ELOVL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* fatty acid elongation (GO:0030497)8.50881693
2cholesterol biosynthetic process (GO:0006695)7.45055157
3axon ensheathment in central nervous system (GO:0032291)6.80076693
4central nervous system myelination (GO:0022010)6.80076693
5sterol biosynthetic process (GO:0016126)6.51506816
6* long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.44331067
7* fatty-acyl-CoA biosynthetic process (GO:0046949)6.21396997
8* long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.76499212
9* acyl-CoA biosynthetic process (GO:0071616)5.63067889
10* thioester biosynthetic process (GO:0035384)5.63067889
11* fatty-acyl-CoA metabolic process (GO:0035337)5.57295541
12very long-chain fatty acid metabolic process (GO:0000038)5.24834332
13L-phenylalanine catabolic process (GO:0006559)5.17574213
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.17574213
15acetyl-CoA metabolic process (GO:0006084)4.91025608
16ensheathment of neurons (GO:0007272)4.82442146
17axon ensheathment (GO:0008366)4.82442146
18myelination (GO:0042552)4.77728959
19isoprenoid biosynthetic process (GO:0008299)4.69834455
20L-serine metabolic process (GO:0006563)4.65107335
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64588431
22L-phenylalanine metabolic process (GO:0006558)4.64588431
23DNA double-strand break processing (GO:0000729)4.41887966
24* acyl-CoA metabolic process (GO:0006637)4.39373117
25* thioester metabolic process (GO:0035383)4.39373117
26alpha-linolenic acid metabolic process (GO:0036109)4.31762933
27* triglyceride biosynthetic process (GO:0019432)4.09413060
28response to methylmercury (GO:0051597)3.95767357
29* acylglycerol biosynthetic process (GO:0046463)3.93489422
30* neutral lipid biosynthetic process (GO:0046460)3.93489422
31serine family amino acid biosynthetic process (GO:0009070)3.87954357
32Leydig cell differentiation (GO:0033327)3.82229818
33glycerophospholipid catabolic process (GO:0046475)3.79146750
34aromatic amino acid family catabolic process (GO:0009074)3.77195273
35chromatin remodeling at centromere (GO:0031055)3.77104144
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.71956617
37heme transport (GO:0015886)3.67281366
38cholesterol metabolic process (GO:0008203)3.64844445
39presynaptic membrane assembly (GO:0097105)3.64091485
40steroid biosynthetic process (GO:0006694)3.62689189
41glyoxylate metabolic process (GO:0046487)3.61475563
42ethanol metabolic process (GO:0006067)3.59626901
43biotin metabolic process (GO:0006768)3.59625140
44CENP-A containing nucleosome assembly (GO:0034080)3.57770882
45coenzyme A metabolic process (GO:0015936)3.55669102
46very-low-density lipoprotein particle assembly (GO:0034379)3.46238568
47sterol metabolic process (GO:0016125)3.44652078
48ethanol oxidation (GO:0006069)3.39709629
49histone exchange (GO:0043486)3.36176629
50short-chain fatty acid metabolic process (GO:0046459)3.31735115
51replication fork processing (GO:0031297)3.29759666
52DNA replication-dependent nucleosome assembly (GO:0006335)3.29515520
53DNA replication-dependent nucleosome organization (GO:0034723)3.29515520
54cullin deneddylation (GO:0010388)3.27920767
55bile acid biosynthetic process (GO:0006699)3.26142839
56tyrosine metabolic process (GO:0006570)3.25022305
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22868778
58somatic hypermutation of immunoglobulin genes (GO:0016446)3.22868778
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.22719157
60alcohol biosynthetic process (GO:0046165)3.21024585
61response to phenylpropanoid (GO:0080184)3.20695693
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20549560
63regulation of mitotic spindle checkpoint (GO:1903504)3.20549560
64pantothenate metabolic process (GO:0015939)3.20099229
65* long-chain fatty acid biosynthetic process (GO:0042759)3.19496934
66retinal metabolic process (GO:0042574)3.19223065
67coenzyme catabolic process (GO:0009109)3.17718310
68regulation of centriole replication (GO:0046599)3.17606518
69purine nucleobase biosynthetic process (GO:0009113)3.16953062
70establishment of mitochondrion localization (GO:0051654)3.15288721
71cysteine metabolic process (GO:0006534)3.14214595
72serine family amino acid metabolic process (GO:0009069)3.13278806
73pyrimidine nucleobase catabolic process (GO:0006208)3.12898065
74cellular ketone body metabolic process (GO:0046950)3.12498694
75myelin maintenance (GO:0043217)3.11102233
76apical protein localization (GO:0045176)3.10545439
77negative regulation of neurotransmitter secretion (GO:0046929)3.09726584
78nucleobase biosynthetic process (GO:0046112)3.07365743
79triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06984073
80amyloid precursor protein metabolic process (GO:0042982)3.06579893
81glutathione derivative biosynthetic process (GO:1901687)3.05853540
82glutathione derivative metabolic process (GO:1901685)3.05853540
83DNA damage response, detection of DNA damage (GO:0042769)3.05787213
84coenzyme A biosynthetic process (GO:0015937)3.04229406
85establishment of integrated proviral latency (GO:0075713)3.04208989
86DNA replication checkpoint (GO:0000076)3.02557172
87presynaptic membrane organization (GO:0097090)3.02479409
88protein deneddylation (GO:0000338)3.02416647
89protein-cofactor linkage (GO:0018065)3.02378657
90plasma lipoprotein particle clearance (GO:0034381)3.02133047
91creatine metabolic process (GO:0006600)3.02086469
92response to lipoprotein particle (GO:0055094)3.00598382
93DNA catabolic process, exonucleolytic (GO:0000738)2.97508223
94DNA replication-independent nucleosome organization (GO:0034724)2.96108325
95DNA replication-independent nucleosome assembly (GO:0006336)2.96108325
96regulation of triglyceride catabolic process (GO:0010896)2.95662805
97mitotic metaphase plate congression (GO:0007080)2.95482335
98water-soluble vitamin biosynthetic process (GO:0042364)2.93316319
99pyrimidine-containing compound transmembrane transport (GO:0072531)2.93220880
100regulation of DNA endoreduplication (GO:0032875)2.90967444
101* triglyceride metabolic process (GO:0006641)2.90310935
102iron coordination entity transport (GO:1901678)2.90221878
103IMP biosynthetic process (GO:0006188)2.89974237
104bile acid metabolic process (GO:0008206)2.89941889
