ELOVL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1linoleic acid metabolic process (GO:0043651)9.72398047
2hair follicle morphogenesis (GO:0031069)8.22106037
3intermediate filament cytoskeleton organization (GO:0045104)7.83531990
4intermediate filament-based process (GO:0045103)7.60288393
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46675074
6L-phenylalanine catabolic process (GO:0006559)7.46675074
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11467450
8L-phenylalanine metabolic process (GO:0006558)7.11467450
9aromatic amino acid family catabolic process (GO:0009074)7.01737370
10keratinocyte proliferation (GO:0043616)6.74097330
11tryptophan catabolic process (GO:0006569)6.66443455
12indole-containing compound catabolic process (GO:0042436)6.66443455
13indolalkylamine catabolic process (GO:0046218)6.66443455
14multicellular organismal water homeostasis (GO:0050891)6.62584536
15bile acid biosynthetic process (GO:0006699)6.59297739
16peptide cross-linking (GO:0018149)6.55050576
17kynurenine metabolic process (GO:0070189)6.46126927
18retinol metabolic process (GO:0042572)6.44607451
19epidermis development (GO:0008544)6.36629388
20tryptophan metabolic process (GO:0006568)6.22278712
21glyoxylate metabolic process (GO:0046487)6.11065424
22complement activation, alternative pathway (GO:0006957)6.08340699
23keratinocyte differentiation (GO:0030216)6.06129550
24regulation of protein activation cascade (GO:2000257)5.92164202
25regulation of sequestering of triglyceride (GO:0010889)5.90227385
26alpha-linolenic acid metabolic process (GO:0036109)5.85390172
27long-chain fatty acid biosynthetic process (GO:0042759)5.75851757
28water homeostasis (GO:0030104)5.73400123
29regulation of complement activation (GO:0030449)5.67038677
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64452706
31urea cycle (GO:0000050)5.64452492
32urea metabolic process (GO:0019627)5.64452492
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.55055773
34* fatty acid elongation (GO:0030497)5.50105647
35cysteine metabolic process (GO:0006534)5.44367358
36sulfur amino acid catabolic process (GO:0000098)5.41222700
37negative regulation of fibrinolysis (GO:0051918)5.39966938
38regulation of fibrinolysis (GO:0051917)5.33109658
39bile acid metabolic process (GO:0008206)5.30358653
40protein carboxylation (GO:0018214)5.25503013
41peptidyl-glutamic acid carboxylation (GO:0017187)5.25503013
42nitrogen cycle metabolic process (GO:0071941)5.19354625
43lipoxygenase pathway (GO:0019372)5.08176399
44aromatic amino acid family metabolic process (GO:0009072)5.07763588
45molting cycle process (GO:0022404)5.03421344
46hair cycle process (GO:0022405)5.03421344
47high-density lipoprotein particle remodeling (GO:0034375)5.00899044
48serine family amino acid catabolic process (GO:0009071)5.00846686
49* long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.00416670
50primary alcohol metabolic process (GO:0034308)5.00269909
51epidermal cell differentiation (GO:0009913)4.92439829
52homocysteine metabolic process (GO:0050667)4.92373766
53coenzyme catabolic process (GO:0009109)4.85559181
54cytolysis (GO:0019835)4.84897009
55regulation of triglyceride catabolic process (GO:0010896)4.83234694
56lysine catabolic process (GO:0006554)4.75089466
57lysine metabolic process (GO:0006553)4.75089466
58indolalkylamine metabolic process (GO:0006586)4.69411870
59tyrosine metabolic process (GO:0006570)4.63324496
60alpha-amino acid catabolic process (GO:1901606)4.62555311
61low-density lipoprotein particle clearance (GO:0034383)4.61834931
62amine catabolic process (GO:0009310)4.59713773
63cellular biogenic amine catabolic process (GO:0042402)4.59713773
64bile acid and bile salt transport (GO:0015721)4.56569153
65glycine metabolic process (GO:0006544)4.54232475
66acylglycerol homeostasis (GO:0055090)4.51219129
67triglyceride homeostasis (GO:0070328)4.51219129
68ethanol oxidation (GO:0006069)4.50644973
69* very long-chain fatty acid metabolic process (GO:0000038)4.50561562
70amino-acid betaine metabolic process (GO:0006577)4.50021312
71phosphatidylserine acyl-chain remodeling (GO:0036150)4.48104033
72positive regulation of chemokine secretion (GO:0090197)4.39881936
73reverse cholesterol transport (GO:0043691)4.37744766
74protein-lipid complex remodeling (GO:0034368)4.35394522
75macromolecular complex remodeling (GO:0034367)4.35394522
76plasma lipoprotein particle remodeling (GO:0034369)4.35394522
77imidazole-containing compound metabolic process (GO:0052803)4.34844572
78positive regulation of keratinocyte differentiation (GO:0045618)4.31601435
79hemidesmosome assembly (GO:0031581)4.30580901
80serine family amino acid metabolic process (GO:0009069)4.28421400
81cellular amino acid catabolic process (GO:0009063)4.27486847
82complement activation, classical pathway (GO:0006958)4.23604988
83regulation of cholesterol esterification (GO:0010872)4.21731813
84phospholipid efflux (GO:0033700)4.20860338
85benzene-containing compound metabolic process (GO:0042537)4.20667440
86glutamate metabolic process (GO:0006536)4.19417998
87dicarboxylic acid biosynthetic process (GO:0043650)4.18895732
88cellular ketone body metabolic process (GO:0046950)4.18467780
89regulation of chemokine secretion (GO:0090196)4.17609168
90acetyl-CoA metabolic process (GO:0006084)4.16888312
91cellular glucuronidation (GO:0052695)4.12376886
92complement activation (GO:0006956)4.11988387
93cellular modified amino acid catabolic process (GO:0042219)4.11607999
94* fatty-acyl-CoA metabolic process (GO:0035337)4.11397333
95plasma lipoprotein particle clearance (GO:0034381)4.10804772
96serine family amino acid biosynthetic process (GO:0009070)4.09981711
97response to phenylpropanoid (GO:0080184)4.06638456
98negative regulation of cholesterol transport (GO:0032375)4.04353933
99negative regulation of sterol transport (GO:0032372)4.04353933
100fibrinolysis (GO:0042730)4.03755981
101bundle of His cell to Purkinje myocyte communication (GO:0086069)4.03593568
102aldehyde catabolic process (GO:0046185)3.94467972
103cofactor catabolic process (GO:0051187)3.91683280
104protein activation cascade (GO:0072376)3.91645791
105cholesterol efflux (GO:0033344)3.89901754
106arginine metabolic process (GO:0006525)3.85408060
107blood coagulation, intrinsic pathway (GO:0007597)3.78062294
