ELMOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.76315597
2regulation of female gonad development (GO:2000194)4.58865384
3female gonad development (GO:0008585)4.39836178
4meiotic chromosome segregation (GO:0045132)4.21362370
5DNA double-strand break processing (GO:0000729)4.21091961
6intraciliary transport (GO:0042073)3.91672884
7negative regulation of keratinocyte proliferation (GO:0010839)3.89410716
8chromatin remodeling at centromere (GO:0031055)3.88823659
9female gamete generation (GO:0007292)3.84537376
10CENP-A containing nucleosome assembly (GO:0034080)3.76891642
11DNA ligation (GO:0006266)3.72232175
12regulation of meiosis (GO:0040020)3.63806436
13glycerophospholipid catabolic process (GO:0046475)3.60003208
14DNA damage induced protein phosphorylation (GO:0006975)3.52936613
15protein K6-linked ubiquitination (GO:0085020)3.50789614
16sphingosine metabolic process (GO:0006670)3.48945813
17DNA methylation involved in gamete generation (GO:0043046)3.45541379
18mitotic metaphase plate congression (GO:0007080)3.42413465
19oocyte maturation (GO:0001556)3.41554528
20olfactory bulb development (GO:0021772)3.40994484
21replicative senescence (GO:0090399)3.39909260
22negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.38427567
23kinetochore organization (GO:0051383)3.38214415
24retinal ganglion cell axon guidance (GO:0031290)3.35061979
25male meiosis (GO:0007140)3.30812865
26meiotic cell cycle (GO:0051321)3.29629384
27histone H2A monoubiquitination (GO:0035518)3.28182445
28negative regulation of meiosis (GO:0045835)3.26135742
29negative regulation of hormone metabolic process (GO:0032351)3.24166517
30negative regulation of hormone biosynthetic process (GO:0032353)3.24166517
31DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.18771372
32regulation of exit from mitosis (GO:0007096)3.17452396
33nuclear pore organization (GO:0006999)3.17248634
34histone exchange (GO:0043486)3.16632633
35monoubiquitinated protein deubiquitination (GO:0035520)3.15665948
36myoblast migration (GO:0051451)3.15129447
37nuclear pore complex assembly (GO:0051292)3.14797886
38righting reflex (GO:0060013)3.13582704
39DNA replication-independent nucleosome organization (GO:0034724)3.12334793
40DNA replication-independent nucleosome assembly (GO:0006336)3.12334793
41cholesterol biosynthetic process (GO:0006695)3.09235920
42microtubule depolymerization (GO:0007019)3.09229963
43DNA damage response, signal transduction resulting in transcription (GO:0042772)3.08824374
44diol metabolic process (GO:0034311)3.05152211
45negative regulation of smooth muscle cell differentiation (GO:0051151)3.05145303
46axon extension involved in axon guidance (GO:0048846)3.05083654
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.05083654
48regulation of meiotic cell cycle (GO:0051445)3.04913729
49snRNA transcription (GO:0009301)3.04535663
50N-terminal protein amino acid acetylation (GO:0006474)3.04121105
51interkinetic nuclear migration (GO:0022027)3.03707003
52regulation of meiosis I (GO:0060631)3.03299506
53protein localization to kinetochore (GO:0034501)3.03101390
54centriole replication (GO:0007099)3.03007181
55histone H3-K4 trimethylation (GO:0080182)3.02880122
56paraxial mesoderm development (GO:0048339)3.01608708
57metaphase plate congression (GO:0051310)2.99569399
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.99012383
59non-recombinational repair (GO:0000726)2.97863875
60double-strand break repair via nonhomologous end joining (GO:0006303)2.97863875
61histone lysine demethylation (GO:0070076)2.96882023
62establishment of integrated proviral latency (GO:0075713)2.95453039
63centriole assembly (GO:0098534)2.95423052
64pyrimidine nucleobase catabolic process (GO:0006208)2.95117115
65negative regulation of homotypic cell-cell adhesion (GO:0034111)2.93799467
66regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93762975
67cytoplasmic mRNA processing body assembly (GO:0033962)2.93564097
68L-serine metabolic process (GO:0006563)2.92930124
69lens morphogenesis in camera-type eye (GO:0002089)2.92624702
70protein neddylation (GO:0045116)2.92174661
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92076886
72negative regulation of axon guidance (GO:1902668)2.87665429
73regulation of histone H3-K27 methylation (GO:0061085)2.86900938
74histone demethylation (GO:0016577)2.86225011
75regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86097542
76photoreceptor cell maintenance (GO:0045494)2.85996897
77limb bud formation (GO:0060174)2.85496060
78appendage development (GO:0048736)2.85429068
79limb development (GO:0060173)2.85429068
80sphingoid metabolic process (GO:0046519)2.84655970
81kinetochore assembly (GO:0051382)2.84045704
82positive regulation of interleukin-1 beta secretion (GO:0050718)2.83425215
83regulation of establishment of cell polarity (GO:2000114)2.83011969
84regulation of keratinocyte proliferation (GO:0010837)2.81922129
85histone H3-K36 demethylation (GO:0070544)2.81894835
86cullin deneddylation (GO:0010388)2.80654919
87response to pheromone (GO:0019236)2.80209329
88type B pancreatic cell development (GO:0003323)2.80115993
89regulation of centriole replication (GO:0046599)2.79461510
90presynaptic membrane assembly (GO:0097105)2.78087009
91sister chromatid cohesion (GO:0007062)2.77997257
92sterol biosynthetic process (GO:0016126)2.76309331
93regulation of acrosome reaction (GO:0060046)2.74463957
94regulation of mononuclear cell migration (GO:0071675)2.74245674
95positive regulation of cellular amide metabolic process (GO:0034250)2.73682988
96regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.72951618
97spindle checkpoint (GO:0031577)2.72307549
98cellular response to gamma radiation (GO:0071480)2.72057188
99positive regulation of DNA-dependent DNA replication (GO:2000105)2.71608249
100negative regulation of execution phase of apoptosis (GO:1900118)2.71431742
101ganglion development (GO:0061548)2.70649896
102mitotic sister chromatid cohesion (GO:0007064)2.70476891
103establishment of chromosome localization (GO:0051303)2.69899700
104epithelial cilium movement (GO:0003351)2.68976953