105metaphase plate congression (GO:0051310)2.89227036
106aromatic amino acid family metabolic process (GO:0009072)2.89204629
107regulation of collateral sprouting (GO:0048670)2.87702584
108positive regulation of cellular amine metabolic process (GO:0033240)2.87320680
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86828735
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.86764290
111regulation of translation, ncRNA-mediated (GO:0045974)2.86764290
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86764290
113oligodendrocyte differentiation (GO:0048709)2.85791341
114histone H2A acetylation (GO:0043968)2.85103800
115fatty acid catabolic process (GO:0009062)2.82549611
116spindle checkpoint (GO:0031577)2.82278777
117sulfur amino acid catabolic process (GO:0000098)2.81988266
118limb bud formation (GO:0060174)2.81578889
119asymmetric protein localization (GO:0008105)2.80061461
120negative regulation of lipase activity (GO:0060192)2.79267738
121negative regulation of DNA recombination (GO:0045910)2.78876738
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78653310
123fatty acid beta-oxidation (GO:0006635)2.78237551
124proteasome assembly (GO:0043248)2.78082557
125branched-chain amino acid catabolic process (GO:0009083)2.77811630
126mitotic spindle checkpoint (GO:0071174)2.73519755
127ketone body metabolic process (GO:1902224)2.73156208
128primary alcohol catabolic process (GO:0034310)2.71940559
129primary alcohol metabolic process (GO:0034308)2.71919106
130serine family amino acid catabolic process (GO:0009071)2.70527741
131non-recombinational repair (GO:0000726)2.69881069
132double-strand break repair via nonhomologous end joining (GO:0006303)2.69881069
133synapsis (GO:0007129)2.69216498
134glycine metabolic process (GO:0006544)2.69007438
135mitotic sister chromatid cohesion (GO:0007064)2.68554757
136protein K6-linked ubiquitination (GO:0085020)2.67262418
137amyloid precursor protein catabolic process (GO:0042987)2.66709836
138kynurenine metabolic process (GO:0070189)2.66326505
139negative regulation of neurotransmitter transport (GO:0051589)2.66029873
140* acylglycerol metabolic process (GO:0006639)2.65233781
141triglyceride homeostasis (GO:0070328)2.65179418
142acylglycerol homeostasis (GO:0055090)2.65179418
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64566634
144estrogen metabolic process (GO:0008210)2.63812769
145tryptophan metabolic process (GO:0006568)2.63665566
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.62587231
147negative regulation of sister chromatid segregation (GO:0033046)2.62587231
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62587231
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62587231
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62587231
151glycerolipid catabolic process (GO:0046503)2.62577805
152* neutral lipid metabolic process (GO:0006638)2.62515845
153cellular aldehyde metabolic process (GO:0006081)2.62168453
154protein localization to kinetochore (GO:0034501)2.61854116
155cofactor catabolic process (GO:0051187)2.61702372
156respiratory chain complex IV assembly (GO:0008535)2.61457158
157regulation of meiosis I (GO:0060631)2.61232322
158negative regulation of chromosome segregation (GO:0051985)2.60650122
159attachment of spindle microtubules to kinetochore (GO:0008608)2.59555125
160DNA ligation (GO:0006266)2.59505616
161DNA strand renaturation (GO:0000733)2.59121185
162recombinational repair (GO:0000725)2.56679482
163regulation of helicase activity (GO:0051095)2.55682864
164double-strand break repair via homologous recombination (GO:0000724)2.54424424
165telomere maintenance via telomerase (GO:0007004)2.51421683
166regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.51065147
167regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51065147
168resolution of meiotic recombination intermediates (GO:0000712)2.50325308
169nucleobase catabolic process (GO:0046113)2.49372372
170postreplication repair (GO:0006301)2.48686380
171kinetochore organization (GO:0051383)2.47624268
172regulation of mitotic sister chromatid separation (GO:0010965)2.45723242
173regulation of mitotic sister chromatid segregation (GO:0033047)2.45723242
174regulation of sister chromatid segregation (GO:0033045)2.45723242
175regulation of telomere maintenance (GO:0032204)2.43008989
176C4-dicarboxylate transport (GO:0015740)2.42386217
177IMP metabolic process (GO:0046040)2.41912414
178DNA strand elongation involved in DNA replication (GO:0006271)2.41911353
179kinetochore assembly (GO:0051382)2.41311934
180lysine metabolic process (GO:0006553)2.40766006
181lysine catabolic process (GO:0006554)2.40766006
182female gonad development (GO:0008585)2.40409320
183exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38154830
184response to pheromone (GO:0019236)2.37850239
185mitotic spindle assembly checkpoint (GO:0007094)2.37836883
186regulation of chromosome segregation (GO:0051983)2.36401965
187response to X-ray (GO:0010165)2.36252600
188RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36038186
189nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.35679056
190spindle assembly checkpoint (GO:0071173)2.34976872
191telomere maintenance via semi-conservative replication (GO:0032201)2.34418136
192intraciliary transport (GO:0042073)2.32950574
193regulation of centrosome cycle (GO:0046605)2.32664998
194regulation of centrosome duplication (GO:0010824)2.32388463
195isotype switching (GO:0045190)2.31488323
196somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.31488323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.27550998
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.92596877
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15567327
4E2F7_22180533_ChIP-Seq_HELA_Human4.12388102
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.82234261
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.17666804
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.13238792
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96790289
9ZNF274_21170338_ChIP-Seq_K562_Hela2.96442700
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87740772
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85535608
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59925924
