ELMO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.96479453
2L-phenylalanine catabolic process (GO:0006559)6.24236031
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.24236031
4L-phenylalanine metabolic process (GO:0006558)6.08425843
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08425843
6hemidesmosome assembly (GO:0031581)5.90741832
7aromatic amino acid family catabolic process (GO:0009074)5.32583615
8cysteine metabolic process (GO:0006534)5.23221714
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.20223837
10sulfur amino acid catabolic process (GO:0000098)5.10675124
11intestinal cholesterol absorption (GO:0030299)5.02930667
12regulation of water loss via skin (GO:0033561)4.99515614
13positive regulation of Cdc42 GTPase activity (GO:0043089)4.91368057
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73241320
15indole-containing compound catabolic process (GO:0042436)4.56880392
16indolalkylamine catabolic process (GO:0046218)4.56880392
17tryptophan catabolic process (GO:0006569)4.56880392
18homocysteine metabolic process (GO:0050667)4.51404009
19glyoxylate metabolic process (GO:0046487)4.50426535
20tryptophan metabolic process (GO:0006568)4.47979240
21establishment of skin barrier (GO:0061436)4.45877060
22kynurenine metabolic process (GO:0070189)4.44150659
23urea cycle (GO:0000050)4.43048202
24urea metabolic process (GO:0019627)4.43048202
25alpha-linolenic acid metabolic process (GO:0036109)4.42053217
26bile acid biosynthetic process (GO:0006699)4.35382574
27lysine metabolic process (GO:0006553)4.32509501
28lysine catabolic process (GO:0006554)4.32509501
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27334774
30high-density lipoprotein particle remodeling (GO:0034375)4.23741863
31multicellular organismal water homeostasis (GO:0050891)4.21734243
32regulation of cholesterol homeostasis (GO:2000188)4.19086121
33nitrogen cycle metabolic process (GO:0071941)4.11716000
34protein carboxylation (GO:0018214)4.10355271
35peptidyl-glutamic acid carboxylation (GO:0017187)4.10355271
36intestinal absorption (GO:0050892)4.04838797
37amino-acid betaine metabolic process (GO:0006577)4.02256906
38activation of Rac GTPase activity (GO:0032863)4.01323345
39bile acid metabolic process (GO:0008206)4.01002620
40serine family amino acid catabolic process (GO:0009071)4.00635316
41drug transmembrane transport (GO:0006855)3.97604570
42epithelial cell-cell adhesion (GO:0090136)3.96587246
43phospholipid efflux (GO:0033700)3.91361916
44aromatic amino acid family metabolic process (GO:0009072)3.90710324
45regulation of triglyceride catabolic process (GO:0010896)3.88039856
46negative regulation of sterol transport (GO:0032372)3.87200323
47negative regulation of cholesterol transport (GO:0032375)3.87200323
48reverse cholesterol transport (GO:0043691)3.84523784
49bile acid and bile salt transport (GO:0015721)3.84441468
50drug catabolic process (GO:0042737)3.83053061
51triglyceride homeostasis (GO:0070328)3.80352677
52acylglycerol homeostasis (GO:0055090)3.80352677
53complement activation, alternative pathway (GO:0006957)3.76250721
54negative regulation of fibrinolysis (GO:0051918)3.75343066
55regulation of protein activation cascade (GO:2000257)3.74396002
56GDP-mannose metabolic process (GO:0019673)3.71831035
57regulation of cholesterol esterification (GO:0010872)3.70936318
58regulation of fibrinolysis (GO:0051917)3.69208076
59cellular modified amino acid catabolic process (GO:0042219)3.68087380
60tyrosine metabolic process (GO:0006570)3.67372185
61valine metabolic process (GO:0006573)3.66145702
62alpha-amino acid catabolic process (GO:1901606)3.64575511
63positive regulation of epidermal cell differentiation (GO:0045606)3.64346768
64cellular ketone body metabolic process (GO:0046950)3.64312591
65regulation of bile acid biosynthetic process (GO:0070857)3.59711306
66positive regulation of keratinocyte differentiation (GO:0045618)3.59151173
67regulation of complement activation (GO:0030449)3.52316461
68cellular amino acid catabolic process (GO:0009063)3.51821054
69COPI coating of Golgi vesicle (GO:0048205)3.50287351
70Golgi transport vesicle coating (GO:0048200)3.50287351
71plasma lipoprotein particle assembly (GO:0034377)3.48672220
72protein-lipid complex remodeling (GO:0034368)3.48092086
73macromolecular complex remodeling (GO:0034367)3.48092086
74plasma lipoprotein particle remodeling (GO:0034369)3.48092086
75fatty acid oxidation (GO:0019395)3.46287009
76fatty acid beta-oxidation (GO:0006635)3.46277070
77response to nitrosative stress (GO:0051409)3.44962077
78flavonoid metabolic process (GO:0009812)3.44798340
79urate metabolic process (GO:0046415)3.44418555
80benzene-containing compound metabolic process (GO:0042537)3.43015833
81water homeostasis (GO:0030104)3.42592901
82short-chain fatty acid metabolic process (GO:0046459)3.41631069
83branching involved in mammary gland duct morphogenesis (GO:0060444)3.40320192
84ethanol oxidation (GO:0006069)3.39850865
85cholesterol efflux (GO:0033344)3.38899188
86cellular glucuronidation (GO:0052695)3.38373948
87lipid oxidation (GO:0034440)3.37059350
88epithelial cell differentiation involved in prostate gland development (GO:0060742)3.36444879
894-hydroxyproline metabolic process (GO:0019471)3.36284190
90serine family amino acid metabolic process (GO:0009069)3.35555805
91cholesterol homeostasis (GO:0042632)3.33285622
92indolalkylamine metabolic process (GO:0006586)3.32902570
93positive regulation of triglyceride lipase activity (GO:0061365)3.32490154
94positive regulation of lipoprotein lipase activity (GO:0051006)3.32490154
95proline biosynthetic process (GO:0006561)3.30691669
96drug metabolic process (GO:0017144)3.29328660
97sterol homeostasis (GO:0055092)3.28639743
98cell-substrate junction assembly (GO:0007044)3.28393312
99drug transport (GO:0015893)3.27996336
100peptidyl-tyrosine autophosphorylation (GO:0038083)3.26963121
