

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cullin deneddylation (GO:0010388) | 5.14047764 |
| 2 | proteasome assembly (GO:0043248) | 5.05147090 |
| 3 | protein deneddylation (GO:0000338) | 4.85422008 |
| 4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.76156517 |
| 5 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.56158490 |
| 6 | oxidative phosphorylation (GO:0006119) | 4.55198851 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.51030704 |
| 8 | 7-methylguanosine mRNA capping (GO:0006370) | 4.47915567 |
| 9 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.44356662 |
| 10 | RNA capping (GO:0036260) | 4.38611703 |
| 11 | 7-methylguanosine RNA capping (GO:0009452) | 4.38611703 |
| 12 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.38602403 |
| 13 | negative regulation of ligase activity (GO:0051352) | 4.38299238 |
| 14 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.38299238 |
| 15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.35705385 |
| 16 | ATP synthesis coupled proton transport (GO:0015986) | 4.35705385 |
| 17 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.35162914 |
| 18 | protein neddylation (GO:0045116) | 4.33051530 |
| 19 | chaperone-mediated protein transport (GO:0072321) | 4.32314780 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.30962466 |
| 21 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.24034128 |
| 22 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.24034128 |
| 23 | termination of RNA polymerase III transcription (GO:0006386) | 4.23755697 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.23755697 |
| 25 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.22566019 |
| 26 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.22566019 |
| 27 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.22566019 |
| 28 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.11388056 |
| 29 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.11388056 |
| 30 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.08583793 |
| 31 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 4.01920978 |
| 32 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.86835566 |
| 33 | positive regulation of ligase activity (GO:0051351) | 3.83140711 |
| 34 | pseudouridine synthesis (GO:0001522) | 3.73880653 |
| 35 | formation of translation preinitiation complex (GO:0001731) | 3.71954930 |
| 36 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.69629007 |
| 37 | DNA damage response, detection of DNA damage (GO:0042769) | 3.63810370 |
| 38 | kinetochore assembly (GO:0051382) | 3.61250526 |
| 39 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.60766138 |
| 40 | rRNA modification (GO:0000154) | 3.60313547 |
| 41 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.58993871 |
| 42 | respiratory chain complex IV assembly (GO:0008535) | 3.58021511 |
| 43 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.57225213 |
| 44 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.55793296 |
| 45 | DNA strand elongation (GO:0022616) | 3.55494005 |
| 46 | spliceosomal snRNP assembly (GO:0000387) | 3.54739195 |
| 47 | cytochrome complex assembly (GO:0017004) | 3.52182492 |
| 48 | DNA deamination (GO:0045006) | 3.51942448 |
| 49 | ribosomal large subunit biogenesis (GO:0042273) | 3.49215540 |
| 50 | protein targeting to mitochondrion (GO:0006626) | 3.46508375 |
| 51 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.46135390 |
| 52 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.46135390 |
| 53 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.44572686 |
| 54 | regulation of ligase activity (GO:0051340) | 3.43387993 |
| 55 | maturation of SSU-rRNA (GO:0030490) | 3.43220524 |
| 56 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.43203754 |
| 57 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.41582224 |
| 58 | establishment of protein localization to mitochondrion (GO:0072655) | 3.41256840 |
| 59 | histone arginine methylation (GO:0034969) | 3.40472187 |
| 60 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.40142484 |
| 61 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.38060790 |
| 62 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.37647750 |
| 63 | kinetochore organization (GO:0051383) | 3.36913346 |
| 64 | positive regulation of cell cycle arrest (GO:0071158) | 3.34775242 |
| 65 | purine nucleobase biosynthetic process (GO:0009113) | 3.32714937 |
| 66 | chromatin remodeling at centromere (GO:0031055) | 3.32513724 |
| 67 | mitotic metaphase plate congression (GO:0007080) | 3.31921725 |
| 68 | metallo-sulfur cluster assembly (GO:0031163) | 3.29556777 |
| 69 | iron-sulfur cluster assembly (GO:0016226) | 3.29556777 |
| 70 | protein complex biogenesis (GO:0070271) | 3.28721698 |
| 71 | viral transcription (GO:0019083) | 3.28542522 |
| 72 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.28244668 |
| 73 | ATP biosynthetic process (GO:0006754) | 3.26964673 |
| 74 | microtubule depolymerization (GO:0007019) | 3.26386148 |
| 75 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.25713852 |
| 76 | GTP biosynthetic process (GO:0006183) | 3.25074186 |
| 77 | protein K6-linked ubiquitination (GO:0085020) | 3.25051541 |
| 78 | ribosomal small subunit assembly (GO:0000028) | 3.24364511 |
| 79 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.24182290 |
| 80 | NADH dehydrogenase complex assembly (GO:0010257) | 3.23655219 |
| 81 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.23655219 |
| 82 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.23655219 |
| 83 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.23572197 |
| 84 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.23462900 |
| 85 | regulation of mitochondrial translation (GO:0070129) | 3.22677385 |
| 86 | regulation of cellular amine metabolic process (GO:0033238) | 3.22350510 |