108organic acid catabolic process (GO:0016054)3.76129354
109carboxylic acid catabolic process (GO:0046395)3.76129354
110phosphatidylinositol acyl-chain remodeling (GO:0036149)3.75807028
111very-low-density lipoprotein particle assembly (GO:0034379)3.74931319
112plasma lipoprotein particle assembly (GO:0034377)3.73187263
113phospholipid homeostasis (GO:0055091)3.72050378
114regulation of cholesterol homeostasis (GO:2000188)3.70873686
115carnitine metabolic process (GO:0009437)3.68669026
116low-density lipoprotein particle remodeling (GO:0034374)3.66588362
117uronic acid metabolic process (GO:0006063)3.65613133
118glucuronate metabolic process (GO:0019585)3.65613133
119NAD biosynthetic process (GO:0009435)3.62305148
120* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.62046312
121ketone body metabolic process (GO:1902224)3.61932355
122pyridine nucleotide biosynthetic process (GO:0019363)3.61883850
123nicotinamide nucleotide biosynthetic process (GO:0019359)3.61883850
124positive regulation of epidermal cell differentiation (GO:0045606)3.60145975
125cholesterol homeostasis (GO:0042632)3.59070201
126positive regulation of lipid catabolic process (GO:0050996)3.58462039
127fatty acid beta-oxidation (GO:0006635)3.57289567
128fatty acid oxidation (GO:0019395)3.56896742
129response to nitrosative stress (GO:0051409)3.56783262
130positive regulation of triglyceride lipase activity (GO:0061365)3.55808043
131positive regulation of lipoprotein lipase activity (GO:0051006)3.55808043
132short-chain fatty acid metabolic process (GO:0046459)3.53951830
133sterol homeostasis (GO:0055092)3.53048763
134monocarboxylic acid catabolic process (GO:0072329)3.52849380
135* fatty-acyl-CoA biosynthetic process (GO:0046949)3.51920320
136* triglyceride biosynthetic process (GO:0019432)3.48730011
137lipid storage (GO:0019915)3.47067156
138regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.45679796
139phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.45583436
140primary alcohol catabolic process (GO:0034310)3.45186665
141skin morphogenesis (GO:0043589)3.39592512
142phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.38635393
143* neutral lipid biosynthetic process (GO:0046460)3.26997077
144* acylglycerol biosynthetic process (GO:0046463)3.26997077
145epithelial cell differentiation involved in prostate gland development (GO:0060742)3.26487269
146phosphatidylcholine acyl-chain remodeling (GO:0036151)3.21605099
147negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.21561041
148phosphatidic acid metabolic process (GO:0046473)3.21039189
149phosphatidic acid biosynthetic process (GO:0006654)3.21039189
150regulation of keratinocyte differentiation (GO:0045616)3.13062590
151* acyl-CoA biosynthetic process (GO:0071616)3.10944957
152* thioester biosynthetic process (GO:0035384)3.10944957
153fatty acid homeostasis (GO:0055089)3.09241147
154regulation of defense response to virus by host (GO:0050691)3.08070236
155positive regulation of epidermis development (GO:0045684)3.04987791
156defense response to fungus (GO:0050832)3.03535991
157molting cycle (GO:0042303)23.9934878
158hair cycle (GO:0042633)23.9934878
159negative regulation of execution phase of apoptosis (GO:1900118)2.94620288
160* acyl-CoA metabolic process (GO:0006637)2.94349329
161* thioester metabolic process (GO:0035383)2.94349329
162unsaturated fatty acid biosynthetic process (GO:0006636)2.92805087
163epithelium development (GO:0060429)2.92141148
164adhesion of symbiont to host cell (GO:0044650)2.81607770
165virion attachment to host cell (GO:0019062)2.81607770
166positive regulation of lipid storage (GO:0010884)2.81603998
167regulation of phospholipase A2 activity (GO:0032429)2.81265007
168ethanol metabolic process (GO:0006067)2.80462959
169phosphatidylserine metabolic process (GO:0006658)2.78825805
170disruption of cells of other organism (GO:0044364)2.78460030
171killing of cells of other organism (GO:0031640)2.78460030
172regulation of retinoic acid receptor signaling pathway (GO:0048385)2.72126952
173positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.63612394
174hair follicle development (GO:0001942)2.61665641
175adhesion of symbiont to host (GO:0044406)2.52850173
176alditol phosphate metabolic process (GO:0052646)2.52116290
177triglyceride catabolic process (GO:0019433)2.49036865
178polarized epithelial cell differentiation (GO:0030859)2.48303966
179oocyte development (GO:0048599)2.43061600
180negative regulation of keratinocyte proliferation (GO:0010839)2.40474133
181regulation of epidermal cell differentiation (GO:0045604)2.37412711
182ectoderm development (GO:0007398)2.36864864
183response to insecticide (GO:0017085)2.27569753
184regulation of hypersensitivity (GO:0002883)2.25402370
185CDP-diacylglycerol biosynthetic process (GO:0016024)2.24996915
186one-carbon compound transport (GO:0019755)2.23027663
187negative regulation of lipase activity (GO:0060192)2.21888997
188CDP-diacylglycerol metabolic process (GO:0046341)2.21014937
189glycerol metabolic process (GO:0006071)2.17097262
190alditol metabolic process (GO:0019400)2.14737715
191detection of bacterium (GO:0016045)2.14304191
192intermediate filament organization (GO:0045109)13.0067521
193establishment of skin barrier (GO:0061436)11.8333542
194keratinization (GO:0031424)11.5244909
195regulation of water loss via skin (GO:0033561)10.2781194
196desmosome organization (GO:0002934)10.1657165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.88743920
2RXR_22158963_ChIP-Seq_LIVER_Mouse8.21001656
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.22380931
4PPARA_22158963_ChIP-Seq_LIVER_Mouse7.17357263
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.40612674
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24232015
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84841224
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81701409
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.53021312
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.12298743
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.73935366
12P63_26484246_Chip-Seq_KERATINOCYTES_Human3.21016448
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.68675078
14EZH2_22144423_ChIP-Seq_EOC_Human2.28828354
15SOX9_24532713_ChIP-Seq_HFSC_Mouse2.22940185
