ELMOD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the engulfment and cell motility family of GTPase-activating proteins that regulate Arf GTPase proteins. Members of this family are defined by a conserved engulfment and cell motility domain. In rat cochlea, the encoded protein is found in stereocilia, kinocilia and cuticular plate of developing hair cells suggesting a function for this protein in cochlear sensory cells. An allelic variant of this family has been associated with autosomal recessive nonsyndromic deafness-88 in humans. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)5.16345595
2sensory perception of smell (GO:0007608)4.79439750
3phosphorelay signal transduction system (GO:0000160)4.62038805
4sulfur amino acid catabolic process (GO:0000098)4.33751849
5low-density lipoprotein particle remodeling (GO:0034374)4.23692857
6detection of calcium ion (GO:0005513)3.94599022
7indolalkylamine metabolic process (GO:0006586)3.94037938
8fucose catabolic process (GO:0019317)3.92969938
9L-fucose metabolic process (GO:0042354)3.92969938
10L-fucose catabolic process (GO:0042355)3.92969938
11succinate metabolic process (GO:0006105)3.90224347
12piRNA metabolic process (GO:0034587)3.78905083
13behavioral response to nicotine (GO:0035095)3.73379084
14protein localization to cilium (GO:0061512)3.72113444
15oxaloacetate metabolic process (GO:0006107)3.67144371
16fructose metabolic process (GO:0006000)3.60077608
17cellular modified amino acid catabolic process (GO:0042219)3.55977463
18modulation by virus of host process (GO:0019054)3.53884706
19adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.52224140
20one-carbon compound transport (GO:0019755)3.49772574
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49180149
22alpha-linolenic acid metabolic process (GO:0036109)3.41973663
23reverse cholesterol transport (GO:0043691)3.41852641
24DNA deamination (GO:0045006)3.40964160
25amine catabolic process (GO:0009310)3.36313568
26cellular biogenic amine catabolic process (GO:0042402)3.36313568
27negative regulation of erythrocyte differentiation (GO:0045647)3.35892649
28carnitine metabolic process (GO:0009437)3.35186874
29L-phenylalanine catabolic process (GO:0006559)3.31361272
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.31361272
31negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.31289374
32fatty acid beta-oxidation (GO:0006635)3.29408321
33regulation of sequestering of triglyceride (GO:0010889)3.29356611
34plasma lipoprotein particle remodeling (GO:0034369)3.29170894
35protein-lipid complex remodeling (GO:0034368)3.29170894
36macromolecular complex remodeling (GO:0034367)3.29170894
37amino-acid betaine metabolic process (GO:0006577)3.27599822
38positive regulation of fatty acid beta-oxidation (GO:0032000)3.24959630
39aromatic amino acid family catabolic process (GO:0009074)3.24188012
40response to pheromone (GO:0019236)3.23336663
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.22661989
42short-chain fatty acid metabolic process (GO:0046459)3.22602711
43regulation of cholesterol esterification (GO:0010872)3.21172991
44tryptophan catabolic process (GO:0006569)3.20658779
45indole-containing compound catabolic process (GO:0042436)3.20658779
46indolalkylamine catabolic process (GO:0046218)3.20658779
47nonribosomal peptide biosynthetic process (GO:0019184)3.20454157
48branched-chain amino acid metabolic process (GO:0009081)3.20170233
49DNA methylation involved in gamete generation (GO:0043046)3.19993835
50ovulation cycle (GO:0042698)3.19532544
51lipid oxidation (GO:0034440)3.18934299
52lactate metabolic process (GO:0006089)3.17848368
532-oxoglutarate metabolic process (GO:0006103)3.16243127
54sensory perception of chemical stimulus (GO:0007606)3.14218785
55cytochrome complex assembly (GO:0017004)3.13386080
56regulation of triglyceride catabolic process (GO:0010896)3.12560940
57lysine metabolic process (GO:0006553)3.11341229
58lysine catabolic process (GO:0006554)3.11341229
59cellular response to virus (GO:0098586)3.10746103
60regulation of cilium movement (GO:0003352)3.10152902
61high-density lipoprotein particle remodeling (GO:0034375)3.08800896
62negative regulation of telomere maintenance (GO:0032205)3.08743689
63platelet dense granule organization (GO:0060155)3.08651311
64respiratory chain complex IV assembly (GO:0008535)3.07797033
65axoneme assembly (GO:0035082)3.05263797
66negative regulation of mast cell activation (GO:0033004)3.04767491
67atrial cardiac muscle cell action potential (GO:0086014)3.03809093
68tryptophan metabolic process (GO:0006568)3.02982193
69cellular glucuronidation (GO:0052695)3.02802792
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02676031
71fatty acid oxidation (GO:0019395)3.02141866
72preassembly of GPI anchor in ER membrane (GO:0016254)3.02133615
73cellular response to exogenous dsRNA (GO:0071360)3.01084961
74glutathione biosynthetic process (GO:0006750)3.00378467
75ADP metabolic process (GO:0046031)2.97257991
76positive regulation of fatty acid oxidation (GO:0046321)2.94859334
77positive regulation of defense response to virus by host (GO:0002230)2.92564520
78L-phenylalanine metabolic process (GO:0006558)2.92186046
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.92186046
80iron-sulfur cluster assembly (GO:0016226)2.90763999
81metallo-sulfur cluster assembly (GO:0031163)2.90763999
82cilium or flagellum-dependent cell motility (GO:0001539)2.90615103
83negative regulation of astrocyte differentiation (GO:0048712)2.89857482
84branched-chain amino acid catabolic process (GO:0009083)2.88469892
85cellular ketone body metabolic process (GO:0046950)2.88058419
86modulation by symbiont of host cellular process (GO:0044068)2.88010657
87protein insertion into membrane (GO:0051205)2.87979045
88homocysteine metabolic process (GO:0050667)2.87550887
89regulation of cholesterol metabolic process (GO:0090181)2.87400524
90fatty acid catabolic process (GO:0009062)2.87291484
91detection of light stimulus involved in sensory perception (GO:0050962)2.81876549
