ELOVL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.65782829
2axon ensheathment in central nervous system (GO:0032291)7.65782829
3* fatty acid elongation (GO:0030497)5.46668838
4cholesterol biosynthetic process (GO:0006695)4.79328966
5surfactant homeostasis (GO:0043129)4.79181383
6axon ensheathment (GO:0008366)4.70673372
7ensheathment of neurons (GO:0007272)4.70673372
8amyloid precursor protein metabolic process (GO:0042982)4.60001271
9long-chain fatty acid biosynthetic process (GO:0042759)4.59406178
10myelination (GO:0042552)4.59127412
11COPI coating of Golgi vesicle (GO:0048205)4.56980478
12Golgi transport vesicle coating (GO:0048200)4.56980478
13adhesion of symbiont to host cell (GO:0044650)4.51385434
14virion attachment to host cell (GO:0019062)4.51385434
15amyloid precursor protein catabolic process (GO:0042987)4.33228956
16sterol biosynthetic process (GO:0016126)4.27120971
17myelin maintenance (GO:0043217)4.12011168
18neutrophil activation involved in immune response (GO:0002283)4.07641380
19barbed-end actin filament capping (GO:0051016)4.06496423
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94392607
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90228139
22adhesion of symbiont to host (GO:0044406)3.83939927
23desmosome organization (GO:0002934)3.74067356
24protein maturation by protein folding (GO:0022417)3.70587244
25skin morphogenesis (GO:0043589)3.60440608
26isoprenoid biosynthetic process (GO:0008299)3.56850038
27membrane raft organization (GO:0031579)3.56452802
28sphingosine metabolic process (GO:0006670)3.53914134
29response to lipoprotein particle (GO:0055094)3.52277485
30hemidesmosome assembly (GO:0031581)3.50960619
31antigen processing and presentation of endogenous antigen (GO:0019883)3.46344809
32chemical homeostasis within a tissue (GO:0048875)3.42675454
33pinocytosis (GO:0006907)3.41066294
34* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.36826440
35protein retention in ER lumen (GO:0006621)3.34564980
36macrophage activation involved in immune response (GO:0002281)3.33964131
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29836837
38* long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.29422173
39creatine metabolic process (GO:0006600)3.29198214
40sphingoid metabolic process (GO:0046519)3.24422828
41leukocyte migration involved in inflammatory response (GO:0002523)3.23126955
42diol metabolic process (GO:0034311)3.20133261
43positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.17565847
44signal peptide processing (GO:0006465)3.15874082
45GPI anchor biosynthetic process (GO:0006506)3.07510828
46glycosylceramide metabolic process (GO:0006677)3.06889704
47negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05097446
48autophagic vacuole fusion (GO:0000046)2.99503181
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98496199
50* fatty-acyl-CoA metabolic process (GO:0035337)2.97316829
51regulation of metalloenzyme activity (GO:0048552)2.93808893
52response to methylmercury (GO:0051597)2.91667636
53macrophage chemotaxis (GO:0048246)2.90104248
54* fatty-acyl-CoA biosynthetic process (GO:0046949)2.87834004
55hypotonic response (GO:0006971)2.86864274
56oligodendrocyte differentiation (GO:0048709)2.82813330
57positive regulation of pseudopodium assembly (GO:0031274)2.80077953
58membrane tubulation (GO:0097320)2.79829221
59cell adhesion mediated by integrin (GO:0033627)2.79344872
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77953388
61regulation of collateral sprouting (GO:0048670)2.77190225
62phagocytosis, engulfment (GO:0006911)2.75449983
63low-density lipoprotein particle clearance (GO:0034383)2.74781720
64regulation of water loss via skin (GO:0033561)2.73221774
65positive regulation of interleukin-17 production (GO:0032740)2.70151580
66GPI anchor metabolic process (GO:0006505)2.69213335
67positive regulation of actin filament depolymerization (GO:0030836)2.68495974
68positive regulation of Cdc42 GTPase activity (GO:0043089)2.67285624
69regulation of lipoprotein metabolic process (GO:0050746)2.65525342
70regulation of macrophage chemotaxis (GO:0010758)2.65429857
71negative regulation of chemokine production (GO:0032682)2.64388174
72membrane protein ectodomain proteolysis (GO:0006509)2.63168517
73pentose-phosphate shunt (GO:0006098)2.61266666
74nucleotide transmembrane transport (GO:1901679)2.60983601
75response to peptidoglycan (GO:0032494)2.57181787
76heme transport (GO:0015886)2.56822544
77NIK/NF-kappaB signaling (GO:0038061)2.56722106
78positive regulation of cellular amine metabolic process (GO:0033240)2.55802024
79regulation of mononuclear cell migration (GO:0071675)2.52266838
80respiratory burst (GO:0045730)2.52061620
81regulation of T cell migration (GO:2000404)2.51189462
82leukocyte aggregation (GO:0070486)2.49771970
83negative regulation of erythrocyte differentiation (GO:0045647)2.49136286
84chaperone mediated protein folding requiring cofactor (GO:0051085)2.48865539
85positive regulation of oligodendrocyte differentiation (GO:0048714)2.47742283
86* very long-chain fatty acid metabolic process (GO:0000038)2.47666703
87negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47010165
88hyaluronan catabolic process (GO:0030214)2.46996134
89endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46695503
90regulation of pseudopodium assembly (GO:0031272)2.46581643
91preassembly of GPI anchor in ER membrane (GO:0016254)2.46253098
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45428538
93negative regulation of protein localization to cell surface (GO:2000009)2.45257291
94cell-substrate junction assembly (GO:0007044)2.44719980
95negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.44198080
