ELMO2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.07768328
2regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.01859461
3cell migration in hindbrain (GO:0021535)5.27676586
4pyrimidine nucleobase catabolic process (GO:0006208)5.03369710
5regulation of development, heterochronic (GO:0040034)4.62803987
6negative regulation of JAK-STAT cascade (GO:0046426)4.54254436
7regulation of timing of cell differentiation (GO:0048505)4.51353294
8regulation of collateral sprouting (GO:0048670)4.47707643
9nucleobase catabolic process (GO:0046113)4.37811578
10nonmotile primary cilium assembly (GO:0035058)4.34346001
11postsynaptic membrane organization (GO:0001941)4.34224761
12behavioral response to nicotine (GO:0035095)4.10500965
13regulation of cilium movement (GO:0003352)4.07731975
14cerebral cortex radially oriented cell migration (GO:0021799)4.00878897
15neurotransmitter-gated ion channel clustering (GO:0072578)4.00044296
16regulation of regulatory T cell differentiation (GO:0045589)3.99283408
17negative regulation of dendrite development (GO:2000171)3.74604622
18positive regulation of dendritic spine development (GO:0060999)3.73763923
19C4-dicarboxylate transport (GO:0015740)3.72742903
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70772299
21oxidative demethylation (GO:0070989)3.69660997
22regulation of isotype switching to IgG isotypes (GO:0048302)3.69117881
23protein-cofactor linkage (GO:0018065)3.67487361
24regulation of immunoglobulin secretion (GO:0051023)3.66795765
25positive regulation of growth hormone secretion (GO:0060124)3.63509180
26photoreceptor cell maintenance (GO:0045494)3.60825502
27negative regulation of astrocyte differentiation (GO:0048712)3.57714525
28G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.50961864
29positive regulation of interleukin-17 production (GO:0032740)3.50182600
30phosphatidylinositol acyl-chain remodeling (GO:0036149)3.49174841
31head development (GO:0060322)3.47534933
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45681212
33cAMP-mediated signaling (GO:0019933)3.40558577
34negative regulation of protein oligomerization (GO:0032460)3.40248093
35positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.37569821
36DNA double-strand break processing (GO:0000729)3.33579011
37negative regulation of calcium ion transport into cytosol (GO:0010523)3.27240929
38indolalkylamine metabolic process (GO:0006586)3.26671561
39tryptophan catabolic process (GO:0006569)3.25475945
40indole-containing compound catabolic process (GO:0042436)3.25475945
41indolalkylamine catabolic process (GO:0046218)3.25475945
42phosphatidylserine acyl-chain remodeling (GO:0036150)3.25020346
43somite development (GO:0061053)3.24383146
44cAMP catabolic process (GO:0006198)3.19966781
45axoneme assembly (GO:0035082)3.19810458
46DNA integration (GO:0015074)3.19107858
47growth hormone secretion (GO:0030252)3.18036689
48regulation of growth hormone secretion (GO:0060123)3.15497688
49phenol-containing compound catabolic process (GO:0019336)3.13057304
50signal peptide processing (GO:0006465)3.10798695
51transmission of nerve impulse (GO:0019226)3.10790628
52kynurenine metabolic process (GO:0070189)3.07923263
53protein K11-linked deubiquitination (GO:0035871)3.07669522
54phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.06935142
55gamma-aminobutyric acid transport (GO:0015812)3.03028532
56negative regulation of B cell apoptotic process (GO:0002903)3.00453695
57protein localization to synapse (GO:0035418)2.99413815
58DNA demethylation (GO:0080111)2.93714736
59regulation of microtubule-based movement (GO:0060632)2.92735966
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91606170
61protein polyglutamylation (GO:0018095)2.90307603
62protein prenylation (GO:0018342)2.86974054
63prenylation (GO:0097354)2.86974054
64cellular biogenic amine catabolic process (GO:0042402)2.84963966
65amine catabolic process (GO:0009310)2.84963966
66regulation of dendritic spine development (GO:0060998)2.83722822
67dopamine transport (GO:0015872)2.82341623
68retinal cone cell development (GO:0046549)2.80812012
69neuron cell-cell adhesion (GO:0007158)2.80123254
