ELP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32804085
2DNA deamination (GO:0045006)4.05957884
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.03210581
4protein complex biogenesis (GO:0070271)4.01420856
5energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92925774
6ATP synthesis coupled proton transport (GO:0015986)3.92925774
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91578178
8water-soluble vitamin biosynthetic process (GO:0042364)3.91230816
9DNA strand elongation involved in DNA replication (GO:0006271)3.89372588
10respiratory chain complex IV assembly (GO:0008535)3.84718219
11mitochondrial respiratory chain complex assembly (GO:0033108)3.84150275
12DNA strand elongation (GO:0022616)3.80057501
13mitochondrial respiratory chain complex I assembly (GO:0032981)3.77640459
14NADH dehydrogenase complex assembly (GO:0010257)3.77640459
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77640459
16CENP-A containing nucleosome assembly (GO:0034080)3.60464887
17folic acid-containing compound biosynthetic process (GO:0009396)3.60391131
18DNA double-strand break processing (GO:0000729)3.58723819
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.58689218
20regulation of mitotic spindle checkpoint (GO:1903504)3.58689218
21telomere maintenance via semi-conservative replication (GO:0032201)3.57194265
22chromatin remodeling at centromere (GO:0031055)3.54203163
23protein neddylation (GO:0045116)3.49176490
24cytochrome complex assembly (GO:0017004)3.48393697
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46497654
26pteridine-containing compound biosynthetic process (GO:0042559)3.39155091
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38629727
28IMP biosynthetic process (GO:0006188)3.38530396
29viral mRNA export from host cell nucleus (GO:0046784)3.38139586
30signal peptide processing (GO:0006465)3.37490394
31rRNA modification (GO:0000154)3.36359146
32protein-cofactor linkage (GO:0018065)3.34374022
33platelet dense granule organization (GO:0060155)3.33948293
34purine nucleobase biosynthetic process (GO:0009113)3.31976930
35proteasome assembly (GO:0043248)3.31232114
36DNA replication checkpoint (GO:0000076)3.24354441
37electron transport chain (GO:0022900)3.23880913
38respiratory electron transport chain (GO:0022904)3.23021000
39DNA ligation (GO:0006266)3.22751643
40nucleobase biosynthetic process (GO:0046112)3.19930401
41transcription-coupled nucleotide-excision repair (GO:0006283)3.19179459
42DNA replication initiation (GO:0006270)3.18578261
43rRNA methylation (GO:0031167)3.17752239
44pseudouridine synthesis (GO:0001522)3.17519288
45regulation of hexokinase activity (GO:1903299)3.14733497
46regulation of glucokinase activity (GO:0033131)3.14733497
47replication fork processing (GO:0031297)3.13922141
48spliceosomal snRNP assembly (GO:0000387)3.12577903
49chaperone-mediated protein transport (GO:0072321)3.10605814
50mitotic metaphase plate congression (GO:0007080)3.10233474
51tRNA methylation (GO:0030488)3.10133483
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09676114
53regulation of mitochondrial translation (GO:0070129)3.08515338
54L-serine metabolic process (GO:0006563)3.07607405
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.07586235
56ribosome biogenesis (GO:0042254)3.07576702
57protein deneddylation (GO:0000338)3.07339249
58telomere maintenance via recombination (GO:0000722)3.07331813
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.07187595
60regulation of double-strand break repair via homologous recombination (GO:0010569)3.06913385
61DNA replication-independent nucleosome organization (GO:0034724)3.06593871
62DNA replication-independent nucleosome assembly (GO:0006336)3.06593871
63preassembly of GPI anchor in ER membrane (GO:0016254)3.05494283
64regulation of development, heterochronic (GO:0040034)3.05029888
65resolution of meiotic recombination intermediates (GO:0000712)3.04315112
66recombinational repair (GO:0000725)3.03328626
67branched-chain amino acid catabolic process (GO:0009083)3.01828071
68synapsis (GO:0007129)2.98207623
69double-strand break repair via homologous recombination (GO:0000724)2.97972633
70cellular ketone body metabolic process (GO:0046950)2.97128420
71spindle assembly checkpoint (GO:0071173)2.96792446
72intracellular protein transmembrane import (GO:0044743)2.95404633
73cullin deneddylation (GO:0010388)2.95348153
74mitotic spindle assembly checkpoint (GO:0007094)2.92157391
75nucleotide transmembrane transport (GO:1901679)2.91622487
76mitotic recombination (GO:0006312)2.90929321
77peptidyl-histidine modification (GO:0018202)2.90575867
78spindle checkpoint (GO:0031577)2.89705517
79DNA unwinding involved in DNA replication (GO:0006268)2.88727727
80metaphase plate congression (GO:0051310)2.88718075
81negative regulation of mitotic sister chromatid separation (GO:2000816)2.88213535
82negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88213535
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88213535
84negative regulation of sister chromatid segregation (GO:0033046)2.88213535
85reciprocal meiotic recombination (GO:0007131)2.88188009
86reciprocal DNA recombination (GO:0035825)2.88188009
87intraciliary transport (GO:0042073)2.86484399
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.82890221
89RNA methylation (GO:0001510)2.82439514
90IMP metabolic process (GO:0046040)2.82258517
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81816047
92RNA capping (GO:0036260)2.81537495
