ELP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.14047764
2proteasome assembly (GO:0043248)5.05147090
3protein deneddylation (GO:0000338)4.85422008
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.76156517
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.56158490
6oxidative phosphorylation (GO:0006119)4.55198851
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51030704
87-methylguanosine mRNA capping (GO:0006370)4.47915567
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.44356662
10RNA capping (GO:0036260)4.38611703
117-methylguanosine RNA capping (GO:0009452)4.38611703
12anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.38602403
13negative regulation of ligase activity (GO:0051352)4.38299238
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.38299238
15ATP synthesis coupled proton transport (GO:0015986)4.35705385
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35705385
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.35162914
18protein neddylation (GO:0045116)4.33051530
19chaperone-mediated protein transport (GO:0072321)4.32314780
20regulation of cellular amino acid metabolic process (GO:0006521)4.30962466
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.24034128
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.24034128
23termination of RNA polymerase III transcription (GO:0006386)4.23755697
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.23755697
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.22566019
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.22566019
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.22566019
28signal transduction involved in DNA integrity checkpoint (GO:0072401)4.11388056
29signal transduction involved in DNA damage checkpoint (GO:0072422)4.11388056
30signal transduction involved in cell cycle checkpoint (GO:0072395)4.08583793
31positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.01920978
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.86835566
33positive regulation of ligase activity (GO:0051351)3.83140711
34pseudouridine synthesis (GO:0001522)3.73880653
35formation of translation preinitiation complex (GO:0001731)3.71954930
36DNA strand elongation involved in DNA replication (GO:0006271)3.69629007
37DNA damage response, detection of DNA damage (GO:0042769)3.63810370
38kinetochore assembly (GO:0051382)3.61250526
39antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.60766138
40rRNA modification (GO:0000154)3.60313547
41telomere maintenance via semi-conservative replication (GO:0032201)3.58993871
42respiratory chain complex IV assembly (GO:0008535)3.58021511
43regulation of ubiquitin-protein transferase activity (GO:0051438)3.57225213
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.55793296
45DNA strand elongation (GO:0022616)3.55494005
46spliceosomal snRNP assembly (GO:0000387)3.54739195
47cytochrome complex assembly (GO:0017004)3.52182492
48DNA deamination (GO:0045006)3.51942448
49ribosomal large subunit biogenesis (GO:0042273)3.49215540
50protein targeting to mitochondrion (GO:0006626)3.46508375
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46135390
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46135390
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44572686
54regulation of ligase activity (GO:0051340)3.43387993
55maturation of SSU-rRNA (GO:0030490)3.43220524
56DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.43203754
57peptidyl-arginine omega-N-methylation (GO:0035247)3.41582224
58establishment of protein localization to mitochondrion (GO:0072655)3.41256840
59histone arginine methylation (GO:0034969)3.40472187
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40142484
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38060790
62guanosine-containing compound biosynthetic process (GO:1901070)3.37647750
63kinetochore organization (GO:0051383)3.36913346
64positive regulation of cell cycle arrest (GO:0071158)3.34775242
65purine nucleobase biosynthetic process (GO:0009113)3.32714937
66chromatin remodeling at centromere (GO:0031055)3.32513724
67mitotic metaphase plate congression (GO:0007080)3.31921725
68metallo-sulfur cluster assembly (GO:0031163)3.29556777
69iron-sulfur cluster assembly (GO:0016226)3.29556777
70protein complex biogenesis (GO:0070271)3.28721698
71viral transcription (GO:0019083)3.28542522
72transcription elongation from RNA polymerase II promoter (GO:0006368)3.28244668
73ATP biosynthetic process (GO:0006754)3.26964673
74microtubule depolymerization (GO:0007019)3.26386148
