ELP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)4.70880659
2DNA unwinding involved in DNA replication (GO:0006268)4.65437536
3pre-miRNA processing (GO:0031054)4.55246815
4Golgi transport vesicle coating (GO:0048200)4.40792262
5COPI coating of Golgi vesicle (GO:0048205)4.40792262
6histone arginine methylation (GO:0034969)4.29554298
7chaperone-mediated protein transport (GO:0072321)4.11266454
8peptidyl-arginine methylation (GO:0018216)4.08152509
9peptidyl-arginine N-methylation (GO:0035246)4.08152509
10protein-cofactor linkage (GO:0018065)3.72493328
11mitochondrial RNA metabolic process (GO:0000959)3.66469338
12double-strand break repair via nonhomologous end joining (GO:0006303)3.65006060
13non-recombinational repair (GO:0000726)3.65006060
14nucleobase biosynthetic process (GO:0046112)3.58316777
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54057646
16folic acid-containing compound biosynthetic process (GO:0009396)3.52741996
17IMP biosynthetic process (GO:0006188)3.51887791
18regulation of helicase activity (GO:0051095)3.42464705
19establishment of viral latency (GO:0019043)3.39374156
20spliceosomal tri-snRNP complex assembly (GO:0000244)3.35619005
21formation of translation preinitiation complex (GO:0001731)3.33164228
22DNA deamination (GO:0045006)3.29512720
23chromatin remodeling at centromere (GO:0031055)3.19432356
24CENP-A containing nucleosome assembly (GO:0034080)3.19081907
25aspartate family amino acid biosynthetic process (GO:0009067)3.15020156
26spindle checkpoint (GO:0031577)3.12717390
27L-serine metabolic process (GO:0006563)3.12402794
28regulation of translational termination (GO:0006449)3.10861546
29succinate metabolic process (GO:0006105)3.09517097
30purine nucleobase biosynthetic process (GO:0009113)3.06431815
31DNA strand elongation (GO:0022616)3.02684430
32metaphase plate congression (GO:0051310)3.02570801
33DNA ligation (GO:0006266)3.01409791
34histone H2A monoubiquitination (GO:0035518)3.00114671
35IMP metabolic process (GO:0046040)2.98683128
36DNA replication-dependent nucleosome assembly (GO:0006335)2.96978639
37DNA replication-dependent nucleosome organization (GO:0034723)2.96978639
38protein localization to kinetochore (GO:0034501)2.95994787
39amino acid salvage (GO:0043102)2.95980349
40L-methionine salvage (GO:0071267)2.95980349
41L-methionine biosynthetic process (GO:0071265)2.95980349
42pore complex assembly (GO:0046931)2.94969473
43attachment of spindle microtubules to kinetochore (GO:0008608)2.94187407
44mitotic nuclear envelope disassembly (GO:0007077)2.93697373
45regulation of translational fidelity (GO:0006450)2.93502063
46regulation of gene silencing by RNA (GO:0060966)2.92538376
47regulation of posttranscriptional gene silencing (GO:0060147)2.92538376
48regulation of gene silencing by miRNA (GO:0060964)2.92538376
49DNA double-strand break processing (GO:0000729)2.92196787
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91560915
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89571001
52pyrimidine nucleobase catabolic process (GO:0006208)2.89303981
53tRNA metabolic process (GO:0006399)2.89112505
54nuclear envelope disassembly (GO:0051081)2.88541904
55membrane disassembly (GO:0030397)2.88541904
56positive regulation of mitochondrial fission (GO:0090141)2.87991078
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87121881
58DNA replication initiation (GO:0006270)2.85883336
59negative regulation of histone methylation (GO:0031061)2.84037979
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83353142
61negative regulation of microtubule polymerization (GO:0031115)2.81985014
62DNA strand elongation involved in DNA replication (GO:0006271)2.81962670
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78771039
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78771039
65negative regulation of DNA recombination (GO:0045910)2.78653174
66regulation of mitotic sister chromatid separation (GO:0010965)2.77979019
67regulation of mitotic sister chromatid segregation (GO:0033047)2.77979019
68regulation of sister chromatid segregation (GO:0033045)2.77979019
69ribosome assembly (GO:0042255)2.77879787
70methionine biosynthetic process (GO:0009086)2.77512143
71peroxisome fission (GO:0016559)2.77074107
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75733586
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75718406
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75718406
75nuclear pore organization (GO:0006999)2.75089687
76DNA geometric change (GO:0032392)2.74067230
77coenzyme A biosynthetic process (GO:0015937)2.73288525
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73136598
79sulfur amino acid biosynthetic process (GO:0000097)2.71546403
80ribonucleoprotein complex disassembly (GO:0032988)2.71288411
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70463587
82peptidyl-lysine dimethylation (GO:0018027)2.70100164
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69101615
84DNA duplex unwinding (GO:0032508)2.69030442
85maturation of 5.8S rRNA (GO:0000460)2.68166788
86histone H4-K12 acetylation (GO:0043983)2.67710394
87DNA catabolic process, exonucleolytic (GO:0000738)2.67298245
88regulation of chromosome segregation (GO:0051983)2.67188792
89mitotic sister chromatid cohesion (GO:0007064)2.66788859
90establishment of mitochondrion localization (GO:0051654)2.66661419
91protein maturation by protein folding (GO:0022417)2.66651700
92ubiquinone metabolic process (GO:0006743)2.61690237
937-methylguanosine mRNA capping (GO:0006370)2.61101854
94telomere maintenance via telomerase (GO:0007004)2.60088938
95termination of RNA polymerase I transcription (GO:0006363)2.59883912