937-methylguanosine RNA capping (GO:0009452)2.81537495
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81423061
95attachment of spindle microtubules to kinetochore (GO:0008608)2.81150099
96negative regulation of chromosome segregation (GO:0051985)2.80876648
97DNA damage response, detection of DNA damage (GO:0042769)2.79803979
98kinetochore organization (GO:0051383)2.78949420
99regulation of spindle organization (GO:0090224)2.78825293
100nonmotile primary cilium assembly (GO:0035058)2.78519764
101lactate metabolic process (GO:0006089)2.78503998
102mismatch repair (GO:0006298)2.77218434
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75836249
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.75836249
105C-terminal protein lipidation (GO:0006501)2.75628461
106termination of RNA polymerase III transcription (GO:0006386)2.74615958
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.74615958
108methionine biosynthetic process (GO:0009086)2.73744237
109mitotic spindle checkpoint (GO:0071174)2.72730840
110fucose catabolic process (GO:0019317)2.70306989
111L-fucose metabolic process (GO:0042354)2.70306989
112L-fucose catabolic process (GO:0042355)2.70306989
113intra-S DNA damage checkpoint (GO:0031573)2.69830122
114telomere maintenance via telomere lengthening (GO:0010833)2.69626284
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69388362
116response to pheromone (GO:0019236)2.68523007
117regulation of timing of cell differentiation (GO:0048505)2.68420768
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67811304
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67145800
120ketone body metabolic process (GO:1902224)2.66937906
121histone exchange (GO:0043486)2.66827028
122kinetochore assembly (GO:0051382)2.65695105
123paraxial mesoderm development (GO:0048339)2.64800381
124maturation of 5.8S rRNA (GO:0000460)2.64519100
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64080952
1267-methylguanosine mRNA capping (GO:0006370)2.63404113
127DNA-dependent DNA replication (GO:0006261)2.63299239
128establishment of chromosome localization (GO:0051303)2.62295551
129nucleotide-excision repair (GO:0006289)2.61821506
130protein K6-linked ubiquitination (GO:0085020)2.60903273
131C-terminal protein amino acid modification (GO:0018410)2.60778232
132negative regulation of transcription by competitive promoter binding (GO:0010944)2.60746165
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60153628
134tRNA processing (GO:0008033)2.60125719
135pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57876707
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57396264
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57396264
138base-excision repair, AP site formation (GO:0006285)2.57130630
139protein K11-linked ubiquitination (GO:0070979)2.56915339
140negative regulation of mitosis (GO:0045839)2.56132505
141translesion synthesis (GO:0019985)2.55770844
142dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.55395085
143daunorubicin metabolic process (GO:0044597)2.54306700
144polyketide metabolic process (GO:0030638)2.54306700
145doxorubicin metabolic process (GO:0044598)2.54306700
146oxidative phosphorylation (GO:0006119)2.53943427
147ubiquinone metabolic process (GO:0006743)2.53750878
148postreplication repair (GO:0006301)2.53516488
149regulation of cilium movement (GO:0003352)2.52496023
150Golgi transport vesicle coating (GO:0048200)2.52387412
151COPI coating of Golgi vesicle (GO:0048205)2.52387412
152meiotic chromosome segregation (GO:0045132)2.52360385
153DNA catabolic process, exonucleolytic (GO:0000738)2.51894939
154cilium morphogenesis (GO:0060271)2.51300244
155histone H2A acetylation (GO:0043968)2.50950366
156quinone biosynthetic process (GO:1901663)2.50718876
157ubiquinone biosynthetic process (GO:0006744)2.50718876
158pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.50690501
159regulation of helicase activity (GO:0051095)2.50665344
160behavioral response to nicotine (GO:0035095)2.50662345
161mitotic chromosome condensation (GO:0007076)2.50315405
162mannosylation (GO:0097502)2.50214192
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49510409
164amino acid salvage (GO:0043102)2.49038872
165L-methionine salvage (GO:0071267)2.49038872
166L-methionine biosynthetic process (GO:0071265)2.49038872
167histone mRNA metabolic process (GO:0008334)2.47759032
168anterograde synaptic vesicle transport (GO:0048490)2.47369014
169GPI anchor metabolic process (GO:0006505)2.47037875
170ATP biosynthetic process (GO:0006754)2.45865455
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43829227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.97520232
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18241874
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75593080
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.37438878
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.34594595
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29108061
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25152368
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23688593
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19681230
10RBPJ_22232070_ChIP-Seq_NCS_Mouse3.18902405
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.12941390
12ZNF274_21170338_ChIP-Seq_K562_Hela2.97499576
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86131666
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.64422905
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63545011