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.25713852
76GTP biosynthetic process (GO:0006183)3.25074186
77protein K6-linked ubiquitination (GO:0085020)3.25051541
78ribosomal small subunit assembly (GO:0000028)3.24364511
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24182290
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.23655219
81NADH dehydrogenase complex assembly (GO:0010257)3.23655219
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23655219
83purine nucleoside triphosphate biosynthetic process (GO:0009145)3.23572197
84transcription elongation from RNA polymerase I promoter (GO:0006362)3.23462900
85regulation of mitochondrial translation (GO:0070129)3.22677385
86regulation of cellular amine metabolic process (GO:0033238)3.22350510
87protein localization to mitochondrion (GO:0070585)3.21534799
88transcription-coupled nucleotide-excision repair (GO:0006283)3.20154410
89translational termination (GO:0006415)3.17940392
90nucleobase biosynthetic process (GO:0046112)3.16243746
91ribonucleoprotein complex biogenesis (GO:0022613)3.15909984
92ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15583207
93ribosome biogenesis (GO:0042254)3.15159746
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14948925
95base-excision repair (GO:0006284)3.14644819
96mitochondrial RNA metabolic process (GO:0000959)3.13054612
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12074921
98de novo protein folding (GO:0006458)3.10326774
99transcription from RNA polymerase I promoter (GO:0006360)3.09836853
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09044788
101termination of RNA polymerase I transcription (GO:0006363)3.08819497
102de novo posttranslational protein folding (GO:0051084)3.07674817
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07562126
104DNA-templated transcription, elongation (GO:0006354)3.07077183
105cotranslational protein targeting to membrane (GO:0006613)3.06862440
106inner mitochondrial membrane organization (GO:0007007)3.06070134
107mitochondrial respiratory chain complex assembly (GO:0033108)3.06004671
108positive regulation of viral transcription (GO:0050434)3.03160433
109cell cycle G1/S phase transition (GO:0044843)3.03084364
110G1/S transition of mitotic cell cycle (GO:0000082)3.03084364
111establishment of viral latency (GO:0019043)3.03017007
112respiratory electron transport chain (GO:0022904)3.01423984
113protein targeting to ER (GO:0045047)3.01055289
114translational elongation (GO:0006414)3.01045193
115CTP metabolic process (GO:0046036)3.00907151
116CTP biosynthetic process (GO:0006241)3.00907151
117rRNA processing (GO:0006364)3.00637674
118translation (GO:0006412)3.00123127
119blastocyst development (GO:0001824)2.99930151
120cellular component biogenesis (GO:0044085)2.99681623
121CENP-A containing nucleosome assembly (GO:0034080)2.99267631
122signal transduction in response to DNA damage (GO:0042770)2.98756062
123DNA replication checkpoint (GO:0000076)2.98524087
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98071795
125regulation of helicase activity (GO:0051095)2.97459316
126ribosome assembly (GO:0042255)2.96944613
127ribosomal small subunit biogenesis (GO:0042274)2.96540741
128negative regulation of protein ubiquitination (GO:0031397)2.96304290
129electron transport chain (GO:0022900)2.96251012
130peptidyl-histidine modification (GO:0018202)2.95838241
131negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.95441933
132negative regulation of cell cycle G1/S phase transition (GO:1902807)2.95441933
133establishment of integrated proviral latency (GO:0075713)2.94912260
134rRNA metabolic process (GO:0016072)2.90988090
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90338443
136deoxyribose phosphate biosynthetic process (GO:0046385)2.90304023
1372-deoxyribonucleotide biosynthetic process (GO:0009265)2.90304023
138UTP biosynthetic process (GO:0006228)2.89664656
139deoxyribonucleotide biosynthetic process (GO:0009263)2.89430831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92143369
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.40873692
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.18842904
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.17277464
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.86739887
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.72756567
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.69861565
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.63651203
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61444048
