ELL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)9.47671492
2sensory perception of smell (GO:0007608)9.11537506
3centriole replication (GO:0007099)7.06564457
4dosage compensation (GO:0007549)6.98533262
5regulation of double-strand break repair via homologous recombination (GO:0010569)6.86968492
6negative regulation of transcription regulatory region DNA binding (GO:2000678)6.68191893
7olfactory bulb development (GO:0021772)6.58819288
8B cell receptor signaling pathway (GO:0050853)6.53694953
9sensory perception of chemical stimulus (GO:0007606)6.43667626
10regulation of cilium movement (GO:0003352)6.34740510
11protein insertion into membrane (GO:0051205)6.04191725
12modulation by virus of host process (GO:0019054)6.02508613
13natural killer cell mediated immunity (GO:0002228)5.99095556
14natural killer cell mediated cytotoxicity (GO:0042267)5.99095556
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.92871685
16somatic hypermutation of immunoglobulin genes (GO:0016446)5.92871685
17cellular response to virus (GO:0098586)5.53945667
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.48113979
19centriole assembly (GO:0098534)5.26517557
20keratinocyte development (GO:0003334)5.13157055
21adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.95595070
22protein localization to cilium (GO:0061512)4.95402999
23phosphorelay signal transduction system (GO:0000160)4.88313678
24eyelid development in camera-type eye (GO:0061029)4.84990423
25germinal center formation (GO:0002467)4.83305936
26protein polyglutamylation (GO:0018095)4.80358857
27synaptonemal complex assembly (GO:0007130)4.79587993
28mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.69053685
29positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.69053685
30regulation of hippo signaling (GO:0035330)4.68654337
31synaptonemal complex organization (GO:0070193)4.53732407
32intraciliary transport (GO:0042073)4.49010832
33B cell proliferation (GO:0042100)4.47731830
34barbed-end actin filament capping (GO:0051016)4.44452824
35regulation of centriole replication (GO:0046599)4.43036482
36positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.35677093
37modulation by symbiont of host cellular process (GO:0044068)4.33174300
38nucleosome disassembly (GO:0006337)4.27579334
39protein-DNA complex disassembly (GO:0032986)4.27579334
40adipose tissue development (GO:0060612)4.24393296
41DNA unwinding involved in DNA replication (GO:0006268)4.17509265
42detection of calcium ion (GO:0005513)4.16672595
43organelle disassembly (GO:1903008)4.16229944
44male meiosis (GO:0007140)4.15426051
45endocrine hormone secretion (GO:0060986)4.05730307
46histone H2B ubiquitination (GO:0033523)4.03818847
47protein localization to chromosome (GO:0034502)4.03162385
48neuronal action potential (GO:0019228)4.01319042
49regulation of G0 to G1 transition (GO:0070316)4.01302331
50negative regulation of execution phase of apoptosis (GO:1900118)3.92405020
51somatic diversification of immunoglobulins (GO:0016445)3.89461526
52DNA strand elongation involved in DNA replication (GO:0006271)3.89351908
53microtubule severing (GO:0051013)3.88191929
54positive regulation of mitochondrial membrane permeability (GO:0035794)3.85266120
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.83849989
56regulation of double-strand break repair (GO:2000779)3.82766231
57DNA strand elongation (GO:0022616)3.81750040
58hepatocyte apoptotic process (GO:0097284)3.80828011
59cornea development in camera-type eye (GO:0061303)3.78898330
60telomere maintenance via semi-conservative replication (GO:0032201)3.76953453
61protein localization to chromosome, centromeric region (GO:0071459)3.71558707
62nuclear pore complex assembly (GO:0051292)3.70993684
63microtubule bundle formation (GO:0001578)3.66536710
64sensory perception of taste (GO:0050909)3.64525631
65ribosomal small subunit biogenesis (GO:0042274)3.63421311
66regulation of transcription regulatory region DNA binding (GO:2000677)3.60543390
67desmosome organization (GO:0002934)3.59101742
68DNA topological change (GO:0006265)3.56224961
69positive regulation of B cell differentiation (GO:0045579)3.55757215
70ribonucleoprotein complex disassembly (GO:0032988)3.50908001
71axoneme assembly (GO:0035082)3.49865315
72mitotic sister chromatid cohesion (GO:0007064)3.48433613
73telomere maintenance via recombination (GO:0000722)3.46104805
74folic acid-containing compound biosynthetic process (GO:0009396)3.39295989
75regulation of histone H3-K9 methylation (GO:0051570)3.36820717
76ganglion development (GO:0061548)3.35851085
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.35205124
78negative regulation of DNA-templated transcription, elongation (GO:0032785)3.35205124
79regulation of microtubule-based movement (GO:0060632)3.34298812
80mitotic recombination (GO:0006312)3.32589825
81regulation of interferon-beta biosynthetic process (GO:0045357)3.31646235
82somatic recombination of immunoglobulin gene segments (GO:0016447)3.30647179
83antibacterial humoral response (GO:0019731)3.29325242
84lactate metabolic process (GO:0006089)3.28623316
85male genitalia development (GO:0030539)3.23251984
86regulation of glucocorticoid metabolic process (GO:0031943)3.22192384
87cilium morphogenesis (GO:0060271)3.21368081
88innate immune response in mucosa (GO:0002227)3.20019103
89regulation of interferon-gamma biosynthetic process (GO:0045072)3.19823801
90protein localization to kinetochore (GO:0034501)3.18384188
91brain morphogenesis (GO:0048854)3.17334213
92extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)3.12483546
93signal transduction in absence of ligand (GO:0038034)3.12483546
94positive regulation of oligodendrocyte differentiation (GO:0048714)3.10093770
95cellular response to prostaglandin stimulus (GO:0071379)3.09187318
96T cell lineage commitment (GO:0002360)3.09171301
97somatic diversification of immune receptors (GO:0002200)3.08382629
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.07728981
99nuclear pore organization (GO:0006999)3.07349737
100receptor guanylyl cyclase signaling pathway (GO:0007168)3.06955923
101mitotic chromosome condensation (GO:0007076)3.05499351
102mitotic sister chromatid segregation (GO:0000070)3.04985718
103antimicrobial humoral response (GO:0019730)3.01945552
104microtubule polymerization or depolymerization (GO:0031109)3.01360534
105regulation of execution phase of apoptosis (GO:1900117)2.99332408
