ELMO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.56133714
2locomotory exploration behavior (GO:0035641)5.55259441
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36069125
4synaptic vesicle exocytosis (GO:0016079)4.99066306
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.98392191
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.95474558
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81307902
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80489586
9glutamate secretion (GO:0014047)4.68735901
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.59642922
11vocalization behavior (GO:0071625)4.57032693
12regulation of synaptic vesicle exocytosis (GO:2000300)4.45695078
13regulation of glutamate receptor signaling pathway (GO:1900449)4.40037961
14neuronal action potential propagation (GO:0019227)4.39760559
15cellular potassium ion homeostasis (GO:0030007)4.31525128
16sodium ion export (GO:0071436)4.26895420
17protein localization to synapse (GO:0035418)4.24205600
18glutamate receptor signaling pathway (GO:0007215)4.20431370
19regulation of synapse structural plasticity (GO:0051823)4.17987359
20synaptic transmission, glutamatergic (GO:0035249)4.09026579
21exploration behavior (GO:0035640)4.08341869
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05466360
23regulation of neuronal synaptic plasticity (GO:0048168)3.99450140
24regulation of synaptic vesicle transport (GO:1902803)3.94637095
25negative regulation of cell killing (GO:0031342)3.90951646
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.90951646
27layer formation in cerebral cortex (GO:0021819)3.82792838
28neurotransmitter secretion (GO:0007269)3.77876290
29neurotransmitter-gated ion channel clustering (GO:0072578)3.75774227
30positive regulation of synapse maturation (GO:0090129)3.75364711
31pyrimidine nucleobase catabolic process (GO:0006208)3.74504368
32neuron-neuron synaptic transmission (GO:0007270)3.70462561
33long-term memory (GO:0007616)3.67472838
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.62242514
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55373680
36establishment of nucleus localization (GO:0040023)3.54348500
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54068430
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53273851
39neuron cell-cell adhesion (GO:0007158)3.52701459
40L-amino acid import (GO:0043092)3.49693915
41gamma-aminobutyric acid transport (GO:0015812)3.49568497
42proline transport (GO:0015824)3.48975831
43cell communication by electrical coupling (GO:0010644)3.43803761
44regulation of activation of Janus kinase activity (GO:0010533)3.43666395
45dendritic spine morphogenesis (GO:0060997)3.41447659
46regulation of memory T cell differentiation (GO:0043380)3.41293032
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40044307
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39905633
49regulation of synaptic plasticity (GO:0048167)3.39803525
50cerebellar Purkinje cell differentiation (GO:0021702)3.38754622
51long-term synaptic potentiation (GO:0060291)3.37843493
52positive regulation of membrane potential (GO:0045838)3.37729397
53neuromuscular process controlling balance (GO:0050885)3.35208082
54synaptic vesicle endocytosis (GO:0048488)3.34571528
55regulation of postsynaptic membrane potential (GO:0060078)3.33051571
56positive regulation of gamma-delta T cell activation (GO:0046645)3.28689086
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.27393098
58dendrite morphogenesis (GO:0048813)3.24932142
59cerebellar granule cell differentiation (GO:0021707)3.21919185
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18463007
61negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.17763349
62regulation of neurotransmitter secretion (GO:0046928)3.17653615
63cellular response to interleukin-15 (GO:0071350)3.16032344
64regulation of vesicle fusion (GO:0031338)3.15489448
65alanine transport (GO:0032328)3.10895052
66regulation of dendritic spine morphogenesis (GO:0061001)3.10504907
67transmission of nerve impulse (GO:0019226)3.10469209
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09752232
69axonal fasciculation (GO:0007413)3.09325988
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.09018284
71neuron recognition (GO:0008038)3.06749418
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06177673
73activation of protein kinase A activity (GO:0034199)3.02983981
74neurotransmitter transport (GO:0006836)3.01718948
75potassium ion import (GO:0010107)3.01512186
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00953514
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00501827
78innervation (GO:0060384)2.97865008
79regulation of chronic inflammatory response (GO:0002676)2.97560040
80auditory behavior (GO:0031223)2.94809663
81postsynaptic membrane organization (GO:0001941)2.92576670
82regulation of neurotransmitter transport (GO:0051588)2.92479218
83nucleobase catabolic process (GO:0046113)2.91648957
84activated T cell proliferation (GO:0050798)2.91606656
85negative regulation of interleukin-10 production (GO:0032693)2.91167783
86amino acid import (GO:0043090)2.90985734
87response to interleukin-15 (GO:0070672)2.90870735
88membrane depolarization (GO:0051899)2.90781306
89glycine transport (GO:0015816)2.90604636
90response to auditory stimulus (GO:0010996)2.90323561
91positive regulation of humoral immune response (GO:0002922)2.89686525
92response to muramyl dipeptide (GO:0032495)2.89056326
93positive regulation of defense response to virus by host (GO:0002230)2.88120371
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87667386
95membrane depolarization during action potential (GO:0086010)2.86438461
96positive regulation of neurotransmitter secretion (GO:0001956)2.85796869