101glutamate metabolic process (GO:0006536)3.26655680
102phospholipid homeostasis (GO:0055091)3.26405202
103angiotensin maturation (GO:0002003)3.24991774
104fatty acid catabolic process (GO:0009062)3.24708979
105carboxylic acid catabolic process (GO:0046395)3.22780861
106organic acid catabolic process (GO:0016054)3.22780861
107lipoprotein metabolic process (GO:0042157)3.22312755
108semaphorin-plexin signaling pathway (GO:0071526)3.22206426
109plasma lipoprotein particle clearance (GO:0034381)3.20582196
110monocarboxylic acid catabolic process (GO:0072329)3.20460820
111xenobiotic catabolic process (GO:0042178)3.15415128
112regulation of viral release from host cell (GO:1902186)3.15178635
113glycine metabolic process (GO:0006544)3.14002915
114COPII vesicle coating (GO:0048208)3.13577270
115protein-lipid complex assembly (GO:0065005)3.13114567
116coenzyme catabolic process (GO:0009109)3.12066559
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11983164
118carnitine metabolic process (GO:0009437)3.11812870
119very-low-density lipoprotein particle assembly (GO:0034379)3.11593088
120ketone body metabolic process (GO:1902224)3.11484493
121mannose metabolic process (GO:0006013)3.10871100
122exogenous drug catabolic process (GO:0042738)3.10755926
123negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.07938322
124positive regulation of epidermis development (GO:0045684)3.06784406
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.06718347
126glucose 6-phosphate metabolic process (GO:0051156)3.06477019
127surfactant homeostasis (GO:0043129)3.06156325
128negative regulation of viral release from host cell (GO:1902187)3.01346503
129NADH metabolic process (GO:0006734)3.01190042
130glutathione biosynthetic process (GO:0006750)3.00405677
131apoptotic process involved in morphogenesis (GO:0060561)3.00130544
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93946745
133intestinal epithelial cell development (GO:0060576)2.91574169
134regulation of Cdc42 GTPase activity (GO:0043088)2.89923728
135atrioventricular valve morphogenesis (GO:0003181)2.89591243
136negative regulation of cell size (GO:0045792)2.89265771
137regulation of cholesterol metabolic process (GO:0090181)2.85455615
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.85347976
139amyloid precursor protein metabolic process (GO:0042982)2.84149262
140cell-cell junction maintenance (GO:0045217)2.78839160
141amyloid precursor protein catabolic process (GO:0042987)2.77907261
142endothelial cell chemotaxis (GO:0035767)2.77487191
143peptide catabolic process (GO:0043171)2.77008261
144regulation of cholesterol biosynthetic process (GO:0045540)2.75089403
145nonribosomal peptide biosynthetic process (GO:0019184)2.73817242
146maternal placenta development (GO:0001893)2.73681945
147positive regulation of histone deacetylation (GO:0031065)2.72938292
148regulation of extracellular matrix disassembly (GO:0010715)2.70618787
149regulation of endothelial cell chemotaxis (GO:2001026)2.69265026
150regulation of keratinocyte differentiation (GO:0045616)2.68363281
151protein localization to endosome (GO:0036010)2.68270334
152regulation of fatty acid beta-oxidation (GO:0031998)2.65668245
153regulation of ruffle assembly (GO:1900027)2.64254880
154maintenance of gastrointestinal epithelium (GO:0030277)2.63233899
155protein retention in ER lumen (GO:0006621)2.63218152
156cell-substrate adherens junction assembly (GO:0007045)2.62650915
157focal adhesion assembly (GO:0048041)2.62650915
158fructose metabolic process (GO:0006000)2.62006082
159regulation of apoptotic process involved in morphogenesis (GO:1902337)2.61404756
160regulation of integrin activation (GO:0033623)2.61124625
161adherens junction assembly (GO:0034333)2.60543788
162NIK/NF-kappaB signaling (GO:0038061)2.59826516
163proline metabolic process (GO:0006560)2.56248938
164keratinocyte proliferation (GO:0043616)2.55803432
165phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.52761901
166response to food (GO:0032094)2.51228035
167regulation of vitamin metabolic process (GO:0030656)2.49818856
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.49340369
169regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.48998050
170sphingomyelin metabolic process (GO:0006684)2.47624879
171negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46495464
172tight junction assembly (GO:0070830)2.46091288
173positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.44378936
174cellular response to virus (GO:0098586)2.44224075
175positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44118442
176negative regulation of erythrocyte differentiation (GO:0045647)2.44113961
177glutamine family amino acid biosynthetic process (GO:0009084)2.44054056
178positive regulation of pseudopodium assembly (GO:0031274)2.43666817
179embryonic process involved in female pregnancy (GO:0060136)2.42221987
180glucose catabolic process (GO:0006007)2.41849899
181dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41076299
182regulation of glucose import in response to insulin stimulus (GO:2001273)2.39898630
183ear development (GO:0043583)2.38547730
184negative regulation of fatty acid transport (GO:2000192)2.38246403
185activation of MAPKKK activity (GO:0000185)2.37870971
186citrulline biosynthetic process (GO:0019240)2.37194830
187cell differentiation involved in embryonic placenta development (GO:0060706)2.37143220
188citrulline metabolic process (GO:0000052)2.35450367
189epoxygenase P450 pathway (GO:0019373)2.35078977
190striated muscle atrophy (GO:0014891)2.34996407
191trophectodermal cell differentiation (GO:0001829)2.34058294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.71953501
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.52798472
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.88464104
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.21802574
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.96834543