| 87 | protein localization to mitochondrion (GO:0070585) | 3.21534799 |
| 88 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.20154410 |
| 89 | translational termination (GO:0006415) | 3.17940392 |
| 90 | nucleobase biosynthetic process (GO:0046112) | 3.16243746 |
| 91 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.15909984 |
| 92 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.15583207 |
| 93 | ribosome biogenesis (GO:0042254) | 3.15159746 |
| 94 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.14948925 |
| 95 | base-excision repair (GO:0006284) | 3.14644819 |
| 96 | mitochondrial RNA metabolic process (GO:0000959) | 3.13054612 |
| 97 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.12074921 |
| 98 | de novo protein folding (GO:0006458) | 3.10326774 |
| 99 | transcription from RNA polymerase I promoter (GO:0006360) | 3.09836853 |
| 100 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.09044788 |
| 101 | termination of RNA polymerase I transcription (GO:0006363) | 3.08819497 |
| 102 | de novo posttranslational protein folding (GO:0051084) | 3.07674817 |
| 103 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.07562126 |
| 104 | DNA-templated transcription, elongation (GO:0006354) | 3.07077183 |
| 105 | cotranslational protein targeting to membrane (GO:0006613) | 3.06862440 |
| 106 | inner mitochondrial membrane organization (GO:0007007) | 3.06070134 |
| 107 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.06004671 |
| 108 | positive regulation of viral transcription (GO:0050434) | 3.03160433 |
| 109 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.03084364 |
| 110 | cell cycle G1/S phase transition (GO:0044843) | 3.03084364 |
| 111 | establishment of viral latency (GO:0019043) | 3.03017007 |
| 112 | respiratory electron transport chain (GO:0022904) | 3.01423984 |
| 113 | protein targeting to ER (GO:0045047) | 3.01055289 |
| 114 | translational elongation (GO:0006414) | 3.01045193 |
| 115 | CTP metabolic process (GO:0046036) | 3.00907151 |
| 116 | CTP biosynthetic process (GO:0006241) | 3.00907151 |
| 117 | rRNA processing (GO:0006364) | 3.00637674 |
| 118 | translation (GO:0006412) | 3.00123127 |
| 119 | blastocyst development (GO:0001824) | 2.99930151 |
| 120 | cellular component biogenesis (GO:0044085) | 2.99681623 |
| 121 | CENP-A containing nucleosome assembly (GO:0034080) | 2.99267631 |
| 122 | signal transduction in response to DNA damage (GO:0042770) | 2.98756062 |
| 123 | DNA replication checkpoint (GO:0000076) | 2.98524087 |
| 124 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.98071795 |
| 125 | regulation of helicase activity (GO:0051095) | 2.97459316 |
| 126 | ribosome assembly (GO:0042255) | 2.96944613 |
| 127 | ribosomal small subunit biogenesis (GO:0042274) | 2.96540741 |
| 128 | negative regulation of protein ubiquitination (GO:0031397) | 2.96304290 |
| 129 | electron transport chain (GO:0022900) | 2.96251012 |
| 130 | peptidyl-histidine modification (GO:0018202) | 2.95838241 |
| 131 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.95441933 |
| 132 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.95441933 |
| 133 | establishment of integrated proviral latency (GO:0075713) | 2.94912260 |
| 134 | rRNA metabolic process (GO:0016072) | 2.90988090 |
| 135 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.90338443 |
| 136 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.90304023 |
| 137 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.90304023 |
| 138 | UTP biosynthetic process (GO:0006228) | 2.89664656 |
| 139 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.89430831 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.92143369 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.40873692 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.18842904 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.17277464 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.86739887 |
| 6 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.72756567 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.69861565 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.63651203 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.61444048 |
| 10 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.18397674 |
| 11 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.16837258 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.15719538 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.06311157 |
| 14 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 3.02951002 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.02373195 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.93788359 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.90089961 |
| 18 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.68695890 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.63598777 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.63180608 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.53213212 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.52779228 |
| 23 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.35186515 |
| 24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.29408577 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.28659782 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.25205079 |
| 27 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.19017617 |
| 28 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.15406820 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.14090369 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.10488161 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.09521953 |
| 32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.05251716 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.03855219 |
| 34 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.96379058 |