96negative regulation of acute inflammatory response (GO:0002674)2.42728991
97cellular copper ion homeostasis (GO:0006878)2.42617789
98establishment of skin barrier (GO:0061436)2.41914213
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41873854
100glutathione biosynthetic process (GO:0006750)2.41794015
101mesodermal cell differentiation (GO:0048333)2.41636296
102fibril organization (GO:0097435)2.41265728
103basement membrane organization (GO:0071711)2.40789203
104negative regulation of protein localization to plasma membrane (GO:1903077)2.40655329
105import into cell (GO:0098657)2.40525793
106regulation of interleukin-13 production (GO:0032656)2.40467497
107negative regulation of response to reactive oxygen species (GO:1901032)2.40051641
108mitotic nuclear envelope reassembly (GO:0007084)2.38944216
109nuclear envelope reassembly (GO:0031468)2.38944216
110cholesterol metabolic process (GO:0008203)2.37327223
111detection of bacterium (GO:0016045)2.36896309
112response to progesterone (GO:0032570)2.36657381
113neutrophil activation (GO:0042119)2.35733838
114membrane protein proteolysis (GO:0033619)2.35302502
115mannose metabolic process (GO:0006013)2.35230939
116detection of other organism (GO:0098543)2.34980153
117regulation of early endosome to late endosome transport (GO:2000641)2.34738699
118positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34538277
119negative regulation of stress fiber assembly (GO:0051497)2.34345092
120regulation of extracellular matrix disassembly (GO:0010715)2.33903547
121muscle cell migration (GO:0014812)2.33537134
122proline biosynthetic process (GO:0006561)2.33332350
123response to redox state (GO:0051775)2.31046358
124nonribosomal peptide biosynthetic process (GO:0019184)2.30807254
125phosphatidylserine acyl-chain remodeling (GO:0036150)2.30094650
126protein localization to endosome (GO:0036010)2.29437286
127glycosphingolipid catabolic process (GO:0046479)2.29432113
128regulation of superoxide anion generation (GO:0032928)2.29051456
129negative regulation of neurotransmitter secretion (GO:0046929)2.28910748
130eye photoreceptor cell differentiation (GO:0001754)2.28726794
131photoreceptor cell differentiation (GO:0046530)2.28726794
132GDP-mannose metabolic process (GO:0019673)2.28384327
133apoptotic cell clearance (GO:0043277)2.28051395
134substantia nigra development (GO:0021762)2.26863362
135stress fiber assembly (GO:0043149)2.26854953
136glutathione derivative metabolic process (GO:1901685)2.26816953
137glutathione derivative biosynthetic process (GO:1901687)2.26816953
138interleukin-6-mediated signaling pathway (GO:0070102)2.26703548
139positive regulation of receptor recycling (GO:0001921)2.26694871
140response to lead ion (GO:0010288)2.26480347
141T-helper 1 type immune response (GO:0042088)2.25665059
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25249176
143membrane invagination (GO:0010324)2.24894251
144alcohol biosynthetic process (GO:0046165)2.24791213
145* acyl-CoA biosynthetic process (GO:0071616)2.24124142
146* thioester biosynthetic process (GO:0035384)2.24124142
147response to thyroid hormone (GO:0097066)2.24109410
148tissue regeneration (GO:0042246)2.23940164
149glucose catabolic process (GO:0006007)2.23843487
150myeloid cell activation involved in immune response (GO:0002275)2.23719479
151negative regulation of nitric oxide biosynthetic process (GO:0045019)2.23511027
152astrocyte development (GO:0014002)2.22892650
153histone H4-K12 acetylation (GO:0043983)2.22832335
154embryonic process involved in female pregnancy (GO:0060136)2.21681177
155mitochondrial calcium ion transport (GO:0006851)2.21176767
156NADPH regeneration (GO:0006740)2.20617951
157cyclooxygenase pathway (GO:0019371)2.20103758
158positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.19863089
159positive regulation of monocyte chemotaxis (GO:0090026)2.19548726
160membrane protein intracellular domain proteolysis (GO:0031293)2.19288306
161negative regulation of interleukin-12 production (GO:0032695)2.18896335
162myeloid cell homeostasis (GO:0002262)2.18718564
163regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18644905
164cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.18499633
165positive regulation of lamellipodium assembly (GO:0010592)2.18445446
166positive regulation of protein dephosphorylation (GO:0035307)2.17290080
167magnesium ion transport (GO:0015693)2.17189982
168regulation of lymphocyte migration (GO:2000401)2.16893341
169regulation of necrotic cell death (GO:0010939)2.16873461
170mannosylation (GO:0097502)2.16601776
171protein palmitoylation (GO:0018345)2.16407052
172keratinization (GO:0031424)2.16389662
173granulocyte activation (GO:0036230)2.16292703
174C-terminal protein lipidation (GO:0006501)2.16120632
175glycolipid catabolic process (GO:0019377)2.15973166
176aldehyde catabolic process (GO:0046185)2.15760585
177lipoxygenase pathway (GO:0019372)2.15667197
178cellular defense response (GO:0006968)2.14830707
179positive regulation of extracellular matrix organization (GO:1903055)2.14372621
180organelle membrane fusion (GO:0090174)2.10923668
181regulation of cholesterol storage (GO:0010885)2.09621291
182defense response to Gram-negative bacterium (GO:0050829)2.08361909
183regulation of defense response to virus by virus (GO:0050690)2.08099933
184response to laminar fluid shear stress (GO:0034616)2.08005928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.91309749
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.79001353
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.73128701
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.64981607