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.10066372
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09834157
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.97724522
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.93837357
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.19732356
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.04020991
12GATA1_22025678_ChIP-Seq_K562_Human2.88756044
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39216592
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.35300130
15VDR_21846776_ChIP-Seq_THP-1_Human2.23033827
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.22662725
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16817387
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13870829
19CLOCK_20551151_ChIP-Seq_293T_Human2.09022817
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97902047
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94495212
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91599430
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90343922
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89712560
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.86515435
26GATA4_25053715_ChIP-Seq_YYC3_Human1.84694981
27TCF7_22412390_ChIP-Seq_EML_Mouse1.79304407
28MYC_22102868_ChIP-Seq_BL_Human1.77728010
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.69679423
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69174680
31* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65049631
32P68_20966046_ChIP-Seq_HELA_Human1.64706394
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.63159609
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58673254
35GATA6_25053715_ChIP-Seq_YYC3_Human1.55523280
36KDM2B_26808549_Chip-Seq_DND41_Human1.54947143
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.54442798
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.54295808
39SMC4_20622854_ChIP-Seq_HELA_Human1.53488858
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.52608277
41ZNF263_19887448_ChIP-Seq_K562_Human1.52324849
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51991603
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.51496274
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50159119
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45075945
46KDM2B_26808549_Chip-Seq_K562_Human1.43754858
47* SA1_27219007_Chip-Seq_ERYTHROID_Human1.43712102
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38068945
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36974700
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34471242
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30769563
52VDR_24763502_ChIP-Seq_THP-1_Human1.29589668
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29012932
54TP63_22573176_ChIP-Seq_HFKS_Human1.28658856
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.28292067
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.27812848
57KLF5_25053715_ChIP-Seq_YYC3_Human1.26737648
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23096296
59* SOX2_20726797_ChIP-Seq_SW620_Human1.22491015
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22015304
61BCL6_27268052_Chip-Seq_Bcells_Human1.21020424
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19548215
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18765740
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18449832
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18153943
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16914268
67RACK7_27058665_Chip-Seq_MCF-7_Human1.16063109
68CTCF_27219007_Chip-Seq_Bcells_Human1.14964838
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13756022
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13581299
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13308930
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12224975
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12020437
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11082752
75NCOR1_26117541_ChIP-Seq_K562_Human1.10422314
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10115159
77* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07201325
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06868295
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06816500
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06746799
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05140033
82MAF_26560356_Chip-Seq_TH1_Human1.04165368
83TP53_22127205_ChIP-Seq_IMR90_Human1.03233645
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03206916
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02641494
86GATA1_19941826_ChIP-Seq_K562_Human1.02421372
87E2F1_20622854_ChIP-Seq_HELA_Human1.02350732
88LXR_22292898_ChIP-Seq_THP-1_Human1.02159074
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.00987201
90PHF8_20622854_ChIP-Seq_HELA_Human1.00919635
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00891598
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.00567896
93SA1_27219007_Chip-Seq_Bcells_Human0.99871729
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.99828730
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99462142
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99376078
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98785208
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95663080
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95025652
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94034214
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.92073898
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91656893
103* GATA3_24758297_ChIP-Seq_MCF-7_Human0.91120815
104RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90299693
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90081420
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.88949721
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87936492
