ELL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of extracellular matrix disassembly (GO:0010715)4.37185846
2regulation of type B pancreatic cell apoptotic process (GO:2000674)4.19446437
3positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.13586855
4COPII vesicle coating (GO:0048208)3.89548948
5regulation of transforming growth factor beta1 production (GO:0032908)3.87217914
6positive regulation by symbiont of host defense response (GO:0052509)3.86788018
7modulation by symbiont of host defense response (GO:0052031)3.86788018
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86788018
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86788018
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.86788018
11modulation by symbiont of host immune response (GO:0052553)3.86788018
12cysteine metabolic process (GO:0006534)3.85273205
13L-phenylalanine catabolic process (GO:0006559)3.80058717
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.80058717
15plasma lipoprotein particle clearance (GO:0034381)3.65118353
16negative regulation of complement activation (GO:0045916)3.65011005
17low-density lipoprotein particle clearance (GO:0034383)3.62262264
18peptide hormone processing (GO:0016486)3.61404438
19cell adhesion mediated by integrin (GO:0033627)3.60864902
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58928285
21L-phenylalanine metabolic process (GO:0006558)3.58928285
22negative regulation of protein activation cascade (GO:2000258)3.51739457
23aromatic amino acid family catabolic process (GO:0009074)3.50903254
24macroautophagy (GO:0016236)3.50842009
25positive regulation of heat generation (GO:0031652)3.49849651
26protein carboxylation (GO:0018214)3.47379959
27peptidyl-glutamic acid carboxylation (GO:0017187)3.47379959
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.45321595
29intestinal cholesterol absorption (GO:0030299)3.44664122
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42567597
31regulation of fever generation (GO:0031620)3.41995314
32negative regulation of lipid storage (GO:0010888)3.39519990
33positive regulation of interferon-alpha production (GO:0032727)3.37427012
34negative regulation of execution phase of apoptosis (GO:1900118)3.36475463
35iron ion import (GO:0097286)3.34095079
36regulation of interferon-alpha production (GO:0032647)3.32194372
37regulation of cholesterol storage (GO:0010885)3.28199168
38indolalkylamine catabolic process (GO:0046218)3.20903006
39tryptophan catabolic process (GO:0006569)3.20903006
40indole-containing compound catabolic process (GO:0042436)3.20903006
41tryptophan metabolic process (GO:0006568)3.16387006
42response to peptidoglycan (GO:0032494)3.12443528
43homocysteine metabolic process (GO:0050667)3.12362405
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.11356398
45urea cycle (GO:0000050)3.11006815
46urea metabolic process (GO:0019627)3.11006815
47very-low-density lipoprotein particle assembly (GO:0034379)3.10213599
48positive regulation of calcium ion import (GO:0090280)3.09958554
49glycerophospholipid catabolic process (GO:0046475)3.06280728
50complement activation, alternative pathway (GO:0006957)3.05406585
51nodal signaling pathway (GO:0038092)3.05403566
52regulation of interferon-beta biosynthetic process (GO:0045357)3.04211444
53neutrophil activation involved in immune response (GO:0002283)3.03441986
54sulfur amino acid catabolic process (GO:0000098)3.01045974
55sequestering of extracellular ligand from receptor (GO:0035581)2.98444704
56regulation of metalloenzyme activity (GO:0048552)2.94638078
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.94432160
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92810594
59kynurenine metabolic process (GO:0070189)2.92631506
60positive regulation of interferon-beta production (GO:0032728)2.92429505
61plasma lipoprotein particle assembly (GO:0034377)2.90969228
62regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90711193
63skin morphogenesis (GO:0043589)2.90207027
64positive regulation of chemokine biosynthetic process (GO:0045080)2.88093773
65insulin secretion (GO:0030073)2.87927494
66acute-phase response (GO:0006953)2.86496288
67hydrogen peroxide biosynthetic process (GO:0050665)2.86319444
68UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85457681
69regulation of execution phase of apoptosis (GO:1900117)2.85356822
70bile acid biosynthetic process (GO:0006699)2.84864248
71nitrogen cycle metabolic process (GO:0071941)2.84104862
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.83737954
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83152599
74alpha-linolenic acid metabolic process (GO:0036109)2.82205296
75positive regulation of macroautophagy (GO:0016239)2.81528383
76L-alpha-amino acid transmembrane transport (GO:1902475)2.80432026
77negative regulation of fibrinolysis (GO:0051918)2.80339660
78serine family amino acid catabolic process (GO:0009071)2.78779046
79regulation of heterotypic cell-cell adhesion (GO:0034114)2.78747523
80regulation of triglyceride catabolic process (GO:0010896)2.77186303
81cholesterol efflux (GO:0033344)2.76690697
82regulation of protein activation cascade (GO:2000257)2.76207264
83protein-lipid complex assembly (GO:0065005)2.75681186
84triglyceride homeostasis (GO:0070328)2.74709602
85acylglycerol homeostasis (GO:0055090)2.74709602
86positive regulation of lipid storage (GO:0010884)2.74661216
87epithelial cell fate commitment (GO:0072148)2.74572001
88lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74334552
89positive regulation of lipid catabolic process (GO:0050996)2.73760346
90ovulation from ovarian follicle (GO:0001542)2.73468244
91natural killer cell mediated immunity (GO:0002228)2.73300568
92natural killer cell mediated cytotoxicity (GO:0042267)2.73300568
93high-density lipoprotein particle remodeling (GO:0034375)2.73253497
94oligosaccharide catabolic process (GO:0009313)2.72441880
95desmosome organization (GO:0002934)2.72363021
96bile acid metabolic process (GO:0008206)2.72222714