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.57924236
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47997836
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.47256397
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.46491036
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46295441
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.32304243
19IGF1R_20145208_ChIP-Seq_DFB_Human2.29983663
20EWS_26573619_Chip-Seq_HEK293_Human2.20652333
21TAF15_26573619_Chip-Seq_HEK293_Human2.16096903
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15522841
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12427237
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08001711
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06974847
26ELK1_19687146_ChIP-ChIP_HELA_Human2.06170402
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98124396
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97774044
29HTT_18923047_ChIP-ChIP_STHdh_Human1.89945238
30P300_19829295_ChIP-Seq_ESCs_Human1.87913326
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80237566
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.79624770
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.78740307
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75678040
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75678040
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75678040
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73164774
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72815473
39* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68424816
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65493331
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58501520
42STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.55393777
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.54482449
44GBX2_23144817_ChIP-Seq_PC3_Human1.53950292
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.51759064
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50475248
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48873606
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48502437
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48221061
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47706721
51* SALL1_21062744_ChIP-ChIP_HESCs_Human1.44134815
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.43598326
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.43337332
54MYC_18940864_ChIP-ChIP_HL60_Human1.42913297
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42889058
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40716904
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38963039
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37244819
59* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37147171
60* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37119724
61* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35676299
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33292337
63VDR_23849224_ChIP-Seq_CD4+_Human1.32912987
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31670735
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30016476
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.29553817
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29484970
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29369754
69IRF1_19129219_ChIP-ChIP_H3396_Human1.28227730
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26972861
71EOMES_21245162_ChIP-Seq_HESCs_Human1.25122864
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25024433
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22002375
74FOXP3_21729870_ChIP-Seq_TREG_Human1.21952070
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.20477846
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20384388
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.19297528
78* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18150027
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18017138
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17168579
81SMAD4_21799915_ChIP-Seq_A2780_Human1.15848731
82FUS_26573619_Chip-Seq_HEK293_Human1.15707343
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14433455
84ER_23166858_ChIP-Seq_MCF-7_Human1.13936453
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12034094
86CLOCK_20551151_ChIP-Seq_293T_Human1.10909375
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10076953
88ZNF263_19887448_ChIP-Seq_K562_Human1.09885856
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08925835
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08073119
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06956629
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.06509024
93CBP_20019798_ChIP-Seq_JUKART_Human1.06493524
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06493524
95* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06420453
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06176382
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.05176277
98SOX9_26525672_Chip-Seq_HEART_Mouse1.04735757
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04368527
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03551519
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03254213
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02835123
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01897617
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.01852344
105NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01650062
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01543629
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01313110
108* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00463134
109VDR_22108803_ChIP-Seq_LS180_Human0.99748990
110* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99745689
111AR_25329375_ChIP-Seq_VCAP_Human0.98617794
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96992958
113TP63_19390658_ChIP-ChIP_HaCaT_Human0.96176300
114NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95968188
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95942216
116* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95810693
117STAT3_23295773_ChIP-Seq_U87_Human0.95358472