92detection of light stimulus involved in visual perception (GO:0050908)2.81876549
93cysteine metabolic process (GO:0006534)2.81398307
94flavonoid metabolic process (GO:0009812)2.80222842
95venous blood vessel morphogenesis (GO:0048845)2.79844688
96indole-containing compound metabolic process (GO:0042430)2.79773477
97negative regulation of lipase activity (GO:0060192)2.77860580
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77640601
99regulation of memory T cell differentiation (GO:0043380)2.77347515
100monocarboxylic acid catabolic process (GO:0072329)2.75542115
101ethanol oxidation (GO:0006069)2.74219238
102artery smooth muscle contraction (GO:0014824)2.73957616
103hormone catabolic process (GO:0042447)2.73130580
104alanine transport (GO:0032328)2.72839917
105tricarboxylic acid cycle (GO:0006099)2.72523952
106regulation of fatty acid beta-oxidation (GO:0031998)2.71999561
107cellular amino acid catabolic process (GO:0009063)2.71390449
108glucuronate metabolic process (GO:0019585)2.71210306
109uronic acid metabolic process (GO:0006063)2.71210306
110ketone body metabolic process (GO:1902224)2.69311162
111plasma lipoprotein particle organization (GO:0071827)2.67601487
112kynurenine metabolic process (GO:0070189)2.67263185
113cholesterol efflux (GO:0033344)2.67086018
114glyoxylate metabolic process (GO:0046487)2.66666510
115alpha-amino acid catabolic process (GO:1901606)2.65826540
116linoleic acid metabolic process (GO:0043651)2.65551030
117phospholipid homeostasis (GO:0055091)2.65335676
118tyrosine phosphorylation of STAT protein (GO:0007260)2.65254756
119intraciliary transport (GO:0042073)2.64480072
120rRNA catabolic process (GO:0016075)2.64464935
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64193002
122phospholipid efflux (GO:0033700)2.63577472
123tricarboxylic acid metabolic process (GO:0072350)2.63167861
124epithelial cilium movement (GO:0003351)2.62844322
125positive regulation of lipid catabolic process (GO:0050996)2.61717515
126NADH metabolic process (GO:0006734)2.60991302
127gamma-aminobutyric acid transport (GO:0015812)2.55859208
128cAMP catabolic process (GO:0006198)2.52738484
129glycerol metabolic process (GO:0006071)2.51487662
130protein complex biogenesis (GO:0070271)2.49848463
131protein-cofactor linkage (GO:0018065)2.47760693
132mannosylation (GO:0097502)2.47609221
133S-adenosylmethionine metabolic process (GO:0046500)2.44203495
134sulfation (GO:0051923)2.42843456
135neural tube formation (GO:0001841)2.39425261
136regulation of triglyceride biosynthetic process (GO:0010866)2.38528400
137multicellular organism reproduction (GO:0032504)2.38467787
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38379962
139regulation of germinal center formation (GO:0002634)2.37414223
140negative regulation of Rho protein signal transduction (GO:0035024)2.36311761
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35997712
142ubiquinone biosynthetic process (GO:0006744)2.34854234
143negative regulation of cAMP-mediated signaling (GO:0043951)2.34684508
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.34322221
145water-soluble vitamin biosynthetic process (GO:0042364)2.32552067
146cellular response to ATP (GO:0071318)2.32409154
147regulation of hexokinase activity (GO:1903299)2.32014924
148regulation of glucokinase activity (GO:0033131)2.32014924
149behavioral response to ethanol (GO:0048149)2.31851099
150neurotransmitter metabolic process (GO:0042133)2.31609511
151photoreceptor cell maintenance (GO:0045494)2.30139331
152aromatic amino acid family metabolic process (GO:0009072)2.28200775
153sphingoid metabolic process (GO:0046519)2.27537898
154regulation of action potential (GO:0098900)2.26505599
155primary amino compound metabolic process (GO:1901160)2.24896869
156positive regulation of glycolytic process (GO:0045821)2.24483692
157negative regulation of interleukin-1 production (GO:0032692)2.23627236
158cilium morphogenesis (GO:0060271)2.22830809
159positive regulation of fatty acid transport (GO:2000193)2.22201175
160mitochondrial respiratory chain complex assembly (GO:0033108)2.19475572
161cyclic nucleotide catabolic process (GO:0009214)2.18887360
162cilium movement (GO:0003341)2.18390831
163cell wall macromolecule catabolic process (GO:0016998)2.16941176
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.16713853
165NADH dehydrogenase complex assembly (GO:0010257)2.16713853
166mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.16713853
167adaptation of signaling pathway (GO:0023058)2.15343531
168pyrimidine dimer repair (GO:0006290)2.15246891
169neurotransmitter biosynthetic process (GO:0042136)2.14659478
170negative regulation of protein autophosphorylation (GO:0031953)2.14080513
171regulation of defense response to virus by host (GO:0050691)2.13835699
172neuronal action potential (GO:0019228)2.13705711
173cornea development in camera-type eye (GO:0061303)2.12479978
174negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.12479626
175NAD biosynthetic process (GO:0009435)2.12423255
176arginine catabolic process (GO:0006527)2.12138827
177interferon-gamma production (GO:0032609)2.11116743
178benzene-containing compound metabolic process (GO:0042537)2.11034770
179alditol metabolic process (GO:0019400)2.10935010
180positive regulation of prostaglandin secretion (GO:0032308)2.10854305
181protein polyglutamylation (GO:0018095)2.10833827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.88228282
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.87134480
3EZH2_22144423_ChIP-Seq_EOC_Human3.42443089
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.34772957
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07287227
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.04745144
7IGF1R_20145208_ChIP-Seq_DFB_Human2.93659152
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.85827511
9VDR_22108803_ChIP-Seq_LS180_Human2.83602081
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.70739674
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.69249936
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.55545205
