

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.59250705 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.01265161 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.83329189 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.43011842 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 4.43011842 |
| 6 | protein targeting to mitochondrion (GO:0006626) | 4.41879847 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.40162558 |
| 8 | regulation of mitochondrial translation (GO:0070129) | 4.18622946 |
| 9 | establishment of protein localization to mitochondrion (GO:0072655) | 4.15828918 |
| 10 | protein localization to mitochondrion (GO:0070585) | 3.97390755 |
| 11 | proteasome assembly (GO:0043248) | 3.93991363 |
| 12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.92027067 |
| 13 | establishment of viral latency (GO:0019043) | 3.89596736 |
| 14 | establishment of integrated proviral latency (GO:0075713) | 3.85052903 |
| 15 | pseudouridine synthesis (GO:0001522) | 3.81743478 |
| 16 | purine nucleobase biosynthetic process (GO:0009113) | 3.80118894 |
| 17 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.79007417 |
| 18 | respiratory electron transport chain (GO:0022904) | 3.78442403 |
| 19 | mitotic metaphase plate congression (GO:0007080) | 3.77881351 |
| 20 | axonemal dynein complex assembly (GO:0070286) | 3.77578807 |
| 21 | binding of sperm to zona pellucida (GO:0007339) | 3.73713179 |
| 22 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.72184688 |
| 23 | electron transport chain (GO:0022900) | 3.71492317 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69932967 |
| 25 | protein complex biogenesis (GO:0070271) | 3.68413525 |
| 26 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.68290251 |
| 27 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.67777435 |
| 28 | sperm-egg recognition (GO:0035036) | 3.66959683 |
| 29 | nucleobase biosynthetic process (GO:0046112) | 3.64596550 |
| 30 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.64497868 |
| 31 | GDP-mannose metabolic process (GO:0019673) | 3.64426497 |
| 32 | formation of translation preinitiation complex (GO:0001731) | 3.62227830 |
| 33 | DNA strand elongation (GO:0022616) | 3.62199337 |
| 34 | ribosomal small subunit assembly (GO:0000028) | 3.61499119 |
| 35 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.59133386 |
| 36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.57870518 |
| 37 | protein maturation by protein folding (GO:0022417) | 3.57523357 |
| 38 | ribosomal small subunit biogenesis (GO:0042274) | 3.54784651 |
| 39 | protein deneddylation (GO:0000338) | 3.53276362 |
| 40 | DNA replication checkpoint (GO:0000076) | 3.52459182 |
| 41 | rRNA modification (GO:0000154) | 3.49693347 |
| 42 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.46550611 |
| 43 | regulation of cilium movement (GO:0003352) | 3.44277142 |
| 44 | telomere maintenance via recombination (GO:0000722) | 3.41531467 |
| 45 | base-excision repair, AP site formation (GO:0006285) | 3.40939436 |
| 46 | negative regulation of ligase activity (GO:0051352) | 3.40902577 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.40902577 |
| 48 | sperm motility (GO:0030317) | 3.38536126 |
| 49 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.37277349 |
| 50 | respiratory chain complex IV assembly (GO:0008535) | 3.37141579 |
| 51 | cullin deneddylation (GO:0010388) | 3.36720862 |
| 52 | protein localization to chromosome, centromeric region (GO:0071459) | 3.34372270 |
| 53 | DNA replication initiation (GO:0006270) | 3.34037626 |
| 54 | fusion of sperm to egg plasma membrane (GO:0007342) | 3.32316041 |
| 55 | iron-sulfur cluster assembly (GO:0016226) | 3.32199118 |
| 56 | metallo-sulfur cluster assembly (GO:0031163) | 3.32199118 |
| 57 | protein neddylation (GO:0045116) | 3.31578923 |
| 58 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.31552048 |
| 59 | NADH dehydrogenase complex assembly (GO:0010257) | 3.31552048 |
| 60 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.31552048 |
| 61 | rRNA methylation (GO:0031167) | 3.31394200 |
| 62 | GTP biosynthetic process (GO:0006183) | 3.31109303 |
| 63 | chromatin remodeling at centromere (GO:0031055) | 3.30354233 |
| 64 | maturation of SSU-rRNA (GO:0030490) | 3.29049766 |
| 65 | 7-methylguanosine mRNA capping (GO:0006370) | 3.26921182 |
| 66 | CENP-A containing nucleosome assembly (GO:0034080) | 3.26510109 |
| 67 | piRNA metabolic process (GO:0034587) | 3.26428475 |
| 68 | motile cilium assembly (GO:0044458) | 3.26240356 |
| 69 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.25959977 |
| 70 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.24520466 |
| 71 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.24520466 |
| 72 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.24405187 |
| 73 | termination of RNA polymerase III transcription (GO:0006386) | 3.24405187 |
| 74 | cellular component biogenesis (GO:0044085) | 3.23845188 |
| 75 | spliceosomal snRNP assembly (GO:0000387) | 3.23157296 |
| 76 | positive regulation of cell cycle arrest (GO:0071158) | 3.22091929 |
| 77 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.19829697 |
| 78 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.19296424 |
| 79 | regulation of cellular amine metabolic process (GO:0033238) | 3.18884722 |
| 80 | cytochrome complex assembly (GO:0017004) | 3.18748062 |
| 81 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.17091520 |
| 82 | cell-cell recognition (GO:0009988) | 3.17058398 |
| 83 | histone exchange (GO:0043486) | 3.16887367 |
| 84 | DNA damage response, detection of DNA damage (GO:0042769) | 3.16619167 |
| 85 | UTP biosynthetic process (GO:0006228) | 3.16153431 |
| 86 | RNA capping (GO:0036260) | 3.15919655 |
| 87 | 7-methylguanosine RNA capping (GO:0009452) | 3.15919655 |
| 88 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.15759434 |