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94397037
119* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94296420
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94184235
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94130101
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94005385
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93993260
124BCAT_22108803_ChIP-Seq_LS180_Human0.93974101
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93931968
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93657116
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.93574463
128THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92443956
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92418023
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92418023
131* TCF4_22108803_ChIP-Seq_LS180_Human0.92241979
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92004047
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91450672
134* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89117073
135TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88799807
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88153341
137TP63_17297297_ChIP-ChIP_HaCaT_Human0.88059337
138* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87198963
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.87142077
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.86728547
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.86375987
142* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85659983
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84492858
144* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83869932
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83385475
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82919513
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82107451
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79635107
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78280956
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78256803
151CBP_21632823_ChIP-Seq_H3396_Human0.77415161
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.77268125
153NCOR_22424771_ChIP-Seq_293T_Human0.76726154
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76461060
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75293874
156SOX2_16153702_ChIP-ChIP_HESCs_Human0.73898489
157AR_21909140_ChIP-Seq_LNCAP_Human0.73690059
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.73120073
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.72861515
160* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.72574824
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.72487767
162* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.72271726
163* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71968720
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71740117
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71431414
166SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.71374446
167PHF8_20622853_ChIP-Seq_HELA_Human0.71068149
168* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.70938177
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.70434071
170POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.70047624
171AR_21572438_ChIP-Seq_LNCaP_Human0.69829836
172GATA6_21074721_ChIP-Seq_CACO-2_Human0.69626462
173TBL1_22424771_ChIP-Seq_293T_Human0.68585205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.32825431
2MP0003806_abnormal_nucleotide_metabolis4.25487088
3MP0003011_delayed_dark_adaptation3.85838833
4MP0005360_urolithiasis3.61333316
5MP0005085_abnormal_gallbladder_physiolo3.21890820
6MP0000920_abnormal_myelination3.21522621
7MP0005365_abnormal_bile_salt3.07404409
8MP0008058_abnormal_DNA_repair2.91450623
9MP0002796_impaired_skin_barrier2.87635864
10MP0008877_abnormal_DNA_methylation2.87581702
11MP0010094_abnormal_chromosome_stability2.76115166
12MP0005451_abnormal_body_composition2.75677149
13MP0008875_abnormal_xenobiotic_pharmacok2.52737500
14MP0004381_abnormal_hair_follicle2.50186073
15MP0009840_abnormal_foam_cell2.39391036
16MP0006292_abnormal_olfactory_placode2.36351246
17MP0003693_abnormal_embryo_hatching2.35413180
18MP0003329_amyloid_beta_deposits2.29504157
19MP0004185_abnormal_adipocyte_glucose2.29221910
20MP0001661_extended_life_span2.25614118
21MP0002102_abnormal_ear_morphology2.25214100
22MP0003941_abnormal_skin_development2.15844784
23MP0003690_abnormal_glial_cell2.11410611
24MP0003950_abnormal_plasma_membrane2.04371325
25MP0004957_abnormal_blastocyst_morpholog2.04299452
26MP0000647_abnormal_sebaceous_gland2.01090309
27MP0002736_abnormal_nociception_after1.99075532
28MP0004885_abnormal_endolymph1.95668925
29MP0003111_abnormal_nucleus_morphology1.94674313
30MP0003121_genomic_imprinting1.92825199
31MP0010329_abnormal_lipoprotein_level1.92194596
32MP0008932_abnormal_embryonic_tissue1.92185683
33MP0005332_abnormal_amino_acid1.86650539
34MP0008057_abnormal_DNA_replication1.86171209
35MP0003122_maternal_imprinting1.85126517
36MP0001293_anophthalmia1.84103915
37MP0003136_yellow_coat_color1.83079910
38MP0010678_abnormal_skin_adnexa1.82139870
39MP0006072_abnormal_retinal_apoptosis1.80118408
40MP0003787_abnormal_imprinting1.77750629
41MP0001529_abnormal_vocalization1.74718975
42MP0000462_abnormal_digestive_system1.74269496
43MP0008789_abnormal_olfactory_epithelium1.73966448
44MP0002938_white_spotting1.72974910
45MP0004270_analgesia1.72663004
46MP0002118_abnormal_lipid_homeostasis1.71051987
47MP0000383_abnormal_hair_follicle1.66418113
48MP0001188_hyperpigmentation1.62901360
49MP0001984_abnormal_olfaction1.60685867
50MP0005083_abnormal_biliary_tract1.59595423
51MP0003195_calcinosis1.59088784
52MP0003119_abnormal_digestive_system1.58393297
53MP0002751_abnormal_autonomic_nervous1.55393447
54MP0005501_abnormal_skin_physiology1.53788015
55MP0003632_abnormal_nervous_system1.51163813
56MP0003567_abnormal_fetal_cardiomyocyte1.50160926
57MP0000537_abnormal_urethra_morphology1.49531779
58MP0008007_abnormal_cellular_replicative1.48320493
59MP0005666_abnormal_adipose_tissue1.44251209
60MP0005499_abnormal_olfactory_system1.43587240
61MP0005394_taste/olfaction_phenotype1.43587240
62MP0003718_maternal_effect1.43480444
63MP0002233_abnormal_nose_morphology1.43329579