108ATF3_27146783_Chip-Seq_COLON_Human0.87932622
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87665821
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.87262507
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85670891
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85656836
113GATA2_19941826_ChIP-Seq_K562_Human0.84633687
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83259896
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82850223
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82106128
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81180189
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81156409
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80272386
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79699679
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78575818
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.77652611
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76218967
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76199088
125CREB1_26743006_Chip-Seq_LNCaP_Human0.75458340
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73737255
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72189502
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71905625
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71881950
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71881950
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71254978
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.70664219
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70000395
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.69325092
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64854236
136AR_20517297_ChIP-Seq_VCAP_Human0.64766396
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64574370
138* GATA1_19941827_ChIP-Seq_MEL_Mouse0.63765313
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62765445
140ERG_20517297_ChIP-Seq_VCAP_Human0.62674856
141BCOR_27268052_Chip-Seq_Bcells_Human0.61966890
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.61045183
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.61045183
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60605383
145* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60554361
146SCL_19346495_ChIP-Seq_HPC-7_Human0.59717556
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58660355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.41978223
2MP0005360_urolithiasis6.06568343
3MP0005365_abnormal_bile_salt5.24774743
4MP0005085_abnormal_gallbladder_physiolo5.06937152
5MP0008875_abnormal_xenobiotic_pharmacok4.09010252
6MP0001666_abnormal_nutrient_absorption3.59740008
7MP0003252_abnormal_bile_duct3.23340445
8MP0005083_abnormal_biliary_tract3.07225651
9MP0003806_abnormal_nucleotide_metabolis2.96133174
10MP0010329_abnormal_lipoprotein_level2.83671761
11MP0003195_calcinosis2.58214067
12MP0009840_abnormal_foam_cell2.40905092
13MP0002138_abnormal_hepatobiliary_system2.38284743
14MP0005332_abnormal_amino_acid2.26255539
15MP0004019_abnormal_vitamin_homeostasis2.24912791
16MP0005409_darkened_coat_color2.24778911
17MP0004264_abnormal_extraembryonic_tissu2.23877610
18MP0010234_abnormal_vibrissa_follicle2.18159197
19MP0002254_reproductive_system_inflammat2.07499497
20MP0003191_abnormal_cellular_cholesterol1.98515678
21MP0005076_abnormal_cell_differentiation1.95969371
22MP0009643_abnormal_urine_homeostasis1.91988130
23MP0003868_abnormal_feces_composition1.87838399
24MP0004858_abnormal_nervous_system1.87173443
25MP0000609_abnormal_liver_physiology1.83688274
26MP0002118_abnormal_lipid_homeostasis1.78224046
27MP0003300_gastrointestinal_ulcer1.77764845
28MP0005220_abnormal_exocrine_pancreas1.77748431
29MP0008260_abnormal_autophagy1.69440500
30MP0004381_abnormal_hair_follicle1.69062467
31MP0004043_abnormal_pH_regulation1.61724520
32MP0010352_gastrointestinal_tract_polyps1.60071409
33MP0005319_abnormal_enzyme/_coenzyme1.45240491
34MP0003705_abnormal_hypodermis_morpholog1.42448200
35MP0000537_abnormal_urethra_morphology1.42212623
36MP0005636_abnormal_mineral_homeostasis1.38417033
37MP0009379_abnormal_foot_pigmentation1.31037044
38MP0010771_integument_phenotype1.28216387
39MP0001764_abnormal_homeostasis1.26551195
40MP0002877_abnormal_melanocyte_morpholog1.24810945
41MP0000858_altered_metastatic_potential1.24806881
42MP0009931_abnormal_skin_appearance1.24799976
43MP0001756_abnormal_urination1.23779520
44MP0000490_abnormal_crypts_of1.21960507
45MP0002796_impaired_skin_barrier1.21495009
46MP0003436_decreased_susceptibility_to1.19131488
47MP0004185_abnormal_adipocyte_glucose1.18753583
48MP0001944_abnormal_pancreas_morphology1.16842311
49MP0004782_abnormal_surfactant_physiolog1.16801652
50MP0005023_abnormal_wound_healing1.14740877
51MP0005084_abnormal_gallbladder_morpholo1.13443681
52MP0003303_peritoneal_inflammation1.12352036
53MP0001765_abnormal_ion_homeostasis1.09047516
54MP0003172_abnormal_lysosome_physiology1.08304801
55MP0005584_abnormal_enzyme/coenzyme_acti1.06728569
56MP0003186_abnormal_redox_activity1.05756045
57MP0000627_abnormal_mammary_gland1.05190849
58MP0002078_abnormal_glucose_homeostasis1.02906159
59MP0009780_abnormal_chondrocyte_physiolo1.01984567
60MP0002693_abnormal_pancreas_physiology1.01152261
61MP0003941_abnormal_skin_development1.00243561
62MP0000598_abnormal_liver_morphology0.98384099
63MP0002098_abnormal_vibrissa_morphology0.97928633
64MP0000462_abnormal_digestive_system0.95404988
65MP0002136_abnormal_kidney_physiology0.93728706
66MP0000762_abnormal_tongue_morphology0.93205241
67MP0003656_abnormal_erythrocyte_physiolo0.91965161
68MP0005375_adipose_tissue_phenotype0.91798762
69MP0000678_abnormal_parathyroid_gland0.88840899
70MP0002249_abnormal_larynx_morphology0.86734999
71MP0010678_abnormal_skin_adnexa0.85957861
72MP0002928_abnormal_bile_duct0.84596901
73MP0009333_abnormal_splenocyte_physiolog0.84376436
