ELMOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95557729
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.76723075
3locomotory exploration behavior (GO:0035641)5.72508369
4vocalization behavior (GO:0071625)5.61231401
5synaptic vesicle maturation (GO:0016188)5.50129575
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30514020
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27585973
8synaptic vesicle exocytosis (GO:0016079)5.16998244
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.10962937
10regulation of glutamate receptor signaling pathway (GO:1900449)4.98818053
11regulation of long-term neuronal synaptic plasticity (GO:0048169)4.81848907
12protein localization to synapse (GO:0035418)4.77854189
13glutamate secretion (GO:0014047)4.73412239
14regulation of synaptic vesicle exocytosis (GO:2000300)4.67052491
15neuronal action potential propagation (GO:0019227)4.62625222
16exploration behavior (GO:0035640)4.58966652
17glutamate receptor signaling pathway (GO:0007215)4.58319512
18regulation of neuronal synaptic plasticity (GO:0048168)4.56294414
19regulation of synapse structural plasticity (GO:0051823)4.53158118
20cerebellar granule cell differentiation (GO:0021707)4.50710131
21neuron cell-cell adhesion (GO:0007158)4.50246701
22synaptic transmission, glutamatergic (GO:0035249)4.36637422
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.34969923
24neurotransmitter secretion (GO:0007269)4.33712399
25neuron-neuron synaptic transmission (GO:0007270)4.33332234
26regulation of synaptic vesicle transport (GO:1902803)4.23633066
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20384028
28presynaptic membrane organization (GO:0097090)4.18933311
29neurotransmitter-gated ion channel clustering (GO:0072578)4.18443992
30presynaptic membrane assembly (GO:0097105)4.17690047
31layer formation in cerebral cortex (GO:0021819)4.13605529
32long-term memory (GO:0007616)4.13390377
33dendritic spine morphogenesis (GO:0060997)4.09563442
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07503503
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.03857551
36regulation of dendritic spine morphogenesis (GO:0061001)4.01863969
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95902110
38gamma-aminobutyric acid transport (GO:0015812)3.93597355
39positive regulation of membrane potential (GO:0045838)3.86839323
40positive regulation of synapse maturation (GO:0090129)3.86470816
41regulation of postsynaptic membrane potential (GO:0060078)3.84438600
42cellular potassium ion homeostasis (GO:0030007)3.76879619
43regulation of synaptic plasticity (GO:0048167)3.75969140
44transmission of nerve impulse (GO:0019226)3.74969330
45startle response (GO:0001964)3.74052932
46neuron recognition (GO:0008038)3.71579444
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.69441374
48prepulse inhibition (GO:0060134)3.68868926
49long-term synaptic potentiation (GO:0060291)3.67858853
50response to histamine (GO:0034776)3.60757414
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.60408575
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59730795
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.57545500
54short-term memory (GO:0007614)3.57370222
55neuromuscular process controlling balance (GO:0050885)3.54217304
56behavioral defense response (GO:0002209)3.52974688
57behavioral fear response (GO:0001662)3.52974688
58neurotransmitter transport (GO:0006836)3.51502793
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49063795
60behavioral response to nicotine (GO:0035095)3.47820218
61auditory behavior (GO:0031223)3.44985741
62behavioral response to cocaine (GO:0048148)3.44363803
63pyrimidine nucleobase catabolic process (GO:0006208)3.43789040
64positive regulation of neurotransmitter secretion (GO:0001956)3.40431081
65regulation of vesicle fusion (GO:0031338)3.40037551
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39871840
67positive regulation of neurotransmitter transport (GO:0051590)3.39395054
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.38885838
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36163935
70axonal fasciculation (GO:0007413)3.34506897
71C4-dicarboxylate transport (GO:0015740)3.33924115
72regulation of dendritic spine development (GO:0060998)3.33622811
73sodium ion export (GO:0071436)3.32614101
74adult walking behavior (GO:0007628)3.32459791
75regulation of neurotransmitter levels (GO:0001505)3.31606435
76activation of protein kinase A activity (GO:0034199)3.31488891