70sequestering of actin monomers (GO:0042989)2.78836641
71cyclic nucleotide catabolic process (GO:0009214)2.77227867
72hippocampus development (GO:0021766)2.74516876
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69753305
74indole-containing compound metabolic process (GO:0042430)2.68871770
75inner ear receptor stereocilium organization (GO:0060122)2.67120461
76regulation of JAK-STAT cascade (GO:0046425)2.65469210
77protein localization to cilium (GO:0061512)2.64972652
78ganglion development (GO:0061548)2.64161110
79phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.63028892
80neurotransmitter biosynthetic process (GO:0042136)2.62976552
81positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)2.62763589
82acrosome reaction (GO:0007340)2.61722154
83adult walking behavior (GO:0007628)2.61375181
84cullin deneddylation (GO:0010388)2.61233149
85presynaptic membrane assembly (GO:0097105)2.58704606
86central nervous system projection neuron axonogenesis (GO:0021952)2.57437246
87negative regulation of axonogenesis (GO:0050771)2.57077696
88regulation of memory T cell differentiation (GO:0043380)2.56793654
89ionotropic glutamate receptor signaling pathway (GO:0035235)2.56525282
90central nervous system neuron axonogenesis (GO:0021955)2.56268416
91detection of light stimulus involved in sensory perception (GO:0050962)2.55147650
92detection of light stimulus involved in visual perception (GO:0050908)2.55147650
93glutamate receptor signaling pathway (GO:0007215)2.54363991
94fatty acid elongation (GO:0030497)2.53928692
95midgut development (GO:0007494)2.52481436
96phosphatidylcholine acyl-chain remodeling (GO:0036151)2.51574787
97lung secretory cell differentiation (GO:0061140)2.51277089
98primary amino compound metabolic process (GO:1901160)2.51227973
99dendrite development (GO:0016358)2.49360592
100regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.48869716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.95916928
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.87442437
3IGF1R_20145208_ChIP-Seq_DFB_Human3.67156550
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.63285548
5GBX2_23144817_ChIP-Seq_PC3_Human3.37991194
6VDR_22108803_ChIP-Seq_LS180_Human3.32458241
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.22448069
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.69352554
9TAF15_26573619_Chip-Seq_HEK293_Human2.64407056
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58121193
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46759564
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45025630
13EZH2_22144423_ChIP-Seq_EOC_Human2.43994033
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20413684
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15553131
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15457681
17EWS_26573619_Chip-Seq_HEK293_Human2.10186463
18P300_19829295_ChIP-Seq_ESCs_Human2.03285352
19FUS_26573619_Chip-Seq_HEK293_Human1.98311409
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96408318
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81612697
22ER_23166858_ChIP-Seq_MCF-7_Human1.81525957
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.78016061
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73563043
25CBP_20019798_ChIP-Seq_JUKART_Human1.73563043
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.68849969
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64135107
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.64112951
29SMAD4_21799915_ChIP-Seq_A2780_Human1.61308385
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60154013
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55884790
32STAT3_23295773_ChIP-Seq_U87_Human1.52306982
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.51676016
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49814477
35AR_25329375_ChIP-Seq_VCAP_Human1.49343301
36REST_21632747_ChIP-Seq_MESCs_Mouse1.48332607
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44696025
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41787522
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40108354