| 89 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.12079671 |
| 90 | positive regulation of ligase activity (GO:0051351) | 3.11418084 |
| 91 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.11180856 |
| 92 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.11180856 |
| 93 | negative regulation of protein ubiquitination (GO:0031397) | 3.10525647 |
| 94 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.09859528 |
| 95 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.09859528 |
| 96 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.09789608 |
| 97 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.09756617 |
| 98 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.09756617 |
| 99 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.09756617 |
| 100 | protein localization to kinetochore (GO:0034501) | 3.09451765 |
| 101 | viral transcription (GO:0019083) | 3.08608772 |
| 102 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.07964121 |
| 103 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.07072118 |
| 104 | ribosome biogenesis (GO:0042254) | 3.06633276 |
| 105 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.06145887 |
| 106 | spermatid development (GO:0007286) | 3.05334236 |
| 107 | mitotic recombination (GO:0006312) | 3.04990122 |
| 108 | peptidyl-histidine modification (GO:0018202) | 3.04496119 |
| 109 | metaphase plate congression (GO:0051310) | 3.04484471 |
| 110 | synaptonemal complex organization (GO:0070193) | 3.04409814 |
| 111 | synaptonemal complex assembly (GO:0007130) | 3.03290262 |
| 112 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.02855442 |
| 113 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.02002939 |
| 114 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.01582299 |
| 115 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.01582299 |
| 116 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.99731806 |
| 117 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.99669503 |
| 118 | L-serine metabolic process (GO:0006563) | 2.99043108 |
| 119 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.98870687 |
| 120 | ribosomal large subunit biogenesis (GO:0042273) | 2.98419968 |
| 121 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.98415489 |
| 122 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.97317078 |
| 123 | DNA replication-independent nucleosome organization (GO:0034724) | 2.93901829 |
| 124 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.93901829 |
| 125 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.91292363 |
| 126 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.90662145 |
| 127 | epithelial cilium movement (GO:0003351) | 2.89134686 |
| 128 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.88940958 |
| 129 | regulation of ligase activity (GO:0051340) | 2.88562729 |
| 130 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.88551716 |
| 131 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.86559220 |
| 132 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.86420303 |
| 133 | UTP metabolic process (GO:0046051) | 2.85169213 |
| 134 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.85099847 |
| 135 | establishment of chromosome localization (GO:0051303) | 2.85000514 |
| 136 | ribosome assembly (GO:0042255) | 2.84201249 |
| 137 | CTP biosynthetic process (GO:0006241) | 2.83172920 |
| 138 | CTP metabolic process (GO:0046036) | 2.83172920 |
| 139 | telomere maintenance via telomere lengthening (GO:0010833) | 2.83030947 |
| 140 | rRNA processing (GO:0006364) | 2.81976301 |
| 141 | cell cycle G1/S phase transition (GO:0044843) | 2.80859343 |
| 142 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.80859343 |
| 143 | multicellular organism reproduction (GO:0032504) | 2.80845712 |
| 144 | microtubule depolymerization (GO:0007019) | 2.80582048 |
| 145 | chromosome condensation (GO:0030261) | 2.80449974 |
| 146 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.79839219 |
| 147 | translation (GO:0006412) | 2.78380191 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.16389228 |
| 2 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 3.91446466 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.78357928 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.55180610 |
| 5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.54799905 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.54471961 |
| 7 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.41667019 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.23320670 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.07433480 |
| 10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.00476003 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.98808875 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.85753751 |
| 13 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.81967519 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.81613084 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60388271 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.47437049 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.38147581 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.35839788 |
| 19 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.33629952 |
| 20 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.28445476 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.22970127 |
| 22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.18559455 |
| 23 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.14912937 |
| 24 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.14117125 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.12387098 |
| 26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.06667980 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.00006942 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99043194 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.94860084 |