77synaptic transmission, dopaminergic (GO:0001963)3.31397744
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31042896
79fear response (GO:0042596)3.30235224
80striatum development (GO:0021756)3.29678374
81proline transport (GO:0015824)3.28975555
82learning (GO:0007612)3.27213588
83synaptic vesicle endocytosis (GO:0048488)3.26758988
84regulation of female receptivity (GO:0045924)3.25093822
85regulation of neurotransmitter secretion (GO:0046928)3.24653314
86dendritic spine organization (GO:0097061)3.24368888
87neuromuscular synaptic transmission (GO:0007274)3.24005397
88membrane depolarization (GO:0051899)3.23753173
89neuronal ion channel clustering (GO:0045161)3.23401562
90serotonin metabolic process (GO:0042428)3.22969443
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.21810693
92response to auditory stimulus (GO:0010996)3.21572264
93cell migration in hindbrain (GO:0021535)3.21509036
94righting reflex (GO:0060013)3.20686235
95positive regulation of action potential (GO:0045760)3.19419354
96regulation of synaptic transmission, GABAergic (GO:0032228)3.18749133
97positive regulation of dendritic spine development (GO:0060999)3.17906381
98regulation of glutamate secretion (GO:0014048)3.17806497
99cellular sodium ion homeostasis (GO:0006883)3.16009146
100membrane hyperpolarization (GO:0060081)3.15618158
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15032637
102cerebellar Purkinje cell differentiation (GO:0021702)3.14219535
103cell differentiation in hindbrain (GO:0021533)3.12385089
104neuromuscular process controlling posture (GO:0050884)3.10722709
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.09720888
106response to amphetamine (GO:0001975)3.08499890
107vesicle transport along microtubule (GO:0047496)3.08452046
108regulation of neurotransmitter transport (GO:0051588)3.08298490
109urinary tract smooth muscle contraction (GO:0014848)3.07599744
110mating behavior (GO:0007617)3.07086269
111dendrite morphogenesis (GO:0048813)3.07053422
112positive regulation of synaptic transmission (GO:0050806)3.06694146
113establishment of mitochondrion localization (GO:0051654)3.06686806
114regulation of voltage-gated calcium channel activity (GO:1901385)3.06453435
115negative regulation of dendrite morphogenesis (GO:0050774)3.05015231
116cerebellar Purkinje cell layer development (GO:0021680)3.04628922
117postsynaptic membrane organization (GO:0001941)3.03658727
118glycine transport (GO:0015816)3.03140535
119synapse assembly (GO:0007416)3.02801634
120membrane depolarization during action potential (GO:0086010)3.02111236
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01002413
122negative regulation of dendrite development (GO:2000171)3.00813612
123regulation of synaptic transmission (GO:0050804)3.00592012
124synaptic transmission (GO:0007268)3.00149540
125long term synaptic depression (GO:0060292)2.99365784
126central nervous system projection neuron axonogenesis (GO:0021952)2.98728475
127retinal cone cell development (GO:0046549)2.97579664
128positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.97495349
129neurofilament cytoskeleton organization (GO:0060052)2.97154004
130nucleobase catabolic process (GO:0046113)2.95408323
131primary amino compound metabolic process (GO:1901160)2.93826890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13716632
2GBX2_23144817_ChIP-Seq_PC3_Human3.55974486
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18673381
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16879632
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14639229
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.86378910
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75059550
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75059550
9REST_21632747_ChIP-Seq_MESCs_Mouse2.73970037
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71281073
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68400777
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55795120
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55470224
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53956115
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52260556
16DROSHA_22980978_ChIP-Seq_HELA_Human2.50803386
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.49086121
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29885733
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.25667151
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23930056