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09207872
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01850109
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00403500
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8780955
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95039374
21CTCF_20526341_ChIP-Seq_ESCs_Human1.82450196
22TP63_22573176_ChIP-Seq_HFKS_Human1.71389554
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.58781991
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.58508855
25CLOCK_20551151_ChIP-Seq_293T_Human1.58003600
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54631842
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54631842
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51194565
29* BCOR_27268052_Chip-Seq_Bcells_Human1.48965638
30* HTT_18923047_ChIP-ChIP_STHdh_Human1.48526893
31GATA1_22025678_ChIP-Seq_K562_Human1.45914572
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.43717355
33SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41692377
34BCL6_27268052_Chip-Seq_Bcells_Human1.41210283
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.35869211
36* E2F1_20622854_ChIP-Seq_HELA_Human1.34809258
37TP63_23658742_ChIP-Seq_EP156T_Human1.34625316
38* P68_20966046_ChIP-Seq_HELA_Human1.26865125
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26214704
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22729001
41RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20207421
42RACK7_27058665_Chip-Seq_MCF-7_Human1.12032589
43* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09915271
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07597963
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.06350688
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05254682
47RXR_22108803_ChIP-Seq_LS180_Human1.05031731
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.02992637
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02275746
50PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00714523
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99474718
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99452083
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98221154
54HNFA_21074721_ChIP-Seq_CACO-2_Human0.97568744
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96696217
56SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96427606
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96022122
58KLF5_25053715_ChIP-Seq_YYC3_Human0.96019312
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95859028
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94669485
61CTCF_27219007_Chip-Seq_Bcells_Human0.94474022
62* FOXH1_21741376_ChIP-Seq_ESCs_Human0.93592198
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92838220
64SMC4_20622854_ChIP-Seq_HELA_Human0.91600597
65SA1_27219007_Chip-Seq_ERYTHROID_Human0.90937112
66PHF8_20622853_ChIP-Seq_HELA_Human0.90314891
67ATF3_27146783_Chip-Seq_COLON_Human0.89805038
68RBPJ_21746931_ChIP-Seq_IB4_Human0.89115433
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88831631
70TP53_20018659_ChIP-ChIP_R1E_Mouse0.88827841
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88445744
72RUNX1_27514584_Chip-Seq_MCF-7_Human0.88180389
73ZNF263_19887448_ChIP-Seq_K562_Human0.87483714
74PHF8_20622854_ChIP-Seq_HELA_Human0.87046759
75* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86948297
76* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84698628
77* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83600828
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82388982
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81405252
80TBX20_22328084_ChIP-Seq_HEART_Mouse0.81334929
81TBX20_22080862_ChIP-Seq_HEART_Mouse0.81334929
82GATA4_25053715_ChIP-Seq_YYC3_Human0.81145812
83TBL1_22424771_ChIP-Seq_293T_Human0.80522618
84AR_21572438_ChIP-Seq_LNCaP_Human0.78606310
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78586991
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78475000
87TRIM28_21343339_ChIP-Seq_HEK293_Human0.78344837
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77956499
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77613448
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77576746
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.77558838
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76798885
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.76541080
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75467686
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.75216169
96P300_27268052_Chip-Seq_Bcells_Human0.74309317
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74301500
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74301500
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74163435
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73896072
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73801832
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73448688
103* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71685338
104FOXA1_25329375_ChIP-Seq_VCAP_Human0.71465479
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71465479
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70895151
107RARA_24833708_ChIP-Seq_LIVER_Mouse0.69396682
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.69093663
109EGR1_19032775_ChIP-ChIP_M12_Human0.68871652
110* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.68851817
111SA1_27219007_Chip-Seq_Bcells_Human0.68549379
112SMAD4_21741376_ChIP-Seq_ESCs_Human0.68300565
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67874566
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67412790
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.64454445
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.64142735
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62432432
118CEBPB_22108803_ChIP-Seq_LS180_Human0.61272036
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60490342
120TAF15_26573619_Chip-Seq_HEK293_Human0.59404447
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57946114
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57905173
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57374663
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.56766715