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.61774072
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61452506
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.57186879
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56527753
20AR_21909140_ChIP-Seq_LNCAP_Human2.47216525
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43606370
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41863001
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39338076
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38967678
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36563806
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34124639
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32154865
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32108823
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30417824
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25344885
31IGF1R_20145208_ChIP-Seq_DFB_Human2.24848540
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.22874107
33FOXP3_21729870_ChIP-Seq_TREG_Human2.20262128
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19289012
35VDR_23849224_ChIP-Seq_CD4+_Human2.16584863
36DCP1A_22483619_ChIP-Seq_HELA_Human2.14566354
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.13188881
38ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11407657
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11303475
40MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05573674
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03150688
42TP63_19390658_ChIP-ChIP_HaCaT_Human2.01430154
43GBX2_23144817_ChIP-Seq_PC3_Human2.01260977
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96119051
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95148095
46XRN2_22483619_ChIP-Seq_HELA_Human1.94932561
47ELK1_19687146_ChIP-ChIP_HELA_Human1.91325473
48TAF15_26573619_Chip-Seq_HEK293_Human1.87319982
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84718519
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82275041
51GABP_19822575_ChIP-Seq_HepG2_Human1.80469024
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73126410
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72970681
54TTF2_22483619_ChIP-Seq_HELA_Human1.72503247
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71375743
56P300_19829295_ChIP-Seq_ESCs_Human1.69191201
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66967257
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66484934
59IRF1_19129219_ChIP-ChIP_H3396_Human1.65862239
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64397170
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.62764963
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62286616
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59662954
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57666762
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51194326
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49560749
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.49365478
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45537084
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45133631
70CIITA_25753668_ChIP-Seq_RAJI_Human1.44445582
71ER_23166858_ChIP-Seq_MCF-7_Human1.42556443
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40665269
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37532497
74TP53_22573176_ChIP-Seq_HFKS_Human1.37500621
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36874732
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33925343
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32618274
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32568225
79VDR_22108803_ChIP-Seq_LS180_Human1.29959843
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28021762
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27575677
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24206593
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20090970
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.19574251
85MYC_18940864_ChIP-ChIP_HL60_Human1.19105998
86CBP_20019798_ChIP-Seq_JUKART_Human1.19077855
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19077855
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18082440
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.18066672
90SOX2_19829295_ChIP-Seq_ESCs_Human1.17592116
91NANOG_19829295_ChIP-Seq_ESCs_Human1.17592116
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.16448319
93* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16296129
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16210215
95* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14289458
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14218864
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14066383
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13879214
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.13879214
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13597655
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13273969
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13163894
103KDM5A_27292631_Chip-Seq_BREAST_Human1.12089243
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10809132
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.09157102
106SOX17_20123909_ChIP-Seq_XEN_Mouse1.09116329
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08523171
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08133239
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07919653