97regulation of voltage-gated calcium channel activity (GO:1901385)2.84903543
98regulation of ARF protein signal transduction (GO:0032012)2.83625484
99positive regulation of dendritic spine development (GO:0060999)2.82557535
100response to histamine (GO:0034776)2.82417091
101positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81605146
102cellular sodium ion homeostasis (GO:0006883)2.81110856
103regulation of synapse maturation (GO:0090128)2.81001178
104response to pheromone (GO:0019236)2.80494594
105C4-dicarboxylate transport (GO:0015740)2.80440121
106regulation of neurotransmitter levels (GO:0001505)2.79417288
107regulation of synaptic transmission (GO:0050804)2.79068322
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78586119
109long term synaptic depression (GO:0060292)2.77824444
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.77704116
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.76548137
112regulation of dendritic spine development (GO:0060998)2.76227392
113positive regulation of synaptic transmission (GO:0050806)2.75047965
114positive regulation of T cell cytokine production (GO:0002726)2.74849893
115T cell migration (GO:0072678)2.74548900
116learning (GO:0007612)2.73353105
117behavioral fear response (GO:0001662)2.69335680
118behavioral defense response (GO:0002209)2.69335680
119synapse assembly (GO:0007416)2.68053400
120negative regulation of interleukin-12 production (GO:0032695)2.66129679
121cellular response to type I interferon (GO:0071357)2.52712144
122type I interferon signaling pathway (GO:0060337)2.52712144
123granulocyte activation (GO:0036230)2.52669223
124positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.50668198
125lymphocyte chemotaxis (GO:0048247)2.47987650
126positive regulation of interleukin-17 production (GO:0032740)2.47021925
127glycosphingolipid biosynthetic process (GO:0006688)2.46770509
128regulation of gamma-delta T cell activation (GO:0046643)2.45982847
129response to type I interferon (GO:0034340)2.44725201
130neutrophil activation (GO:0042119)2.37134080
131positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.36866606
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34562285
133regulation of defense response to virus by host (GO:0050691)2.34471201
134signal complex assembly (GO:0007172)2.34035352
135regulation of regulatory T cell differentiation (GO:0045589)2.34030603
136negative regulation of T cell mediated immunity (GO:0002710)2.33728476
137regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.32714506
138regulation of vitamin D biosynthetic process (GO:0060556)2.32678703
139regulation of T cell mediated cytotoxicity (GO:0001914)2.29567474
140regulation of natural killer cell mediated immunity (GO:0002715)2.29464063
141regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.29464063
142positive regulation of type 2 immune response (GO:0002830)2.29031051
143negative T cell selection (GO:0043383)2.28130240
144negative thymic T cell selection (GO:0045060)2.28105703
145negative regulation of cytokine production involved in immune response (GO:0002719)2.27408170
146regulation of T-helper cell differentiation (GO:0045622)2.27182457
147regulation of immunoglobulin secretion (GO:0051023)2.26978078
148regulation of chemokine-mediated signaling pathway (GO:0070099)2.26755968
149acidic amino acid transport (GO:0015800)2.24881273
150leukocyte aggregation (GO:0070486)2.23140105
151regulation of interleukin-17 production (GO:0032660)2.22365164
152regulation of B cell receptor signaling pathway (GO:0050855)2.20742889
153regulation of leukocyte mediated cytotoxicity (GO:0001910)2.18496692
154negative regulation of oligodendrocyte differentiation (GO:0048715)2.17056328
155nerve growth factor signaling pathway (GO:0038180)2.16252150
156negative regulation of lymphocyte mediated immunity (GO:0002707)2.14651406
157positive regulation of toll-like receptor signaling pathway (GO:0034123)2.13842174
158regulation of interleukin-12 production (GO:0032655)2.13678808
159positive regulation of T-helper cell differentiation (GO:0045624)2.12601230
160regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.12473953
161macroautophagy (GO:0016236)2.11098750
162regulation of gamma-delta T cell differentiation (GO:0045586)2.10924295
163regulation of T cell tolerance induction (GO:0002664)2.09357053
164negative regulation of leukocyte mediated immunity (GO:0002704)2.09217921
165interleukin-6-mediated signaling pathway (GO:0070102)2.08540459
166regulation of cell killing (GO:0031341)2.08286015
167positive regulation of osteoclast differentiation (GO:0045672)2.07713325
168regulation of T cell cytokine production (GO:0002724)2.07655125
169positive regulation of interleukin-12 production (GO:0032735)2.07560018
170regulation of lymphocyte chemotaxis (GO:1901623)2.06887709
171N-glycan processing (GO:0006491)2.06147748
172myeloid dendritic cell differentiation (GO:0043011)2.05488108
173presynaptic membrane assembly (GO:0097105)2.04944528
174positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.03885976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48086346
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.29422267
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26341189
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25819580
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09048686
6IKZF1_21737484_ChIP-ChIP_HCT116_Human3.03804761
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.03606524
8DROSHA_22980978_ChIP-Seq_HELA_Human2.96686682
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95191219
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95191219
11GBX2_23144817_ChIP-Seq_PC3_Human2.94818386
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.83362841