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46193085
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.41637324
15GBX2_23144817_ChIP-Seq_PC3_Human2.36329477
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.29777796
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18357535
18* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15617943
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96715635
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91860012
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82293713
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74753705
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70723712
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69354465
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66839289
26DROSHA_22980978_ChIP-Seq_HELA_Human1.63442991
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59137133
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57629005
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55868824
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51125879
31HTT_18923047_ChIP-ChIP_STHdh_Human1.48468591
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48298317
33GATA3_21878914_ChIP-Seq_MCF-7_Human1.47670350
34TP53_22573176_ChIP-Seq_HFKS_Human1.45384481
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43596838
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42571110
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41785775
38STAT3_23295773_ChIP-Seq_U87_Human1.40446640
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34069581
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.34069581
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30832455
42TCF4_23295773_ChIP-Seq_U87_Human1.29977238
43ERA_21632823_ChIP-Seq_H3396_Human1.29014957
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.28364832
45FUS_26573619_Chip-Seq_HEK293_Human1.28177610
46NCOR_22424771_ChIP-Seq_293T_Human1.25873988
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25454725
48AR_21572438_ChIP-Seq_LNCaP_Human1.23101698
49* AR_25329375_ChIP-Seq_VCAP_Human1.21922184
50GATA3_26560356_Chip-Seq_TH2_Human1.21805488
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21598849
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19754443
53AR_20517297_ChIP-Seq_VCAP_Human1.19298016
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.18625513
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18616568
56NANOG_19829295_ChIP-Seq_ESCs_Human1.18561010
57SOX2_19829295_ChIP-Seq_ESCs_Human1.18561010
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18345528
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.18178278
60HOXB7_26014856_ChIP-Seq_BT474_Human1.17963080
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.17854191
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.16879103
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14441622
64MYC_19829295_ChIP-Seq_ESCs_Human1.13610843
65TAF15_26573619_Chip-Seq_HEK293_Human1.13310705
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13291623
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12934019
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.12768432
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12067241
70SMAD4_21799915_ChIP-Seq_A2780_Human1.11588686
71TCF4_22108803_ChIP-Seq_LS180_Human1.11279170
72EWS_26573619_Chip-Seq_HEK293_Human1.11186970
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10737370
74P300_19829295_ChIP-Seq_ESCs_Human1.09680243
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09225011
76TAF2_19829295_ChIP-Seq_ESCs_Human1.08714647
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07865782
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07459728
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07329292
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06499429
81NANOG_20526341_ChIP-Seq_ESCs_Human1.05899907
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04167488
83RAC3_21632823_ChIP-Seq_H3396_Human1.04091737
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04002243
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.03196644
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02244653
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01970936
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01709611
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01052148
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01027635
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00893601
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.00096667
93AHR_22903824_ChIP-Seq_MCF-7_Human0.99581020
94RUNX2_22187159_ChIP-Seq_PCA_Human0.99445076
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.99352732
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99268575
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99237512
98IRF1_19129219_ChIP-ChIP_H3396_Human0.98355765
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98349726
100RXR_22108803_ChIP-Seq_LS180_Human0.98098953
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.98013149
102CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97899421
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97554548
104REST_21632747_ChIP-Seq_MESCs_Mouse0.97448620
105FOXA2_19822575_ChIP-Seq_HepG2_Human0.97267296
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96500478
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96012687
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95812291
109FOXH1_21741376_ChIP-Seq_ESCs_Human0.95706059
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94169547
111SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92856453
112SRF_21415370_ChIP-Seq_HL-1_Mouse0.92393645
113STAT1_20625510_ChIP-Seq_HELA_Human0.92333559
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92121906
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91870303
116SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90620663
117SMRT_27268052_Chip-Seq_Bcells_Human0.90387443
118FOXH1_21741376_ChIP-Seq_EPCs_Human0.89594420
119REST_18959480_ChIP-ChIP_MESCs_Mouse0.89467988