97regulation of heat generation (GO:0031650)2.72195310
98phospholipid efflux (GO:0033700)2.71973726
99positive regulation of triglyceride lipase activity (GO:0061365)2.71758404
100positive regulation of lipoprotein lipase activity (GO:0051006)2.71758404
101cellular zinc ion homeostasis (GO:0006882)2.71035674
102nitric oxide biosynthetic process (GO:0006809)2.69590882
103cofactor catabolic process (GO:0051187)2.67812724
104positive regulation of protein autophosphorylation (GO:0031954)2.67167049
105keratan sulfate catabolic process (GO:0042340)2.67050382
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65088345
107regulation of cytokine secretion involved in immune response (GO:0002739)2.64917213
108positive regulation of transforming growth factor beta production (GO:0071636)2.64369437
109macrophage activation involved in immune response (GO:0002281)2.64081103
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.62284062
111regulation of fibrinolysis (GO:0051917)2.61262773
112retinol metabolic process (GO:0042572)2.60907057
113positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.60616738
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.60397095
115reverse cholesterol transport (GO:0043691)2.59178460
116regulation of complement activation (GO:0030449)2.58835005
117regulation of cholesterol homeostasis (GO:2000188)2.58221642
118protoporphyrinogen IX metabolic process (GO:0046501)2.58007537
119detection of molecule of bacterial origin (GO:0032490)2.56843835
120signal peptide processing (GO:0006465)2.56825932
121positive regulation of p38MAPK cascade (GO:1900745)2.56740494
122positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55323876
123negative regulation of humoral immune response (GO:0002921)2.54712640
124positive regulation of gluconeogenesis (GO:0045722)2.54676841
125cellular response to zinc ion (GO:0071294)2.53350643
126hemidesmosome assembly (GO:0031581)2.52809911
127regulation of plasminogen activation (GO:0010755)2.52484387
128negative regulation of fatty acid biosynthetic process (GO:0045717)2.50887814
129sphingomyelin metabolic process (GO:0006684)2.50815307
130bile acid and bile salt transport (GO:0015721)2.50748100
131phospholipid homeostasis (GO:0055091)2.50426260
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49718074
133response to host immune response (GO:0052572)2.49718074
134valine metabolic process (GO:0006573)2.48743293
135positive regulation of cellular amide metabolic process (GO:0034250)2.46585013
136aromatic amino acid family metabolic process (GO:0009072)2.46555947
137regulation of energy homeostasis (GO:2000505)2.46507919
138plasma lipoprotein particle remodeling (GO:0034369)2.45656600
139protein-lipid complex remodeling (GO:0034368)2.45656600
140macromolecular complex remodeling (GO:0034367)2.45656600
141cellular response to virus (GO:0098586)2.45500868
142smooth muscle tissue development (GO:0048745)2.45223256
143regulation of collagen metabolic process (GO:0010712)2.45158418
144regulation of mononuclear cell migration (GO:0071675)2.44409424
145glyoxylate metabolic process (GO:0046487)2.43922716
146regulation of integrin-mediated signaling pathway (GO:2001044)2.43416848
147endocrine pancreas development (GO:0031018)2.41986126
148zinc ion transmembrane transport (GO:0071577)2.41382014
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38213582
150regulation of calcium ion import (GO:0090279)2.37748060
151positive regulation of response to nutrient levels (GO:0032109)2.36732988
152positive regulation of response to extracellular stimulus (GO:0032106)2.36732988
153regulation of extracellular matrix organization (GO:1903053)2.34591235
154negative regulation of activin receptor signaling pathway (GO:0032926)2.33060421
155membrane lipid catabolic process (GO:0046466)2.32509353
156cellular response to ethanol (GO:0071361)2.30930957
157regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.29596684
158sphingolipid catabolic process (GO:0030149)2.29265497
159extracellular negative regulation of signal transduction (GO:1900116)2.28543907
160extracellular regulation of signal transduction (GO:1900115)2.28543907
161negative regulation of endothelial cell apoptotic process (GO:2000352)2.28319455
162eosinophil chemotaxis (GO:0048245)2.27616047
163endosome to pigment granule transport (GO:0043485)2.27437434
164endosome to melanosome transport (GO:0035646)2.27437434
165auditory receptor cell differentiation (GO:0042491)2.27026364
166zinc ion homeostasis (GO:0055069)2.26771969
167inositol phosphate-mediated signaling (GO:0048016)2.26439482
168import into cell (GO:0098657)2.25931008
169magnesium ion transport (GO:0015693)2.24533266
170phosphorylated carbohydrate dephosphorylation (GO:0046838)2.24275375
171inositol phosphate dephosphorylation (GO:0046855)2.24275375
172dicarboxylic acid biosynthetic process (GO:0043650)2.23427903
173negative regulation of hormone biosynthetic process (GO:0032353)2.21842863
174sequestering of metal ion (GO:0051238)2.20436696
175detection of calcium ion (GO:0005513)2.19309964
176transcytosis (GO:0045056)2.19291110
177platelet-derived growth factor receptor signaling pathway (GO:0048008)2.17674967
178positive regulation of insulin secretion (GO:0032024)2.17312502
179decidualization (GO:0046697)2.16715430
180ER overload response (GO:0006983)2.16568334
181vasodilation (GO:0042311)2.15759515
182interleukin-6-mediated signaling pathway (GO:0070102)2.15712057
183cellular ketone body metabolic process (GO:0046950)2.15047700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.81839068
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.58192552
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.52581049
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.01414165
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.91221270
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.90041887
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.81996733