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82927703
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.78991324
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76767189
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.72350214
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70944216
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.67175013
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.65542289
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56723298
21REST_21632747_ChIP-Seq_MESCs_Mouse2.52512050
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.50036489
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.48185826
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45633396
25RUNX_20019798_ChIP-Seq_JUKART_Human2.43054097
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39444043
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.39202041
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38487557
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.37278832
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34745114
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25820966
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.12138001
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92930199
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92098884
35* IRF8_27001747_Chip-Seq_BMDM_Mouse1.84320868
36AR_21572438_ChIP-Seq_LNCaP_Human1.83333882
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82030142
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71854052
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71291236
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70677998
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.63134114
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61565621
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59229883
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58835659
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58348691
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56049291
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.53763795
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53475208
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53428549
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52529674
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52192712
52KDM2B_26808549_Chip-Seq_K562_Human1.47179729
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47160411
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.45075533
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44791485
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44041414
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41111989
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36067984
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36034394
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35762114
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34714686
62* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33580256
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33546260
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32769783
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32524201
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31954161
67SPI1_23127762_ChIP-Seq_K562_Human1.30481471
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28900402
69SMAD4_21799915_ChIP-Seq_A2780_Human1.27078724
70* GATA3_27048872_Chip-Seq_THYMUS_Human1.26688053
71VDR_24787735_ChIP-Seq_THP-1_Human1.26634289
72* AR_19668381_ChIP-Seq_PC3_Human1.25452849
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24685542
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24042850
75TP53_16413492_ChIP-PET_HCT116_Human1.23417532
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.22891498
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21789912
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.19910566
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19867080
80IGF1R_20145208_ChIP-Seq_DFB_Human1.19272266
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17931853
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17678675
83* MYB_26560356_Chip-Seq_TH2_Human1.15459198
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11544885
85GATA3_26560356_Chip-Seq_TH2_Human1.11010789
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10437037
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09418339
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08737565
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08674244
90* AR_25329375_ChIP-Seq_VCAP_Human1.08553629
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08546321
92* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08199902
93UTX_26944678_Chip-Seq_JUKART_Human1.07269525
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.07038610
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06976712
96RXR_22108803_ChIP-Seq_LS180_Human1.04881707
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04559312
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.02560255
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02522876
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02496402
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01371085
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00802942
103WT1_19549856_ChIP-ChIP_CCG9911_Human0.99588994
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99221446
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97858882
106STAT3_23295773_ChIP-Seq_U87_Human0.97636988
107* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97005503
108P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96802633
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.96594290