120ZFX_18555785_Chip-Seq_ESCs_Mouse0.87956947
121TAL1_26923725_Chip-Seq_HPCs_Mouse0.87545827
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87252740
123SOX2_18555785_Chip-Seq_ESCs_Mouse0.86584513
124OCT4_20526341_ChIP-Seq_ESCs_Human0.86182787
125STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85871468
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85091544
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85091544
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.83703258
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83367979
130RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83030523
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82844151
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.82756738
133P300_18555785_Chip-Seq_ESCs_Mouse0.82086207
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81556726
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.81030061
136ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80796970
137RUNX_20019798_ChIP-Seq_JUKART_Human0.80462967
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.80291412
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80286823
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80277400
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80165785
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80082818
143P53_22387025_ChIP-Seq_ESCs_Mouse0.79716459
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79158192
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78719991
146EZH2_27294783_Chip-Seq_ESCs_Mouse0.78706106
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78470598
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78343937
149* CTCF_20526341_ChIP-Seq_ESCs_Human0.78290937
150NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78186250
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.77902095
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77625001
153ER_23166858_ChIP-Seq_MCF-7_Human0.77540000
154RNF2_27304074_Chip-Seq_ESCs_Mouse0.75997178
155EED_16625203_ChIP-ChIP_MESCs_Mouse0.75238233
156* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75199207
157PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75151890
158CBP_20019798_ChIP-Seq_JUKART_Human0.74833693
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74833693
160EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.74549044
161BCAT_22108803_ChIP-Seq_LS180_Human0.74499412
162ESRRB_18555785_Chip-Seq_ESCs_Mouse0.74345226
163EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74275664
164RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74275664
165CDX2_22108803_ChIP-Seq_LS180_Human0.74191162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction5.66576271
2MP0005360_urolithiasis4.77851282
3MP0005670_abnormal_white_adipose4.51547397
4MP0002139_abnormal_hepatobiliary_system3.98199314
5MP0005365_abnormal_bile_salt3.51416808
6MP0005377_hearing/vestibular/ear_phenot3.50009240
7MP0003878_abnormal_ear_physiology3.50009240
8MP0002837_dystrophic_cardiac_calcinosis3.04139807
9MP0008875_abnormal_xenobiotic_pharmacok2.95407225
10MP0003806_abnormal_nucleotide_metabolis2.75953898
11MP0002822_catalepsy2.56906238
12MP0005085_abnormal_gallbladder_physiolo2.56431451
13MP0003724_increased_susceptibility_to2.52348035
14MP0002102_abnormal_ear_morphology2.41757368
15MP0008789_abnormal_olfactory_epithelium2.30686449
16MP0005646_abnormal_pituitary_gland2.29609585
17MP0003690_abnormal_glial_cell2.29004331
18MP0003011_delayed_dark_adaptation2.28597757
19MP0004147_increased_porphyrin_level2.21570897
20MP0002254_reproductive_system_inflammat2.21460719
21MP0005499_abnormal_olfactory_system2.20626437
22MP0005394_taste/olfaction_phenotype2.20626437
23MP0010329_abnormal_lipoprotein_level2.17742875
24MP0005645_abnormal_hypothalamus_physiol2.17177547
25MP0009697_abnormal_copulation2.04024761
26MP0005332_abnormal_amino_acid2.00780904
27MP0003252_abnormal_bile_duct1.81750255
28MP0009764_decreased_sensitivity_to1.74236682
29MP0001968_abnormal_touch/_nociception1.73876216
30MP0005171_absent_coat_pigmentation1.71973380
31MP0002638_abnormal_pupillary_reflex1.65173881
32MP0004043_abnormal_pH_regulation1.64283114
33MP0002138_abnormal_hepatobiliary_system1.62924158
34MP0008877_abnormal_DNA_methylation1.62479097
35MP0005167_abnormal_blood-brain_barrier1.60517220
36MP0005084_abnormal_gallbladder_morpholo1.60295081
37MP0005410_abnormal_fertilization1.56295632
38MP0002971_abnormal_brown_adipose1.54035283
39MP0005551_abnormal_eye_electrophysiolog1.52554183
40MP0006276_abnormal_autonomic_nervous1.46420446
41MP0002876_abnormal_thyroid_physiology1.45858861
42MP0008872_abnormal_physiological_respon1.45703764
43MP0006036_abnormal_mitochondrial_physio1.43665834
44MP0005584_abnormal_enzyme/coenzyme_acti1.43477814
45MP0005253_abnormal_eye_physiology1.36448097
46MP0001502_abnormal_circadian_rhythm1.34676281
47MP0001764_abnormal_homeostasis1.34074089
48MP0001485_abnormal_pinna_reflex1.34010499
49MP0002118_abnormal_lipid_homeostasis1.32657450
50MP0005666_abnormal_adipose_tissue1.31657937
51MP0000566_synostosis1.31490799
52MP0003656_abnormal_erythrocyte_physiolo1.31040591
53MP0000427_abnormal_hair_cycle1.30238709
54MP0005075_abnormal_melanosome_morpholog1.27672162
55MP0005448_abnormal_energy_balance1.25582237
56MP0003787_abnormal_imprinting1.24930847
57MP0003186_abnormal_redox_activity1.24668111
58MP0000569_abnormal_digit_pigmentation1.22789779
59MP0003075_altered_response_to1.21684207
60MP0001486_abnormal_startle_reflex1.19818096
61MP0000230_abnormal_systemic_arterial1.19425993
62MP0005083_abnormal_biliary_tract1.18521571
63MP0000372_irregular_coat_pigmentation1.18507928
64MP0003195_calcinosis1.18135298
65MP0002277_abnormal_respiratory_mucosa1.17064508
66MP0009046_muscle_twitch1.16394569
67MP0004130_abnormal_muscle_cell1.15784148
68MP0001542_abnormal_bone_strength1.15772196
69MP0004142_abnormal_muscle_tone1.15655505
70MP0001800_abnormal_humoral_immune1.14725750
71MP0005174_abnormal_tail_pigmentation1.10237816
72MP0002160_abnormal_reproductive_system1.08571399