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.26476610
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16792733
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13433917
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.95442730
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.86027301
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80416809
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76341917
15GATA1_22025678_ChIP-Seq_K562_Human2.72972434
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70295392
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.67921496
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61905240
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50487241
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.40659703
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33923226
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.24715476
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24533571
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14022262
25* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13558721
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11688144
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08010710
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07193627
29CJUN_26792858_Chip-Seq_BT549_Human1.99069839
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.90674405
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82791377
32* BRD4_25478319_ChIP-Seq_HGPS_Human1.82286128
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81445591
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75310642
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71155908
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66069969
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63912219
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63581761
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61490982
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61015597
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60859058
42* PIAS1_25552417_ChIP-Seq_VCAP_Human1.60838802
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.58518641
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.52378053
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50484963
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49890181
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48823903
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48448695
49TP53_18474530_ChIP-ChIP_U2OS_Human1.45260152
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.42902365
51* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41761488
52* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41761488
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41279919
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38660912
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37447539
56GBX2_23144817_ChIP-Seq_PC3_Human1.35457719
57* TP63_23658742_ChIP-Seq_EP156T_Human1.33961168
58* WT1_19549856_ChIP-ChIP_CCG9911_Human1.33691754
59GATA1_19941826_ChIP-Seq_K562_Human1.33412201
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33323871
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33217323
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31862380
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31811581
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31267620
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.27504502
66GATA4_25053715_ChIP-Seq_YYC3_Human1.26525624
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26352436
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26275675
69PU_27001747_Chip-Seq_BMDM_Mouse1.26039070
70* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25959733
71JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25629786
72* CDX2_22108803_ChIP-Seq_LS180_Human1.24347752
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.23865042
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22424526
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21953138
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.20203860
77* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18143467
78CLOCK_20551151_ChIP-Seq_293T_Human1.17944165
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17403099
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16870888
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.16772987
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16692247
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.16040356
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14340983
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12174561
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11619597
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.11264010
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10974803
89AHR_22903824_ChIP-Seq_MCF-7_Human1.09366204
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08953503
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.08682890
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08470776
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08123067
94* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08019212
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.07926549
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07520165
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07190862
98GATA6_25053715_ChIP-Seq_YYC3_Human1.07136033
99TP53_16413492_ChIP-PET_HCT116_Human1.06687330
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06539404
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.06330128
102* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06162099
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06038920
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.05511162
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.05385544
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.05006205