40TCF4_23295773_ChIP-Seq_U87_Human1.38834286
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37963823
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.36511034
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28431403
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.26720029
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26304468
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25151682
47DROSHA_22980978_ChIP-Seq_HELA_Human1.24950471
48AR_21572438_ChIP-Seq_LNCaP_Human1.23794758
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.22028556
50BCAT_22108803_ChIP-Seq_LS180_Human1.21882443
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21467217
52TP53_22573176_ChIP-Seq_HFKS_Human1.20644283
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.19797499
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19757574
55NANOG_19829295_ChIP-Seq_ESCs_Human1.19449944
56SOX2_19829295_ChIP-Seq_ESCs_Human1.19449944
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18902253
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17793416
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17428154
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16733995
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15379932
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.14511751
63RUNX2_22187159_ChIP-Seq_PCA_Human1.13875027
64TP53_16413492_ChIP-PET_HCT116_Human1.13762766
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13003482
66TCF4_22108803_ChIP-Seq_LS180_Human1.10546952
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08674149
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08363948
69IRF1_19129219_ChIP-ChIP_H3396_Human1.08225459
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07946333
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07489754
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.06944736
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.06297540
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06023707
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.06023707
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06022085
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03699348
78MYC_19829295_ChIP-Seq_ESCs_Human1.03266931
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02959473
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02894753
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01905326
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.01902495
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.01347375
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.99387732
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98900222
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98348991
87NCOR_22424771_ChIP-Seq_293T_Human0.97834487
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97704055
89AR_19668381_ChIP-Seq_PC3_Human0.97674652
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97288895
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96271985
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95693238
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.95224314
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95129072
95RNF2_27304074_Chip-Seq_NSC_Mouse0.93462538
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93420260
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93119410
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.91970290
99TP53_18474530_ChIP-ChIP_U2OS_Human0.90633228
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.90483431

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.32887753
2MP0008789_abnormal_olfactory_epithelium3.29698984
3MP0000465_gastrointestinal_hemorrhage3.28206957
4MP0005394_taste/olfaction_phenotype3.14075744
5MP0005499_abnormal_olfactory_system3.14075744
6MP0003880_abnormal_central_pattern3.04947858
7MP0004270_analgesia3.00938822
8MP0001984_abnormal_olfaction2.82581449
9MP0002736_abnormal_nociception_after2.78683486
10MP0005551_abnormal_eye_electrophysiolog2.74079413
11MP0001968_abnormal_touch/_nociception2.68402668
12MP0001501_abnormal_sleep_pattern2.14673361
13MP0002102_abnormal_ear_morphology2.07789406