| 30 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.89525393 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.88820579 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.86531462 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.81437901 |
| 34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.76310030 |
| 35 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75638148 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.73554940 |
| 37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.69688079 |
| 38 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.67737488 |
| 39 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.66207733 |
| 40 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.65700912 |
| 41 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.64939425 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64858183 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.64593397 |
| 44 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.61935354 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.60021421 |
| 46 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.56962626 |
| 47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52639655 |
| 48 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.49201743 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45422240 |
| 50 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.42445471 |
| 51 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.42378891 |
| 52 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.41117297 |
| 53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41036953 |
| 54 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.36287404 |
| 55 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.33847753 |
| 56 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.33676512 |
| 57 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.29101508 |
| 58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.26493620 |
| 59 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.26088895 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25128982 |
| 61 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.22293748 |
| 62 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.22018131 |
| 63 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.21423764 |
| 64 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.20422778 |
| 65 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18909384 |
| 66 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.17011085 |
| 67 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.15800512 |
| 68 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.14030404 |
| 69 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.13882273 |
| 70 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.13496910 |
| 71 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.12131581 |
| 72 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.08718844 |
| 73 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.07436408 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06933223 |
| 75 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.05529144 |
| 76 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.04186816 |
| 77 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.03551378 |
| 78 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.03215771 |
| 79 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.01320125 |
| 80 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.01038934 |
| 81 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98369947 |
| 82 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.97766755 |
| 83 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.96614788 |
| 84 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.96217945 |
| 85 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95767992 |
| 86 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95446588 |
| 87 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.95191362 |
| 88 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.95155990 |
| 89 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.93868104 |
| 90 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93344648 |
| 91 | P68_20966046_ChIP-Seq_HELA_Human | 0.92229700 |
| 92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.91835786 |
| 93 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.91670142 |
| 94 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91168444 |
| 95 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.91055413 |
| 96 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90208545 |
| 97 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.88258727 |
| 98 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.88234777 |
| 99 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.88022701 |
| 100 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87567325 |
| 101 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.87063121 |
| 102 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.86955975 |
| 103 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.84201660 |
| 104 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.84019237 |
| 105 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.83693409 |
| 106 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.82217536 |
| 107 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.81945142 |
| 108 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.81052011 |
| 109 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80962899 |
| 110 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.80612320 |
| 111 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80110744 |
| 112 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.78856193 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.90882811 |
| 2 | MP0005410_abnormal_fertilization | 4.22682600 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.02487825 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.79187229 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.56942187 |