| 35 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.96241298 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.95846673 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.93851702 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.91209808 |
| 39 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.88445354 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.86493865 |
| 41 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.81955340 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.79775959 |
| 43 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.75722432 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.73211793 |
| 45 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.72172289 |
| 46 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.67105987 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.65934580 |
| 48 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.53630412 |
| 49 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53455057 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.47846865 |
| 51 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41394349 |
| 52 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.40819982 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.32830989 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.29189552 |
| 55 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.27874653 |
| 56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26967992 |
| 57 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.26678329 |
| 58 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22750598 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.21175508 |
| 60 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.18593501 |
| 61 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.18139823 |
| 62 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.17739754 |
| 63 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.17556726 |
| 64 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.13089836 |
| 65 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11234083 |
| 66 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.10617667 |
| 67 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.10089719 |
| 68 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.06549018 |
| 69 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06394715 |
| 70 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06380973 |
| 71 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.04316701 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.03342960 |
| 73 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.02668888 |
| 74 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.01929184 |
| 75 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97931708 |
| 76 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.95718734 |
| 77 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95359722 |
| 78 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.94137221 |
| 79 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.93148426 |
| 80 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92975877 |
| 81 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.92888777 |
| 82 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91847676 |
| 83 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91759724 |
| 84 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.91742257 |
| 85 | VDR_22108803_ChIP-Seq_LS180_Human | 0.91621532 |
| 86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.90482355 |
| 87 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90211477 |
| 88 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89872834 |
| 89 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.89664138 |
| 90 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.89122612 |
| 91 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.88933384 |
| 92 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.88515025 |
| 93 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.87722672 |
| 94 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.82821171 |
| 95 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.82288248 |
| 96 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.81923579 |
| 97 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.81895500 |
| 98 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.80969873 |
| 99 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.80753641 |
| 100 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.79985672 |
| 101 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78944553 |
| 102 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.78212479 |
| 103 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.77246091 |
| 104 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76869497 |
| 105 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.76136627 |
| 106 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.75713236 |
| 107 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.74647906 |
| 108 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74048636 |
| 109 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.72531963 |
| 110 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71882612 |
| 111 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.71221503 |
| 112 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.70117972 |
| 113 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.69789996 |
| 114 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.68542842 |
| 115 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.68450380 |
| 116 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.68243096 |
| 117 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.67861503 |
| 118 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.67516320 |
| 119 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.67480901 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 3.69121236 |