14MP0004859_abnormal_synaptic_plasticity1.93148466
15MP0008877_abnormal_DNA_methylation1.88909274
16MP0000631_abnormal_neuroendocrine_gland1.85015448
17MP0008995_early_reproductive_senescence1.82557717
18MP0006276_abnormal_autonomic_nervous1.80793149
19MP0004133_heterotaxia1.80474777
20MP0003195_calcinosis1.73912622
21MP0000778_abnormal_nervous_system1.68417961
22MP0003656_abnormal_erythrocyte_physiolo1.66491177
23MP0002734_abnormal_mechanical_nocicepti1.62855927
24MP0003635_abnormal_synaptic_transmissio1.58797921
25MP0001986_abnormal_taste_sensitivity1.58555666
26MP0008872_abnormal_physiological_respon1.51313124
27MP0002272_abnormal_nervous_system1.47125562
28MP0005386_behavior/neurological_phenoty1.45891212
29MP0004924_abnormal_behavior1.45891212
30MP0002653_abnormal_ependyma_morphology1.45628428
31MP0001905_abnormal_dopamine_level1.44956082
32MP0002572_abnormal_emotion/affect_behav1.43025234
33MP0006072_abnormal_retinal_apoptosis1.42662764
34MP0005253_abnormal_eye_physiology1.40887047
35MP0005084_abnormal_gallbladder_morpholo1.39796989
36MP0009745_abnormal_behavioral_response1.39334045
37MP0003937_abnormal_limbs/digits/tail_de1.39251427
38MP0002233_abnormal_nose_morphology1.38133218
39MP0004043_abnormal_pH_regulation1.34921513
40MP0008058_abnormal_DNA_repair1.34449657
41MP0005423_abnormal_somatic_nervous1.33228083
42MP0002557_abnormal_social/conspecific_i1.33114604
43MP0002063_abnormal_learning/memory/cond1.26257696
44MP0002067_abnormal_sensory_capabilities1.25076007
45MP0002735_abnormal_chemical_nociception1.22367288
46MP0003119_abnormal_digestive_system1.21032569
47MP0004811_abnormal_neuron_physiology1.19890111
48MP0000372_irregular_coat_pigmentation1.18296717
49MP0004215_abnormal_myocardial_fiber1.18205351
50MP0002234_abnormal_pharynx_morphology1.15608048
51MP0005195_abnormal_posterior_eye1.14234267
52MP0003786_premature_aging1.11885526
53MP0000049_abnormal_middle_ear1.11629202
54MP0004142_abnormal_muscle_tone1.10165042
55MP0009046_muscle_twitch1.09950174
56MP0000383_abnormal_hair_follicle1.09441525
57MP0002928_abnormal_bile_duct1.07236971
58MP0003868_abnormal_feces_composition1.06700396
59MP0002064_seizures1.05640972
60MP0000538_abnormal_urinary_bladder1.05348481
61MP0001853_heart_inflammation1.05252562
62MP0002837_dystrophic_cardiac_calcinosis1.04807603
63MP0002752_abnormal_somatic_nervous1.04346088
64MP0002733_abnormal_thermal_nociception1.01640670
65MP0002909_abnormal_adrenal_gland1.01260428
66MP0001270_distended_abdomen0.99454468
67MP0000647_abnormal_sebaceous_gland0.99357126
68MP0000604_amyloidosis0.96970647
69MP0001486_abnormal_startle_reflex0.96855529
70MP0003122_maternal_imprinting0.96077222
71MP0002882_abnormal_neuron_morphology0.95859433
72MP0001177_atelectasis0.91743980
73MP0001970_abnormal_pain_threshold0.91068641
74MP0002184_abnormal_innervation0.90260387
75MP0010386_abnormal_urinary_bladder0.89768245
76MP0003300_gastrointestinal_ulcer0.83131731
77MP0008260_abnormal_autophagy0.83022269
78MP0003938_abnormal_ear_development0.82193213
79MP0005367_renal/urinary_system_phenotyp0.80448169
80MP0000516_abnormal_urinary_system0.80448169
81MP0003698_abnormal_male_reproductive0.79390909
82MP0004742_abnormal_vestibular_system0.79172919
83MP0001764_abnormal_homeostasis0.78741734
84MP0002229_neurodegeneration0.78379438
85MP0002751_abnormal_autonomic_nervous0.77722521
86MP0005646_abnormal_pituitary_gland0.77059068
87MP0004782_abnormal_surfactant_physiolog0.76625965
88MP0000026_abnormal_inner_ear0.76561672
89MP0002152_abnormal_brain_morphology0.75068622
90MP0001502_abnormal_circadian_rhythm0.74971462
91MP0002277_abnormal_respiratory_mucosa0.74966460
92MP0008770_decreased_survivor_rate0.73954094
93MP0001293_anophthalmia0.72923914
94MP0002066_abnormal_motor_capabilities/c0.72787653
95MP0000955_abnormal_spinal_cord0.72435410
96MP0004147_increased_porphyrin_level0.72100970
97MP0003632_abnormal_nervous_system0.71988370
98MP0000013_abnormal_adipose_tissue0.70845550
99MP0006292_abnormal_olfactory_placode0.69990767
100MP0002876_abnormal_thyroid_physiology0.67681959

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.07845003