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07881166
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07393605
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07327057
113SMAD4_21799915_ChIP-Seq_A2780_Human1.06736885
114BCAT_22108803_ChIP-Seq_LS180_Human1.06635703
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.05829119
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05079326
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.04982509
118HTT_18923047_ChIP-ChIP_STHdh_Human1.02613404
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01396806
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99671029
121TCF4_22108803_ChIP-Seq_LS180_Human0.99270618
122AR_20517297_ChIP-Seq_VCAP_Human0.99178248
123AR_25329375_ChIP-Seq_VCAP_Human0.99081897
124STAT3_23295773_ChIP-Seq_U87_Human0.98709417
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98375277
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.97996866
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97860668
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97328690
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96520095
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94967441
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93540932
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93079273
133* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92532862
134EWS_26573619_Chip-Seq_HEK293_Human0.86821332
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78750516
136* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78574699
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78345474
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78081883
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78015896
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.77724214
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77641086
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76816238
143NOTCH1_21737748_ChIP-Seq_TLL_Human0.76147634
144TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75653075
145FUS_26573619_Chip-Seq_HEK293_Human0.75552562
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75440440
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74310757
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.72835974
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70255433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.81151105
2MP0003806_abnormal_nucleotide_metabolis3.32592066
3MP0000566_synostosis3.15559280
4MP0003693_abnormal_embryo_hatching2.93323028
5MP0002653_abnormal_ependyma_morphology2.86804660
6MP0008058_abnormal_DNA_repair2.85392500
7MP0010094_abnormal_chromosome_stability2.80475400
8MP0002837_dystrophic_cardiac_calcinosis2.80254572
9MP0000678_abnormal_parathyroid_gland2.73056394
10MP0005646_abnormal_pituitary_gland2.70320636
11MP0010030_abnormal_orbit_morphology2.63916115
12MP0003111_abnormal_nucleus_morphology2.53273456
13MP0008007_abnormal_cellular_replicative2.47169550
14MP0008057_abnormal_DNA_replication2.42727140
15MP0004147_increased_porphyrin_level2.38621831
16MP0002102_abnormal_ear_morphology2.31845952
17MP0003077_abnormal_cell_cycle2.30938241
18MP0008932_abnormal_embryonic_tissue2.23972560
19MP0009697_abnormal_copulation2.21177591
20MP0002638_abnormal_pupillary_reflex2.18890348
21MP0000049_abnormal_middle_ear2.18652585
22MP0002938_white_spotting2.17910170
23MP0003787_abnormal_imprinting2.14680510
24MP0004957_abnormal_blastocyst_morpholog2.12203100
25MP0001529_abnormal_vocalization2.03882165
26MP0000631_abnormal_neuroendocrine_gland2.01961001
27MP0000372_irregular_coat_pigmentation1.98173081
28MP0003890_abnormal_embryonic-extraembry1.96988201
29MP0005551_abnormal_eye_electrophysiolog1.93567666
30MP0009046_muscle_twitch1.87125612
31MP0008789_abnormal_olfactory_epithelium1.84825770
32MP0003195_calcinosis1.82915504
33MP0003136_yellow_coat_color1.79799850
34MP0001293_anophthalmia1.78192851
35MP0002877_abnormal_melanocyte_morpholog1.70722882
36MP0003011_delayed_dark_adaptation1.69663950
37MP0003119_abnormal_digestive_system1.69449926
38MP0005379_endocrine/exocrine_gland_phen1.66543541
39MP0002163_abnormal_gland_morphology1.63249504
40MP0003880_abnormal_central_pattern1.62932073
41MP0001919_abnormal_reproductive_system1.61490290
42MP0008877_abnormal_DNA_methylation1.55991202
43MP0002249_abnormal_larynx_morphology1.55520367
44MP0006036_abnormal_mitochondrial_physio1.52520338
45MP0000427_abnormal_hair_cycle1.47964393
46MP0006035_abnormal_mitochondrial_morpho1.46462419
47MP0003122_maternal_imprinting1.43637109
48MP0003186_abnormal_redox_activity1.43636892
49MP0002736_abnormal_nociception_after1.42037483
50MP0001984_abnormal_olfaction1.40306368
51MP0003938_abnormal_ear_development1.38503283
52MP0008875_abnormal_xenobiotic_pharmacok1.37249725
53MP0004133_heterotaxia1.36582909
54MP0001986_abnormal_taste_sensitivity1.35635397
55MP0006072_abnormal_retinal_apoptosis1.33081168
56MP0006276_abnormal_autonomic_nervous1.28775652
57MP0003786_premature_aging1.25637811
58MP0005389_reproductive_system_phenotype1.25462437
59MP0004142_abnormal_muscle_tone1.24560801
60MP0000647_abnormal_sebaceous_gland1.24076486
61MP0001968_abnormal_touch/_nociception1.23906597
62MP0001188_hyperpigmentation1.23167760
63MP0004215_abnormal_myocardial_fiber1.22054800
64MP0002751_abnormal_autonomic_nervous1.21356242
65MP0005645_abnormal_hypothalamus_physiol1.21243957
66MP0002090_abnormal_vision1.19163133
67MP0001286_abnormal_eye_development1.18423802