110* P300_19829295_ChIP-Seq_ESCs_Human0.95973318
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95948024
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.95939605
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95844913
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.95701207
115ZNF274_21170338_ChIP-Seq_K562_Hela0.95555903
116LXR_22292898_ChIP-Seq_THP-1_Human0.95499350
117ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94641633
118KDM2B_26808549_Chip-Seq_DND41_Human0.94176732
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93798930
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92949480
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.90648217
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.90167570
123TAF15_26573619_Chip-Seq_HEK293_Human0.89721587
124AHR_22903824_ChIP-Seq_MCF-7_Human0.89590294
125IRF1_19129219_ChIP-ChIP_H3396_Human0.89295255
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89238661
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.88242939
128* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88052226
129* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87582045
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86983626
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.86856350
132SMRT_27268052_Chip-Seq_Bcells_Human0.86744859
133TCF4_23295773_ChIP-Seq_U87_Human0.86553690
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.86475854
135TP53_18474530_ChIP-ChIP_U2OS_Human0.86162953
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84326040
137NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83615248
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83550100
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83252900
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83057258
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82311846
142* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82171003
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.82014826
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81575848
145SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80463860
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79825834
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79298815
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76355445
149NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74229400
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74201148
151PU1_27457419_Chip-Seq_LIVER_Mouse0.73898580
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.73678219
153* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72806449
154GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71654822
155MAF_26560356_Chip-Seq_TH1_Human0.71277393
156LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68964813
157MAF_26560356_Chip-Seq_TH2_Human0.68660449
158SPI1_23547873_ChIP-Seq_NB4_Human0.67815491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.82260298
2MP0003880_abnormal_central_pattern4.30955528
3MP0003635_abnormal_synaptic_transmissio4.11659560
4MP0003724_increased_susceptibility_to3.76130437
5MP0009745_abnormal_behavioral_response3.20834269
6MP0002063_abnormal_learning/memory/cond3.17310431
7MP0002064_seizures3.12043253
8MP0004270_analgesia3.09887671
9MP0009046_muscle_twitch3.04933259
10MP0001968_abnormal_touch/_nociception2.96544518
11MP0005671_abnormal_response_to2.86349529
12MP0003436_decreased_susceptibility_to2.79699785
13MP0006082_CNS_inflammation2.68136780
14MP0002572_abnormal_emotion/affect_behav2.61519669
15MP0002736_abnormal_nociception_after2.51622021
16MP0001486_abnormal_startle_reflex2.50186543
17MP0002272_abnormal_nervous_system2.45614304
18MP0005423_abnormal_somatic_nervous2.43455276
19MP0008569_lethality_at_weaning2.33928086
20MP0009785_altered_susceptibility_to2.30830071
21MP0002734_abnormal_mechanical_nocicepti2.16834970
22MP0001440_abnormal_grooming_behavior2.15214463
23MP0004858_abnormal_nervous_system2.14462310
24MP0005000_abnormal_immune_tolerance2.12844827
25MP0002735_abnormal_chemical_nociception2.10954373
26MP0009780_abnormal_chondrocyte_physiolo1.98670827
27MP0001501_abnormal_sleep_pattern1.92379260
28MP0008260_abnormal_autophagy1.90557214
29MP0002733_abnormal_thermal_nociception1.89832068
30MP0002067_abnormal_sensory_capabilities1.88403266
31MP0003329_amyloid_beta_deposits1.87023953
32MP0001970_abnormal_pain_threshold1.84257827
33MP0001790_abnormal_immune_system1.74253242
34MP0005387_immune_system_phenotype1.74253242
35MP0004811_abnormal_neuron_physiology1.73698633
36MP0002723_abnormal_immune_serum1.67815406
37MP0002557_abnormal_social/conspecific_i1.66595981
38MP0000778_abnormal_nervous_system1.65927565
39MP0002148_abnormal_hypersensitivity_rea1.63269161
40MP0002184_abnormal_innervation1.62752185
41MP0002419_abnormal_innate_immunity1.62221213
42MP0001800_abnormal_humoral_immune1.62145962
43MP0001533_abnormal_skeleton_physiology1.59906576
44MP0003690_abnormal_glial_cell1.58468442
45MP0005025_abnormal_response_to1.55391197
46MP0004885_abnormal_endolymph1.55307375
47MP0001986_abnormal_taste_sensitivity1.55089743
48MP0003300_gastrointestinal_ulcer1.50078216
49MP0001835_abnormal_antigen_presentation1.49190733
50MP0000955_abnormal_spinal_cord1.48474173
51MP0003879_abnormal_hair_cell1.48158651
52MP0002822_catalepsy1.42688840
53MP0002420_abnormal_adaptive_immunity1.42081838
54MP0003633_abnormal_nervous_system1.41743997
55MP0004924_abnormal_behavior1.41612204
56MP0005386_behavior/neurological_phenoty1.41612204
57MP0001819_abnormal_immune_cell1.41312300
58MP0002882_abnormal_neuron_morphology1.40537030
59MP0005646_abnormal_pituitary_gland1.35628028
60MP0005623_abnormal_meninges_morphology1.34404418
61MP0002452_abnormal_antigen_presenting1.33786206