64MP0003077_abnormal_cell_cycle1.41171919
65MP0000579_abnormal_nail_morphology1.39943099
66MP0004133_heterotaxia1.37748750
67MP0001968_abnormal_touch/_nociception1.37717045
68MP0001666_abnormal_nutrient_absorption1.37218845
69MP0003880_abnormal_central_pattern1.34612299
70MP0000778_abnormal_nervous_system1.34049730
71MP0000516_abnormal_urinary_system1.32111443
72MP0005367_renal/urinary_system_phenotyp1.32111443
73MP0004019_abnormal_vitamin_homeostasis1.31896309
74MP0003634_abnormal_glial_cell1.28535491
75MP0004142_abnormal_muscle_tone1.25538637
76MP0000427_abnormal_hair_cycle1.23712855
77MP0005408_hypopigmentation1.22821376
78MP0002254_reproductive_system_inflammat1.22546017
79MP0004742_abnormal_vestibular_system1.22332555
80MP0000604_amyloidosis1.22093238
81MP0008438_abnormal_cutaneous_collagen1.17917520
82MP0009703_decreased_birth_body1.17625557
83MP0001286_abnormal_eye_development1.16482672
84MP0002234_abnormal_pharynx_morphology1.16257159
85MP0003252_abnormal_bile_duct1.15029514
86MP0006035_abnormal_mitochondrial_morpho1.13444979
87MP0003755_abnormal_palate_morphology1.12679215
88MP0003786_premature_aging1.12199483
89MP0000049_abnormal_middle_ear1.11102935
90MP0001905_abnormal_dopamine_level1.10975718
91MP0001485_abnormal_pinna_reflex1.10526524
92MP0003937_abnormal_limbs/digits/tail_de1.06636207
93MP0010030_abnormal_orbit_morphology1.06598861
94MP0003938_abnormal_ear_development1.06386677
95MP0006276_abnormal_autonomic_nervous1.06296172
96MP0002084_abnormal_developmental_patter1.04892637
97MP0005584_abnormal_enzyme/coenzyme_acti1.04136643
98MP0001486_abnormal_startle_reflex1.03522856
99MP0000631_abnormal_neuroendocrine_gland1.03032524
100MP0002272_abnormal_nervous_system1.02178818
101MP0002229_neurodegeneration1.01893071
102MP0003861_abnormal_nervous_system1.01726852
103MP0000467_abnormal_esophagus_morphology1.00819033
104MP0005171_absent_coat_pigmentation1.00100560
105MP0002184_abnormal_innervation1.00077030
106MP0005409_darkened_coat_color1.00069782
107MP0005275_abnormal_skin_tensile0.99667006
108MP0002697_abnormal_eye_size0.99520583
109MP0002085_abnormal_embryonic_tissue0.97485937
110MP0001929_abnormal_gametogenesis0.96340972
111MP0004197_abnormal_fetal_growth/weight/0.96077970
112MP0003868_abnormal_feces_composition0.96064014
113MP0002111_abnormal_tail_morphology0.95791425
114MP0000762_abnormal_tongue_morphology0.95368833
115MP0000609_abnormal_liver_physiology0.93446151
116MP0005187_abnormal_penis_morphology0.93361757
117MP0000377_abnormal_hair_follicle0.92355499
118MP0009697_abnormal_copulation0.92091897
119MP0002210_abnormal_sex_determination0.91596398
120MP0004215_abnormal_myocardial_fiber0.90938663
121MP0002282_abnormal_trachea_morphology0.88673601
122MP0005551_abnormal_eye_electrophysiolog0.88350096
123MP0010771_integument_phenotype0.87784452
124MP0005084_abnormal_gallbladder_morpholo0.87740971
125MP0000747_muscle_weakness0.87566089
126MP0000566_synostosis0.86754531
127MP0001299_abnormal_eye_distance/0.86490246
128MP0000653_abnormal_sex_gland0.86028305
129MP0001697_abnormal_embryo_size0.84604052
130MP0005391_vision/eye_phenotype0.83137637
131MP0001145_abnormal_male_reproductive0.82662352
132MP0008872_abnormal_physiological_respon0.82562843
133MP0002098_abnormal_vibrissa_morphology0.82372092
134MP0004147_increased_porphyrin_level0.82212046
135MP0005375_adipose_tissue_phenotype0.80918186
136MP0003698_abnormal_male_reproductive0.79481565
137MP0002971_abnormal_brown_adipose0.79164126
138MP0009745_abnormal_behavioral_response0.77976096
139MP0000372_irregular_coat_pigmentation0.77809645
140MP0003385_abnormal_body_wall0.77687524
141MP0001730_embryonic_growth_arrest0.77031288
142MP0005380_embryogenesis_phenotype0.75817098
143MP0001672_abnormal_embryogenesis/_devel0.75817098
144MP0003123_paternal_imprinting0.75302219
145MP0004134_abnormal_chest_morphology0.73209364
146MP0001340_abnormal_eyelid_morphology0.73128915
147MP0009672_abnormal_birth_weight0.73041815
148MP0005195_abnormal_posterior_eye0.72808067
149MP0002064_seizures0.71229603
150MP0005395_other_phenotype0.70811660
151MP0005253_abnormal_eye_physiology0.70108031
152MP0001346_abnormal_lacrimal_gland0.69538413
153MP0000955_abnormal_spinal_cord0.69536402
154MP0001177_atelectasis0.69340099
155MP0005670_abnormal_white_adipose0.69095721
156MP0008260_abnormal_autophagy0.67436684
157MP0005075_abnormal_melanosome_morpholog0.65330695
158MP0001727_abnormal_embryo_implantation0.64771212
159MP0001216_abnormal_epidermal_layer0.64646182
160MP0003631_nervous_system_phenotype0.62797691
161MP0003890_abnormal_embryonic-extraembry0.62659305
162MP0002066_abnormal_motor_capabilities/c0.61515947
163MP0002090_abnormal_vision0.60869821
164MP0006036_abnormal_mitochondrial_physio0.60255756
165MP0002752_abnormal_somatic_nervous0.60227538
166MP0001440_abnormal_grooming_behavior0.60202886
167MP0002734_abnormal_mechanical_nocicepti0.59494984
168MP0009046_muscle_twitch0.58169367
169MP0002882_abnormal_neuron_morphology0.58126928
170MP0005386_behavior/neurological_phenoty0.57280637
171MP0004924_abnormal_behavior0.57280637
172MP0004130_abnormal_muscle_cell0.56906594

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.05697819
2Increased serum pyruvate (HP:0003542)5.04264002
3Abnormality of glycolysis (HP:0004366)5.04264002
4Abnormality of the labia minora (HP:0012880)4.70887211
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.65591970
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.65591970
7Intrahepatic cholestasis (HP:0001406)4.30336153
8Neurofibrillary tangles (HP:0002185)4.07456805
9Abnormality of the corticospinal tract (HP:0002492)3.95717006
10Congenital ichthyosiform erythroderma (HP:0007431)3.81555814
11Hypobetalipoproteinemia (HP:0003563)3.76916452
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69095896
13Abnormality of glycine metabolism (HP:0010895)3.66949675
14Abnormality of serine family amino acid metabolism (HP:0010894)3.66949675
15Sensory axonal neuropathy (HP:0003390)3.64835207
16Insidious onset (HP:0003587)3.59724622
17Termporal pattern (HP:0011008)3.59724622
18Hyperglycinemia (HP:0002154)3.59002392
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.47278919
20Xanthomatosis (HP:0000991)3.45315535
21Hyperlipoproteinemia (HP:0010980)3.44321749