74MP0003453_abnormal_keratinocyte_physiol0.84058914
75MP0000003_abnormal_adipose_tissue0.83468971
76MP0005310_abnormal_salivary_gland0.83023554
77MP0002060_abnormal_skin_morphology0.82794168
78MP0003283_abnormal_digestive_organ0.82526716
79MP0000367_abnormal_coat/_hair0.81812192
80MP0000579_abnormal_nail_morphology0.81680340
81MP0009642_abnormal_blood_homeostasis0.81318829
82MP0005408_hypopigmentation0.80904274
83MP0002089_abnormal_postnatal_growth/wei0.80545671
84MP0003183_abnormal_peptide_metabolism0.78492016
85MP0005275_abnormal_skin_tensile0.77925163
86MP0003878_abnormal_ear_physiology0.76198111
87MP0005377_hearing/vestibular/ear_phenot0.76198111
88MP0009697_abnormal_copulation0.75214222
89MP0004947_skin_inflammation0.75078334
90MP0001873_stomach_inflammation0.75069606
91MP0010155_abnormal_intestine_physiology0.74563869
92MP0005647_abnormal_sex_gland0.73505766
93MP0002876_abnormal_thyroid_physiology0.72321221
94MP0009764_decreased_sensitivity_to0.72126329
95MP0006054_spinal_hemorrhage0.70540958
96MP0000538_abnormal_urinary_bladder0.70379190
97MP0005025_abnormal_response_to0.70175815
98MP0008469_abnormal_protein_level0.69714280
99MP0000470_abnormal_stomach_morphology0.69372910
100MP0001849_ear_inflammation0.69260484
101MP0005334_abnormal_fat_pad0.69125402
102MP0010368_abnormal_lymphatic_system0.69029711
103MP0000427_abnormal_hair_cycle0.68079519
104MP0001216_abnormal_epidermal_layer0.68012040
105MP0000383_abnormal_hair_follicle0.67766608
106MP0000613_abnormal_salivary_gland0.67677831
107MP0004510_myositis0.67419548
108MP0003866_abnormal_defecation0.66856748
109MP0009765_abnormal_xenobiotic_induced0.65509731
110MP0002909_abnormal_adrenal_gland0.65439619
111MP0005451_abnormal_body_composition0.65405341
112MP0001663_abnormal_digestive_system0.65344501
113MP0009763_increased_sensitivity_to0.64279829
114MP0003879_abnormal_hair_cell0.63855737
115MP0005501_abnormal_skin_physiology0.63476805
116MP0005257_abnormal_intraocular_pressure0.62619091
117MP0005670_abnormal_white_adipose0.61560328
118MP0005166_decreased_susceptibility_to0.61482991
119MP0003953_abnormal_hormone_level0.61247190
120MP0003091_abnormal_cell_migration0.60296734
121MP0005248_abnormal_Harderian_gland0.59934803
122MP0005448_abnormal_energy_balance0.59339756
123MP0005058_abnormal_lysosome_morphology0.58672125
124MP0001845_abnormal_inflammatory_respons0.58415495
125MP0003638_abnormal_response/metabolism_0.58405602
126MP0003123_paternal_imprinting0.57637297
127MP0000566_synostosis0.56935684
128MP0001881_abnormal_mammary_gland0.56353045
129MP0009384_cardiac_valve_regurgitation0.54879519
130MP0001533_abnormal_skeleton_physiology0.53631932
131MP0001191_abnormal_skin_condition0.53254890
132MP0002148_abnormal_hypersensitivity_rea0.53198975
133MP0005381_digestive/alimentary_phenotyp0.52561360
134MP0004147_increased_porphyrin_level0.52518431
135MP0002971_abnormal_brown_adipose0.52276122
136MP0000477_abnormal_intestine_morphology0.51211630
137MP0000467_abnormal_esophagus_morphology0.50970803
138MP0002166_altered_tumor_susceptibility0.50882327
139MP0000377_abnormal_hair_follicle0.50819365
140MP0003566_abnormal_cell_adhesion0.49447203
141MP0001664_abnormal_digestion0.48161361
142MP0006036_abnormal_mitochondrial_physio0.48052780
143MP0005666_abnormal_adipose_tissue0.47705738
144MP0002896_abnormal_bone_mineralization0.47637664

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.10163813
2Intrahepatic cholestasis (HP:0001406)5.60867843
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.23802577
4Deep venous thrombosis (HP:0002625)4.80098371
5Hypoglycemic coma (HP:0001325)4.79277911
6Xanthomatosis (HP:0000991)4.78933265
7Pili torti (HP:0003777)4.71926706
8Hypobetalipoproteinemia (HP:0003563)4.61018363
9Prolonged partial thromboplastin time (HP:0003645)4.15752046
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07446413
11Gout (HP:0001997)4.06744405
12Ketosis (HP:0001946)4.00130036
13Thin bony cortex (HP:0002753)3.97417279
14Abnormal hair laboratory examination (HP:0003328)3.90438289
15Hypoglycemic seizures (HP:0002173)3.81143195
16Fat malabsorption (HP:0002630)3.77612590
17Ketoacidosis (HP:0001993)3.73360307
18Hyperglycinuria (HP:0003108)3.71365127
19Abnormality of nail color (HP:0100643)3.59298982
20Hyperammonemia (HP:0001987)3.57192586
21Flat acetabular roof (HP:0003180)3.56699375
22Abnormality of the common coagulation pathway (HP:0010990)3.53954214
23Hyperlipoproteinemia (HP:0010980)3.53518514
24Abnormality of purine metabolism (HP:0004352)3.53220016
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.52875692
26Abnormality of the intrinsic pathway (HP:0010989)3.49134742
27Hypolipoproteinemia (HP:0010981)3.48495542
28Plantar hyperkeratosis (HP:0007556)3.46689097
29Conjugated hyperbilirubinemia (HP:0002908)3.42622140
30Hyperinsulinemic hypoglycemia (HP:0000825)3.40695863
31Complement deficiency (HP:0004431)3.37012394
32Fragile nails (HP:0001808)3.29237267
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29125824
34Epidermoid cyst (HP:0200040)3.21520659
35Abnormality of serine family amino acid metabolism (HP:0010894)3.18454245
36Abnormality of glycine metabolism (HP:0010895)3.18454245
37Symptomatic seizures (HP:0011145)3.15916638
38Broad face (HP:0000283)3.14725080
39Abnormality of nucleobase metabolism (HP:0010932)3.13470566
40Hyperglycinemia (HP:0002154)3.11872144
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11087935
42Alopecia of scalp (HP:0002293)3.06969773
43Late onset (HP:0003584)3.02149386
44Hypoalphalipoproteinemia (HP:0003233)2.98675526
45Abnormality of fatty-acid metabolism (HP:0004359)2.93116003
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.92810025
47Hyperbilirubinemia (HP:0002904)2.92618596
48Joint hemorrhage (HP:0005261)2.88886800
49Abnormality of methionine metabolism (HP:0010901)2.88202657
50Thick nail (HP:0001805)2.82156035
51Generalized aminoaciduria (HP:0002909)2.79534917
52Right ventricular cardiomyopathy (HP:0011663)2.75134212