62MP0002066_abnormal_motor_capabilities/c1.33673166
63MP0005058_abnormal_lysosome_morphology1.33628771
64MP0002909_abnormal_adrenal_gland1.33193729
65MP0003075_altered_response_to1.28058793
66MP0000685_abnormal_immune_system1.25482122
67MP0001502_abnormal_circadian_rhythm1.24445838
68MP0003634_abnormal_glial_cell1.19738477
69MP0003172_abnormal_lysosome_physiology1.19362169
70MP0002405_respiratory_system_inflammati1.18767146
71MP0003631_nervous_system_phenotype1.18647567
72MP0000751_myopathy1.16840555
73MP0004142_abnormal_muscle_tone1.15681755
74MP0003195_calcinosis1.12947029
75MP0002152_abnormal_brain_morphology1.11424817
76MP0005310_abnormal_salivary_gland1.10174667
77MP0003763_abnormal_thymus_physiology1.10050378
78MP0000920_abnormal_myelination1.09258782
79MP0000569_abnormal_digit_pigmentation1.08459146
80MP0003122_maternal_imprinting1.07725667
81MP0000465_gastrointestinal_hemorrhage1.06541230
82MP0000015_abnormal_ear_pigmentation1.05269201
83MP0003191_abnormal_cellular_cholesterol1.05101555
84MP0003183_abnormal_peptide_metabolism1.04166200
85MP0001845_abnormal_inflammatory_respons1.03284350
86MP0001905_abnormal_dopamine_level1.02793209
87MP0008961_abnormal_basal_metabolism1.02484239
88MP0002653_abnormal_ependyma_morphology1.01286841
89MP0004947_skin_inflammation1.01127180
90MP0004510_myositis1.00808848
91MP0002332_abnormal_exercise_endurance0.98155256
92MP0003787_abnormal_imprinting0.97733065
93MP0000716_abnormal_immune_system0.94905700
94MP0008874_decreased_physiological_sensi0.94481097
95MP0004233_abnormal_muscle_weight0.93922449
96MP0006276_abnormal_autonomic_nervous0.93827942
97MP0001984_abnormal_olfaction0.92593509
98MP0003632_abnormal_nervous_system0.91809866
99MP0000604_amyloidosis0.91150660
100MP0002933_joint_inflammation0.90223361
101MP0002398_abnormal_bone_marrow0.90141557
102MP0010155_abnormal_intestine_physiology0.87173133
103MP0005645_abnormal_hypothalamus_physiol0.86887513
104MP0003866_abnormal_defecation0.86404175
105MP0000013_abnormal_adipose_tissue0.86061300
106MP0009764_decreased_sensitivity_to0.84806793
107MP0002229_neurodegeneration0.83417901
108MP0006054_spinal_hemorrhage0.83156508
109MP0005394_taste/olfaction_phenotype0.83006633
110MP0005499_abnormal_olfactory_system0.83006633
111MP0009840_abnormal_foam_cell0.81127836
112MP0002090_abnormal_vision0.79973060
113MP0008469_abnormal_protein_level0.78912556
114MP0004742_abnormal_vestibular_system0.78281596
115MP0001299_abnormal_eye_distance/0.77395158
116MP0005464_abnormal_platelet_physiology0.77172640
117MP0005167_abnormal_blood-brain_barrier0.76354101
118MP0001963_abnormal_hearing_physiology0.76306970
119MP0005551_abnormal_eye_electrophysiolog0.75644294
120MP0002069_abnormal_eating/drinking_beha0.74461008
121MP0001177_atelectasis0.74077290
122MP0004145_abnormal_muscle_electrophysio0.73881276
123MP0002089_abnormal_postnatal_growth/wei0.72993529
124MP0003279_aneurysm0.72893292
125MP0000689_abnormal_spleen_morphology0.72852394
126MP0003045_fibrosis0.71814859
127MP0004085_abnormal_heartbeat0.69660996
128MP0001188_hyperpigmentation0.69585422
129MP0003283_abnormal_digestive_organ0.68586143
130MP0005595_abnormal_vascular_smooth0.68142634
131MP0002752_abnormal_somatic_nervous0.67679538
132MP0003303_peritoneal_inflammation0.66859953
133MP0003091_abnormal_cell_migration0.63700154
134MP0004484_altered_response_of0.63591099
135MP0003137_abnormal_impulse_conducting0.63098704
136MP0000534_abnormal_ureter_morphology0.62482969
137MP0001943_abnormal_respiration0.62393972
138MP0003861_abnormal_nervous_system0.58992831
139MP0010769_abnormal_survival0.56727672
140MP0001529_abnormal_vocalization0.56243532
141MP0005409_darkened_coat_color0.54301106
142MP0010768_mortality/aging0.52068434
143MP0001958_emphysema0.51653339
144MP0010770_preweaning_lethality0.51058609
145MP0002082_postnatal_lethality0.51058609
146MP0004215_abnormal_myocardial_fiber0.50217181
147MP0000631_abnormal_neuroendocrine_gland0.50178271

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.16160001
2Myokymia (HP:0002411)5.57604522
3Optic neuritis (HP:0100653)5.15085561
4Retrobulbar optic neuritis (HP:0100654)5.15085561
5Focal seizures (HP:0007359)4.97623188
6Orchitis (HP:0100796)4.59869451
7Epileptic encephalopathy (HP:0200134)4.54601079
8Stomatitis (HP:0010280)4.50456853
9Visual hallucinations (HP:0002367)4.44136594
10Myositis (HP:0100614)4.34100447
11Atonic seizures (HP:0010819)4.12970784
12Progressive cerebellar ataxia (HP:0002073)4.10369099
13Amyotrophic lateral sclerosis (HP:0007354)4.05206848
14Action tremor (HP:0002345)3.98963334
15Hemiplegia (HP:0002301)3.77932618
16Supranuclear gaze palsy (HP:0000605)3.54519691
17Febrile seizures (HP:0002373)3.47576187
18Abnormality of binocular vision (HP:0011514)3.40370184
19Diplopia (HP:0000651)3.40370184
20Absence seizures (HP:0002121)3.39689519
21Dialeptic seizures (HP:0011146)3.21547652
22Keratoconjunctivitis sicca (HP:0001097)3.19148335
23Peripheral hypomyelination (HP:0007182)3.18048694
24Abnormality of liposaccharide metabolism (HP:0010968)3.09596680
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.09596680
26Abnormality of glycolipid metabolism (HP:0010969)3.09596680
27Megalencephaly (HP:0001355)3.08653541
28Eczematoid dermatitis (HP:0000976)3.06166582
29Keratoconjunctivitis (HP:0001096)3.04926298
30Depression (HP:0000716)2.97587214
31Abnormal eating behavior (HP:0100738)2.97288531
32Truncal ataxia (HP:0002078)2.94879598
33Dysdiadochokinesis (HP:0002075)2.90068255
34Generalized tonic-clonic seizures (HP:0002069)2.89426362
35Papilledema (HP:0001085)2.89268442
36Abnormality of macrophages (HP:0004311)2.88504383
37Pointed chin (HP:0000307)2.86134956
38Mutism (HP:0002300)2.84554612
39Ankle clonus (HP:0011448)2.83651204
40Broad-based gait (HP:0002136)2.83076302