96negative regulation of ligase activity (GO:0051352)2.59859813
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59859813
98positive regulation of synapse maturation (GO:0090129)2.59400705
99cullin deneddylation (GO:0010388)2.58148114
100methionine metabolic process (GO:0006555)2.57847415
101maturation of SSU-rRNA (GO:0030490)2.57485230
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.56815715
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56815715
104ribosome biogenesis (GO:0042254)2.55082084
105tRNA aminoacylation for protein translation (GO:0006418)2.53977980
106regulation of DNA damage checkpoint (GO:2000001)2.51765431
107negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49565560
108regulation of telomere maintenance via telomerase (GO:0032210)2.45042968
109telomere maintenance via telomere lengthening (GO:0010833)2.43488620
110nuclear pore complex assembly (GO:0051292)2.43233897
111tRNA aminoacylation (GO:0043039)2.42961086
112amino acid activation (GO:0043038)2.42961086
113cerebellar Purkinje cell layer development (GO:0021680)2.41020819
114protein complex localization (GO:0031503)2.40525966
115peptidyl-arginine modification (GO:0018195)2.40442589
116establishment of integrated proviral latency (GO:0075713)2.39759168
117sister chromatid segregation (GO:0000819)2.39688572
118regulation of short-term neuronal synaptic plasticity (GO:0048172)2.39460474
119histone H2A ubiquitination (GO:0033522)2.38754444
120chaperone-mediated protein complex assembly (GO:0051131)2.38305996
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.38195962
122establishment of monopolar cell polarity (GO:0061162)2.38195962
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.37251233
124mitotic spindle assembly checkpoint (GO:0007094)2.37126113
125regulation of sister chromatid cohesion (GO:0007063)2.37001354
126spliceosomal snRNP assembly (GO:0000387)2.36570373
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36536615
128spliceosomal complex assembly (GO:0000245)2.36444137
129positive regulation of nuclease activity (GO:0032075)2.35960727
130negative regulation of chromosome segregation (GO:0051985)2.34028486
131de novo protein folding (GO:0006458)2.32708122
132pteridine-containing compound biosynthetic process (GO:0042559)2.32353352
133paraxial mesoderm development (GO:0048339)2.32177815
134mitotic sister chromatid segregation (GO:0000070)2.31868635
135spindle assembly checkpoint (GO:0071173)2.30844815
136heterochromatin organization (GO:0070828)2.30819626
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.30524819
138negative regulation of sister chromatid segregation (GO:0033046)2.30524819
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.30524819
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.30524819
141viral mRNA export from host cell nucleus (GO:0046784)2.30386640
142mitotic metaphase plate congression (GO:0007080)2.28725871
143protein deneddylation (GO:0000338)2.28689413
144positive regulation of chromosome segregation (GO:0051984)2.25877286
145establishment of apical/basal cell polarity (GO:0035089)2.25776300
146intra-S DNA damage checkpoint (GO:0031573)2.25721904
147histone H2A acetylation (GO:0043968)2.24702495
148regulation of translational initiation (GO:0006446)2.23007147
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.22830784
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.22639089
151histone H4-K5 acetylation (GO:0043981)2.22079139
152histone H4-K8 acetylation (GO:0043982)2.22079139
153mitotic spindle checkpoint (GO:0071174)2.21963702
154DNA strand renaturation (GO:0000733)2.20548380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32371314
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.99049278
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53381973
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07052538
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77051958
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.76638434
7ELK1_19687146_ChIP-ChIP_HELA_Human2.75391490
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65387963
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58038235
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53823014
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47260022
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.44666038
13* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44491973
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43511941
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37520151
16IGF1R_20145208_ChIP-Seq_DFB_Human2.31758735
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26090671
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25936640
19ESR1_15608294_ChIP-ChIP_MCF-7_Human2.19932466
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19269583
21ZNF274_21170338_ChIP-Seq_K562_Hela2.14675528
22* XRN2_22483619_ChIP-Seq_HELA_Human2.14521292
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12759720
24CIITA_25753668_ChIP-Seq_RAJI_Human2.07603406
25* EST1_17652178_ChIP-ChIP_JURKAT_Human2.06105158
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.05153540
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02413661
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02335732
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99571872
30MYC_22102868_ChIP-Seq_BL_Human1.96060874
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.95618378
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.93685753
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90914753
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86758361