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04795784
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04328470
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.03974938
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.03952654
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03892922
112GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03560395
113PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03507549
114VDR_24787735_ChIP-Seq_THP-1_Human1.02910457
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02799078
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02307239
117* GATA2_19941826_ChIP-Seq_K562_Human1.01977589
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01886605
119* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01784145
120P53_22387025_ChIP-Seq_ESCs_Mouse1.01668971
121MYB_26560356_Chip-Seq_TH1_Human1.00836720
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.99187493
123NMYC_18555785_Chip-Seq_ESCs_Mouse0.98794661
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97223064
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97223064
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96202872
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96103034
128MYB_26560356_Chip-Seq_TH2_Human0.95835374
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95643934
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95559730
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92787934
132SCL_19346495_ChIP-Seq_HPC-7_Human0.92451507
133SPI1_23547873_ChIP-Seq_NB4_Human0.91949500
134TFEB_21752829_ChIP-Seq_HELA_Human0.91711877
135RUNX_20019798_ChIP-Seq_JUKART_Human0.91095491
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91069599
137* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89474666
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89322529
139* SOX2_20726797_ChIP-Seq_SW620_Human0.88593898
140* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86603660
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86295153
142* HNF4A_19822575_ChIP-Seq_HepG2_Human0.86020113
143FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85418339
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84595352
145GATA3_26560356_Chip-Seq_TH2_Human0.84215500
146* RUNX1_22412390_ChIP-Seq_EML_Mouse0.84077836
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83480329
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82643992
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.82588719
150* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81047900
151E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78449625
152GATA3_27048872_Chip-Seq_THYMUS_Human0.77893989
153BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77136751
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77067540
155SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76899089
156MAF_26560356_Chip-Seq_TH1_Human0.76498515
157PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75809762
158* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75701194
159AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74706481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.54675410
2MP0002139_abnormal_hepatobiliary_system4.43100888
3MP0010234_abnormal_vibrissa_follicle3.63443367
4MP0005360_urolithiasis3.55465921
5MP0005365_abnormal_bile_salt3.53526531
6MP0000013_abnormal_adipose_tissue3.35648900
7MP0005085_abnormal_gallbladder_physiolo3.34413831
8MP0008438_abnormal_cutaneous_collagen3.30437509
9MP0002837_dystrophic_cardiac_calcinosis3.30025177
10MP0006054_spinal_hemorrhage3.06272790
11MP0005379_endocrine/exocrine_gland_phen3.05097944
12MP0003950_abnormal_plasma_membrane2.97723514
13MP0009840_abnormal_foam_cell2.72743957
14MP0003195_calcinosis2.64679246
15MP0003656_abnormal_erythrocyte_physiolo2.63760454
16MP0005083_abnormal_biliary_tract2.49171288
17MP0003436_decreased_susceptibility_to2.40486699
18MP0002909_abnormal_adrenal_gland2.32958804
19MP0003303_peritoneal_inflammation2.25378834
20MP0003806_abnormal_nucleotide_metabolis2.22229311
21MP0006082_CNS_inflammation2.20868229
22MP0008875_abnormal_xenobiotic_pharmacok2.20676066
23MP0003252_abnormal_bile_duct2.15529948
24MP0001666_abnormal_nutrient_absorption2.13940559
25MP0001835_abnormal_antigen_presentation2.12162386
26MP0000003_abnormal_adipose_tissue2.07467821
27MP0005058_abnormal_lysosome_morphology2.06247186
28MP0003191_abnormal_cellular_cholesterol2.05140271
29MP0009785_altered_susceptibility_to1.99731764
30MP0002138_abnormal_hepatobiliary_system1.93579676
31MP0002163_abnormal_gland_morphology1.91769404
32MP0005275_abnormal_skin_tensile1.90915801
33MP0010329_abnormal_lipoprotein_level1.85637867
34MP0002876_abnormal_thyroid_physiology1.81100802
35MP0001944_abnormal_pancreas_morphology1.79947844
36MP0002419_abnormal_innate_immunity1.79908434
37MP0003724_increased_susceptibility_to1.78551434
38MP0000609_abnormal_liver_physiology1.76071400
39MP0010386_abnormal_urinary_bladder1.76028727
40MP0001790_abnormal_immune_system1.73876269
41MP0005387_immune_system_phenotype1.73876269
42MP0009764_decreased_sensitivity_to1.71911358
43MP0005000_abnormal_immune_tolerance1.71265155
44MP0002295_abnormal_pulmonary_circulatio1.69499397
45MP0004947_skin_inflammation1.63820939
46MP0000685_abnormal_immune_system1.58089400
47MP0003300_gastrointestinal_ulcer1.57842245
48MP0005025_abnormal_response_to1.57523153
49MP0004272_abnormal_basement_membrane1.56254700
50MP0002148_abnormal_hypersensitivity_rea1.55539234
51MP0002060_abnormal_skin_morphology1.55524424
52MP0002254_reproductive_system_inflammat1.54403886
53MP0003186_abnormal_redox_activity1.52057485
54MP0008469_abnormal_protein_level1.51586996
55MP0001533_abnormal_skeleton_physiology1.44607245
56MP0005332_abnormal_amino_acid1.42459129
57MP0005319_abnormal_enzyme/_coenzyme1.41667516
58MP0002118_abnormal_lipid_homeostasis1.41317981
59MP0010678_abnormal_skin_adnexa1.40756666
60MP0001800_abnormal_humoral_immune1.40720104
61MP0002452_abnormal_antigen_presenting1.36805064