106homeostasis of number of cells within a tissue (GO:0048873)2.98527573
107nucleotide-excision repair, DNA gap filling (GO:0006297)2.96739004
108telomere maintenance via telomere lengthening (GO:0010833)2.96184375
109DNA integration (GO:0015074)2.95518883
110transcription elongation from RNA polymerase III promoter (GO:0006385)2.93543506
111termination of RNA polymerase III transcription (GO:0006386)2.93543506
112formation of translation preinitiation complex (GO:0001731)2.93047066
113glial cell proliferation (GO:0014009)2.90486337
114meiotic chromosome segregation (GO:0045132)2.90191367
115base-excision repair (GO:0006284)2.89198772
116pyrimidine nucleotide catabolic process (GO:0006244)2.89146320
117sister chromatid segregation (GO:0000819)2.86057799
118regulation of translational fidelity (GO:0006450)2.85571163
119axonemal dynein complex assembly (GO:0070286)2.83843922
120neurofilament cytoskeleton organization (GO:0060052)2.83440018
121vesicle targeting (GO:0006903)2.82135498
122mitochondrial DNA metabolic process (GO:0032042)2.81927511
123ovulation cycle (GO:0042698)2.81666339
124regulation of B cell differentiation (GO:0045577)2.81662719
125cilium assembly (GO:0042384)2.81302676
126sympathetic nervous system development (GO:0048485)2.80778603
127regulation of histone H3-K27 methylation (GO:0061085)2.80644416
128proline biosynthetic process (GO:0006561)2.80536266
129modulation by virus of host morphology or physiology (GO:0019048)2.79506123
130regulation of female gonad development (GO:2000194)2.79202043
131mitochondrial DNA replication (GO:0006264)2.78957053
132establishment of skin barrier (GO:0061436)2.78341873
133regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.78013060
134release of cytochrome c from mitochondria (GO:0001836)2.77693649
135negative regulation of microtubule polymerization (GO:0031115)2.77693189
136diol metabolic process (GO:0034311)2.77652878
137iron-sulfur cluster assembly (GO:0016226)2.76316602
138metallo-sulfur cluster assembly (GO:0031163)2.76316602
139positive regulation of chromosome segregation (GO:0051984)2.75860658
140leukocyte mediated cytotoxicity (GO:0001909)2.74085366
141DNA duplex unwinding (GO:0032508)2.73377700
142viral transcription (GO:0019083)2.72815929
143neural tube formation (GO:0001841)2.71377043
144positive regulation of protein homooligomerization (GO:0032464)2.71062718
145negative regulation of defense response to virus (GO:0050687)2.71048829
146somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.70581980
147somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.70581980
148isotype switching (GO:0045190)2.70581980
149regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.70119556
150mucosal immune response (GO:0002385)2.67987861
151cilium organization (GO:0044782)2.64743810
152translational termination (GO:0006415)2.64339809
153regulation of DNA repair (GO:0006282)2.63937016
154telomere organization (GO:0032200)2.62885442
155behavioral response to pain (GO:0048266)2.61998897
156DNA geometric change (GO:0032392)2.61855585
157auditory receptor cell differentiation (GO:0042491)2.61413868
158positive regulation of interferon-alpha production (GO:0032727)2.61334681
159regulation of DNA endoreduplication (GO:0032875)2.61263119
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61103519
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61103519
162positive regulation of mitotic sister chromatid separation (GO:1901970)2.61103519
163telomere maintenance (GO:0000723)2.61077101
164negative regulation of histone methylation (GO:0031061)2.60478863
165somatic cell DNA recombination (GO:0016444)2.60020003
166somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60020003
167positive thymic T cell selection (GO:0045059)2.59177845
168ribosomal small subunit assembly (GO:0000028)2.59177794
169pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.59040537
170replicative senescence (GO:0090399)2.57883774
171positive regulation of B cell proliferation (GO:0030890)2.57723497
172sphingosine metabolic process (GO:0006670)2.57621754
173NADH metabolic process (GO:0006734)2.57406337
174DNA replication initiation (GO:0006270)2.56067218
175RNA-dependent DNA replication (GO:0006278)2.55454258
176negative regulation of T cell differentiation (GO:0045581)2.55152981
177ribonucleoprotein complex biogenesis (GO:0022613)2.53831137
178positive regulation of gamma-delta T cell activation (GO:0046645)2.53031609
179regulation of water loss via skin (GO:0033561)2.52772996
180ribosome biogenesis (GO:0042254)2.50905567
181pore complex assembly (GO:0046931)2.50045761
182nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49001381
183positive regulation of protein oligomerization (GO:0032461)2.47619147
184DNA replication checkpoint (GO:0000076)2.46760770
185attachment of spindle microtubules to kinetochore (GO:0008608)2.46078785
186deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.45971636
187pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45208716
188regulation of gamma-delta T cell differentiation (GO:0045586)2.42588373
189maturation of SSU-rRNA (GO:0030490)2.42172320
190DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.39619675
191DNA conformation change (GO:0071103)2.39580772
192translational elongation (GO:0006414)2.39066889
193regulation of sister chromatid cohesion (GO:0007063)2.38278367
194positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.36832229
195regulation of interferon-alpha production (GO:0032647)2.35733508
196regulation of chromatin binding (GO:0035561)10.8659244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.94330036
2E2F7_22180533_ChIP-Seq_HELA_Human6.93405449
3RBPJ_22232070_ChIP-Seq_NCS_Mouse6.03363509
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.91614959
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31505162
6ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse4.16671974
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.27308537
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18470698
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15454492
10TP63_19390658_ChIP-ChIP_HaCaT_Human3.03706285
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.99412941
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93805972
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91491840
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73312330