35* GABP_17652178_ChIP-ChIP_JURKAT_Human1.84864580
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80958617
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80828804
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78477392
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77594266
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74997577
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74824898
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74662939
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74400888
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73564080
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72508745
46GABP_19822575_ChIP-Seq_HepG2_Human1.71787548
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70205141
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69759580
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69119393
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67887787
51TTF2_22483619_ChIP-Seq_HELA_Human1.65183504
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64962777
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63229567
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57416472
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.57370837
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57020018
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56262116
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55350944
59IRF1_19129219_ChIP-ChIP_H3396_Human1.53764104
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53389751
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.51642308
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51078144
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48974680
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.48718406
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48104869
66* VDR_23849224_ChIP-Seq_CD4+_Human1.47707207
67EZH2_22144423_ChIP-Seq_EOC_Human1.46930562
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46920229
69KDM5A_27292631_Chip-Seq_BREAST_Human1.42902683
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40700593
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.40302644
72FOXP3_21729870_ChIP-Seq_TREG_Human1.38007906
73AR_21909140_ChIP-Seq_LNCAP_Human1.37765907
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37569022
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.37133034
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36700526
77* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35396216
78DCP1A_22483619_ChIP-Seq_HELA_Human1.34730190
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34580433
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33931827
81EWS_26573619_Chip-Seq_HEK293_Human1.33611306
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29962994
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29924065
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29864318
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27713780
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27521385
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24842715
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24136747
89FUS_26573619_Chip-Seq_HEK293_Human1.22630309
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20967550
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20018586
92MYC_18940864_ChIP-ChIP_HL60_Human1.19914857
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19124773
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18386778
95* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17848013
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17520524
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15880493
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13467635
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.12706711
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12394024
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12205462
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.11989427
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11066248
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09697527
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09147230
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08809254
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08392083
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07207805
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06330113
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05622944
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05320802
112TFEB_21752829_ChIP-Seq_HELA_Human1.05277767
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04943499
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03382519
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03103011
116ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02088847
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01256027
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00876062
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00157354
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99897122
121RARB_27405468_Chip-Seq_BRAIN_Mouse0.98776365
122CHD1_26751641_Chip-Seq_LNCaP_Human0.98029618
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97659279
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97197413
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97130838
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.96985154
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96856790
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.94995543