68MP0003937_abnormal_limbs/digits/tail_de1.17954755
69MP0002210_abnormal_sex_determination1.17927914
70MP0002177_abnormal_outer_ear1.16348538
71MP0008872_abnormal_physiological_respon1.15879482
72MP0002132_abnormal_respiratory_system1.12588258
73MP0005171_absent_coat_pigmentation1.11229896
74MP0005365_abnormal_bile_salt1.10951642
75MP0003283_abnormal_digestive_organ1.10907432
76MP0009745_abnormal_behavioral_response1.10883387
77MP0002928_abnormal_bile_duct1.09571258
78MP0003941_abnormal_skin_development1.09269390
79MP0005394_taste/olfaction_phenotype1.08973494
80MP0005499_abnormal_olfactory_system1.08973494
81MP0001346_abnormal_lacrimal_gland1.08741140
82MP0002233_abnormal_nose_morphology1.08451354
83MP0005332_abnormal_amino_acid1.08295947
84MP0002234_abnormal_pharynx_morphology1.08022624
85MP0005248_abnormal_Harderian_gland1.07514907
86MP0004885_abnormal_endolymph1.07477764
87MP0001944_abnormal_pancreas_morphology1.07272918
88MP0005174_abnormal_tail_pigmentation1.07218227
89MP0002009_preneoplasia1.07163129
90MP0005408_hypopigmentation1.06618308
91MP0002272_abnormal_nervous_system1.05339196
92MP0005220_abnormal_exocrine_pancreas1.04784239
93MP0003315_abnormal_perineum_morphology1.04775862
94MP0002876_abnormal_thyroid_physiology1.04090098
95MP0002111_abnormal_tail_morphology1.03588099
96MP0002697_abnormal_eye_size1.03529635
97MP0003123_paternal_imprinting1.02894474
98MP0000613_abnormal_salivary_gland1.02853042
99MP0001485_abnormal_pinna_reflex1.01906459
100MP0005084_abnormal_gallbladder_morpholo1.01860189
101MP0005075_abnormal_melanosome_morpholog1.01829352
102MP0001119_abnormal_female_reproductive1.01352105
103MP0008995_early_reproductive_senescence1.00650913
104MP0002396_abnormal_hematopoietic_system0.99590583
105MP0000026_abnormal_inner_ear0.98075192
106MP0002557_abnormal_social/conspecific_i0.97128508
107MP0003121_genomic_imprinting0.96633910
108MP0000350_abnormal_cell_proliferation0.95335862
109MP0004043_abnormal_pH_regulation0.95223025
110MP0010386_abnormal_urinary_bladder0.94849814
111MP0001324_abnormal_eye_pigmentation0.94629271
112MP0001186_pigmentation_phenotype0.93604226
113MP0000681_abnormal_thyroid_gland0.92543432
114MP0003718_maternal_effect0.92006679
115MP0002092_abnormal_eye_morphology0.91627346
116MP0002116_abnormal_craniofacial_bone0.91618064
117MP0005391_vision/eye_phenotype0.91250879
118MP0000653_abnormal_sex_gland0.91072372
119MP0000428_abnormal_craniofacial_morphol0.91068571
120MP0001145_abnormal_male_reproductive0.90894287
121MP0009780_abnormal_chondrocyte_physiolo0.89702337
122MP0002085_abnormal_embryonic_tissue0.88637099
123MP0005257_abnormal_intraocular_pressure0.87437203
124MP0005187_abnormal_penis_morphology0.85622734
125MP0005195_abnormal_posterior_eye0.85085150
126MP0003698_abnormal_male_reproductive0.85049380
127MP0000358_abnormal_cell_content/0.84907432
128MP0002693_abnormal_pancreas_physiology0.84329474
129MP0000462_abnormal_digestive_system0.84328834
130MP0001929_abnormal_gametogenesis0.84319631
131MP0001697_abnormal_embryo_size0.83302588
132MP0003137_abnormal_impulse_conducting0.82800187
133MP0002095_abnormal_skin_pigmentation0.82722891
134MP0005636_abnormal_mineral_homeostasis0.82618634
135MP0002160_abnormal_reproductive_system0.81369912
136MP0003942_abnormal_urinary_system0.80040852
137MP0004924_abnormal_behavior0.79881272
138MP0005386_behavior/neurological_phenoty0.79881272
139MP0001764_abnormal_homeostasis0.79323278
140MP0005253_abnormal_eye_physiology0.78201332
141MP0003755_abnormal_palate_morphology0.77371703
142MP0001905_abnormal_dopamine_level0.77221913
143MP0000490_abnormal_crypts_of0.77169171
144MP0005410_abnormal_fertilization0.77007977
145MP0001730_embryonic_growth_arrest0.76411293
146MP0001672_abnormal_embryogenesis/_devel0.75007175
147MP0005380_embryogenesis_phenotype0.75007175
148MP0002075_abnormal_coat/hair_pigmentati0.74910335
149MP0006054_spinal_hemorrhage0.73449355
150MP0004197_abnormal_fetal_growth/weight/0.72563263

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.99972598
2Type I transferrin isoform profile (HP:0003642)3.68293723
3Birth length less than 3rd percentile (HP:0003561)3.65983213
4Progressive macrocephaly (HP:0004481)3.63565563
5Acute encephalopathy (HP:0006846)3.59919444
6Mitochondrial inheritance (HP:0001427)3.53643506
7Increased CSF lactate (HP:0002490)3.45768496
8Abnormal mitochondria in muscle tissue (HP:0008316)3.42998439
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39419520
10Chromsome breakage (HP:0040012)3.27437796
11Molar tooth sign on MRI (HP:0002419)3.26527159
12Abnormality of midbrain morphology (HP:0002418)3.26527159
13Increased hepatocellular lipid droplets (HP:0006565)3.24511335
14Lipid accumulation in hepatocytes (HP:0006561)3.09711696
153-Methylglutaconic aciduria (HP:0003535)3.05713098
16True hermaphroditism (HP:0010459)3.02173060
17Intestinal atresia (HP:0011100)3.01925829
18Nephronophthisis (HP:0000090)3.00162982
19Renal cortical cysts (HP:0000803)2.99463053
20Abnormality of the renal collecting system (HP:0004742)2.92618426
21Pancreatic fibrosis (HP:0100732)2.89457916
22Hypoglycemic seizures (HP:0002173)2.85085266
23Methylmalonic acidemia (HP:0002912)2.82549333
24Stenosis of the external auditory canal (HP:0000402)2.78479498
25Hyperinsulinemic hypoglycemia (HP:0000825)2.75011359
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70785988
27Abnormal protein N-linked glycosylation (HP:0012347)2.70785988
28Abnormal protein glycosylation (HP:0012346)2.70785988