| 2 | MP0002234_abnormal_pharynx_morphology | 3.38342620 |
| 3 | MP0001529_abnormal_vocalization | 3.25396501 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.04188227 |
| 5 | MP0008058_abnormal_DNA_repair | 2.82385020 |
| 6 | MP0008057_abnormal_DNA_replication | 2.78186464 |
| 7 | MP0008877_abnormal_DNA_methylation | 2.74857511 |
| 8 | MP0003077_abnormal_cell_cycle | 2.65967580 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.57301681 |
| 10 | MP0010094_abnormal_chromosome_stability | 2.49973869 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.45317491 |
| 12 | MP0003123_paternal_imprinting | 2.36983728 |
| 13 | MP0003880_abnormal_central_pattern | 2.34560438 |
| 14 | MP0005410_abnormal_fertilization | 2.33516371 |
| 15 | MP0003718_maternal_effect | 2.26635216 |
| 16 | MP0006292_abnormal_olfactory_placode | 2.08796007 |
| 17 | MP0001905_abnormal_dopamine_level | 2.07357478 |
| 18 | MP0008007_abnormal_cellular_replicative | 1.97000449 |
| 19 | MP0002736_abnormal_nociception_after | 1.96144830 |
| 20 | MP0002163_abnormal_gland_morphology | 1.95299160 |
| 21 | MP0002653_abnormal_ependyma_morphology | 1.93689147 |
| 22 | MP0002638_abnormal_pupillary_reflex | 1.92765101 |
| 23 | MP0008260_abnormal_autophagy | 1.89843022 |
| 24 | MP0002102_abnormal_ear_morphology | 1.89006042 |
| 25 | MP0003646_muscle_fatigue | 1.83496840 |
| 26 | MP0002822_catalepsy | 1.81858967 |
| 27 | MP0010386_abnormal_urinary_bladder | 1.80976055 |
| 28 | MP0003122_maternal_imprinting | 1.78943194 |
| 29 | MP0009379_abnormal_foot_pigmentation | 1.76922277 |
| 30 | MP0006276_abnormal_autonomic_nervous | 1.72367918 |
| 31 | MP0003786_premature_aging | 1.68087598 |
| 32 | MP0001188_hyperpigmentation | 1.62277002 |
| 33 | MP0001968_abnormal_touch/_nociception | 1.61932084 |
| 34 | MP0001764_abnormal_homeostasis | 1.61723876 |
| 35 | MP0003121_genomic_imprinting | 1.55287443 |
| 36 | MP0008995_early_reproductive_senescence | 1.52390912 |
| 37 | MP0002210_abnormal_sex_determination | 1.45482231 |
| 38 | MP0002249_abnormal_larynx_morphology | 1.44156320 |
| 39 | MP0001346_abnormal_lacrimal_gland | 1.41521725 |
| 40 | MP0001929_abnormal_gametogenesis | 1.38404517 |
| 41 | MP0003315_abnormal_perineum_morphology | 1.35965389 |
| 42 | MP0002160_abnormal_reproductive_system | 1.33958384 |
| 43 | MP0006072_abnormal_retinal_apoptosis | 1.33409523 |
| 44 | MP0001293_anophthalmia | 1.31941068 |
| 45 | MP0009697_abnormal_copulation | 1.30971819 |
| 46 | MP0001730_embryonic_growth_arrest | 1.29820995 |
| 47 | MP0003698_abnormal_male_reproductive | 1.29767835 |
| 48 | MP0000678_abnormal_parathyroid_gland | 1.29698201 |
| 49 | MP0008789_abnormal_olfactory_epithelium | 1.29539752 |
| 50 | MP0009333_abnormal_splenocyte_physiolog | 1.29010018 |
| 51 | MP0003136_yellow_coat_color | 1.27928187 |
| 52 | MP0002734_abnormal_mechanical_nocicepti | 1.24512832 |
| 53 | MP0002735_abnormal_chemical_nociception | 1.23198301 |
| 54 | MP0005645_abnormal_hypothalamus_physiol | 1.22566310 |
| 55 | MP0006035_abnormal_mitochondrial_morpho | 1.22549380 |
| 56 | MP0001986_abnormal_taste_sensitivity | 1.20744891 |
| 57 | MP0003186_abnormal_redox_activity | 1.17297664 |
| 58 | MP0000015_abnormal_ear_pigmentation | 1.17182567 |
| 59 | MP0000350_abnormal_cell_proliferation | 1.13952180 |
| 60 | MP0001145_abnormal_male_reproductive | 1.13514246 |
| 61 | MP0002751_abnormal_autonomic_nervous | 1.09532179 |
| 62 | MP0001727_abnormal_embryo_implantation | 1.08098539 |
| 63 | MP0006036_abnormal_mitochondrial_physio | 1.07411047 |
| 64 | MP0001984_abnormal_olfaction | 1.03392982 |
| 65 | MP0005389_reproductive_system_phenotype | 1.02748911 |
| 66 | MP0005499_abnormal_olfactory_system | 0.99869716 |
| 67 | MP0005394_taste/olfaction_phenotype | 0.99869716 |
| 68 | MP0003567_abnormal_fetal_cardiomyocyte | 0.99328459 |
| 69 | MP0003806_abnormal_nucleotide_metabolis | 0.99170204 |
| 70 | MP0003941_abnormal_skin_development | 0.99072657 |
| 71 | MP0000653_abnormal_sex_gland | 0.98515274 |
| 72 | MP0002233_abnormal_nose_morphology | 0.98040779 |
| 73 | MP0009046_muscle_twitch | 0.96726657 |
| 74 | MP0000372_irregular_coat_pigmentation | 0.96438617 |
| 75 | MP0003937_abnormal_limbs/digits/tail_de | 0.96201781 |
| 76 | MP0001661_extended_life_span | 0.95685999 |
| 77 | MP0000778_abnormal_nervous_system | 0.94273306 |
| 78 | MP0000566_synostosis | 0.92249415 |
| 79 | MP0002132_abnormal_respiratory_system | 0.91676210 |
| 80 | MP0004142_abnormal_muscle_tone | 0.91113733 |
| 81 | MP0002184_abnormal_innervation | 0.91034430 |
| 82 | MP0003221_abnormal_cardiomyocyte_apopto | 0.90092709 |
| 83 | MP0002085_abnormal_embryonic_tissue | 0.88682857 |
| 84 | MP0005330_cardiomyopathy | 0.88400291 |
| 85 | MP0002277_abnormal_respiratory_mucosa | 0.88057337 |
| 86 | MP0001440_abnormal_grooming_behavior | 0.85261420 |
| 87 | MP0003938_abnormal_ear_development | 0.84142702 |
| 88 | MP0005171_absent_coat_pigmentation | 0.83970452 |
| 89 | MP0002064_seizures | 0.83854966 |
| 90 | MP0000313_abnormal_cell_death | 0.83561487 |
| 91 | MP0002837_dystrophic_cardiac_calcinosis | 0.83069077 |
| 92 | MP0004147_increased_porphyrin_level | 0.82859761 |
| 93 | MP0005423_abnormal_somatic_nervous | 0.82168764 |
| 94 | MP0004742_abnormal_vestibular_system | 0.81997694 |
| 95 | MP0010030_abnormal_orbit_morphology | 0.81322785 |
| 96 | MP0002161_abnormal_fertility/fecundity | 0.80792480 |
| 97 | MP0005084_abnormal_gallbladder_morpholo | 0.79449209 |
| 98 | MP0001697_abnormal_embryo_size | 0.79391361 |
| 99 | MP0000749_muscle_degeneration | 0.78977511 |
| 100 | MP0003011_delayed_dark_adaptation | 0.78879301 |
| 101 | MP0002938_white_spotting | 0.78214007 |
| 102 | MP0000049_abnormal_middle_ear | 0.77865483 |
| 103 | MP0001970_abnormal_pain_threshold | 0.77194522 |
| 104 | MP0005332_abnormal_amino_acid | 0.77171029 |
| 105 | MP0009250_abnormal_appendicular_skeleto | 0.76499057 |
| 106 | MP0002272_abnormal_nervous_system | 0.75811873 |