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.63821292
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.01560733
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82644249
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68567582
9* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46052301
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.38991573
11* LXR_22292898_ChIP-Seq_THP-1_Human2.27372367
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25385894
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19794919
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.17407597
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16674559
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12800324
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07708529
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07622780
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06055862
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05416223
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03728765
22P63_26484246_Chip-Seq_KERATINOCYTES_Human2.02780742
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01169801
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00231282
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90327229
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87504092
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87012190
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.86430212
29* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84211255
30SCL_19346495_ChIP-Seq_HPC-7_Human1.79398751
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74681027
32* SOX2_20726797_ChIP-Seq_SW620_Human1.74114626
33ZNF263_19887448_ChIP-Seq_K562_Human1.72290440
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71453030
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61356057
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59161205
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56231784
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55954627
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55010115
40* VDR_24763502_ChIP-Seq_THP-1_Human1.54606974
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53140396
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52824775
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51936623
44* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50861130
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50370973
46ATF3_27146783_Chip-Seq_COLON_Human1.49723561
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48842998
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48423391
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46595139
50CLOCK_20551151_ChIP-Seq_293T_Human1.44832076
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44812474
52* SPI1_23547873_ChIP-Seq_NB4_Human1.44665931
53MYC_22102868_ChIP-Seq_BL_Human1.44591183
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44388589
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42636289
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41849734
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41231635
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40587258
59TCF7_22412390_ChIP-Seq_EML_Mouse1.37758494
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36494749
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35272115
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.34165984
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30075147
64GATA1_22025678_ChIP-Seq_K562_Human1.29820635
65GATA1_19941826_ChIP-Seq_K562_Human1.29337697
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29022104
67GATA4_25053715_ChIP-Seq_YYC3_Human1.28849953
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27388067
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26117038
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25787237
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25580410
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.25526119
73BCL6_27268052_Chip-Seq_Bcells_Human1.22370906
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.21289078
75* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21245358
76* KDM2B_26808549_Chip-Seq_DND41_Human1.21018833
77RUNX_20019798_ChIP-Seq_JUKART_Human1.19658870
78* UTX_26944678_Chip-Seq_JUKART_Human1.19180634
79* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18131010
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17925275
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17511760
82* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16791229
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16306194
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.15771931
85BCOR_27268052_Chip-Seq_Bcells_Human1.15413249
86* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15004486
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14514600
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14263100
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13897472
90* RUNX1_22412390_ChIP-Seq_EML_Mouse1.12921584
91P68_20966046_ChIP-Seq_HELA_Human1.12644928
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12474598
93VDR_21846776_ChIP-Seq_THP-1_Human1.12240908
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11683916
95EGR1_19032775_ChIP-ChIP_M12_Human1.11601959
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.10912266
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09625898
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09550722
99MAF_26560356_Chip-Seq_TH2_Human1.09047833
100* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08902131
