89659326
65* MTOR0.87857503
66NEK20.87347305
67MAP3K110.86713055
68DYRK1B0.85180824
69PIK3CG0.83746696
70TYRO30.81367669
71CSF1R0.80461281
72TTK0.78954527
73LCK0.78490912
74CHUK0.78429535
75CDK40.77969357
76ITK0.76834488
77JAK10.76547494
78PDPK10.75517787
79STK30.74926963
80BMPR20.74692228
81MAPK70.74487871
82MARK30.72562265
83PDK10.72506958
84PRKD20.68573650
85MAPK120.66717102
86CDK90.66139823
87PRKG20.64889726
88CAMK40.64257781
89HIPK20.64065538
90PIK3CA0.63589068
91PDGFRA0.60677543
92RPS6KA40.60578001
93MAP3K50.59214105
94MAP3K80.58576575
95RPS6KC10.58532580
96RPS6KL10.58532580
97ALK0.58515121
98RAF10.58283330
99MAPKAPK30.58102240
100MAP3K30.57664856
101BTK0.57620342
102ARAF0.56822066
103CDK60.56152106
104MAP3K70.55254956
105EPHA20.54207564
106KSR20.53319848
107ABL20.52546414
108RPS6KB20.51237653
109PIM20.51220736
110PRKAA20.51015697
111MATK0.50575167
112RPS6KA10.49903953
113PRKAA10.49674906
114CDK70.49156576
115HCK0.48457701
116SGK30.48375832
117DDR20.47660250
118FGFR30.46573950
119YES10.45339158
120RPS6KA60.43029298
121MAPKAPK20.42673100
122MOS0.42583582
123MST1R0.41203744
124IKBKB0.41178971
125MAP3K20.41175346
126MAPK40.41157468
127PAK40.39016474
128MAP2K20.38827063
129EPHA30.38579005
130MARK20.38470354
131MAP3K10.38406474
132RPS6KA20.38091793
133KSR10.37857093
134MAP3K90.37088974
135AURKB0.37071009
136CHEK20.36494168
137IKBKE0.35949277
138BRAF0.34239938
139MAPK10.34065396
140EGFR0.34051253
141NEK10.33001472
142DAPK20.32433002
143TESK10.31802896

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.73768558
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99728565
3Complement and coagulation cascades_Homo sapiens_hsa046102.99316463
4Arginine biosynthesis_Homo sapiens_hsa002202.89172646
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.87701092
6Nitrogen metabolism_Homo sapiens_hsa009102.60934603
7Tryptophan metabolism_Homo sapiens_hsa003802.60602720
8Staphylococcus aureus infection_Homo sapiens_hsa051502.53026280
9Caffeine metabolism_Homo sapiens_hsa002322.46779558
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35017012
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23698867
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21005850
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.10261556
14Fatty acid degradation_Homo sapiens_hsa000712.08604487
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07945717
16PPAR signaling pathway_Homo sapiens_hsa033202.04280920
17Allograft rejection_Homo sapiens_hsa053302.04275758
18Malaria_Homo sapiens_hsa051441.98265636
19Graft-versus-host disease_Homo sapiens_hsa053321.98037062
20Tuberculosis_Homo sapiens_hsa051521.97894196
21Histidine metabolism_Homo sapiens_hsa003401.90348391
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88739429
23Butanoate metabolism_Homo sapiens_hsa006501.87050995
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84451646
25TNF signaling pathway_Homo sapiens_hsa046681.84192501
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78486183
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75925050
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73911411
29Selenocompound metabolism_Homo sapiens_hsa004501.73309763
30Autoimmune thyroid disease_Homo sapiens_hsa053201.73255406
31Influenza A_Homo sapiens_hsa051641.71972817
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.66096379
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62959124
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62123505
35Measles_Homo sapiens_hsa051621.59849455
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59006566
37Folate biosynthesis_Homo sapiens_hsa007901.55777713
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55216379
39Lysine degradation_Homo sapiens_hsa003101.53111152
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52082171
41Peroxisome_Homo sapiens_hsa041461.51913497
42Biosynthesis of amino acids_Homo sapiens_hsa012301.51906938
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.50193731
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48849456
45Viral myocarditis_Homo sapiens_hsa054161.43768464
46Herpes simplex infection_Homo sapiens_hsa051681.42921266
47Pertussis_Homo sapiens_hsa051331.40884348
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40531564
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40362078
50African trypanosomiasis_Homo sapiens_hsa051431.36735889
51Chemokine signaling pathway_Homo sapiens_hsa040621.36582723
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36323196
53T cell receptor signaling pathway_Homo sapiens_hsa046601.36218750
54Hepatitis B_Homo sapiens_hsa051611.35871674
55Fatty acid metabolism_Homo sapiens_hsa012121.35741926
56Antigen processing and presentation_Homo sapiens_hsa046121.35343275
57Propanoate metabolism_Homo sapiens_hsa006401.35217057
58Phenylalanine metabolism_Homo sapiens_hsa003601.32974134
59Chemical carcinogenesis_Homo sapiens_hsa052041.32615677
60Hematopoietic cell lineage_Homo sapiens_hsa046401.31712407
61Rheumatoid arthritis_Homo sapiens_hsa053231.31211933
62Hepatitis C_Homo sapiens_hsa051601.31202734
63beta-Alanine metabolism_Homo sapiens_hsa004101.28175511
64Type I diabetes mellitus_Homo sapiens_hsa049401.26017916
65Fat digestion and absorption_Homo sapiens_hsa049751.25846640
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25194934
67Asthma_Homo sapiens_hsa053101.24901416
68ABC transporters_Homo sapiens_hsa020101.24860326
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24762217
70Salmonella infection_Homo sapiens_hsa051321.24101374
71Bile secretion_Homo sapiens_hsa049761.23596256
72Carbon metabolism_Homo sapiens_hsa012001.22445692
73Lysosome_Homo sapiens_hsa041421.21900202
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18243991