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21175306
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.19877301
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.19744452
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06504160
25VDR_22108803_ChIP-Seq_LS180_Human2.04668469
26AR_21572438_ChIP-Seq_LNCaP_Human2.01695105
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97014641
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86919618
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78672320
30TAF15_26573619_Chip-Seq_HEK293_Human1.77052936
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75729890
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75700652
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73281707
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71878380
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.65124372
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63776005
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.57699838
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54944677
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45574524
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43338886
41P300_19829295_ChIP-Seq_ESCs_Human1.39530471
42ZNF274_21170338_ChIP-Seq_K562_Hela1.38926713
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34527443
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32647113
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.32220561
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31618825
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.30160780
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30019304
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.29606282
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28963783
51AR_25329375_ChIP-Seq_VCAP_Human1.24808692
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24230169
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23505396
54STAT3_23295773_ChIP-Seq_U87_Human1.21553490
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21383872
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19895239
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.19274200
58AR_19668381_ChIP-Seq_PC3_Human1.18987144
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18945987
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17761812
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17655478
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17103127
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15870097
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.15528605
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.15205376
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13668166
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13490039
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13280959
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12170910
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.11289439
71* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10803445
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10244675
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10002462
74TP53_16413492_ChIP-PET_HCT116_Human1.08427999
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07581548
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.07434993
77* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06538956
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06424172
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06209950
80TCF4_23295773_ChIP-Seq_U87_Human1.05938099
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.05674445
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.04557349
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04355584
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04051115
85IGF1R_20145208_ChIP-Seq_DFB_Human1.03810560
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03293043
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03087984
88AHR_22903824_ChIP-Seq_MCF-7_Human1.01730655
89FUS_26573619_Chip-Seq_HEK293_Human1.01289518
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.01242587
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00836608
92RNF2_27304074_Chip-Seq_NSC_Mouse1.00734005
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00495866
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00100757
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99810552
