ELOVL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61245919
2L-phenylalanine catabolic process (GO:0006559)7.61245919
3L-phenylalanine metabolic process (GO:0006558)7.24035036
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24035036
5aromatic amino acid family catabolic process (GO:0009074)6.81517134
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.49994720
7tryptophan catabolic process (GO:0006569)6.11177694
8indole-containing compound catabolic process (GO:0042436)6.11177694
9indolalkylamine catabolic process (GO:0046218)6.11177694
10kynurenine metabolic process (GO:0070189)6.01191592
11bile acid biosynthetic process (GO:0006699)5.97007179
12glyoxylate metabolic process (GO:0046487)5.82418447
13tryptophan metabolic process (GO:0006568)5.75518301
14high-density lipoprotein particle remodeling (GO:0034375)5.69831207
15urea metabolic process (GO:0019627)5.67497745
16urea cycle (GO:0000050)5.67497745
17* alpha-linolenic acid metabolic process (GO:0036109)5.67003670
18negative regulation of fibrinolysis (GO:0051918)5.63484103
19regulation of fibrinolysis (GO:0051917)5.43047444
20peptidyl-glutamic acid carboxylation (GO:0017187)5.34456422
21protein carboxylation (GO:0018214)5.34456422
22cysteine metabolic process (GO:0006534)5.30173549
23sulfur amino acid catabolic process (GO:0000098)5.29834577
24regulation of protein activation cascade (GO:2000257)5.27710761
25complement activation, alternative pathway (GO:0006957)5.25142917
26C4-dicarboxylate transport (GO:0015740)5.24764980
27nitrogen cycle metabolic process (GO:0071941)5.20015684
28serine family amino acid catabolic process (GO:0009071)5.13897663
29bile acid metabolic process (GO:0008206)5.11197527
30reverse cholesterol transport (GO:0043691)5.10496448
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00646321
32regulation of cholesterol esterification (GO:0010872)4.94400409
33aromatic amino acid family metabolic process (GO:0009072)4.92031811
34macromolecular complex remodeling (GO:0034367)4.90844673
35plasma lipoprotein particle remodeling (GO:0034369)4.90844673
36protein-lipid complex remodeling (GO:0034368)4.90844673
37regulation of complement activation (GO:0030449)4.90426804
38regulation of triglyceride catabolic process (GO:0010896)4.86828864
39tyrosine metabolic process (GO:0006570)4.81644750
40homocysteine metabolic process (GO:0050667)4.74315630
41postsynaptic membrane organization (GO:0001941)4.74087092
42amino-acid betaine metabolic process (GO:0006577)4.70039379
43acylglycerol homeostasis (GO:0055090)4.67940242
44triglyceride homeostasis (GO:0070328)4.67940242
45negative regulation of sterol transport (GO:0032372)4.66091727
46negative regulation of cholesterol transport (GO:0032375)4.66091727
47phospholipid efflux (GO:0033700)4.65448840
48alpha-amino acid catabolic process (GO:1901606)4.64113845
49lysine catabolic process (GO:0006554)4.62321927
50lysine metabolic process (GO:0006553)4.62321927
51cellular ketone body metabolic process (GO:0046950)4.61202907
52plasma lipoprotein particle clearance (GO:0034381)4.42172851
53presynaptic membrane assembly (GO:0097105)4.41246694
54bile acid and bile salt transport (GO:0015721)4.39593880
55glycine metabolic process (GO:0006544)4.36325605
56cholesterol efflux (GO:0033344)4.33713695
57coenzyme catabolic process (GO:0009109)4.32498050
58indolalkylamine metabolic process (GO:0006586)4.31677586
59glutamate metabolic process (GO:0006536)4.28782704
60cellular amino acid catabolic process (GO:0009063)4.26663957
61imidazole-containing compound metabolic process (GO:0052803)4.24587503
62amine catabolic process (GO:0009310)4.21572504
63cellular biogenic amine catabolic process (GO:0042402)4.21572504
64dicarboxylic acid biosynthetic process (GO:0043650)4.14677098
65cellular glucuronidation (GO:0052695)4.14501324
66serine family amino acid metabolic process (GO:0009069)4.13582189
67benzene-containing compound metabolic process (GO:0042537)4.12568029
68ethanol oxidation (GO:0006069)4.12273958
69plasma lipoprotein particle assembly (GO:0034377)4.10340722
70low-density lipoprotein particle remodeling (GO:0034374)4.09801270
71cellular modified amino acid catabolic process (GO:0042219)4.08526892
72ketone body metabolic process (GO:1902224)3.98757193
73arginine metabolic process (GO:0006525)3.97075969
74serine family amino acid biosynthetic process (GO:0009070)3.96827607
75fibrinolysis (GO:0042730)3.95066645
76phospholipid homeostasis (GO:0055091)3.89814683
77drug catabolic process (GO:0042737)3.87964925
78artery smooth muscle contraction (GO:0014824)3.86738542
79positive regulation of lipid catabolic process (GO:0050996)3.86450274
80aldehyde catabolic process (GO:0046185)3.84733384
81very-low-density lipoprotein particle assembly (GO:0034379)3.81534517
82positive regulation of lipoprotein lipase activity (GO:0051006)3.80868974
83positive regulation of triglyceride lipase activity (GO:0061365)3.80868974
84blood coagulation, intrinsic pathway (GO:0007597)3.80345262
85negative regulation of lipase activity (GO:0060192)3.77394720
86cellular response to leptin stimulus (GO:0044320)3.76103683
87cholesterol homeostasis (GO:0042632)3.74869849
88plasma lipoprotein particle organization (GO:0071827)3.74769673
89carboxylic acid catabolic process (GO:0046395)3.74288697
90organic acid catabolic process (GO:0016054)3.74288697
91regulation of bile acid biosynthetic process (GO:0070857)3.73390850
92acetyl-CoA metabolic process (GO:0006084)3.72749518
93regulation of cholesterol homeostasis (GO:2000188)3.72321860
94complement activation, classical pathway (GO:0006958)3.70841253
95sterol homeostasis (GO:0055092)3.68545151
96cofactor catabolic process (GO:0051187)3.68257079
97short-chain fatty acid metabolic process (GO:0046459)3.66799697
98complement activation (GO:0006956)3.66650825