22Deep venous thrombosis (HP:0002625)3.36398299
23Colon cancer (HP:0003003)3.31132531
24Cerebral inclusion bodies (HP:0100314)3.21667039
25Partial agenesis of the corpus callosum (HP:0001338)3.07662626
26Cerebral hypomyelination (HP:0006808)3.02707055
27Spastic paraparesis (HP:0002313)3.01531748
28Hyperglycinuria (HP:0003108)2.98289182
29Abnormal lung lobation (HP:0002101)2.94485394
30Volvulus (HP:0002580)2.81838736
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78764233
32Epidermoid cyst (HP:0200040)2.77706861
33Ependymoma (HP:0002888)2.76930501
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75393934
35Meckel diverticulum (HP:0002245)2.75170366
36Ileus (HP:0002595)2.75101020
37Hypolipoproteinemia (HP:0010981)2.70952367
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70688784
39Peripheral hypomyelination (HP:0007182)2.68578447
40Conjugated hyperbilirubinemia (HP:0002908)2.66235488
41Abnormality of the ileum (HP:0001549)2.65713801
42Anomalous pulmonary venous return (HP:0010772)2.64974987
43Intention tremor (HP:0002080)2.61868780
44Hyperammonemia (HP:0001987)2.61167743
45Abnormality of methionine metabolism (HP:0010901)2.55399770
46Chromsome breakage (HP:0040012)2.53582222
47Spastic gait (HP:0002064)2.52815571
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52100675
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.51884744
50Cortical dysplasia (HP:0002539)2.50635179
51Brushfield spots (HP:0001088)2.47299483
52Leukodystrophy (HP:0002415)2.46082172
53Methylmalonic acidemia (HP:0002912)2.45912409
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45028689
55Pancreatic cysts (HP:0001737)2.43228361
56Prolonged partial thromboplastin time (HP:0003645)2.42264525
57Relative macrocephaly (HP:0004482)2.41863014
58Pancreatic fibrosis (HP:0100732)2.40923531
59Abnormality of chromosome stability (HP:0003220)2.39876305
60True hermaphroditism (HP:0010459)2.33245669
61Abnormality of serum amino acid levels (HP:0003112)2.32506261
62Intestinal atresia (HP:0011100)2.29325009
63Nephronophthisis (HP:0000090)2.29066890
64Cerebral edema (HP:0002181)2.27499296
65Ectopic kidney (HP:0000086)2.27467974
66Glioma (HP:0009733)2.26058823
67Astrocytoma (HP:0009592)2.25921163
68Abnormality of the astrocytes (HP:0100707)2.25921163
69Molar tooth sign on MRI (HP:0002419)2.25641730
70Abnormality of midbrain morphology (HP:0002418)2.25641730
71Abnormality of fatty-acid metabolism (HP:0004359)2.24326169
72Birth length less than 3rd percentile (HP:0003561)2.23795897
73Abnormality of the pulmonary veins (HP:0011718)2.23751316
74Hypokalemic alkalosis (HP:0001949)2.22596160
75Bifid tongue (HP:0010297)2.21566044
76Adrenal hypoplasia (HP:0000835)2.21099697
77Onion bulb formation (HP:0003383)2.20599048
78Morphological abnormality of the pyramidal tract (HP:0002062)2.19477272
79Erythroderma (HP:0001019)2.18165573
80Pendular nystagmus (HP:0012043)2.17880944
81Ketosis (HP:0001946)2.16702494
82Hypoplastic pelvis (HP:0008839)2.16661914
83CNS hypomyelination (HP:0003429)2.15454838
84Fat malabsorption (HP:0002630)2.12547996
85Coronal craniosynostosis (HP:0004440)2.11988836
86Small intestinal stenosis (HP:0012848)2.11895662
87Duodenal stenosis (HP:0100867)2.11895662
88Hypoalphalipoproteinemia (HP:0003233)2.11617425
89Clitoromegaly (HP:0000057)2.10790104
90Large earlobe (HP:0009748)2.09574541
91Abnormality of the duodenum (HP:0002246)2.08407920
92Sloping forehead (HP:0000340)2.07468896
93Alacrima (HP:0000522)2.06831923
94Abnormality of the preputium (HP:0100587)2.06238602
95Lissencephaly (HP:0001339)2.04362225
96Lethargy (HP:0001254)2.03794269
97Genital tract atresia (HP:0001827)2.03439282
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.01126101
99Renal hypoplasia (HP:0000089)1.99421623
100Cupped ear (HP:0000378)1.99331630
101Turricephaly (HP:0000262)1.98935676
102Progressive inability to walk (HP:0002505)1.98669166
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.97668118
104Supernumerary spleens (HP:0009799)1.96145166
105Septo-optic dysplasia (HP:0100842)1.95918827
106Vaginal atresia (HP:0000148)1.95577001
107Delayed myelination (HP:0012448)1.94373015
108Akinesia (HP:0002304)1.94354636
109Short tibia (HP:0005736)1.94256781
110Dandy-Walker malformation (HP:0001305)1.93329162
111Dicarboxylic aciduria (HP:0003215)1.93277828
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93277828
113Autoamputation (HP:0001218)1.92477568
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.92186002
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.90984228
116Hypophosphatemic rickets (HP:0004912)1.90849997
117Medial flaring of the eyebrow (HP:0010747)1.90673734
118Patellar aplasia (HP:0006443)1.90249930
119Abnormality of vitamin metabolism (HP:0100508)1.88583934
120Retinal dysplasia (HP:0007973)1.88053032
121Anteriorly placed anus (HP:0001545)1.86180448
122Methylmalonic aciduria (HP:0012120)1.85516936
123Small hand (HP:0200055)1.85420083
124Renal Fanconi syndrome (HP:0001994)1.85324503
125Lipid accumulation in hepatocytes (HP:0006561)1.85045966
126Neoplasm of the adrenal cortex (HP:0100641)1.84779645
127Hypoplastic female external genitalia (HP:0012815)1.84429892
128Paraparesis (HP:0002385)1.83222779
129Sclerocornea (HP:0000647)1.83028294
130Scrotal hypoplasia (HP:0000046)1.82561082
131Labial hypoplasia (HP:0000066)1.82216474
132Horseshoe kidney (HP:0000085)1.82070252
133Hypoglycemic coma (HP:0001325)1.81956817
134Preaxial hand polydactyly (HP:0001177)1.81524276
135Aplasia/Hypoplasia of the patella (HP:0006498)1.81095947
136Gastrointestinal atresia (HP:0002589)1.80556727
137Nephrogenic diabetes insipidus (HP:0009806)1.78113303
138Cerebral hemorrhage (HP:0001342)1.77700662
139Abnormality of the renal medulla (HP:0100957)1.77478710
140Steatorrhea (HP:0002570)1.77315145
141Postaxial foot polydactyly (HP:0001830)1.76983396
142Acute encephalopathy (HP:0006846)1.75598556
143Stenosis of the external auditory canal (HP:0000402)1.74884881
144Irritability (HP:0000737)1.73752668
145Nephroblastoma (Wilms tumor) (HP:0002667)1.73426602
146Postaxial hand polydactyly (HP:0001162)1.72812291
147Amniotic constriction ring (HP:0009775)1.72590546
148Abnormality of placental membranes (HP:0011409)1.72590546
149Acute necrotizing encephalopathy (HP:0006965)1.72533000