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56403950
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56383433
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56038090
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55568212
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.54497634
130AR_20517297_ChIP-Seq_VCAP_Human0.54335443
131MYC_19915707_ChIP-ChIP_AK7_Human0.53604628
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52406119
133BCAT_22108803_ChIP-Seq_LS180_Human0.51166462
134* FOXO3_23340844_ChIP-Seq_DLD1_Human0.50206122
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.49886485
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49744802
137TAF2_19829295_ChIP-Seq_ESCs_Human0.49510019
138P53_21459846_ChIP-Seq_SAOS-2_Human0.48656669
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.48438683
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48154253
141LXR_22292898_ChIP-Seq_THP-1_Human0.47916488
142ERG_20517297_ChIP-Seq_VCAP_Human0.47402392
143* CBP_21632823_ChIP-Seq_H3396_Human0.47297496
144* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45147972
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43385593
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43196125
147STAT1_17558387_ChIP-Seq_HELA_Human0.42219132
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41848519
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41696676
150GATA6_25053715_ChIP-Seq_YYC3_Human0.41327228
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.39868050
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39517180
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.39286282
154BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.38564012
155FOXH1_21741376_ChIP-Seq_EPCs_Human0.38212973
156GATA2_19941826_ChIP-Seq_K562_Human0.37640109
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37130136
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.36742912
159NCOR_22424771_ChIP-Seq_293T_Human0.36369271
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.36129682
161SPI1_26923725_Chip-Seq_HPCs_Mouse0.35724411
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35693168
163TP63_17297297_ChIP-ChIP_HaCaT_Human0.34929189
164SOX2_20726797_ChIP-Seq_SW620_Human0.34823934
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34495171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29950217
2MP0005360_urolithiasis7.39877109
3MP0005085_abnormal_gallbladder_physiolo6.63037432
4MP0005365_abnormal_bile_salt6.41045194
5* MP0000647_abnormal_sebaceous_gland5.24240053
6MP0008875_abnormal_xenobiotic_pharmacok4.49699962
7MP0003806_abnormal_nucleotide_metabolis4.42080084
8MP0003252_abnormal_bile_duct4.16795861
9MP0001188_hyperpigmentation3.96950072
10MP0010329_abnormal_lipoprotein_level3.56052235
11* MP0005501_abnormal_skin_physiology3.44478296
12* MP0000377_abnormal_hair_follicle2.98113034
13MP0005083_abnormal_biliary_tract2.97100878
14MP0009840_abnormal_foam_cell2.87569734
15MP0001666_abnormal_nutrient_absorption2.68217077
16MP0005332_abnormal_amino_acid2.63349094
17* MP0001216_abnormal_epidermal_layer2.62200298
18MP0003195_calcinosis2.56890855
19MP0010678_abnormal_skin_adnexa2.56395909
20MP0002095_abnormal_skin_pigmentation2.47581436
21MP0003191_abnormal_cellular_cholesterol2.19823753
22MP0000609_abnormal_liver_physiology2.17441135
23* MP0010771_integument_phenotype2.17273005
24MP0000383_abnormal_hair_follicle2.16845049
25MP0002118_abnormal_lipid_homeostasis2.12212438
26MP0005409_darkened_coat_color2.07856313
27MP0003868_abnormal_feces_composition2.07311768
28MP0004019_abnormal_vitamin_homeostasis2.01681362
29MP0002138_abnormal_hepatobiliary_system1.95764034
30* MP0004947_skin_inflammation1.94575386
31MP0000566_synostosis1.91529109
32MP0000015_abnormal_ear_pigmentation1.89004753
33MP0005319_abnormal_enzyme/_coenzyme1.84515713
34MP0009931_abnormal_skin_appearance1.77641338
35* MP0004381_abnormal_hair_follicle1.75817484
36* MP0000367_abnormal_coat/_hair1.68929462
37MP0003011_delayed_dark_adaptation1.65228867
38MP0001764_abnormal_homeostasis1.60765116
39MP0003300_gastrointestinal_ulcer1.59682246
40MP0009697_abnormal_copulation1.55424052
41MP0005584_abnormal_enzyme/coenzyme_acti1.54253381
42MP0005174_abnormal_tail_pigmentation1.52357031
43MP0003705_abnormal_hypodermis_morpholog1.47162811
44MP0003878_abnormal_ear_physiology1.39253822
45MP0005377_hearing/vestibular/ear_phenot1.39253822
46MP0004185_abnormal_adipocyte_glucose1.35378692
47MP0005647_abnormal_sex_gland1.29881469
48MP0003941_abnormal_skin_development1.26473797
49MP0005451_abnormal_body_composition1.23313897
50MP0003186_abnormal_redox_activity1.21439892
51MP0001191_abnormal_skin_condition1.14717478
52MP0000598_abnormal_liver_morphology1.14657021
53MP0009643_abnormal_urine_homeostasis1.14259753
54MP0003656_abnormal_erythrocyte_physiolo1.13250279
55MP0002254_reproductive_system_inflammat1.10488136
56MP0000579_abnormal_nail_morphology1.04743003
57MP0004885_abnormal_endolymph1.00608323
58MP0010368_abnormal_lymphatic_system0.99934494
59MP0009764_decreased_sensitivity_to0.99930815
60MP0010030_abnormal_orbit_morphology0.95485432
61MP0009763_increased_sensitivity_to0.95054671
62MP0000604_amyloidosis0.92318477
63MP0005636_abnormal_mineral_homeostasis0.87872079
64MP0008469_abnormal_protein_level0.87512836
65MP0005408_hypopigmentation0.84199839
66MP0004858_abnormal_nervous_system0.82824135
67MP0009642_abnormal_blood_homeostasis0.82434938
68MP0006036_abnormal_mitochondrial_physio0.81962529
69MP0004130_abnormal_muscle_cell0.81299993
70MP0000762_abnormal_tongue_morphology0.80856778
71MP0005220_abnormal_exocrine_pancreas0.80829081
72MP0005084_abnormal_gallbladder_morpholo0.78707400
73MP0005376_homeostasis/metabolism_phenot0.78090340
74MP0002078_abnormal_glucose_homeostasis0.75750694
75* MP0002796_impaired_skin_barrier0.75540464
76MP0002876_abnormal_thyroid_physiology0.75208221
77MP0000569_abnormal_digit_pigmentation0.73239905
78MP0002971_abnormal_brown_adipose0.72824106
79MP0005670_abnormal_white_adipose0.72358194
80MP0005334_abnormal_fat_pad0.71872818
81MP0003566_abnormal_cell_adhesion0.71226256
82MP0009765_abnormal_xenobiotic_induced0.70784748
83MP0009384_cardiac_valve_regurgitation0.67650412
84MP0009379_abnormal_foot_pigmentation0.67520720
85MP0005266_abnormal_metabolism0.67497106