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63558295
16BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.62190242
17ZNF263_19887448_ChIP-Seq_K562_Human2.60280219
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.58908272
19SOX2_18555785_ChIP-Seq_MESCs_Mouse2.55100211
20* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49657929
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34816809
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33872831
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33569508
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18520848
25* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13762313
26AHR_22903824_ChIP-Seq_MCF-7_Human2.06891198
27RUNX1_26923725_Chip-Seq_HPCs_Mouse2.05848031
28XRN2_22483619_ChIP-Seq_HELA_Human2.03383435
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01830014
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00394394
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99437248
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96838444
33AR_21909140_ChIP-Seq_LNCAP_Human1.91656358
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87547441
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85657550
36SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.80456641
37VDR_21846776_ChIP-Seq_THP-1_Human1.76092747
38DCP1A_22483619_ChIP-Seq_HELA_Human1.75218070
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.69375098
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69134550
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68834845
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.67206138
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66228845
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65143034
45PHF8_20622854_ChIP-Seq_HELA_Human1.63553252
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62905695
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60491474
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60403233
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54671231
50* GATA3_21867929_ChIP-Seq_TH1_Mouse1.52214855
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49268099
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47075752
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.41796151
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40876991
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40850321
56* VDR_23849224_ChIP-Seq_CD4+_Human1.40797452
57TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40646990
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38585148
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37941149
60FOXP3_21729870_ChIP-Seq_TREG_Human1.37657917
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36907976
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36907976
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34696633
64RACK7_27058665_Chip-Seq_MCF-7_Human1.34219918
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33924329
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33215796
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32498494
68BCOR_27268052_Chip-Seq_Bcells_Human1.31988913
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.31466299
70TAF15_26573619_Chip-Seq_HEK293_Human1.29269028
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28365762
72ERA_21632823_ChIP-Seq_H3396_Human1.25450571
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.25381655
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.25351940
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25116865
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25111300
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24623219
78KDM5A_27292631_Chip-Seq_BREAST_Human1.21897556
79* E2F1_21310950_ChIP-Seq_MCF-7_Human1.21397769
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.21303899
81TTF2_22483619_ChIP-Seq_HELA_Human1.20776930
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19693289
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19669052
84* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18387352
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18193910
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17471647
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17123936
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15581640
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15200305
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14935694
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14485499
92MAF_26560356_Chip-Seq_TH2_Human1.14049949
93CHD1_26751641_Chip-Seq_LNCaP_Human1.12951163
94* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11735980
95SRF_21415370_ChIP-Seq_HL-1_Mouse1.11334275
96MYB_26560356_Chip-Seq_TH1_Human1.10784558
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10572171
98P300_27268052_Chip-Seq_Bcells_Human1.10562082
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10188981
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10173528
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09400499
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08920862
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06686660
104POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06338685
105SPI1_23547873_ChIP-Seq_NB4_Human1.05986929
106TFEB_21752829_ChIP-Seq_HELA_Human1.05277461
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.05130273
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04521734
109ELF5_23300383_ChIP-Seq_T47D_Human1.03181176
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03102065
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.03004665
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01583152
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00467020
114UTX_26944678_Chip-Seq_JUKART_Human1.00351883
115MAF_26560356_Chip-Seq_TH1_Human1.00292914
116RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98947649
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97743845
118CIITA_25753668_ChIP-Seq_RAJI_Human0.97068066
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96992213
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96759580
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95455406
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94591920
123TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94447434
124GF1_26923725_Chip-Seq_HPCs_Mouse0.93992673