99protein activation cascade (GO:0072376)3.66028675
100protein-lipid complex assembly (GO:0065005)3.65205443
101uronic acid metabolic process (GO:0006063)3.65132362
102glucuronate metabolic process (GO:0019585)3.65132362
103presynaptic membrane organization (GO:0097090)3.64244319
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.63614975
105cytolysis (GO:0019835)3.59397219
106neurotransmitter-gated ion channel clustering (GO:0072578)3.53422269
107protein-lipid complex subunit organization (GO:0071825)3.50856998
108vascular smooth muscle contraction (GO:0014829)3.36374382
109amino acid import (GO:0043090)3.34741693
110regulation of cardiac muscle cell contraction (GO:0086004)3.31699039
111pyrimidine nucleobase catabolic process (GO:0006208)3.27485687
112tonic smooth muscle contraction (GO:0014820)3.27115744
113intestinal cholesterol absorption (GO:0030299)3.23239200
114negative regulation of astrocyte differentiation (GO:0048712)3.22997899
115positive regulation of male gonad development (GO:2000020)3.08012085
116L-amino acid import (GO:0043092)3.00446753
117cellular sodium ion homeostasis (GO:0006883)2.99850428
118cellular response to cholesterol (GO:0071397)2.97939985
119response to leptin (GO:0044321)2.96476462
120regulation of plasminogen activation (GO:0010755)2.95507667
121glutamine family amino acid biosynthetic process (GO:0009084)2.95358781
122negative regulation of sodium ion transport (GO:0010766)2.95314173
123embryonic retina morphogenesis in camera-type eye (GO:0060059)2.93264550
124neurotransmitter uptake (GO:0001504)2.88565857
125nonmotile primary cilium assembly (GO:0035058)2.87789259
126proline metabolic process (GO:0006560)2.85873996
127L-serine metabolic process (GO:0006563)2.84296409
128auditory behavior (GO:0031223)2.80145474
129regulation of apoptotic cell clearance (GO:2000425)2.77202085
130oxidative demethylation (GO:0070989)2.76857751
131neuron cell-cell adhesion (GO:0007158)2.75941361
132cellular response to sterol (GO:0036315)2.71806293
133regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69484358
134regulation of cholesterol biosynthetic process (GO:0045540)2.69193362
135gamma-aminobutyric acid transport (GO:0015812)2.68274034
136sodium-independent organic anion transport (GO:0043252)2.63424512
137mechanosensory behavior (GO:0007638)2.58919786
138carnitine metabolic process (GO:0009437)2.58836370
139regulation of cilium movement (GO:0003352)2.54219265
140response to methylmercury (GO:0051597)2.53540812
141nucleobase catabolic process (GO:0046113)2.50844828
142axon ensheathment in central nervous system (GO:0032291)2.49672042
143central nervous system myelination (GO:0022010)2.49672042
144regulation of respiratory system process (GO:0044065)2.46878400
145oligodendrocyte differentiation (GO:0048709)2.46728454
146negative regulation of protein localization to cell surface (GO:2000009)2.46437190
147epoxygenase P450 pathway (GO:0019373)2.45493637
148negative regulation of protein activation cascade (GO:2000258)2.41666666
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41272795
150regulation of actin filament-based movement (GO:1903115)2.37365287
151protein localization to synapse (GO:0035418)2.36172165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36744714
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13111700
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83915652
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52633289
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.37436228
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88815744
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.53476903
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00468285
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.87812654
10EZH2_22144423_ChIP-Seq_EOC_Human3.33186295
11IGF1R_20145208_ChIP-Seq_DFB_Human3.08141888
12GBX2_23144817_ChIP-Seq_PC3_Human2.96128945
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70075429
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.30582850
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09760007
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09053970
17ZNF274_21170338_ChIP-Seq_K562_Hela2.00793679
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8822576
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94016777
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85401610
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84157587
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82930558
23AR_21572438_ChIP-Seq_LNCaP_Human1.81956422
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80444184
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77797784
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77755332
27* PIAS1_25552417_ChIP-Seq_VCAP_Human1.71487893
28* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68559454
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65288170
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59570262
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55230031
32ER_23166858_ChIP-Seq_MCF-7_Human1.54792665
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53903626
34CLOCK_20551151_ChIP-Seq_293T_Human1.51770278
35* HTT_18923047_ChIP-ChIP_STHdh_Human1.50613165
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.49260546
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45257037
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44382406
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42955281
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39651678
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34465541
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.34045014
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31115512
44GATA1_22025678_ChIP-Seq_K562_Human1.28359860