86MP0006035_abnormal_mitochondrial_morpho0.64394263
87* MP0005535_abnormal_body_temperature0.63611822
88MP0009053_abnormal_anal_canal0.61409117
89MP0003690_abnormal_glial_cell0.60322423
90MP0002177_abnormal_outer_ear0.59239806
91MP0001661_extended_life_span0.58123116
92MP0000427_abnormal_hair_cycle0.57894334
93MP0000639_abnormal_adrenal_gland0.54848816
94MP0005375_adipose_tissue_phenotype0.54795925
95MP0003329_amyloid_beta_deposits0.54073418
96MP0005448_abnormal_energy_balance0.54069700
97MP0001851_eye_inflammation0.52637775
98MP0002928_abnormal_bile_duct0.51056519
99MP0001756_abnormal_urination0.51024920
100MP0002060_abnormal_skin_morphology0.50860805
101MP0010234_abnormal_vibrissa_follicle0.50307313
102MP0003724_increased_susceptibility_to0.49202271
103MP0005166_decreased_susceptibility_to0.47489427
104MP0000627_abnormal_mammary_gland0.46412333
105MP0005666_abnormal_adipose_tissue0.44840316
106MP0004782_abnormal_surfactant_physiolog0.44285816
107MP0002837_dystrophic_cardiac_calcinosis0.43877824
108MP0002166_altered_tumor_susceptibility0.43376412
109MP0001984_abnormal_olfaction0.43204348
110* MP0001784_abnormal_fluid_regulation0.41423696
111MP0005395_other_phenotype0.41396719
112MP0008438_abnormal_cutaneous_collagen0.41168055
113MP0002006_tumorigenesis0.40823679
114MP0005503_abnormal_tendon_morphology0.40553668
115MP0003718_maternal_effect0.40465419
116MP0003953_abnormal_hormone_level0.37693109
117MP0003453_abnormal_keratinocyte_physiol0.37354415
118MP0001243_abnormal_dermal_layer0.37246970
119MP0002136_abnormal_kidney_physiology0.36952586
120MP0003075_altered_response_to0.36885476
121MP0008873_increased_physiological_sensi0.36852462
122MP0002970_abnormal_white_adipose0.36554526
123MP0003638_abnormal_response/metabolism_0.36421685
124MP0002822_catalepsy0.36284664
125MP0008874_decreased_physiological_sensi0.36263413
126MP0005452_abnormal_adipose_tissue0.35250649
127MP0005464_abnormal_platelet_physiology0.35070311
128MP0009672_abnormal_birth_weight0.34386141
129MP0005248_abnormal_Harderian_gland0.34280288
130MP0005423_abnormal_somatic_nervous0.32918558
131MP0003436_decreased_susceptibility_to0.32897261
132MP0000230_abnormal_systemic_arterial0.32295912
133MP0009115_abnormal_fat_cell0.31988768
134MP0003950_abnormal_plasma_membrane0.31731415
135MP0001542_abnormal_bone_strength0.31410933
136MP0004742_abnormal_vestibular_system0.31380710
137MP0001186_pigmentation_phenotype0.30782492
138MP0006082_CNS_inflammation0.30653319
139MP0001881_abnormal_mammary_gland0.30630645
140MP0001853_heart_inflammation0.30492770
141MP0000465_gastrointestinal_hemorrhage0.29939762
142MP0000467_abnormal_esophagus_morphology0.29501903
143MP0001905_abnormal_dopamine_level0.29145246
144MP0002098_abnormal_vibrissa_morphology0.27995078
145MP0005275_abnormal_skin_tensile0.27692357
146MP0003959_abnormal_lean_body0.27668532
147MP0009780_abnormal_chondrocyte_physiolo0.26553286
148MP0004264_abnormal_extraembryonic_tissu0.26286976
149MP0001849_ear_inflammation0.25475990
150MP0003763_abnormal_thymus_physiology0.24540515
151MP0001340_abnormal_eyelid_morphology0.23703958
152MP0002282_abnormal_trachea_morphology0.21368927
153MP0002111_abnormal_tail_morphology0.21259024
154MP0002877_abnormal_melanocyte_morpholog0.20384176
155MP0000358_abnormal_cell_content/0.19442266
156MP0003879_abnormal_hair_cell0.17189513
157MP0009333_abnormal_splenocyte_physiolog0.16896194
158MP0005023_abnormal_wound_healing0.16646685
159MP0002009_preneoplasia0.16596416
160MP0000685_abnormal_immune_system0.15627676
161MP0003699_abnormal_female_reproductive0.15303715
162MP0006138_congestive_heart_failure0.15038021
163MP0005076_abnormal_cell_differentiation0.14368461
164MP0000462_abnormal_digestive_system0.13731562

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.33973351
2Hypotrichosis (HP:0001006)9.15187088
3Woolly hair (HP:0002224)9.04671408
4Onycholysis (HP:0001806)8.89150595
5Intrahepatic cholestasis (HP:0001406)8.02750806
6Conjunctival hamartoma (HP:0100780)7.35595802
7Abnormal hair laboratory examination (HP:0003328)7.14417786
8Deep venous thrombosis (HP:0002625)7.09550152
9Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98741931
10Palmoplantar hyperkeratosis (HP:0000972)6.98730153
11Erythema (HP:0010783)6.92064239
12Abnormality of hair growth rate (HP:0011363)6.77853950
13Slow-growing hair (HP:0002217)6.77853950
14Erythroderma (HP:0001019)6.67675267
15Complement deficiency (HP:0004431)6.64760410
16Palmar hyperkeratosis (HP:0010765)6.61138101
17Prolonged partial thromboplastin time (HP:0003645)6.49558572
18Brittle hair (HP:0002299)6.46068150
19Abnormality of monocarboxylic acid metabolism (HP:0010996)6.43298186
20Xanthomatosis (HP:0000991)6.30609970
21Hypobetalipoproteinemia (HP:0003563)6.18455612
22Plantar hyperkeratosis (HP:0007556)5.71822362
23Congenital ichthyosiform erythroderma (HP:0007431)5.63899981
24Hyperlipoproteinemia (HP:0010980)5.05851408
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.04933569
26Absent eyelashes (HP:0000561)4.99886799
27Abnormality of nail color (HP:0100643)4.94583857
28Epidermoid cyst (HP:0200040)4.87645591
29Abnormality of complement system (HP:0005339)4.87603325
30Hamartoma of the eye (HP:0010568)4.73560286
31Abnormality of the axillary hair (HP:0100134)4.66515357
32Abnormality of secondary sexual hair (HP:0009888)4.66515357
33Hyperglycinemia (HP:0002154)4.62964797
34Hypolipoproteinemia (HP:0010981)4.62376075
35Alopecia of scalp (HP:0002293)4.56889239
36Fat malabsorption (HP:0002630)4.56659049
37Joint hemorrhage (HP:0005261)4.52644947
38Hyperammonemia (HP:0001987)4.48063825
39Abnormality of the common coagulation pathway (HP:0010990)4.31608980
40Dry hair (HP:0011359)4.31232330
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19887550
42Ketosis (HP:0001946)4.14791492
43Abnormality of sulfur amino acid metabolism (HP:0004339)4.06055831
44Nail dystrophy (HP:0008404)4.04923749
45Thick nail (HP:0001805)4.04053368
46Hypoalphalipoproteinemia (HP:0003233)3.96490716
47Sparse eyelashes (HP:0000653)3.93060803
48Abnormality of serine family amino acid metabolism (HP:0010894)3.93017223
49Abnormality of glycine metabolism (HP:0010895)3.93017223
50Abnormality of methionine metabolism (HP:0010901)3.91837118
51Hyperglycinuria (HP:0003108)3.90197217
52Conjugated hyperbilirubinemia (HP:0002908)3.87747788