2Gait imbalance (HP:0002141)3.64690661
3Pancreatic cysts (HP:0001737)3.64193870
4True hermaphroditism (HP:0010459)3.61204220
5Chronic hepatic failure (HP:0100626)3.56021348
6Medial flaring of the eyebrow (HP:0010747)3.54493989
7Congenital primary aphakia (HP:0007707)3.50238428
8Abnormality of midbrain morphology (HP:0002418)3.47695932
9Molar tooth sign on MRI (HP:0002419)3.47695932
10Abnormal biliary tract physiology (HP:0012439)3.37599959
11Bile duct proliferation (HP:0001408)3.37599959
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.23516565
13Stomach cancer (HP:0012126)3.22705195
14Limb dystonia (HP:0002451)3.21008693
15Nephronophthisis (HP:0000090)3.20030387
16Nephrogenic diabetes insipidus (HP:0009806)3.17603841
17Hyperventilation (HP:0002883)3.09222991
18Renal cortical cysts (HP:0000803)3.06188481
19Drooling (HP:0002307)2.99296462
20Progressive inability to walk (HP:0002505)2.98922601
21Absent speech (HP:0001344)2.97702952
22Retinal dysplasia (HP:0007973)2.97358437
23Cortical dysplasia (HP:0002539)2.89024151
24Concave nail (HP:0001598)2.81194634
25Pancreatic fibrosis (HP:0100732)2.75689138
26Excessive salivation (HP:0003781)2.75635331
27Hypomagnesemia (HP:0002917)2.74997271
28Broad-based gait (HP:0002136)2.72477404
29Protruding tongue (HP:0010808)2.70009760
30Abnormality of the renal cortex (HP:0011035)2.69303149
31Vaginal atresia (HP:0000148)2.61430570
32Hemiparesis (HP:0001269)2.53139012
33Genital tract atresia (HP:0001827)2.51441804
34Abnormality of the renal medulla (HP:0100957)2.50562359
35Focal motor seizures (HP:0011153)2.46874334
36Abnormal rod and cone electroretinograms (HP:0008323)2.45743042
37Hypsarrhythmia (HP:0002521)2.41908508
38Amyotrophic lateral sclerosis (HP:0007354)2.41694963
39Inability to walk (HP:0002540)2.38454907
40Abnormality of cochlea (HP:0000375)2.34644271
41EEG with generalized epileptiform discharges (HP:0011198)2.29548175
42Epileptiform EEG discharges (HP:0011182)2.29410283
43Choroideremia (HP:0001139)2.27956363
44Pachygyria (HP:0001302)2.26283517
453-Methylglutaconic aciduria (HP:0003535)2.25638539
46Abnormality of the astrocytes (HP:0100707)2.22198363
47Astrocytoma (HP:0009592)2.22198363
48Abnormality of the lower motor neuron (HP:0002366)2.19434074
49Colon cancer (HP:0003003)2.17512033
50Abnormality of magnesium homeostasis (HP:0004921)2.16696089
51Bony spicule pigmentary retinopathy (HP:0007737)2.15599888
52Cystic liver disease (HP:0006706)2.14990122
53Decreased central vision (HP:0007663)2.13976904
54Pendular nystagmus (HP:0012043)2.10158773
55Poor coordination (HP:0002370)2.09688910
56Abolished electroretinogram (ERG) (HP:0000550)2.07854051
57Dyskinesia (HP:0100660)2.07063990
58Sex reversal (HP:0012245)2.06074533
59Abnormal sex determination (HP:0012244)2.06074533
60Gaze-evoked nystagmus (HP:0000640)2.03879385
61Postaxial hand polydactyly (HP:0001162)2.02826509
62Abnormality of the labia minora (HP:0012880)2.02506168
63Microvesicular hepatic steatosis (HP:0001414)2.01530517
64Tubulointerstitial nephritis (HP:0001970)2.01171916
65Hyperalaninemia (HP:0003348)1.99351282
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99351282
67Abnormality of alanine metabolism (HP:0010916)1.99351282
68Hyperglycinuria (HP:0003108)1.98611422
69Stomatitis (HP:0010280)1.98484638
70Abnormality of glycine metabolism (HP:0010895)1.98022135
71Abnormality of serine family amino acid metabolism (HP:0010894)1.98022135
72Hyperglycinemia (HP:0002154)1.97605770
73Abnormality of macular pigmentation (HP:0008002)1.95084437
74Intestinal atresia (HP:0011100)1.94954754
75Poor speech (HP:0002465)1.93387062
76Anencephaly (HP:0002323)1.93084890
77Lissencephaly (HP:0001339)1.92975076
78Thyroiditis (HP:0100646)1.91517267
79Specific learning disability (HP:0001328)1.91473612
80Brushfield spots (HP:0001088)1.90130211
81Occipital encephalocele (HP:0002085)1.88447334
82Morphological abnormality of the inner ear (HP:0011390)1.87441012
83Short foot (HP:0001773)1.87408988
84Postaxial foot polydactyly (HP:0001830)1.85749610
85Constricted visual fields (HP:0001133)1.85527908
86Narrow forehead (HP:0000341)1.85073771
87Severe combined immunodeficiency (HP:0004430)1.84289553