| 6 | MP0003077_abnormal_cell_cycle | 3.37386683 |
| 7 | MP0008058_abnormal_DNA_repair | 3.03692423 |
| 8 | MP0008877_abnormal_DNA_methylation | 2.86068502 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.59405536 |
| 10 | MP0001929_abnormal_gametogenesis | 2.54671975 |
| 11 | MP0003718_maternal_effect | 2.47388732 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.41750456 |
| 13 | MP0008057_abnormal_DNA_replication | 2.34548806 |
| 14 | MP0003786_premature_aging | 2.32823100 |
| 15 | MP0004147_increased_porphyrin_level | 2.21851023 |
| 16 | MP0005083_abnormal_biliary_tract | 2.20600831 |
| 17 | MP0005499_abnormal_olfactory_system | 2.18674198 |
| 18 | MP0005394_taste/olfaction_phenotype | 2.18674198 |
| 19 | MP0002210_abnormal_sex_determination | 2.06601776 |
| 20 | MP0001529_abnormal_vocalization | 2.02470952 |
| 21 | MP0002653_abnormal_ependyma_morphology | 1.97715075 |
| 22 | MP0003698_abnormal_male_reproductive | 1.93326556 |
| 23 | MP0003186_abnormal_redox_activity | 1.93252253 |
| 24 | MP0002132_abnormal_respiratory_system | 1.88744104 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.80202961 |
| 26 | MP0001730_embryonic_growth_arrest | 1.76567289 |
| 27 | MP0003123_paternal_imprinting | 1.75661151 |
| 28 | MP0001145_abnormal_male_reproductive | 1.73619607 |
| 29 | MP0002160_abnormal_reproductive_system | 1.68913057 |
| 30 | MP0009333_abnormal_splenocyte_physiolog | 1.68704954 |
| 31 | MP0003011_delayed_dark_adaptation | 1.62012569 |
| 32 | MP0000653_abnormal_sex_gland | 1.60466822 |
| 33 | MP0008260_abnormal_autophagy | 1.57752934 |
| 34 | MP0003806_abnormal_nucleotide_metabolis | 1.56446663 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.55788098 |
| 36 | MP0002736_abnormal_nociception_after | 1.52722538 |
| 37 | MP0001905_abnormal_dopamine_level | 1.51651860 |
| 38 | MP0000350_abnormal_cell_proliferation | 1.50408205 |
| 39 | MP0000490_abnormal_crypts_of | 1.47523398 |
| 40 | MP0003646_muscle_fatigue | 1.40836528 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.36020588 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.36020588 |
| 43 | MP0002161_abnormal_fertility/fecundity | 1.35143316 |
| 44 | MP0005389_reproductive_system_phenotype | 1.33160023 |
| 45 | MP0005501_abnormal_skin_physiology | 1.32814619 |
| 46 | MP0000313_abnormal_cell_death | 1.32402203 |
| 47 | MP0000358_abnormal_cell_content/ | 1.30819143 |
| 48 | MP0002019_abnormal_tumor_incidence | 1.30446636 |
| 49 | MP0004142_abnormal_muscle_tone | 1.29346561 |
| 50 | MP0005075_abnormal_melanosome_morpholog | 1.25897332 |
| 51 | MP0010307_abnormal_tumor_latency | 1.20126284 |
| 52 | MP0002080_prenatal_lethality | 1.19805013 |
| 53 | MP0001697_abnormal_embryo_size | 1.17636560 |
| 54 | MP0006054_spinal_hemorrhage | 1.12770008 |
| 55 | MP0001764_abnormal_homeostasis | 1.12276177 |
| 56 | MP0002277_abnormal_respiratory_mucosa | 1.11094006 |
| 57 | MP0001672_abnormal_embryogenesis/_devel | 1.09606224 |
| 58 | MP0005380_embryogenesis_phenotype | 1.09606224 |
| 59 | MP0001119_abnormal_female_reproductive | 1.08892291 |
| 60 | MP0002163_abnormal_gland_morphology | 1.06260202 |
| 61 | MP0006276_abnormal_autonomic_nervous | 1.05743834 |
| 62 | MP0003880_abnormal_central_pattern | 1.04922994 |
| 63 | MP0005636_abnormal_mineral_homeostasis | 1.04054388 |
| 64 | MP0002396_abnormal_hematopoietic_system | 1.03412327 |
| 65 | MP0000049_abnormal_middle_ear | 1.02442380 |
| 66 | MP0004133_heterotaxia | 1.01873429 |
| 67 | MP0003315_abnormal_perineum_morphology | 1.01336241 |
| 68 | MP0005408_hypopigmentation | 0.99486855 |
| 69 | MP0000678_abnormal_parathyroid_gland | 0.97092177 |
| 70 | MP0005220_abnormal_exocrine_pancreas | 0.96236735 |
| 71 | MP0008789_abnormal_olfactory_epithelium | 0.95514329 |
| 72 | MP0002102_abnormal_ear_morphology | 0.94093289 |
| 73 | MP0000858_altered_metastatic_potential | 0.92898917 |
| 74 | MP0003656_abnormal_erythrocyte_physiolo | 0.92896946 |
| 75 | MP0004808_abnormal_hematopoietic_stem | 0.92783486 |
| 76 | MP0004782_abnormal_surfactant_physiolog | 0.92494125 |
| 77 | MP0001968_abnormal_touch/_nociception | 0.92456680 |
| 78 | MP0003984_embryonic_growth_retardation | 0.92394648 |
| 79 | MP0001919_abnormal_reproductive_system | 0.92075551 |
| 80 | MP0002085_abnormal_embryonic_tissue | 0.90303703 |
| 81 | MP0001542_abnormal_bone_strength | 0.90184544 |
| 82 | MP0005058_abnormal_lysosome_morphology | 0.89477939 |
| 83 | MP0001835_abnormal_antigen_presentation | 0.87874599 |
| 84 | MP0002088_abnormal_embryonic_growth/wei | 0.87679697 |
| 85 | MP0002938_white_spotting | 0.87306580 |
| 86 | MP0002822_catalepsy | 0.85833896 |
| 87 | MP0006035_abnormal_mitochondrial_morpho | 0.84843689 |
| 88 | MP0008995_early_reproductive_senescence | 0.84673956 |
| 89 | MP0005395_other_phenotype | 0.84214978 |
| 90 | MP0002693_abnormal_pancreas_physiology | 0.83665900 |
| 91 | MP0009785_altered_susceptibility_to | 0.82656384 |
| 92 | MP0000689_abnormal_spleen_morphology | 0.81931502 |
| 93 | MP0002398_abnormal_bone_marrow | 0.81374915 |
| 94 | MP0002751_abnormal_autonomic_nervous | 0.80999551 |
| 95 | MP0008873_increased_physiological_sensi | 0.78927306 |
| 96 | MP0002722_abnormal_immune_system | 0.78291376 |
| 97 | MP0006292_abnormal_olfactory_placode | 0.77377067 |
| 98 | MP0001756_abnormal_urination | 0.75306390 |
| 99 | MP0002429_abnormal_blood_cell | 0.74722703 |
| 100 | MP0001944_abnormal_pancreas_morphology | 0.73942008 |
| 101 | MP0003763_abnormal_thymus_physiology | 0.73342163 |
| 102 | MP0009840_abnormal_foam_cell | 0.73056413 |
| 103 | MP0002405_respiratory_system_inflammati | 0.71909971 |
| 104 | MP0003699_abnormal_female_reproductive | 0.71802649 |
| 105 | MP0001873_stomach_inflammation | 0.70220284 |
| 106 | MP0001346_abnormal_lacrimal_gland | 0.69591138 |
| 107 | MP0005451_abnormal_body_composition | 0.68316534 |
| 108 | MP0000685_abnormal_immune_system | 0.68025365 |