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.81331891
42Annular pancreas (HP:0001734)2.80875368
43Hemiparesis (HP:0001269)2.80149662
44Poor eye contact (HP:0000817)2.78340556
45Gaze-evoked nystagmus (HP:0000640)2.75758430
46Impaired smooth pursuit (HP:0007772)2.74462155
47Abnormality of the lower motor neuron (HP:0002366)2.73045889
48Dysmetria (HP:0001310)2.68612698
49Loss of speech (HP:0002371)2.66053178
50Abnormality of eosinophils (HP:0001879)2.64997391
51Increased IgM level (HP:0003496)2.63148690
52Recurrent bacterial skin infections (HP:0005406)2.61800972
53Neurofibrillary tangles (HP:0002185)2.61276481
54T lymphocytopenia (HP:0005403)2.60853710
55Recurrent abscess formation (HP:0002722)2.59639324
56Stereotypic behavior (HP:0000733)2.57327616
57Cerebral inclusion bodies (HP:0100314)2.48182971
58Abnormality of T cell number (HP:0011839)2.47489741
59Narrow nasal bridge (HP:0000446)2.47215136
60Severe combined immunodeficiency (HP:0004430)2.46551280
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.44716169
62Impaired social interactions (HP:0000735)2.39147618
63Abnormal social behavior (HP:0012433)2.39147618
64Postural instability (HP:0002172)2.38199262
65Abnormality of ocular smooth pursuit (HP:0000617)2.36882461
66Spinal canal stenosis (HP:0003416)2.35008691
67Pulmonary infiltrates (HP:0002113)2.34895531
68Impaired vibration sensation in the lower limbs (HP:0002166)2.34758532
69Amblyopia (HP:0000646)2.34666867
70Genetic anticipation (HP:0003743)2.32033928
71Dysostosis multiplex (HP:0000943)2.30697663
72Aplasia involving bones of the extremities (HP:0009825)2.28479230
73Aplasia involving bones of the upper limbs (HP:0009823)2.28479230
74Aplasia of the phalanges of the hand (HP:0009802)2.28479230
75Encephalitis (HP:0002383)2.25929328
76Mediastinal lymphadenopathy (HP:0100721)2.25548902
77Insomnia (HP:0100785)2.20252645
78Leukocytosis (HP:0001974)2.19848207
79Tetraplegia (HP:0002445)2.18788364
80Neuronal loss in central nervous system (HP:0002529)2.17999956
81Eosinophilia (HP:0001880)2.17968912
82Anxiety (HP:0000739)2.16273310
83Intention tremor (HP:0002080)2.16173529
84Urinary bladder sphincter dysfunction (HP:0002839)2.15139909
85Episodic fever (HP:0001954)2.14257357
86Scanning speech (HP:0002168)2.13705073
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13059691
88Abnormality of polysaccharide metabolism (HP:0011012)2.13059691
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13059691
90Rapidly progressive (HP:0003678)2.11081402
91Apathy (HP:0000741)2.10317455
92Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09946378
93Hypoplasia of the brainstem (HP:0002365)2.09946378
94Memory impairment (HP:0002354)2.08749024
95Spastic gait (HP:0002064)2.07185951
96Shallow orbits (HP:0000586)2.06781214
97Lower limb asymmetry (HP:0100559)2.06141050
98Ankyloglossia (HP:0010296)2.03258299
99Hypsarrhythmia (HP:0002521)2.02732133
100Hemoptysis (HP:0002105)2.01749101
101Keratitis (HP:0000491)2.01172940
102Gastrointestinal infarctions (HP:0005244)1.99515159
103Dysmetric saccades (HP:0000641)1.98221327
104Neoplasm of the heart (HP:0100544)1.97079956
105Abnormality of the motor neurons (HP:0002450)1.96257638
106Abnormal neuron morphology (HP:0012757)1.96257638
107Increased cerebral lipofuscin (HP:0011813)1.95741341
108Hypoventilation (HP:0002791)1.95729164
109Urinary urgency (HP:0000012)1.94898284
110Combined immunodeficiency (HP:0005387)1.92640862
111Hand muscle atrophy (HP:0009130)1.92451518
112Gait imbalance (HP:0002141)1.92409333
113Bradykinesia (HP:0002067)1.91950814
114Polyphagia (HP:0002591)1.91371994
115Hyperventilation (HP:0002883)1.90356632
116Spastic tetraplegia (HP:0002510)1.89870424
117Failure to thrive in infancy (HP:0001531)1.89788744
118Vacuolated lymphocytes (HP:0001922)1.89317260
119Ocular albinism (HP:0001107)1.89278675
120Clonus (HP:0002169)1.89243366
121Lower limb muscle weakness (HP:0007340)1.87130738
122Granulocytopenia (HP:0001913)1.86857519
123Diminished motivation (HP:0000745)1.86597531
124Urinary glycosaminoglycan excretion (HP:0003541)1.85635448
125Mucopolysacchariduria (HP:0008155)1.85635448
126Abnormality of oral frenula (HP:0000190)1.84130111
127Vasculitis (HP:0002633)1.83643353
128Drooling (HP:0002307)1.82727888
129Excessive salivation (HP:0003781)1.82727888
130Delusions (HP:0000746)1.81839830
131Status epilepticus (HP:0002133)1.81365651
132Obstructive sleep apnea (HP:0002870)1.81268893
133Broad metatarsal (HP:0001783)1.80411128
134Frequent falls (HP:0002359)1.79482940
135Vertigo (HP:0002321)1.79295244
136IgG deficiency (HP:0004315)1.78756869
137Inappropriate behavior (HP:0000719)1.77997065
138Aqueductal stenosis (HP:0002410)1.77951112
139Recurrent fungal infections (HP:0002841)1.77637593
140Torticollis (HP:0000473)1.77202226
141Broad alveolar ridges (HP:0000187)1.76474384
142Medial flaring of the eyebrow (HP:0010747)1.76055408
143Abnormal gallbladder physiology (HP:0012438)1.75086036
144Cholecystitis (HP:0001082)1.75086036
145Cerebral aneurysm (HP:0004944)1.73507585
146Hyperacusis (HP:0010780)1.72693059
147Epileptiform EEG discharges (HP:0011182)1.71820129
148J-shaped sella turcica (HP:0002680)1.71512427
149Arterial tortuosity (HP:0005116)1.71031169
150Agitation (HP:0000713)1.70450020
151Gait ataxia (HP:0002066)1.69603953
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68701455
153Absent speech (HP:0001344)1.66343034
154Distal upper limb amyotrophy (HP:0007149)1.65810354
155Upper limb amyotrophy (HP:0009129)1.65810354
156Trigonocephaly (HP:0000243)1.65052118
157Clumsiness (HP:0002312)1.64693481
158Focal dystonia (HP:0004373)1.63929555
159Deeply set eye (HP:0000490)1.61713262
160Incomplete penetrance (HP:0003829)1.60934379
161Psychosis (HP:0000709)1.58543638
162Lower limb amyotrophy (HP:0007210)1.58371653