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28243145
46P300_19829295_ChIP-Seq_ESCs_Human1.27893228
47SMAD4_21799915_ChIP-Seq_A2780_Human1.27377980
48RNF2_27304074_Chip-Seq_NSC_Mouse1.24440551
49STAT3_23295773_ChIP-Seq_U87_Human1.24153988
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23601932
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22738916
52SOX9_26525672_Chip-Seq_HEART_Mouse1.22347992
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21545752
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20052179
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19617002
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19446899
57FUS_26573619_Chip-Seq_HEK293_Human1.17436804
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16665324
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15957991
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15331671
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12975625
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.12882475
63AR_21909140_ChIP-Seq_LNCAP_Human1.11625269
64AR_25329375_ChIP-Seq_VCAP_Human1.10922041
65TCF4_23295773_ChIP-Seq_U87_Human1.10662068
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10482581
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08104184
68TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06920589
69TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06210928
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05284131
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03709264
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03709264
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02950294
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02689817
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.02354456
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01298633
77EWS_26573619_Chip-Seq_HEK293_Human1.00215666
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99733588
79EED_16625203_ChIP-ChIP_MESCs_Mouse0.98410497
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98109402
81* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96937891
82AR_19668381_ChIP-Seq_PC3_Human0.96650518
83* REST_18959480_ChIP-ChIP_MESCs_Mouse0.96430555
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96278160
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95928935
86REST_21632747_ChIP-Seq_MESCs_Mouse0.95591461
87RUNX2_22187159_ChIP-Seq_PCA_Human0.95585341
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94753548
89* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94753299
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.94363124
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93527516
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93400405
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93395823
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93218806
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.92962594
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91910004
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91473085
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91035088
99CBP_20019798_ChIP-Seq_JUKART_Human0.91035088
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90488176
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90465014
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90295488
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89941015
104EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89937733
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87056647
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86339122
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85754806
108ZNF263_19887448_ChIP-Seq_K562_Human0.78617829
109* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77273519
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77271466
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.76227578
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76079164
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75639652
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74759691
115GATA4_25053715_ChIP-Seq_YYC3_Human0.73187926
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73064097
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72870755
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.71380529
119* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70510307
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65141601
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.64026462
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.63915319
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63226362
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.61686827
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.60708223
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59146812
127BCAT_22108803_ChIP-Seq_LS180_Human0.58747333
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58577984
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58577984
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.57279888
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.56624989
132TAF15_26573619_Chip-Seq_HEK293_Human0.55842710
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55547048
134STAT1_17558387_ChIP-Seq_HELA_Human0.54974185
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54913816
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54902287
137CEBPB_22108803_ChIP-Seq_LS180_Human0.54702340
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54428886
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.54327043
140CBP_21632823_ChIP-Seq_H3396_Human0.53543256
141AR_20517297_ChIP-Seq_VCAP_Human0.53231627
142P53_21459846_ChIP-Seq_SAOS-2_Human0.52943026
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52334191