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93745372
126CTCF_20526341_ChIP-Seq_ESCs_Human0.93547732
127MYC_22102868_ChIP-Seq_BL_Human0.93180240
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93069514
129* RARB_24833708_ChIP-Seq_LIVER_Mouse0.92364267
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91700568
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91067600
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90965417
133WDR5_24793694_ChIP-Seq_LNCAP_Human0.90896914
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.90061431
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89465679
136TP63_17297297_ChIP-ChIP_HaCaT_Human0.89209837
137MYB_26560356_Chip-Seq_TH2_Human0.89066619
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88953934
139OCT4_20526341_ChIP-Seq_ESCs_Human0.88108120
140* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87912759
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87853251
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87604958
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.86334062
144FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85889732
145E2F1_20622854_ChIP-Seq_HELA_Human0.85856921
146GATA3_21867929_ChIP-Seq_CD8_Mouse0.85593168
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85570616
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85337095
149NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85175178
150PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84588438
151CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84373440
152CEBPB_22108803_ChIP-Seq_LS180_Human0.84263454
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83608191
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82978458
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82799940
156VDR_22108803_ChIP-Seq_LS180_Human0.82595716
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81190493
158CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80810754
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80671755
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80648557
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80575676
162GABP_19822575_ChIP-Seq_HepG2_Human0.80129594
163VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79706170
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79408055
165RING1B_27294783_Chip-Seq_ESCs_Mouse0.79078641
166CDX2_22108803_ChIP-Seq_LS180_Human0.79077906
167* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.78905045
168TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78055947
169NANOG_21062744_ChIP-ChIP_HESCs_Human0.77176709
170HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76747503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium7.29379142
2MP0005499_abnormal_olfactory_system6.25952474
3MP0005394_taste/olfaction_phenotype6.25952474
4MP0001984_abnormal_olfaction5.58363691
5MP0003787_abnormal_imprinting5.16794242
6MP0008057_abnormal_DNA_replication3.80848502
7MP0005645_abnormal_hypothalamus_physiol3.52970933
8MP0008877_abnormal_DNA_methylation3.44060156
9MP0003111_abnormal_nucleus_morphology2.86521563
10MP0001986_abnormal_taste_sensitivity2.85133799
11MP0001485_abnormal_pinna_reflex2.77721163
12MP0003878_abnormal_ear_physiology2.77113698
13MP0005377_hearing/vestibular/ear_phenot2.77113698
14MP0003693_abnormal_embryo_hatching2.59711626
15MP0001800_abnormal_humoral_immune2.58289477
16MP0003077_abnormal_cell_cycle2.51624516
17MP0001790_abnormal_immune_system2.37997686
18MP0005387_immune_system_phenotype2.37997686
19MP0002160_abnormal_reproductive_system2.36841203
20MP0001835_abnormal_antigen_presentation2.36304114
21MP0004885_abnormal_endolymph2.22467363
22MP0001293_anophthalmia2.22228833
23MP0005187_abnormal_penis_morphology2.22178379
24MP0008058_abnormal_DNA_repair2.20592032
25MP0000372_irregular_coat_pigmentation2.14294609
26MP0002102_abnormal_ear_morphology2.13154927
27MP0005310_abnormal_salivary_gland2.12855231
28MP0010678_abnormal_skin_adnexa2.10368332
29MP0001542_abnormal_bone_strength2.04985070
30MP0005423_abnormal_somatic_nervous1.94580949
31MP0004264_abnormal_extraembryonic_tissu1.91344490
32MP0000383_abnormal_hair_follicle1.89373313
33MP0001661_extended_life_span1.87074084
34MP0000685_abnormal_immune_system1.86339634
35MP0002233_abnormal_nose_morphology1.86079465
36MP0002132_abnormal_respiratory_system1.82984606
37MP0000537_abnormal_urethra_morphology1.80549299
38MP0002452_abnormal_antigen_presenting1.80117734
39MP0003121_genomic_imprinting1.79337805
40MP0005000_abnormal_immune_tolerance1.78836144
41MP0005408_hypopigmentation1.73775051
42MP0002396_abnormal_hematopoietic_system1.71812454
43MP0003786_premature_aging1.71055557
44MP0002009_preneoplasia1.70169684
45MP0004742_abnormal_vestibular_system1.67857628
46MP0003941_abnormal_skin_development1.58304038
47MP0002398_abnormal_bone_marrow1.52570885
48MP0002166_altered_tumor_susceptibility1.45952068
49MP0000003_abnormal_adipose_tissue1.43287881
50MP0000647_abnormal_sebaceous_gland1.42922413
51MP0002184_abnormal_innervation1.41272004
52MP0001873_stomach_inflammation1.40666752
53MP0003763_abnormal_thymus_physiology1.39598778
54MP0002723_abnormal_immune_serum1.39054299
55MP0000689_abnormal_spleen_morphology1.38901335
56MP0001666_abnormal_nutrient_absorption1.38228048
57MP0005389_reproductive_system_phenotype1.35531820
58MP0002796_impaired_skin_barrier1.34259464
59MP0002420_abnormal_adaptive_immunity1.34100610
60MP0010234_abnormal_vibrissa_follicle1.33684230
61MP0003806_abnormal_nucleotide_metabolis1.30119284
62MP0010386_abnormal_urinary_bladder1.26733475
63MP0001730_embryonic_growth_arrest1.26666376
64MP0000313_abnormal_cell_death1.26498709
65MP0001346_abnormal_lacrimal_gland1.24736507
66MP0002019_abnormal_tumor_incidence1.24176772
67MP0001819_abnormal_immune_cell1.23887110
68MP0003315_abnormal_perineum_morphology1.23441534
69MP0010307_abnormal_tumor_latency1.22842158
70MP0000013_abnormal_adipose_tissue1.20903099
71MP0000716_abnormal_immune_system1.20396161
72MP0008932_abnormal_embryonic_tissue1.19437553
73MP0002722_abnormal_immune_system1.14643128
74MP0002139_abnormal_hepatobiliary_system1.14193276
75MP0008007_abnormal_cellular_replicative1.11259413
76MP0000579_abnormal_nail_morphology1.06359386
77MP0002092_abnormal_eye_morphology1.06202975
78MP0004808_abnormal_hematopoietic_stem1.05870843
79MP0002429_abnormal_blood_cell1.04981597