53Hyperglycemia (HP:0003074)2.74840777
54Steatorrhea (HP:0002570)2.69810735
55Atrophic scars (HP:0001075)2.69733674
56Nail dystrophy (HP:0008404)2.68504452
57Hyperactive renin-angiotensin system (HP:0000841)2.68353287
58Malnutrition (HP:0004395)2.66749547
59Palmoplantar hyperkeratosis (HP:0000972)2.66016651
60J-shaped sella turcica (HP:0002680)2.64246546
61Hyperuricemia (HP:0002149)2.60213024
62Increased purine levels (HP:0004368)2.60213024
63Abnormal blistering of the skin (HP:0008066)2.59859075
64Onycholysis (HP:0001806)2.58262586
65Metabolic acidosis (HP:0001942)2.56340278
66Hepatocellular carcinoma (HP:0001402)2.54694479
67Distal lower limb muscle weakness (HP:0009053)2.54651958
68Esophageal varix (HP:0002040)2.52799332
69Hyperparathyroidism (HP:0000843)2.51086578
70Hypercholesterolemia (HP:0003124)2.50321418
71Abnormality of the distal phalanges of the toes (HP:0010182)2.50283808
72Cervical subluxation (HP:0003308)2.50069299
73Acanthocytosis (HP:0001927)2.49604198
74Hydroxyprolinuria (HP:0003080)2.48611234
75Abnormality of proline metabolism (HP:0010907)2.48611234
76Vascular calcification (HP:0004934)2.43395842
77Hypoplasia of dental enamel (HP:0006297)2.40212232
78Ridged nail (HP:0001807)2.39320494
79Abnormality of complement system (HP:0005339)2.39130250
80Dicarboxylic aciduria (HP:0003215)2.38218956
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38218956
82Amelogenesis imperfecta (HP:0000705)2.38197465
83Distal lower limb amyotrophy (HP:0008944)2.36267873
84Abnormality of endocrine pancreas physiology (HP:0012093)2.35467675
85Abnormality of the pancreatic islet cells (HP:0006476)2.35467675
86Palmar hyperkeratosis (HP:0010765)2.34799575
87Abnormality of pyrimidine metabolism (HP:0004353)2.33971667
88Curly hair (HP:0002212)2.33223595
89Advanced eruption of teeth (HP:0006288)2.32547537
90Distal upper limb amyotrophy (HP:0007149)2.32453633
91Upper limb amyotrophy (HP:0009129)2.32453633
92Abdominal distention (HP:0003270)2.31678900
93Pancreatitis (HP:0001733)2.31252184
94Myocardial infarction (HP:0001658)2.30876940
95Alkalosis (HP:0001948)2.28316690
96Stridor (HP:0010307)2.27360172
97Axonal loss (HP:0003447)2.26337276
98Woolly hair (HP:0002224)2.26256452
99Pterygium (HP:0001059)2.25696981
100Hyperacusis (HP:0010780)2.18808192
101Delayed CNS myelination (HP:0002188)2.18634446
102Enlarged kidneys (HP:0000105)2.17498648
103Eczematoid dermatitis (HP:0000976)2.16492096
104Lip pit (HP:0100267)2.15389254
105Abnormal enzyme/coenzyme activity (HP:0012379)2.15278700
106Ileus (HP:0002595)2.14902933
107Abnormality of chloride homeostasis (HP:0011422)2.14416081
108Interstitial pulmonary disease (HP:0006530)2.12013319
109Hypotrichosis (HP:0001006)2.11708446
110Fragile skin (HP:0001030)2.10928549
111Cardiovascular calcification (HP:0011915)2.10823894
112Potter facies (HP:0002009)2.09364126
113Facial shape deformation (HP:0011334)2.09364126
114Abnormal gallbladder morphology (HP:0012437)2.09270996
115Widely patent fontanelles and sutures (HP:0004492)2.07874541
116Diaphragmatic weakness (HP:0009113)2.07570351
117Focal segmental glomerulosclerosis (HP:0000097)2.07314313
118Obstructive sleep apnea (HP:0002870)2.07223365
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06996072
120Irritability (HP:0000737)2.06946858
121Lethargy (HP:0001254)2.06689317
122Spontaneous abortion (HP:0005268)2.05465183
123Glycosuria (HP:0003076)2.04729317
124Abnormality of urine glucose concentration (HP:0011016)2.04729317
125Proximal tubulopathy (HP:0000114)2.03980268
126Dysostosis multiplex (HP:0000943)2.03625961
127Abnormality of the gastric mucosa (HP:0004295)2.02399067
128Increased IgE level (HP:0003212)2.00826225
129Germ cell neoplasia (HP:0100728)2.00126772
130Nasal polyposis (HP:0100582)1.99948822
131Abnormality of alkaline phosphatase activity (HP:0004379)1.99662077
132Mildly elevated creatine phosphokinase (HP:0008180)1.97807422
133Insulin resistance (HP:0000855)1.97380159
134Skin nodule (HP:0200036)1.97329804
135Abnormality of the nasal mucosa (HP:0000433)1.96918395
136Protuberant abdomen (HP:0001538)1.95352860
137Pancreatic islet-cell hyperplasia (HP:0004510)1.92753410
138Spastic diplegia (HP:0001264)1.91971659
139Abnormality of polysaccharide metabolism (HP:0011012)1.91730044
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91730044
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91730044
142Poikilocytosis (HP:0004447)1.91703233
143Hypophosphatemia (HP:0002148)1.90591288
144Nephrolithiasis (HP:0000787)1.90385580
145Mucopolysacchariduria (HP:0008155)1.90123870
146Urinary glycosaminoglycan excretion (HP:0003541)1.90123870
147Short nail (HP:0001799)1.90079399
148Menorrhagia (HP:0000132)1.89755835
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.89587965
150Natal tooth (HP:0000695)1.89407076
151Decreased circulating renin level (HP:0003351)1.88099062
152Easy fatigability (HP:0003388)1.87909949
153Acanthosis nigricans (HP:0000956)1.87840736
154Hemorrhage of the eye (HP:0011885)1.87740084
155Bone pain (HP:0002653)1.87162353
156Increased cerebral lipofuscin (HP:0011813)1.86924763
157Abnormality of serum amino acid levels (HP:0003112)1.86677919
158Cholelithiasis (HP:0001081)1.86571582
159Cheilitis (HP:0100825)1.86357978
160Glomerulosclerosis (HP:0000096)1.86342907
161Abnormality of the salivary glands (HP:0010286)1.85825795
162Abnormal biliary tract morphology (HP:0012440)1.85784659
163Brushfield spots (HP:0001088)1.85474778
164Loss of speech (HP:0002371)1.83788032
165Rickets (HP:0002748)1.83582991
166Gingivitis (HP:0000230)1.82934427
167Septate vagina (HP:0001153)1.82686377
168Colitis (HP:0002583)1.81458066
169Milia (HP:0001056)1.81358888
170Pustule (HP:0200039)1.80038197
171Flattened epiphyses (HP:0003071)1.79938707
172Dehydration (HP:0001944)1.79165426
173Spinal cord compression (HP:0002176)1.78782195
174Increased neuronal autofluorescent lipopigment (HP:0002074)1.78387296