144LXR_22292898_ChIP-Seq_THP-1_Human0.52240940
145MYC_19915707_ChIP-ChIP_AK7_Human0.50568505
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49221755
147* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48809735
148MYC_27129775_Chip-Seq_CORNEA_Mouse0.47328547
149EGR1_19032775_ChIP-ChIP_M12_Human0.47266129
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45819538
151LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.42143842
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42076809
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41085867
154NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.40916157
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40653286
156TAF2_19829295_ChIP-Seq_ESCs_Human0.40601285
157IRF8_22096565_ChIP-ChIP_GC-B_Human0.40552723
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40531661
159GATA1_19941827_ChIP-Seq_MEL_Mouse0.40204944
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.39949214
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.38908126
162* ERG_21242973_ChIP-ChIP_JURKAT_Human0.38818618
163NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.38731651
164NCOR_22424771_ChIP-Seq_293T_Human0.38520157
165ERG_20517297_ChIP-Seq_VCAP_Human0.38313973
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.38078568
167CDX2_22108803_ChIP-Seq_LS180_Human0.38042079
168GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37724534
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.37183294
170GATA1_19941826_ChIP-Seq_K562_Human0.36825918
171EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.36556180
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36445219
173GATA2_19941826_ChIP-Seq_K562_Human0.35870334
174RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.35842377
175PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.35791895
176RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.35419723
177FOXO3_23340844_ChIP-Seq_DLD1_Human0.35369451
178P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35227240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.54175550
2MP0005360_urolithiasis7.52592570
3MP0005085_abnormal_gallbladder_physiolo6.46028368
4MP0005365_abnormal_bile_salt6.29167221
5MP0008875_abnormal_xenobiotic_pharmacok5.05573966
6MP0003252_abnormal_bile_duct4.02122922
7MP0003806_abnormal_nucleotide_metabolis4.01950332
8MP0010329_abnormal_lipoprotein_level3.64827704
9MP0005423_abnormal_somatic_nervous3.22708691
10MP0009840_abnormal_foam_cell3.21947541
11MP0005083_abnormal_biliary_tract3.03518922
12MP0003195_calcinosis2.97164200
13MP0003122_maternal_imprinting2.86431834
14MP0001984_abnormal_olfaction2.75660683
15MP0005332_abnormal_amino_acid2.75393149
16MP0003136_yellow_coat_color2.69576632
17MP0001666_abnormal_nutrient_absorption2.56516489
18MP0003880_abnormal_central_pattern2.49177980
19MP0002736_abnormal_nociception_after2.47569523
20MP0003191_abnormal_cellular_cholesterol2.23385931
21MP0004019_abnormal_vitamin_homeostasis2.21631357
22MP0000609_abnormal_liver_physiology2.16005072
23MP0002118_abnormal_lipid_homeostasis2.12312155
24MP0004270_analgesia2.04851889
25MP0003868_abnormal_feces_composition1.99729790
26MP0000566_synostosis1.94320471
27MP0002138_abnormal_hepatobiliary_system1.93036889
28MP0003011_delayed_dark_adaptation1.92049273
29MP0001529_abnormal_vocalization1.86449417
30MP0005319_abnormal_enzyme/_coenzyme1.78637196
31MP0001968_abnormal_touch/_nociception1.72245088
32MP0001764_abnormal_homeostasis1.71418894
33MP0005499_abnormal_olfactory_system1.71358449
34MP0005394_taste/olfaction_phenotype1.71358449
35MP0003890_abnormal_embryonic-extraembry1.65483904
36MP0008789_abnormal_olfactory_epithelium1.63477838
37MP0006292_abnormal_olfactory_placode1.62627428
38MP0003123_paternal_imprinting1.59599603
39MP0009780_abnormal_chondrocyte_physiolo1.57117076
40MP0005646_abnormal_pituitary_gland1.55606913
41MP0009697_abnormal_copulation1.54615588
42MP0005584_abnormal_enzyme/coenzyme_acti1.53153918
43MP0001486_abnormal_startle_reflex1.39605590
44MP0003121_genomic_imprinting1.39049268
45MP0002734_abnormal_mechanical_nocicepti1.38882286
46MP0000778_abnormal_nervous_system1.37149684
47MP0005451_abnormal_body_composition1.35002077
48MP0005647_abnormal_sex_gland1.29553712
49MP0002638_abnormal_pupillary_reflex1.24904288
50MP0002234_abnormal_pharynx_morphology1.23954737
51MP0003942_abnormal_urinary_system1.20833493
52MP0003656_abnormal_erythrocyte_physiolo1.18000355
53MP0009643_abnormal_urine_homeostasis1.17846393
54MP0002233_abnormal_nose_morphology1.14721748
55MP0000598_abnormal_liver_morphology1.14202412
56MP0004859_abnormal_synaptic_plasticity1.13768610
57MP0002697_abnormal_eye_size1.12040534
58MP0000604_amyloidosis1.10604039
59MP0003115_abnormal_respiratory_system1.09710702
60MP0001986_abnormal_taste_sensitivity1.09522103
61MP0003186_abnormal_redox_activity1.09507252
62MP0003705_abnormal_hypodermis_morpholog1.08842492
63MP0002249_abnormal_larynx_morphology1.07542699
64MP0005253_abnormal_eye_physiology1.06573404
65MP0000955_abnormal_spinal_cord1.04966256
66MP0001915_intracranial_hemorrhage1.02255873
67MP0005171_absent_coat_pigmentation1.00729150
68MP0002254_reproductive_system_inflammat1.00398415
69MP0002282_abnormal_trachea_morphology0.99797973
70MP0002557_abnormal_social/conspecific_i0.99723084
71MP0002572_abnormal_emotion/affect_behav0.97905774
72MP0002653_abnormal_ependyma_morphology0.97251672
73MP0001177_atelectasis0.95972438
74MP0003937_abnormal_limbs/digits/tail_de0.94065040
75MP0009764_decreased_sensitivity_to0.93251627
76MP0009763_increased_sensitivity_to0.93191838
77MP0005391_vision/eye_phenotype0.93141544
78MP0002272_abnormal_nervous_system0.92978803
79MP0003119_abnormal_digestive_system0.92870805
80MP0003755_abnormal_palate_morphology0.92465511
81MP0003635_abnormal_synaptic_transmissio0.91677368