150Dysmetria (HP:0001310)1.72177985
151Abnormality of the labia (HP:0000058)1.72064166
152Rhabdomyosarcoma (HP:0002859)1.71984770
153Drooling (HP:0002307)1.71962825
154Embryonal renal neoplasm (HP:0011794)1.71576402
155Congenital primary aphakia (HP:0007707)1.71340213
156Gait imbalance (HP:0002141)1.71279911
157Abnormal hair whorl (HP:0010721)1.71007896
158Abnormal auditory evoked potentials (HP:0006958)1.70562490
159Stridor (HP:0010307)1.70532027
160Pancreatic islet-cell hyperplasia (HP:0004510)1.70178756
161Absent radius (HP:0003974)1.69917988
162Epiphyseal stippling (HP:0010655)1.69888252
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69848053
164Medulloblastoma (HP:0002885)1.69723788
165Spastic tetraparesis (HP:0001285)1.69283261
1663-Methylglutaconic aciduria (HP:0003535)1.68133280
167Increased hepatocellular lipid droplets (HP:0006565)1.68056675
168Abnormality of the clitoris (HP:0000056)1.67565009
169Rickets (HP:0002748)1.65521941
170Segmental peripheral demyelination/remyelination (HP:0003481)1.65136636
171Absent forearm bone (HP:0003953)1.65079219
172Aplasia involving forearm bones (HP:0009822)1.65079219
173Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64509344
174Chronic hepatic failure (HP:0100626)1.64449017
175Neoplasm of the adrenal gland (HP:0100631)1.64086009
176Anencephaly (HP:0002323)1.63924508
177Inability to walk (HP:0002540)1.63673954
178Broad-based gait (HP:0002136)1.62980073
179Clonus (HP:0002169)1.62548514
180Delayed CNS myelination (HP:0002188)1.62334340
181Esophageal atresia (HP:0002032)1.61715874
182Triphalangeal thumb (HP:0001199)1.61496636
183Increased nuchal translucency (HP:0010880)1.60928643
184Narrow forehead (HP:0000341)1.59602718
185Optic nerve hypoplasia (HP:0000609)1.59424088
186Progressive macrocephaly (HP:0004481)1.56215353
187Neoplasm of the oral cavity (HP:0100649)1.55940038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.82636648
2OXSR14.14825198
3TRIM283.33435947
4BCR3.28696576
5EPHB12.85621214
6FGFR22.83605273
7MET2.82793143
8MKNK22.77270520
9PNCK2.46587542
10BCKDK2.42982218
11PBK2.42190721
12FRK2.38218459
13PLK42.33050702
14ICK2.30112863
15NUAK12.16738935
16CSNK1G32.11944064
17CDC71.95215161
18WNK41.92067303
19ERBB41.90596001
20PKN11.88314790
21CSNK1A1L1.86797821
22ZAK1.84723717
23CDK191.84553849
24EIF2AK31.84399404
25CSNK1G11.82602800
26BMPR1B1.78068996
27NEK11.77890979
28TNIK1.76043241
29EIF2AK11.71378899
30MARK11.65648494
31LIMK11.63100628
32CSNK1G21.56329479
33DYRK21.56204865
34EPHA21.55799041
35MAP4K21.55115818
36BUB11.51561764
37PLK21.51307714
38BRSK21.49941905
39CAMK1D1.48576957
40ERBB31.48461394
41VRK21.46671190
42UHMK11.40566393
43EPHA41.40164951
44MAP3K41.37730806
45PLK11.34422916
46WNK11.33473451
47ACVR1B1.31515803
48MAPK131.30445503
49NTRK11.29150362
50CAMK1G1.27022736
51TAF11.14553254
52TYRO31.14320426
53ROCK21.10456159
54FGR1.09574413
55PAK61.04919003
56MINK11.04558159
57VRK11.04551293
58CAMK2B1.04101073
59TESK21.00673300
60ATR0.97549682
61NEK60.96767658
62STK38L0.96233896
63DYRK30.95463446
64CDK140.92366373
65MAPKAPK50.92212753
66MST40.92148842
67EIF2AK20.91441186
68AKT30.90170207
69MKNK10.89769558
70GRK10.89621057
71TTK0.86486378
72STK160.86084028
73PAK30.85169150
74ATM0.79918672
75CDK150.79668974
76CAMK2G0.79494765
77CAMK2D0.79098009
78BRSK10.78438686
79SGK4940.78279355
80SGK2230.78279355
81NTRK30.77003720
82GSK3A0.76829967
83RPS6KA40.75788158
84CSNK1D0.74861438
85PDK40.73844993
86PDK30.73844993
87SIK30.73759569
88CDK180.72173325
89YES10.71056860
90CSNK1E0.70940251
91CDK11A0.70353210
92KSR10.68181901
93CASK0.65670708
94MAP2K70.65478508
95CDK30.65142123
96SIK10.63228454
97INSRR0.62652510
98PRPF4B0.58848491
99TGFBR10.57928177
100AURKA0.56191688
101CHEK10.54333620
102PINK10.54203449
103ADRBK20.54110867
104CDK50.53639156
105AURKB0.52071823
106PDPK10.52035619
107CCNB10.51272349
108DDR20.50498992
109IRAK20.50005601
110BRD40.49351021
111FGFR10.48965787
112LATS10.48800210
113ABL20.47521403
114TLK10.46469521
115NME10.45814501
116STK30.45515298
117CSNK1A10.44399412
118NEK20.44235181
119WEE10.43448253
120PRKDC0.42574037
121CAMK2A0.42569992
122MST1R0.42402950
123MAP3K20.41556423
124CHEK20.41479969
125PDK20.41215833
126MAP2K40.40842449
127MARK20.39877075
128PAK10.38813825
129FER0.38086044
130TSSK60.37447482
131RPS6KA50.37113780
132PRKD10.35735571
133LATS20.35570125
134PRKCQ0.34343835
135CSNK2A10.33512059
136EPHB20.33428388
137MAP3K120.33125567
138PRKACB0.31984948
139PRKACA0.31440733
140CSNK2A20.31174274
141CDK10.30314850
142MAPK100.29969900
143NLK0.29742754
144CDK20.29725986
145STK110.29379657
146PRKCG0.28500058
147WNK30.26973306
148ALK0.26784063
149PRKCE0.26669288
150DAPK10.26513452
151PRKAA20.26314585
152PRKG10.25982836
153PRKD30.25679247
154CLK10.25207836
155SRPK10.24724966
156ROCK10.24714840
157RAF10.24433109
158PLK30.24312444

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.83945375
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.42219987
3* Fatty acid elongation_Homo sapiens_hsa000623.65756467
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.54924809
5* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.18331384
6Non-homologous end-joining_Homo sapiens_hsa034502.92280123
7Butanoate metabolism_Homo sapiens_hsa006502.63878937
8Propanoate metabolism_Homo sapiens_hsa006402.58984457
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49575937
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43417227
11Mismatch repair_Homo sapiens_hsa034302.42958764
12* Fatty acid metabolism_Homo sapiens_hsa012122.33532872
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30081936
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.21045878
15DNA replication_Homo sapiens_hsa030302.18163286
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12414007
17Fanconi anemia pathway_Homo sapiens_hsa034602.09254121
18Vitamin B6 metabolism_Homo sapiens_hsa007502.09104156
19Homologous recombination_Homo sapiens_hsa034402.03860445
20Nitrogen metabolism_Homo sapiens_hsa009102.03591741
21Fatty acid degradation_Homo sapiens_hsa000712.01775465
22Fatty acid biosynthesis_Homo sapiens_hsa000611.96716412
23Histidine metabolism_Homo sapiens_hsa003401.94734308
24Peroxisome_Homo sapiens_hsa041461.90219520
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83946043