80MP0010155_abnormal_intestine_physiology1.03075598
81MP0001286_abnormal_eye_development1.02229167
82MP0003183_abnormal_peptide_metabolism1.01618750
83MP0010352_gastrointestinal_tract_polyps0.98741717
84MP0006036_abnormal_mitochondrial_physio0.98194005
85MP0009379_abnormal_foot_pigmentation0.97636783
86MP0000778_abnormal_nervous_system0.95209715
87MP0004381_abnormal_hair_follicle0.93594730
88MP0002210_abnormal_sex_determination0.93395161
89MP0002752_abnormal_somatic_nervous0.93059095
90MP0005174_abnormal_tail_pigmentation0.91594321
91MP0008260_abnormal_autophagy0.91266695
92MP0001216_abnormal_epidermal_layer0.89593618
93MP0002136_abnormal_kidney_physiology0.89047132
94MP0009333_abnormal_splenocyte_physiolog0.88525767
95MP0001963_abnormal_hearing_physiology0.88408859
96MP0006276_abnormal_autonomic_nervous0.88167972
97MP0000026_abnormal_inner_ear0.87934956
98MP0003984_embryonic_growth_retardation0.87289102
99MP0001324_abnormal_eye_pigmentation0.86667476
100MP0003718_maternal_effect0.86495042
101MP0000538_abnormal_urinary_bladder0.85948407
102MP0001119_abnormal_female_reproductive0.85739911
103MP0005380_embryogenesis_phenotype0.85521010
104MP0001672_abnormal_embryogenesis/_devel0.85521010
105MP0003303_peritoneal_inflammation0.84216162
106MP0003453_abnormal_keratinocyte_physiol0.83534389
107MP0005379_endocrine/exocrine_gland_phen0.83337415
108MP0002751_abnormal_autonomic_nervous0.83294783
109MP0002006_tumorigenesis0.82672825
110MP0000703_abnormal_thymus_morphology0.82513645
111MP0001697_abnormal_embryo_size0.82124234
112MP0002088_abnormal_embryonic_growth/wei0.81660141
113MP0000627_abnormal_mammary_gland0.81541355
114MP0009703_decreased_birth_body0.81125672
115MP0003861_abnormal_nervous_system0.80731624
116MP0004947_skin_inflammation0.79401303
117MP0001845_abnormal_inflammatory_respons0.79186971
118MP0004270_analgesia0.78641527
119MP0001764_abnormal_homeostasis0.77900773
120MP0002405_respiratory_system_inflammati0.77798762
121MP0002938_white_spotting0.77791378
122MP0004134_abnormal_chest_morphology0.77631774
123MP0010094_abnormal_chromosome_stability0.77115660
124MP0002254_reproductive_system_inflammat0.74094849
125MP0000427_abnormal_hair_cycle0.73814470
126MP0006035_abnormal_mitochondrial_morpho0.73808827
127MP0002080_prenatal_lethality0.71745937
128MP0000609_abnormal_liver_physiology0.71471428
129MP0005220_abnormal_exocrine_pancreas0.71196621
130MP0002098_abnormal_vibrissa_morphology0.71175826
131MP0005084_abnormal_gallbladder_morpholo0.70261629
132MP0001853_heart_inflammation0.69920750
133MP0006292_abnormal_olfactory_placode0.69354306
134MP0005332_abnormal_amino_acid0.68938021
135MP0001929_abnormal_gametogenesis0.68627247
136MP0005365_abnormal_bile_salt0.68621498
137MP0001881_abnormal_mammary_gland0.68421095
138MP0002557_abnormal_social/conspecific_i0.68327056
139MP0009672_abnormal_birth_weight0.68041156
140MP0004185_abnormal_adipocyte_glucose0.67960324
141MP0002138_abnormal_hepatobiliary_system0.66267225
142MP0002249_abnormal_larynx_morphology0.65209897
143MP0005501_abnormal_skin_physiology0.64343476
144MP0000653_abnormal_sex_gland0.62733404
145MP0002277_abnormal_respiratory_mucosa0.60839257
146MP0002882_abnormal_neuron_morphology0.60434928
147MP0002877_abnormal_melanocyte_morpholog0.60108719
148MP0000049_abnormal_middle_ear0.60013582
149MP0001145_abnormal_male_reproductive0.58080799
150MP0002152_abnormal_brain_morphology0.57298522
151MP0005367_renal/urinary_system_phenotyp0.57157863
152MP0000516_abnormal_urinary_system0.57157863
153MP0002081_perinatal_lethality0.52427334
154MP0000377_abnormal_hair_follicle0.50590211
155MP0005075_abnormal_melanosome_morpholog0.48682129
156MP0000350_abnormal_cell_proliferation0.47188808
157MP0004133_heterotaxia0.46708719
158MP0005451_abnormal_body_composition0.46620597
159MP0000490_abnormal_crypts_of0.45995446
160MP0001849_ear_inflammation0.45632421
161MP0002697_abnormal_eye_size0.45273086
162MP0004957_abnormal_blastocyst_morpholog0.45165574
163MP0008995_early_reproductive_senescence0.45008455
164MP0000631_abnormal_neuroendocrine_gland0.44830712
165MP0003755_abnormal_palate_morphology0.44734295
166MP0005193_abnormal_anterior_eye0.42838239
167MP0004858_abnormal_nervous_system0.40965776
168MP0000613_abnormal_salivary_gland0.39437472
169MP0005171_absent_coat_pigmentation0.39162953
170MP0005391_vision/eye_phenotype0.38663342
171MP0003195_calcinosis0.37120130
172MP0008875_abnormal_xenobiotic_pharmacok0.37101289
173MP0003698_abnormal_male_reproductive0.36618120
174MP0005360_urolithiasis0.36266427
175MP0000015_abnormal_ear_pigmentation0.36113278
176MP0009765_abnormal_xenobiotic_induced0.35646242

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)6.52850998
2Abnormality of cochlea (HP:0000375)6.33377508
3Agammaglobulinemia (HP:0004432)6.25215563
4Pelvic girdle muscle weakness (HP:0003749)5.99709953
5Anosmia (HP:0000458)5.49852146
6Pili torti (HP:0003777)5.46914639
7Abnormality of the musculature of the pelvis (HP:0001469)5.15395619
8Abnormality of the hip-girdle musculature (HP:0001445)5.15395619
9Recurrent bronchitis (HP:0002837)4.53498327
10Morphological abnormality of the inner ear (HP:0011390)4.28177829
11Xerostomia (HP:0000217)4.26705549
12Febrile seizures (HP:0002373)3.97444410
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.92389897
14Abnormal hair laboratory examination (HP:0003328)3.91138869
15Abnormality of macular pigmentation (HP:0008002)3.78161132
16Colitis (HP:0002583)3.77887434
17Abnormality of the intervertebral disk (HP:0005108)3.77876770
18Atonic seizures (HP:0010819)3.68402593
19Chromsome breakage (HP:0040012)3.58762281
20Pancreatic fibrosis (HP:0100732)3.57968552
21Medial flaring of the eyebrow (HP:0010747)3.57223090
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51987396
23Progressive external ophthalmoplegia (HP:0000590)3.49799877
24Lymphopenia (HP:0001888)3.47261660
25Palpebral edema (HP:0100540)3.45845208
26Panhypogammaglobulinemia (HP:0003139)3.41060963
27Gait imbalance (HP:0002141)3.36894206
28Congenital primary aphakia (HP:0007707)3.33336569
29Aplasia/Hypoplasia of the patella (HP:0006498)3.32281532
30IgA deficiency (HP:0002720)3.31320697
31Palpitations (HP:0001962)3.31278101
32Cellulitis (HP:0100658)3.30704346
33Nephrogenic diabetes insipidus (HP:0009806)3.27756440
34Bronchitis (HP:0012387)3.25581297
35Emphysema (HP:0002097)3.23485050
36Patellar aplasia (HP:0006443)3.19967376
37Facial cleft (HP:0002006)3.16904148