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08720342
102STAT1_20625510_ChIP-Seq_HELA_Human1.08691226
103MYB_26560356_Chip-Seq_TH2_Human1.08079492
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07543088
105* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07237668
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06964353
107NCOR1_26117541_ChIP-Seq_K562_Human1.06653497
108* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05135914
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04958043
110NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04958043
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04475500
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03487115
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03441892
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02908655
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02738888
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.02290902
117SMC4_20622854_ChIP-Seq_HELA_Human1.02003251
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01951319
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01321121
120LXR_22158963_ChIP-Seq_LIVER_Mouse1.01271214
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01071513
122JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00782002
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99783289
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99650984
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99650984
126* MAF_26560356_Chip-Seq_TH1_Human0.98807095
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98119559
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96992515
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96159452
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94696478
131FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94650133
132FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94156902
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93884816
134RACK7_27058665_Chip-Seq_MCF-7_Human0.93014574
135GABP_17652178_ChIP-ChIP_JURKAT_Human0.93012546
136* SPI1_23127762_ChIP-Seq_K562_Human0.91703274
137CTCF_20526341_ChIP-Seq_ESCs_Human0.91579267
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91490369
139LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90238634
140* GATA2_19941826_ChIP-Seq_K562_Human0.89748200
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89655166
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89564238
143GATA3_26560356_Chip-Seq_TH2_Human0.89390401
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88717172
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87883441
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86993904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.86596105
2MP0004782_abnormal_surfactant_physiolog3.43634327
3MP0003950_abnormal_plasma_membrane3.41510679
4MP0003724_increased_susceptibility_to2.97478941
5MP0003705_abnormal_hypodermis_morpholog2.86816042
6MP0005058_abnormal_lysosome_morphology2.82315452
7MP0001958_emphysema2.55400547
8MP0010234_abnormal_vibrissa_follicle2.54618715
9MP0008438_abnormal_cutaneous_collagen2.48512052
10MP0003806_abnormal_nucleotide_metabolis2.35120791
11MP0002796_impaired_skin_barrier2.30537349
12MP0002877_abnormal_melanocyte_morpholog2.23993067
13MP0003191_abnormal_cellular_cholesterol2.21826965
14MP0005451_abnormal_body_composition2.20986685
15MP0006082_CNS_inflammation2.16731815
16MP0004381_abnormal_hair_follicle2.07514026
17MP0002148_abnormal_hypersensitivity_rea2.06666316
18MP0009785_altered_susceptibility_to2.01419451
19MP0009840_abnormal_foam_cell2.01180266
20MP0003300_gastrointestinal_ulcer2.00807430
21MP0000383_abnormal_hair_follicle1.96943306
22MP0005275_abnormal_skin_tensile1.96836829
23MP0010678_abnormal_skin_adnexa1.95544050
24MP0003436_decreased_susceptibility_to1.93617794
25MP0005083_abnormal_biliary_tract1.92540736
26MP0003690_abnormal_glial_cell1.90240434
27MP0001835_abnormal_antigen_presentation1.88180061
28MP0005025_abnormal_response_to1.86077288
29MP0004147_increased_porphyrin_level1.83549861
30MP0003656_abnormal_erythrocyte_physiolo1.81915863
31MP0002419_abnormal_innate_immunity1.80891034
32MP0000858_altered_metastatic_potential1.80269311
33MP0000465_gastrointestinal_hemorrhage1.78107497
34MP0001851_eye_inflammation1.73439335
35MP0005000_abnormal_immune_tolerance1.69197499
36MP0004947_skin_inflammation1.67602698
37MP0008004_abnormal_stomach_pH1.64544266
38MP0002295_abnormal_pulmonary_circulatio1.62705689
39MP0005501_abnormal_skin_physiology1.61053468
40MP0005387_immune_system_phenotype1.60916981
41MP0001790_abnormal_immune_system1.60916981
42MP0000685_abnormal_immune_system1.57057548
43MP0003279_aneurysm1.51198379
44MP0003186_abnormal_redox_activity1.50589399
45MP0006054_spinal_hemorrhage1.48756250
46MP0003453_abnormal_keratinocyte_physiol1.48498049
47MP0001533_abnormal_skeleton_physiology1.45175732
48MP0005257_abnormal_intraocular_pressure1.37806150
49MP0002933_joint_inflammation1.37346080
50MP0001849_ear_inflammation1.37138346
51MP0005408_hypopigmentation1.36675876
52MP0005464_abnormal_platelet_physiology1.36132716
53MP0002723_abnormal_immune_serum1.35237590
54MP0005166_decreased_susceptibility_to1.34849894
55MP0005671_abnormal_response_to1.32346781
56MP0003091_abnormal_cell_migration1.31250096
57MP0002452_abnormal_antigen_presenting1.27105438
58MP0003136_yellow_coat_color1.25535099
59MP0008260_abnormal_autophagy1.25447538
60MP0002405_respiratory_system_inflammati1.22123156
61MP0003329_amyloid_beta_deposits1.22105971
62MP0002133_abnormal_respiratory_system1.21204686
63MP0005388_respiratory_system_phenotype1.21204686
64MP0000604_amyloidosis1.20630190