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18397674
11E2F7_22180533_ChIP-Seq_HELA_Human3.16837258
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15719538
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06311157
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02951002
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02373195
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93788359
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90089961
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68695890
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63598777
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63180608
21VDR_23849224_ChIP-Seq_CD4+_Human2.53213212
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.52779228
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.35186515
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.29408577
25DCP1A_22483619_ChIP-Seq_HELA_Human2.28659782
26XRN2_22483619_ChIP-Seq_HELA_Human2.25205079
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19017617
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15406820
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14090369
30GABP_19822575_ChIP-Seq_HepG2_Human2.10488161
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09521953
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05251716
33FOXP3_21729870_ChIP-Seq_TREG_Human2.03855219
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96379058
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96241298
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95846673
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93851702
38ELK1_19687146_ChIP-ChIP_HELA_Human1.91209808
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88445354
40TTF2_22483619_ChIP-Seq_HELA_Human1.86493865
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81955340
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79775959
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75722432
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73211793
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72172289
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67105987
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65934580
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53630412
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53455057
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.47846865
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41394349
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40819982
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32830989
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29189552
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27874653
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26967992
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26678329
58MYC_18940864_ChIP-ChIP_HL60_Human1.22750598
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21175508
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18593501
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18139823
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.17739754
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17556726
64FOXP1_21924763_ChIP-Seq_HESCs_Human1.13089836
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11234083
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10617667
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10089719
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06549018
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06394715
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06380973
71AR_21909140_ChIP-Seq_LNCAP_Human1.04316701
72CIITA_25753668_ChIP-Seq_RAJI_Human1.03342960
73KDM5A_27292631_Chip-Seq_BREAST_Human1.02668888
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.01929184
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97931708
76TP63_19390658_ChIP-ChIP_HaCaT_Human0.95718734
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95359722
78TET1_21451524_ChIP-Seq_MESCs_Mouse0.94137221
79CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93148426
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92975877
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92888777
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91847676
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91759724
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91742257
85VDR_22108803_ChIP-Seq_LS180_Human0.91621532
86SOX17_20123909_ChIP-Seq_XEN_Mouse0.90482355
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90211477