| 109 | MP0005671_abnormal_response_to | 0.67942630 |
| 110 | MP0009643_abnormal_urine_homeostasis | 0.67766803 |
| 111 | MP0002084_abnormal_developmental_patter | 0.66907230 |
| 112 | MP0000703_abnormal_thymus_morphology | 0.66101102 |
| 113 | MP0010030_abnormal_orbit_morphology | 0.66081293 |
| 114 | MP0005384_cellular_phenotype | 0.66054971 |
| 115 | MP0005084_abnormal_gallbladder_morpholo | 0.64839529 |
| 116 | MP0000716_abnormal_immune_system | 0.63476947 |
| 117 | MP0009764_decreased_sensitivity_to | 0.62804701 |
| 118 | MP0008875_abnormal_xenobiotic_pharmacok | 0.61546698 |
| 119 | MP0005367_renal/urinary_system_phenotyp | 0.61201058 |
| 120 | MP0000516_abnormal_urinary_system | 0.61201058 |
| 121 | MP0001727_abnormal_embryo_implantation | 0.60961762 |
| 122 | MP0002234_abnormal_pharynx_morphology | 0.60798121 |
| 123 | MP0004264_abnormal_extraembryonic_tissu | 0.60681575 |
| 124 | MP0001293_anophthalmia | 0.60595485 |
| 125 | MP0000750_abnormal_muscle_regeneration | 0.60404471 |
| 126 | MP0002148_abnormal_hypersensitivity_rea | 0.60178716 |
| 127 | MP0009379_abnormal_foot_pigmentation | 0.60139933 |
| 128 | MP0002638_abnormal_pupillary_reflex | 0.59749194 |
| 129 | MP0001881_abnormal_mammary_gland | 0.59574200 |
| 130 | MP0005423_abnormal_somatic_nervous | 0.59485223 |
| 131 | MP0009765_abnormal_xenobiotic_induced | 0.58410542 |
| 132 | MP0003436_decreased_susceptibility_to | 0.58217032 |
| 133 | MP0001853_heart_inflammation | 0.58068611 |
| 134 | MP0001986_abnormal_taste_sensitivity | 0.57698964 |
| 135 | MP0005379_endocrine/exocrine_gland_phen | 0.56991204 |
| 136 | MP0005319_abnormal_enzyme/_coenzyme | 0.56927587 |
| 137 | MP0000343_altered_response_to | 0.55471196 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.40170582 |
| 2 | Chronic bronchitis (HP:0004469) | 4.83973774 |
| 3 | Abnormal respiratory motile cilium physiology (HP:0012261) | 4.05802313 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 3.97779256 |
| 5 | Rhinitis (HP:0012384) | 3.97672053 |
| 6 | Progressive macrocephaly (HP:0004481) | 3.93918188 |
| 7 | Increased intramyocellular lipid droplets (HP:0012240) | 3.91751560 |
| 8 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.89330142 |
| 9 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.89330142 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 3.86702584 |
| 11 | Absent/shortened dynein arms (HP:0200106) | 3.84032951 |
| 12 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.84032951 |
| 13 | Lipid accumulation in hepatocytes (HP:0006561) | 3.73109681 |
| 14 | Birth length less than 3rd percentile (HP:0003561) | 3.68999081 |
| 15 | Abnormal gallbladder physiology (HP:0012438) | 3.54279055 |
| 16 | Cholecystitis (HP:0001082) | 3.54279055 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.45744697 |
| 18 | Increased muscle lipid content (HP:0009058) | 3.42838810 |
| 19 | Abnormality of the anterior horn cell (HP:0006802) | 3.36253128 |
| 20 | Degeneration of anterior horn cells (HP:0002398) | 3.36253128 |
| 21 | Abnormal number of erythroid precursors (HP:0012131) | 3.32767339 |
| 22 | Oral leukoplakia (HP:0002745) | 3.29990488 |
| 23 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.29073108 |
| 24 | Lactic acidosis (HP:0003128) | 3.28052367 |
| 25 | Infertility (HP:0000789) | 3.16260403 |
| 26 | Microvesicular hepatic steatosis (HP:0001414) | 3.15051247 |
| 27 | Aplastic anemia (HP:0001915) | 3.13555658 |
| 28 | Rough bone trabeculation (HP:0100670) | 3.13288439 |
| 29 | Nasal polyposis (HP:0100582) | 3.11874362 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 3.11833725 |
| 31 | Carpal bone hypoplasia (HP:0001498) | 3.10612867 |
| 32 | Bronchitis (HP:0012387) | 3.09913685 |
| 33 | Cerebral edema (HP:0002181) | 3.03493700 |
| 34 | Abnormal ciliary motility (HP:0012262) | 3.02996382 |
| 35 | Breast hypoplasia (HP:0003187) | 2.98962036 |
| 36 | Bronchiectasis (HP:0002110) | 2.94769550 |
| 37 | Microretrognathia (HP:0000308) | 2.93920837 |
| 38 | Male infertility (HP:0003251) | 2.93909057 |
| 39 | Exercise intolerance (HP:0003546) | 2.93556098 |
| 40 | Pancreatic fibrosis (HP:0100732) | 2.90847265 |
| 41 | Impulsivity (HP:0100710) | 2.86697401 |
| 42 | Abnormal spermatogenesis (HP:0008669) | 2.82427638 |
| 43 | Patellar aplasia (HP:0006443) | 2.82304972 |
| 44 | Respiratory failure (HP:0002878) | 2.79050664 |
| 45 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.77158809 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.77158809 |
| 47 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.75792500 |
| 48 | Reticulocytopenia (HP:0001896) | 2.73998000 |
| 49 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.70684106 |
| 50 | Increased serum pyruvate (HP:0003542) | 2.70264981 |
| 51 | Secondary amenorrhea (HP:0000869) | 2.69497381 |
| 52 | Pancreatic cysts (HP:0001737) | 2.67643260 |
| 53 | Emotional lability (HP:0000712) | 2.64235789 |
| 54 | Cerebral hypomyelination (HP:0006808) | 2.63876247 |
| 55 | Respiratory difficulties (HP:0002880) | 2.63294843 |
| 56 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.62740482 |
| 57 | Progressive microcephaly (HP:0000253) | 2.60608962 |
| 58 | Abnormality of glycolysis (HP:0004366) | 2.59110746 |
| 59 | Abnormality of the nasal mucosa (HP:0000433) | 2.54689509 |
| 60 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.51107861 |
| 61 | Type I transferrin isoform profile (HP:0003642) | 2.49296908 |
| 62 | Exertional dyspnea (HP:0002875) | 2.48105915 |
| 63 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.48004907 |
| 64 | Multiple enchondromatosis (HP:0005701) | 2.42596012 |
| 65 | 11 pairs of ribs (HP:0000878) | 2.41340257 |
| 66 | Facial cleft (HP:0002006) | 2.34665940 |
| 67 | Poor head control (HP:0002421) | 2.33461351 |
| 68 | Testicular atrophy (HP:0000029) | 2.32549207 |
| 69 | Opisthotonus (HP:0002179) | 2.31537046 |
| 70 | Premature ovarian failure (HP:0008209) | 2.31370239 |