82MP0002064_seizures0.91182476
83MP0000534_abnormal_ureter_morphology0.90674389
84MP0002184_abnormal_innervation0.90337032
85MP0004133_heterotaxia0.90121741
86MP0005636_abnormal_mineral_homeostasis0.89329811
87MP0002063_abnormal_learning/memory/cond0.88361761
88MP0010368_abnormal_lymphatic_system0.87286420
89MP0002938_white_spotting0.87214426
90MP0003385_abnormal_body_wall0.87164492
91MP0005195_abnormal_posterior_eye0.87101874
92MP0005670_abnormal_white_adipose0.86852764
93MP0000049_abnormal_middle_ear0.85490550
94MP0009642_abnormal_blood_homeostasis0.85465343
95MP0005257_abnormal_intraocular_pressure0.85057272
96MP0002089_abnormal_postnatal_growth/wei0.83603978
97MP0002909_abnormal_adrenal_gland0.83406324
98MP0001293_anophthalmia0.83340408
99MP0002152_abnormal_brain_morphology0.82847556
100MP0006276_abnormal_autonomic_nervous0.82084321
101MP0003861_abnormal_nervous_system0.81477220
102MP0002092_abnormal_eye_morphology0.81262651
103MP0005408_hypopigmentation0.80988505
104MP0001661_extended_life_span0.80759348
105MP0002078_abnormal_glucose_homeostasis0.80188408
106MP0002751_abnormal_autonomic_nervous0.80084753
107MP0001286_abnormal_eye_development0.79997092
108MP0003633_abnormal_nervous_system0.79070253
109MP0003632_abnormal_nervous_system0.78781993
110MP0005376_homeostasis/metabolism_phenot0.78213954
111MP0004885_abnormal_endolymph0.78068322
112MP0002067_abnormal_sensory_capabilities0.77454546
113MP0002882_abnormal_neuron_morphology0.77244062
114MP0001270_distended_abdomen0.77236168
115MP0001963_abnormal_hearing_physiology0.76797629
116MP0008877_abnormal_DNA_methylation0.76418728
117MP0002876_abnormal_thyroid_physiology0.76107883
118MP0008469_abnormal_protein_level0.76106785
119MP0009745_abnormal_behavioral_response0.74630998
120MP0002752_abnormal_somatic_nervous0.74585370
121MP0003567_abnormal_fetal_cardiomyocyte0.74447685
122MP0006036_abnormal_mitochondrial_physio0.73509508
123MP0002971_abnormal_brown_adipose0.72981134
124MP0005220_abnormal_exocrine_pancreas0.72879450
125MP0003329_amyloid_beta_deposits0.71157761
126MP0003690_abnormal_glial_cell0.70217590
127MP0005084_abnormal_gallbladder_morpholo0.70208785
128MP0009765_abnormal_xenobiotic_induced0.69330887
129MP0005334_abnormal_fat_pad0.68868147
130MP0004130_abnormal_muscle_cell0.67671024
131MP0005535_abnormal_body_temperature0.67550262
132MP0000639_abnormal_adrenal_gland0.67413667
133MP0009053_abnormal_anal_canal0.65886672
134MP0005266_abnormal_metabolism0.62622106
135MP0001756_abnormal_urination0.61104520
136MP0006035_abnormal_mitochondrial_morpho0.57177007
137MP0005448_abnormal_energy_balance0.56846536
138MP0005395_other_phenotype0.53207507
139MP0005551_abnormal_eye_electrophysiolog0.53033415
140MP0005248_abnormal_Harderian_gland0.51432951
141MP0002928_abnormal_bile_duct0.49098755
142MP0003953_abnormal_hormone_level0.46558113
143MP0009672_abnormal_birth_weight0.44637593
144MP0002090_abnormal_vision0.44066386
145MP0003638_abnormal_response/metabolism_0.42450623
146MP0003718_maternal_effect0.42050436
147MP0009384_cardiac_valve_regurgitation0.41511004
148MP0002136_abnormal_kidney_physiology0.40790614
149MP0002168_other_aberrant_phenotype0.40645967
150MP0002822_catalepsy0.40534244
151MP0005464_abnormal_platelet_physiology0.39799183
152MP0001324_abnormal_eye_pigmentation0.38512933
153MP0005666_abnormal_adipose_tissue0.36716217
154MP0008874_decreased_physiological_sensi0.36529266
155MP0002837_dystrophic_cardiac_calcinosis0.35851165
156MP0004782_abnormal_surfactant_physiolog0.35745048
157MP0000579_abnormal_nail_morphology0.34260125
158MP0008872_abnormal_physiological_respon0.34122128
159MP0008873_increased_physiological_sensi0.33765241
160MP0009115_abnormal_fat_cell0.30870767
161MP0003075_altered_response_to0.30622356
162MP0000230_abnormal_systemic_arterial0.30417428
163MP0005187_abnormal_penis_morphology0.30305257
164MP0005410_abnormal_fertilization0.29835382
165MP0004883_abnormal_blood_vessel0.29310346
166MP0005166_decreased_susceptibility_to0.28935679
167MP0002970_abnormal_white_adipose0.28191291
168MP0000427_abnormal_hair_cycle0.27865598
169MP0004381_abnormal_hair_follicle0.26693660
170MP0002796_impaired_skin_barrier0.25612793
171MP0004043_abnormal_pH_regulation0.24647794
172MP0000249_abnormal_blood_vessel0.23849318
173MP0001243_abnormal_dermal_layer0.23036831
174MP0001881_abnormal_mammary_gland0.22907778
175MP0003699_abnormal_female_reproductive0.22081626
176MP0001944_abnormal_pancreas_morphology0.21454664

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.53567863
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41327598
3Intrahepatic cholestasis (HP:0001406)7.39165570
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.62565798
5Prolonged partial thromboplastin time (HP:0003645)6.59960672
6Hypobetalipoproteinemia (HP:0003563)6.58169567
7Xanthomatosis (HP:0000991)6.32023722
8Hyperlipoproteinemia (HP:0010980)5.66642774
9Complement deficiency (HP:0004431)5.26743623
10Hypolipoproteinemia (HP:0010981)4.97350410
11Joint hemorrhage (HP:0005261)4.73171157
12Hyperammonemia (HP:0001987)4.63129562
13Epidermoid cyst (HP:0200040)4.62455736
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.50574683
15Abnormality of the common coagulation pathway (HP:0010990)4.44787963
16Hyperglycinemia (HP:0002154)4.43987262
17Hypoalphalipoproteinemia (HP:0003233)4.40618690
18Ketosis (HP:0001946)4.35546334
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.23848298
20Abnormality of methionine metabolism (HP:0010901)4.22604491
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09684287
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07051651
23Fat malabsorption (HP:0002630)4.06630041
24Hypoglycemic coma (HP:0001325)3.93732124
25Hyperglycinuria (HP:0003108)3.89653483
26Abnormality of serine family amino acid metabolism (HP:0010894)3.89588843