29Abnormal glycosylation (HP:0012345)2.70785988
30Cerebral edema (HP:0002181)2.66238166
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.61671720
32Hypoglycemic coma (HP:0001325)2.59173902
33Abnormality of the labia minora (HP:0012880)2.55258805
34Microvesicular hepatic steatosis (HP:0001414)2.53368082
35Colon cancer (HP:0003003)2.52674819
36Renal Fanconi syndrome (HP:0001994)2.51058824
37Pancreatic cysts (HP:0001737)2.50913074
38Abnormality of alanine metabolism (HP:0010916)2.50597870
39Hyperalaninemia (HP:0003348)2.50597870
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50597870
41Abnormality of the renal cortex (HP:0011035)2.49125918
42Abnormality of the renal medulla (HP:0100957)2.47702926
43Symptomatic seizures (HP:0011145)2.45571729
44Hypothermia (HP:0002045)2.36003063
45Congenital stationary night blindness (HP:0007642)2.34050146
46Lactic acidosis (HP:0003128)2.32988720
47Optic disc pallor (HP:0000543)2.29528097
48Abnormality of the metopic suture (HP:0005556)2.23810144
49Preaxial hand polydactyly (HP:0001177)2.22215304
50Hypoplastic labia majora (HP:0000059)2.22207540
51Abnormality of the preputium (HP:0100587)2.21507799
52Bile duct proliferation (HP:0001408)2.19155915
53Abnormal biliary tract physiology (HP:0012439)2.19155915
54Sclerocornea (HP:0000647)2.18418588
55Prominent metopic ridge (HP:0005487)2.17860302
56Methylmalonic aciduria (HP:0012120)2.15635447
57Abnormal lung lobation (HP:0002101)2.14823422
58Abolished electroretinogram (ERG) (HP:0000550)2.14442474
59Breast hypoplasia (HP:0003187)2.12892640
60Nephroblastoma (Wilms tumor) (HP:0002667)2.12861557
61Meckel diverticulum (HP:0002245)2.11448305
62Respiratory failure (HP:0002878)2.08872823
63Embryonal renal neoplasm (HP:0011794)2.08849127
64Ketoacidosis (HP:0001993)2.08746598
65Duplicated collecting system (HP:0000081)2.08121141
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07843551
67Large for gestational age (HP:0001520)2.06806457
68Reticulocytopenia (HP:0001896)2.04963403
69Abnormality of the ileum (HP:0001549)2.04919841
70Lethargy (HP:0001254)2.03446787
71Abnormality of the labia majora (HP:0012881)2.03052528
72Septo-optic dysplasia (HP:0100842)2.01801319
73Abnormality of chromosome stability (HP:0003220)2.01014755
74Carpal bone hypoplasia (HP:0001498)2.01009503
75Premature graying of hair (HP:0002216)2.00961027
76Degeneration of anterior horn cells (HP:0002398)2.00623574
77Abnormality of the anterior horn cell (HP:0006802)2.00623574
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00353591
79Impulsivity (HP:0100710)1.99800204
80Hepatic necrosis (HP:0002605)1.99369563
81Tubular atrophy (HP:0000092)1.99334737
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98804765
83Optic nerve coloboma (HP:0000588)1.97956573
84Attenuation of retinal blood vessels (HP:0007843)1.97476894
85Congenital, generalized hypertrichosis (HP:0004540)1.97027674
86Split foot (HP:0001839)1.96610202
87Genital tract atresia (HP:0001827)1.96229008
88Type 2 muscle fiber atrophy (HP:0003554)1.95784798
89Type II lissencephaly (HP:0007260)1.95180306
90Hyperglycinuria (HP:0003108)1.94618773
91Clitoromegaly (HP:0000057)1.94526181
9211 pairs of ribs (HP:0000878)1.93923896
93Short middle phalanx of the 5th finger (HP:0004220)1.93876591
94Increased serum lactate (HP:0002151)1.93691345
95Pendular nystagmus (HP:0012043)1.93517861
96Osteomalacia (HP:0002749)1.92881328
97Generalized aminoaciduria (HP:0002909)1.91302164
98Abnormality of serum amino acid levels (HP:0003112)1.89968037
99Congenital primary aphakia (HP:0007707)1.89844858
100Hyperglycinemia (HP:0002154)1.89471469
101Chronic hepatic failure (HP:0100626)1.88867848
102Aplasia/hypoplasia of the uterus (HP:0008684)1.88455756
103Abnormality of the clitoris (HP:0000056)1.87675290
104Facial cleft (HP:0002006)1.87562036
105Vaginal atresia (HP:0000148)1.87491861
106Nephrogenic diabetes insipidus (HP:0009806)1.87295701
107Increased serum pyruvate (HP:0003542)1.86345916
108Abnormality of vitamin B metabolism (HP:0004340)1.86095625
109Aplasia/Hypoplasia of the patella (HP:0006498)1.85703619
110Medial flaring of the eyebrow (HP:0010747)1.84996351
111Aortic regurgitation (HP:0001659)1.84734887
112Abnormality of serine family amino acid metabolism (HP:0010894)1.83437228
113Abnormality of glycine metabolism (HP:0010895)1.83437228
114Adrenal hypoplasia (HP:0000835)1.83389791
115Pancreatic islet-cell hyperplasia (HP:0004510)1.83363315
116Patellar aplasia (HP:0006443)1.83082674
117Glycosuria (HP:0003076)1.82739611
118Abnormality of urine glucose concentration (HP:0011016)1.82739611
119Abnormality of homocysteine metabolism (HP:0010919)1.82475629
120Homocystinuria (HP:0002156)1.82475629
121Congenital hepatic fibrosis (HP:0002612)1.80390135
122Ectopic kidney (HP:0000086)1.79861472
123Leukodystrophy (HP:0002415)1.79761946
124Progressive inability to walk (HP:0002505)1.79472745
125Abnormality of renal resorption (HP:0011038)1.79254004
126Ketosis (HP:0001946)1.79246870
127Aplastic anemia (HP:0001915)1.79019644
128Abnormality of the carotid arteries (HP:0005344)1.78743324
129Male pseudohermaphroditism (HP:0000037)1.78021129
130Furrowed tongue (HP:0000221)1.76984752
131Conjugated hyperbilirubinemia (HP:0002908)1.75849978
132Aplasia involving forearm bones (HP:0009822)1.75342936
133Absent forearm bone (HP:0003953)1.75342936
134Absent radius (HP:0003974)1.75160196
135Triphalangeal thumb (HP:0001199)1.74964545
136Hepatocellular necrosis (HP:0001404)1.74563045