65MP0002098_abnormal_vibrissa_morphology1.20060577
66MP0009333_abnormal_splenocyte_physiolog1.18074174
67MP0002060_abnormal_skin_morphology1.17313969
68MP0001853_heart_inflammation1.17158692
69MP0002132_abnormal_respiratory_system1.16929275
70MP0002420_abnormal_adaptive_immunity1.16744646
71MP0000343_altered_response_to1.16540305
72MP0001819_abnormal_immune_cell1.15757886
73MP0001216_abnormal_epidermal_layer1.14746597
74MP0005165_increased_susceptibility_to1.12757086
75MP0001243_abnormal_dermal_layer1.11910947
76MP0000647_abnormal_sebaceous_gland1.10908351
77MP0003763_abnormal_thymus_physiology1.08856408
78MP0003075_altered_response_to1.07901424
79MP0001800_abnormal_humoral_immune1.06991619
80MP0005164_abnormal_response_to1.06395670
81MP0010771_integument_phenotype1.06352131
82MP0003303_peritoneal_inflammation1.05899123
83MP0003634_abnormal_glial_cell1.04944540
84MP0003172_abnormal_lysosome_physiology1.04502061
85MP0004883_abnormal_blood_vessel1.03970211
86MP0004858_abnormal_nervous_system1.03963393
87MP0010155_abnormal_intestine_physiology1.03926907
88MP0001915_intracranial_hemorrhage1.02842179
89MP0000750_abnormal_muscle_regeneration1.02821716
90MP0004272_abnormal_basement_membrane1.00742722
91MP0001542_abnormal_bone_strength0.99856622
92MP0008469_abnormal_protein_level0.99732510
93MP0005023_abnormal_wound_healing0.98300344
94MP0001845_abnormal_inflammatory_respons0.97863621
95MP0000377_abnormal_hair_follicle0.96473628
96MP0005623_abnormal_meninges_morphology0.95604249
97MP0000566_synostosis0.94382749
98MP0005409_darkened_coat_color0.93966423
99MP0005666_abnormal_adipose_tissue0.92501100
100MP0000579_abnormal_nail_morphology0.92333299
101MP0010352_gastrointestinal_tract_polyps0.91455559
102MP0005075_abnormal_melanosome_morpholog0.90946421
103MP0003828_pulmonary_edema0.89063614
104MP0004185_abnormal_adipocyte_glucose0.88894994
105MP0003045_fibrosis0.86994841
106MP0005390_skeleton_phenotype0.86716798
107MP0003448_altered_tumor_morphology0.86377910
108MP0003195_calcinosis0.85996276
109MP0003183_abnormal_peptide_metabolism0.85767222
110MP0004742_abnormal_vestibular_system0.84400677
111MP0000249_abnormal_blood_vessel0.83412123
112MP0003566_abnormal_cell_adhesion0.82910756
113MP0009764_decreased_sensitivity_to0.82112206
114MP0003795_abnormal_bone_structure0.81659628
115MP0005375_adipose_tissue_phenotype0.81370351
116MP0010368_abnormal_lymphatic_system0.80165938
117MP0000467_abnormal_esophagus_morphology0.79995433
118MP0000462_abnormal_digestive_system0.79918508
119MP0000003_abnormal_adipose_tissue0.79908259
120MP0003011_delayed_dark_adaptation0.79600761
121MP0000716_abnormal_immune_system0.79397242
122MP0004510_myositis0.78798442
123MP0001177_atelectasis0.77638463
124MP0005360_urolithiasis0.76415790
125MP0002896_abnormal_bone_mineralization0.76349951
126MP0005171_absent_coat_pigmentation0.75659094
127MP0009931_abnormal_skin_appearance0.75461101
128MP0001346_abnormal_lacrimal_gland0.74808997
129MP0002998_abnormal_bone_remodeling0.74736401
130MP0002118_abnormal_lipid_homeostasis0.72119857
131MP0009643_abnormal_urine_homeostasis0.71854990
132MP0003632_abnormal_nervous_system0.70073029

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.37496774
2Interstitial pulmonary disease (HP:0006530)4.95088451
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.85256689
4Neurofibrillary tangles (HP:0002185)4.54437388
5Congenital ichthyosiform erythroderma (HP:0007431)4.45961294
6Vertebral compression fractures (HP:0002953)3.89945947
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.57828359
8Axonal loss (HP:0003447)3.45849693
9Hepatosplenomegaly (HP:0001433)3.43208176
10Abnormality of macrophages (HP:0004311)3.38536226
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.16932031
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.16932031
13Protrusio acetabuli (HP:0003179)3.16448573
14Segmental peripheral demyelination/remyelination (HP:0003481)3.16324535
15Achilles tendon contracture (HP:0001771)3.11891578
16Vacuolated lymphocytes (HP:0001922)3.08061277
17Loss of speech (HP:0002371)3.02348860
18Chronic otitis media (HP:0000389)3.02146479
19Recurrent abscess formation (HP:0002722)2.97892818
20Eczematoid dermatitis (HP:0000976)2.93697270
21Peripheral hypomyelination (HP:0007182)2.92437532
22Elevated erythrocyte sedimentation rate (HP:0003565)2.91370184
23Sensory axonal neuropathy (HP:0003390)2.89722797
24Premature skin wrinkling (HP:0100678)2.89344871
25Stridor (HP:0010307)2.84946608
26Cerebral hypomyelination (HP:0006808)2.82364934
27Abnormality of the Achilles tendon (HP:0005109)2.82143483
28Recurrent bacterial skin infections (HP:0005406)2.82004927
29Cerebral inclusion bodies (HP:0100314)2.78449065
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.78074126
31Onion bulb formation (HP:0003383)2.65132314
32Erythroderma (HP:0001019)2.54275110
33Atrophic scars (HP:0001075)2.52415358
34Distal lower limb muscle weakness (HP:0009053)2.51111251
35Respiratory distress (HP:0002098)2.47843065
36Prolonged neonatal jaundice (HP:0006579)2.47240471
37Increased serum pyruvate (HP:0003542)2.46059718
38Abnormality of glycolysis (HP:0004366)2.46059718
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.45848202
40Osteolytic defects of the hand bones (HP:0009699)2.45848202
41Reduced subcutaneous adipose tissue (HP:0003758)2.45658382
42Increased cerebral lipofuscin (HP:0011813)2.45655550
43Abnormality of nail color (HP:0100643)2.42399648
44Recurrent skin infections (HP:0001581)2.36406847
45Fragile skin (HP:0001030)2.35975152
46Short nail (HP:0001799)2.31257153
47Cerebral hemorrhage (HP:0001342)2.29642857
48Purpura (HP:0000979)2.28039609
49Cervical subluxation (HP:0003308)2.27659654