27Abnormality of glycine metabolism (HP:0010895)3.89588843
28Abnormality of pyrimidine metabolism (HP:0004353)3.78495701
29Abnormality of complement system (HP:0005339)3.78395158
30Conjugated hyperbilirubinemia (HP:0002908)3.77071020
31Abnormality of the intrinsic pathway (HP:0010989)3.71984553
32Hypercholesterolemia (HP:0003124)3.71161504
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37841909
34Hyperbilirubinemia (HP:0002904)3.36343376
35Abnormality of fatty-acid metabolism (HP:0004359)3.31128610
36Hemiparesis (HP:0001269)3.29343012
37Ketoacidosis (HP:0001993)3.10900197
38Delayed CNS myelination (HP:0002188)3.08615796
39Spontaneous abortion (HP:0005268)3.06990392
40Abnormality of serum amino acid levels (HP:0003112)3.02058333
41Abnormality of nucleobase metabolism (HP:0010932)3.01768919
42Hepatocellular carcinoma (HP:0001402)3.00386989
43Steatorrhea (HP:0002570)2.96981922
44Hypochromic microcytic anemia (HP:0004840)2.94482775
45Skin nodule (HP:0200036)2.80093804
46Myocardial infarction (HP:0001658)2.79513012
47Action tremor (HP:0002345)2.75546259
48Metabolic acidosis (HP:0001942)2.72850420
49Hepatoblastoma (HP:0002884)2.69084901
50Acanthocytosis (HP:0001927)2.68828278
51Hypoglycemic seizures (HP:0002173)2.65740499
52Abnormality of purine metabolism (HP:0004352)2.63405528
53Vascular calcification (HP:0004934)2.61548393
54Gait imbalance (HP:0002141)2.57035739
55Systemic lupus erythematosus (HP:0002725)2.54858258
56Lethargy (HP:0001254)2.50632547
57Dicarboxylic aciduria (HP:0003215)2.49952636
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49952636
59Gout (HP:0001997)2.47665495
60Abnormal gallbladder morphology (HP:0012437)2.47221246
61Congenital primary aphakia (HP:0007707)2.45546879
62Abnormal gallbladder physiology (HP:0012438)2.43916678
63Cholecystitis (HP:0001082)2.43916678
64Spastic diplegia (HP:0001264)2.41478873
65Irritability (HP:0000737)2.39095034
66Mitral stenosis (HP:0001718)2.38010844
67Cholelithiasis (HP:0001081)2.37789901
68Glomerulonephritis (HP:0000099)2.33463741
69Cardiovascular calcification (HP:0011915)2.30611993
70Neonatal onset (HP:0003623)2.30106461
71Cerebral edema (HP:0002181)2.26588526
72Supernumerary spleens (HP:0009799)2.26219506
73Malnutrition (HP:0004395)2.23191990
74Amyloidosis (HP:0011034)2.22855916
75Papillary thyroid carcinoma (HP:0002895)2.22444322
76Split foot (HP:0001839)2.21853141
77Vaginal atresia (HP:0000148)2.21449620
78Nephrogenic diabetes insipidus (HP:0009806)2.20882224
79Enlarged kidneys (HP:0000105)2.20268704
80Hemiplegia (HP:0002301)2.20073808
81True hermaphroditism (HP:0010459)2.19316748
82Hyperinsulinemic hypoglycemia (HP:0000825)2.19141381
83Genital tract atresia (HP:0001827)2.18380064
84Bifid scrotum (HP:0000048)2.17295755
85Sensorimotor neuropathy (HP:0007141)2.17199025
86Late onset (HP:0003584)2.16757949
87Alacrima (HP:0000522)2.16544354
88Esophageal varix (HP:0002040)2.15682521
89Brushfield spots (HP:0001088)2.15286215
90Recurrent gram-negative bacterial infections (HP:0005420)2.14008890
91Hyperventilation (HP:0002883)2.13841959
92Gonadal dysgenesis (HP:0000133)2.10890749
93Poikilocytosis (HP:0004447)2.08799898
94Medial flaring of the eyebrow (HP:0010747)2.07744561
95Gingival bleeding (HP:0000225)2.07463646
96Increased serum pyruvate (HP:0003542)2.05845179
97Abnormality of the gallbladder (HP:0005264)2.05624458
98Pancreatitis (HP:0001733)2.04742021
99Thrombophlebitis (HP:0004418)2.01976086
100Menorrhagia (HP:0000132)2.01568123
101Cortical dysplasia (HP:0002539)2.01475686
102Vomiting (HP:0002013)1.99213835
103Hemorrhage of the eye (HP:0011885)1.98695081
104Abnormality of glycolysis (HP:0004366)1.97403463
105Decreased lacrimation (HP:0000633)1.97106604
106Arthropathy (HP:0003040)1.93901341
107Rickets (HP:0002748)1.93311992
108Generalized aminoaciduria (HP:0002909)1.92364066
109Poor coordination (HP:0002370)1.91891840
110Osteomalacia (HP:0002749)1.90934984
111Opisthotonus (HP:0002179)1.90624899
112Status epilepticus (HP:0002133)1.89407117
113Pigmentary retinal degeneration (HP:0001146)1.88026618
114Gastroesophageal reflux (HP:0002020)1.85852136
115Postural tremor (HP:0002174)1.84974650
116Neonatal short-limb short stature (HP:0008921)1.84889906
117Renal cortical cysts (HP:0000803)1.83969536
118Alkalosis (HP:0001948)1.80366248
119Vaginal fistula (HP:0004320)1.80285885
120Abnormal cartilage morphology (HP:0002763)1.79228065
121Elevated hepatic transaminases (HP:0002910)1.78811582
122Hypophosphatemic rickets (HP:0004912)1.78404681
123Broad alveolar ridges (HP:0000187)1.78099565
124Drooling (HP:0002307)1.77712853
125Abnormal enzyme/coenzyme activity (HP:0012379)1.76877833
126Hyperglycemia (HP:0003074)1.76741713
127Abnormality of proline metabolism (HP:0010907)1.76095437
128Hydroxyprolinuria (HP:0003080)1.76095437
129Nephroblastoma (Wilms tumor) (HP:0002667)1.75580026
130Abnormality of transition element cation homeostasis (HP:0011030)1.74781328
131Broad foot (HP:0001769)1.74642130
132Abnormality of vitamin metabolism (HP:0100508)1.72677589
133Embryonal renal neoplasm (HP:0011794)1.71779992
134Gonadotropin excess (HP:0000837)1.71778233
135Symptomatic seizures (HP:0011145)1.71512203
136Abnormality of carpal bone ossification (HP:0006257)1.71507803
137Hypoplastic left heart (HP:0004383)1.71446656
138Abnormal sex determination (HP:0012244)1.71416886
139Sex reversal (HP:0012245)1.71416886
140Termporal pattern (HP:0011008)1.71340239
141Insidious onset (HP:0003587)1.71340239
142Meckel diverticulum (HP:0002245)1.71135663
143Retinal dysplasia (HP:0007973)1.69022004
144Small epiphyses (HP:0010585)1.66728108
145Abnormality of the corticospinal tract (HP:0002492)1.65921984
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64167173
147Megalencephaly (HP:0001355)1.63290539
148Abnormality of the ileum (HP:0001549)1.62266468