163Rigidity (HP:0002063)1.58086817
164EEG with generalized epileptiform discharges (HP:0011198)1.57864894
165Iris hypopigmentation (HP:0007730)1.56913380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.00402832
2EPHA43.88931083
3EPHA33.32564705
4MAP3K93.32455879
5MINK12.98769789
6TRIM282.75424287
7DAPK22.46384141
8PAK62.45704216
9NTRK22.35146422
10TXK2.31484221
11PRPF4B2.17825308
12CAMKK12.17304498
13RIPK42.11628485
14KSR22.10273654
15MARK12.08519928
16MAP3K42.06925942
17NTRK11.96939366
18EPHB11.93709522
19KSR11.88241957
20BCR1.84389146
21FES1.79124894
22PRKD31.77529644
23MAP2K71.76211489
24MAP4K11.73102661
25CDK191.70420606
26CAMKK21.67515688
27MAP3K141.59247273
28MAP2K41.57104412
29JAK11.56073631
30TNIK1.55082348
31CDK51.54215879
32MAP3K121.54183006
33TRIB31.51645467
34DAPK11.48311653
35MAP3K131.48133372
36SIK21.42160884
37IKBKE1.39349212
38FGFR41.30090868
39PLK21.29112770
40CDK181.20667216
41TBK11.20077835
42CDK151.17112274
43PINK11.16929033
44STK381.15971246
45TYK21.15868878
46UHMK11.10024785
47TYRO31.09406304
48ZAP701.09126000
49RIPK11.07212497
50CDK141.07067675
51CDK11A1.05661140
52PRKCH1.04703297
53PRKCG1.04696595
54CAMK11.04372254
55PTK2B1.04340890
56CAMK1G1.04140473
57IRAK11.02471447
58FGFR31.01531206
59RET1.00779638
60BLK1.00760841
61CASK1.00241449
62GRK60.98465350
63TESK20.97993953
64GRK50.97525489
65CSK0.95989879
66ARAF0.94085872
67SYK0.92880333
68JAK20.92187272
69CCNB10.90358727
70DYRK1B0.87977882
71MAPK130.87862238
72MAPKAPK30.87810141
73MARK20.85137263
74STK110.84713962
75RAF10.83396307
76PKN10.83063584
77TESK10.82691182
78MAP3K60.82495588
79BCKDK0.82423587
80DMPK0.82087140
81IKBKB0.80954108
82PNCK0.80222254
83IRAK40.79875813
84LMTK20.78738550
85PHKG20.78687654
86PHKG10.78687654
87HCK0.78168318
88FGR0.77548997
89ROCK20.77519811
90CHUK0.76961875
91MAP3K20.75624378
92MARK30.75202906
93MAP3K70.75131804
94TNK20.74663799
95ALK0.74612685
96WNK30.74150957
97SIK30.74130759
98GRK70.73210614
99BRD40.72715907
100CAMK2A0.72595780
101FYN0.72388833
102DYRK20.71697763
103TAOK30.71457290
104FER0.70083257
105LCK0.69564615
106TAOK20.69385223
107CAMK2B0.69366256
108ITK0.69056200
109PDK10.67808397
110TAOK10.67601537
111DYRK1A0.66857675
112MAP3K50.66567589
113CLK10.66029566
114PIM20.65839180
115PDPK10.65512961
116LIMK10.63416815
117JAK30.61742131
118SGK2230.61292719
119SGK4940.61292719
120OXSR10.61106309
121NEK60.58323581
122PAK30.56916007
123PRKCQ0.55991945
124SGK30.55711221
125YES10.55026638
126BMX0.53665539
127CSNK1G30.53576577
128PDGFRA0.53494440
129ERBB30.53379869
130DDR20.51374943
131MAP3K110.50780351
132CDC42BPA0.50491877
133MAP3K10.50233089
134CSF1R0.49969335
135MAPK110.49613950
136SGK10.49403160
137LYN0.49213104
138BTK0.48628286
139DAPK30.46430662
140SRC0.46255716
141IRAK20.45996651
142CAMK40.44573437
143MAPK120.44057653
144MAPK70.42779454
145PRKCE0.42595871
146RPS6KA30.40922080
147FGFR10.40682215
148ADRBK10.40192749
149MATK0.40115491
150SGK20.39888847
151MAPK100.38773840
152CSNK1G20.37902383
153MAP2K60.37032243

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.09806011
2Synaptic vesicle cycle_Homo sapiens_hsa047212.71568629
3Circadian entrainment_Homo sapiens_hsa047132.46432560
4Glutamatergic synapse_Homo sapiens_hsa047242.40232740
5Long-term potentiation_Homo sapiens_hsa047202.39903580
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33607867
7GABAergic synapse_Homo sapiens_hsa047272.24748004
8Olfactory transduction_Homo sapiens_hsa047402.23299708
9Morphine addiction_Homo sapiens_hsa050322.19272109
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07701870
11Amphetamine addiction_Homo sapiens_hsa050311.98183823
12Salivary secretion_Homo sapiens_hsa049701.94632843
13Dopaminergic synapse_Homo sapiens_hsa047281.88077881
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79847674
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79328687
16Cholinergic synapse_Homo sapiens_hsa047251.74997540
17Gastric acid secretion_Homo sapiens_hsa049711.73689213
18Primary immunodeficiency_Homo sapiens_hsa053401.69386852
19Long-term depression_Homo sapiens_hsa047301.68095421
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62568115
21T cell receptor signaling pathway_Homo sapiens_hsa046601.61013482
22Insulin secretion_Homo sapiens_hsa049111.59483108
23Oxytocin signaling pathway_Homo sapiens_hsa049211.58446890
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55829085
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.55603861
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55069470
27GnRH signaling pathway_Homo sapiens_hsa049121.46314719
28Calcium signaling pathway_Homo sapiens_hsa040201.42311464
29Renin secretion_Homo sapiens_hsa049241.41614186
30Serotonergic synapse_Homo sapiens_hsa047261.38335667
31Taste transduction_Homo sapiens_hsa047421.38023888
32Rheumatoid arthritis_Homo sapiens_hsa053231.34929575
33TNF signaling pathway_Homo sapiens_hsa046681.34390413
34Cocaine addiction_Homo sapiens_hsa050301.33221992
35Measles_Homo sapiens_hsa051621.32830950
36Gap junction_Homo sapiens_hsa045401.32708347
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31708123
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29106422
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.27418825
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26279030
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26242607
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25922916
43Glioma_Homo sapiens_hsa052141.25864490
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25353924
45cAMP signaling pathway_Homo sapiens_hsa040241.19868791
46Regulation of autophagy_Homo sapiens_hsa041401.18750679
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18564361
48Axon guidance_Homo sapiens_hsa043601.18444061