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89872834
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89664138
90ZNF274_21170338_ChIP-Seq_K562_Hela0.89122612
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88933384
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88515025
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87722672
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82821171
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82288248
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81923579
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81895500
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80969873
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80753641
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79985672
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78944553
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78212479
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77246091
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76869497
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.76136627
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75713236
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74647906
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74048636
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72531963
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71882612
111YY1_22570637_ChIP-Seq_MALME-3M_Human0.71221503
112TFEB_21752829_ChIP-Seq_HELA_Human0.70117972
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69789996
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.68542842
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68450380
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.68243096
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67861503
118IRF1_19129219_ChIP-ChIP_H3396_Human0.67516320
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67480901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.69121236
2MP0002234_abnormal_pharynx_morphology3.38342620
3MP0001529_abnormal_vocalization3.25396501
4MP0004957_abnormal_blastocyst_morpholog3.04188227
5MP0008058_abnormal_DNA_repair2.82385020
6MP0008057_abnormal_DNA_replication2.78186464
7MP0008877_abnormal_DNA_methylation2.74857511
8MP0003077_abnormal_cell_cycle2.65967580
9MP0003111_abnormal_nucleus_morphology2.57301681
10MP0010094_abnormal_chromosome_stability2.49973869
11MP0008932_abnormal_embryonic_tissue2.45317491
12MP0003123_paternal_imprinting2.36983728
13MP0003880_abnormal_central_pattern2.34560438
14MP0005410_abnormal_fertilization2.33516371
15MP0003718_maternal_effect2.26635216
16MP0006292_abnormal_olfactory_placode2.08796007
17MP0001905_abnormal_dopamine_level2.07357478
18MP0008007_abnormal_cellular_replicative1.97000449
19MP0002736_abnormal_nociception_after1.96144830
20MP0002163_abnormal_gland_morphology1.95299160
21MP0002653_abnormal_ependyma_morphology1.93689147
22MP0002638_abnormal_pupillary_reflex1.92765101
23MP0008260_abnormal_autophagy1.89843022
24MP0002102_abnormal_ear_morphology1.89006042
25MP0003646_muscle_fatigue1.83496840
26MP0002822_catalepsy1.81858967
27MP0010386_abnormal_urinary_bladder1.80976055
28MP0003122_maternal_imprinting1.78943194
29MP0009379_abnormal_foot_pigmentation1.76922277
30MP0006276_abnormal_autonomic_nervous1.72367918
31MP0003786_premature_aging1.68087598
32MP0001188_hyperpigmentation1.62277002
33MP0001968_abnormal_touch/_nociception1.61932084
34MP0001764_abnormal_homeostasis1.61723876
35MP0003121_genomic_imprinting1.55287443
36MP0008995_early_reproductive_senescence1.52390912
37MP0002210_abnormal_sex_determination1.45482231
38MP0002249_abnormal_larynx_morphology1.44156320
39MP0001346_abnormal_lacrimal_gland1.41521725
40MP0001929_abnormal_gametogenesis1.38404517
41MP0003315_abnormal_perineum_morphology1.35965389
42MP0002160_abnormal_reproductive_system1.33958384
43MP0006072_abnormal_retinal_apoptosis1.33409523
44MP0001293_anophthalmia1.31941068
45MP0009697_abnormal_copulation1.30971819
46MP0001730_embryonic_growth_arrest1.29820995
47MP0003698_abnormal_male_reproductive1.29767835
48MP0000678_abnormal_parathyroid_gland1.29698201
49MP0008789_abnormal_olfactory_epithelium1.29539752
50MP0009333_abnormal_splenocyte_physiolog1.29010018
51MP0003136_yellow_coat_color1.27928187
52MP0002734_abnormal_mechanical_nocicepti1.24512832
53MP0002735_abnormal_chemical_nociception1.23198301
54MP0005645_abnormal_hypothalamus_physiol1.22566310
55MP0006035_abnormal_mitochondrial_morpho1.22549380