137Abnormality of methionine metabolism (HP:0010901)1.74526722
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.74399618
139Polydipsia (HP:0001959)1.73545456
140Abnormal drinking behavior (HP:0030082)1.73545456
141Hemiparesis (HP:0001269)1.73163061
142Postaxial foot polydactyly (HP:0001830)1.73064521
143Anencephaly (HP:0002323)1.72753559
144Missing ribs (HP:0000921)1.72155424
145Abnormality of the duodenum (HP:0002246)1.71267068
146Brushfield spots (HP:0001088)1.68845997
147Sloping forehead (HP:0000340)1.68013691
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.67097785
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67044420
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67044420
151Gait imbalance (HP:0002141)1.65128452
152Muscle fiber atrophy (HP:0100295)1.63855329
153Small intestinal stenosis (HP:0012848)1.63735564
154Duodenal stenosis (HP:0100867)1.63735564
155Cystic liver disease (HP:0006706)1.63019567
156Gastrointestinal atresia (HP:0002589)1.62755706
157Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61954686
158Generalized hypopigmentation of hair (HP:0011358)1.60704817
159Hemivertebrae (HP:0002937)1.60306083
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60247300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.50979265
2PRKD33.08414772
3MST43.05255771
4SRPK13.03047328
5PASK2.85442686
6BMPR1B2.77209561
7STK162.67849806
8MAP4K22.58200772
9EIF2AK32.56347983
10MKNK12.53083915
11VRK12.49215583
12WEE12.48969407
13EIF2AK12.48134901
14VRK22.40333557
15NUAK12.40223223
16PLK42.24122414
17BCKDK2.15406069
18ZAK2.06377007
19CDC72.01919739
20ACVR1B1.94391971
21STK38L1.93138420
22TNIK1.84849898
23TESK21.84579450
24INSRR1.82914630
25BRSK21.81696007
26SCYL21.80685550
27NEK11.75575133
28YES11.71442087
29CASK1.66502294
30PBK1.64078076
31TRIM281.63480620
32TTK1.59081154
33SIK31.55958656
34MAPK131.53161890
35EIF2AK21.50567395
36BCR1.48422527
37BRD41.46910900
38WNK41.46573466
39MKNK21.46012525
40PLK31.43351612
41ERBB31.40592247
42ATR1.33473917
43PLK11.31029970
44NME11.30865175
45DYRK21.29707373
46MAPK151.26097207
47CSNK1G21.25955722
48CSNK1G11.25266020
49AURKA1.25090102
50NEK61.23944973
51MAP3K41.20289917
52CHEK21.20024685
53BRSK11.17814336
54IRAK31.17652375
55PLK21.16578451
56FGFR21.13886779
57CDK71.13162439
58PNCK1.12391742
59TLK11.10819221
60RPS6KB21.07565504
61STK391.02368390
62PAK30.99348254
63CSNK1A1L0.97490085
64AURKB0.97359746
65OXSR10.95030737
66NEK20.93289158
67TAOK20.87709636
68EPHA30.86501907
69PINK10.83587740
70SGK20.83052534
71MAP3K120.82422112
72STK30.81098911
73TAF10.80118650
74CDK80.79179794
75RPS6KB10.77716982
76PHKG10.77376467
77PHKG20.77376467
78NME20.74974263
79TAOK30.74178220
80CDK190.71242701
81MUSK0.70963483
82NLK0.70503262
83PRKCE0.70052170
84AKT30.69952780
85LIMK10.68659824
86PRKCG0.68524940
87CHEK10.67945412
88ATM0.67206583
89IRAK10.67206189
90NEK90.66826747
91DYRK30.66717927
92FLT30.63621615
93HIPK20.62807482
94MAPKAPK30.62784631
95EPHA40.62758967
96PIK3CG0.61931312
97SGK2230.60941379
98SGK4940.60941379
99TSSK60.60613772
100ERBB40.59607306
101MAP2K60.58689637
102CDK10.57067437
103CSNK2A10.56898513
104CDK30.56532867
105WNK30.54273350
106CDK20.52890590
107TGFBR10.50451335
108CCNB10.49808169
109FER0.48397986
110RPS6KA40.48311213
111MELK0.47223263
112IRAK20.45870510
113ADRBK10.44907724
114STK40.44576817
115BMPR20.43784286
116TIE10.42382039
117STK100.41864343
118PRKCI0.40950227
119CSNK1A10.39769769
120PDK20.37224878
121OBSCN0.36908308
122CSNK1G30.35349513
123NTRK30.35201960
124MAP2K70.34586786
125PRKACB0.34127035
126CSNK2A20.33936439
127CAMK2A0.33363794
128RPS6KA50.33253645
129FRK0.32738778
130ADRBK20.32352797
131CAMK2D0.31635942
132BRAF0.30803197
133MINK10.30286732
134PRKD20.29566409
135GRK10.29283717
136CHUK0.29212864
137PRKACA0.28965184
138MAPK140.28392599
139TEC0.28012388
140UHMK10.27918587
141MAPKAPK50.27091294
142SIK10.25965185
143AKT10.25823419

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80871356
2Mismatch repair_Homo sapiens_hsa034303.72247743
3Protein export_Homo sapiens_hsa030603.49491202
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.18317942
5Base excision repair_Homo sapiens_hsa034102.85686456
6RNA polymerase_Homo sapiens_hsa030202.74532679
7One carbon pool by folate_Homo sapiens_hsa006702.65494555
8Homologous recombination_Homo sapiens_hsa034402.60361969
9Proteasome_Homo sapiens_hsa030502.45711107
10Nucleotide excision repair_Homo sapiens_hsa034202.45424213
11Spliceosome_Homo sapiens_hsa030402.37769135
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35332515
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34197634
14Pyrimidine metabolism_Homo sapiens_hsa002402.21537417
15Sulfur metabolism_Homo sapiens_hsa009202.19591089
16Cell cycle_Homo sapiens_hsa041102.18862861
17Fanconi anemia pathway_Homo sapiens_hsa034602.17180799
18RNA transport_Homo sapiens_hsa030132.06160281
19Non-homologous end-joining_Homo sapiens_hsa034501.96985989
20Selenocompound metabolism_Homo sapiens_hsa004501.95900669
21Folate biosynthesis_Homo sapiens_hsa007901.88619313
22Basal transcription factors_Homo sapiens_hsa030221.81456701
23Alzheimers disease_Homo sapiens_hsa050101.71759432
24Ribosome_Homo sapiens_hsa030101.67401824
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66117172
26RNA degradation_Homo sapiens_hsa030181.61680446
27N-Glycan biosynthesis_Homo sapiens_hsa005101.55252705
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53342571
29Phototransduction_Homo sapiens_hsa047441.52851129
30Peroxisome_Homo sapiens_hsa041461.40101863