50Increased connective tissue (HP:0009025)2.24059789
51Premature rupture of membranes (HP:0001788)2.23621613
52Stomatitis (HP:0010280)2.21915961
53Hypertriglyceridemia (HP:0002155)2.21274407
54Abnormality of the distal phalanges of the toes (HP:0010182)2.20393508
55Autoamputation (HP:0001218)2.18753302
56Renal salt wasting (HP:0000127)2.16701382
57Petechiae (HP:0000967)2.15737557
58Plantar hyperkeratosis (HP:0007556)2.12237453
59Renal Fanconi syndrome (HP:0001994)2.11304883
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11296869
61Abnormality of polysaccharide metabolism (HP:0011012)2.11296869
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11296869
63Distal lower limb amyotrophy (HP:0008944)2.11072899
64Spastic paraparesis (HP:0002313)2.09934718
65Urinary glycosaminoglycan excretion (HP:0003541)2.09229691
66Mucopolysacchariduria (HP:0008155)2.09229691
67Thick nail (HP:0001805)2.08806464
68Systemic lupus erythematosus (HP:0002725)2.06110434
69Patchy hypopigmentation of hair (HP:0011365)2.02744769
70Supranuclear gaze palsy (HP:0000605)2.01314269
71Abnormal umbilical cord blood vessels (HP:0011403)2.01301402
72Single umbilical artery (HP:0001195)2.01301402
73Abnormality of the fetal cardiovascular system (HP:0010948)2.01301402
74Palmoplantar hyperkeratosis (HP:0000972)2.01019556
75Alopecia of scalp (HP:0002293)2.00511743
76Ileus (HP:0002595)2.00487615
77Upper limb amyotrophy (HP:0009129)2.00402489
78Distal upper limb amyotrophy (HP:0007149)2.00402489
79Erythema (HP:0010783)2.00208387
80Ectropion (HP:0000656)1.99995894
81Nail dystrophy (HP:0008404)1.99130277
82Amyloidosis (HP:0011034)1.97365260
83Gangrene (HP:0100758)1.96631481
84Acanthosis nigricans (HP:0000956)1.95763165
85White forelock (HP:0002211)1.95162229
86Abnormality of the umbilical cord (HP:0010881)1.93633325
87Abnormal blistering of the skin (HP:0008066)1.92698844
88Xanthomatosis (HP:0000991)1.92085671
89Hypoplastic pelvis (HP:0008839)1.91305328
90Myocardial infarction (HP:0001658)1.91059260
91Dysostosis multiplex (HP:0000943)1.90285503
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90064144
93Glucose intolerance (HP:0000833)1.88930969
94Elbow flexion contracture (HP:0002987)1.88863608
95Peripheral demyelination (HP:0011096)1.88074652
96Slow saccadic eye movements (HP:0000514)1.87962536
97Abnormal auditory evoked potentials (HP:0006958)1.87938958
98Peritonitis (HP:0002586)1.87750629
99Trismus (HP:0000211)1.87740422
100Pustule (HP:0200039)1.86392334
101Nonimmune hydrops fetalis (HP:0001790)1.85658932
102Joint stiffness (HP:0001387)1.85597802
103Corneal erosion (HP:0200020)1.83114532
104Polygenic inheritance (HP:0010982)1.82788895
105Recurrent gram-negative bacterial infections (HP:0005420)1.82594165
106Hypokalemic alkalosis (HP:0001949)1.82494836
107Wormian bones (HP:0002645)1.81434242
108Hypergammaglobulinemia (HP:0010702)1.80803804
109Increased serum ferritin (HP:0003281)1.80619711
110Right ventricular cardiomyopathy (HP:0011663)1.79824692
111Progressive neurologic deterioration (HP:0002344)1.79443412
112Rough bone trabeculation (HP:0100670)1.79222726
113Partial duplication of thumb phalanx (HP:0009944)1.78411738
114Paralysis (HP:0003470)1.78182140
115Abnormality of the lumbar spine (HP:0100712)1.77602134
116Hypertensive crisis (HP:0100735)1.77269549
117Bone pain (HP:0002653)1.76771076
118Hypomagnesemia (HP:0002917)1.76758763
119Dilatation of the ascending aorta (HP:0005111)1.76699157
120Increased IgE level (HP:0003212)1.76614138
121Spinal rigidity (HP:0003306)1.76476344
122Cholecystitis (HP:0001082)1.76024143
123Abnormal gallbladder physiology (HP:0012438)1.76024143
124Abnormality of liposaccharide metabolism (HP:0010968)1.75248963
125Abnormality of glycosphingolipid metabolism (HP:0004343)1.75248963
126Abnormality of glycolipid metabolism (HP:0010969)1.75248963
127Palmar hyperkeratosis (HP:0010765)1.74226042
128Thin bony cortex (HP:0002753)1.74159076
129Leukodystrophy (HP:0002415)1.74111485
130Onycholysis (HP:0001806)1.73906421
131Generalized amyotrophy (HP:0003700)1.72489459
132Spinal cord lesions (HP:0100561)1.72135905
133Syringomyelia (HP:0003396)1.72135905
134Pili torti (HP:0003777)1.71945885
135Abnormal hair laboratory examination (HP:0003328)1.71318423
136Follicular hyperkeratosis (HP:0007502)1.70705860
137Increased variability in muscle fiber diameter (HP:0003557)1.70350657
138Natal tooth (HP:0000695)1.70018607
139Blue sclerae (HP:0000592)1.69068561
140Hyperparathyroidism (HP:0000843)1.68366286
141Centrally nucleated skeletal muscle fibers (HP:0003687)1.67426337
142J-shaped sella turcica (HP:0002680)1.67205843
143Pruritus (HP:0000989)1.66864980
144Spontaneous hematomas (HP:0007420)1.66724481
145Ulnar bowing (HP:0003031)1.66585616
146Tubulointerstitial fibrosis (HP:0005576)1.65810850
147Hemorrhage of the eye (HP:0011885)1.65687558
148Nuclear cataract (HP:0100018)1.65651632
149Cerebral aneurysm (HP:0004944)1.65605967
150Episodic fever (HP:0001954)1.65490543
151Abnormality of skeletal muscle fiber size (HP:0012084)1.64875050
152Ankle contracture (HP:0006466)1.64256919
153Cellulitis (HP:0100658)1.63966545
1543-Methylglutaconic aciduria (HP:0003535)1.63687611
155Cardiovascular calcification (HP:0011915)1.63389256
156Entropion (HP:0000621)1.62856978
157Urticaria (HP:0001025)1.62803074
158Stenosis of the external auditory canal (HP:0000402)1.61513408
159Seborrheic dermatitis (HP:0001051)1.57884843
160Anhidrosis (HP:0000970)1.56664247
161Barrel-shaped chest (HP:0001552)1.56432442
162Gingival bleeding (HP:0000225)1.55426054
163Chronic obstructive pulmonary disease (HP:0006510)1.55226483
164Obstructive lung disease (HP:0006536)1.55226483