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93948042
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.89737767
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.89453228
132TAF15_26573619_Chip-Seq_HEK293_Human0.88360442
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87114687
134* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83675386
135GBX2_23144817_ChIP-Seq_PC3_Human0.83585534
136TP53_22573176_ChIP-Seq_HFKS_Human0.83328035
137* SALL4_22934838_ChIP-ChIP_CD34+_Human0.81797826
138SOX9_26525672_Chip-Seq_HEART_Mouse0.79269533
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78873596
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77240661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.14296513
2MP0003283_abnormal_digestive_organ3.05018416
3MP0010094_abnormal_chromosome_stability2.92297713
4MP0004957_abnormal_blastocyst_morpholog2.74729743
5MP0003111_abnormal_nucleus_morphology2.73998905
6MP0009780_abnormal_chondrocyte_physiolo2.47525597
7MP0003693_abnormal_embryo_hatching2.43722575
8MP0004859_abnormal_synaptic_plasticity2.34265798
9MP0002638_abnormal_pupillary_reflex2.28059584
10MP0003077_abnormal_cell_cycle2.11294619
11MP0010352_gastrointestinal_tract_polyps2.09249015
12MP0003122_maternal_imprinting2.07928075
13MP0000013_abnormal_adipose_tissue2.07651017
14MP0001730_embryonic_growth_arrest2.05580657
15MP0003121_genomic_imprinting2.01608246
16MP0003718_maternal_effect1.99410719
17MP0002102_abnormal_ear_morphology1.98232898
18MP0002877_abnormal_melanocyte_morpholog1.96217049
19MP0001529_abnormal_vocalization1.96206176
20MP0003786_premature_aging1.95340928
21MP0003119_abnormal_digestive_system1.94835577
22MP0002909_abnormal_adrenal_gland1.92119068
23MP0000537_abnormal_urethra_morphology1.90439189
24MP0008260_abnormal_autophagy1.89795298
25MP0008789_abnormal_olfactory_epithelium1.86450600
26MP0003890_abnormal_embryonic-extraembry1.81267705
27MP0001984_abnormal_olfaction1.80253141
28MP0002084_abnormal_developmental_patter1.75370597
29MP0006276_abnormal_autonomic_nervous1.74640174
30MP0008057_abnormal_DNA_replication1.74435391
31MP0004133_heterotaxia1.71893822
32MP0000569_abnormal_digit_pigmentation1.70425667
33MP0006292_abnormal_olfactory_placode1.69389001
34MP0004233_abnormal_muscle_weight1.68473008
35MP0005394_taste/olfaction_phenotype1.67763484
36MP0005499_abnormal_olfactory_system1.67763484
37MP0004270_analgesia1.67315985
38MP0008932_abnormal_embryonic_tissue1.58941806
39MP0005187_abnormal_penis_morphology1.58280096
40MP0001697_abnormal_embryo_size1.56433134
41MP0002085_abnormal_embryonic_tissue1.56224025
42MP0005253_abnormal_eye_physiology1.55586966
43MP0003635_abnormal_synaptic_transmissio1.55493321
44MP0008058_abnormal_DNA_repair1.54476942
45MP0001986_abnormal_taste_sensitivity1.52738788
46MP0000350_abnormal_cell_proliferation1.52534745
47MP0008877_abnormal_DNA_methylation1.52417305
48MP0006072_abnormal_retinal_apoptosis1.50778598
49MP0009697_abnormal_copulation1.47364938
50MP0000678_abnormal_parathyroid_gland1.47275813
51MP0001672_abnormal_embryogenesis/_devel1.41655745
52MP0005380_embryogenesis_phenotype1.41655745
53MP0001661_extended_life_span1.40505307
54MP0005646_abnormal_pituitary_gland1.40460609
55MP0002653_abnormal_ependyma_morphology1.39546234
56MP0003567_abnormal_fetal_cardiomyocyte1.39411405
57MP0004145_abnormal_muscle_electrophysio1.39318290
58MP0002080_prenatal_lethality1.38999962
59MP0001293_anophthalmia1.38400432
60MP0002837_dystrophic_cardiac_calcinosis1.37279932
61MP0004858_abnormal_nervous_system1.35062906
62MP0008995_early_reproductive_senescence1.33819311
63MP0003646_muscle_fatigue1.33580609
64MP0004197_abnormal_fetal_growth/weight/1.29405942
65MP0004811_abnormal_neuron_physiology1.27747830
66MP0002063_abnormal_learning/memory/cond1.27439049
67MP0003861_abnormal_nervous_system1.27309885
68MP0003656_abnormal_erythrocyte_physiolo1.25695459
69MP0002234_abnormal_pharynx_morphology1.25016681
70MP0000428_abnormal_craniofacial_morphol1.23876351
71MP0000358_abnormal_cell_content/1.23098210
72MP0008007_abnormal_cellular_replicative1.21684563
73MP0003984_embryonic_growth_retardation1.21269264
74MP0010030_abnormal_orbit_morphology1.20331854
75MP0003385_abnormal_body_wall1.19681607
76MP0002088_abnormal_embryonic_growth/wei1.19021785
77MP0009672_abnormal_birth_weight1.18914400
78MP0000955_abnormal_spinal_cord1.17903419
79MP0001944_abnormal_pancreas_morphology1.17702889
80MP0002233_abnormal_nose_morphology1.17593709
81MP0003705_abnormal_hypodermis_morpholog1.15942663
82MP0003186_abnormal_redox_activity1.13816985
83MP0002086_abnormal_extraembryonic_tissu1.12404502
84MP0006036_abnormal_mitochondrial_physio1.12117679
85MP0000372_irregular_coat_pigmentation1.11554756
86MP0001764_abnormal_homeostasis1.07913034
87MP0003942_abnormal_urinary_system1.06524077
88MP0005423_abnormal_somatic_nervous1.05798564
89MP0000778_abnormal_nervous_system1.05471740
90MP0002751_abnormal_autonomic_nervous1.04844979
91MP0000534_abnormal_ureter_morphology1.04020748
92MP0001346_abnormal_lacrimal_gland1.02036429
93MP0004264_abnormal_extraembryonic_tissu1.01655713
94MP0004084_abnormal_cardiac_muscle1.01025487
95MP0002152_abnormal_brain_morphology1.00562384
96MP0003329_amyloid_beta_deposits1.00495451
97MP0002269_muscular_atrophy0.99052014
98MP0002184_abnormal_innervation0.98404379
99MP0002734_abnormal_mechanical_nocicepti0.96869683
100MP0001929_abnormal_gametogenesis0.96282686
101MP0006035_abnormal_mitochondrial_morpho0.96141659
102MP0003115_abnormal_respiratory_system0.94490850
103MP0003787_abnormal_imprinting0.92831002
104MP0000003_abnormal_adipose_tissue0.92422363
105MP0005391_vision/eye_phenotype0.91471427