26Retinol metabolism_Homo sapiens_hsa008301.76963451
27RNA transport_Homo sapiens_hsa030131.74500234
28Base excision repair_Homo sapiens_hsa034101.66394664
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65211857
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.62243353
31Pyruvate metabolism_Homo sapiens_hsa006201.61868581
32Sulfur metabolism_Homo sapiens_hsa009201.60711868
33PPAR signaling pathway_Homo sapiens_hsa033201.60669713
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55955144
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54105557
36Tryptophan metabolism_Homo sapiens_hsa003801.53503660
37RNA degradation_Homo sapiens_hsa030181.51774340
38Chemical carcinogenesis_Homo sapiens_hsa052041.50789182
39beta-Alanine metabolism_Homo sapiens_hsa004101.48066870
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46715672
41Cell cycle_Homo sapiens_hsa041101.45574010
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37167999
43Arginine biosynthesis_Homo sapiens_hsa002201.35144608
44Spliceosome_Homo sapiens_hsa030401.29310735
45Nucleotide excision repair_Homo sapiens_hsa034201.28308524
46Ether lipid metabolism_Homo sapiens_hsa005651.25955749
47Glutathione metabolism_Homo sapiens_hsa004801.21362469
48Nicotine addiction_Homo sapiens_hsa050331.20158199
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18293756
50Tyrosine metabolism_Homo sapiens_hsa003501.17896789
51Fat digestion and absorption_Homo sapiens_hsa049751.16825504
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15615224
53Arginine and proline metabolism_Homo sapiens_hsa003301.12660455
54Folate biosynthesis_Homo sapiens_hsa007901.12257584
55Carbon metabolism_Homo sapiens_hsa012001.10359707
56Phenylalanine metabolism_Homo sapiens_hsa003601.09610003
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08059760
58Phototransduction_Homo sapiens_hsa047441.05399996
59Vitamin digestion and absorption_Homo sapiens_hsa049771.00325478
60Sphingolipid metabolism_Homo sapiens_hsa006001.00023681
61Oocyte meiosis_Homo sapiens_hsa041140.99836622
62Pyrimidine metabolism_Homo sapiens_hsa002400.99155054
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.96029051
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95928903
65Purine metabolism_Homo sapiens_hsa002300.95347124
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93946327
67Biosynthesis of amino acids_Homo sapiens_hsa012300.93504822
68Linoleic acid metabolism_Homo sapiens_hsa005910.92463895
69mRNA surveillance pathway_Homo sapiens_hsa030150.86085010
70Oxidative phosphorylation_Homo sapiens_hsa001900.85920280
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.85768767
72Proteasome_Homo sapiens_hsa030500.85462970
73Glycerolipid metabolism_Homo sapiens_hsa005610.83298633
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82542265
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.82215596
76Complement and coagulation cascades_Homo sapiens_hsa046100.80746462
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80459475
78Metabolic pathways_Homo sapiens_hsa011000.71445112
79Bile secretion_Homo sapiens_hsa049760.71008805
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.67711451
81p53 signaling pathway_Homo sapiens_hsa041150.66853955
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58028217
83Pentose phosphate pathway_Homo sapiens_hsa000300.58020066
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57839570
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57689258
86Taste transduction_Homo sapiens_hsa047420.54479382
87Parkinsons disease_Homo sapiens_hsa050120.53239638
88Sulfur relay system_Homo sapiens_hsa041220.52380154
89Wnt signaling pathway_Homo sapiens_hsa043100.50413759
90TGF-beta signaling pathway_Homo sapiens_hsa043500.49293835
91Selenocompound metabolism_Homo sapiens_hsa004500.48989440
92ABC transporters_Homo sapiens_hsa020100.48753793
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48647319
94Axon guidance_Homo sapiens_hsa043600.48416740
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46325463
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43354024
97Alzheimers disease_Homo sapiens_hsa050100.43199188
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41755868
99RNA polymerase_Homo sapiens_hsa030200.38573919
100Starch and sucrose metabolism_Homo sapiens_hsa005000.36590774
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36577083
102Tight junction_Homo sapiens_hsa045300.34950943
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34139774
104Caffeine metabolism_Homo sapiens_hsa002320.34076298
105Protein export_Homo sapiens_hsa030600.33492022
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33222872
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32536339
108Lysine degradation_Homo sapiens_hsa003100.30358736
109N-Glycan biosynthesis_Homo sapiens_hsa005100.28479202
110Arachidonic acid metabolism_Homo sapiens_hsa005900.24609095
111Huntingtons disease_Homo sapiens_hsa050160.24588228
112Ovarian steroidogenesis_Homo sapiens_hsa049130.23061052
113One carbon pool by folate_Homo sapiens_hsa006700.22902501
114Renal cell carcinoma_Homo sapiens_hsa052110.13411851
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12228437
116AMPK signaling pathway_Homo sapiens_hsa041520.10965153
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10188710
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.10008007
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.06847983
120Regulation of autophagy_Homo sapiens_hsa041400.05933163
121Staphylococcus aureus infection_Homo sapiens_hsa051500.05080076
122Long-term depression_Homo sapiens_hsa047300.04257990
123Mineral absorption_Homo sapiens_hsa049780.04200117
124Hedgehog signaling pathway_Homo sapiens_hsa043400.03866695
125Basal transcription factors_Homo sapiens_hsa030220.00922864
126Hippo signaling pathway_Homo sapiens_hsa04390-0.0656072
127Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0654356
128Basal cell carcinoma_Homo sapiens_hsa05217-0.0305079
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0223785
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0195451
131Serotonergic synapse_Homo sapiens_hsa04726-0.0069229

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