62MP0001845_abnormal_inflammatory_respons1.35765832
63MP0002723_abnormal_immune_serum1.35216127
64MP0004019_abnormal_vitamin_homeostasis1.34986976
65MP0001756_abnormal_urination1.33718725
66MP0005464_abnormal_platelet_physiology1.32564066
67MP0003868_abnormal_feces_composition1.30750060
68MP0001501_abnormal_sleep_pattern1.27092577
69MP0001545_abnormal_hematopoietic_system1.26733349
70MP0005397_hematopoietic_system_phenotyp1.26733349
71MP0005310_abnormal_salivary_gland1.25826716
72MP0001881_abnormal_mammary_gland1.24174814
73MP0003705_abnormal_hypodermis_morpholog1.21840272
74MP0003453_abnormal_keratinocyte_physiol1.20863783
75MP0003448_altered_tumor_morphology1.19648019
76MP0003045_fibrosis1.18117383
77MP0003091_abnormal_cell_migration1.17860221
78MP0003279_aneurysm1.14843169
79MP0003941_abnormal_skin_development1.14037113
80MP0005451_abnormal_body_composition1.13877808
81MP0009278_abnormal_bone_marrow1.13844198
82MP0009763_increased_sensitivity_to1.13705816
83MP0000604_amyloidosis1.12877247
84MP0003172_abnormal_lysosome_physiology1.12700797
85MP0002877_abnormal_melanocyte_morpholog1.12195750
86MP0010307_abnormal_tumor_latency1.11935580
87MP0005671_abnormal_response_to1.10278898
88MP0010368_abnormal_lymphatic_system1.09597736
89MP0002896_abnormal_bone_mineralization1.06733108
90MP0005076_abnormal_cell_differentiation1.06604376
91MP0003075_altered_response_to1.06329282
92MP0005375_adipose_tissue_phenotype1.06214241
93MP0001958_emphysema1.05867033
94MP0000598_abnormal_liver_morphology1.05669532
95MP0004510_myositis1.05157371
96MP0010352_gastrointestinal_tract_polyps1.03671750
97MP0005645_abnormal_hypothalamus_physiol1.03232626
98MP0002078_abnormal_glucose_homeostasis1.02961563
99MP0009643_abnormal_urine_homeostasis1.02474308
100MP0010155_abnormal_intestine_physiology1.02050700
101MP0001819_abnormal_immune_cell1.01629977
102MP0002405_respiratory_system_inflammati1.00608761
103MP0002420_abnormal_adaptive_immunity0.99730438
104MP0002168_other_aberrant_phenotype0.98030479
105MP0003690_abnormal_glial_cell0.96958908
106MP0002998_abnormal_bone_remodeling0.96192234
107MP0001243_abnormal_dermal_layer0.94664001
108MP0001764_abnormal_homeostasis0.93635679
109MP0009333_abnormal_splenocyte_physiolog0.93623182
110MP0008004_abnormal_stomach_pH0.93303243
111MP0002006_tumorigenesis0.92729273
112MP0002277_abnormal_respiratory_mucosa0.92284770
113MP0005084_abnormal_gallbladder_morpholo0.91922707
114MP0004147_increased_porphyrin_level0.91920168
115MP0001661_extended_life_span0.90776499
116MP0005448_abnormal_energy_balance0.90570583
117MP0000858_altered_metastatic_potential0.90565028
118MP0004264_abnormal_extraembryonic_tissu0.88403891
119MP0005165_increased_susceptibility_to0.88288582
120MP0005164_abnormal_response_to0.87266283
121MP0005584_abnormal_enzyme/coenzyme_acti0.86931871
122MP0001853_heart_inflammation0.86049060
123MP0000639_abnormal_adrenal_gland0.85208691
124MP0002166_altered_tumor_susceptibility0.84522133
125MP0001216_abnormal_epidermal_layer0.83715712
126MP0003633_abnormal_nervous_system0.82789902
127MP0009765_abnormal_xenobiotic_induced0.82010471
128MP0002693_abnormal_pancreas_physiology0.81945192
129MP0006072_abnormal_retinal_apoptosis0.81889592
130MP0004185_abnormal_adipocyte_glucose0.81601937
131MP0005220_abnormal_exocrine_pancreas0.81086531
132MP0005166_decreased_susceptibility_to0.80642135
133MP0000343_altered_response_to0.80470426
134MP0004782_abnormal_surfactant_physiolog0.79853927
135MP0003566_abnormal_cell_adhesion0.79295170
136MP0009384_cardiac_valve_regurgitation0.77803067
137MP0005636_abnormal_mineral_homeostasis0.77616453
138MP0000716_abnormal_immune_system0.75198718
139MP0000427_abnormal_hair_cycle0.73576044
140MP0001765_abnormal_ion_homeostasis0.73108201
141MP0002136_abnormal_kidney_physiology0.72473231
142MP0005023_abnormal_wound_healing0.72178592
143MP0005257_abnormal_intraocular_pressure0.72106102
144MP0000767_abnormal_smooth_muscle0.72005597
145MP0000689_abnormal_spleen_morphology0.71723751
146MP0001542_abnormal_bone_strength0.70899314
147MP0003011_delayed_dark_adaptation0.70647898
148MP0000627_abnormal_mammary_gland0.70541431
149MP0000538_abnormal_urinary_bladder0.69988731
150MP0002971_abnormal_brown_adipose0.68816854
151MP0005409_darkened_coat_color0.68669308
152MP0003795_abnormal_bone_structure0.67960251
153MP0005595_abnormal_vascular_smooth0.67763371
154MP0002933_joint_inflammation0.66622221
155MP0005535_abnormal_body_temperature0.65600205
156MP0005167_abnormal_blood-brain_barrier0.64196288
157MP0003953_abnormal_hormone_level0.64099154

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)4.42258181
2Intrahepatic cholestasis (HP:0001406)4.29442441
3Myocardial infarction (HP:0001658)4.22282010
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.07943198
5Xanthomatosis (HP:0000991)3.95908367
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81599225
7Deep venous thrombosis (HP:0002625)3.76842184
8Abnormality of glycolipid metabolism (HP:0010969)3.75436696
9Abnormality of liposaccharide metabolism (HP:0010968)3.75436696
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.75436696
11Eczematoid dermatitis (HP:0000976)3.67069945
12Recurrent bacterial skin infections (HP:0005406)3.58991606
13Increased CSF protein (HP:0002922)3.58562043
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.56882542
15Mitral stenosis (HP:0001718)3.53616197
16Complement deficiency (HP:0004431)3.43099432
17Prolonged partial thromboplastin time (HP:0003645)3.42631130
18Nuclear cataract (HP:0100018)3.40593209
19Recurrent abscess formation (HP:0002722)3.35294982
20Abnormality of the common coagulation pathway (HP:0010990)3.35086252
21Joint hemorrhage (HP:0005261)3.33145910
22Abnormality of the intrinsic pathway (HP:0010989)3.20497987
23Epidermoid cyst (HP:0200040)3.18653485
24Hyperlipoproteinemia (HP:0010980)3.18589183
25Hypochromic microcytic anemia (HP:0004840)3.18246171
26Tetraparesis (HP:0002273)3.17271051
27Fat malabsorption (HP:0002630)3.15830971