| 71 | Hypoplastic pelvis (HP:0008839) | 2.28017271 |
| 72 | True hermaphroditism (HP:0010459) | 2.27430438 |
| 73 | Optic disc pallor (HP:0000543) | 2.26952454 |
| 74 | Abnormal trabecular bone morphology (HP:0100671) | 2.26313519 |
| 75 | Acute necrotizing encephalopathy (HP:0006965) | 2.23013200 |
| 76 | Retinal dysplasia (HP:0007973) | 2.22859748 |
| 77 | Meckel diverticulum (HP:0002245) | 2.18686215 |
| 78 | Ragged-red muscle fibers (HP:0003200) | 2.17174889 |
| 79 | Cleft eyelid (HP:0000625) | 2.16452914 |
| 80 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.16396856 |
| 81 | Abnormality of the preputium (HP:0100587) | 2.16173375 |
| 82 | CNS demyelination (HP:0007305) | 2.16003436 |
| 83 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.15320506 |
| 84 | Hepatic necrosis (HP:0002605) | 2.14659924 |
| 85 | Increased IgM level (HP:0003496) | 2.14236791 |
| 86 | Bone marrow hypocellularity (HP:0005528) | 2.12185188 |
| 87 | Abnormal protein glycosylation (HP:0012346) | 2.10881761 |
| 88 | Abnormal glycosylation (HP:0012345) | 2.10881761 |
| 89 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.10881761 |
| 90 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.10881761 |
| 91 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.10553772 |
| 92 | Macrocytic anemia (HP:0001972) | 2.09735070 |
| 93 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.09432590 |
| 94 | Abnormality of the ileum (HP:0001549) | 2.07325742 |
| 95 | Trismus (HP:0000211) | 2.07135093 |
| 96 | Leukodystrophy (HP:0002415) | 2.06692484 |
| 97 | Gout (HP:0001997) | 2.02980522 |
| 98 | Hepatocellular necrosis (HP:0001404) | 2.01845758 |
| 99 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.01014520 |
| 100 | Absent epiphyses (HP:0010577) | 2.01014520 |
| 101 | Mitochondrial inheritance (HP:0001427) | 2.00687969 |
| 102 | Lethargy (HP:0001254) | 1.99855641 |
| 103 | Death in infancy (HP:0001522) | 1.99706886 |
| 104 | CNS hypomyelination (HP:0003429) | 1.97219276 |
| 105 | Cellular immunodeficiency (HP:0005374) | 1.96706536 |
| 106 | Premature graying of hair (HP:0002216) | 1.96422150 |
| 107 | Severe visual impairment (HP:0001141) | 1.95926694 |
| 108 | Recurrent bronchitis (HP:0002837) | 1.93873625 |
| 109 | Methylmalonic aciduria (HP:0012120) | 1.93060528 |
| 110 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.92611510 |
| 111 | Increased CSF lactate (HP:0002490) | 1.92540529 |
| 112 | Pallor (HP:0000980) | 1.90514021 |
| 113 | Abnormality of renal resorption (HP:0011038) | 1.90463631 |
| 114 | Delusions (HP:0000746) | 1.90320521 |
| 115 | Hypoplasia of the pons (HP:0012110) | 1.90290176 |
| 116 | Molar tooth sign on MRI (HP:0002419) | 1.90195297 |
| 117 | Abnormality of midbrain morphology (HP:0002418) | 1.90195297 |
| 118 | Increased serum lactate (HP:0002151) | 1.89948326 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.89260796 |
| 120 | Cholelithiasis (HP:0001081) | 1.89210418 |
| 121 | Sparse eyelashes (HP:0000653) | 1.88960764 |
| 122 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.88916435 |
| 123 | Hypokinesia (HP:0002375) | 1.88606736 |
| 124 | Pancytopenia (HP:0001876) | 1.86831985 |
| 125 | Sloping forehead (HP:0000340) | 1.86656169 |
| 126 | Acute encephalopathy (HP:0006846) | 1.86492393 |
| 127 | Nephronophthisis (HP:0000090) | 1.86268334 |
| 128 | Irregular epiphyses (HP:0010582) | 1.85346983 |
| 129 | Selective tooth agenesis (HP:0001592) | 1.84184820 |
| 130 | X-linked dominant inheritance (HP:0001423) | 1.84067421 |
| 131 | Hyperalaninemia (HP:0003348) | 1.84046931 |
| 132 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.84046931 |
| 133 | Abnormality of alanine metabolism (HP:0010916) | 1.84046931 |
| 134 | Reduced antithrombin III activity (HP:0001976) | 1.83942890 |
| 135 | Horseshoe kidney (HP:0000085) | 1.83449884 |
| 136 | Recurrent otitis media (HP:0000403) | 1.83197807 |
| 137 | Absent thumb (HP:0009777) | 1.83177713 |
| 138 | Thrombocytosis (HP:0001894) | 1.82771159 |
| 139 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.82732492 |
| 140 | Abnormality of the pons (HP:0007361) | 1.82552334 |
| 141 | Azoospermia (HP:0000027) | 1.80544350 |
| 142 | Poor suck (HP:0002033) | 1.79840127 |
| 143 | Personality changes (HP:0000751) | 1.79058654 |
| 144 | Postnatal microcephaly (HP:0005484) | 1.78105510 |
| 145 | Type 2 muscle fiber atrophy (HP:0003554) | 1.78000988 |
| 146 | Abnormality of chromosome stability (HP:0003220) | 1.77175296 |
| 147 | Myelodysplasia (HP:0002863) | 1.76709935 |
| 148 | Flat capital femoral epiphysis (HP:0003370) | 1.76429692 |
| 149 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.76105358 |
| 150 | Gliosis (HP:0002171) | 1.75091314 |
| 151 | Optic nerve coloboma (HP:0000588) | 1.74085207 |
| 152 | Neoplasm of the pancreas (HP:0002894) | 1.73769635 |
| 153 | Upper limb muscle weakness (HP:0003484) | 1.73383146 |
| 154 | Recurrent sinusitis (HP:0011108) | 1.73342185 |
| 155 | Progressive muscle weakness (HP:0003323) | 1.72147959 |
| 156 | Supernumerary spleens (HP:0009799) | 1.71515060 |
| 157 | Abnormality of the labia minora (HP:0012880) | 1.70618418 |
| 158 | Pulmonary fibrosis (HP:0002206) | 1.69783243 |
| 159 | Spastic paraparesis (HP:0002313) | 1.68212631 |
| 160 | Hypertensive crisis (HP:0100735) | 1.67382977 |
| 161 | Abnormal gallbladder morphology (HP:0012437) | 1.66287737 |
| 162 | Hypoplasia of the uterus (HP:0000013) | 1.66255439 |
| 163 | Type II lissencephaly (HP:0007260) | 1.65884387 |
| 164 | Entropion (HP:0000621) | 1.64948597 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.00370464 |
| 2 | BUB1 | 4.96674485 |
| 3 | WEE1 | 3.55280323 |
| 4 | TESK1 | 3.50393507 |
| 5 | STK16 | 3.17339768 |
| 6 | EIF2AK1 | 3.09260105 |
| 7 | PLK4 | 2.98071080 |
| 8 | PDK3 | 2.73050916 |
| 9 | PDK4 | 2.73050916 |
| 10 | NEK2 | 2.58448423 |
| 11 | BRSK2 | 2.47380920 |
| 12 | NME2 | 2.39061631 |
| 13 | EIF2AK3 | 2.11789862 |
| 14 | TESK2 | 2.07746410 |