149Renal hypoplasia (HP:0000089)1.62104322
150Abnormality of the lower motor neuron (HP:0002366)1.61451040
151Abnormal biliary tract physiology (HP:0012439)1.61233466
152Bile duct proliferation (HP:0001408)1.61233466
153Oligodactyly (hands) (HP:0001180)1.60355798
154Trigonocephaly (HP:0000243)1.57628138
155Abnormality of the nasal septum (HP:0000419)1.56412852
156Absent epiphyses (HP:0010577)1.54262645
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54262645
158Bronchomalacia (HP:0002780)1.53108853
159Morphological abnormality of the inner ear (HP:0011390)1.52899662
160Oligodactyly (HP:0012165)1.52136396
161Facial hemangioma (HP:0000329)1.51270117
162Transposition of the great arteries (HP:0001669)1.51132965
163Abnormal connection of the cardiac segments (HP:0011545)1.51132965
164Abnormal ventriculo-arterial connection (HP:0011563)1.51132965
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.50817931
166Chromsome breakage (HP:0040012)1.50762652
167Thyroid carcinoma (HP:0002890)1.50371627
168Nephritis (HP:0000123)1.50256799
169Excessive salivation (HP:0003781)1.49284667
170Cutaneous finger syndactyly (HP:0010554)1.47684317
171Urinary urgency (HP:0000012)1.47523302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.75833587
2SIK14.65373116
3FGFR44.44627660
4ERN14.11785579
5CASK4.03917204
6MARK13.28565065
7INSRR3.19276760
8TAOK32.78831625
9ERBB42.76989791
10NTRK22.63583616
11MAP2K42.50414218
12PNCK2.39429119
13CCNB12.16252276
14PKN22.14895743
15TRIB31.99504994
16LATS11.95491866
17MST1R1.82591203
18FGFR21.80062352
19MAPK111.74082941
20PRKD31.71255172
21DAPK21.70719644
22PIK3CA1.70410357
23NEK11.67626122
24PLK21.67144714
25BCR1.64296641
26PIK3CG1.62084666
27FLT31.55870895
28PTK61.55615909
29WEE11.44143695
30PINK11.43691768
31NTRK31.38845646
32WNK41.34615080
33ERBB31.32427091
34PDK41.32032928
35PDK31.32032928
36TYK21.29296722
37MAP3K101.28238523
38ICK1.27326876
39FRK1.27077965
40ERBB21.26514052
41ABL21.22585604
42BMPR1B1.21370047
43MAPK131.20227661
44PLK41.18620760
45PRKAA21.14976718
46DYRK21.14600248
47TTK1.12431030
48MAP3K71.11841812
49NEK61.11276138
50PRKCZ1.10631810
51NEK91.08915502
52MAPK151.04615138
53JAK21.03940653
54MKNK21.02917416
55STK38L1.01762434
56EIF2AK11.00538600
57CAMK1D0.99019705
58BRSK10.96761889
59SRPK10.95745002
60MAPK40.92061726
61KDR0.91832489
62DYRK1B0.91083851
63SGK30.90999123
64TSSK60.89355760
65GRK10.88114217
66PRKACG0.86364502
67MAP2K70.85701214
68PRKAA10.84605032
69SGK20.83629065
70MAPK120.81368204
71BRSK20.80919139
72MINK10.78929964
73PAK60.77658668
74SGK10.77475974
75CDK60.76364848
76RIPK10.75111400
77TNIK0.74532944
78JAK10.74504726
79PRKCE0.74380984
80GRK60.72911922
81MET0.72880437
82CSNK1D0.72762302
83CAMK1G0.72626584
84GSK3A0.72618263
85STK390.72422691
86CDK30.72039968
87SGK4940.71205444
88SGK2230.71205444
89CDK80.68946435
90RPS6KB10.68712877
91ATM0.67422993
92FGFR30.66962119
93CDK70.66398607
94PLK30.66233748
95TBK10.65090633
96PRKDC0.63981135
97CSNK1E0.63320316
98CDK150.63119769
99MAP4K20.62590920
100CDK180.62212787
101EPHB10.61970367
102CDC70.60661814
103KSR10.60437347
104SIK20.59849649
105MAPK70.59840466
106CAMK2G0.59742647
107MAP3K40.59544040
108EPHA40.59274974
109PLK10.59070108
110EPHA30.58933054
111MAP2K60.58197183
112CAMK2B0.57789872
113PTK20.56917668
114MAP2K30.56882884
115PRKCG0.56847561
116MTOR0.55766444
117BRD40.55013607
118RET0.54455462
119PDK20.54368126
120CDK11A0.53182478
121ATR0.52704604
122CDK140.52413627
123CSNK1G10.51766016
124YES10.51409037
125DYRK1A0.51227882
126TRIM280.50921417
127WNK30.50824099
128MAP3K30.49822413
129CSK0.49795363
130TIE10.48419858
131IRAK20.47882679
132CDK50.47600401
133MAP3K140.47447023
134PDPK10.46822161
135PBK0.43946017
136MAP3K110.43906855
137TYRO30.43601552
138CSNK1G20.43459450
139CDK40.42518700
140IGF1R0.40651801
141MAP3K50.38812058
142PRKCQ0.38649438
143TAOK20.38642152
144CAMK40.36349115
145FGFR10.35330112
146EGFR0.34151893
147PAK30.33234381
148CSF1R0.32660606
149LATS20.32063158
150PDK10.31938581
151PKN10.30939594
152MAP2K10.29955553
153PDGFRA0.29722669
154CSNK1G30.29009414
155STK380.28830909
156CSNK1A1L0.28477750
157AKT30.26903672
158PRKCA0.25520060

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48506689
2Nitrogen metabolism_Homo sapiens_hsa009103.77256091
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39157519
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34685891
5Arginine biosynthesis_Homo sapiens_hsa002203.02570275
6Complement and coagulation cascades_Homo sapiens_hsa046102.75678014
7Tryptophan metabolism_Homo sapiens_hsa003802.67377789
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64000052
9* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62686022
10Fatty acid degradation_Homo sapiens_hsa000712.59146671
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50031586
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38821132
13Butanoate metabolism_Homo sapiens_hsa006502.22391309
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20108673
15Peroxisome_Homo sapiens_hsa041462.08908897
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07790305
17Propanoate metabolism_Homo sapiens_hsa006402.01760665
18PPAR signaling pathway_Homo sapiens_hsa033201.97437379
19Chemical carcinogenesis_Homo sapiens_hsa052041.89442450
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.89439112
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85889233
22* Fatty acid metabolism_Homo sapiens_hsa012121.85881598
23Histidine metabolism_Homo sapiens_hsa003401.82999745
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75214277
25Retinol metabolism_Homo sapiens_hsa008301.71844027
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71309086
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70212611
28beta-Alanine metabolism_Homo sapiens_hsa004101.69524094