106MP0000631_abnormal_neuroendocrine_gland0.91153733
107MP0005645_abnormal_hypothalamus_physiol0.90823405
108MP0000749_muscle_degeneration0.90362382
109MP0000647_abnormal_sebaceous_gland0.90272306
110MP0003935_abnormal_craniofacial_develop0.89478570
111MP0005623_abnormal_meninges_morphology0.89270509
112MP0005408_hypopigmentation0.88911365
113MP0000747_muscle_weakness0.88421274
114MP0010307_abnormal_tumor_latency0.87774104
115MP0001849_ear_inflammation0.87758898
116MP0000465_gastrointestinal_hemorrhage0.87421185
117MP0003221_abnormal_cardiomyocyte_apopto0.86329863
118MP0002095_abnormal_skin_pigmentation0.84991950
119MP0009703_decreased_birth_body0.84927596
120MP0004215_abnormal_myocardial_fiber0.84885159
121MP0002572_abnormal_emotion/affect_behav0.84864880
122MP0002114_abnormal_axial_skeleton0.84076073
123MP0002733_abnormal_thermal_nociception0.84052687
124MP0002210_abnormal_sex_determination0.80040749
125MP0002693_abnormal_pancreas_physiology0.80002285
126MP0002160_abnormal_reproductive_system0.78543628
127MP0010386_abnormal_urinary_bladder0.78301048
128MP0005076_abnormal_cell_differentiation0.78240114
129MP0002081_perinatal_lethality0.78213611
130MP0002177_abnormal_outer_ear0.78210317
131MP0002822_catalepsy0.77016572
132MP0000751_myopathy0.76781796
133MP0008770_decreased_survivor_rate0.76152372
134MP0000049_abnormal_middle_ear0.75859752
135MP0002882_abnormal_neuron_morphology0.75563045
136MP0005367_renal/urinary_system_phenotyp0.75006521
137MP0000516_abnormal_urinary_system0.75006521
138MP0006054_spinal_hemorrhage0.74748835
139MP0008961_abnormal_basal_metabolism0.74525348
140MP0003880_abnormal_central_pattern0.73501386
141MP0003937_abnormal_limbs/digits/tail_de0.73409288
142MP0003315_abnormal_perineum_morphology0.73191924
143MP0000759_abnormal_skeletal_muscle0.72696950
144MP0001348_abnormal_lacrimal_gland0.72275132
145MP0003698_abnormal_male_reproductive0.71753118
146MP0000750_abnormal_muscle_regeneration0.71526190
147MP0002111_abnormal_tail_morphology0.69605942
148MP0000313_abnormal_cell_death0.68898698
149MP0001299_abnormal_eye_distance/0.68698203
150MP0000653_abnormal_sex_gland0.68191015
151MP0001145_abnormal_male_reproductive0.68030965
152MP0002064_seizures0.67447264
153MP0003699_abnormal_female_reproductive0.66366294

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.04613767
2Visual hallucinations (HP:0002367)4.02987788
3Cortical dysplasia (HP:0002539)3.99956002
4Ependymoma (HP:0002888)3.88686365
5Increased serum pyruvate (HP:0003542)3.84727360
6Colon cancer (HP:0003003)3.18396934
7Astrocytoma (HP:0009592)3.18263073
8Abnormality of the astrocytes (HP:0100707)3.18263073
9Fibular aplasia (HP:0002990)3.07135951
10Abnormality of the lower motor neuron (HP:0002366)3.03470479
11Microvesicular hepatic steatosis (HP:0001414)2.95540068
12Cholecystitis (HP:0001082)2.95248224
13Abnormal gallbladder physiology (HP:0012438)2.95248224
14Nephrogenic diabetes insipidus (HP:0009806)2.85636527
15Hyperacusis (HP:0010780)2.80157305
16Exercise-induced muscle cramps (HP:0003710)2.73153204
17Tubulointerstitial nephritis (HP:0001970)2.71764882
18Congenital primary aphakia (HP:0007707)2.71712178
19Shoulder girdle muscle weakness (HP:0003547)2.71264046
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.66798120
21Medulloblastoma (HP:0002885)2.65103168
22Amyotrophic lateral sclerosis (HP:0007354)2.65001452
23Termporal pattern (HP:0011008)2.62305240
24Insidious onset (HP:0003587)2.62305240
25Medial flaring of the eyebrow (HP:0010747)2.59941586
26Renal duplication (HP:0000075)2.57107465
27Long clavicles (HP:0000890)2.56814336
28Atrophy/Degeneration involving motor neurons (HP:0007373)2.54091613
29Glioma (HP:0009733)2.50664597
30Abnormality of the labia minora (HP:0012880)2.45797437
31Neoplasm of the peripheral nervous system (HP:0100007)2.43310244
32Hyperglycinemia (HP:0002154)2.41678187
33Missing ribs (HP:0000921)2.41276366
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37942458
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37942458
36Cholelithiasis (HP:0001081)2.32284651
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29812716
38Abnormal protein N-linked glycosylation (HP:0012347)2.29812716
39Abnormal protein glycosylation (HP:0012346)2.29812716
40Abnormal glycosylation (HP:0012345)2.29812716
41Retinal dysplasia (HP:0007973)2.23718373
42Insomnia (HP:0100785)2.22819262
43Resting tremor (HP:0002322)2.22533448
44Bowel diverticulosis (HP:0005222)2.22439885
45Increased hepatocellular lipid droplets (HP:0006565)2.21940990
46Orthostatic hypotension (HP:0001278)2.21466124
47Hypoplasia of the pons (HP:0012110)2.20330977
48Genital tract atresia (HP:0001827)2.19845733
49Pheochromocytoma (HP:0002666)2.19751239
50Abnormality of the metopic suture (HP:0005556)2.18374636
51Degeneration of anterior horn cells (HP:0002398)2.17926783
52Abnormality of the anterior horn cell (HP:0006802)2.17926783
53Hypsarrhythmia (HP:0002521)2.17480860
54Abnormal lung lobation (HP:0002101)2.17374276
55Renovascular hypertension (HP:0100817)2.16744671
56Papillary thyroid carcinoma (HP:0002895)2.16589997
57Broad foot (HP:0001769)2.16542854
58Lipid accumulation in hepatocytes (HP:0006561)2.14182111
59Chromsome breakage (HP:0040012)2.13579690
60Vaginal atresia (HP:0000148)2.13094746
61Abnormal pancreas size (HP:0012094)2.12687778
62EEG with generalized epileptiform discharges (HP:0011198)2.11225917
63Abnormal gallbladder morphology (HP:0012437)2.10859729
64Neoplasm of the oral cavity (HP:0100649)2.10556288
65Neoplasm of the adrenal gland (HP:0100631)2.10474432
66Cerebral hypomyelination (HP:0006808)2.10413183
67Increased serum lactate (HP:0002151)2.07985767