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17909390
50Malaria_Homo sapiens_hsa051441.17553675
51Estrogen signaling pathway_Homo sapiens_hsa049151.16483628
52Lysosome_Homo sapiens_hsa041421.16170147
53Tuberculosis_Homo sapiens_hsa051521.14627316
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13846072
55Phagosome_Homo sapiens_hsa041451.11480292
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.08985062
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07944918
58Leishmaniasis_Homo sapiens_hsa051401.07422377
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.06458301
60ErbB signaling pathway_Homo sapiens_hsa040121.05912126
61Graft-versus-host disease_Homo sapiens_hsa053321.04380532
62Legionellosis_Homo sapiens_hsa051341.02111786
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.00903586
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00476781
65Type II diabetes mellitus_Homo sapiens_hsa049300.98191751
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97273600
67Melanogenesis_Homo sapiens_hsa049160.96722037
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94992968
69VEGF signaling pathway_Homo sapiens_hsa043700.94484172
70Collecting duct acid secretion_Homo sapiens_hsa049660.94128923
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92264802
72Pertussis_Homo sapiens_hsa051330.85266937
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.84536888
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.84216453
75Prolactin signaling pathway_Homo sapiens_hsa049170.83653658
76Rap1 signaling pathway_Homo sapiens_hsa040150.83351273
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81806594
78Choline metabolism in cancer_Homo sapiens_hsa052310.81668420
79Type I diabetes mellitus_Homo sapiens_hsa049400.81231537
80Herpes simplex infection_Homo sapiens_hsa051680.80929265
81Influenza A_Homo sapiens_hsa051640.80730123
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80063776
83Pancreatic secretion_Homo sapiens_hsa049720.80045239
84Hepatitis B_Homo sapiens_hsa051610.79974257
85MAPK signaling pathway_Homo sapiens_hsa040100.79772663
86Hepatitis C_Homo sapiens_hsa051600.78792132
87Dilated cardiomyopathy_Homo sapiens_hsa054140.78408450
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78176726
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77522482
90Other glycan degradation_Homo sapiens_hsa005110.76660987
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76056133
92Toxoplasmosis_Homo sapiens_hsa051450.75764706
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75151996
94Endocytosis_Homo sapiens_hsa041440.75068798
95Dorso-ventral axis formation_Homo sapiens_hsa043200.74781790
96* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74278401
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74237463
98Oocyte meiosis_Homo sapiens_hsa041140.74007078
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72212175
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.71837497
101Allograft rejection_Homo sapiens_hsa053300.71585553
102Platelet activation_Homo sapiens_hsa046110.71365497
103Vibrio cholerae infection_Homo sapiens_hsa051100.71094648
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70664027
105Chemokine signaling pathway_Homo sapiens_hsa040620.70312340
106Acute myeloid leukemia_Homo sapiens_hsa052210.69474333
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68341961
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67849116
109African trypanosomiasis_Homo sapiens_hsa051430.67643080
110Thyroid hormone synthesis_Homo sapiens_hsa049180.67442683
111Ras signaling pathway_Homo sapiens_hsa040140.64145845
112Hematopoietic cell lineage_Homo sapiens_hsa046400.62758522
113Non-small cell lung cancer_Homo sapiens_hsa052230.62492281
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62488728
115Renal cell carcinoma_Homo sapiens_hsa052110.61969052
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61695877
117Apoptosis_Homo sapiens_hsa042100.61579480
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60735010
119Endometrial cancer_Homo sapiens_hsa052130.60569124
120Colorectal cancer_Homo sapiens_hsa052100.59256180
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58911744
122Inositol phosphate metabolism_Homo sapiens_hsa005620.57895080
123mTOR signaling pathway_Homo sapiens_hsa041500.57517519
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57179094
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56924643
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56459760
127Staphylococcus aureus infection_Homo sapiens_hsa051500.56350632
128Notch signaling pathway_Homo sapiens_hsa043300.56329732
129Autoimmune thyroid disease_Homo sapiens_hsa053200.55446783
130Antigen processing and presentation_Homo sapiens_hsa046120.55419837
131FoxO signaling pathway_Homo sapiens_hsa040680.54869720
132Proteoglycans in cancer_Homo sapiens_hsa052050.54833888
133B cell receptor signaling pathway_Homo sapiens_hsa046620.53202611
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52137193
135Salmonella infection_Homo sapiens_hsa051320.48893493
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48206205
137Cardiac muscle contraction_Homo sapiens_hsa042600.47984248
138Alcoholism_Homo sapiens_hsa050340.47290669
139* Shigellosis_Homo sapiens_hsa051310.46604543
140Chronic myeloid leukemia_Homo sapiens_hsa052200.46555040
141Focal adhesion_Homo sapiens_hsa045100.45691353
142Phototransduction_Homo sapiens_hsa047440.45529634
143Circadian rhythm_Homo sapiens_hsa047100.44685893
144Wnt signaling pathway_Homo sapiens_hsa043100.43094397
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43086594
146Osteoclast differentiation_Homo sapiens_hsa043800.42245713

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