96RUNX2_22187159_ChIP-Seq_PCA_Human0.99417390
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99408934
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99246577
99CBP_20019798_ChIP-Seq_JUKART_Human0.99233142
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99233142
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98475575
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97856159
103KDM2B_26808549_Chip-Seq_K562_Human0.97706282
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97574786
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.96018226
106* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95322049
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95049284
108KDM2B_26808549_Chip-Seq_REH_Human0.95023738
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94904707
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.93950299
111TP53_18474530_ChIP-ChIP_U2OS_Human0.93487832
112BCAT_22108803_ChIP-Seq_LS180_Human0.92776379
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.91915342
114RXR_22108803_ChIP-Seq_LS180_Human0.90944831
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.89412435
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88945128
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87590522
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87575668
119JUN_21703547_ChIP-Seq_K562_Human0.86470691
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85930377
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85725471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74302263
2MP0003880_abnormal_central_pattern5.13465985
3MP0003635_abnormal_synaptic_transmissio4.34920128
4MP0002822_catalepsy4.07257031
5MP0009745_abnormal_behavioral_response3.67919187
6MP0004270_analgesia3.60701308
7MP0002063_abnormal_learning/memory/cond3.53989402
8MP0002064_seizures3.27030909
9MP0009046_muscle_twitch3.11526210
10MP0002572_abnormal_emotion/affect_behav2.94874453
11MP0001968_abnormal_touch/_nociception2.88010106
12MP0001486_abnormal_startle_reflex2.70799721
13MP0002272_abnormal_nervous_system2.70261214
14MP0005423_abnormal_somatic_nervous2.62670503
15MP0001501_abnormal_sleep_pattern2.51913592
16MP0002734_abnormal_mechanical_nocicepti2.43728566
17MP0001440_abnormal_grooming_behavior2.23592319
18MP0002736_abnormal_nociception_after2.19497157
19MP0003329_amyloid_beta_deposits2.05155243
20MP0002735_abnormal_chemical_nociception1.99023865
21MP0002733_abnormal_thermal_nociception1.91845763
22MP0002067_abnormal_sensory_capabilities1.91117168
23MP0008569_lethality_at_weaning1.90671651
24MP0001970_abnormal_pain_threshold1.88195474
25MP0002909_abnormal_adrenal_gland1.85298622
26MP0005386_behavior/neurological_phenoty1.80613975
27MP0004924_abnormal_behavior1.80613975
28MP0002184_abnormal_innervation1.76978552
29MP0002557_abnormal_social/conspecific_i1.76928372
30MP0009780_abnormal_chondrocyte_physiolo1.76822602
31MP0001529_abnormal_vocalization1.73543687
32MP0004811_abnormal_neuron_physiology1.69109187
33MP0000778_abnormal_nervous_system1.67517111
34MP0001984_abnormal_olfaction1.65230280
35MP0005646_abnormal_pituitary_gland1.59764149
36MP0003879_abnormal_hair_cell1.52863677
37MP0004885_abnormal_endolymph1.45200035
38MP0000955_abnormal_spinal_cord1.45100428
39MP0004858_abnormal_nervous_system1.45098886
40MP0002066_abnormal_motor_capabilities/c1.41610022
41MP0001188_hyperpigmentation1.41572275
42MP0006276_abnormal_autonomic_nervous1.40752328
43MP0002882_abnormal_neuron_morphology1.36757741
44MP0003633_abnormal_nervous_system1.30760212
45MP0001905_abnormal_dopamine_level1.29011170
46MP0001502_abnormal_circadian_rhythm1.24265827
47MP0004142_abnormal_muscle_tone1.22150635
48MP0004147_increased_porphyrin_level1.15678955
49MP0003787_abnormal_imprinting1.15542436
50MP0003631_nervous_system_phenotype1.13479880
51MP0008877_abnormal_DNA_methylation1.11504731
52MP0010234_abnormal_vibrissa_follicle1.10773126
53MP0005409_darkened_coat_color1.10609211
54MP0008872_abnormal_physiological_respon1.08987720
55MP0005645_abnormal_hypothalamus_physiol1.08407739
56MP0002152_abnormal_brain_morphology1.05731675
57MP0008874_decreased_physiological_sensi1.03064930
58MP0000013_abnormal_adipose_tissue1.02805907
59MP0001177_atelectasis0.99559183
60MP0005551_abnormal_eye_electrophysiolog0.98779976
61MP0004145_abnormal_muscle_electrophysio0.97886871
62MP0004043_abnormal_pH_regulation0.97852791
63MP0002837_dystrophic_cardiac_calcinosis0.96346934
64MP0003075_altered_response_to0.95488983