28Autoimmune thrombocytopenia (HP:0001973)3.14261205
29Systemic lupus erythematosus (HP:0002725)3.12749895
30Hyperglycemia (HP:0003074)3.07386099
31Hematochezia (HP:0002573)3.06119313
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01971504
33Abnormality of macrophages (HP:0004311)3.01405564
34Hypobetalipoproteinemia (HP:0003563)3.01156396
35Vacuolated lymphocytes (HP:0001922)2.99334835
36Progressive neurologic deterioration (HP:0002344)2.94976451
37Acanthocytosis (HP:0001927)2.93360594
38Pustule (HP:0200039)2.85429215
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.81219831
40Poikilocytosis (HP:0004447)2.79689759
41Double outlet right ventricle (HP:0001719)2.78518038
42Congenital malformation of the right heart (HP:0011723)2.78518038
43Premature rupture of membranes (HP:0001788)2.74782969
44Axonal loss (HP:0003447)2.73592370
45Gingival bleeding (HP:0000225)2.72878993
46Steatorrhea (HP:0002570)2.72834612
47Abnormality of complement system (HP:0005339)2.69402124
48Orchitis (HP:0100796)2.64349899
49Orthostatic hypotension (HP:0001278)2.62669315
50Postural tremor (HP:0002174)2.62353678
51Abnormality of iron homeostasis (HP:0011031)2.56262384
52Increased serum ferritin (HP:0003281)2.54223366
53Hydroxyprolinuria (HP:0003080)2.53963687
54Abnormality of proline metabolism (HP:0010907)2.53963687
55Hyperglycinemia (HP:0002154)2.53871147
56Abnormality of transition element cation homeostasis (HP:0011030)2.53535170
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52331080
58Hypercholesterolemia (HP:0003124)2.51962247
59Stomatitis (HP:0010280)2.50939201
60Optic neuritis (HP:0100653)2.50559328
61Retrobulbar optic neuritis (HP:0100654)2.50559328
62Follicular hyperkeratosis (HP:0007502)2.47371114
63Abnormality of purine metabolism (HP:0004352)2.45426276
64Zonular cataract (HP:0010920)2.45243555
65Hypolipoproteinemia (HP:0010981)2.45071415
66Abnormality of calcium-phosphate metabolism (HP:0100530)2.43075854
67Prostate neoplasm (HP:0100787)2.42779510
68Conjugated hyperbilirubinemia (HP:0002908)2.41948511
69Esophageal varix (HP:0002040)2.39816118
70Thick nail (HP:0001805)2.39076172
71Glomerulonephritis (HP:0000099)2.36862326
72Hepatocellular carcinoma (HP:0001402)2.36666803
73Increased cerebral lipofuscin (HP:0011813)2.34446316
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.34141129
75Abnormal enzyme/coenzyme activity (HP:0012379)2.34118265
76Albinism (HP:0001022)2.33565099
77Hyperglycinuria (HP:0003108)2.32544974
78Recurrent skin infections (HP:0001581)2.31943957
79Anorexia (HP:0002039)2.31625561
80Hypoalphalipoproteinemia (HP:0003233)2.31193530
81Metaphyseal dysplasia (HP:0100255)2.31078080
82Vascular calcification (HP:0004934)2.29338968
83Abnormality of nucleobase metabolism (HP:0010932)2.29144713
84Dysostosis multiplex (HP:0000943)2.25759933
85Vasculitis (HP:0002633)2.25647750
86Hypothermia (HP:0002045)2.24373663
87Reticulocytosis (HP:0001923)2.23844203
88Hypoglycemic seizures (HP:0002173)2.23697793
89Hyperbilirubinemia (HP:0002904)2.22718144
90Nausea (HP:0002018)2.22503485
91Elevated alkaline phosphatase (HP:0003155)2.22212496
92Urticaria (HP:0001025)2.22035508
93Abnormality of alkaline phosphatase activity (HP:0004379)2.21769185
94Proximal tubulopathy (HP:0000114)2.20338921
95Mucopolysacchariduria (HP:0008155)2.19919730
96Urinary glycosaminoglycan excretion (HP:0003541)2.19919730
97Abnormality of methionine metabolism (HP:0010901)2.19087032
98Gingivitis (HP:0000230)2.18913812
99Abnormal gallbladder morphology (HP:0012437)2.18114233
100Palmoplantar hyperkeratosis (HP:0000972)2.17748247
101Myositis (HP:0100614)2.16515893
102Plantar hyperkeratosis (HP:0007556)2.15989748
103Menorrhagia (HP:0000132)2.13580389
104Testicular neoplasm (HP:0010788)2.11276795
105Hypoglycemic coma (HP:0001325)2.10744459
106Loss of speech (HP:0002371)2.10661938
107Hemorrhage of the eye (HP:0011885)2.10142178
108Skin nodule (HP:0200036)2.10001427
109Polycythemia (HP:0001901)2.09914776
110Abnormality of serine family amino acid metabolism (HP:0010894)2.09372584
111Abnormality of glycine metabolism (HP:0010895)2.09372584
112Osteolytic defects of the hand bones (HP:0009699)2.09073726
113Osteolytic defects of the phalanges of the hand (HP:0009771)2.09073726
114Atrophic scars (HP:0001075)2.08440662
115Cholelithiasis (HP:0001081)2.07699660
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07527869
117Abnormality of polysaccharide metabolism (HP:0011012)2.07527869
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07527869
119Ketosis (HP:0001946)2.07237162
120Pancreatitis (HP:0001733)2.06796995
121Hyperammonemia (HP:0001987)2.06753473
122Cardiovascular calcification (HP:0011915)2.04929707
123Ovoid vertebral bodies (HP:0003300)2.03761648
124Pathologic fracture (HP:0002756)2.03124338
125Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02788787
126Intestinal atresia (HP:0011100)2.02465896
127Symptomatic seizures (HP:0011145)2.02051406
128Abnormality of vitamin metabolism (HP:0100508)2.01677994
129Episodic fever (HP:0001954)2.01434138
130Elevated erythrocyte sedimentation rate (HP:0003565)2.00586545
131Protuberant abdomen (HP:0001538)2.00136329
132Hypophosphatemic rickets (HP:0004912)1.99909939
133Enlarged penis (HP:0000040)1.99356474
134Hyperinsulinemic hypoglycemia (HP:0000825)1.99192079
135Mediastinal lymphadenopathy (HP:0100721)1.98122189
136Amyloidosis (HP:0011034)1.97293677
137Conjunctival hamartoma (HP:0100780)1.96104156
138Protrusio acetabuli (HP:0003179)1.95972036
139Cardiomegaly (HP:0001640)1.95145631
140Palmar hyperkeratosis (HP:0010765)1.93793056
141Vertebral compression fractures (HP:0002953)1.90824947
142Cervical subluxation (HP:0003308)1.90688343
143Late onset (HP:0003584)1.88488396
144Exocrine pancreatic insufficiency (HP:0001738)1.87632684
145Thoracolumbar scoliosis (HP:0002944)1.85851897
146Hyperphosphatemia (HP:0002905)1.85179776
147Irregular vertebral endplates (HP:0003301)1.84581153
148Urethral obstruction (HP:0000796)1.84191996