68Pelvic girdle muscle weakness (HP:0003749)2.07071686
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07062643
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06388012
71Adenoma sebaceum (HP:0009720)2.06091911
72Angiofibromas (HP:0010615)2.06091911
73Premature ovarian failure (HP:0008209)2.05334738
74Hyperalaninemia (HP:0003348)2.04690566
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04690566
76Abnormality of alanine metabolism (HP:0010916)2.04690566
77Epileptiform EEG discharges (HP:0011182)2.02518290
78Papilledema (HP:0001085)2.02061165
79Neuroendocrine neoplasm (HP:0100634)1.98956337
80Annular pancreas (HP:0001734)1.98836944
81Abnormality of methionine metabolism (HP:0010901)1.98770668
82Thyroid-stimulating hormone excess (HP:0002925)1.98526322
83Freckling (HP:0001480)1.98140548
84Multiple enchondromatosis (HP:0005701)1.96721766
85Poor coordination (HP:0002370)1.96143515
86Intellectual disability, profound (HP:0002187)1.95758289
87Short tibia (HP:0005736)1.94054184
88Abnormality of serum amino acid levels (HP:0003112)1.93904469
89Abnormality of pain sensation (HP:0010832)1.92726632
90Impaired pain sensation (HP:0007328)1.92726632
91Facial hemangioma (HP:0000329)1.92640040
92Hypoplastic pelvis (HP:0008839)1.91931077
93Neoplasm of the pancreas (HP:0002894)1.89587028
94Methylmalonic acidemia (HP:0002912)1.89402876
95Lissencephaly (HP:0001339)1.87045436
96Intestinal polyposis (HP:0200008)1.86191468
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85801472
98Increased nuchal translucency (HP:0010880)1.85331055
99Postnatal microcephaly (HP:0005484)1.85094946
100Agnosia (HP:0010524)1.83185273
101Rough bone trabeculation (HP:0100670)1.82583799
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.82454433
103Aplastic anemia (HP:0001915)1.82385673
104Abnormality of the hip-girdle musculature (HP:0001445)1.82198289
105Abnormality of the musculature of the pelvis (HP:0001469)1.82198289
106Rhabdomyosarcoma (HP:0002859)1.82093011
107Intestinal polyp (HP:0005266)1.82043767
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81528809
109Renal cortical cysts (HP:0000803)1.79756333
110Abnormality of the pancreatic islet cells (HP:0006476)1.79747812
111Abnormality of endocrine pancreas physiology (HP:0012093)1.79747812
112Overriding aorta (HP:0002623)1.78658098
113Spinal muscular atrophy (HP:0007269)1.77677781
114Abnormality of the pons (HP:0007361)1.77618687
115Elfin facies (HP:0004428)1.77223069
116Selective tooth agenesis (HP:0001592)1.77212767
117Meckel diverticulum (HP:0002245)1.76634833
118Birth length less than 3rd percentile (HP:0003561)1.76499260
119Abnormality of the ileum (HP:0001549)1.76398821
120Stenosis of the external auditory canal (HP:0000402)1.76375692
121Nephroblastoma (Wilms tumor) (HP:0002667)1.76293038
122Split foot (HP:0001839)1.76264601
123Increased CSF lactate (HP:0002490)1.75970260
124CNS demyelination (HP:0007305)1.75084603
125Pointed chin (HP:0000307)1.75067179
126Impaired proprioception (HP:0010831)1.74025066
127Facial cleft (HP:0002006)1.73413621
128Carpal bone hypoplasia (HP:0001498)1.73238848
129Methylmalonic aciduria (HP:0012120)1.72326794
130Adducted thumb (HP:0001181)1.72100425
131Abnormality of glycine metabolism (HP:0010895)1.71125561
132Abnormality of serine family amino acid metabolism (HP:0010894)1.71125561
133Acute encephalopathy (HP:0006846)1.70941397
134Oligodactyly (hands) (HP:0001180)1.69768366
135Increased intramyocellular lipid droplets (HP:0012240)1.69635001
136Supernumerary spleens (HP:0009799)1.68998036
137Delusions (HP:0000746)1.68008371
138Aplasia/hypoplasia of the uterus (HP:0008684)1.67919013
139Lactic acidosis (HP:0003128)1.67746305
140Sloping forehead (HP:0000340)1.67687056
141Sacral dimple (HP:0000960)1.66240801
142Pancreatic islet-cell hyperplasia (HP:0004510)1.65874024
143Impaired vibration sensation in the lower limbs (HP:0002166)1.64286844
144Rimmed vacuoles (HP:0003805)1.63975039
145Megalocornea (HP:0000485)1.62640326
146Neuroblastic tumors (HP:0004376)1.61231114
147Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.61231114
148Neuroblastoma (HP:0003006)1.61231114
149Primitive neuroectodermal tumor (HP:0030065)1.61231114
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.60705614
151Depression (HP:0000716)1.60552343
152Abnormality of the calcaneus (HP:0008364)1.60361543
153Central scotoma (HP:0000603)1.60334055
154Patellar aplasia (HP:0006443)1.60244339
155Basal cell carcinoma (HP:0002671)1.59326468
156Premature graying of hair (HP:0002216)1.59325840
157Neoplasm of striated muscle (HP:0009728)1.58271576
158Unsteady gait (HP:0002317)1.57774192
159Emotional lability (HP:0000712)1.57243634
160Urinary urgency (HP:0000012)1.56715573
161Cellular immunodeficiency (HP:0005374)1.55421122
162CNS hypomyelination (HP:0003429)1.52830849
163Menstrual irregularities (HP:0000858)1.52158753
164Athetosis (HP:0002305)1.51688776
165Broad palm (HP:0001169)1.51114040
166High anterior hairline (HP:0009890)1.50778206
167Impaired smooth pursuit (HP:0007772)1.50757315
168Hepatoblastoma (HP:0002884)1.50610144
169Aplasia/Hypoplasia of the patella (HP:0006498)1.50576933
170Hyperinsulinemic hypoglycemia (HP:0000825)1.50272922
171Malignant neoplasm of the central nervous system (HP:0100836)1.50028951
172Cortical visual impairment (HP:0100704)1.49863761
173Gait imbalance (HP:0002141)1.48934507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK23.99803192
2PASK3.68644253
3MAP4K23.47929196
4TSSK63.00469170
5MARK12.96149030
6NEK12.80413324
7BCR2.73489870
8ZAK2.58322586
9SCYL22.53655699
10BUB12.39061440
11CDC72.37667011
12PKN22.33486198
13NUAK12.26651660
14WEE12.24524105
15PNCK2.24364996