165Abnormality of the 2nd finger (HP:0004100)1.54702931
166Fragile nails (HP:0001808)1.54525502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.83829710
2EPHB14.54847236
3TESK23.28192000
4MST43.07407273
5EPHA23.05156981
6PBK3.03965704
7OXSR13.03561131
8MAPKAPK52.48009038
9TRIB32.38454389
10LIMK12.21516848
11MET2.14275854
12BLK2.05520361
13WNK41.98422150
14RIPK11.95094697
15PTK21.94950676
16PIM21.88780265
17AKT31.88030110
18SCYL21.85158268
19SMG11.79690356
20NME21.75811963
21PKN11.70055504
22CDK191.63828891
23BCR1.59825560
24MAP4K11.59143705
25SIK11.55094729
26CLK11.54733803
27LRRK21.54632788
28TAOK21.52174875
29TRPM71.52157517
30FGFR21.46934386
31STK101.43664781
32TIE11.41074793
33BRAF1.39755152
34KDR1.39540814
35TAF11.38505785
36ZAP701.37402733
37ERN11.33344420
38TBK11.30079531
39LMTK21.29899912
40IRAK41.29600314
41MAPKAPK31.25803319
42TESK11.25068697
43MAP3K141.19640447
44TGFBR21.17351813
45KIT1.11275657
46BMPR1B1.08460287
47CSNK1G31.07860347
48MST1R1.06284771
49IKBKE1.05069827
50CSK1.04390053
51PRKD21.02672624
52ICK1.02022487
53CSNK1A1L0.99334705
54ROCK20.93812484
55MOS0.93608240
56PDGFRA0.93140272
57IKBKB0.92419103
58ILK0.89355890
59BTK0.88773330
60TYK20.88761558
61TEC0.87778442
62TNIK0.87156272
63DAPK10.86866140
64ITK0.86231850
65TTN0.86013826
66FGR0.85925948
67PRKCQ0.84988201
68MAP3K10.84245039
69RIPK40.82373492
70ABL20.80358498
71MAP2K20.80200500
72PTK60.76280764
73MAP3K30.74983460
74CSNK1G10.74859791
75MAP3K80.74337096
76PRPF4B0.71488045
77WNK10.71359918
78RPS6KA50.70617273
79NEK60.70223486
80LCK0.70186627
81PIK3CG0.69396081
82BCKDK0.68841105
83MAPK150.68403724
84CSF1R0.67649237
85JAK30.67534202
86PRKD10.67313933
87TXK0.67036126
88HIPK20.65828959
89MAP3K60.63397261
90MARK30.61817530
91PRKG20.61673992
92TAOK10.61043494
93KSR10.61022567
94DDR20.60389056
95EIF2AK30.60303758
96GSK3A0.59988291
97IRAK30.59473739
98MAP3K120.58836145
99MAP3K130.56789620
100PAK10.56454368
101PRKCI0.56426624
102LYN0.56323562
103MAP3K110.56275618
104MAPKAPK20.54446431
105STK40.54139394
106VRK20.53909387
107TAOK30.53881439
108EPHB20.53252958
109PDGFRB0.52966123
110JAK10.51960303
111NEK90.51790388
112ABL10.51462791
113TLK10.51445196
114PAK40.50874601
115BMX0.50684772
116EIF2AK10.49799545
117CDC42BPA0.49660852
118CAMK2B0.49380255
119STK160.49270075
120BUB10.47229075
121PAK20.46885689
122PDPK10.46563050
123PRKCD0.45937654
124STK240.45606219
125KSR20.45185473
126GRK10.44899442
127DAPK30.44672218
128FYN0.43671874
129GRK60.42915953
130PKN20.42828401
131SYK0.42598751
132CAMK2D0.41567892
133MAP2K30.41504013
134MYLK0.41366640
135CAMK2G0.40505527
136ARAF0.39853944
137MAPK110.39779423
138NLK0.39779263
139FGFR40.37997508
140CSNK1G20.37929405
141HCK0.37137907
142PDK20.36356152
143SIK30.36264050
144ERBB40.36048858
145MAP2K60.35882915
146NTRK10.34990491
147UHMK10.34952425
148MAP2K10.33543324
149MAP3K20.33137982

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.64009835
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.51207159
3* Fatty acid elongation_Homo sapiens_hsa000623.34574416
4Ether lipid metabolism_Homo sapiens_hsa005652.62428853
5Protein export_Homo sapiens_hsa030602.58866087
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52143056
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31069575
8Sphingolipid metabolism_Homo sapiens_hsa006002.26067795
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17226642
10Histidine metabolism_Homo sapiens_hsa003402.13868530
11Lysosome_Homo sapiens_hsa041421.93789076
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91490355
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88403859
14Bladder cancer_Homo sapiens_hsa052191.80206750
15Malaria_Homo sapiens_hsa051441.78776592
16Sulfur metabolism_Homo sapiens_hsa009201.77677731
17Glutathione metabolism_Homo sapiens_hsa004801.60458330
18Galactose metabolism_Homo sapiens_hsa000521.56958474
19Acute myeloid leukemia_Homo sapiens_hsa052211.46375829
20Fructose and mannose metabolism_Homo sapiens_hsa000511.45844254
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42694850
22Linoleic acid metabolism_Homo sapiens_hsa005911.41614259
23Arachidonic acid metabolism_Homo sapiens_hsa005901.35616344
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35064812
25Chronic myeloid leukemia_Homo sapiens_hsa052201.33600740
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33126823
27Ribosome_Homo sapiens_hsa030101.32317466
28Pancreatic cancer_Homo sapiens_hsa052121.31720767
29Phagosome_Homo sapiens_hsa041451.31589566
30Other glycan degradation_Homo sapiens_hsa005111.31193318
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29186951
32Proteasome_Homo sapiens_hsa030501.26474546
33Folate biosynthesis_Homo sapiens_hsa007901.25829801
34Staphylococcus aureus infection_Homo sapiens_hsa051501.24839023
35Rheumatoid arthritis_Homo sapiens_hsa053231.24659305
36Pertussis_Homo sapiens_hsa051331.24610992
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23035624
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22589849
39Thyroid cancer_Homo sapiens_hsa052161.21756370
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21528956
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21274617
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21086409
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20208599
44Viral myocarditis_Homo sapiens_hsa054161.19893979
45Prion diseases_Homo sapiens_hsa050201.19886428
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19853084
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17735711
48VEGF signaling pathway_Homo sapiens_hsa043701.16167305
49Non-small cell lung cancer_Homo sapiens_hsa052231.15916561
50Caffeine metabolism_Homo sapiens_hsa002321.15895456