105poly(A)+ mRNA export from nucleus (GO:0016973)2.67992850
106protein-chromophore linkage (GO:0018298)2.66993518
107regulation of RIG-I signaling pathway (GO:0039535)2.66752327
108regulation of acyl-CoA biosynthetic process (GO:0050812)2.63733547
109regulation of DNA endoreduplication (GO:0032875)2.62581179
110mitotic G2/M transition checkpoint (GO:0044818)2.62334937
111replication fork processing (GO:0031297)2.62005196
112regulation of cofactor metabolic process (GO:0051193)2.61611880
113regulation of coenzyme metabolic process (GO:0051196)2.61611880
114dorsal/ventral axis specification (GO:0009950)2.61529876
115positive regulation of interleukin-1 secretion (GO:0050716)2.61226105
116nonmotile primary cilium assembly (GO:0035058)2.59051159
117mitotic spindle checkpoint (GO:0071174)2.58407510
118microtubule anchoring (GO:0034453)2.57619873
119regulation of mitotic spindle checkpoint (GO:1903504)2.57423277
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.57423277
121negative regulation of DNA recombination (GO:0045910)2.57014451
122multicellular organism reproduction (GO:0032504)2.56071479
123cilium morphogenesis (GO:0060271)2.55856096
124DNA strand renaturation (GO:0000733)2.55569270
125histone H2A ubiquitination (GO:0033522)2.54164749
126regulation of retinoic acid receptor signaling pathway (GO:0048385)2.53973964
127reciprocal DNA recombination (GO:0035825)2.53656802
128reciprocal meiotic recombination (GO:0007131)2.53656802
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50655009
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.50655009
131negative regulation of sister chromatid segregation (GO:0033046)2.50655009
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.50655009
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50655009
134G-protein coupled receptor internalization (GO:0002031)2.50019363
135DNA topological change (GO:0006265)2.49846983
136regulation of activation of Janus kinase activity (GO:0010533)2.49631637
137protein localization to microtubule cytoskeleton (GO:0072698)2.49550759
138positive regulation of interleukin-1 beta production (GO:0032731)2.49312795
139sister chromatid segregation (GO:0000819)2.48934097
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.48721214
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.48721214
142protein demethylation (GO:0006482)2.48038606
143protein dealkylation (GO:0008214)2.48038606
144presynaptic membrane organization (GO:0097090)2.48026833
145DNA methylation (GO:0006306)2.46997242
146DNA alkylation (GO:0006305)2.46997242
147lysine catabolic process (GO:0006554)2.46221372
148lysine metabolic process (GO:0006553)2.46221372
149branched-chain amino acid catabolic process (GO:0009083)2.46199581
150water-soluble vitamin biosynthetic process (GO:0042364)2.45872789
151mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.45683701
152positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.45683701
153regulation of transcription from RNA polymerase I promoter (GO:0006356)2.45512029
154positive regulation of meiosis (GO:0045836)2.45219812
155negative regulation of chromosome segregation (GO:0051985)2.44771586
156peptidyl-lysine trimethylation (GO:0018023)2.44578540
157negative regulation of alcohol biosynthetic process (GO:1902931)2.44518146
158protein prenylation (GO:0018342)2.44456106
159prenylation (GO:0097354)2.44456106
160DNA damage response, detection of DNA damage (GO:0042769)2.44133807
161eye photoreceptor cell differentiation (GO:0001754)2.43679555
162photoreceptor cell differentiation (GO:0046530)2.43679555
163histone H3-K4 methylation (GO:0051568)2.43314442
164DNA replication-dependent nucleosome assembly (GO:0006335)2.43075390
165DNA replication-dependent nucleosome organization (GO:0034723)2.43075390
166resolution of meiotic recombination intermediates (GO:0000712)2.42981397
167regulation of interleukin-1 beta secretion (GO:0050706)2.42618222
168organelle disassembly (GO:1903008)2.42599009
169mitotic chromosome condensation (GO:0007076)2.42028265
170positive regulation of meiotic cell cycle (GO:0051446)2.40516188
171somite development (GO:0061053)2.39995003
172protein deneddylation (GO:0000338)2.38967126
173spindle assembly checkpoint (GO:0071173)2.38626878
174mitotic spindle assembly checkpoint (GO:0007094)2.38075027
175ATP-dependent chromatin remodeling (GO:0043044)2.37701149
176regulation of mitotic sister chromatid separation (GO:0010965)2.36125740
177regulation of mitotic sister chromatid segregation (GO:0033047)2.36125740
178regulation of sister chromatid segregation (GO:0033045)2.36125740
179regulation of sulfur metabolic process (GO:0042762)2.35950767
180axonal fasciculation (GO:0007413)2.35898388
181regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35284507
182negative chemotaxis (GO:0050919)2.32435570
183regulation of development, heterochronic (GO:0040034)2.32099626
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30644239
185ribonucleoprotein complex disassembly (GO:0032988)2.30617679
186mitotic G2 DNA damage checkpoint (GO:0007095)2.30184004
187embryonic foregut morphogenesis (GO:0048617)2.30145061
188protein localization to chromosome, centromeric region (GO:0071459)2.30092067
189otic vesicle formation (GO:0030916)2.29867179
190cilium assembly (GO:0042384)2.28140743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.28629568
2GBX2_23144817_ChIP-Seq_PC3_Human3.20088086
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92781899
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.86791775
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85379292
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.83099803
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.80140766
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.66356377
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59379241
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57423541
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53623495
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44005818
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.43802473
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37274433