38Sparse lateral eyebrow (HP:0005338)3.15374247
39Abnormality of midbrain morphology (HP:0002418)3.14222632
40Molar tooth sign on MRI (HP:0002419)3.14222632
41Abnormal respiratory motile cilium physiology (HP:0012261)3.14094156
42Abnormality of cells of the lymphoid lineage (HP:0012140)3.10151978
43Hypochromic microcytic anemia (HP:0004840)3.07704746
44Papilloma (HP:0012740)3.04131220
45Verrucae (HP:0200043)3.04131220
46Limb hypertonia (HP:0002509)2.91901439
47Recurrent sinusitis (HP:0011108)2.91707765
48Median cleft lip (HP:0000161)2.91152053
49Lymphoma (HP:0002665)2.88055838
50Hypoplasia of the thymus (HP:0000778)2.86898891
51Abnormality of chromosome stability (HP:0003220)2.86469702
52Villous atrophy (HP:0011473)2.83897663
53Abnormality of small intestinal villus morphology (HP:0011472)2.83897663
54Recurrent viral infections (HP:0004429)2.82685843
55Reticulocytopenia (HP:0001896)2.81138213
56Curly hair (HP:0002212)2.78112797
57Poor coordination (HP:0002370)2.77509466
58Cone-rod dystrophy (HP:0000548)2.74352338
59Slow-growing hair (HP:0002217)2.72894693
60Abnormality of hair growth rate (HP:0011363)2.72894693
61True hermaphroditism (HP:0010459)2.71691902
62Mask-like facies (HP:0000298)2.71048496
63Abnormality of the preputium (HP:0100587)2.70839837
64Gastrointestinal inflammation (HP:0004386)2.68963870
65Abnormal ciliary motility (HP:0012262)2.68091831
66Breast aplasia (HP:0100783)2.67892658
67Bifid tongue (HP:0010297)2.67171405
68Genital tract atresia (HP:0001827)2.64923440
69Medulloblastoma (HP:0002885)2.64496226
70IgM deficiency (HP:0002850)2.63255075
71Squamous cell carcinoma (HP:0002860)2.61226480
72Decreased central vision (HP:0007663)2.60736225
73Poikiloderma (HP:0001029)2.58294909
74Vaginal atresia (HP:0000148)2.56210134
75Inflammation of the large intestine (HP:0002037)2.55052531
76Abnormal respiratory epithelium morphology (HP:0012253)2.54693648
77Abnormal respiratory motile cilium morphology (HP:0005938)2.54693648
78Meningitis (HP:0001287)2.53814691
79Chronic sinusitis (HP:0011109)2.52714188
80Aplasia/Hypoplasia of the earlobes (HP:0009906)2.50914753
81Rhinitis (HP:0012384)2.48758340
82Leukopenia (HP:0001882)2.48599108
83Chronic bronchitis (HP:0004469)2.47604393
84Chronic otitis media (HP:0000389)2.45294661
85Microvesicular hepatic steatosis (HP:0001414)2.44320837
86Metabolic alkalosis (HP:0200114)2.41914994
87Abnormality of the renal medulla (HP:0100957)2.41504376
88Rhabdomyosarcoma (HP:0002859)2.41213859
89Osteomyelitis (HP:0002754)2.40269768
90Postaxial hand polydactyly (HP:0001162)2.39478380
91Absent eyebrow (HP:0002223)2.38666825
92Nephronophthisis (HP:0000090)2.37084910
93Aplasia/Hypoplasia of the breasts (HP:0010311)2.37030592
94Chronic diarrhea (HP:0002028)2.36417651
95Hypokalemic alkalosis (HP:0001949)2.34113422
96Decreased testicular size (HP:0008734)2.32933413
97Pancreatic cysts (HP:0001737)2.31643817
98Erectile abnormalities (HP:0100639)2.31604558
99Woolly hair (HP:0002224)2.31383352
100Viral hepatitis (HP:0006562)2.30271851
101Gastrointestinal stroma tumor (HP:0100723)2.27989344
102Deep philtrum (HP:0002002)2.27926463
103Occipital encephalocele (HP:0002085)2.25101028
104Basal cell carcinoma (HP:0002671)2.23301157
105Abnormality of chloride homeostasis (HP:0011422)2.21293955
106Hyperaldosteronism (HP:0000859)2.19874387
107Postaxial foot polydactyly (HP:0001830)2.19687662
108Impulsivity (HP:0100710)2.18579503
109Oculomotor apraxia (HP:0000657)2.17782259
110Testicular atrophy (HP:0000029)2.17429193
111Limb-girdle muscle weakness (HP:0003325)2.14136378
112Degeneration of anterior horn cells (HP:0002398)2.14021605
113Abnormality of the anterior horn cell (HP:0006802)2.14021605
114Abnormality of nail color (HP:0100643)2.13997035
115Multifactorial inheritance (HP:0001426)2.12209503
116Chronic hepatic failure (HP:0100626)2.11807580
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.11173049
118Recurrent lower respiratory tract infections (HP:0002783)2.08490556
119Aplasia/Hypoplasia of the uvula (HP:0010293)2.07522973
120Abnormality of sodium homeostasis (HP:0010931)2.07425218
121Bronchiectasis (HP:0002110)2.05945352
122Abnormal tarsal ossification (HP:0008369)2.05596676
123Lip pit (HP:0100267)2.04479466
124Birth length less than 3rd percentile (HP:0003561)2.02146031
125Absence seizures (HP:0002121)2.01469754
126Short nail (HP:0001799)1.99754971
127Bradycardia (HP:0001662)1.99202160
128Sparse eyelashes (HP:0000653)1.97731289
129Scrotal hypoplasia (HP:0000046)1.97474611
130Vasculitis (HP:0002633)1.96988160
131Abnormality of the prostate (HP:0008775)1.96719125
132Sex reversal (HP:0012245)1.95818953
133Abnormal sex determination (HP:0012244)1.95818953
134Restrictive lung disease (HP:0002091)1.95425117
135Nasal polyposis (HP:0100582)1.94549610
136B lymphocytopenia (HP:0010976)1.93678250
137Vertebral arch anomaly (HP:0008438)1.93199432
138Neoplasm of striated muscle (HP:0009728)1.92866056
139Mediastinal lymphadenopathy (HP:0100721)1.92469529
14011 pairs of ribs (HP:0000878)1.90326896
141Cafe-au-lait spot (HP:0000957)1.89143746
142Tubulointerstitial nephritis (HP:0001970)1.88970956
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88319275
144Preaxial hand polydactyly (HP:0001177)1.87837274
145Ependymoma (HP:0002888)1.87133950
146Recurrent otitis media (HP:0000403)1.86857769
147Dehydration (HP:0001944)1.86805185
148Renal salt wasting (HP:0000127)1.86632737
149Syncope (HP:0001279)1.86330950
150Atelectasis (HP:0100750)1.85850098
151Absent thumb (HP:0009777)1.85671850
152Gout (HP:0001997)1.85671544
153Hyperlipoproteinemia (HP:0010980)1.85425084
154Male pseudohermaphroditism (HP:0000037)1.85089266
155Recurrent pneumonia (HP:0006532)1.85008392
156Myelodysplasia (HP:0002863)1.84184053
157Tinnitus (HP:0000360)1.83553058
158Progressive muscle weakness (HP:0003323)1.82705766
159Cystic liver disease (HP:0006706)1.82375163
160Abnormal cartilage morphology (HP:0002763)1.82139566
161Tubulointerstitial abnormality (HP:0001969)1.81858261
162Hyperglycinemia (HP:0002154)1.81298732
163Tubulointerstitial fibrosis (HP:0005576)1.81200213
164Abnormal foot bone ossification (HP:0010675)1.80829331
165Aplasia/Hypoplasia of the lens (HP:0008063)1.80594114
166Constricted visual fields (HP:0001133)1.79746317
167Dialeptic seizures (HP:0011146)1.78759857
168Meckel diverticulum (HP:0002245)1.78490256
169Adrenal hypoplasia (HP:0000835)1.78202050
170Concave nail (HP:0001598)1.78118326