| 107 | MP0003984_embryonic_growth_retardation | 0.75123801 |
| 108 | MP0001542_abnormal_bone_strength | 0.75119992 |
| 109 | MP0009745_abnormal_behavioral_response | 0.74902196 |
| 110 | MP0004133_heterotaxia | 0.74549355 |
| 111 | MP0008872_abnormal_physiological_respon | 0.74051942 |
| 112 | MP0000358_abnormal_cell_content/ | 0.73364082 |
| 113 | MP0001919_abnormal_reproductive_system | 0.72380441 |
| 114 | MP0005379_endocrine/exocrine_gland_phen | 0.71839205 |
| 115 | MP0002088_abnormal_embryonic_growth/wei | 0.71617815 |
| 116 | MP0002282_abnormal_trachea_morphology | 0.71207838 |
| 117 | MP0003119_abnormal_digestive_system | 0.70717335 |
| 118 | MP0002572_abnormal_emotion/affect_behav | 0.69145696 |
| 119 | MP0005380_embryogenesis_phenotype | 0.68773061 |
| 120 | MP0001672_abnormal_embryogenesis/_devel | 0.68773061 |
| 121 | MP0003787_abnormal_imprinting | 0.68599145 |
| 122 | MP0000750_abnormal_muscle_regeneration | 0.68289772 |
| 123 | MP0005253_abnormal_eye_physiology | 0.68264046 |
| 124 | MP0000026_abnormal_inner_ear | 0.68225026 |
| 125 | MP0004270_analgesia | 0.67868319 |
| 126 | MP0002080_prenatal_lethality | 0.67406478 |
| 127 | MP0000631_abnormal_neuroendocrine_gland | 0.67147705 |
| 128 | MP0003890_abnormal_embryonic-extraembry | 0.66997943 |
| 129 | MP0004924_abnormal_behavior | 0.66578928 |
| 130 | MP0005386_behavior/neurological_phenoty | 0.66578928 |
| 131 | MP0001270_distended_abdomen | 0.64413457 |
| 132 | MP0009672_abnormal_birth_weight | 0.64140269 |
| 133 | MP0003137_abnormal_impulse_conducting | 0.63774330 |
| 134 | MP0001286_abnormal_eye_development | 0.63314863 |
| 135 | MP0002019_abnormal_tumor_incidence | 0.62738462 |
| 136 | MP0002111_abnormal_tail_morphology | 0.62062966 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.16531374 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.56168530 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.44480822 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.37443802 |
| 5 | Increased serum pyruvate (HP:0003542) | 4.12252877 |
| 6 | Abnormality of glycolysis (HP:0004366) | 4.12252877 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.05241606 |
| 8 | Increased CSF lactate (HP:0002490) | 3.87396442 |
| 9 | Acute encephalopathy (HP:0006846) | 3.80906445 |
| 10 | Cerebral hypomyelination (HP:0006808) | 3.79970929 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.65639871 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.48759380 |
| 13 | Increased muscle lipid content (HP:0009058) | 3.34933715 |
| 14 | Breast hypoplasia (HP:0003187) | 3.18221719 |
| 15 | Congenital malformation of the right heart (HP:0011723) | 3.12936007 |
| 16 | Double outlet right ventricle (HP:0001719) | 3.12936007 |
| 17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.12557505 |
| 18 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.01387504 |
| 19 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.99452236 |
| 20 | Abnormal protein glycosylation (HP:0012346) | 2.96512473 |
| 21 | Abnormal glycosylation (HP:0012345) | 2.96512473 |
| 22 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.96512473 |
| 23 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.96512473 |
| 24 | Hepatic necrosis (HP:0002605) | 2.93330556 |
| 25 | Colon cancer (HP:0003003) | 2.91722589 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.91685226 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.91685226 |
| 28 | Increased serum lactate (HP:0002151) | 2.90468128 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.86803078 |
| 30 | Lipid accumulation in hepatocytes (HP:0006561) | 2.86787771 |
| 31 | Exercise intolerance (HP:0003546) | 2.86407414 |
| 32 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.79014799 |
| 33 | Exertional dyspnea (HP:0002875) | 2.76912619 |
| 34 | 3-Methylglutaconic aciduria (HP:0003535) | 2.73461399 |
| 35 | Carpal bone hypoplasia (HP:0001498) | 2.70917672 |
| 36 | Rough bone trabeculation (HP:0100670) | 2.70130622 |
| 37 | Irregular epiphyses (HP:0010582) | 2.66155169 |
| 38 | Abnormal number of erythroid precursors (HP:0012131) | 2.66109592 |
| 39 | Abnormal hair whorl (HP:0010721) | 2.62130815 |
| 40 | Respiratory difficulties (HP:0002880) | 2.60869293 |
| 41 | Leukodystrophy (HP:0002415) | 2.60725540 |
| 42 | Abnormality of the labia minora (HP:0012880) | 2.58971239 |
| 43 | Abnormality of the anterior horn cell (HP:0006802) | 2.55755427 |
| 44 | Degeneration of anterior horn cells (HP:0002398) | 2.55755427 |
| 45 | Patellar aplasia (HP:0006443) | 2.52826803 |
| 46 | Progressive microcephaly (HP:0000253) | 2.51356021 |
| 47 | Optic disc pallor (HP:0000543) | 2.50929897 |
| 48 | Respiratory failure (HP:0002878) | 2.50561660 |
| 49 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.47092442 |
| 50 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.40665772 |
| 51 | Lethargy (HP:0001254) | 2.40490571 |
| 52 | Poor head control (HP:0002421) | 2.39319108 |
| 53 | Lactic acidosis (HP:0003128) | 2.33009266 |
| 54 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.32775420 |
| 55 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.32775420 |
| 56 | Ragged-red muscle fibers (HP:0003200) | 2.31725199 |
| 57 | Poor suck (HP:0002033) | 2.29768400 |
| 58 | Sclerocornea (HP:0000647) | 2.27340786 |
| 59 | Absent epiphyses (HP:0010577) | 2.20165078 |
| 60 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 2.20165078 |
| 61 | Secondary amenorrhea (HP:0000869) | 2.17834688 |
| 62 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.17086865 |
| 63 | Dicarboxylic aciduria (HP:0003215) | 2.17086865 |
| 64 | CNS hypomyelination (HP:0003429) | 2.14648083 |
| 65 | Hypoplastic left heart (HP:0004383) | 2.14561370 |
| 66 | Methylmalonic aciduria (HP:0012120) | 2.13272701 |
| 67 | Delusions (HP:0000746) | 2.13248163 |
| 68 | Pancreatic fibrosis (HP:0100732) | 2.13099272 |