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33576281
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.32089658
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.24881969
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.20201426
19ELK1_19687146_ChIP-ChIP_HELA_Human2.20107926
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16023994
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14719915
22ZNF274_21170338_ChIP-Seq_K562_Hela2.14300967
23EZH2_27294783_Chip-Seq_NPCs_Mouse2.06549887
24KAP1_22055183_ChIP-Seq_ESCs_Mouse2.05475146
25NANOG_18555785_Chip-Seq_ESCs_Mouse2.04797229
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.00036509
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97707255
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97556747
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.96027270
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93870975
31IGF1R_20145208_ChIP-Seq_DFB_Human1.88668200
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.88254849
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86939020
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84904849
35AR_21909140_ChIP-Seq_LNCAP_Human1.84266445
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.81976089
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.79487917
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78836668
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.76790102
40E2F7_22180533_ChIP-Seq_HELA_Human1.76324467
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.75198397
42P53_22387025_ChIP-Seq_ESCs_Mouse1.74598440
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70806547
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70806547
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69979115
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.68959751
47VDR_22108803_ChIP-Seq_LS180_Human1.68339009
48EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.67790786
49P300_19829295_ChIP-Seq_ESCs_Human1.67321315
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.66345332
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65625622
52STAT3_23295773_ChIP-Seq_U87_Human1.64826325
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63267552
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.63232202
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62391098
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.61042445
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.60388713
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60317437
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.60049019
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.57653451
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55719463
62FUS_26573619_Chip-Seq_HEK293_Human1.55134531
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54882670
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52905504
65P300_18555785_Chip-Seq_ESCs_Mouse1.52606309
66ZFX_18555785_Chip-Seq_ESCs_Mouse1.52254522
67RNF2_27304074_Chip-Seq_NSC_Mouse1.51593732
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51261954
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50877146
70RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50736210
71SMAD4_21799915_ChIP-Seq_A2780_Human1.50067188
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.47976839
73EWS_26573619_Chip-Seq_HEK293_Human1.47897458
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47795658
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.47605404
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47258739
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.45809381
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.45629692
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.43247359
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42484588
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41823447
82PU1_27457419_Chip-Seq_LIVER_Mouse1.41232329
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.40509487
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37355447
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37141102
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36667629
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.35757132
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32023601
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.31749145
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31658093
91TCF4_23295773_ChIP-Seq_U87_Human1.30470731
92ER_23166858_ChIP-Seq_MCF-7_Human1.28816183
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28017618
94TBL1_22424771_ChIP-Seq_293T_Human1.27949453
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26902148
96TAF15_26573619_Chip-Seq_HEK293_Human1.26870664
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26424199
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.24823398
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24755403
100IRF1_19129219_ChIP-ChIP_H3396_Human1.24367982
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22984477
102AR_25329375_ChIP-Seq_VCAP_Human1.22238683
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20869566
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.20606880
105KDM2B_26808549_Chip-Seq_REH_Human1.20208786
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20175256
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18763303
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.17260435
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16225380
110STAT1_17558387_ChIP-Seq_HELA_Human1.15963703
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.15864305
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15851961
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14493427
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.14256841
115CDX2_22108803_ChIP-Seq_LS180_Human1.13956459
116VDR_23849224_ChIP-Seq_CD4+_Human1.13783014
117AR_21572438_ChIP-Seq_LNCaP_Human1.13770290
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13596035
119MYC_18940864_ChIP-ChIP_HL60_Human1.13565820
120RUNX2_22187159_ChIP-Seq_PCA_Human1.11773343