53Hypoglycemic coma (HP:0001325)3.86192505
54Abnormality of aspartate family amino acid metabolism (HP:0010899)3.85314423
55Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83696912
56Abnormality of the intrinsic pathway (HP:0010989)3.82990680
57Absent hair (HP:0002298)3.64970494
58Abnormal blistering of the skin (HP:0008066)3.57837728
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53290533
60Steatorrhea (HP:0002570)3.50608854
61Abnormality of pyrimidine metabolism (HP:0004353)3.47389015
62Absent eyebrow (HP:0002223)3.42228299
63Abnormality of fatty-acid metabolism (HP:0004359)3.39754880
64Fine hair (HP:0002213)3.32010075
65Hypercholesterolemia (HP:0003124)3.26748901
66Recurrent gram-negative bacterial infections (HP:0005420)3.23250452
67Systemic lupus erythematosus (HP:0002725)3.21606813
68Hypochromic microcytic anemia (HP:0004840)3.21149481
69Hyperbilirubinemia (HP:0002904)3.20698247
70Fragile nails (HP:0001808)3.08143033
71Palmoplantar keratoderma (HP:0000982)3.08124595
72Abnormality of serum amino acid levels (HP:0003112)3.06552569
73Myocardial infarction (HP:0001658)3.05616319
74Follicular hyperkeratosis (HP:0007502)3.01085038
75Skin nodule (HP:0200036)3.00927402
76Hepatocellular carcinoma (HP:0001402)3.00265663
77Ketoacidosis (HP:0001993)2.97541307
78Corneal erosion (HP:0200020)2.95905089
79Delayed CNS myelination (HP:0002188)2.94264960
80Right ventricular cardiomyopathy (HP:0011663)2.92530150
81Abnormality of nucleobase metabolism (HP:0010932)2.86064863
82Hypergammaglobulinemia (HP:0010702)2.84156049
83Spontaneous abortion (HP:0005268)2.77409015
84Acanthosis nigricans (HP:0000956)2.70470875
85Acanthocytosis (HP:0001927)2.69475902
86Metabolic acidosis (HP:0001942)2.63509971
87Neonatal onset (HP:0003623)2.62094214
88Abnormal gallbladder morphology (HP:0012437)2.57239098
89Abnormality of purine metabolism (HP:0004352)2.55402787
90Dicarboxylic aciduria (HP:0003215)2.53802273
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53802273
92Lethargy (HP:0001254)2.51261261
93Spastic diplegia (HP:0001264)2.50502452
94Cholelithiasis (HP:0001081)2.50496007
95Parakeratosis (HP:0001036)2.49611467
96Abnormality of the pupil (HP:0000615)2.48758003
97Hypohidrosis (HP:0000966)2.46958428
98Gout (HP:0001997)2.45457186
99Hypoglycemic seizures (HP:0002173)2.44076632
100Sensorimotor neuropathy (HP:0007141)2.38805330
101Mitral stenosis (HP:0001718)2.33779856
102Abnormal gallbladder physiology (HP:0012438)2.33672791
103Cholecystitis (HP:0001082)2.33672791
104Cerebral edema (HP:0002181)2.33002055
105Ridged nail (HP:0001807)2.32126931
106Blepharitis (HP:0000498)2.31536028
107Milia (HP:0001056)2.30408566
108Gangrene (HP:0100758)2.29439448
109Sparse scalp hair (HP:0002209)2.28100094
110Vascular calcification (HP:0004934)2.23035536
111Irritability (HP:0000737)2.22599911
112Brushfield spots (HP:0001088)2.19256301
113Pancreatitis (HP:0001733)2.15390485
114Malnutrition (HP:0004395)2.14617886
115Hamartoma (HP:0010566)2.13045382
116Congenital, generalized hypertrichosis (HP:0004540)2.12447103
117Abnormality of the gallbladder (HP:0005264)2.12389567
118Amyloidosis (HP:0011034)2.12378936
119Esophageal varix (HP:0002040)2.05201309
120Enlarged kidneys (HP:0000105)2.05002345
121Melanocytic nevus (HP:0000995)2.03744867
122Gingival bleeding (HP:0000225)2.01118318
123Abnormal cartilage morphology (HP:0002763)2.00231091
124Pili torti (HP:0003777)10.5290603
125Vomiting (HP:0002013)1.99062920
126Glomerulonephritis (HP:0000099)1.99057085
127Opisthotonus (HP:0002179)1.98774372
128Hyperinsulinemic hypoglycemia (HP:0000825)1.98749123
129Cardiovascular calcification (HP:0011915)1.97962637
130Hemorrhage of the eye (HP:0011885)1.96739061
131Late onset (HP:0003584)1.96496209
132Renal cortical cysts (HP:0000803)1.96075940
133Rickets (HP:0002748)1.95738152
134Generalized aminoaciduria (HP:0002909)1.95385307
135Abnormal enzyme/coenzyme activity (HP:0012379)1.94426529
136Pruritus (HP:0000989)1.93507641
137Coarse hair (HP:0002208)1.90778616
138Thrombophlebitis (HP:0004418)1.90613439
139Hyperhidrosis (HP:0000975)1.90152151
140Elevated hepatic transaminases (HP:0002910)1.85196920
141Menorrhagia (HP:0000132)1.84845524
142Poikilocytosis (HP:0004447)1.83006011
143Abnormality of iron homeostasis (HP:0011031)1.78980541
144Abnormality of the salivary glands (HP:0010286)1.77975252
145Elevated alkaline phosphatase (HP:0003155)1.76312514
146Abnormality of transition element cation homeostasis (HP:0011030)1.76231965
147Hyperglycemia (HP:0003074)1.76063727
148Oral leukoplakia (HP:0002745)1.74256646
149Advanced eruption of teeth (HP:0006288)1.73145619
150Abnormality of vitamin metabolism (HP:0100508)1.71589315
151Status epilepticus (HP:0002133)1.69598567
152Abnormality of alkaline phosphatase activity (HP:0004379)1.68293032
153Fatigable weakness (HP:0003473)1.67561405
154Abnormality of the neuromuscular junction (HP:0003398)1.67561405
155Abnormal biliary tract physiology (HP:0012439)1.67098294
156Bile duct proliferation (HP:0001408)1.67098294
157Reduced subcutaneous adipose tissue (HP:0003758)1.65630433
158Hydroxyprolinuria (HP:0003080)1.65054330
159Urticaria (HP:0001025)1.60738518
160Abnormality of the dental root (HP:0006486)1.59103496
161Taurodontia (HP:0000679)1.59103496
162Abnormality of permanent molar morphology (HP:0011071)1.59103496
163Skin ulcer (HP:0200042)1.56920632
164Lip pit (HP:0100267)1.56639949
165Natal tooth (HP:0000695)1.55842001
166Abnormality of molar (HP:0011077)1.51504363
167Abnormality of molar morphology (HP:0011070)1.51504363
168Neonatal death (HP:0003811)1.43578054
169Septate vagina (HP:0001153)1.43239568
170Nasolacrimal duct obstruction (HP:0000579)1.38029802
171Abnormality of the dental pulp (HP:0006479)1.37258669
172Eczematoid dermatitis (HP:0000976)1.29310464
173Conical tooth (HP:0000698)1.25566764
174Ventricular tachycardia (HP:0004756)1.20892936
175Oligodontia (HP:0000677)1.19675940
176Dry skin (HP:0000958)1.19350635
177Aplasia involving bones of the upper limbs (HP:0009823)1.19185563
178Aplasia of the phalanges of the hand (HP:0009802)1.19185563
179Aplasia involving bones of the extremities (HP:0009825)1.19185563
180Furrowed tongue (HP:0000221)1.18493918
181Ectropion (HP:0000656)1.18479021
182Breast hypoplasia (HP:0003187)1.13008824