171Hyponatremia (HP:0002902)1.77166781
172Brushfield spots (HP:0001088)1.77115301
173Abnormality of male internal genitalia (HP:0000022)1.77099120
174Asthma (HP:0002099)1.76028978
175Intellectual disability, moderate (HP:0002342)1.75291043
176Focal seizures (HP:0007359)1.75283192
177Elevated hepatic transaminases (HP:0002910)1.73701735
178Cutis marmorata (HP:0000965)1.73496498
179Abnormality of the ileum (HP:0001549)1.72815492
180External ear malformation (HP:0008572)1.72194616
181External ophthalmoplegia (HP:0000544)1.72166789
182Glioma (HP:0009733)1.70278088
183Septate vagina (HP:0001153)1.70145614
184Facial hemangioma (HP:0000329)1.69281136
185Duodenal stenosis (HP:0100867)1.69135806
186Small intestinal stenosis (HP:0012848)1.69135806
187Abnormality of the carotid arteries (HP:0005344)1.68850933
188Sepsis (HP:0100806)1.67109869
189Dicarboxylic aciduria (HP:0003215)1.65810059
190Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65810059
191Sloping forehead (HP:0000340)1.64632851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB38.49775448
2PLK46.97231983
3BMPR25.92255418
4ERN15.45579450
5MST43.68221831
6ARAF2.74206030
7BLK2.72493256
8SMG12.12584343
9RIPK12.10974454
10SCYL22.06243075
11EIF2AK32.05813090
12PLK22.02533738
13CDK121.96729380
14STK161.94132990
15JAK31.89286058
16TRIB31.83438055
17MAPK151.77021823
18SIK21.73324149
19SRPK11.67752809
20EIF2AK11.65999407
21TLK11.63329800
22MAPKAPK31.56971393
23BRAF1.52685218
24BTK1.52232525
25ITK1.51326231
26DAPK21.50016627
27CSNK1A1L1.48391722
28PIM21.43561546
29STK391.42454599
30INSRR1.40696939
31WEE11.39963902
32SIK31.37837072
33AKT31.37018473
34CDK41.36596256
35MAP3K91.35134947
36EEF2K1.33270441
37CSNK1G31.31087563
38DYRK31.28364779
39CSNK1G21.26542384
40TESK21.25735409
41MAPK111.14045884
42LRRK21.12196064
43PASK1.11969862
44PRPF4B1.11910397
45TNK21.10374000
46NEK11.08695569
47NUAK11.08569695
48TAF11.06907056
49IRAK31.06872326
50NME21.05692092
51CDK191.05131372
52MAP2K31.04719591
53ATR1.03901250
54CSNK1G11.03875516
55PLK30.97816258
56STK240.97381305
57RIPK40.97212092
58DYRK20.94835974
59MAP3K60.93734727
60TEC0.91834621
61EPHA20.90968453
62GRK10.86598258
63TTK0.81924172
64PIK3CG0.81817116
65MAP3K80.81158859
66MAPK130.80634257
67MAP3K130.79749527
68BRSK20.79682457
69BUB10.78846599
70IRAK40.77585027
71NEK20.77368749
72LYN0.77065514
73PHKG20.72928700
74PHKG10.72928700
75MAP2K70.72297627
76GRK60.72176089
77STK38L0.72131007
78NTRK20.71793343
79ACVR1B0.71541360
80PBK0.70978781
81SIK10.70644185
82PRKCI0.70249623
83AURKA0.68581765
84CDK70.67740009
85CAMK1D0.66874354
86PLK10.66367898
87TGFBR20.65633826
88TYK20.63538501
89RPS6KA40.63005566
90CAMK2B0.62760119
91STK100.61170671
92MAP3K40.60741439
93MUSK0.60208300
94BRD40.58112582
95OXSR10.58102411
96RPS6KB10.56345243
97VRK20.56158609
98CDK80.56018808
99IRAK20.55446332
100EIF2AK20.55012573
101TSSK60.54777272
102CAMK2D0.51794664
103CAMK1G0.51014683
104CDK60.50809306
105DYRK1B0.50229313
106MAP4K10.49894739
107FGFR40.48625414
108DYRK1A0.48130940
109ZAK0.46492254
110CSF1R0.45973562
111CAMK2G0.44629494
112PNCK0.43465250
113TBK10.43264386
114MAPKAPK20.43185423
115DAPK10.41580269
116VRK10.41147643
117IKBKB0.40775446
118ATM0.39946796
119RPS6KA50.38789634
120CDK20.38467525
121FER0.38132721
122NEK90.35593029
123MAP3K30.34312206
124PDK10.33819854
125PKN20.33215411
126SGK2230.33173856
127SGK4940.33173856
128MAPK120.32916075
129AURKB0.31748698
130MAP3K100.31744068
131RPS6KB20.31673234
132CDK30.30134039
133CCNB10.29533713
134CASK0.29483817
135PRKCG0.29098707
136RPS6KA20.28082278
137CHEK20.27867538
138CDC70.27426659
139MAP2K60.26113635
140LMTK20.25241719
141SGK20.25060745
142AKT20.23797847
143IKBKE0.23371822
144STK40.22118269
145MAP2K40.20487857
146MAP3K140.20367806
147MKNK10.19680380
148HIPK20.18963336
149SYK0.17509947
150MINK10.17427666
151MST1R0.17323470
152MAP2K20.17002388
153CSNK2A10.16654344
154PRKCQ0.15371419
155PRKCE0.15260937
156CHEK10.13788563
157PRKCZ0.13532019
158MAPK90.13390760

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047408.15675674
2Phototransduction_Homo sapiens_hsa047444.00604546
3RNA polymerase_Homo sapiens_hsa030202.99918505
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.19206574
5Proteasome_Homo sapiens_hsa030502.11389009
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01881767
7Asthma_Homo sapiens_hsa053101.83880333
8Hepatitis C_Homo sapiens_hsa051601.82843500
9Taste transduction_Homo sapiens_hsa047421.77353014
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73219148
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68392003
12Base excision repair_Homo sapiens_hsa034101.67463619
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62916426
14Collecting duct acid secretion_Homo sapiens_hsa049661.53013695
15Allograft rejection_Homo sapiens_hsa053301.51822337
16Notch signaling pathway_Homo sapiens_hsa043301.46575752
17Alcoholism_Homo sapiens_hsa050341.46018847
18Spliceosome_Homo sapiens_hsa030401.43584406
19One carbon pool by folate_Homo sapiens_hsa006701.39751687
20DNA replication_Homo sapiens_hsa030301.39191474
21Regulation of autophagy_Homo sapiens_hsa041401.38713136
22Purine metabolism_Homo sapiens_hsa002301.38610441
23Folate biosynthesis_Homo sapiens_hsa007901.38097218
24Autoimmune thyroid disease_Homo sapiens_hsa053201.32673322
25mRNA surveillance pathway_Homo sapiens_hsa030151.31801235
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27591529
27Epstein-Barr virus infection_Homo sapiens_hsa051691.21744706
28Influenza A_Homo sapiens_hsa051641.21193430
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.19607644
30Serotonergic synapse_Homo sapiens_hsa047261.18501799
31B cell receptor signaling pathway_Homo sapiens_hsa046621.16395199
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13983489
33Pyrimidine metabolism_Homo sapiens_hsa002401.13432677
34Endometrial cancer_Homo sapiens_hsa052131.13382535
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09086304
36Basal transcription factors_Homo sapiens_hsa030221.08952230
37Dopaminergic synapse_Homo sapiens_hsa047281.07870687
38Vitamin digestion and absorption_Homo sapiens_hsa049771.06948104
39Adherens junction_Homo sapiens_hsa045201.06918792
40FoxO signaling pathway_Homo sapiens_hsa040681.04928092
41Morphine addiction_Homo sapiens_hsa050321.04753496
42Histidine metabolism_Homo sapiens_hsa003401.04202579
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04168927