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11009237
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10975856
123EZH2_22144423_ChIP-Seq_EOC_Human1.09749646
124* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09111610
125ETV1_20927104_ChIP-Seq_GIST48_Human1.08554062
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08232511
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08119100
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07912601
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07584088
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.07485976
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07147345
132NFYA_21822215_ChIP-Seq_K562_Human1.07006696
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05561800
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05449035
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05344715
136CBP_20019798_ChIP-Seq_JUKART_Human1.05344715
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03005966
138* MYC_18555785_ChIP-Seq_MESCs_Mouse1.02693668
139MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02650269
140TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02454057
141ARNT_22903824_ChIP-Seq_MCF-7_Human1.01835749
142TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01533779
143TCF4_22108803_ChIP-Seq_LS180_Human0.99608607
144TP53_16413492_ChIP-PET_HCT116_Human0.99169774
145NFYB_21822215_ChIP-Seq_K562_Human0.98617880
146AHR_22903824_ChIP-Seq_MCF-7_Human0.97205446
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97168625
148GF1B_26923725_Chip-Seq_HPCs_Mouse0.97140157
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96929102
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95934767
151SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95414264
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95400947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.47258196
2MP0006292_abnormal_olfactory_placode4.43359942
3MP0000569_abnormal_digit_pigmentation3.64224990
4MP0005451_abnormal_body_composition3.41575488
5MP0003718_maternal_effect3.30007662
6MP0005646_abnormal_pituitary_gland3.24888413
7MP0001188_hyperpigmentation2.89178063
8MP0003122_maternal_imprinting2.83461227
9MP0003787_abnormal_imprinting2.71609213
10MP0000566_synostosis2.61817500
11MP0001293_anophthalmia2.37432260
12MP0003646_muscle_fatigue2.35775625
13MP0008260_abnormal_autophagy2.34350428
14MP0008877_abnormal_DNA_methylation2.27003673
15MP0006054_spinal_hemorrhage2.21931990
16MP0000579_abnormal_nail_morphology2.16320293
17MP0003941_abnormal_skin_development2.16240398
18MP0005551_abnormal_eye_electrophysiolog2.09722389
19MP0000015_abnormal_ear_pigmentation2.09052142
20MP0001119_abnormal_female_reproductive2.03047722
21MP0003880_abnormal_central_pattern2.02698218
22MP0009697_abnormal_copulation2.01478186
23MP0010030_abnormal_orbit_morphology2.00164935
24MP0002638_abnormal_pupillary_reflex1.99248977
25MP0003567_abnormal_fetal_cardiomyocyte1.98992870
26MP0001986_abnormal_taste_sensitivity1.89021277
27MP0003937_abnormal_limbs/digits/tail_de1.83457671
28MP0008057_abnormal_DNA_replication1.78889653
29MP0000516_abnormal_urinary_system1.77938088
30MP0005367_renal/urinary_system_phenotyp1.77938088
31MP0005395_other_phenotype1.77919339
32MP0008058_abnormal_DNA_repair1.77376478
33MP0005394_taste/olfaction_phenotype1.72157268
34MP0005499_abnormal_olfactory_system1.72157268
35MP0005408_hypopigmentation1.72000458
36MP0000383_abnormal_hair_follicle1.71735808
37MP0003136_yellow_coat_color1.70531424
38MP0000778_abnormal_nervous_system1.68833687
39MP0003699_abnormal_female_reproductive1.68640864
40MP0010094_abnormal_chromosome_stability1.67852932
41MP0008932_abnormal_embryonic_tissue1.62626392
42MP0002697_abnormal_eye_size1.62585929
43MP0003111_abnormal_nucleus_morphology1.61566825
44MP0006072_abnormal_retinal_apoptosis1.60324095
45MP0005171_absent_coat_pigmentation1.56642283
46MP0004957_abnormal_blastocyst_morpholog1.50233389
47MP0002751_abnormal_autonomic_nervous1.49212353
48MP0002277_abnormal_respiratory_mucosa1.48525562
49MP0001346_abnormal_lacrimal_gland1.46744030
50MP0002249_abnormal_larynx_morphology1.44397095
51MP0004133_heterotaxia1.42820569
52MP0003385_abnormal_body_wall1.42782580
53MP0000427_abnormal_hair_cycle1.42085406
54MP0001299_abnormal_eye_distance/1.41408384
55MP0003119_abnormal_digestive_system1.40464804
56MP0005253_abnormal_eye_physiology1.37693421
57MP0000372_irregular_coat_pigmentation1.34210009
58MP0000647_abnormal_sebaceous_gland1.33654663
59MP0005187_abnormal_penis_morphology1.32944134
60MP0006276_abnormal_autonomic_nervous1.32312264
61MP0002210_abnormal_sex_determination1.29933802
62MP0010386_abnormal_urinary_bladder1.29417354
63MP0001929_abnormal_gametogenesis1.28946110
64MP0005248_abnormal_Harderian_gland1.28633986
65MP0003950_abnormal_plasma_membrane1.28603638
66MP0001502_abnormal_circadian_rhythm1.28459919
67MP0005257_abnormal_intraocular_pressure1.26941419
68MP0000537_abnormal_urethra_morphology1.26851952
69MP0002234_abnormal_pharynx_morphology1.25822978
70MP0002177_abnormal_outer_ear1.25127616
71MP0002084_abnormal_developmental_patter1.23870680
72MP0005647_abnormal_sex_gland1.23763145
73MP0000653_abnormal_sex_gland1.22597061
74MP0005670_abnormal_white_adipose1.22318912
75MP0004782_abnormal_surfactant_physiolog1.20772203
76MP0003011_delayed_dark_adaptation1.20278919
77MP0000428_abnormal_craniofacial_morphol1.18584173
78MP0000049_abnormal_middle_ear1.18263588
79MP0005174_abnormal_tail_pigmentation1.17659565
80MP0002092_abnormal_eye_morphology1.17128410
81MP0003123_paternal_imprinting1.13569216
82MP0002282_abnormal_trachea_morphology1.13457619
83MP0000462_abnormal_digestive_system1.12161662
84MP0005195_abnormal_posterior_eye1.11614386
85MP0005423_abnormal_somatic_nervous1.11168577
86MP0003861_abnormal_nervous_system1.09548288
87MP0005379_endocrine/exocrine_gland_phen1.09233281
88MP0003121_genomic_imprinting1.08815243
89MP0002111_abnormal_tail_morphology1.08075430
90MP0003221_abnormal_cardiomyocyte_apopto1.07473810
91MP0004197_abnormal_fetal_growth/weight/1.07470002