183Abnormality of alanine metabolism (HP:0010916)1.12655854
184Hyperalaninemia (HP:0003348)1.12655854
185Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.12655854
186Papilloma (HP:0012740)1.12060690
187Verrucae (HP:0200043)1.12060690
188Split foot (HP:0001839)1.09960922
189Hypertriglyceridemia (HP:0002155)1.09217906
190Generalized hyperpigmentation (HP:0007440)1.08783109
191Abnormality of the costochondral junction (HP:0000919)1.08415123
192Multifactorial inheritance (HP:0001426)1.08176504
193Ulnar claw (HP:0001178)1.07970534
194Limb dystonia (HP:0002451)1.06487055
195Abnormality of placental membranes (HP:0011409)1.05918672
196Amniotic constriction ring (HP:0009775)1.05918672
197Skin rash (HP:0000988)1.05862613
198Selective tooth agenesis (HP:0001592)1.04894270
199Duplicated collecting system (HP:0000081)1.04704367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.68001085
2ERN14.73643467
3FGFR44.53452853
4EEF2K4.44816040
5MAPKAPK34.42829561
6SIK14.12910080
7ERBB44.03774606
8TAOK33.17272605
9TGFBR13.07408031
10INSRR2.93018050
11STK242.60454918
12MAP3K92.49985732
13MAP2K42.32435693
14MAPK112.28002142
15MST1R2.16695346
16ARAF2.07702212
17EPHB22.07074132
18MYLK2.06218182
19PIK3CG2.06179693
20MAP3K122.04238227
21LATS11.94638606
22KSR21.89866332
23MAPKAPK51.86942860
24RPS6KB21.76253432
25MAP3K21.71132915
26PRPF4B1.70157757
27TRIB31.68312420
28TYK21.64458055
29FGFR21.57040359
30PKN21.55771052
31TRPM71.51150163
32FLT31.50319301
33ABL21.47191441
34NEK91.43857909
35PTK61.43203761
36MAP3K71.42005554
37FRK1.40748321
38NEK61.39322458
39DAPK21.36483755
40ERBB21.32738061
41JAK21.32536920
42EPHA21.32475850
43TESK11.17571996
44MAPK151.16076281
45PRKAA21.15541728
46MAP3K101.15444003
47BRAF1.13822046
48JAK11.09012833
49KDR1.02597350
50PINK10.98579334
51BRD40.98083849
52TBK10.95538164
53MAPK40.95215462
54PDK20.93538927
55PAK40.92024183
56PKN10.91929445
57STK30.91227004
58STK38L0.90187977
59MAP2K30.89730190
60MAP3K140.87686206
61CDK60.86647979
62GRK60.86412183
63CAMK1D0.86369664
64MET0.86355884
65IRAK30.85413120
66CAMK2G0.85089887
67LRRK20.84858844
68PRKCZ0.84731193
69CDK190.82352916
70BUB10.81341739
71TIE10.79968930
72MAPK120.79589598
73EPHB10.79035294
74STK390.77166277
75EPHA30.76602793
76RPS6KB10.75055200
77PRKACG0.74133575
78MOS0.73816484
79PRKAA10.73394938
80MAP3K30.72705786
81FGFR30.72086343
82ILK0.71994971
83KSR10.71484990
84CDK70.65621286
85GSK3A0.65049965
86CDK90.64844173
87MAP2K60.63298192
88DYRK1B0.63229856
89IKBKB0.62051847
90MAPKAPK20.61600702
91RIPK10.59675352
92SGK30.57721258
93CDK120.57313385
94MAP3K110.57294540
95RAF10.56443207
96AURKB0.56308112
97MAPK70.56249682
98NTRK20.56201987
99PDPK10.55190115
100MST40.55025940
101CSNK1G10.54037412
102MAP3K80.53508028
103MARK20.52812536
104CSF1R0.52347128
105CHUK0.50555231
106RPS6KA40.49791516
107PTK20.49746869
108YES10.48404262
109LATS20.48334771
110PDGFRA0.48021993
111PRKCQ0.47831344
112MAP2K10.46670888
113CSK0.44430118
114TTK0.44397397
115ERBB30.43315369
116IGF1R0.43079361
117CAMK1G0.42432310
118MAP3K60.42211140
119TGFBR20.41615329
120IKBKE0.41441634
121ICK0.41145573
122EIF2AK30.41118245
123MINK10.40968415
124EGFR0.40628391
125SGK20.40275484
126MAP3K50.40067843
127SIK20.39566516
128MTOR0.39255204
129PDK30.38510557
130PDK40.38510557
131MAP3K10.37858219
132RET0.37233599
133GRK10.36850233
134MAP3K130.35857656
135DYRK30.35674936
136PRKCG0.35617574
137PRKCH0.35512481
138IRAK10.34936075
139CDK40.34245884
140TYRO30.32880901
141CSNK1G30.31474213
142PRKCI0.31235235
143PAK10.31193858
144CSNK1G20.31187942
145CAMK10.31182826
146MAPK130.31091745
147LMTK20.30425327
148NTRK30.30392026
149PAK30.30355917
150PDK10.30059828
151CSNK1E0.29760268
152PBK0.28477106
153BMX0.27824273
154CAMK40.27608332
155ABL10.27040122
156FER0.27035034
157SGK4940.27010989
158SGK2230.27010989
159CSNK1A1L0.25929405
160PRKCA0.24753411
161FGFR10.23795773

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.07704218
2Nitrogen metabolism_Homo sapiens_hsa009103.42325040
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25268147
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02028706
5Arginine biosynthesis_Homo sapiens_hsa002202.93148150
6Complement and coagulation cascades_Homo sapiens_hsa046102.83883625
7Tryptophan metabolism_Homo sapiens_hsa003802.78800319
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.69931323
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68475133
10Fatty acid degradation_Homo sapiens_hsa000712.60501514
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55680891
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45434556
13Peroxisome_Homo sapiens_hsa041462.24471045
14Butanoate metabolism_Homo sapiens_hsa006502.16253248
15Propanoate metabolism_Homo sapiens_hsa006402.01913085
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98259121
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97216340
18PPAR signaling pathway_Homo sapiens_hsa033201.96393921
19Fatty acid metabolism_Homo sapiens_hsa012121.95610058
20Histidine metabolism_Homo sapiens_hsa003401.87896728
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.84753408
22Chemical carcinogenesis_Homo sapiens_hsa052041.79257262
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77792649
24beta-Alanine metabolism_Homo sapiens_hsa004101.73042070
25Retinol metabolism_Homo sapiens_hsa008301.73010870
26Caffeine metabolism_Homo sapiens_hsa002321.71870756
27Sphingolipid metabolism_Homo sapiens_hsa006001.71607697
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65782824
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64763218
30Staphylococcus aureus infection_Homo sapiens_hsa051501.64094351
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.58787986
32Phenylalanine metabolism_Homo sapiens_hsa003601.55450157
33Phototransduction_Homo sapiens_hsa047441.53136239
34Tyrosine metabolism_Homo sapiens_hsa003501.52104803
35Selenocompound metabolism_Homo sapiens_hsa004501.51756649
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50908824
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47849515
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44970846
39Bile secretion_Homo sapiens_hsa049761.43473741
40Pyruvate metabolism_Homo sapiens_hsa006201.38135755
41Steroid biosynthesis_Homo sapiens_hsa001001.33892853
42Sulfur metabolism_Homo sapiens_hsa009201.33148621