149Insulin-resistant diabetes mellitus (HP:0000831)1.83601455
150Malnutrition (HP:0004395)1.82413321
151Striae distensae (HP:0001065)1.80486178
152Arthropathy (HP:0003040)1.79124280
153Spondylolisthesis (HP:0003302)1.78827207
154Abnormality of vitamin B metabolism (HP:0004340)1.77845407
155Bone cyst (HP:0012062)1.77203619
156Hypoplasia of dental enamel (HP:0006297)1.75626622
157Right ventricular cardiomyopathy (HP:0011663)1.73286903
158Rickets (HP:0002748)1.72678893
159Menstrual irregularities (HP:0000858)1.70311725
160Hamartoma of the eye (HP:0010568)1.69482559
161Ketoacidosis (HP:0001993)1.69004484
162Hypoplasia of the odontoid process (HP:0003311)1.68926062
163Hypoalbuminemia (HP:0003073)1.67389104
164Abnormal albumin level (HP:0012116)1.67389104
165Asymmetry of the thorax (HP:0001555)1.66964788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.77872578
2IRAK33.77480433
3TAOK33.66247045
4ERN13.17973590
5TBK12.96534676
6TYK22.46877912
7IKBKB2.22838568
8IKBKE2.10083985
9ACVR1B2.07138442
10PBK1.98433348
11JAK11.94291851
12MYLK1.93693512
13JAK31.93446440
14STK31.93089378
15MAP3K91.92938546
16IRAK41.86755385
17LATS11.85767600
18BCKDK1.83926310
19RIPK41.81635921
20ERBB41.75895024
21FRK1.75194934
22FER1.71682160
23FGFR41.70854069
24CHUK1.70087653
25FGFR21.69038583
26EPHB11.68900422
27PIM21.65922089
28GRK11.65433687
29MAP3K31.63335085
30SIK11.62283174
31PAK31.60843129
32MAP3K121.59170802
33NEK91.53201593
34PHKG11.52026372
35PHKG21.52026372
36DAPK21.46949920
37PIM11.46121421
38ADRBK21.41408617
39MAP2K61.41303547
40CSK1.40838216
41JAK21.37250973
42MAP3K21.36565304
43INSRR1.34186499
44PTK21.34001899
45CDK121.33508470
46BMX1.33308558
47NME21.31839573
48TXK1.30279930
49PRKCE1.22826804
50PDGFRA1.19716731
51GRK71.18879190
52ABL21.18535969
53ERBB31.15737004
54EPHA31.12271942
55NLK1.09310600
56WNK41.08502201
57TAOK11.04556865
58MAP4K11.04002384
59PIK3CG1.02533677
60MARK31.02043790
61CAMKK20.99172800
62ZAP700.98232138
63CDK60.97246753
64CDC42BPA0.96727695
65FGFR30.96010604
66STK390.94872457
67BLK0.94201745
68KIT0.93928990
69STK40.93699757
70CAMK1D0.93470977
71FGR0.93304459
72MAPK110.93143963
73TRIB30.92993448
74IRAK10.91503667
75RPS6KA40.90786973
76PLK20.90079825
77FLT30.88979155
78MAP4K20.88039042
79MET0.87997215
80MOS0.86682547
81CAMK2D0.85545922
82NUAK10.84827516
83GSK3A0.84792210
84MST1R0.84703997
85NTRK30.83271303
86AKT30.82456763
87LIMK10.81741528
88MAP3K50.81436979
89PRKD20.81276391
90TRPM70.81269853
91LATS20.81134396
92PRKG20.80461506
93MAP2K30.75611027
94MAPKAPK30.75496332
95EIF2AK10.74981063
96PTK60.74016205
97MAP3K110.73760398
98HIPK20.73056719
99STK100.72632538
100RIPK10.70956314
101STK380.70387866
102CSF1R0.69838782
103WNK10.69159641
104PTK2B0.68909072
105ABL10.67764136
106MATK0.65775168
107EGFR0.65355192
108CAMK1G0.65125482
109PRKAA20.62457627
110STK38L0.62102215
111LYN0.62006510
112ARAF0.60849100
113TGFBR20.59916596
114DDR20.59605946
115EPHA20.59472283
116ICK0.59463428
117PDGFRB0.59278598
118MAP3K130.58691005
119SYK0.55922627
120PRKCI0.53688695
121HCK0.52498352
122MST40.51063643
123ROCK20.50201617
124PDPK10.48543095
125LCK0.47360860
126FGFR10.46396222
127EIF2AK30.45979737
128BMPR20.45146266
129PRKAA10.44465446
130ROCK10.43903058
131EIF2AK20.43531265
132SGK20.43503143
133PKN20.41669169
134STK240.41624074
135DYRK1B0.41168087
136ADRBK10.40818356
137CDK40.40771277
138MTOR0.40742170
139PAK20.40484045
140MELK0.40305826
141PAK40.39319286
142BRSK20.37888055
143MAP2K10.37653390
144MAP3K10.36734611
145MAPK150.36171014
146PRKCD0.35961376
147TAOK20.35744295
148TEC0.34515057
149PRKCQ0.33826996
150PDK10.33187605
151SGK30.32194118
152MAPKAPK20.30660626

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.00424308
2Staphylococcus aureus infection_Homo sapiens_hsa051502.81319975
3Complement and coagulation cascades_Homo sapiens_hsa046102.24386049
4Protein export_Homo sapiens_hsa030602.12521977
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12058365
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08337438
7Sphingolipid metabolism_Homo sapiens_hsa006002.01494967
8Arginine biosynthesis_Homo sapiens_hsa002201.99570448
9Vitamin B6 metabolism_Homo sapiens_hsa007501.97440091
10Mineral absorption_Homo sapiens_hsa049781.90227993
11Steroid biosynthesis_Homo sapiens_hsa001001.86212554
12Nitrogen metabolism_Homo sapiens_hsa009101.81287724
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79192930
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78600530
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.77551911
16Caffeine metabolism_Homo sapiens_hsa002321.75475654
17Leishmaniasis_Homo sapiens_hsa051401.66997624
18Folate biosynthesis_Homo sapiens_hsa007901.65602197
19Circadian rhythm_Homo sapiens_hsa047101.64277974
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.61158107
21Legionellosis_Homo sapiens_hsa051341.59456233
22Insulin secretion_Homo sapiens_hsa049111.58889838
23Tryptophan metabolism_Homo sapiens_hsa003801.58212632
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55302512
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53716883
26Malaria_Homo sapiens_hsa051441.49389062
27Selenocompound metabolism_Homo sapiens_hsa004501.46147508
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42425174
29PPAR signaling pathway_Homo sapiens_hsa033201.41426020
30Graft-versus-host disease_Homo sapiens_hsa053321.41376611
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38625570
32Peroxisome_Homo sapiens_hsa041461.37896857
33Fat digestion and absorption_Homo sapiens_hsa049751.35336344
34Histidine metabolism_Homo sapiens_hsa003401.30106093
35Vibrio cholerae infection_Homo sapiens_hsa051101.29538482
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29138831
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29044759
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28121454
39Fatty acid degradation_Homo sapiens_hsa000711.27840970
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25507371
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24124536