92MP0008995_early_reproductive_senescence1.06868036
93MP0008007_abnormal_cellular_replicative1.06665370
94MP0005197_abnormal_uvea_morphology1.04233193
95MP0002090_abnormal_vision1.03863702
96MP0003077_abnormal_cell_cycle1.03561267
97MP0003693_abnormal_embryo_hatching1.03197221
98MP0002085_abnormal_embryonic_tissue1.00779630
99MP0002938_white_spotting1.00061053
100MP0004185_abnormal_adipocyte_glucose0.99764807
101MP0003755_abnormal_palate_morphology0.99206314
102MP0000026_abnormal_inner_ear0.97498464
103MP0001485_abnormal_pinna_reflex0.97432120
104MP0002876_abnormal_thyroid_physiology0.97417935
105MP0004381_abnormal_hair_follicle0.96858021
106MP0000631_abnormal_neuroendocrine_gland0.96225281
107MP0003942_abnormal_urinary_system0.95858987
108MP0008789_abnormal_olfactory_epithelium0.94940370
109MP0005380_embryogenesis_phenotype0.94198010
110MP0001672_abnormal_embryogenesis/_devel0.94198010
111MP0009250_abnormal_appendicular_skeleto0.92979333
112MP0002095_abnormal_skin_pigmentation0.92625026
113MP0000538_abnormal_urinary_bladder0.91523769
114MP0001697_abnormal_embryo_size0.90655235
115MP0001324_abnormal_eye_pigmentation0.90317029
116MP0010678_abnormal_skin_adnexa0.90106531
117MP0004215_abnormal_myocardial_fiber0.89815622
118MP0009053_abnormal_anal_canal0.89448038
119MP0001177_atelectasis0.87824361
120MP0001186_pigmentation_phenotype0.87806927
121MP0003195_calcinosis0.87288347
122MP0005085_abnormal_gallbladder_physiolo0.85163006
123MP0003890_abnormal_embryonic-extraembry0.85034313
124MP0001286_abnormal_eye_development0.84787064
125MP0002653_abnormal_ependyma_morphology0.84277168
126MP0002109_abnormal_limb_morphology0.84149917
127MP0004272_abnormal_basement_membrane0.83743362
128MP0009384_cardiac_valve_regurgitation0.82160730
129MP0004742_abnormal_vestibular_system0.82032391
130MP0009703_decreased_birth_body0.81278022
131MP0009115_abnormal_fat_cell0.80967180
132MP0003984_embryonic_growth_retardation0.79171001
133MP0000955_abnormal_spinal_cord0.78819223
134MP0002752_abnormal_somatic_nervous0.78452681
135MP0002088_abnormal_embryonic_growth/wei0.78079945
136MP0000678_abnormal_parathyroid_gland0.78026240
137MP0000432_abnormal_head_morphology0.77865201
138MP0002168_other_aberrant_phenotype0.76064621
139MP0002877_abnormal_melanocyte_morpholog0.75664731
140MP0002116_abnormal_craniofacial_bone0.75380957
141MP0002184_abnormal_innervation0.75342088
142MP0003938_abnormal_ear_development0.75318508
143MP0005310_abnormal_salivary_gland0.75131824
144MP0002822_catalepsy0.74796919
145MP0001145_abnormal_male_reproductive0.74323365
146MP0002928_abnormal_bile_duct0.73819300
147MP0005645_abnormal_hypothalamus_physiol0.73673941
148MP0003315_abnormal_perineum_morphology0.73499181
149MP0005391_vision/eye_phenotype0.73400879
150MP0000613_abnormal_salivary_gland0.72102309
151MP0001984_abnormal_olfaction0.72076510
152MP0002233_abnormal_nose_morphology0.71998702
153MP0001963_abnormal_hearing_physiology0.71213574
154MP0001529_abnormal_vocalization0.71160319
155MP0002075_abnormal_coat/hair_pigmentati0.70389112
156MP0003935_abnormal_craniofacial_develop0.69452121

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.54136477
2Chromsome breakage (HP:0040012)6.24651478
3Prostate neoplasm (HP:0100787)4.08172550
4Papillary thyroid carcinoma (HP:0002895)3.45738022
5Congenital stationary night blindness (HP:0007642)3.35267631
6Intestinal atresia (HP:0011100)3.29271133
7Abnormality of the fingertips (HP:0001211)3.15949445
8Hyperglycinemia (HP:0002154)3.11086151
9Abnormality of chromosome stability (HP:0003220)3.05162174
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.04851851
11Bifid tongue (HP:0010297)3.02078660
12Hepatoblastoma (HP:0002884)2.99752797
13Abnormality of the renal collecting system (HP:0004742)2.98292619
14Flat capital femoral epiphysis (HP:0003370)2.95211247
15Chorioretinal atrophy (HP:0000533)2.94942377
16Ectopic kidney (HP:0000086)2.90121895
17Medial flaring of the eyebrow (HP:0010747)2.89294374
18Duplicated collecting system (HP:0000081)2.88679533
19Male infertility (HP:0003251)2.87060407
20Aplasia/Hypoplasia of the fovea (HP:0008060)2.84489040
21Hypoplasia of the fovea (HP:0007750)2.84489040
22Genital tract atresia (HP:0001827)2.81679529
23Vaginal atresia (HP:0000148)2.81091927
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79566681
25Volvulus (HP:0002580)2.78848273
26Pancreatic fibrosis (HP:0100732)2.77746837
27Abnormal lung lobation (HP:0002101)2.76550124
28Congenital primary aphakia (HP:0007707)2.74857630
29Supernumerary spleens (HP:0009799)2.71253026
30Clubbing of toes (HP:0100760)2.68167408
31Capillary hemangiomas (HP:0005306)2.66789127
32Abnormality of the preputium (HP:0100587)2.65248014
33True hermaphroditism (HP:0010459)2.64847849
34Bony spicule pigmentary retinopathy (HP:0007737)2.64828299
35Gait imbalance (HP:0002141)2.62855678
36Colon cancer (HP:0003003)2.62378433
37Meckel diverticulum (HP:0002245)2.60886169
38Chronic hepatic failure (HP:0100626)2.58625392
39Retrobulbar optic neuritis (HP:0100654)2.56282474
40Optic neuritis (HP:0100653)2.56282474
41Abnormality of incisor morphology (HP:0011063)2.54605521
42Nephrogenic diabetes insipidus (HP:0009806)2.53204317
43Cortical dysplasia (HP:0002539)2.45789597
44Acute myeloid leukemia (HP:0004808)2.44391122
45Abnormality of the ileum (HP:0001549)2.41883078
46Decreased central vision (HP:0007663)2.39711215
47Lip pit (HP:0100267)2.39599642
48Abnormality of the fovea (HP:0000493)2.36991164
49Pendular nystagmus (HP:0012043)2.36928519
50Abnormality of the nasal septum (HP:0000419)2.35470591
51Abnormality of the carotid arteries (HP:0005344)2.30910558
52Abnormality of the prostate (HP:0008775)2.29907094
53Oligodactyly (hands) (HP:0001180)2.29598880
54Midline defect of the nose (HP:0004122)2.28910028
55Shawl scrotum (HP:0000049)2.28200369
56Pigmentary retinal degeneration (HP:0001146)2.27268061
57Renal hypoplasia (HP:0000089)2.26474038
58Febrile seizures (HP:0002373)2.19859405
59Pancreatic cysts (HP:0001737)2.19310288
60Patellar aplasia (HP:0006443)2.19094428
61Abnormality of serine family amino acid metabolism (HP:0010894)2.18341891
62Abnormality of glycine metabolism (HP:0010895)2.18341891