65MP0002069_abnormal_eating/drinking_beha0.95110686
66MP0004742_abnormal_vestibular_system0.94791427
67MP0000604_amyloidosis0.94345585
68MP0002229_neurodegeneration0.93683918
69MP0003121_genomic_imprinting0.90350177
70MP0005535_abnormal_body_temperature0.89421062
71MP0004085_abnormal_heartbeat0.88868078
72MP0000751_myopathy0.86619412
73MP0010386_abnormal_urinary_bladder0.84905133
74MP0003632_abnormal_nervous_system0.84107930
75MP0003690_abnormal_glial_cell0.82347402
76MP0000920_abnormal_myelination0.82164704
77MP0008961_abnormal_basal_metabolism0.79937617
78MP0001986_abnormal_taste_sensitivity0.79807241
79MP0002090_abnormal_vision0.78536130
80MP0003634_abnormal_glial_cell0.77632991
81MP0006072_abnormal_retinal_apoptosis0.76877064
82MP0005394_taste/olfaction_phenotype0.76783554
83MP0005499_abnormal_olfactory_system0.76783554
84MP0003122_maternal_imprinting0.76494323
85MP0005253_abnormal_eye_physiology0.76461107
86MP0002102_abnormal_ear_morphology0.74775498
87MP0001963_abnormal_hearing_physiology0.74080375
88MP0000026_abnormal_inner_ear0.72424228
89MP0004215_abnormal_myocardial_fiber0.71072478
90MP0005171_absent_coat_pigmentation0.70814777
91MP0004484_altered_response_of0.70537801
92MP0002752_abnormal_somatic_nervous0.70269985
93MP0001485_abnormal_pinna_reflex0.67321999
94MP0000631_abnormal_neuroendocrine_gland0.66612219
95MP0005167_abnormal_blood-brain_barrier0.66026273
96MP0003283_abnormal_digestive_organ0.64879216
97MP0004510_myositis0.64115046
98MP0003137_abnormal_impulse_conducting0.62840377
99MP0001664_abnormal_digestion0.60717206
100MP0008875_abnormal_xenobiotic_pharmacok0.60711648
101MP0000569_abnormal_digit_pigmentation0.59620741
102MP0001299_abnormal_eye_distance/0.55706991
103MP0002653_abnormal_ependyma_morphology0.55375616
104MP0010770_preweaning_lethality0.54917690
105MP0002082_postnatal_lethality0.54917690
106MP0010768_mortality/aging0.53903648
107MP0005377_hearing/vestibular/ear_phenot0.53685168
108MP0003878_abnormal_ear_physiology0.53685168
109MP0002876_abnormal_thyroid_physiology0.52580082
110MP0006035_abnormal_mitochondrial_morpho0.52351911
111MP0002234_abnormal_pharynx_morphology0.51321557
112MP0005187_abnormal_penis_morphology0.50442263
113MP0004233_abnormal_muscle_weight0.50241257
114MP0001943_abnormal_respiration0.49769959
115MP0005623_abnormal_meninges_morphology0.49708091
116MP0000566_synostosis0.49225240
117MP0003956_abnormal_body_size0.49200813
118MP0010769_abnormal_survival0.49084327
119MP0002638_abnormal_pupillary_reflex0.48636724
120MP0003861_abnormal_nervous_system0.48138179

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.65869418
2Myokymia (HP:0002411)7.17460980
3Focal seizures (HP:0007359)6.17736674
4Visual hallucinations (HP:0002367)5.35836772
5Atonic seizures (HP:0010819)4.87644314
6Epileptic encephalopathy (HP:0200134)4.84167836
7Febrile seizures (HP:0002373)4.58613030
8Absence seizures (HP:0002121)4.52074540
9Progressive cerebellar ataxia (HP:0002073)4.16214253
10Dialeptic seizures (HP:0011146)4.15767424
11Generalized tonic-clonic seizures (HP:0002069)4.07318351
12Action tremor (HP:0002345)3.91627092
13Broad-based gait (HP:0002136)3.87337296
14Poor eye contact (HP:0000817)3.64923711
15Hyperventilation (HP:0002883)3.51987931
16Supranuclear gaze palsy (HP:0000605)3.49950022
17Gaze-evoked nystagmus (HP:0000640)3.42632612
18Dysdiadochokinesis (HP:0002075)3.42412359
19Impaired social interactions (HP:0000735)3.36861393
20Abnormal social behavior (HP:0012433)3.36861393
21Anxiety (HP:0000739)3.32110187
22Impaired vibration sensation in the lower limbs (HP:0002166)3.30780052
23Depression (HP:0000716)3.28390889
24Dysmetria (HP:0001310)3.24165830
25Truncal ataxia (HP:0002078)3.15487958
26Amblyopia (HP:0000646)3.15191829
27Ankle clonus (HP:0011448)3.11114291
28Cerebral inclusion bodies (HP:0100314)3.02794727
29Neurofibrillary tangles (HP:0002185)2.96868676
30Mutism (HP:0002300)2.95323432
31Urinary bladder sphincter dysfunction (HP:0002839)2.93937029
32Papilledema (HP:0001085)2.88233488
33Postural instability (HP:0002172)2.86122097
34Progressive inability to walk (HP:0002505)2.84330519
35Abnormal eating behavior (HP:0100738)2.83292870
36Torticollis (HP:0000473)2.82621713
37Excessive salivation (HP:0003781)2.81863410
38Drooling (HP:0002307)2.81863410
39Scanning speech (HP:0002168)2.80096816
40Impaired smooth pursuit (HP:0007772)2.76449065
41Stereotypic behavior (HP:0000733)2.72744477
42Hemiparesis (HP:0001269)2.72551953
43Intention tremor (HP:0002080)2.71408980