16NTRK32.21461753
17EEF2K2.21315981
18EIF2AK12.00729812
19MAP2K71.85838635
20MINK11.83385973
21LATS21.83165009
22BCKDK1.76475430
23PLK31.71184436
24PRKD31.70048927
25FLT31.67339793
26PBK1.62059561
27PINK11.61913906
28WNK31.61048854
29TTK1.59078058
30PLK41.55481015
31MAP3K41.54701614
32CCNB11.52587665
33TRIB31.51451373
34STK161.49659939
35MKNK11.49503387
36RPS6KA41.49280698
37CSNK1G31.49105755
38CSNK1A1L1.48174020
39MAP3K91.48048702
40TRIM281.47896019
41BRSK11.44752159
42OBSCN1.36522915
43CSNK1G11.33129557
44CHEK21.32286667
45RPS6KB21.31570281
46ALK1.31561819
47PLK11.27241393
48EIF2AK31.26936103
49KSR11.23432759
50CSNK1G21.21659206
51DYRK31.20204353
52FRK1.19361021
53DAPK11.15881701
54RAF11.15518339
55PIK3CA1.14271211
56NEK21.13624312
57PHKG11.13108253
58PHKG21.13108253
59UHMK11.09595463
60TAF11.06583712
61TGFBR11.06440937
62NEK61.03811768
63PDGFRA1.02089757
64FGFR11.01871687
65KSR20.99251962
66AURKA0.97025233
67NTRK10.96381612
68PRKCI0.92550772
69MAP3K100.91409761
70DYRK20.91153324
71CAMKK10.88829998
72CSNK1E0.87694331
73ATR0.87334997
74BRSK20.86134290
75CDK40.85850215
76CDK20.85111818
77PDK30.84795899
78PDK40.84795899
79CHEK10.82837605
80PTK60.82372314
81EPHA20.79095721
82MAP2K40.78490900
83PLK20.77195268
84MAP3K50.77074794
85MTOR0.76766061
86CDK140.76226090
87CDK150.74712359
88CLK10.74592993
89RPS6KA50.73997507
90VRK10.73917801
91PAK60.72957537
92EPHA40.72506828
93VRK20.72166104
94HIPK20.72016508
95ERBB40.71858325
96CDK180.71625920
97AKT20.69863981
98CAMK1D0.68815368
99CDK11A0.68674947
100TLK10.67478780
101RET0.66097954
102CDK10.66048859
103CDK120.64560333
104MAP2K60.64305450
105PAK40.62710925
106CSNK2A20.61965404
107PAK30.61017895
108MAP3K60.60569861
109TESK10.60475681
110MAP3K20.60021289
111MKNK20.59982316
112BRD40.59971217
113RPS6KB10.59678922
114CDK70.59271180
115SRPK10.58716099
116MST40.58607803
117NTRK20.57661891
118LIMK10.57418066
119MAPK130.55317010
120AURKB0.54683551
121ATM0.54646868
122PRKDC0.54252916
123STK390.53908909
124ERBB30.53387058
125RPS6KA20.52855489
126OXSR10.52811106
127CDK50.52145626
128TESK20.50226650
129PRKCG0.50123490
130MAP3K80.49449796
131MAPK90.48674886
132CSNK2A10.48654260
133MAPK100.48059496
134FER0.44188782
135CSNK1D0.43230662
136CAMKK20.42719065
137PRKACB0.42142064
138GSK3B0.41944905
139MAP3K120.40742510
140CASK0.40006418
141LMTK20.39911876
142CDK190.39648365
143STK38L0.38467317
144FGR0.38168446
145CAMK1G0.37076025
146CSNK1A10.36676568
147EIF2AK20.35592967
148PKN10.35146803

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.27966620
2DNA replication_Homo sapiens_hsa030302.88440733
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78438817
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.65548441
5RNA transport_Homo sapiens_hsa030132.58095069
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45739323
7Spliceosome_Homo sapiens_hsa030402.36290936
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27151631
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10466953
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10190681
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07215060
12Propanoate metabolism_Homo sapiens_hsa006401.98829307
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89473354
14Oocyte meiosis_Homo sapiens_hsa041141.89143617
15Cell cycle_Homo sapiens_hsa041101.87553652
16Butanoate metabolism_Homo sapiens_hsa006501.86569087
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.84825145
18mRNA surveillance pathway_Homo sapiens_hsa030151.84464857
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82796018
20Nucleotide excision repair_Homo sapiens_hsa034201.82657777
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79169512
22Base excision repair_Homo sapiens_hsa034101.63158172
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59307122
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.59227823
25Synaptic vesicle cycle_Homo sapiens_hsa047211.58347199
26Fatty acid elongation_Homo sapiens_hsa000621.57468034
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55902713
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55730449
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.53997920
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53728085
31One carbon pool by folate_Homo sapiens_hsa006701.48488464
32Insulin secretion_Homo sapiens_hsa049111.47866963
33Amphetamine addiction_Homo sapiens_hsa050311.45852295
34Long-term potentiation_Homo sapiens_hsa047201.45077874
35N-Glycan biosynthesis_Homo sapiens_hsa005101.44127154
36RNA polymerase_Homo sapiens_hsa030201.43938213
37Proteasome_Homo sapiens_hsa030501.43175445
38Steroid biosynthesis_Homo sapiens_hsa001001.42422885
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42218182
40Ribosome_Homo sapiens_hsa030101.36043323
41Dopaminergic synapse_Homo sapiens_hsa047281.32223234
42Pyruvate metabolism_Homo sapiens_hsa006201.29960321
43mTOR signaling pathway_Homo sapiens_hsa041501.28379560
44Fatty acid metabolism_Homo sapiens_hsa012121.25004609
45Pentose phosphate pathway_Homo sapiens_hsa000301.20732874
46Alcoholism_Homo sapiens_hsa050341.18942517
47Colorectal cancer_Homo sapiens_hsa052101.18886075
48Biosynthesis of amino acids_Homo sapiens_hsa012301.18351432
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18205626
50Protein export_Homo sapiens_hsa030601.16621623
51RNA degradation_Homo sapiens_hsa030181.16339206
52Circadian entrainment_Homo sapiens_hsa047131.12178483
53Homologous recombination_Homo sapiens_hsa034401.10882252
54Glucagon signaling pathway_Homo sapiens_hsa049221.10117859
55Gap junction_Homo sapiens_hsa045401.08675725
56Pyrimidine metabolism_Homo sapiens_hsa002401.01027249