88Methylmalonic acidemia (HP:0002912)1.84175359
89Chorioretinal atrophy (HP:0000533)1.81850155
90Ketoacidosis (HP:0001993)1.81070267
91Retinitis pigmentosa (HP:0000510)1.79811189
92Polymicrogyria (HP:0002126)1.78604421
93Glioma (HP:0009733)1.78588215
94Aplasia/Hypoplasia of the lens (HP:0008063)1.78455646
95Growth hormone deficiency (HP:0000824)1.76879361
96Epidermoid cyst (HP:0200040)1.76543292
97Optic nerve hypoplasia (HP:0000609)1.75858520
98Congenital sensorineural hearing impairment (HP:0008527)1.75189690
99Hypoplasia of the brainstem (HP:0002365)1.75173910
100Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75173910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.61683920
2STK38L3.70868846
3MAP4K23.63420091
4MARK13.28589439
5FRK3.24624129
6WNK33.11368670
7MAP3K43.08295894
8MAP2K72.81616255
9TRIM282.61134888
10MAPK132.30135665
11GRK11.96708501
12PDK21.90964117
13PINK11.88708945
14INSRR1.83511365
15CSNK1A1L1.62006779
16CSNK1G31.59909577
17CSNK1G21.59367092
18DYRK21.58990017
19BRSK21.51086171
20CAMKK21.46852275
21CSNK1G11.46629987
22DYRK31.43339138
23ZAK1.41128904
24BCR1.38802347
25ADRBK21.34575320
26SIK31.32062466
27PNCK1.31800279
28PLK21.31196178
29OXSR11.15434141
30LATS11.12598948
31STK381.11128377
32DYRK1A1.08975671
33SIK21.07062219
34RPS6KA41.06756114
35WNK11.05739069
36PRKCE0.95907766
37EPHA30.95774989
38EPHA40.92715939
39PTK2B0.91654626
40FGFR20.90213439
41MAP3K140.86955799
42CDK180.86462767
43BLK0.86314586
44PRKCG0.85138075
45CDK150.83039848
46NUAK10.82787227
47TAOK30.81975074
48PAK30.81762610
49CSNK1A10.81460442
50CDK50.78216267
51EIF2AK10.78142152
52DAPK20.77274763
53CASK0.75437113
54PRKG20.74233075
55CDK11A0.72846964
56NTRK20.72468665
57STK390.70908811
58BRD40.70436188
59TEC0.70137291
60CSNK1D0.66214494
61CAMK2B0.66056072
62AKT30.64189287
63VRK10.61885461
64PKN10.60865626
65CDK140.60446787
66MAP2K40.59991828
67RPS6KA50.59272955
68CAMK2A0.55978829
69NTRK30.54105850
70WNK40.53164739
71PLK30.52119630
72MINK10.51577888
73PRKAA10.51435466
74BMPR1B0.50957509
75PRKCZ0.49654347
76FGR0.48985251
77ABL10.48024286
78PRKACA0.45907593
79CCNB10.45643130
80LYN0.44216453
81PHKG10.43942474
82PHKG20.43942474
83SGK20.43900287
84CDK190.42444617
85PAK60.42090269
86ADRBK10.41922895
87NME10.39379662
88PRKG10.38971765
89STK160.38376478
90CDK30.36646162
91SGK2230.36619001
92SGK4940.36619001
93SRPK10.36583731
94SYK0.34662086
95IGF1R0.34251486
96CAMK2G0.33595257
97RPS6KA30.33122902
98PIK3CG0.32911574
99MAPK90.32200669
100TAOK10.31284743

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.97883413
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.91292673
3Nicotine addiction_Homo sapiens_hsa050333.49310728
4Fatty acid biosynthesis_Homo sapiens_hsa000612.85390516
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60553115
6Circadian rhythm_Homo sapiens_hsa047102.45016566
7Ether lipid metabolism_Homo sapiens_hsa005652.43345803
8Basal transcription factors_Homo sapiens_hsa030222.34377252
9Phototransduction_Homo sapiens_hsa047442.18949285
10Regulation of autophagy_Homo sapiens_hsa041402.02277367
11Butanoate metabolism_Homo sapiens_hsa006501.88532013
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86807798
13Taste transduction_Homo sapiens_hsa047421.85543581
14Selenocompound metabolism_Homo sapiens_hsa004501.78796337
15Cocaine addiction_Homo sapiens_hsa050301.68477813
16Tryptophan metabolism_Homo sapiens_hsa003801.68332710
17Protein export_Homo sapiens_hsa030601.66257457
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65759594
19Arachidonic acid metabolism_Homo sapiens_hsa005901.63329669
20Glutamatergic synapse_Homo sapiens_hsa047241.62898760
21GABAergic synapse_Homo sapiens_hsa047271.60854718
22Morphine addiction_Homo sapiens_hsa050321.57865929
23Fatty acid elongation_Homo sapiens_hsa000621.52114105
24Propanoate metabolism_Homo sapiens_hsa006401.51481194
25Olfactory transduction_Homo sapiens_hsa047401.48248789
26Fat digestion and absorption_Homo sapiens_hsa049751.43164902
27Circadian entrainment_Homo sapiens_hsa047131.32032260
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30460795
29RNA polymerase_Homo sapiens_hsa030201.26724376