56MP0001986_abnormal_taste_sensitivity1.20744891
57MP0003186_abnormal_redox_activity1.17297664
58MP0000015_abnormal_ear_pigmentation1.17182567
59MP0000350_abnormal_cell_proliferation1.13952180
60MP0001145_abnormal_male_reproductive1.13514246
61MP0002751_abnormal_autonomic_nervous1.09532179
62MP0001727_abnormal_embryo_implantation1.08098539
63MP0006036_abnormal_mitochondrial_physio1.07411047
64MP0001984_abnormal_olfaction1.03392982
65MP0005389_reproductive_system_phenotype1.02748911
66MP0005499_abnormal_olfactory_system0.99869716
67MP0005394_taste/olfaction_phenotype0.99869716
68MP0003567_abnormal_fetal_cardiomyocyte0.99328459
69MP0003806_abnormal_nucleotide_metabolis0.99170204
70MP0003941_abnormal_skin_development0.99072657
71MP0000653_abnormal_sex_gland0.98515274
72MP0002233_abnormal_nose_morphology0.98040779
73MP0009046_muscle_twitch0.96726657
74MP0000372_irregular_coat_pigmentation0.96438617
75MP0003937_abnormal_limbs/digits/tail_de0.96201781
76MP0001661_extended_life_span0.95685999
77MP0000778_abnormal_nervous_system0.94273306
78MP0000566_synostosis0.92249415
79MP0002132_abnormal_respiratory_system0.91676210
80MP0004142_abnormal_muscle_tone0.91113733
81MP0002184_abnormal_innervation0.91034430
82MP0003221_abnormal_cardiomyocyte_apopto0.90092709
83MP0002085_abnormal_embryonic_tissue0.88682857
84MP0005330_cardiomyopathy0.88400291
85MP0002277_abnormal_respiratory_mucosa0.88057337
86MP0001440_abnormal_grooming_behavior0.85261420
87MP0003938_abnormal_ear_development0.84142702
88MP0005171_absent_coat_pigmentation0.83970452
89MP0002064_seizures0.83854966
90MP0000313_abnormal_cell_death0.83561487
91MP0002837_dystrophic_cardiac_calcinosis0.83069077
92MP0004147_increased_porphyrin_level0.82859761
93MP0005423_abnormal_somatic_nervous0.82168764
94MP0004742_abnormal_vestibular_system0.81997694
95MP0010030_abnormal_orbit_morphology0.81322785
96MP0002161_abnormal_fertility/fecundity0.80792480
97MP0005084_abnormal_gallbladder_morpholo0.79449209
98MP0001697_abnormal_embryo_size0.79391361
99MP0000749_muscle_degeneration0.78977511
100MP0003011_delayed_dark_adaptation0.78879301
101MP0002938_white_spotting0.78214007
102MP0000049_abnormal_middle_ear0.77865483
103MP0001970_abnormal_pain_threshold0.77194522
104MP0005332_abnormal_amino_acid0.77171029
105MP0009250_abnormal_appendicular_skeleto0.76499057
106MP0002272_abnormal_nervous_system0.75811873
107MP0003984_embryonic_growth_retardation0.75123801
108MP0001542_abnormal_bone_strength0.75119992
109MP0009745_abnormal_behavioral_response0.74902196
110MP0004133_heterotaxia0.74549355
111MP0008872_abnormal_physiological_respon0.74051942
112MP0000358_abnormal_cell_content/0.73364082
113MP0001919_abnormal_reproductive_system0.72380441
114MP0005379_endocrine/exocrine_gland_phen0.71839205
115MP0002088_abnormal_embryonic_growth/wei0.71617815
116MP0002282_abnormal_trachea_morphology0.71207838
117MP0003119_abnormal_digestive_system0.70717335
118MP0002572_abnormal_emotion/affect_behav0.69145696
119MP0005380_embryogenesis_phenotype0.68773061
120MP0001672_abnormal_embryogenesis/_devel0.68773061
121MP0003787_abnormal_imprinting0.68599145
122MP0000750_abnormal_muscle_regeneration0.68289772
123MP0005253_abnormal_eye_physiology0.68264046
124MP0000026_abnormal_inner_ear0.68225026
125MP0004270_analgesia0.67868319
126MP0002080_prenatal_lethality0.67406478
127MP0000631_abnormal_neuroendocrine_gland0.67147705
128MP0003890_abnormal_embryonic-extraembry0.66997943
129MP0005386_behavior/neurological_phenoty0.66578928
130MP0004924_abnormal_behavior0.66578928
131MP0001270_distended_abdomen0.64413457
132MP0009672_abnormal_birth_weight0.64140269
133MP0003137_abnormal_impulse_conducting0.63774330
134MP0001286_abnormal_eye_development0.63314863
135MP0002019_abnormal_tumor_incidence0.62738462
136MP0002111_abnormal_tail_morphology0.62062966

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.16531374
2Abnormal mitochondria in muscle tissue (HP:0008316)4.56168530
3Mitochondrial inheritance (HP:0001427)4.44480822
4Birth length less than 3rd percentile (HP:0003561)4.37443802
5Increased serum pyruvate (HP:0003542)4.12252877
6Abnormality of glycolysis (HP:0004366)4.12252877
7Progressive macrocephaly (HP:0004481)4.05241606
8Increased CSF lactate (HP:0002490)3.87396442
9Acute encephalopathy (HP:0006846)3.80906445
10Cerebral hypomyelination (HP:0006808)3.79970929
11Hepatocellular necrosis (HP:0001404)3.65639871
12Increased hepatocellular lipid droplets (HP:0006565)3.48759380
13Increased muscle lipid content (HP:0009058)3.34933715
14Breast hypoplasia (HP:0003187)3.18221719