75Pyruvate metabolism_Homo sapiens_hsa006201.17943397
76VEGF signaling pathway_Homo sapiens_hsa043701.13121700
77Phagosome_Homo sapiens_hsa041451.12291609
78Non-small cell lung cancer_Homo sapiens_hsa052231.09306055
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09175351
80Pentose phosphate pathway_Homo sapiens_hsa000301.07338493
81Sulfur metabolism_Homo sapiens_hsa009201.06066814
82Steroid hormone biosynthesis_Homo sapiens_hsa001401.05211117
83Cysteine and methionine metabolism_Homo sapiens_hsa002701.05033884
84Starch and sucrose metabolism_Homo sapiens_hsa005001.04540155
85Leukocyte transendothelial migration_Homo sapiens_hsa046701.03090047
86Cyanoamino acid metabolism_Homo sapiens_hsa004601.02709250
87Retinol metabolism_Homo sapiens_hsa008301.00774451
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.97192337
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96311974
90Tyrosine metabolism_Homo sapiens_hsa003500.95667401
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.95013052
92Prolactin signaling pathway_Homo sapiens_hsa049170.93894274
93Vitamin B6 metabolism_Homo sapiens_hsa007500.93280291
94Arginine and proline metabolism_Homo sapiens_hsa003300.92892699
95One carbon pool by folate_Homo sapiens_hsa006700.91718848
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91058035
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90007164
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.89568293
99Renal cell carcinoma_Homo sapiens_hsa052110.89389063
100Sulfur relay system_Homo sapiens_hsa041220.86513807
101Insulin resistance_Homo sapiens_hsa049310.84151010
102Epstein-Barr virus infection_Homo sapiens_hsa051690.82917881
103Viral carcinogenesis_Homo sapiens_hsa052030.80943926
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79869363
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.77558907
106Vitamin digestion and absorption_Homo sapiens_hsa049770.75842749
107Glycerolipid metabolism_Homo sapiens_hsa005610.74714469
108HTLV-I infection_Homo sapiens_hsa051660.73927806
109Platelet activation_Homo sapiens_hsa046110.70970173
110Endocytosis_Homo sapiens_hsa041440.69303199
111Fructose and mannose metabolism_Homo sapiens_hsa000510.68754029
112Endometrial cancer_Homo sapiens_hsa052130.66485362
113HIF-1 signaling pathway_Homo sapiens_hsa040660.66384059
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65707974
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.62930122
116GnRH signaling pathway_Homo sapiens_hsa049120.62928146
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58222501
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54870611
119Prostate cancer_Homo sapiens_hsa052150.54206555
120ErbB signaling pathway_Homo sapiens_hsa040120.53999135
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53212802
122MAPK signaling pathway_Homo sapiens_hsa040100.52641562
123Dorso-ventral axis formation_Homo sapiens_hsa043200.51520895
124Bladder cancer_Homo sapiens_hsa052190.51001628
125Galactose metabolism_Homo sapiens_hsa000520.49212969
126Acute myeloid leukemia_Homo sapiens_hsa052210.48916839
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.48890047
128Notch signaling pathway_Homo sapiens_hsa043300.48883840
129Type II diabetes mellitus_Homo sapiens_hsa049300.48573723
130Colorectal cancer_Homo sapiens_hsa052100.47675440
131Choline metabolism in cancer_Homo sapiens_hsa052310.47356801
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46509802
133Fatty acid biosynthesis_Homo sapiens_hsa000610.45234651
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45213504
135AMPK signaling pathway_Homo sapiens_hsa041520.43752215
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41633455
137Glioma_Homo sapiens_hsa052140.41522505
138Proteoglycans in cancer_Homo sapiens_hsa052050.40500724
139Leishmaniasis_Homo sapiens_hsa051400.39797921
140Inositol phosphate metabolism_Homo sapiens_hsa005620.38961621
141Osteoclast differentiation_Homo sapiens_hsa043800.38009906
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37867625
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36660115
144Prion diseases_Homo sapiens_hsa050200.36622838
145Chronic myeloid leukemia_Homo sapiens_hsa052200.36489270
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36265084
147Estrogen signaling pathway_Homo sapiens_hsa049150.35357061
148Glucagon signaling pathway_Homo sapiens_hsa049220.33785812
149Glutathione metabolism_Homo sapiens_hsa004800.32072708
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.31407820
151Apoptosis_Homo sapiens_hsa042100.30087752
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29913365
153B cell receptor signaling pathway_Homo sapiens_hsa046620.29528676
154Insulin signaling pathway_Homo sapiens_hsa049100.29182298
155Linoleic acid metabolism_Homo sapiens_hsa005910.28504344
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27995069
157Legionellosis_Homo sapiens_hsa051340.27895753
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.25022402
159Shigellosis_Homo sapiens_hsa051310.23775596
160Circadian rhythm_Homo sapiens_hsa047100.23522929
161mTOR signaling pathway_Homo sapiens_hsa041500.22985409
162Toxoplasmosis_Homo sapiens_hsa051450.22628648
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.22616406
164Small cell lung cancer_Homo sapiens_hsa052220.22060258
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22048330
166Amoebiasis_Homo sapiens_hsa051460.20883222
167Primary immunodeficiency_Homo sapiens_hsa053400.19118673
168FoxO signaling pathway_Homo sapiens_hsa040680.18689352
169Other glycan degradation_Homo sapiens_hsa005110.18206384
170Pancreatic cancer_Homo sapiens_hsa052120.17893708
171Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17300375

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