44Urinary urgency (HP:0000012)2.62662592
45Focal dystonia (HP:0004373)2.62098592
46Abnormality of binocular vision (HP:0011514)2.61108108
47Diplopia (HP:0000651)2.61108108
48Genetic anticipation (HP:0003743)2.58088598
49Annular pancreas (HP:0001734)2.56598940
50Abnormality of the lower motor neuron (HP:0002366)2.48495983
51Spastic gait (HP:0002064)2.48042471
52Status epilepticus (HP:0002133)2.46300370
53Epileptiform EEG discharges (HP:0011182)2.45725396
54Bradykinesia (HP:0002067)2.43085800
55Absent speech (HP:0001344)2.42779685
56Morphological abnormality of the pyramidal tract (HP:0002062)2.42374252
57Gait imbalance (HP:0002141)2.38345109
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37556345
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.37556345
60Abnormality of ocular smooth pursuit (HP:0000617)2.36874834
61Craniofacial dystonia (HP:0012179)2.35321257
62Dysmetric saccades (HP:0000641)2.35297187
63Termporal pattern (HP:0011008)2.35255060
64Insidious onset (HP:0003587)2.35255060
65Postural tremor (HP:0002174)2.31183191
66Megalencephaly (HP:0001355)2.29898789
67EEG with generalized epileptiform discharges (HP:0011198)2.29857455
68Ventricular fibrillation (HP:0001663)2.26287720
69Hemiplegia (HP:0002301)2.25204842
70Fetal akinesia sequence (HP:0001989)2.23446944
71Inability to walk (HP:0002540)2.22457427
72Limb dystonia (HP:0002451)2.21600458
73Abnormality of the corticospinal tract (HP:0002492)2.21531717
74Generalized myoclonic seizures (HP:0002123)2.19384103
75Ankyloglossia (HP:0010296)2.18265717
76Impaired vibratory sensation (HP:0002495)2.17184557
77Hypsarrhythmia (HP:0002521)2.14642904
78Resting tremor (HP:0002322)2.11026609
79Akinesia (HP:0002304)2.09097860
80Amyotrophic lateral sclerosis (HP:0007354)2.04480474
81Pointed chin (HP:0000307)2.03821187
82Lower limb muscle weakness (HP:0007340)2.03062841
83Incomplete penetrance (HP:0003829)2.01858105
84Lower limb amyotrophy (HP:0007210)2.01619555
85Spastic tetraplegia (HP:0002510)1.99088418
86Lower limb asymmetry (HP:0100559)1.98424926
87Gait ataxia (HP:0002066)1.97850917
88Delusions (HP:0000746)1.96753663
89Neuronal loss in central nervous system (HP:0002529)1.95043824
90Spastic tetraparesis (HP:0001285)1.91672197
91Horizontal nystagmus (HP:0000666)1.91059703
92Obstructive sleep apnea (HP:0002870)1.89803530
93Esotropia (HP:0000565)1.89794720
94Cutaneous finger syndactyly (HP:0010554)1.89167587
95Abnormality of salivation (HP:0100755)1.88546788
96Inappropriate behavior (HP:0000719)1.87902709
97Psychosis (HP:0000709)1.87872381
98Blue irides (HP:0000635)1.86573223
99Abnormal EKG (HP:0003115)1.86298602
100Morphological abnormality of the middle ear (HP:0008609)1.81857738
101Polyphagia (HP:0002591)1.81819560
102Rapidly progressive (HP:0003678)1.81675677
103Aplasia involving bones of the extremities (HP:0009825)1.81414728
104Aplasia involving bones of the upper limbs (HP:0009823)1.81414728
105Aplasia of the phalanges of the hand (HP:0009802)1.81414728
106Protruding tongue (HP:0010808)1.80661635
107Sleep apnea (HP:0010535)1.80654044
108Split foot (HP:0001839)1.80631045
109Rigidity (HP:0002063)1.79676824
110Neuroendocrine neoplasm (HP:0100634)1.79605851
111Medial flaring of the eyebrow (HP:0010747)1.77742835
112Abnormality of saccadic eye movements (HP:0000570)1.76495229
113Pheochromocytoma (HP:0002666)1.76382832
114Thickened helices (HP:0000391)1.75981714
115Clonus (HP:0002169)1.74336623
116Optic nerve hypoplasia (HP:0000609)1.70692195
117Cerebral hypomyelination (HP:0006808)1.70647448
118Congenital primary aphakia (HP:0007707)1.69241144
119Specific learning disability (HP:0001328)1.69151879
120Agitation (HP:0000713)1.67851165
121Retinal dysplasia (HP:0007973)1.66724655
122Type II lissencephaly (HP:0007260)1.66638943
123True hermaphroditism (HP:0010459)1.66634275
124Prolonged QT interval (HP:0001657)1.66463879
125Pancreatic fibrosis (HP:0100732)1.66173944
126Paraplegia (HP:0010550)1.66144190
127Lissencephaly (HP:0001339)1.65742472
128Apathy (HP:0000741)1.65340492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.83677791
2NTRK34.68052004
3MAP3K93.72746125
4RIPK42.81969138
5MAP3K42.80111124
6MARK12.57262554
7MINK12.55234943
8DAPK22.38555160
9MAP2K72.34088088
10KSR22.32987209
11PAK61.97131321
12PRKD31.89790055
13NTRK21.89412073
14CAMKK11.88399807
15MAP3K121.80020135
16MAP2K41.79949474
17NTRK11.76500197
18KSR11.76207707
19PNCK1.65371869
20ARAF1.63834698
21TNIK1.62905839
22DAPK11.59879683
23CDK51.55694989
24SIK21.53734761