| 15 | SRPK1 | 2.04595483 |
| 16 | MAP4K2 | 2.00655242 |
| 17 | DYRK3 | 1.98133717 |
| 18 | CDC7 | 1.94183516 |
| 19 | BRAF | 1.91075558 |
| 20 | VRK1 | 1.84453545 |
| 21 | PASK | 1.82181109 |
| 22 | TTK | 1.78842225 |
| 23 | BRSK1 | 1.75111433 |
| 24 | PLK1 | 1.69306394 |
| 25 | CCNB1 | 1.66540067 |
| 26 | PIM2 | 1.66325253 |
| 27 | TLK1 | 1.61599082 |
| 28 | PDK2 | 1.61446385 |
| 29 | ACVR1B | 1.60955399 |
| 30 | TRIM28 | 1.55599171 |
| 31 | RPS6KA4 | 1.55223546 |
| 32 | PRKD3 | 1.46472051 |
| 33 | CSNK1G3 | 1.40391399 |
| 34 | AURKB | 1.35944268 |
| 35 | AURKA | 1.30446339 |
| 36 | MAP2K7 | 1.29526046 |
| 37 | BCKDK | 1.28253489 |
| 38 | CHEK2 | 1.22237276 |
| 39 | STK38L | 1.10044449 |
| 40 | NEK1 | 1.09717644 |
| 41 | ERN1 | 1.09206684 |
| 42 | DAPK1 | 1.09008469 |
| 43 | CSNK1G2 | 1.08946244 |
| 44 | MAPKAPK3 | 1.08742130 |
| 45 | CDK19 | 1.08286052 |
| 46 | ARAF | 1.08195323 |
| 47 | MAP3K11 | 1.05438625 |
| 48 | TSSK6 | 1.04401100 |
| 49 | PLK3 | 1.03700280 |
| 50 | CSNK1A1L | 1.03203913 |
| 51 | CDK7 | 0.96952813 |
| 52 | EPHA2 | 0.96070794 |
| 53 | ATR | 0.95816551 |
| 54 | CSNK1G1 | 0.90368004 |
| 55 | MAPK15 | 0.90107252 |
| 56 | ZAK | 0.90099596 |
| 57 | NUAK1 | 0.89448698 |
| 58 | SIK3 | 0.83301622 |
| 59 | KDR | 0.81578323 |
| 60 | MAP3K8 | 0.79315330 |
| 61 | PIM1 | 0.76205829 |
| 62 | PAK4 | 0.76078490 |
| 63 | SCYL2 | 0.74536394 |
| 64 | CDK8 | 0.72932843 |
| 65 | PAK1 | 0.71987284 |
| 66 | MKNK2 | 0.71982128 |
| 67 | RAF1 | 0.71058429 |
| 68 | MAP3K12 | 0.69914539 |
| 69 | LIMK1 | 0.68304081 |
| 70 | ZAP70 | 0.67943600 |
| 71 | CSNK2A1 | 0.66210230 |
| 72 | AKT3 | 0.66040671 |
| 73 | IRAK3 | 0.65250786 |
| 74 | DYRK2 | 0.64421471 |
| 75 | CDK4 | 0.64140087 |
| 76 | EIF2AK2 | 0.63921131 |
| 77 | STK4 | 0.63476591 |
| 78 | NME1 | 0.61814913 |
| 79 | RPS6KB2 | 0.61709125 |
| 80 | DYRK1B | 0.61369184 |
| 81 | CHEK1 | 0.61204360 |
| 82 | MST4 | 0.58879184 |
| 83 | TAOK1 | 0.58385745 |
| 84 | STK10 | 0.58354009 |
| 85 | MKNK1 | 0.57666876 |
| 86 | ABL2 | 0.55802720 |
| 87 | BCR | 0.53926661 |
| 88 | EEF2K | 0.53535014 |
| 89 | STK3 | 0.53451847 |
| 90 | MAP3K10 | 0.53104078 |
| 91 | CDK14 | 0.52585579 |
| 92 | PRKCI | 0.52401057 |
| 93 | PINK1 | 0.52091947 |
| 94 | MAP3K3 | 0.51749941 |
| 95 | LMTK2 | 0.51316101 |
| 96 | PAK6 | 0.50960822 |
| 97 | SMG1 | 0.49880494 |
| 98 | LRRK2 | 0.48301926 |
| 99 | WNK3 | 0.46702539 |
| 100 | CDK11A | 0.46476180 |
| 101 | RPS6KA5 | 0.45516141 |
| 102 | CLK1 | 0.44557044 |
| 103 | PBK | 0.44294639 |
| 104 | CSNK2A2 | 0.44075393 |
| 105 | BLK | 0.43537957 |
| 106 | NEK9 | 0.43436511 |
| 107 | IKBKB | 0.43240011 |
| 108 | ATM | 0.36779136 |
| 109 | CDK18 | 0.36621707 |
| 110 | TAF1 | 0.36482370 |
| 111 | MAP3K5 | 0.36353302 |
| 112 | CDK2 | 0.36142402 |
| 113 | ILK | 0.36138438 |
| 114 | CDK15 | 0.35307889 |
| 115 | MAP4K1 | 0.34921172 |
| 116 | MAP2K2 | 0.34584292 |
| 117 | TYK2 | 0.34302172 |
| 118 | FLT3 | 0.34120316 |
| 119 | IRAK1 | 0.33145692 |
| 120 | TBK1 | 0.33011948 |
| 121 | AKT2 | 0.32498357 |
| 122 | MATK | 0.31513368 |
| 123 | TEC | 0.29823324 |
| 124 | TXK | 0.29587933 |
| 125 | DAPK3 | 0.29047052 |
| 126 | PIK3CG | 0.28361045 |
| 127 | IRAK2 | 0.27975769 |
| 128 | TAOK2 | 0.27205905 |
| 129 | NLK | 0.27035266 |
| 130 | LATS2 | 0.26652894 |
| 131 | BTK | 0.25447093 |
| 132 | IRAK4 | 0.25428710 |
| 133 | EPHB2 | 0.25243785 |
| 134 | GRK6 | 0.24389329 |
| 135 | MUSK | 0.22784441 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.23520932 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.05702663 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.71163911 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.27775705 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.19734161 |
| 6 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.95980743 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.95255503 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.74242545 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.60991033 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.59117994 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.56111212 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.52357443 |
| 13 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.47004482 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.43245772 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 2.22893999 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 2.21774038 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.94730012 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.85129085 |
| 19 | Purine metabolism_Homo sapiens_hsa00230 | 1.74462571 |
| 20 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.70073301 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.63174888 |
| 22 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.43172650 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.41425536 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.40821936 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.40612632 |
| 26 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.36762196 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.32319274 |
| 28 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.30812029 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.30560236 |
| 30 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.27397910 |
| 31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.26509048 |
| 32 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.26048386 |
| 33 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.22382592 |
| 34 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.20829844 |
| 35 | Parkinsons disease_Homo sapiens_hsa05012 | 1.16334261 |
| 36 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.14743314 |
| 37 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12506797 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.11086032 |
| 39 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.11015082 |