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21693936
43Dorso-ventral axis formation_Homo sapiens_hsa043201.21140834
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19985705
45Lysosome_Homo sapiens_hsa041421.18586773
46Collecting duct acid secretion_Homo sapiens_hsa049661.18488532
47Vitamin digestion and absorption_Homo sapiens_hsa049771.17667603
48TNF signaling pathway_Homo sapiens_hsa046681.17417936
49Measles_Homo sapiens_hsa051621.13907073
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13176003
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12991502
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11726227
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11430737
54Rheumatoid arthritis_Homo sapiens_hsa053231.11308910
55Osteoclast differentiation_Homo sapiens_hsa043801.10661328
56Chemical carcinogenesis_Homo sapiens_hsa052041.10415079
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.07030731
58Influenza A_Homo sapiens_hsa051641.05587848
59ABC transporters_Homo sapiens_hsa020101.04935299
60Sulfur metabolism_Homo sapiens_hsa009201.04924210
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.04342313
62beta-Alanine metabolism_Homo sapiens_hsa004101.03249137
63Allograft rejection_Homo sapiens_hsa053301.02148991
64Drug metabolism - other enzymes_Homo sapiens_hsa009831.01791502
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01118132
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00600997
67Pertussis_Homo sapiens_hsa051330.99905727
68Renin secretion_Homo sapiens_hsa049240.99822911
69Tuberculosis_Homo sapiens_hsa051520.99306018
70ECM-receptor interaction_Homo sapiens_hsa045120.97894600
71N-Glycan biosynthesis_Homo sapiens_hsa005100.94447954
72Starch and sucrose metabolism_Homo sapiens_hsa005000.92463577
73Retinol metabolism_Homo sapiens_hsa008300.92376576
74Fatty acid metabolism_Homo sapiens_hsa012120.91945711
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91557382
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89677932
77Fatty acid biosynthesis_Homo sapiens_hsa000610.89379577
78Ether lipid metabolism_Homo sapiens_hsa005650.89153383
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.87791767
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87001818
81Glucagon signaling pathway_Homo sapiens_hsa049220.84064287
82Pancreatic secretion_Homo sapiens_hsa049720.79754102
83Sulfur relay system_Homo sapiens_hsa041220.79651417
84Type I diabetes mellitus_Homo sapiens_hsa049400.78228805
85Herpes simplex infection_Homo sapiens_hsa051680.77459516
86Proteoglycans in cancer_Homo sapiens_hsa052050.76218486
87Asthma_Homo sapiens_hsa053100.76142699
88African trypanosomiasis_Homo sapiens_hsa051430.74985146
89Hepatitis C_Homo sapiens_hsa051600.74695723
90Arginine and proline metabolism_Homo sapiens_hsa003300.73961767
91Phagosome_Homo sapiens_hsa041450.73957831
92Phenylalanine metabolism_Homo sapiens_hsa003600.73718636
93Protein digestion and absorption_Homo sapiens_hsa049740.72837761
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71617464
95Propanoate metabolism_Homo sapiens_hsa006400.70329262
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70318463
97Toxoplasmosis_Homo sapiens_hsa051450.70023393
98Butanoate metabolism_Homo sapiens_hsa006500.68702874
99Focal adhesion_Homo sapiens_hsa045100.68506836
100Thyroid hormone synthesis_Homo sapiens_hsa049180.68375249
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68089989
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67827394
103Apoptosis_Homo sapiens_hsa042100.66158768
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64686885
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64669115
106Hematopoietic cell lineage_Homo sapiens_hsa046400.64397207
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.63373808
108Insulin resistance_Homo sapiens_hsa049310.62508117
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.62233805
110Glycerolipid metabolism_Homo sapiens_hsa005610.62071533
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60020011
112Renin-angiotensin system_Homo sapiens_hsa046140.59933469
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.59630112
114Type II diabetes mellitus_Homo sapiens_hsa049300.56886545
115Bile secretion_Homo sapiens_hsa049760.56387773
116B cell receptor signaling pathway_Homo sapiens_hsa046620.54918967
117Prion diseases_Homo sapiens_hsa050200.53307093
118Hepatitis B_Homo sapiens_hsa051610.49478171
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.48268523
120Pentose phosphate pathway_Homo sapiens_hsa000300.47436476
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47265544
122Glutathione metabolism_Homo sapiens_hsa004800.47139665
123Fatty acid elongation_Homo sapiens_hsa000620.45808226
124One carbon pool by folate_Homo sapiens_hsa006700.45644379
125Amoebiasis_Homo sapiens_hsa051460.45336615
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.44634773
127TGF-beta signaling pathway_Homo sapiens_hsa043500.44029928
128Regulation of autophagy_Homo sapiens_hsa041400.43418778
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43133553
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41512978
131Inositol phosphate metabolism_Homo sapiens_hsa005620.40410478
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39557959
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39464874
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39369407
135Tyrosine metabolism_Homo sapiens_hsa003500.39351265
136Prolactin signaling pathway_Homo sapiens_hsa049170.39237601
137Other glycan degradation_Homo sapiens_hsa005110.39211192
138GnRH signaling pathway_Homo sapiens_hsa049120.36594851
139Long-term depression_Homo sapiens_hsa047300.35663518
140Synaptic vesicle cycle_Homo sapiens_hsa047210.34468876
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33966655
142Salmonella infection_Homo sapiens_hsa051320.33866168
143Bladder cancer_Homo sapiens_hsa052190.32326099

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