57Vibrio cholerae infection_Homo sapiens_hsa051100.99714869
58Hippo signaling pathway_Homo sapiens_hsa043900.97861172
59Caffeine metabolism_Homo sapiens_hsa002320.97849344
60Estrogen signaling pathway_Homo sapiens_hsa049150.97703895
61Cocaine addiction_Homo sapiens_hsa050300.96112232
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.94909708
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94380413
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94063436
65Peroxisome_Homo sapiens_hsa041460.91365226
66GABAergic synapse_Homo sapiens_hsa047270.90924210
67Nicotine addiction_Homo sapiens_hsa050330.88300275
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87142117
69Olfactory transduction_Homo sapiens_hsa047400.85178405
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82844804
71Thyroid cancer_Homo sapiens_hsa052160.82379945
72Oxidative phosphorylation_Homo sapiens_hsa001900.81924656
73Selenocompound metabolism_Homo sapiens_hsa004500.81919690
74Taste transduction_Homo sapiens_hsa047420.81904857
75Cholinergic synapse_Homo sapiens_hsa047250.81853063
76Wnt signaling pathway_Homo sapiens_hsa043100.81133655
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79293664
78Melanogenesis_Homo sapiens_hsa049160.78478547
79Type II diabetes mellitus_Homo sapiens_hsa049300.77581642
80Carbon metabolism_Homo sapiens_hsa012000.76275360
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75809807
82Systemic lupus erythematosus_Homo sapiens_hsa053220.75792221
83Parkinsons disease_Homo sapiens_hsa050120.75431773
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75220019
85Hedgehog signaling pathway_Homo sapiens_hsa043400.75153935
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74743316
87Basal cell carcinoma_Homo sapiens_hsa052170.71818713
88Basal transcription factors_Homo sapiens_hsa030220.71370266
89Fatty acid degradation_Homo sapiens_hsa000710.70816005
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69893752
91beta-Alanine metabolism_Homo sapiens_hsa004100.69478430
92Insulin signaling pathway_Homo sapiens_hsa049100.67952486
93Collecting duct acid secretion_Homo sapiens_hsa049660.67760817
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67024439
95Sulfur metabolism_Homo sapiens_hsa009200.66190104
96Long-term depression_Homo sapiens_hsa047300.66078175
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66071271
98Vitamin B6 metabolism_Homo sapiens_hsa007500.65952614
99Purine metabolism_Homo sapiens_hsa002300.65448120
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64692352
101AMPK signaling pathway_Homo sapiens_hsa041520.62953475
102Huntingtons disease_Homo sapiens_hsa050160.61422143
103Glutamatergic synapse_Homo sapiens_hsa047240.61125826
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60892839
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.60355684
106Viral carcinogenesis_Homo sapiens_hsa052030.60276830
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59118939
108Galactose metabolism_Homo sapiens_hsa000520.59105649
109Non-homologous end-joining_Homo sapiens_hsa034500.59049944
110Glioma_Homo sapiens_hsa052140.58656072
111Endometrial cancer_Homo sapiens_hsa052130.58235363
112Tryptophan metabolism_Homo sapiens_hsa003800.57878586
113Circadian rhythm_Homo sapiens_hsa047100.56608818
114p53 signaling pathway_Homo sapiens_hsa041150.55483783
115HTLV-I infection_Homo sapiens_hsa051660.55291617
116Metabolic pathways_Homo sapiens_hsa011000.54669487
117Thyroid hormone synthesis_Homo sapiens_hsa049180.54651896
118Fanconi anemia pathway_Homo sapiens_hsa034600.54296539
119Renin secretion_Homo sapiens_hsa049240.51873915
120Morphine addiction_Homo sapiens_hsa050320.51834381
121Fructose and mannose metabolism_Homo sapiens_hsa000510.51341677
122Arginine biosynthesis_Homo sapiens_hsa002200.50659404
123Oxytocin signaling pathway_Homo sapiens_hsa049210.50606612
124Tight junction_Homo sapiens_hsa045300.49231905
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48516522
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45857834
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45237174
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44455336
129Serotonergic synapse_Homo sapiens_hsa047260.44297465
130Gastric acid secretion_Homo sapiens_hsa049710.43550974
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.43122088
132Arginine and proline metabolism_Homo sapiens_hsa003300.43009350
133Regulation of autophagy_Homo sapiens_hsa041400.41319051
134Fatty acid biosynthesis_Homo sapiens_hsa000610.40840038
135Sulfur relay system_Homo sapiens_hsa041220.40630311
136Bladder cancer_Homo sapiens_hsa052190.40203827
137Type I diabetes mellitus_Homo sapiens_hsa049400.39353263
138Calcium signaling pathway_Homo sapiens_hsa040200.38666648
139GnRH signaling pathway_Homo sapiens_hsa049120.38573899
140Lysine degradation_Homo sapiens_hsa003100.24844277
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22481763
142Folate biosynthesis_Homo sapiens_hsa007900.22233856
143Alzheimers disease_Homo sapiens_hsa050100.20179965
144Epstein-Barr virus infection_Homo sapiens_hsa051690.19407668
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17913861
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.16854092
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12813834
148Shigellosis_Homo sapiens_hsa051310.12059176
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06881409
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04900583
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04632136
152Renin-angiotensin system_Homo sapiens_hsa046140.04472886

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