| 40 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.08308165 |
| 41 | Sulfur relay system_Homo sapiens_hsa04122 | 1.05657346 |
| 42 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.04451791 |
| 43 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.98675899 |
| 44 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.98520981 |
| 45 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.96415727 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.94903660 |
| 47 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.93032799 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.91328953 |
| 49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.89994791 |
| 50 | Legionellosis_Homo sapiens_hsa05134 | 0.87548896 |
| 51 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87183812 |
| 52 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.85531136 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.84204441 |
| 54 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.78895343 |
| 55 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.78575862 |
| 56 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.76117388 |
| 57 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74001272 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72442002 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.69799543 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67593621 |
| 61 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67185585 |
| 62 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.66903510 |
| 63 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.66254587 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.65480459 |
| 65 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.63077194 |
| 66 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.61683735 |
| 67 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.59532553 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59181419 |
| 69 | Galactose metabolism_Homo sapiens_hsa00052 | 0.59005651 |
| 70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.58303424 |
| 71 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57309850 |
| 72 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56211555 |
| 73 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.55614961 |
| 74 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.54663442 |
| 75 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.53663073 |
| 76 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.51983179 |
| 77 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.50903422 |
| 78 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48457261 |
| 79 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.48379657 |
| 80 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.45780766 |
| 81 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.44880515 |
| 82 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44811054 |
| 83 | Alzheimers disease_Homo sapiens_hsa05010 | 0.40016659 |
| 84 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.39565993 |
| 85 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.37429784 |
| 86 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.35966625 |
| 87 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35518612 |
| 88 | HTLV-I infection_Homo sapiens_hsa05166 | 0.30723626 |
| 89 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.28782970 |
| 90 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.28688481 |
| 91 | Apoptosis_Homo sapiens_hsa04210 | 0.28224819 |
| 92 | Alcoholism_Homo sapiens_hsa05034 | 0.28080952 |
| 93 | Phototransduction_Homo sapiens_hsa04744 | 0.27577626 |
| 94 | Thyroid cancer_Homo sapiens_hsa05216 | 0.27551114 |
| 95 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.27143576 |
| 96 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.26559520 |
| 97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.26487343 |
| 98 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.26405403 |
| 99 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.25683476 |
| 100 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.25016929 |
| 101 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.22325914 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.21973754 |
| 103 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.21598873 |
| 104 | Shigellosis_Homo sapiens_hsa05131 | 0.20890941 |
| 105 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.18800270 |
| 106 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.18701293 |
| 107 | Influenza A_Homo sapiens_hsa05164 | 0.18280914 |
| 108 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.16965839 |
| 109 | Measles_Homo sapiens_hsa05162 | 0.16931305 |
| 110 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.16885920 |
| 111 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.16565753 |
| 112 | Lysosome_Homo sapiens_hsa04142 | 0.16395230 |
| 113 | Peroxisome_Homo sapiens_hsa04146 | 0.14993498 |
| 114 | Salmonella infection_Homo sapiens_hsa05132 | 0.14923981 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.14447551 |
| 116 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.13965492 |
| 117 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.13539363 |
| 118 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.12929013 |
| 119 | Bladder cancer_Homo sapiens_hsa05219 | 0.12039106 |
| 120 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.11609884 |
| 121 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.11059490 |
| 122 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.11042285 |
| 123 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.10587381 |
| 124 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.10509795 |
| 125 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.08524136 |
| 126 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.08309532 |
| 127 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.06912011 |