15Congenital malformation of the right heart (HP:0011723)3.12936007
16Double outlet right ventricle (HP:0001719)3.12936007
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12557505
18Abnormality of cells of the erythroid lineage (HP:0012130)3.01387504
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.99452236
20Abnormal protein glycosylation (HP:0012346)2.96512473
21Abnormal glycosylation (HP:0012345)2.96512473
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.96512473
23Abnormal protein N-linked glycosylation (HP:0012347)2.96512473
24Hepatic necrosis (HP:0002605)2.93330556
25Colon cancer (HP:0003003)2.91722589
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91685226
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91685226
28Increased serum lactate (HP:0002151)2.90468128
29Renal Fanconi syndrome (HP:0001994)2.86803078
30Lipid accumulation in hepatocytes (HP:0006561)2.86787771
31Exercise intolerance (HP:0003546)2.86407414
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.79014799
33Exertional dyspnea (HP:0002875)2.76912619
343-Methylglutaconic aciduria (HP:0003535)2.73461399
35Carpal bone hypoplasia (HP:0001498)2.70917672
36Rough bone trabeculation (HP:0100670)2.70130622
37Irregular epiphyses (HP:0010582)2.66155169
38Abnormal number of erythroid precursors (HP:0012131)2.66109592
39Abnormal hair whorl (HP:0010721)2.62130815
40Respiratory difficulties (HP:0002880)2.60869293
41Leukodystrophy (HP:0002415)2.60725540
42Abnormality of the labia minora (HP:0012880)2.58971239
43Degeneration of anterior horn cells (HP:0002398)2.55755427
44Abnormality of the anterior horn cell (HP:0006802)2.55755427
45Patellar aplasia (HP:0006443)2.52826803
46Progressive microcephaly (HP:0000253)2.51356021
47Optic disc pallor (HP:0000543)2.50929897
48Respiratory failure (HP:0002878)2.50561660
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.47092442
50Aplasia/Hypoplasia of the patella (HP:0006498)2.40665772
51Lethargy (HP:0001254)2.40490571
52Poor head control (HP:0002421)2.39319108
53Lactic acidosis (HP:0003128)2.33009266
54Abnormal respiratory epithelium morphology (HP:0012253)2.32775420
55Abnormal respiratory motile cilium morphology (HP:0005938)2.32775420
56Ragged-red muscle fibers (HP:0003200)2.31725199
57Poor suck (HP:0002033)2.29768400
58Sclerocornea (HP:0000647)2.27340786
59Absent epiphyses (HP:0010577)2.20165078
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.20165078
61Secondary amenorrhea (HP:0000869)2.17834688
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17086865
63Dicarboxylic aciduria (HP:0003215)2.17086865
64CNS hypomyelination (HP:0003429)2.14648083
65Hypoplastic left heart (HP:0004383)2.14561370
66Methylmalonic aciduria (HP:0012120)2.13272701
67Delusions (HP:0000746)2.13248163
68Pancreatic fibrosis (HP:0100732)2.13099272
69Abnormal trabecular bone morphology (HP:0100671)2.11961506
70Medial flaring of the eyebrow (HP:0010747)2.10942073
71Cleft eyelid (HP:0000625)2.10934340
72Oral leukoplakia (HP:0002745)2.09082955
73Dynein arm defect of respiratory motile cilia (HP:0012255)2.07444326
74Absent/shortened dynein arms (HP:0200106)2.07444326
75Cerebral edema (HP:0002181)2.07394913
76Unilateral renal agenesis (HP:0000122)2.06458176
77Pancytopenia (HP:0001876)2.06187841
78Patent foramen ovale (HP:0001655)2.04677682
79Premature graying of hair (HP:0002216)2.04099662
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03951020
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03564075
82Testicular atrophy (HP:0000029)2.02875744
83Macrocytic anemia (HP:0001972)2.02647037
84Abnormality of the preputium (HP:0100587)2.01137190
85Emotional lability (HP:0000712)2.00854019
86Meckel diverticulum (HP:0002245)2.00482523
87Unsteady gait (HP:0002317)1.99882197
88Abnormality of the parathyroid morphology (HP:0011766)1.99842261
89Microvesicular hepatic steatosis (HP:0001414)1.99520131
90Increased intramyocellular lipid droplets (HP:0012240)1.99167174
91Microretrognathia (HP:0000308)1.98613949
92CNS demyelination (HP:0007305)1.97116685
93Reticulocytopenia (HP:0001896)1.94616723
94Cholecystitis (HP:0001082)1.94065428
95Abnormal gallbladder physiology (HP:0012438)1.94065428
96X-linked dominant inheritance (HP:0001423)1.93428755
97Glycosuria (HP:0003076)1.92849709
98Abnormality of urine glucose concentration (HP:0011016)1.92849709
99Pancreatic cysts (HP:0001737)1.92805824
100Adrenal hypoplasia (HP:0000835)1.92304336
101Aplastic anemia (HP:0001915)1.91901126
102True hermaphroditism (HP:0010459)1.91816017
103Neoplasm of the adrenal gland (HP:0100631)1.91245930