175Increased connective tissue (HP:0009025)1.78149832
176Abnormality of renin-angiotensin system (HP:0000847)1.76979875
177Progressive sensorineural hearing impairment (HP:0000408)1.75635486
178Progressive hearing impairment (HP:0001730)1.74977618
179Micronodular cirrhosis (HP:0001413)1.74162235
180Ankyloglossia (HP:0010296)1.74008686
181Hyperphosphatemia (HP:0002905)1.73805210
182Villous atrophy (HP:0011473)1.73440295
183Abnormality of small intestinal villus morphology (HP:0011472)1.73440295
184Systemic lupus erythematosus (HP:0002725)1.73274536
185Polygenic inheritance (HP:0010982)1.72963195
186Elevated alkaline phosphatase (HP:0003155)1.72879367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.05627632
2BCKDK3.96574559
3INSRR3.37439319
4FRK3.36604793
5TAOK33.02572614
6FGFR42.87857908
7SMG12.87416266
8SIK12.86573215
9MAPK152.85375197
10EPHA22.74627101
11MST1R2.37151605
12PTK62.20227805
13TRIB32.13872606
14FLT32.08302527
15NME22.05517664
16MAP3K32.00256570
17PIK3CG1.92930020
18PKN21.87887051
19MAP3K21.77258602
20ICK1.74081594
21WNK41.73186377
22LATS11.65971933
23MAP2K21.65840974
24TAOK11.51131433
25EPHB11.49619433
26TESK11.47798439
27PRPF4B1.47241372
28LMTK21.43450616
29PASK1.41056356
30PTK21.39158319
31TYK21.29073722
32WNK31.27696437
33MST41.27367497
34IRAK31.27079428
35EPHA31.27034509
36MET1.19458886
37RIPK11.16592295
38MAP3K61.12012581
39MAP2K31.10581604
40NUAK11.09206290
41FER1.02390937
42MAP3K100.99190742
43CDC42BPA0.98883445
44ZAP700.97612205
45PRKD20.96222784
46ERBB40.95785015
47HIPK20.94152783
48MAP3K10.93554531
49BMX0.91659721
50MUSK0.91511940
51LRRK20.90381169
52MAPK110.89854724
53IRAK40.89512818
54JAK30.89035434
55DYRK1B0.88973214
56JAK20.87398372
57NEK90.87318421
58NME10.86542145
59TESK20.86460178
60RPS6KB20.85050230
61EPHB20.84182763
62FGFR20.83513361
63RPS6KA20.82344927
64TGFBR10.81751565
65PIM20.81388412
66TNK20.80623481
67CDK60.79187308
68PRKG20.78046688
69MAP3K70.76580902
70PIK3CA0.74647875
71ERBB20.74143450
72CAMK1D0.73887265
73ARAF0.73573782
74NLK0.73042013
75MAP2K60.72695641
76MARK20.72601513
77TAOK20.72005646
78CDK120.70810085
79MAPKAPK30.70763170
80IRAK20.70634967
81MAP3K110.69370294
82PDGFRA0.69203064
83JAK10.68844364
84PRKAA20.68706560
85TGFBR20.68643995
86RPS6KA40.68530303
87MAP3K130.67935074
88SIK30.66081039
89MTOR0.64773269
90RIPK40.64414085
91FGFR30.64271928
92PRKD30.63575636
93CHUK0.62885908
94MAP2K10.62726725
95MAP4K10.59550643
96TBK10.59282842
97PDK30.58251429
98PDK40.58251429
99RPS6KL10.58107462
100RPS6KC10.58107462
101PRKAA10.57349269
102PRKCI0.57341384
103GRK60.57249650
104GSK3A0.56642785
105EEF2K0.55848771
106IKBKE0.55676623
107DDR20.53833817
108BTK0.51346962
109STK380.49000313
110STK240.48173712
111CSK0.46997502
112MATK0.46138629
113KSR20.45114416
114CSF1R0.44092220
115MAP3K80.43226683
116IKBKB0.43213025
117PDK20.42602427
118RPS6KA60.41673601
119NEK60.41033477
120MAPKAPK20.40709411
121KDR0.40464833
122PAK40.39771166
123DAPK20.39426720
124EIF2AK30.39138071
125IRAK10.38629165
126STK38L0.38021930
127AKT30.37768763
128ILK0.36793056
129GRK10.36319537
130TIE10.36050020
131SCYL20.35340046
132PDGFRB0.34568119
133STK100.34494533
134FGR0.33661977
135ITK0.33596757
136MAP3K140.33060642
137SGK30.32810433
138PDPK10.31571322
139RET0.30295699
140CAMK1G0.29084486
141LATS20.28684253
142CDK90.27109345
143CDK70.26493639
144PRKACG0.24679547
145PRKCZ0.24519135
146BRAF0.23662477

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.47016379
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33431526
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.13961113
4Tryptophan metabolism_Homo sapiens_hsa003802.69287022
5Nitrogen metabolism_Homo sapiens_hsa009102.63425418
6Sulfur metabolism_Homo sapiens_hsa009202.57673808
7Fatty acid degradation_Homo sapiens_hsa000712.52431546
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49936453
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31907064
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31086547
11Arginine biosynthesis_Homo sapiens_hsa002202.31061760
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22292077
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14966911
14Histidine metabolism_Homo sapiens_hsa003402.10540405
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08109994
16Butanoate metabolism_Homo sapiens_hsa006502.07967488
17Fat digestion and absorption_Homo sapiens_hsa049752.01696721
18Selenocompound metabolism_Homo sapiens_hsa004501.97215108
19Folate biosynthesis_Homo sapiens_hsa007901.92434596
20Caffeine metabolism_Homo sapiens_hsa002321.91209296
21Complement and coagulation cascades_Homo sapiens_hsa046101.90382307
22Peroxisome_Homo sapiens_hsa041461.89261822
23Notch signaling pathway_Homo sapiens_hsa043301.88387258
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86509640
25Chemical carcinogenesis_Homo sapiens_hsa052041.82812661
26Propanoate metabolism_Homo sapiens_hsa006401.81008129
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79696488
28beta-Alanine metabolism_Homo sapiens_hsa004101.67881961
29PPAR signaling pathway_Homo sapiens_hsa033201.65101473
30Fatty acid metabolism_Homo sapiens_hsa012121.59002528
31Phenylalanine metabolism_Homo sapiens_hsa003601.55888140
32Starch and sucrose metabolism_Homo sapiens_hsa005001.55827588
33ABC transporters_Homo sapiens_hsa020101.53517550
34Bile secretion_Homo sapiens_hsa049761.52673689
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.51750833
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45941498
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.44020818
38Acute myeloid leukemia_Homo sapiens_hsa052211.36583418
39Retinol metabolism_Homo sapiens_hsa008301.36473048
40VEGF signaling pathway_Homo sapiens_hsa043701.33029129
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.29994761
42Pyruvate metabolism_Homo sapiens_hsa006201.28221463
43Vitamin digestion and absorption_Homo sapiens_hsa049771.27967801