73MP0005671_abnormal_response_to1.08493833
74MP0001666_abnormal_nutrient_absorption1.07349140
75MP0005535_abnormal_body_temperature1.06745160
76MP0005334_abnormal_fat_pad1.06422424
77MP0001790_abnormal_immune_system1.05533286
78MP0005387_immune_system_phenotype1.05533286
79MP0002148_abnormal_hypersensitivity_rea1.05161926
80MP0001835_abnormal_antigen_presentation1.05070616
81MP0001853_heart_inflammation1.02123174
82MP0004858_abnormal_nervous_system1.01833443
83MP0005166_decreased_susceptibility_to1.00272748
84MP0003646_muscle_fatigue0.99824467
85MP0005386_behavior/neurological_phenoty0.99680020
86MP0004924_abnormal_behavior0.99680020
87MP0006035_abnormal_mitochondrial_morpho0.99187351
88MP0002928_abnormal_bile_duct0.98973756
89MP0000609_abnormal_liver_physiology0.98899082
90MP0002736_abnormal_nociception_after0.97703212
91MP0005379_endocrine/exocrine_gland_phen0.97372831
92MP0008775_abnormal_heart_ventricle0.97340639
93MP0000013_abnormal_adipose_tissue0.96774131
94MP0001905_abnormal_dopamine_level0.93884864
95MP0009643_abnormal_urine_homeostasis0.93731392
96MP0006072_abnormal_retinal_apoptosis0.93644328
97MP0000685_abnormal_immune_system0.92973551
98MP0005319_abnormal_enzyme/_coenzyme0.91970348
99MP0002723_abnormal_immune_serum0.90929327
100MP0009785_altered_susceptibility_to0.90624470
101MP0002970_abnormal_white_adipose0.90584294
102MP0001963_abnormal_hearing_physiology0.89167507
103MP0002933_joint_inflammation0.89133431
104MP0004215_abnormal_myocardial_fiber0.88638068
105MP0001970_abnormal_pain_threshold0.86491418
106MP0003436_decreased_susceptibility_to0.86066579
107MP0004145_abnormal_muscle_electrophysio0.85794156
108MP0009840_abnormal_foam_cell0.85770693
109MP0005647_abnormal_sex_gland0.85693462
110MP0003633_abnormal_nervous_system0.85621316
111MP0003959_abnormal_lean_body0.85359537
112MP0004019_abnormal_vitamin_homeostasis0.85123272
113MP0003136_yellow_coat_color0.84697394
114MP0002733_abnormal_thermal_nociception0.83562916
115MP0003191_abnormal_cellular_cholesterol0.82726440
116MP0005000_abnormal_immune_tolerance0.82467610
117MP0002693_abnormal_pancreas_physiology0.81736968
118MP0002452_abnormal_antigen_presenting0.81683339
119MP0004484_altered_response_of0.81624064
120MP0001661_extended_life_span0.79929512
121MP0002653_abnormal_ependyma_morphology0.77857826
122MP0002419_abnormal_innate_immunity0.77481455
123MP0005595_abnormal_vascular_smooth0.77251361
124MP0002229_neurodegeneration0.76927631
125MP0003631_nervous_system_phenotype0.75944824
126MP0004381_abnormal_hair_follicle0.75819456
127MP0005636_abnormal_mineral_homeostasis0.75531919
128MP0002909_abnormal_adrenal_gland0.74855229
129MP0003868_abnormal_feces_composition0.74243508
130MP0005375_adipose_tissue_phenotype0.72306631
131MP0001501_abnormal_sleep_pattern0.71901012
132MP0004885_abnormal_endolymph0.70503240
133MP0001324_abnormal_eye_pigmentation0.69710846
134MP0004134_abnormal_chest_morphology0.69509047
135MP0003953_abnormal_hormone_level0.68463695
136MP0002572_abnormal_emotion/affect_behav0.67716919
137MP0009745_abnormal_behavioral_response0.67481025
138MP0003279_aneurysm0.66576594
139MP0005389_reproductive_system_phenotype0.65979142
140MP0008874_decreased_physiological_sensi0.65473238
141MP0005376_homeostasis/metabolism_phenot0.65058865
142MP0002132_abnormal_respiratory_system0.64779586
143MP0005058_abnormal_lysosome_morphology0.64380592
144MP0006292_abnormal_olfactory_placode0.63516900
145MP0002272_abnormal_nervous_system0.62612221
146MP0002078_abnormal_glucose_homeostasis0.62493500
147MP0002557_abnormal_social/conspecific_i0.61474155
148MP0004036_abnormal_muscle_relaxation0.59984723
149MP0009115_abnormal_fat_cell0.59498769
150MP0009780_abnormal_chondrocyte_physiolo0.58948193
151MP0004883_abnormal_blood_vessel0.58238906
152MP0000026_abnormal_inner_ear0.58077273
153MP0009642_abnormal_blood_homeostasis0.57157862
154MP0003183_abnormal_peptide_metabolism0.55550293
155MP0000604_amyloidosis0.55023256
156MP0002063_abnormal_learning/memory/cond0.54793722
157MP0003137_abnormal_impulse_conducting0.53562722
158MP0001986_abnormal_taste_sensitivity0.52419499

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.54613247
2Pancreatic cysts (HP:0001737)4.47197880
3Hyperglycinuria (HP:0003108)3.93580307
4Abnormality of the renal cortex (HP:0011035)3.77479880
5Molar tooth sign on MRI (HP:0002419)3.75610063
6Abnormality of midbrain morphology (HP:0002418)3.75610063
7Aplasia involving bones of the extremities (HP:0009825)3.63040616
8Aplasia involving bones of the upper limbs (HP:0009823)3.63040616
9Aplasia of the phalanges of the hand (HP:0009802)3.63040616
10Type II lissencephaly (HP:0007260)3.62241233
11Nephronophthisis (HP:0000090)3.56659486
12True hermaphroditism (HP:0010459)3.45988512
13Methylmalonic acidemia (HP:0002912)3.40333877
14Abnormality of serine family amino acid metabolism (HP:0010894)3.35022280
15Abnormality of glycine metabolism (HP:0010895)3.35022280
16Abnormality of the renal medulla (HP:0100957)3.20571508
17Medial flaring of the eyebrow (HP:0010747)3.15826802
18Abnormal respiratory motile cilium physiology (HP:0012261)3.13413671
19Hyperglycinemia (HP:0002154)3.10847369
20Attenuation of retinal blood vessels (HP:0007843)3.10155106
21Congenital primary aphakia (HP:0007707)3.02795491
22Abnormal hair whorl (HP:0010721)3.02646440
23Ketosis (HP:0001946)3.01786276
24Gait imbalance (HP:0002141)3.01306418
25Nephrogenic diabetes insipidus (HP:0009806)2.99897452
26Hypoplastic left heart (HP:0004383)2.98055812
27Chronic hepatic failure (HP:0100626)2.97624420
28Abnormality of sulfur amino acid metabolism (HP:0004339)2.95197813
29Hyperlipoproteinemia (HP:0010980)2.90927549
30Hyperventilation (HP:0002883)2.90667504
31Rhinitis (HP:0012384)2.90076372
32Ketoacidosis (HP:0001993)2.88588618
33Abnormal ciliary motility (HP:0012262)2.88575555
34Methylmalonic aciduria (HP:0012120)2.86199705
35Inability to walk (HP:0002540)2.83395993
36Abnormality of fatty-acid metabolism (HP:0004359)2.83067762
37Abnormality of methionine metabolism (HP:0010901)2.80981046