104Abnormality of the ileum (HP:0001549)1.91220087
105Reduced antithrombin III activity (HP:0001976)1.90746237
106Aplasia/hypoplasia of the uterus (HP:0008684)1.90277060
107Rhinitis (HP:0012384)1.90074728
108Postnatal microcephaly (HP:0005484)1.89770271
109Facial cleft (HP:0002006)1.88958226
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88441544
111Gait imbalance (HP:0002141)1.85162685
112Hypoplastic heart (HP:0001961)1.83950920
113Abnormal lung lobation (HP:0002101)1.83476608
114Methylmalonic acidemia (HP:0002912)1.82702026
115Parakeratosis (HP:0001036)1.80653921
116Type I transferrin isoform profile (HP:0003642)1.78351608
117Opisthotonus (HP:0002179)1.77883050
118Congenital primary aphakia (HP:0007707)1.77517281
119Abnormality of renal resorption (HP:0011038)1.77169421
120Abnormality of the aortic arch (HP:0012303)1.77115229
121Glossoptosis (HP:0000162)1.76635510
122Bone marrow hypocellularity (HP:0005528)1.76060807
123Generalized aminoaciduria (HP:0002909)1.75990908
124Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74692343
125Pallor (HP:0000980)1.73809680
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.73706506
127Gliosis (HP:0002171)1.72948077
128Nephrogenic diabetes insipidus (HP:0009806)1.72433990
129Triphalangeal thumb (HP:0001199)1.72295482
130Abnormality of methionine metabolism (HP:0010901)1.72211011
131Cellular immunodeficiency (HP:0005374)1.71306351
132Hypoplasia of the uterus (HP:0000013)1.71301985
133Impulsivity (HP:0100710)1.70834722
134Broad distal phalanx of finger (HP:0009836)1.70480060
135Hyperalaninemia (HP:0003348)1.69889281
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69889281
137Abnormality of alanine metabolism (HP:0010916)1.69889281
138Truncus arteriosus (HP:0001660)1.69584283
139Hyperglycinemia (HP:0002154)1.69417620
140Absent radius (HP:0003974)1.68663135
141Muscle fiber atrophy (HP:0100295)1.68089757
142Abnormal umbilical cord blood vessels (HP:0011403)1.67715372
143Single umbilical artery (HP:0001195)1.67715372
144Abnormality of the fetal cardiovascular system (HP:0010948)1.67715372
145Horseshoe kidney (HP:0000085)1.65644507
146Blindness (HP:0000618)1.63061983
147Redundant skin (HP:0001582)1.58902140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.19890170
2BUB14.57015389
3TAF13.49180446
4SMG13.19079086
5EIF2AK13.06266545
6STK162.97189260
7NUAK12.59653320
8WEE12.57967019
9BCKDK2.51297639
10EIF2AK32.46381803
11NME22.40699389
12NME12.26420489
13PLK42.25246540
14CASK2.23030444
15TSSK62.19805614
16VRK12.13261656
17SRPK12.04324321
18PBK2.04043442
19CCNB11.98555821
20MAP2K71.96297488
21MAP3K121.95417633
22ARAF1.83507708
23TESK11.83443320
24DYRK21.75096757
25PIM21.70784796
26LIMK11.69738675
27BRAF1.64084298
28PLK31.62809799
29BCR1.60034568
30PDK31.55427523
31PDK41.55427523
32BRSK21.50054820
33AKT31.49154797
34CSNK1A1L1.47018091
35BMPR1B1.45660559
36PNCK1.41967661
37MST41.41201888
38CSNK1G11.39503785
39MAP4K21.38437566
40PLK21.33745341
41MAP3K41.32259018
42CDC71.31110466
43BRSK11.30946446
44STK38L1.30094648
45CSNK1G21.25284567
46PLK11.23077249
47NEK11.22291183
48ZAK1.22041482
49SIK31.21957108
50MARK11.21631896
51TLK11.19942238
52MAPKAPK51.16533464
53MKNK11.14437406
54TRIM281.12235696
55AURKA1.11546016
56PRKD31.06277636
57TESK21.06027903
58CDK81.00083179
59PDK20.98579072
60MYLK0.98233686
61EIF2AK20.97931869
62TTK0.94875519
63MAPK130.90873460
64GRK50.86917757
65BMPR20.81550140
66PAK10.81472899
67NEK20.81397915
68ACVR1B0.80382430
69PASK0.78816847
70CDK90.78448521
71GRK70.75756815
72MUSK0.74346835
73CDK190.72660852
74MINK10.71957250
75KDR0.71767901
76CDK30.71294142
77AURKB0.69900077
78MKNK20.68994420
79STK240.67007196
80ABL20.66792996
81TAOK20.64836602
82CHEK20.63087901
83ADRBK20.62473686
84CSNK2A10.61155828
85DAPK10.61004678
86YES10.59043004
87DAPK30.57604582
88WNK30.56984394
89CDK180.56710795
90STK40.56510549
91ATR0.54107384
92ERBB30.53394291
93CDK140.53111749
94ILK0.52681816
95LATS20.52308369
96ATM0.48164449
97OBSCN0.46683272
98CDK150.46073615
99CSNK1G30.46014030
100CSNK2A20.45096117
101CHEK10.44398228
102CDK11A0.42605468
103IRAK30.42133048
104TIE10.42006222
105PRKCI0.41705849
106AKT20.41390690
107ALK0.40409414
108CDK40.40048929
109FLT30.39691916
110MAP3K110.39064950
111RPS6KA40.37738718
112DYRK30.37245043
113PRKCG0.37116812
114UHMK10.35317142
115CDK70.35018959
116CAMK2B0.34690504
117MAP2K40.34028128
118MELK0.34027397
119PTK2B0.33583606
120RPS6KA50.33467087
121ADRBK10.31340728
122MAP2K60.30877063
123CDK20.30147703
124EPHA20.29612601
125PRPF4B0.28988038
126PAK40.28522265
127LRRK20.28462900
128CDK10.28441042