25MAP3K131.50920807
26FES1.49570453
27BCR1.43696790
28CASK1.42975134
29PLK21.41453826
30FRK1.36735552
31GRK51.33387087
32CAMKK21.32216350
33MAP3K21.31147737
34BMPR21.29400092
35STK381.25335380
36PRKCG1.20786248
37TYRO31.19011992
38PRPF4B1.18723376
39WNK31.18113419
40WNK41.13920992
41CDK191.13889029
42MAP4K21.10130695
43MAPK131.08169200
44RAF11.07902712
45ADRBK21.07478551
46CAMK2A1.06558518
47CAMK2B0.99868367
48UHMK10.97663250
49PTK2B0.92826512
50DYRK20.88996451
51TAOK10.88634625
52CDK180.87199715
53STK390.86730110
54STK110.86484006
55CDK150.85918245
56CAMK10.85215174
57CDK140.84941466
58CSNK1A1L0.83255431
59PKN10.82255614
60PINK10.81358532
61SGK2230.80995823
62SGK4940.80995823
63CSNK1G30.77772082
64SGK10.76098523
65PRKCH0.75671695
66CDK11A0.75201100
67RET0.70688577
68LIMK10.69731940
69DYRK1A0.68610935
70OXSR10.67507255
71MARK20.67447009
72SGK20.66561864
73PAK30.65585221
74CSNK1G10.65249933
75PHKG10.64684022
76PHKG20.64684022
77LATS20.62557144
78PDK10.62085071
79PDPK10.60817437
80FGR0.60804256
81MAP3K10.59538691
82CAMK2D0.56148771
83SGK30.55625513
84CSNK1G20.55348717
85NME10.55207231
86BMPR1B0.54524407
87PRKCZ0.53870367
88PRKCE0.53447968
89TNK20.52898890
90ALK0.51964286
91PRKG10.50501903
92CSNK1D0.49308851
93FYN0.48509813
94CAMK2G0.48312667
95MAP2K10.47875217
96RPS6KA30.47356563
97NEK60.46986055
98MAPK100.44777156
99WNK10.44711227
100MAP3K60.44182999
101MAPK120.43209220
102CSNK1A10.41971677
103CAMK1G0.40983516
104FER0.40833886
105MAP3K70.37648869
106ROCK20.37175851
107ADRBK10.36930413
108LMTK20.36751185
109DMPK0.36731567
110FGFR20.36338799
111DAPK30.36134024
112MUSK0.35546259
113BRAF0.35070372
114GRK10.34787034
115RPS6KB10.33751661
116PRKCB0.33030908
117CAMK40.32614259
118CDK30.31636783
119ERBB30.31571338
120MOS0.31413580
121TRIM280.31333276
122TAOK30.31140249
123RIPK10.30885038
124ERBB20.30235425
125ROCK10.30222693
126PRKACA0.29959095
127PRKCA0.29357425
128CDC42BPA0.29183543

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83866565
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98196230
3Long-term potentiation_Homo sapiens_hsa047202.91377529
4Olfactory transduction_Homo sapiens_hsa047402.87045747
5GABAergic synapse_Homo sapiens_hsa047272.78120335
6Circadian entrainment_Homo sapiens_hsa047132.77301696
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76505917
8Glutamatergic synapse_Homo sapiens_hsa047242.70586689
9Amphetamine addiction_Homo sapiens_hsa050312.67104264
10Morphine addiction_Homo sapiens_hsa050322.63482728
11Dopaminergic synapse_Homo sapiens_hsa047282.29096767
12Salivary secretion_Homo sapiens_hsa049702.27878946
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14004483
14Cholinergic synapse_Homo sapiens_hsa047251.95576846
15Gastric acid secretion_Homo sapiens_hsa049711.91298586
16Renin secretion_Homo sapiens_hsa049241.89756116
17Insulin secretion_Homo sapiens_hsa049111.87784281
18Cocaine addiction_Homo sapiens_hsa050301.84165909
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83701471
20Long-term depression_Homo sapiens_hsa047301.82788198
21Taste transduction_Homo sapiens_hsa047421.82691593
22Serotonergic synapse_Homo sapiens_hsa047261.78150696
23Oxytocin signaling pathway_Homo sapiens_hsa049211.74560724
24Calcium signaling pathway_Homo sapiens_hsa040201.70297663
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65967607
26GnRH signaling pathway_Homo sapiens_hsa049121.46898792
27Gap junction_Homo sapiens_hsa045401.40421934
28Collecting duct acid secretion_Homo sapiens_hsa049661.36280281
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36042216
30cAMP signaling pathway_Homo sapiens_hsa040241.32765289
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29684505
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21586568
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16439586
34Estrogen signaling pathway_Homo sapiens_hsa049151.12997638
35Phototransduction_Homo sapiens_hsa047441.11448773
36Glioma_Homo sapiens_hsa052141.10068939
37Axon guidance_Homo sapiens_hsa043601.08507927
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07758338
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06222584
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05680507
41Cardiac muscle contraction_Homo sapiens_hsa042601.05528442
42Type II diabetes mellitus_Homo sapiens_hsa049301.04161370
43Melanogenesis_Homo sapiens_hsa049161.02669778
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98893674
45ErbB signaling pathway_Homo sapiens_hsa040120.95878230