63Hypergonadotropic hypogonadism (HP:0000815)2.17934971
64Gastrointestinal atresia (HP:0002589)2.17739934
65Pancreatic islet-cell hyperplasia (HP:0004510)2.17655244
66Adrenal hypoplasia (HP:0000835)2.17654235
67Anophthalmia (HP:0000528)2.17449648
68Abnormality of the intervertebral disk (HP:0005108)2.16059881
69Postaxial hand polydactyly (HP:0001162)2.15543618
70Labial hypoplasia (HP:0000066)2.15116251
71Congenital sensorineural hearing impairment (HP:0008527)2.14359604
72Dyschromatopsia (HP:0007641)2.13387632
73Aplasia/Hypoplasia of the macula (HP:0008059)2.11718169
74Abnormality of the phalanges of the hallux (HP:0010057)2.09188491
75Broad foot (HP:0001769)2.09145042
76Abnormal rod and cone electroretinograms (HP:0008323)2.08839126
77Abnormal hair whorl (HP:0010721)2.08183644
78Renal cortical cysts (HP:0000803)2.06353873
79Tubulointerstitial nephritis (HP:0001970)2.04747095
80Insulin-resistant diabetes mellitus (HP:0000831)2.04244717
81Abnormality of macular pigmentation (HP:0008002)2.04106290
82Abnormality of DNA repair (HP:0003254)2.03875954
83Hypoplastic female external genitalia (HP:0012815)2.03163431
84Cone-rod dystrophy (HP:0000548)2.01337227
85Esophageal atresia (HP:0002032)1.95425913
86Abnormality of serum amino acid levels (HP:0003112)1.94141734
87Aplasia/Hypoplasia of the patella (HP:0006498)1.93544823
88Preaxial hand polydactyly (HP:0001177)1.92573101
89Aqueductal stenosis (HP:0002410)1.92449351
90Abnormality of chromosome segregation (HP:0002916)1.92280767
91Absent eyebrow (HP:0002223)1.90598795
92Abolished electroretinogram (ERG) (HP:0000550)1.88575241
93Stenosis of the external auditory canal (HP:0000402)1.88560501
94Hyperglycinuria (HP:0003108)1.88199887
95Septo-optic dysplasia (HP:0100842)1.87846131
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.87611745
97Nephroblastoma (Wilms tumor) (HP:0002667)1.87328497
98Absent radius (HP:0003974)1.86788424
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86726422
100Rhabdomyosarcoma (HP:0002859)1.86285294
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.86174467
102Short tibia (HP:0005736)1.85821156
103Azoospermia (HP:0000027)1.85696247
104Narrow forehead (HP:0000341)1.85492959
105Fair hair (HP:0002286)1.85166583
106Dandy-Walker malformation (HP:0001305)1.84310859
107Duodenal stenosis (HP:0100867)1.81915969
108Small intestinal stenosis (HP:0012848)1.81915969
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81771581
110Attenuation of retinal blood vessels (HP:0007843)1.81443951
111Male pseudohermaphroditism (HP:0000037)1.81217531
112Hypoplastic pelvis (HP:0008839)1.81015229
113Poor coordination (HP:0002370)1.80990633
114Congenital hepatic fibrosis (HP:0002612)1.80844473
115Abnormality of the duodenum (HP:0002246)1.79953285
116Increased serum pyruvate (HP:0003542)1.79675751
117Birth length less than 3rd percentile (HP:0003561)1.79312057
118Thyroid carcinoma (HP:0002890)1.79261712
119Keratoconus (HP:0000563)1.79108690
120Increased corneal curvature (HP:0100692)1.79108690
121Facial hemangioma (HP:0000329)1.78565496
122Drooling (HP:0002307)1.78369565
123Abnormality of midbrain morphology (HP:0002418)1.77974187
124Molar tooth sign on MRI (HP:0002419)1.77974187
125Median cleft lip (HP:0000161)1.77743657
126Neoplasm of the tracheobronchial system (HP:0100552)1.77668446
127Anencephaly (HP:0002323)1.76941847
128Abnormality of male internal genitalia (HP:0000022)1.76829412
129Medulloblastoma (HP:0002885)1.76587677
130Cutaneous finger syndactyly (HP:0010554)1.75645430
131Postaxial foot polydactyly (HP:0001830)1.74855757
132Impulsivity (HP:0100710)1.74392304
133Oligodactyly (HP:0012165)1.73924730
134Embryonal renal neoplasm (HP:0011794)1.73819868
135Decreased testicular size (HP:0008734)1.73818046
136Abnormality of the renal medulla (HP:0100957)1.72772345
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.72718137
138Increased nuchal translucency (HP:0010880)1.72670970
139Aplasia involving forearm bones (HP:0009822)1.72626074
140Absent forearm bone (HP:0003953)1.72626074
141Myelomeningocele (HP:0002475)1.72420671
142Abnormal respiratory motile cilium physiology (HP:0012261)1.71492751
143Abnormality of the labia minora (HP:0012880)1.71120451
144Hypoplastic labia majora (HP:0000059)1.70597813
145Occipital encephalocele (HP:0002085)1.70170960
146Oligohydramnios (HP:0001562)1.70141017
147Abnormal biliary tract morphology (HP:0012440)1.69418760
148Generalized hypopigmentation of hair (HP:0011358)1.69394948
149Cystic liver disease (HP:0006706)1.69202936
150Sclerocornea (HP:0000647)1.69121170
151Nephronophthisis (HP:0000090)1.68968732
152Abnormality of the renal cortex (HP:0011035)1.68740256
153Arterial tortuosity (HP:0005116)1.68285018
154Abnormality of methionine metabolism (HP:0010901)1.67823673
155Photophobia (HP:0000613)1.67481910
156Micropenis (HP:0000054)1.67111743
157Aplasia/hypoplasia of the humerus (HP:0006507)1.66804084
158Triphalangeal thumb (HP:0001199)1.66016750
159Intrahepatic cholestasis (HP:0001406)1.65340299
160Orchitis (HP:0100796)1.64769014
161Neoplasm of the adrenal gland (HP:0100631)1.64538676
162Vitreoretinal degeneration (HP:0000655)1.64263687
163Alveolar cell carcinoma (HP:0006519)1.63244989
164Methylmalonic acidemia (HP:0002912)1.62428960
165Sloping forehead (HP:0000340)1.62316464
166Astigmatism (HP:0000483)1.61298173
167Gonadotropin excess (HP:0000837)1.60233764
168Growth hormone deficiency (HP:0000824)1.58544316
169Cutaneous syndactyly (HP:0012725)1.58536080
170Specific learning disability (HP:0001328)1.58331843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.51666687
2WNK33.61928244
3BCR3.29616983
4ERBB43.07387161
5MAP3K63.01191224
6STK38L2.96529829
7TRIM282.90982362
8TAOK32.71485014
9PLK42.57085648
10MKNK12.48537707
11PBK2.46207738
12NUAK12.31750091
13MUSK2.26501966
14ZAK2.18996201
15WEE12.11388812
16LATS22.09682758
17NEK12.03009291
18INSRR2.01513445
19EIF2AK32.01079881
20SGK21.96217386
21STK31.96047561
22TTK1.85838094
23CDK91.78916487
24CDK31.78001305
25EPHA41.74573369
26MAPK131.69907502
27EIF2AK21.62747821
28FRK1.62277461
29BRSK21.60869219
30PNCK1.59002850
31TAF11.50494601