| 69 | Abnormal trabecular bone morphology (HP:0100671) | 2.11961506 |
| 70 | Medial flaring of the eyebrow (HP:0010747) | 2.10942073 |
| 71 | Cleft eyelid (HP:0000625) | 2.10934340 |
| 72 | Oral leukoplakia (HP:0002745) | 2.09082955 |
| 73 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.07444326 |
| 74 | Absent/shortened dynein arms (HP:0200106) | 2.07444326 |
| 75 | Cerebral edema (HP:0002181) | 2.07394913 |
| 76 | Unilateral renal agenesis (HP:0000122) | 2.06458176 |
| 77 | Pancytopenia (HP:0001876) | 2.06187841 |
| 78 | Patent foramen ovale (HP:0001655) | 2.04677682 |
| 79 | Premature graying of hair (HP:0002216) | 2.04099662 |
| 80 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.03951020 |
| 81 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.03564075 |
| 82 | Testicular atrophy (HP:0000029) | 2.02875744 |
| 83 | Macrocytic anemia (HP:0001972) | 2.02647037 |
| 84 | Abnormality of the preputium (HP:0100587) | 2.01137190 |
| 85 | Emotional lability (HP:0000712) | 2.00854019 |
| 86 | Meckel diverticulum (HP:0002245) | 2.00482523 |
| 87 | Unsteady gait (HP:0002317) | 1.99882197 |
| 88 | Abnormality of the parathyroid morphology (HP:0011766) | 1.99842261 |
| 89 | Microvesicular hepatic steatosis (HP:0001414) | 1.99520131 |
| 90 | Increased intramyocellular lipid droplets (HP:0012240) | 1.99167174 |
| 91 | Microretrognathia (HP:0000308) | 1.98613949 |
| 92 | CNS demyelination (HP:0007305) | 1.97116685 |
| 93 | Reticulocytopenia (HP:0001896) | 1.94616723 |
| 94 | Cholecystitis (HP:0001082) | 1.94065428 |
| 95 | Abnormal gallbladder physiology (HP:0012438) | 1.94065428 |
| 96 | X-linked dominant inheritance (HP:0001423) | 1.93428755 |
| 97 | Glycosuria (HP:0003076) | 1.92849709 |
| 98 | Abnormality of urine glucose concentration (HP:0011016) | 1.92849709 |
| 99 | Pancreatic cysts (HP:0001737) | 1.92805824 |
| 100 | Adrenal hypoplasia (HP:0000835) | 1.92304336 |
| 101 | Aplastic anemia (HP:0001915) | 1.91901126 |
| 102 | True hermaphroditism (HP:0010459) | 1.91816017 |
| 103 | Neoplasm of the adrenal gland (HP:0100631) | 1.91245930 |
| 104 | Abnormality of the ileum (HP:0001549) | 1.91220087 |
| 105 | Reduced antithrombin III activity (HP:0001976) | 1.90746237 |
| 106 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.90277060 |
| 107 | Rhinitis (HP:0012384) | 1.90074728 |
| 108 | Postnatal microcephaly (HP:0005484) | 1.89770271 |
| 109 | Facial cleft (HP:0002006) | 1.88958226 |
| 110 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.88441544 |
| 111 | Gait imbalance (HP:0002141) | 1.85162685 |
| 112 | Hypoplastic heart (HP:0001961) | 1.83950920 |
| 113 | Abnormal lung lobation (HP:0002101) | 1.83476608 |
| 114 | Methylmalonic acidemia (HP:0002912) | 1.82702026 |
| 115 | Parakeratosis (HP:0001036) | 1.80653921 |
| 116 | Type I transferrin isoform profile (HP:0003642) | 1.78351608 |
| 117 | Opisthotonus (HP:0002179) | 1.77883050 |
| 118 | Congenital primary aphakia (HP:0007707) | 1.77517281 |
| 119 | Abnormality of renal resorption (HP:0011038) | 1.77169421 |
| 120 | Abnormality of the aortic arch (HP:0012303) | 1.77115229 |
| 121 | Glossoptosis (HP:0000162) | 1.76635510 |
| 122 | Bone marrow hypocellularity (HP:0005528) | 1.76060807 |
| 123 | Generalized aminoaciduria (HP:0002909) | 1.75990908 |
| 124 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.74692343 |
| 125 | Pallor (HP:0000980) | 1.73809680 |
| 126 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.73706506 |
| 127 | Gliosis (HP:0002171) | 1.72948077 |
| 128 | Nephrogenic diabetes insipidus (HP:0009806) | 1.72433990 |
| 129 | Triphalangeal thumb (HP:0001199) | 1.72295482 |
| 130 | Abnormality of methionine metabolism (HP:0010901) | 1.72211011 |
| 131 | Cellular immunodeficiency (HP:0005374) | 1.71306351 |
| 132 | Hypoplasia of the uterus (HP:0000013) | 1.71301985 |
| 133 | Impulsivity (HP:0100710) | 1.70834722 |
| 134 | Broad distal phalanx of finger (HP:0009836) | 1.70480060 |
| 135 | Abnormality of alanine metabolism (HP:0010916) | 1.69889281 |
| 136 | Hyperalaninemia (HP:0003348) | 1.69889281 |
| 137 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.69889281 |
| 138 | Truncus arteriosus (HP:0001660) | 1.69584283 |
| 139 | Hyperglycinemia (HP:0002154) | 1.69417620 |
| 140 | Absent radius (HP:0003974) | 1.68663135 |
| 141 | Muscle fiber atrophy (HP:0100295) | 1.68089757 |
| 142 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.67715372 |
| 143 | Single umbilical artery (HP:0001195) | 1.67715372 |
| 144 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.67715372 |
| 145 | Horseshoe kidney (HP:0000085) | 1.65644507 |
| 146 | Blindness (HP:0000618) | 1.63061983 |
| 147 | Redundant skin (HP:0001582) | 1.58902140 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 7.19890170 |
| 2 | BUB1 | 4.57015389 |
| 3 | TAF1 | 3.49180446 |
| 4 | SMG1 | 3.19079086 |
| 5 | EIF2AK1 | 3.06266545 |
| 6 | STK16 | 2.97189260 |
| 7 | NUAK1 | 2.59653320 |
| 8 | WEE1 | 2.57967019 |
| 9 | BCKDK | 2.51297639 |
| 10 | EIF2AK3 | 2.46381803 |
| 11 | NME2 | 2.40699389 |
| 12 | NME1 | 2.26420489 |
| 13 | PLK4 | 2.25246540 |
| 14 | CASK | 2.23030444 |
| 15 | TSSK6 | 2.19805614 |
| 16 | VRK1 | 2.13261656 |
| 17 | SRPK1 | 2.04324321 |
| 18 | PBK | 2.04043442 |
| 19 | CCNB1 | 1.98555821 |
| 20 | MAP2K7 | 1.96297488 |
| 21 | MAP3K12 | 1.95417633 |
| 22 | ARAF | 1.83507708 |
| 23 | TESK1 | 1.83443320 |
| 24 | DYRK2 | 1.75096757 |
| 25 | PIM2 | 1.70784796 |
| 26 | LIMK1 | 1.69738675 |
| 27 | BRAF | 1.64084298 |
| 28 | PLK3 | 1.62809799 |
| 29 | BCR | 1.60034568 |
| 30 | PDK3 | 1.55427523 |
| 31 | PDK4 | 1.55427523 |
| 32 | BRSK2 | 1.50054820 |
| 33 | AKT3 | 1.49154797 |
| 34 | CSNK1A1L | 1.47018091 |
| 35 | BMPR1B | 1.45660559 |
| 36 | PNCK | 1.41967661 |
| 37 | MST4 | 1.41201888 |
| 38 | CSNK1G1 | 1.39503785 |
| 39 | MAP4K2 | 1.38437566 |
| 40 | PLK2 | 1.33745341 |
| 41 | MAP3K4 | 1.32259018 |