46Pancreatic secretion_Homo sapiens_hsa049720.92539535
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92282248
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91836578
49Oocyte meiosis_Homo sapiens_hsa041140.87199792
50Nitrogen metabolism_Homo sapiens_hsa009100.85531031
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.83139088
52Vibrio cholerae infection_Homo sapiens_hsa051100.81631644
53Butanoate metabolism_Homo sapiens_hsa006500.80908586
54Thyroid hormone synthesis_Homo sapiens_hsa049180.77591308
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77279520
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77215000
57Dorso-ventral axis formation_Homo sapiens_hsa043200.76502385
58Choline metabolism in cancer_Homo sapiens_hsa052310.75519493
59VEGF signaling pathway_Homo sapiens_hsa043700.71145546
60Dilated cardiomyopathy_Homo sapiens_hsa054140.69306422
61MAPK signaling pathway_Homo sapiens_hsa040100.67319234
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63110020
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62311605
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61195099
65Oxidative phosphorylation_Homo sapiens_hsa001900.58456417
66Rap1 signaling pathway_Homo sapiens_hsa040150.58438713
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58231623
68Type I diabetes mellitus_Homo sapiens_hsa049400.57870702
69Alcoholism_Homo sapiens_hsa050340.57307540
70Ras signaling pathway_Homo sapiens_hsa040140.56611466
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56330623
72Alzheimers disease_Homo sapiens_hsa050100.55113712
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.54596416
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.54285505
75Glucagon signaling pathway_Homo sapiens_hsa049220.54224492
76Ether lipid metabolism_Homo sapiens_hsa005650.53898401
77Vitamin B6 metabolism_Homo sapiens_hsa007500.53788626
78African trypanosomiasis_Homo sapiens_hsa051430.53095120
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52628827
80mTOR signaling pathway_Homo sapiens_hsa041500.48685898
81Parkinsons disease_Homo sapiens_hsa050120.48672957
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47911744
83Inositol phosphate metabolism_Homo sapiens_hsa005620.47096899
84Non-small cell lung cancer_Homo sapiens_hsa052230.46793857
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46236425
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45338918
87Bile secretion_Homo sapiens_hsa049760.44855771
88Circadian rhythm_Homo sapiens_hsa047100.42988995
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41637647
90Endocytosis_Homo sapiens_hsa041440.40745367
91Regulation of autophagy_Homo sapiens_hsa041400.40518962
92Prion diseases_Homo sapiens_hsa050200.39968480
93Linoleic acid metabolism_Homo sapiens_hsa005910.38887977
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37685654
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37035985
96Wnt signaling pathway_Homo sapiens_hsa043100.36241503
97Renal cell carcinoma_Homo sapiens_hsa052110.35877045
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35077232
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34271873
100Chemokine signaling pathway_Homo sapiens_hsa040620.33393690
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33311566
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32447444
103ABC transporters_Homo sapiens_hsa020100.30216362
104Endometrial cancer_Homo sapiens_hsa052130.29357500
105Ovarian steroidogenesis_Homo sapiens_hsa049130.28708509
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28322071
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28151648
108Hippo signaling pathway_Homo sapiens_hsa043900.28025266
109Tight junction_Homo sapiens_hsa045300.27741537
110Insulin signaling pathway_Homo sapiens_hsa049100.27691999
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27556046
112Huntingtons disease_Homo sapiens_hsa050160.25999159
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25662130
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24428921
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.22914008
116Platelet activation_Homo sapiens_hsa046110.22721098
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22587519
118Histidine metabolism_Homo sapiens_hsa003400.19661434
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18208380
120Hedgehog signaling pathway_Homo sapiens_hsa043400.18178970

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