32MAP4K21.50490985
33CAMK1D1.50405886
34STK161.50237051
35BUB11.49294877
36MAP3K131.49167301
37ACVR1B1.43912275
38SRPK11.40339488
39SGK4941.37228095
40SGK2231.37228095
41CDK81.35689190
42EPHA31.34022778
43EIF2AK11.30827903
44BMPR21.30085224
45TSSK61.29918985
46DYRK21.29238718
47GRK11.29210416
48IRAK31.26647756
49PRKAA21.24785232
50CASK1.24405074
51CHEK21.24027922
52CDC71.22784054
53BRD41.22248061
54VRK11.18970643
55EPHB21.13168555
56SGK31.12435060
57CSNK1G21.12113746
58MAP3K141.09778850
59FGFR11.04689046
60MST41.03507974
61NLK1.02939201
62MELK1.02767340
63DYRK31.02072204
64BMPR1B1.00452619
65CAMK1G1.00381993
66NEK60.97826588
67CSNK1G30.97211951
68CDK120.95920535
69TXK0.93817083
70MAP2K70.93299287
71BRAF0.93120947
72PRKAA10.92506640
73STK390.90141609
74CHUK0.89956579
75MKNK20.88537446
76PRKD30.87053914
77JAK30.86277893
78BCKDK0.85640175
79IRAK40.84206114
80PRKD20.82170832
81YES10.81853743
82AKT30.81351092
83RPS6KA40.80224783
84JAK10.79923895
85NEK90.78140746
86BRSK10.77863115
87MINK10.76904874
88PLK30.76816403
89CCNB10.75991571
90ATM0.75293600
91IKBKE0.74483690
92PLK10.74228907
93STK240.70890463
94DMPK0.70363248
95TRPM70.69411752
96ATR0.69066013
97STK380.68350430
98TGFBR10.67887048
99DYRK1B0.65269065
100KIT0.64559750
101PIK3CA0.63168586
102PRKCE0.61191348
103CDK60.60525939
104TNIK0.59947957
105CSNK1G10.59776152
106FGFR30.59770211
107NTRK20.56549126
108ABL10.54936070
109PRPF4B0.54373847
110MARK10.53638406
111PINK10.53299931
112SGK10.52685288
113WNK40.51935628
114PKN10.51783101
115SIK30.51725868
116ERBB20.51094507
117TEC0.50835688
118PRKCG0.50255950
119ADRBK20.49040352
120MAP2K40.48093673
121CSNK1A1L0.47115366
122FER0.46257905
123AKT10.45928947
124DYRK1A0.45369634
125TYK20.44989626
126IRAK20.44574727
127MAP3K50.43518477
128NEK20.42670842
129CSNK1E0.41766132
130HIPK20.41754495
131PAK30.41164441
132ERBB30.40682547
133AURKB0.40446286
134CDK10.40098811
135FGFR20.38712760
136MAP3K100.38404200
137PDK20.38141193
138MARK20.36879531
139CSNK2A10.36797371
140MAPK100.36771874
141UHMK10.36644000
142CDK140.36180006
143MAP3K40.35636457
144CDK180.35623511
145IRAK10.35319617
146CHEK10.35268066
147MAPK140.33684645
148KSR10.33337713
149PLK20.33199887
150FLT30.33005318
151MAPK110.32693971
152CSNK2A20.31790562
153PRKACB0.31668704
154PRKDC0.31556942

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.20069623
2Protein export_Homo sapiens_hsa030603.01248316
3Fanconi anemia pathway_Homo sapiens_hsa034602.89241442
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.75440142
5Phototransduction_Homo sapiens_hsa047442.73818505
6Circadian rhythm_Homo sapiens_hsa047102.47466217
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27728754
8Ovarian steroidogenesis_Homo sapiens_hsa049132.25838963
9Vitamin B6 metabolism_Homo sapiens_hsa007502.21047680
10Non-homologous end-joining_Homo sapiens_hsa034502.15847451
11Basal transcription factors_Homo sapiens_hsa030222.15498875
12Mismatch repair_Homo sapiens_hsa034301.92350615
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87063364
14Cell cycle_Homo sapiens_hsa041101.85860587
15Ether lipid metabolism_Homo sapiens_hsa005651.73635929
16Butanoate metabolism_Homo sapiens_hsa006501.71106749
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71018538
18Lysine degradation_Homo sapiens_hsa003101.70543781
19Pyruvate metabolism_Homo sapiens_hsa006201.67884276
20Homologous recombination_Homo sapiens_hsa034401.67187723
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66662090
22Sphingolipid metabolism_Homo sapiens_hsa006001.66609508
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62111805
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58743021
25Linoleic acid metabolism_Homo sapiens_hsa005911.54162916
26RNA degradation_Homo sapiens_hsa030181.51564588
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.50151330
28Fatty acid elongation_Homo sapiens_hsa000621.47562246
29RNA transport_Homo sapiens_hsa030131.46778792
30Fatty acid metabolism_Homo sapiens_hsa012121.46644523
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44391928
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41198644
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.39721855
34Spliceosome_Homo sapiens_hsa030401.33427967
35Pancreatic cancer_Homo sapiens_hsa052121.30359515
36Hedgehog signaling pathway_Homo sapiens_hsa043401.29910299
37Basal cell carcinoma_Homo sapiens_hsa052171.27942734
38Peroxisome_Homo sapiens_hsa041461.20230117
39Nucleotide excision repair_Homo sapiens_hsa034201.19479349
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17414595
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16196086
42Vitamin digestion and absorption_Homo sapiens_hsa049771.13725202
43DNA replication_Homo sapiens_hsa030301.13046466
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12738421
45TGF-beta signaling pathway_Homo sapiens_hsa043501.12568640
46Fatty acid degradation_Homo sapiens_hsa000711.11927206
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11640265
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08400781
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08056771
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07850683
51ABC transporters_Homo sapiens_hsa020101.06279268
52Proteasome_Homo sapiens_hsa030501.06279025
53Herpes simplex infection_Homo sapiens_hsa051681.06004711
54Inositol phosphate metabolism_Homo sapiens_hsa005621.05801238
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.04310074
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03391661
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.02066187
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01598305
59Dorso-ventral axis formation_Homo sapiens_hsa043201.01552531
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.01406868
61MicroRNAs in cancer_Homo sapiens_hsa052061.00036607
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99358457
63Glutathione metabolism_Homo sapiens_hsa004800.98004185
64TNF signaling pathway_Homo sapiens_hsa046680.96623219
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95886345
66Other glycan degradation_Homo sapiens_hsa005110.94327455
67Influenza A_Homo sapiens_hsa051640.93623832