| 42 | CDC7 | 1.31110466 |
| 43 | BRSK1 | 1.30946446 |
| 44 | STK38L | 1.30094648 |
| 45 | CSNK1G2 | 1.25284567 |
| 46 | PLK1 | 1.23077249 |
| 47 | NEK1 | 1.22291183 |
| 48 | ZAK | 1.22041482 |
| 49 | SIK3 | 1.21957108 |
| 50 | MARK1 | 1.21631896 |
| 51 | TLK1 | 1.19942238 |
| 52 | MAPKAPK5 | 1.16533464 |
| 53 | MKNK1 | 1.14437406 |
| 54 | TRIM28 | 1.12235696 |
| 55 | AURKA | 1.11546016 |
| 56 | PRKD3 | 1.06277636 |
| 57 | TESK2 | 1.06027903 |
| 58 | CDK8 | 1.00083179 |
| 59 | PDK2 | 0.98579072 |
| 60 | MYLK | 0.98233686 |
| 61 | EIF2AK2 | 0.97931869 |
| 62 | TTK | 0.94875519 |
| 63 | MAPK13 | 0.90873460 |
| 64 | GRK5 | 0.86917757 |
| 65 | BMPR2 | 0.81550140 |
| 66 | PAK1 | 0.81472899 |
| 67 | NEK2 | 0.81397915 |
| 68 | ACVR1B | 0.80382430 |
| 69 | PASK | 0.78816847 |
| 70 | CDK9 | 0.78448521 |
| 71 | GRK7 | 0.75756815 |
| 72 | MUSK | 0.74346835 |
| 73 | CDK19 | 0.72660852 |
| 74 | MINK1 | 0.71957250 |
| 75 | KDR | 0.71767901 |
| 76 | CDK3 | 0.71294142 |
| 77 | AURKB | 0.69900077 |
| 78 | MKNK2 | 0.68994420 |
| 79 | STK24 | 0.67007196 |
| 80 | ABL2 | 0.66792996 |
| 81 | TAOK2 | 0.64836602 |
| 82 | CHEK2 | 0.63087901 |
| 83 | ADRBK2 | 0.62473686 |
| 84 | CSNK2A1 | 0.61155828 |
| 85 | DAPK1 | 0.61004678 |
| 86 | YES1 | 0.59043004 |
| 87 | DAPK3 | 0.57604582 |
| 88 | WNK3 | 0.56984394 |
| 89 | CDK18 | 0.56710795 |
| 90 | STK4 | 0.56510549 |
| 91 | ATR | 0.54107384 |
| 92 | ERBB3 | 0.53394291 |
| 93 | CDK14 | 0.53111749 |
| 94 | ILK | 0.52681816 |
| 95 | LATS2 | 0.52308369 |
| 96 | ATM | 0.48164449 |
| 97 | OBSCN | 0.46683272 |
| 98 | CDK15 | 0.46073615 |
| 99 | CSNK1G3 | 0.46014030 |
| 100 | CSNK2A2 | 0.45096117 |
| 101 | CHEK1 | 0.44398228 |
| 102 | CDK11A | 0.42605468 |
| 103 | IRAK3 | 0.42133048 |
| 104 | TIE1 | 0.42006222 |
| 105 | PRKCI | 0.41705849 |
| 106 | AKT2 | 0.41390690 |
| 107 | ALK | 0.40409414 |
| 108 | CDK4 | 0.40048929 |
| 109 | FLT3 | 0.39691916 |
| 110 | MAP3K11 | 0.39064950 |
| 111 | RPS6KA4 | 0.37738718 |
| 112 | DYRK3 | 0.37245043 |
| 113 | PRKCG | 0.37116812 |
| 114 | UHMK1 | 0.35317142 |
| 115 | CDK7 | 0.35018959 |
| 116 | CAMK2B | 0.34690504 |
| 117 | MAP2K4 | 0.34028128 |
| 118 | MELK | 0.34027397 |
| 119 | PTK2B | 0.33583606 |
| 120 | RPS6KA5 | 0.33467087 |
| 121 | ADRBK1 | 0.31340728 |
| 122 | MAP2K6 | 0.30877063 |
| 123 | CDK2 | 0.30147703 |
| 124 | EPHA2 | 0.29612601 |
| 125 | PRPF4B | 0.28988038 |
| 126 | PAK4 | 0.28522265 |
| 127 | LRRK2 | 0.28462900 |
| 128 | CDK1 | 0.28441042 |
| 129 | GRK1 | 0.27996300 |
| 130 | RPS6KB2 | 0.27764088 |
| 131 | MAP3K8 | 0.27577243 |
| 132 | CSNK1A1 | 0.27385860 |
| 133 | MAPK11 | 0.24232883 |
| 134 | CLK1 | 0.22433168 |
| 135 | TGFBR1 | 0.22166335 |
| 136 | CSNK1E | 0.20634074 |
| 137 | ERBB4 | 0.17638841 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.49479412 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 4.08122441 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.58044914 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.46611122 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.11479697 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.04470564 |
| 7 | Sulfur relay system_Homo sapiens_hsa04122 | 2.94301847 |
| 8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.65287584 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.63833604 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.47503096 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.44807046 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.42195898 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 2.37316950 |
| 14 | Mismatch repair_Homo sapiens_hsa03430 | 2.32029081 |
| 15 | Protein export_Homo sapiens_hsa03060 | 2.07641542 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 2.04976947 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 2.02653958 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.00266489 |
| 19 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.80549954 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.72641908 |
| 21 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.71984762 |
| 22 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.66608417 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.61494547 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.61068284 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.60335794 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.59506115 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.55074588 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.46003300 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.42579899 |
| 30 | RNA degradation_Homo sapiens_hsa03018 | 1.38215420 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.32367699 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.29006653 |
| 33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.22972173 |
| 34 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.17564833 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.16612224 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.10778220 |
| 37 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.04403894 |
| 38 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.03583978 |
| 39 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.01899821 |
| 40 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.99018648 |
| 41 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.98854632 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.98062632 |
| 43 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.91296244 |
| 44 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.90814097 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.87399417 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81814102 |
| 47 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.81060017 |
| 48 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.79999228 |
| 49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79025260 |