43Vitamin B6 metabolism_Homo sapiens_hsa007501.33019866
44* Fatty acid elongation_Homo sapiens_hsa000621.25964604
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.25697687
46GnRH signaling pathway_Homo sapiens_hsa049121.22307825
47Starch and sucrose metabolism_Homo sapiens_hsa005001.22021137
48Folate biosynthesis_Homo sapiens_hsa007901.20585138
49ABC transporters_Homo sapiens_hsa020101.18376741
50Fat digestion and absorption_Homo sapiens_hsa049751.17698313
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16982249
52Carbon metabolism_Homo sapiens_hsa012001.14386407
53Biosynthesis of amino acids_Homo sapiens_hsa012301.13381019
54Alcoholism_Homo sapiens_hsa050341.04728509
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.03838721
56ECM-receptor interaction_Homo sapiens_hsa045120.99641088
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99009712
58Renin-angiotensin system_Homo sapiens_hsa046140.94960948
59Sulfur relay system_Homo sapiens_hsa041220.94664728
60Serotonergic synapse_Homo sapiens_hsa047260.92060144
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.90713847
62Vitamin digestion and absorption_Homo sapiens_hsa049770.85549946
63Arginine and proline metabolism_Homo sapiens_hsa003300.85367078
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85240410
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83613641
66Lysine degradation_Homo sapiens_hsa003100.79724112
67Prion diseases_Homo sapiens_hsa050200.75510338
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73875068
69Fatty acid biosynthesis_Homo sapiens_hsa000610.73850868
70One carbon pool by folate_Homo sapiens_hsa006700.72661316
71Renin secretion_Homo sapiens_hsa049240.72196602
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.70826007
73Long-term depression_Homo sapiens_hsa047300.70292256
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70141756
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69330201
76Dorso-ventral axis formation_Homo sapiens_hsa043200.69161197
77Glutathione metabolism_Homo sapiens_hsa004800.67364864
78Glycerolipid metabolism_Homo sapiens_hsa005610.64786025
79Thyroid cancer_Homo sapiens_hsa052160.63051111
80VEGF signaling pathway_Homo sapiens_hsa043700.62054413
81Oocyte meiosis_Homo sapiens_hsa041140.58266573
82Pentose phosphate pathway_Homo sapiens_hsa000300.52792670
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51620861
84Circadian rhythm_Homo sapiens_hsa047100.50182782
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50000343
86Lysosome_Homo sapiens_hsa041420.48384941
87Long-term potentiation_Homo sapiens_hsa047200.45982132
88Metabolic pathways_Homo sapiens_hsa011000.45561144
89Olfactory transduction_Homo sapiens_hsa047400.44377402
90Viral carcinogenesis_Homo sapiens_hsa052030.43763612
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42610740
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41852576
93Collecting duct acid secretion_Homo sapiens_hsa049660.41332686
94Glioma_Homo sapiens_hsa052140.40607759
95Protein digestion and absorption_Homo sapiens_hsa049740.39612196
96p53 signaling pathway_Homo sapiens_hsa041150.39216272
97Ras signaling pathway_Homo sapiens_hsa040140.38642195
98Amphetamine addiction_Homo sapiens_hsa050310.37456712
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37278931
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.36975624
101Phagosome_Homo sapiens_hsa041450.33535816
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33424780
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31722682
104Dopaminergic synapse_Homo sapiens_hsa047280.31243906
105Melanogenesis_Homo sapiens_hsa049160.30874524
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30493189
107Pertussis_Homo sapiens_hsa051330.29530645
108Estrogen signaling pathway_Homo sapiens_hsa049150.28245109
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.25425812
110Galactose metabolism_Homo sapiens_hsa000520.24998364
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24711457
112Insulin resistance_Homo sapiens_hsa049310.24450074
113Gastric acid secretion_Homo sapiens_hsa049710.24143797
114Acute myeloid leukemia_Homo sapiens_hsa052210.23276549
115Salivary secretion_Homo sapiens_hsa049700.21710006
116Choline metabolism in cancer_Homo sapiens_hsa052310.21681630
117Linoleic acid metabolism_Homo sapiens_hsa005910.21229911
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.20508418
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.19182890
120Fructose and mannose metabolism_Homo sapiens_hsa000510.17476934
121Malaria_Homo sapiens_hsa051440.16930824
122Synaptic vesicle cycle_Homo sapiens_hsa047210.16841381
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.14601194
124Glucagon signaling pathway_Homo sapiens_hsa049220.12423738
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11618002
126Oxytocin signaling pathway_Homo sapiens_hsa049210.10695244
127Tuberculosis_Homo sapiens_hsa051520.10455533
128AMPK signaling pathway_Homo sapiens_hsa041520.01389756
129Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2424412
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2297363
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2254710
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2209002
133Ether lipid metabolism_Homo sapiens_hsa00565-0.2006448
134Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1987646
135Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1860669
136Bladder cancer_Homo sapiens_hsa05219-0.1731476
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1557853
138African trypanosomiasis_Homo sapiens_hsa05143-0.1547715
139Hepatitis C_Homo sapiens_hsa05160-0.1496942
140Regulation of autophagy_Homo sapiens_hsa04140-0.1426538
141Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1291066
142Amoebiasis_Homo sapiens_hsa05146-0.1180385
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1112143
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0984815
145Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0965210
146Insulin signaling pathway_Homo sapiens_hsa04910-0.0751031
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0522194
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0484573
149Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0456996

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