29Staphylococcus aureus infection_Homo sapiens_hsa051501.66199674
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65104130
31Selenocompound metabolism_Homo sapiens_hsa004501.62361935
32Caffeine metabolism_Homo sapiens_hsa002321.58646442
33Bile secretion_Homo sapiens_hsa049761.55974668
34Phenylalanine metabolism_Homo sapiens_hsa003601.50946840
35Pyruvate metabolism_Homo sapiens_hsa006201.48842933
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47478879
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41153106
38Tyrosine metabolism_Homo sapiens_hsa003501.38776553
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.31577588
40Sulfur metabolism_Homo sapiens_hsa009201.28714031
41Starch and sucrose metabolism_Homo sapiens_hsa005001.25246071
42ABC transporters_Homo sapiens_hsa020101.24525286
43Steroid biosynthesis_Homo sapiens_hsa001001.21348952
44Fat digestion and absorption_Homo sapiens_hsa049751.21298794
45Biosynthesis of amino acids_Homo sapiens_hsa012301.19180227
46Carbon metabolism_Homo sapiens_hsa012001.14054191
47* Fatty acid elongation_Homo sapiens_hsa000621.12222372
48Folate biosynthesis_Homo sapiens_hsa007901.09852695
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.09279298
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00644508
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97706587
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94879952
53Vitamin B6 metabolism_Homo sapiens_hsa007500.94108339
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.93495584
55Lysine degradation_Homo sapiens_hsa003100.92814709
56Arginine and proline metabolism_Homo sapiens_hsa003300.92657713
57Vitamin digestion and absorption_Homo sapiens_hsa049770.92172526
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88017676
59Sulfur relay system_Homo sapiens_hsa041220.87843287
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84527968
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81709521
62Nicotine addiction_Homo sapiens_hsa050330.78094459
63Protein export_Homo sapiens_hsa030600.77138390
64Fatty acid biosynthesis_Homo sapiens_hsa000610.76919451
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76726293
66N-Glycan biosynthesis_Homo sapiens_hsa005100.75275742
67Glycerolipid metabolism_Homo sapiens_hsa005610.74870857
68GABAergic synapse_Homo sapiens_hsa047270.71405144
69One carbon pool by folate_Homo sapiens_hsa006700.69517323
70Glutathione metabolism_Homo sapiens_hsa004800.59578868
71Fanconi anemia pathway_Homo sapiens_hsa034600.56227674
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55749555
73Pentose phosphate pathway_Homo sapiens_hsa000300.55347612
74Glutamatergic synapse_Homo sapiens_hsa047240.51677393
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47974813
76Circadian rhythm_Homo sapiens_hsa047100.46751174
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44489608
78Metabolic pathways_Homo sapiens_hsa011000.44315887
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40421561
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35312356
81Prion diseases_Homo sapiens_hsa050200.33881339
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32380258
83Axon guidance_Homo sapiens_hsa043600.30761938
84Hippo signaling pathway_Homo sapiens_hsa043900.30453040
85TGF-beta signaling pathway_Homo sapiens_hsa043500.29291473
86Dopaminergic synapse_Homo sapiens_hsa047280.28610387
87Insulin resistance_Homo sapiens_hsa049310.26883050
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26659332
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.26129318
90Circadian entrainment_Homo sapiens_hsa047130.25388139
91Cocaine addiction_Homo sapiens_hsa050300.24299112
92Basal cell carcinoma_Homo sapiens_hsa052170.23888519
93Fructose and mannose metabolism_Homo sapiens_hsa000510.23342462
94Amphetamine addiction_Homo sapiens_hsa050310.22875679
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22332533
96Galactose metabolism_Homo sapiens_hsa000520.22257308
97Base excision repair_Homo sapiens_hsa034100.21851529
98Linoleic acid metabolism_Homo sapiens_hsa005910.21442506
99Choline metabolism in cancer_Homo sapiens_hsa052310.21344117
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.20825671
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20330227
102Glucagon signaling pathway_Homo sapiens_hsa049220.20270035
103Oocyte meiosis_Homo sapiens_hsa041140.18473641
104Mineral absorption_Homo sapiens_hsa049780.16525104
105AMPK signaling pathway_Homo sapiens_hsa041520.07263112
106Type II diabetes mellitus_Homo sapiens_hsa04930-0.2182714
107Renin-angiotensin system_Homo sapiens_hsa04614-0.2164047
108Hepatitis C_Homo sapiens_hsa05160-0.2093985
109Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2062918
110Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1953479
111African trypanosomiasis_Homo sapiens_hsa05143-0.1932191
112Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1929776
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1755875
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1736472
115Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1643687
116Regulation of autophagy_Homo sapiens_hsa04140-0.1626475
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1590352
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1581585
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1578181
120Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1339642
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1327790
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1164717
123Phototransduction_Homo sapiens_hsa04744-0.0644101
124Insulin signaling pathway_Homo sapiens_hsa04910-0.0607345
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0445657
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0145582

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