| 50 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.79024134 |
| 51 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.77882128 |
| 52 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.77671256 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.76867282 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.75629721 |
| 55 | Allograft rejection_Homo sapiens_hsa05330 | 0.75468597 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.74561657 |
| 57 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.73674627 |
| 58 | Peroxisome_Homo sapiens_hsa04146 | 0.71776527 |
| 59 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.70911848 |
| 60 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.69966443 |
| 61 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.67699067 |
| 62 | Legionellosis_Homo sapiens_hsa05134 | 0.67504441 |
| 63 | Phagosome_Homo sapiens_hsa04145 | 0.66914270 |
| 64 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.64798755 |
| 65 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.63857270 |
| 66 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.59201743 |
| 67 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.56059399 |
| 68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.55562542 |
| 69 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.53864542 |
| 70 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.53764733 |
| 71 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.53437323 |
| 72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.50706565 |
| 73 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.49945280 |
| 74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49370696 |
| 75 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.49308750 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.49034193 |
| 77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.48693470 |
| 78 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.48359787 |
| 79 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.46140215 |
| 80 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.45344104 |
| 81 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.44900788 |
| 82 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.43494385 |
| 83 | Asthma_Homo sapiens_hsa05310 | 0.39604269 |
| 84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.39551747 |
| 85 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.39332630 |
| 86 | Shigellosis_Homo sapiens_hsa05131 | 0.38939567 |
| 87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.36193845 |
| 88 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35758920 |
| 89 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.35488092 |
| 90 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.34689413 |
| 91 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34381401 |
| 92 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.34109074 |
| 93 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.33282051 |
| 94 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.32872466 |
| 95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.30868117 |
| 96 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.29797166 |
| 97 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.28493600 |
| 98 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.28486887 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.28062630 |
| 100 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.25859173 |
| 101 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.23286924 |
| 102 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.23026751 |
| 103 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21865167 |
| 104 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.20164560 |
| 105 | Carbon metabolism_Homo sapiens_hsa01200 | 0.20020185 |
| 106 | Phototransduction_Homo sapiens_hsa04744 | 0.18871809 |
| 107 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.18276253 |
| 108 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17856398 |
| 109 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.17242795 |
| 110 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.17054253 |
| 111 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.16874491 |
| 112 | Salmonella infection_Homo sapiens_hsa05132 | 0.15896184 |
| 113 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.15625436 |
| 114 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.15000111 |
| 115 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.14974458 |
| 116 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.13349593 |
| 117 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.12677036 |
| 118 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.11975834 |
| 119 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.11024151 |
| 120 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.10761154 |
| 121 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.10216236 |
| 122 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.09974849 |
| 123 | Galactose metabolism_Homo sapiens_hsa00052 | 0.09918611 |
| 124 | Influenza A_Homo sapiens_hsa05164 | 0.09757676 |
| 125 | HTLV-I infection_Homo sapiens_hsa05166 | 0.09317505 |
| 126 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.08298483 |
| 127 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.08287126 |
| 128 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.07811744 |
| 129 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.07343335 |
| 130 | Apoptosis_Homo sapiens_hsa04210 | 0.07206676 |
| 131 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.06438731 |
| 132 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.05533675 |
| 133 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.04147829 |
| 134 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.03589543 |
| 135 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.02135129 |