38Hyperammonemia (HP:0001987)2.80437428
39Dicarboxylic aciduria (HP:0003215)2.80117968
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80117968
41Abnormal respiratory epithelium morphology (HP:0012253)2.76875778
42Abnormal respiratory motile cilium morphology (HP:0005938)2.76875778
43Meningioma (HP:0002858)2.75614410
44Cystic liver disease (HP:0006706)2.75505766
45Abnormal drinking behavior (HP:0030082)2.72262730
46Polydipsia (HP:0001959)2.72262730
47Abnormality of homocysteine metabolism (HP:0010919)2.70964159
48Homocystinuria (HP:0002156)2.70964159
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68737412
50Palpitations (HP:0001962)2.68411131
51Hypoalphalipoproteinemia (HP:0003233)2.62164027
52Decreased central vision (HP:0007663)2.61139053
53Stomatitis (HP:0010280)2.60652361
54Stomach cancer (HP:0012126)2.60375610
55Xanthomatosis (HP:0000991)2.58485977
56Progressive inability to walk (HP:0002505)2.56814690
57Poor coordination (HP:0002370)2.56804421
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.55734396
59Polyphagia (HP:0002591)2.54960250
60Tubular atrophy (HP:0000092)2.52811031
61Central scotoma (HP:0000603)2.51664178
62Abnormality of macular pigmentation (HP:0008002)2.51312099
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50933687
64Intrahepatic cholestasis (HP:0001406)2.49760838
65Abolished electroretinogram (ERG) (HP:0000550)2.49719614
66Congenital hepatic fibrosis (HP:0002612)2.48399549
67Abnormality of alanine metabolism (HP:0010916)2.48335529
68Hyperalaninemia (HP:0003348)2.48335529
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48335529
70Abnormal rod and cone electroretinograms (HP:0008323)2.46811247
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46571244
72Myoglobinuria (HP:0002913)2.45747800
73Decreased circulating renin level (HP:0003351)2.43516319
74Alopecia of scalp (HP:0002293)2.42677463
75Bile duct proliferation (HP:0001408)2.37547901
76Abnormal biliary tract physiology (HP:0012439)2.37547901
77Abnormality of the vitamin B12 metabolism (HP:0004341)2.34691299
78Ragged-red muscle fibers (HP:0003200)2.30685156
79Hypoplastic heart (HP:0001961)2.29293307
80Generalized aminoaciduria (HP:0002909)2.29119495
81Large for gestational age (HP:0001520)2.29025293
82Hypoglycemic coma (HP:0001325)2.28520806
83Cerebellar dysplasia (HP:0007033)2.28020791
843-Methylglutaconic aciduria (HP:0003535)2.27772038
85Absent speech (HP:0001344)2.26635861
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24751711
87Joint hemorrhage (HP:0005261)2.24286500
88Renal cortical cysts (HP:0000803)2.24142253
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21754308
90Abnormal mitochondria in muscle tissue (HP:0008316)2.21271343
91Amelogenesis imperfecta (HP:0000705)2.19968309
92Gout (HP:0001997)2.19629537
93Oligomenorrhea (HP:0000876)2.19578772
94Abnormality of vitamin B metabolism (HP:0004340)2.18859005
95Metabolic acidosis (HP:0001942)2.17130507
96Left ventricular hypertrophy (HP:0001712)2.17074445
97Abnormality of vitamin metabolism (HP:0100508)2.15327765
98Prolonged partial thromboplastin time (HP:0003645)2.15204868
99Abnormality of serum amino acid levels (HP:0003112)2.13248053
100Abnormal urine output (HP:0012590)2.12753721
101Pancreatic fibrosis (HP:0100732)2.12223991
102Polyuria (HP:0000103)2.12197885
103Gaze-evoked nystagmus (HP:0000640)2.10648958
104Amyloidosis (HP:0011034)2.10509550
105Agitation (HP:0000713)2.10388178
106Lissencephaly (HP:0001339)2.09335184
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.07363283
108Absent/shortened dynein arms (HP:0200106)2.07363283
109Abnormality of purine metabolism (HP:0004352)2.05899969
110Pendular nystagmus (HP:0012043)2.05762214
111Myositis (HP:0100614)2.04848542
112Hyperuricemia (HP:0002149)2.04642829
113Increased purine levels (HP:0004368)2.04642829
114Retrobulbar optic neuritis (HP:0100654)2.04477684
115Optic neuritis (HP:0100653)2.04477684
116Anosmia (HP:0000458)2.03395444
117Increased corneal curvature (HP:0100692)2.03235377
118Keratoconus (HP:0000563)2.03235377
119Tubulointerstitial nephritis (HP:0001970)2.01989919
120Deep venous thrombosis (HP:0002625)2.01633064
121Potter facies (HP:0002009)2.01033501
122Facial shape deformation (HP:0011334)2.01033501
123Hypolipoproteinemia (HP:0010981)2.00070001
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99116771
125Constricted visual fields (HP:0001133)1.97962970
126Epileptic encephalopathy (HP:0200134)1.97705025
127Onycholysis (HP:0001806)1.97242034
128Median cleft lip (HP:0000161)1.96822302
129Complement deficiency (HP:0004431)1.95721195
130Hepatic necrosis (HP:0002605)1.95651827
131Elevated erythrocyte sedimentation rate (HP:0003565)1.94864203
132Severe visual impairment (HP:0001141)1.94658081
133Recurrent sinusitis (HP:0011108)1.94484393
134Febrile seizures (HP:0002373)1.94190086
135Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94031622
136Severe muscular hypotonia (HP:0006829)1.92919008
137Bony spicule pigmentary retinopathy (HP:0007737)1.92075532
138Occipital encephalocele (HP:0002085)1.90944497
139Retinitis pigmentosa (HP:0000510)1.90104876
140Aplasia/Hypoplasia of the lens (HP:0008063)1.87863754
141Increased muscle lipid content (HP:0009058)1.87597902
142Increased CSF lactate (HP:0002490)1.87454051
143Mitochondrial inheritance (HP:0001427)1.87251472
144Lethargy (HP:0001254)1.86532643
145Genetic anticipation (HP:0003743)1.86267229
146Acute encephalopathy (HP:0006846)1.86128719
147Vaginal atresia (HP:0000148)1.86035190
148Enlarged kidneys (HP:0000105)1.84819599
149Abnormality of proline metabolism (HP:0010907)1.84410297
150Hydroxyprolinuria (HP:0003080)1.84410297
151Retinal dysplasia (HP:0007973)1.83554950
152Tachypnea (HP:0002789)1.83110345
153Late onset (HP:0003584)1.82639716
154Cholecystitis (HP:0001082)1.82477988
155Abnormal gallbladder physiology (HP:0012438)1.82477988
156Genital tract atresia (HP:0001827)1.82115676
157Congenital stationary night blindness (HP:0007642)1.82036112
158Furrowed tongue (HP:0000221)1.81406535
159Macular degeneration (HP:0000608)1.81211783
160Clumsiness (HP:0002312)1.80865659