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39225714
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38659446
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33252412
34Purine metabolism_Homo sapiens_hsa002301.30950435
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.30054606
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24890977
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21645035
38mRNA surveillance pathway_Homo sapiens_hsa030151.14949567
39Cardiac muscle contraction_Homo sapiens_hsa042601.09493684
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07598098
41Fatty acid elongation_Homo sapiens_hsa000621.07591089
42p53 signaling pathway_Homo sapiens_hsa041151.03714160
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02236131
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.97979063
45Propanoate metabolism_Homo sapiens_hsa006400.96199562
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95109962
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94741342
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92064630
49Basal cell carcinoma_Homo sapiens_hsa052170.90963774
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87499634
51Pyruvate metabolism_Homo sapiens_hsa006200.87468442
52Vitamin B6 metabolism_Homo sapiens_hsa007500.85568050
53Caffeine metabolism_Homo sapiens_hsa002320.83871622
54Galactose metabolism_Homo sapiens_hsa000520.81238657
55Glutathione metabolism_Homo sapiens_hsa004800.79674360
56Sulfur relay system_Homo sapiens_hsa041220.77902415
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77093884
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76848088
59Systemic lupus erythematosus_Homo sapiens_hsa053220.76603633
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73670790
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73637084
62Fatty acid degradation_Homo sapiens_hsa000710.71184582
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67804564
64Metabolic pathways_Homo sapiens_hsa011000.67425321
65Nicotine addiction_Homo sapiens_hsa050330.66453024
66Ether lipid metabolism_Homo sapiens_hsa005650.66014353
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65656785
68Steroid biosynthesis_Homo sapiens_hsa001000.64574300
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64384875
70Collecting duct acid secretion_Homo sapiens_hsa049660.63254539
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62671761
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62180170
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62029484
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61867226
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61648498
76Regulation of autophagy_Homo sapiens_hsa041400.61196268
77Linoleic acid metabolism_Homo sapiens_hsa005910.58987400
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56658192
79Fatty acid metabolism_Homo sapiens_hsa012120.55946094
80Alcoholism_Homo sapiens_hsa050340.55363996
81Tryptophan metabolism_Homo sapiens_hsa003800.52585332
82Butanoate metabolism_Homo sapiens_hsa006500.52065219
83Other glycan degradation_Homo sapiens_hsa005110.51920455
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51668150
85Arachidonic acid metabolism_Homo sapiens_hsa005900.51600771
86Huntingtons disease_Homo sapiens_hsa050160.51212992
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50363866
88Oocyte meiosis_Homo sapiens_hsa041140.48224346
89Chemical carcinogenesis_Homo sapiens_hsa052040.47477886
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.46658712
91Epstein-Barr virus infection_Homo sapiens_hsa051690.46346848
92Taste transduction_Homo sapiens_hsa047420.45934459
93Insulin secretion_Homo sapiens_hsa049110.43216143
94Olfactory transduction_Homo sapiens_hsa047400.42837421
95Pentose phosphate pathway_Homo sapiens_hsa000300.42652434
96Circadian rhythm_Homo sapiens_hsa047100.42143505
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.41283937
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40794998
99Starch and sucrose metabolism_Homo sapiens_hsa005000.40697154
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40485271
101Tyrosine metabolism_Homo sapiens_hsa003500.38155898
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37810970
103Herpes simplex infection_Homo sapiens_hsa051680.37467762
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36911202
105beta-Alanine metabolism_Homo sapiens_hsa004100.35864952
106Hedgehog signaling pathway_Homo sapiens_hsa043400.35692539
107Biosynthesis of amino acids_Homo sapiens_hsa012300.34372001
108Parkinsons disease_Homo sapiens_hsa050120.33468796
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.33348304
110Retinol metabolism_Homo sapiens_hsa008300.32727644
111Arginine and proline metabolism_Homo sapiens_hsa003300.31360705
112Carbon metabolism_Homo sapiens_hsa012000.30732427
113ABC transporters_Homo sapiens_hsa020100.29758720
114Wnt signaling pathway_Homo sapiens_hsa043100.26962685
115Phenylalanine metabolism_Homo sapiens_hsa003600.26212211
116Fat digestion and absorption_Homo sapiens_hsa049750.25459288
117Nitrogen metabolism_Homo sapiens_hsa009100.25305908
118Oxidative phosphorylation_Homo sapiens_hsa001900.24937451
119Hippo signaling pathway_Homo sapiens_hsa043900.24114240
120Mineral absorption_Homo sapiens_hsa049780.22987744
121GABAergic synapse_Homo sapiens_hsa047270.22869732
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21751619

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