68Hippo signaling pathway_Homo sapiens_hsa043900.92045896
69Carbon metabolism_Homo sapiens_hsa012000.91929524
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91889414
71Choline metabolism in cancer_Homo sapiens_hsa052310.91861720
72Fat digestion and absorption_Homo sapiens_hsa049750.90414701
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90287784
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.90112848
75FoxO signaling pathway_Homo sapiens_hsa040680.90041856
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89091939
77Oxidative phosphorylation_Homo sapiens_hsa001900.88731855
78Prolactin signaling pathway_Homo sapiens_hsa049170.87918310
79Arachidonic acid metabolism_Homo sapiens_hsa005900.86949243
80Caffeine metabolism_Homo sapiens_hsa002320.86484150
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.85522121
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.84988058
83Huntingtons disease_Homo sapiens_hsa050160.84974415
84Retinol metabolism_Homo sapiens_hsa008300.84931757
85Prostate cancer_Homo sapiens_hsa052150.84646342
86Parkinsons disease_Homo sapiens_hsa050120.82461725
87p53 signaling pathway_Homo sapiens_hsa041150.81692535
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80778299
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79933882
90N-Glycan biosynthesis_Homo sapiens_hsa005100.79372767
91Autoimmune thyroid disease_Homo sapiens_hsa053200.79068749
92Small cell lung cancer_Homo sapiens_hsa052220.78992289
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77623565
94Measles_Homo sapiens_hsa051620.77424554
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77225592
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76794225
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76599512
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76536764
99Selenocompound metabolism_Homo sapiens_hsa004500.76365792
100Arginine and proline metabolism_Homo sapiens_hsa003300.75409973
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74378274
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73773524
103Chemical carcinogenesis_Homo sapiens_hsa052040.72236244
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71782868
105Axon guidance_Homo sapiens_hsa043600.71639526
106Biosynthesis of amino acids_Homo sapiens_hsa012300.71100360
107Oocyte meiosis_Homo sapiens_hsa041140.70373796
108Wnt signaling pathway_Homo sapiens_hsa043100.70003391
109Steroid biosynthesis_Homo sapiens_hsa001000.67859728
110Metabolic pathways_Homo sapiens_hsa011000.66642087
111Tryptophan metabolism_Homo sapiens_hsa003800.66284163
112Adherens junction_Homo sapiens_hsa045200.66255961
113Starch and sucrose metabolism_Homo sapiens_hsa005000.66216432
114Folate biosynthesis_Homo sapiens_hsa007900.64975911
115Hepatitis B_Homo sapiens_hsa051610.64801631
116Regulation of autophagy_Homo sapiens_hsa041400.64178980
117Staphylococcus aureus infection_Homo sapiens_hsa051500.63826062
118Ras signaling pathway_Homo sapiens_hsa040140.62884882
119beta-Alanine metabolism_Homo sapiens_hsa004100.60796333
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60730521
121Malaria_Homo sapiens_hsa051440.60568979
122Hematopoietic cell lineage_Homo sapiens_hsa046400.60451360
123Colorectal cancer_Homo sapiens_hsa052100.60391249
124Endometrial cancer_Homo sapiens_hsa052130.59978369
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59438108
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59418268
127Nicotine addiction_Homo sapiens_hsa050330.58771061
128Serotonergic synapse_Homo sapiens_hsa047260.58113761
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58073490
130One carbon pool by folate_Homo sapiens_hsa006700.57869063
131Graft-versus-host disease_Homo sapiens_hsa053320.55276203
132GnRH signaling pathway_Homo sapiens_hsa049120.52889340
133Hepatitis C_Homo sapiens_hsa051600.52276548
134ErbB signaling pathway_Homo sapiens_hsa040120.51106687
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50141927
136Notch signaling pathway_Homo sapiens_hsa043300.49927516
137Pyrimidine metabolism_Homo sapiens_hsa002400.49782728
138Type II diabetes mellitus_Homo sapiens_hsa049300.49557920
139Chemokine signaling pathway_Homo sapiens_hsa040620.48384314
140Sulfur metabolism_Homo sapiens_hsa009200.48322404
141Base excision repair_Homo sapiens_hsa034100.46575237
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46231079
143Glutamatergic synapse_Homo sapiens_hsa047240.44323180
144Nitrogen metabolism_Homo sapiens_hsa009100.44278624
145RNA polymerase_Homo sapiens_hsa030200.43875859
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43839622
147cAMP signaling pathway_Homo sapiens_hsa040240.43807066
148Renal cell carcinoma_Homo sapiens_hsa052110.43621882
149Purine metabolism_Homo sapiens_hsa002300.43602531
150Rheumatoid arthritis_Homo sapiens_hsa053230.43397943
151mRNA surveillance pathway_Homo sapiens_hsa030150.43064495
152Taste transduction_Homo sapiens_hsa047420.42908303
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42299418
154Protein digestion and absorption_Homo sapiens_hsa049740.41645468
155Alcoholism_Homo sapiens_hsa050340.41511857
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.41109440
157Tight junction_Homo sapiens_hsa045300.40434739
158Histidine metabolism_Homo sapiens_hsa003400.39070498
159Melanoma_Homo sapiens_hsa052180.38859230
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.38566147
161Complement and coagulation cascades_Homo sapiens_hsa046100.38276993
162MAPK signaling pathway_Homo sapiens_hsa040100.36518166
163Alzheimers disease_Homo sapiens_hsa050100.36185987
164Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36152627
165Pathways in cancer_Homo sapiens_hsa052000.35233705
166Glycosaminoglycan degradation_Homo sapiens_hsa005310.34141434
167Morphine addiction_Homo sapiens_hsa050320.34015317
168Arginine biosynthesis_Homo sapiens_hsa002200.33433483
169Melanogenesis_Homo sapiens_hsa049160.31036872
170Fatty acid biosynthesis_Homo sapiens_hsa000610.30533308
171Renin-angiotensin system_Homo sapiens_hsa046140.29791409

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