161Focal motor seizures (HP:0011153)1.80703018
162Protruding tongue (HP:0010808)1.79106910
163Follicular hyperkeratosis (HP:0007502)1.78576142
164Dialeptic seizures (HP:0011146)1.78533234
165Hematochezia (HP:0002573)1.78129326
166Congenital sensorineural hearing impairment (HP:0008527)1.77938332
167Abnormality of renal excretion (HP:0011036)1.76054017
168Hepatocellular necrosis (HP:0001404)1.76001658
169Tubulointerstitial abnormality (HP:0001969)1.75273758
170Orchitis (HP:0100796)1.73493457
171Broad-based gait (HP:0002136)1.70665173
172Pachygyria (HP:0001302)1.67566444
173Hemoptysis (HP:0002105)1.66904929
174Abnormality of dental color (HP:0011073)1.65804121
175Abnormal eating behavior (HP:0100738)1.65403281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.54212626
2RIPK15.38656767
3ARAF4.99496505
4PRPF4B4.05020675
5PIM23.11205262
6TAOK33.02318009
7MAP4K22.64088694
8ADRBK22.62317418
9MUSK2.54566776
10CASK2.53892499
11TNIK2.46515242
12ACVR1B2.24421590
13PHKG22.23182787
14PHKG12.23182787
15BRAF2.21336569
16STK242.11613477
17PDK32.01947253
18PDK42.01947253
19MAPK152.00877927
20SGK21.98673838
21BCKDK1.81211097
22WNK31.80354863
23AKT31.76557759
24INSRR1.74526724
25STK38L1.74044480
26CAMKK21.62377273
27TAOK21.62377207
28WNK41.59053342
29TLK11.49523181
30TRIB31.40471783
31SGK4941.39223369
32SGK2231.39223369
33KIT1.37340134
34ADRBK11.33020612
35ERN11.31932409
36MKNK21.31129974
37PIK3CG1.27357242
38LMTK21.27067349
39BLK1.25850791
40SGK31.23987105
41LATS11.20422223
42MAP2K71.19475517
43PINK11.15179417
44IKBKB1.14720137
45PDK21.12050203
46PAK31.11714618
47OXSR11.11659401
48SIK11.11426562
49TEC1.04630881
50MAPK121.01898082
51JAK30.97717649
52FES0.96575597
53MAPK110.96281163
54ICK0.95068941
55RAF10.92695696
56TRIM280.92243892
57GRK10.90532462
58MAP2K20.89195428
59GRK60.89149698
60MAP3K140.88816101
61TYK20.88778114
62STK160.87584952
63STK380.86464690
64PRKD30.84701939
65MAP3K40.83662866
66CAMK2G0.82046204
67GRK70.80485197
68ITK0.79484427
69MARK10.79329500
70CDK30.78709282
71MAPK130.78259508
72MAPKAPK30.77835227
73MAP2K60.76935196
74FLT30.76754040
75IKBKE0.76600279
76TGFBR10.76075685
77PDPK10.75153969
78NLK0.74666722
79STK390.74146437
80RPS6KB10.73440152
81MAP3K30.72749616
82BTK0.72480933
83PDK10.72365049
84RPS6KA20.71992871
85EPHA30.71846158
86ERBB40.69871388
87CAMK10.69766030
88MAP3K110.69490581
89LYN0.68546057
90IRAK30.67957687
91PRKCE0.65090613
92ERBB30.64137082
93SIK30.63385981
94MAPK70.63360418
95PRKCG0.63235827
96PKN10.61822064
97TBK10.60304036
98CSNK1G30.59564666
99SIK20.59290995
100MAP3K50.58822915
101MAP2K30.57729961
102CSNK1G20.57622615
103PRKCI0.56987606
104LCK0.56396874
105PLK20.56070938
106HCK0.55872035
107PTK2B0.55321995
108TIE10.54839795
109MST1R0.53993354
110CAMKK10.52752050
111TNK20.52528536
112CSNK1A1L0.51806784
113CAMK2D0.51173207
114PRKCQ0.51104371
115NTRK20.50943182
116ABL10.50699213
117CCNB10.50324395
118TXK0.49924747
119DYRK20.49497429
120CSF1R0.49377162
121PRKD20.48868660
122FER0.48249331
123MAP2K40.47939969
124IRAK40.47622363
125CSNK1G10.47316591
126PRKAA10.47275458
127SYK0.47221931
128PRKD10.46823503
129PRKACA0.46057657
130NUAK10.43747616
131MAPK40.43448228
132ZAP700.43367027
133PRKCZ0.43281816
134JAK20.42239651
135MARK30.42221031
136MAP4K10.41674346
137PRKCH0.41019155
138TGFBR20.40495030
139JAK10.40049529
140BMPR1B0.39952488
141MYLK0.39017854
142RPS6KC10.38566681
143RPS6KL10.38566681
144EPHA40.38286940
145MAP3K70.38257261
146MAP3K130.37265948
147BMPR20.36203764
148GRK50.36197997
149CAMK2B0.35688757
150ZAK0.33639652
151FGR0.32777799
152RPS6KA60.30506295
153DAPK20.30322755
154PRKAA20.30217074
155OBSCN0.30004879
156DDR20.28884511
157IGF1R0.28815903

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.25683707
2Olfactory transduction_Homo sapiens_hsa047403.09391280
3Fatty acid degradation_Homo sapiens_hsa000713.00120804
4Pyruvate metabolism_Homo sapiens_hsa006202.59336846
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46013982
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41544505
7Nitrogen metabolism_Homo sapiens_hsa009102.33032198
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.28387307
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28287760
10Fatty acid metabolism_Homo sapiens_hsa012122.26802888
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26702788
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20767461
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20027402
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.18597317
15beta-Alanine metabolism_Homo sapiens_hsa004102.18588091
16PPAR signaling pathway_Homo sapiens_hsa033202.17595068
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11540816
18Linoleic acid metabolism_Homo sapiens_hsa005912.10625734
19Fatty acid biosynthesis_Homo sapiens_hsa000612.05164333
20Peroxisome_Homo sapiens_hsa041462.01550029
21Asthma_Homo sapiens_hsa053101.94312211
22Butanoate metabolism_Homo sapiens_hsa006501.88262127
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85709652
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83304188
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.81273315
26Tryptophan metabolism_Homo sapiens_hsa003801.80139452
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73058638
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72150647
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71240453
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69912612
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63368633
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61638431
33Caffeine metabolism_Homo sapiens_hsa002321.61081100
34Graft-versus-host disease_Homo sapiens_hsa053321.60443993
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56384465
36Allograft rejection_Homo sapiens_hsa053301.56277940
37Chemical carcinogenesis_Homo sapiens_hsa052041.55816553
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53927848
39Sulfur metabolism_Homo sapiens_hsa009201.53070253
40Carbon metabolism_Homo sapiens_hsa012001.50482512
41Autoimmune thyroid disease_Homo sapiens_hsa053201.47390934