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25214173
31Long-term depression_Homo sapiens_hsa047301.24995477
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23176523
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22610735
34Amphetamine addiction_Homo sapiens_hsa050311.20280084
35Nitrogen metabolism_Homo sapiens_hsa009101.19530032
36Insulin secretion_Homo sapiens_hsa049111.17407396
37Non-homologous end-joining_Homo sapiens_hsa034501.15423225
38Serotonergic synapse_Homo sapiens_hsa047261.10690267
39Dopaminergic synapse_Homo sapiens_hsa047281.07008805
40Type II diabetes mellitus_Homo sapiens_hsa049301.04837376
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.02785491
42Fanconi anemia pathway_Homo sapiens_hsa034600.95073418
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.92613799
44Ovarian steroidogenesis_Homo sapiens_hsa049130.92453497
45Caffeine metabolism_Homo sapiens_hsa002320.92191695
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92009637
47Synaptic vesicle cycle_Homo sapiens_hsa047210.91111493
48Cholinergic synapse_Homo sapiens_hsa047250.89666500
49Fatty acid metabolism_Homo sapiens_hsa012120.89075953
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.88407479
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86961866
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84174793
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79162377
54beta-Alanine metabolism_Homo sapiens_hsa004100.78256107
55Type I diabetes mellitus_Homo sapiens_hsa049400.77643054
56Retinol metabolism_Homo sapiens_hsa008300.76699714
57Salivary secretion_Homo sapiens_hsa049700.75829724
58Chemical carcinogenesis_Homo sapiens_hsa052040.74080335
59Renin secretion_Homo sapiens_hsa049240.68521483
60Parkinsons disease_Homo sapiens_hsa050120.68469035
61Hedgehog signaling pathway_Homo sapiens_hsa043400.67690961
62N-Glycan biosynthesis_Homo sapiens_hsa005100.67405803
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65687892
64Sulfur metabolism_Homo sapiens_hsa009200.65007462
65Peroxisome_Homo sapiens_hsa041460.58661494
66Asthma_Homo sapiens_hsa053100.58161482
67Collecting duct acid secretion_Homo sapiens_hsa049660.57753475
68ABC transporters_Homo sapiens_hsa020100.56070126
69Calcium signaling pathway_Homo sapiens_hsa040200.55848833
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55705831
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55023334
72Axon guidance_Homo sapiens_hsa043600.53885511
73Oxidative phosphorylation_Homo sapiens_hsa001900.50895118
74Glycerolipid metabolism_Homo sapiens_hsa005610.49600480
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.49093503
76Ras signaling pathway_Homo sapiens_hsa040140.47190856
77Proteasome_Homo sapiens_hsa030500.46885892
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.46223764
79Allograft rejection_Homo sapiens_hsa053300.44360324
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44015326
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42432607
82Lysine degradation_Homo sapiens_hsa003100.40748405
83Shigellosis_Homo sapiens_hsa051310.40429912
84Pancreatic secretion_Homo sapiens_hsa049720.39275020
85Huntingtons disease_Homo sapiens_hsa050160.38155596
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37769910
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.36206052
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35100470
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34372265
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.29606458
91Metabolic pathways_Homo sapiens_hsa011000.29455793
92cAMP signaling pathway_Homo sapiens_hsa040240.27214884
93AMPK signaling pathway_Homo sapiens_hsa041520.25069060
94Arginine and proline metabolism_Homo sapiens_hsa003300.24672024
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24439752
96RNA degradation_Homo sapiens_hsa030180.23521437
97Gastric acid secretion_Homo sapiens_hsa049710.23468613
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22333557
99mTOR signaling pathway_Homo sapiens_hsa041500.20648360
100Alzheimers disease_Homo sapiens_hsa050100.20055282

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