44Thyroid cancer_Homo sapiens_hsa052161.23839744
45Sulfur relay system_Homo sapiens_hsa041221.23491690
46Tyrosine metabolism_Homo sapiens_hsa003501.23400108
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22348185
48Sphingolipid metabolism_Homo sapiens_hsa006001.20346064
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19435378
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16965013
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13259152
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10920802
53Chronic myeloid leukemia_Homo sapiens_hsa052201.08922250
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.06547711
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05409476
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.03332353
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.02303577
58Lysine degradation_Homo sapiens_hsa003101.01817322
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97370870
60Arginine and proline metabolism_Homo sapiens_hsa003300.96945671
61Glutathione metabolism_Homo sapiens_hsa004800.96281476
62Carbon metabolism_Homo sapiens_hsa012000.94377493
63Glycerolipid metabolism_Homo sapiens_hsa005610.93632907
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93445420
65Staphylococcus aureus infection_Homo sapiens_hsa051500.91160385
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89547505
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89313416
68Biosynthesis of amino acids_Homo sapiens_hsa012300.88730042
69Fatty acid elongation_Homo sapiens_hsa000620.87527887
70Endometrial cancer_Homo sapiens_hsa052130.85016007
71TNF signaling pathway_Homo sapiens_hsa046680.83792304
72Tight junction_Homo sapiens_hsa045300.82833073
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81360391
74Toxoplasmosis_Homo sapiens_hsa051450.81104005
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78512699
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78274997
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77550722
78Galactose metabolism_Homo sapiens_hsa000520.76290757
79Small cell lung cancer_Homo sapiens_hsa052220.75596264
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74455378
81Protein export_Homo sapiens_hsa030600.73875105
82Influenza A_Homo sapiens_hsa051640.73597945
83Amoebiasis_Homo sapiens_hsa051460.71525674
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71441568
85* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71099018
86Non-small cell lung cancer_Homo sapiens_hsa052230.70230326
87Pancreatic cancer_Homo sapiens_hsa052120.69869697
88GnRH signaling pathway_Homo sapiens_hsa049120.69227771
89Choline metabolism in cancer_Homo sapiens_hsa052310.68520582
90Fructose and mannose metabolism_Homo sapiens_hsa000510.66777116
91Protein digestion and absorption_Homo sapiens_hsa049740.65031406
92ErbB signaling pathway_Homo sapiens_hsa040120.64731284
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64586937
94Endocytosis_Homo sapiens_hsa041440.64243495
95mTOR signaling pathway_Homo sapiens_hsa041500.63680018
96Inositol phosphate metabolism_Homo sapiens_hsa005620.63674044
97B cell receptor signaling pathway_Homo sapiens_hsa046620.63440607
98Insulin resistance_Homo sapiens_hsa049310.63362634
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61196462
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61051333
101Vibrio cholerae infection_Homo sapiens_hsa051100.60522451
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60466260
103Renal cell carcinoma_Homo sapiens_hsa052110.59503020
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59309034
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58704350
106Salmonella infection_Homo sapiens_hsa051320.58084974
107Apoptosis_Homo sapiens_hsa042100.57677829
108Pentose phosphate pathway_Homo sapiens_hsa000300.57222681
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56149905
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55519769
111Vitamin B6 metabolism_Homo sapiens_hsa007500.53878609
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53247343
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52500452
114Steroid biosynthesis_Homo sapiens_hsa001000.51470025
115Mineral absorption_Homo sapiens_hsa049780.49678089
116Osteoclast differentiation_Homo sapiens_hsa043800.48832777
117Linoleic acid metabolism_Homo sapiens_hsa005910.48521519
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.48131798
119Renin-angiotensin system_Homo sapiens_hsa046140.47919855
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45046760
121Pancreatic secretion_Homo sapiens_hsa049720.43258231
122One carbon pool by folate_Homo sapiens_hsa006700.41485099
123Metabolic pathways_Homo sapiens_hsa011000.40568402
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.34265543
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.33858175
126Other glycan degradation_Homo sapiens_hsa005110.32149798
127Glucagon signaling pathway_Homo sapiens_hsa049220.25941201
128Thyroid hormone synthesis_Homo sapiens_hsa049180.23923696
129AMPK signaling pathway_Homo sapiens_hsa041520.23785488
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.22251153
131Bladder cancer_Homo sapiens_hsa052190.21891335
132Fatty acid biosynthesis_Homo sapiens_hsa000610.19469977
133N-Glycan biosynthesis_Homo sapiens_hsa005100.18742987
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14698955
135Type II diabetes mellitus_Homo sapiens_hsa049300.12535201
136Lysosome_Homo sapiens_hsa041420.10781109
137Prion diseases_Homo sapiens_hsa050200.10175537
138Hepatitis C_Homo sapiens_hsa051600.09674683
139Arachidonic acid metabolism_Homo sapiens_hsa005900.06296426
140Prolactin signaling pathway_Homo sapiens_hsa049170.05233737
141Circadian rhythm_Homo sapiens_hsa047100.02407047
142Insulin signaling pathway_Homo sapiens_hsa049100.02242130
143Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0142739

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