42Type I diabetes mellitus_Homo sapiens_hsa049401.47039887
43Bile secretion_Homo sapiens_hsa049761.41740559
44ABC transporters_Homo sapiens_hsa020101.40669218
45Ether lipid metabolism_Homo sapiens_hsa005651.38331524
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34204144
47Arginine biosynthesis_Homo sapiens_hsa002201.33988360
48Complement and coagulation cascades_Homo sapiens_hsa046101.32720685
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32443933
50Fatty acid elongation_Homo sapiens_hsa000621.27061000
51Starch and sucrose metabolism_Homo sapiens_hsa005001.24851041
52Histidine metabolism_Homo sapiens_hsa003401.24381123
53Nicotine addiction_Homo sapiens_hsa050331.23491513
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18412169
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17573602
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.16376161
57GABAergic synapse_Homo sapiens_hsa047271.16363803
58Ovarian steroidogenesis_Homo sapiens_hsa049131.15602562
59Fructose and mannose metabolism_Homo sapiens_hsa000511.13311845
60Arginine and proline metabolism_Homo sapiens_hsa003301.13100918
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08680517
62Biosynthesis of amino acids_Homo sapiens_hsa012301.07275704
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.06858273
64Morphine addiction_Homo sapiens_hsa050321.06730348
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.05766305
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05571406
67Oxidative phosphorylation_Homo sapiens_hsa001901.05138165
68Arachidonic acid metabolism_Homo sapiens_hsa005901.03705651
69Phenylalanine metabolism_Homo sapiens_hsa003601.02505373
70Insulin secretion_Homo sapiens_hsa049111.02347258
71Collecting duct acid secretion_Homo sapiens_hsa049660.99455883
72Phototransduction_Homo sapiens_hsa047440.97825225
73Circadian entrainment_Homo sapiens_hsa047130.95377822
74Primary immunodeficiency_Homo sapiens_hsa053400.95089078
75Rheumatoid arthritis_Homo sapiens_hsa053230.94650775
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.94492777
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.91081998
78Sulfur relay system_Homo sapiens_hsa041220.86372467
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84158793
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.82785000
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81776059
82Retinol metabolism_Homo sapiens_hsa008300.81020594
83Tyrosine metabolism_Homo sapiens_hsa003500.79689769
84Glycerolipid metabolism_Homo sapiens_hsa005610.74715508
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73925792
86Vitamin digestion and absorption_Homo sapiens_hsa049770.73323600
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72424981
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71833253
89Fanconi anemia pathway_Homo sapiens_hsa034600.71689510
90Homologous recombination_Homo sapiens_hsa034400.71342997
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70709418
92Steroid biosynthesis_Homo sapiens_hsa001000.69777198
93Dorso-ventral axis formation_Homo sapiens_hsa043200.69447585
94Hematopoietic cell lineage_Homo sapiens_hsa046400.64625592
95Pentose phosphate pathway_Homo sapiens_hsa000300.63186536
96Selenocompound metabolism_Homo sapiens_hsa004500.62662171
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57191976
98Fat digestion and absorption_Homo sapiens_hsa049750.57094687
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56550769
100Glutamatergic synapse_Homo sapiens_hsa047240.56423958
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56289678
102Parkinsons disease_Homo sapiens_hsa050120.56251619
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.55083228
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53989436
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52422015
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.51683100
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51023723
108Glutathione metabolism_Homo sapiens_hsa004800.50490000
109Staphylococcus aureus infection_Homo sapiens_hsa051500.49848590
110Galactose metabolism_Homo sapiens_hsa000520.49721351
111African trypanosomiasis_Homo sapiens_hsa051430.49207734
112Mineral absorption_Homo sapiens_hsa049780.47712998
113Vitamin B6 metabolism_Homo sapiens_hsa007500.47570767
114Taste transduction_Homo sapiens_hsa047420.46537777
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.46317207
116Basal transcription factors_Homo sapiens_hsa030220.45280772
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45262249
118Lysosome_Homo sapiens_hsa041420.44943109
119Metabolic pathways_Homo sapiens_hsa011000.44487094
120Glucagon signaling pathway_Homo sapiens_hsa049220.43583624
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43244615
122Sphingolipid metabolism_Homo sapiens_hsa006000.42692054
123Tuberculosis_Homo sapiens_hsa051520.39538757
124Other glycan degradation_Homo sapiens_hsa005110.38011780
125Cholinergic synapse_Homo sapiens_hsa047250.34250094
126Calcium signaling pathway_Homo sapiens_hsa040200.31906781
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.31643861
128Serotonergic synapse_Homo sapiens_hsa047260.30192278
129Lysine degradation_Homo sapiens_hsa003100.28049548
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26529622
131Renin secretion_Homo sapiens_hsa049240.26223905
132Synaptic vesicle cycle_Homo sapiens_hsa047210.25936944
133Salivary secretion_Homo sapiens_hsa049700.25285396
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22986210
135Regulation of autophagy_Homo sapiens_hsa041400.21346402
136Hepatitis C_Homo sapiens_hsa051600.21003321
137cAMP signaling pathway_Homo sapiens_hsa040240.18880431
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17153175
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15356009
140Insulin resistance_Homo sapiens_hsa049310.14433552
141Circadian rhythm_Homo sapiens_hsa047100.14067438
142Dopaminergic synapse_Homo sapiens_hsa047280.13165395
143Alzheimers disease_Homo sapiens_hsa050100.12976799

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