51N-Glycan biosynthesis_Homo sapiens_hsa005101.12411156
52TNF signaling pathway_Homo sapiens_hsa046681.10428861
53Oxidative phosphorylation_Homo sapiens_hsa001901.09715203
54Leishmaniasis_Homo sapiens_hsa051401.05785558
55Influenza A_Homo sapiens_hsa051641.05744055
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.05472416
57Mineral absorption_Homo sapiens_hsa049781.03745686
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01136501
59Peroxisome_Homo sapiens_hsa041461.00304205
60Graft-versus-host disease_Homo sapiens_hsa053321.00230296
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.99060974
62Focal adhesion_Homo sapiens_hsa045100.95984467
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95530779
64Small cell lung cancer_Homo sapiens_hsa052220.95417094
65Hematopoietic cell lineage_Homo sapiens_hsa046400.95310925
66Salmonella infection_Homo sapiens_hsa051320.92184616
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.90480330
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.90232125
69Sulfur relay system_Homo sapiens_hsa041220.89836678
70Arginine and proline metabolism_Homo sapiens_hsa003300.88810635
71ECM-receptor interaction_Homo sapiens_hsa045120.88101154
72Vitamin digestion and absorption_Homo sapiens_hsa049770.87788186
73Allograft rejection_Homo sapiens_hsa053300.87669096
74Asthma_Homo sapiens_hsa053100.87463121
75Shigellosis_Homo sapiens_hsa051310.85372456
76Proteoglycans in cancer_Homo sapiens_hsa052050.84213987
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83153758
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82532483
79Chemical carcinogenesis_Homo sapiens_hsa052040.81829448
80Fatty acid metabolism_Homo sapiens_hsa012120.81827653
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.79158272
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78863440
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78284691
84Biosynthesis of amino acids_Homo sapiens_hsa012300.77450663
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.76105364
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75964371
87Hepatitis B_Homo sapiens_hsa051610.75957690
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74196362
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73710686
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71571255
91Vitamin B6 metabolism_Homo sapiens_hsa007500.70678521
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69995811
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69895375
94Autoimmune thyroid disease_Homo sapiens_hsa053200.69029155
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68215729
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.68011274
97Retinol metabolism_Homo sapiens_hsa008300.67645151
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66579395
99Primary immunodeficiency_Homo sapiens_hsa053400.65981995
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.63276004
101Endocytosis_Homo sapiens_hsa041440.62280774
102Endometrial cancer_Homo sapiens_hsa052130.62051703
103Phenylalanine metabolism_Homo sapiens_hsa003600.61949098
104Glioma_Homo sapiens_hsa052140.61854433
105Parkinsons disease_Homo sapiens_hsa050120.60914554
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.60274028
107Carbon metabolism_Homo sapiens_hsa012000.58852603
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58573182
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57770185
110ABC transporters_Homo sapiens_hsa020100.56621084
111Renin-angiotensin system_Homo sapiens_hsa046140.56478147
112Tight junction_Homo sapiens_hsa045300.54563539
113Butanoate metabolism_Homo sapiens_hsa006500.54556725
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54456238
115Notch signaling pathway_Homo sapiens_hsa043300.53477231
116Antigen processing and presentation_Homo sapiens_hsa046120.53369414
117Pentose phosphate pathway_Homo sapiens_hsa000300.52307978
118Tuberculosis_Homo sapiens_hsa051520.51924853
119Hepatitis C_Homo sapiens_hsa051600.51363576
120Legionellosis_Homo sapiens_hsa051340.51361828
121Viral carcinogenesis_Homo sapiens_hsa052030.51315459
122HTLV-I infection_Homo sapiens_hsa051660.50827691
123Vibrio cholerae infection_Homo sapiens_hsa051100.50663001
124PPAR signaling pathway_Homo sapiens_hsa033200.50502071
125Alzheimers disease_Homo sapiens_hsa050100.49878171
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49605360
127Herpes simplex infection_Homo sapiens_hsa051680.49275144
128Osteoclast differentiation_Homo sapiens_hsa043800.48671370
129Toxoplasmosis_Homo sapiens_hsa051450.48203907
130Metabolic pathways_Homo sapiens_hsa011000.46731258
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46539277
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46213767
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45206309
134B cell receptor signaling pathway_Homo sapiens_hsa046620.43540811
135Measles_Homo sapiens_hsa051620.42873685
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42857533
137Insulin signaling pathway_Homo sapiens_hsa049100.42410125
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.41662703
139Complement and coagulation cascades_Homo sapiens_hsa046100.41174647
140Apoptosis_Homo sapiens_hsa042100.40846081
141Platelet activation_Homo sapiens_hsa046110.39374445
142beta-Alanine metabolism_Homo sapiens_hsa004100.39002710
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37705230
144Fatty acid degradation_Homo sapiens_hsa000710.37647400
145Chemokine signaling pathway_Homo sapiens_hsa040620.36187809
146Amoebiasis_Homo sapiens_hsa051460.35731765
147Renal cell carcinoma_Homo sapiens_hsa052110.35055338

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