44Type I diabetes mellitus_Homo sapiens_hsa049401.03492949
45Pyruvate metabolism_Homo sapiens_hsa006201.01900556
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.01278315
47Antigen processing and presentation_Homo sapiens_hsa046121.01009621
48Cholinergic synapse_Homo sapiens_hsa047251.00752104
49Graft-versus-host disease_Homo sapiens_hsa053320.99883781
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97096891
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96231496
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93327491
53Tight junction_Homo sapiens_hsa045300.93323959
54Chronic myeloid leukemia_Homo sapiens_hsa052200.92925022
55Non-homologous end-joining_Homo sapiens_hsa034500.92801531
56Vitamin B6 metabolism_Homo sapiens_hsa007500.92685904
57Fructose and mannose metabolism_Homo sapiens_hsa000510.91010434
58beta-Alanine metabolism_Homo sapiens_hsa004100.91003509
59Colorectal cancer_Homo sapiens_hsa052100.90148324
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89875356
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89326042
62Insulin secretion_Homo sapiens_hsa049110.89199628
63Mismatch repair_Homo sapiens_hsa034300.89126559
64Fanconi anemia pathway_Homo sapiens_hsa034600.87969815
65Circadian entrainment_Homo sapiens_hsa047130.87855203
66Hematopoietic cell lineage_Homo sapiens_hsa046400.86547539
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85784348
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85527598
69Sulfur relay system_Homo sapiens_hsa041220.85174673
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84368092
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83138585
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81524406
73Measles_Homo sapiens_hsa051620.81420098
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81204345
75Prostate cancer_Homo sapiens_hsa052150.78756992
76Non-small cell lung cancer_Homo sapiens_hsa052230.78485192
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76591712
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76213477
79RNA transport_Homo sapiens_hsa030130.73621919
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.73221585
81Inositol phosphate metabolism_Homo sapiens_hsa005620.72635088
82Hepatitis B_Homo sapiens_hsa051610.72240227
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70760980
84Primary immunodeficiency_Homo sapiens_hsa053400.69490771
85Biosynthesis of amino acids_Homo sapiens_hsa012300.68214234
86Vibrio cholerae infection_Homo sapiens_hsa051100.67788725
87HTLV-I infection_Homo sapiens_hsa051660.66111703
88Huntingtons disease_Homo sapiens_hsa050160.64669450
89RNA degradation_Homo sapiens_hsa030180.63228193
90Apoptosis_Homo sapiens_hsa042100.63171100
91Systemic lupus erythematosus_Homo sapiens_hsa053220.62621661
92Sulfur metabolism_Homo sapiens_hsa009200.62566586
93Pancreatic cancer_Homo sapiens_hsa052120.62388221
94Homologous recombination_Homo sapiens_hsa034400.62241541
95Propanoate metabolism_Homo sapiens_hsa006400.62166216
96Synaptic vesicle cycle_Homo sapiens_hsa047210.61969498
97Cell cycle_Homo sapiens_hsa041100.60999645
98Leishmaniasis_Homo sapiens_hsa051400.60957557
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60425718
100Renin-angiotensin system_Homo sapiens_hsa046140.59041215
101Nucleotide excision repair_Homo sapiens_hsa034200.58822733
102Sphingolipid metabolism_Homo sapiens_hsa006000.58650934
103ABC transporters_Homo sapiens_hsa020100.57761429
104Chemokine signaling pathway_Homo sapiens_hsa040620.56213928
105Toxoplasmosis_Homo sapiens_hsa051450.56079590
106p53 signaling pathway_Homo sapiens_hsa041150.55158951
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.54064986
108GABAergic synapse_Homo sapiens_hsa047270.53863251
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53815973
110Viral carcinogenesis_Homo sapiens_hsa052030.51505350
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51476933
112Pentose phosphate pathway_Homo sapiens_hsa000300.50804730
113N-Glycan biosynthesis_Homo sapiens_hsa005100.50584711
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49555012
115Ras signaling pathway_Homo sapiens_hsa040140.48438927
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.48190445
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47435634
118Acute myeloid leukemia_Homo sapiens_hsa052210.46742243
119Ribosome_Homo sapiens_hsa030100.46395547
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46136306
121Herpes simplex infection_Homo sapiens_hsa051680.45560165
122Phenylalanine metabolism_Homo sapiens_hsa003600.45469346
123Thyroid cancer_Homo sapiens_hsa052160.44422957
124Arachidonic acid metabolism_Homo sapiens_hsa005900.44403257
125Peroxisome_Homo sapiens_hsa041460.44006782
126Fat digestion and absorption_Homo sapiens_hsa049750.43638519
127Bladder cancer_Homo sapiens_hsa052190.43458819
128Arginine biosynthesis_Homo sapiens_hsa002200.43410902
129Oocyte meiosis_Homo sapiens_hsa041140.43137990
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42914725
131Lysine degradation_Homo sapiens_hsa003100.42458269
132Carbon metabolism_Homo sapiens_hsa012000.40879097
133Tuberculosis_Homo sapiens_hsa051520.40697674
134Glutamatergic synapse_Homo sapiens_hsa047240.40113670
135GnRH signaling pathway_Homo sapiens_hsa049120.40110668
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40066817
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38876443
138Caffeine metabolism_Homo sapiens_hsa002320.38757927
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.38490640
140Chemical carcinogenesis_Homo sapiens_hsa052040.38104369
141Glutathione metabolism_Homo sapiens_hsa004800.38089889
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.37478061
143Other glycan degradation_Homo sapiens_hsa005110.35532629
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35470171
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.35403450
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35275151
147Prolactin signaling pathway_Homo sapiens_hsa049170.34156910
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33484840
149Steroid biosynthesis_Homo sapiens_hsa001000.31548953
150Small cell lung cancer_Homo sapiens_hsa052220.30156036
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30152264
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29822341
153Viral myocarditis_Homo sapiens_hsa054160.28585648

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