129GRK10.27996300
130RPS6KB20.27764088
131MAP3K80.27577243
132CSNK1A10.27385860
133MAPK110.24232883
134CLK10.22433168
135TGFBR10.22166335
136CSNK1E0.20634074
137ERBB40.17638841

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.49479412
2RNA polymerase_Homo sapiens_hsa030204.08122441
3Oxidative phosphorylation_Homo sapiens_hsa001903.58044914
4Ribosome_Homo sapiens_hsa030103.46611122
5Parkinsons disease_Homo sapiens_hsa050123.11479697
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.04470564
7Sulfur relay system_Homo sapiens_hsa041222.94301847
8Huntingtons disease_Homo sapiens_hsa050162.65287584
9DNA replication_Homo sapiens_hsa030302.63833604
10Spliceosome_Homo sapiens_hsa030402.47503096
11Pyrimidine metabolism_Homo sapiens_hsa002402.44807046
12Basal transcription factors_Homo sapiens_hsa030222.42195898
13RNA transport_Homo sapiens_hsa030132.37316950
14Mismatch repair_Homo sapiens_hsa034302.32029081
15Protein export_Homo sapiens_hsa030602.07641542
16Alzheimers disease_Homo sapiens_hsa050102.04976947
17Homologous recombination_Homo sapiens_hsa034402.02653958
18Nucleotide excision repair_Homo sapiens_hsa034202.00266489
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80549954
20Base excision repair_Homo sapiens_hsa034101.72641908
21Collecting duct acid secretion_Homo sapiens_hsa049661.71984762
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66608417
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61494547
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61068284
25Cell cycle_Homo sapiens_hsa041101.60335794
26Purine metabolism_Homo sapiens_hsa002301.59506115
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55074588
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46003300
29Fanconi anemia pathway_Homo sapiens_hsa034601.42579899
30RNA degradation_Homo sapiens_hsa030181.38215420
31Sulfur metabolism_Homo sapiens_hsa009201.32367699
32Epstein-Barr virus infection_Homo sapiens_hsa051691.29006653
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22972173
34Vibrio cholerae infection_Homo sapiens_hsa051101.17564833
35Cardiac muscle contraction_Homo sapiens_hsa042601.16612224
36Vitamin B6 metabolism_Homo sapiens_hsa007501.10778220
37Rheumatoid arthritis_Homo sapiens_hsa053231.04403894
38Synaptic vesicle cycle_Homo sapiens_hsa047211.03583978
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01899821
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99018648
41mRNA surveillance pathway_Homo sapiens_hsa030150.98854632
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98062632
43Propanoate metabolism_Homo sapiens_hsa006400.91296244
44Non-homologous end-joining_Homo sapiens_hsa034500.90814097
45Oocyte meiosis_Homo sapiens_hsa041140.87399417
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81814102
47Type I diabetes mellitus_Homo sapiens_hsa049400.81060017
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79999228
49Arginine and proline metabolism_Homo sapiens_hsa003300.79025260
50Graft-versus-host disease_Homo sapiens_hsa053320.79024134
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77882128
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.77671256
53p53 signaling pathway_Homo sapiens_hsa041150.76867282
54Regulation of autophagy_Homo sapiens_hsa041400.75629721
55Allograft rejection_Homo sapiens_hsa053300.75468597
56Selenocompound metabolism_Homo sapiens_hsa004500.74561657
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73674627
58Peroxisome_Homo sapiens_hsa041460.71776527
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70911848
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69966443
61Fatty acid metabolism_Homo sapiens_hsa012120.67699067
62Legionellosis_Homo sapiens_hsa051340.67504441
63Phagosome_Homo sapiens_hsa041450.66914270
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64798755
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63857270
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59201743
67Butanoate metabolism_Homo sapiens_hsa006500.56059399
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.55562542
69One carbon pool by folate_Homo sapiens_hsa006700.53864542
70Steroid biosynthesis_Homo sapiens_hsa001000.53764733
71Arachidonic acid metabolism_Homo sapiens_hsa005900.53437323
72Pentose phosphate pathway_Homo sapiens_hsa000300.50706565
73Glutathione metabolism_Homo sapiens_hsa004800.49945280
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49370696
75Fructose and mannose metabolism_Homo sapiens_hsa000510.49308750
76Metabolic pathways_Homo sapiens_hsa011000.49034193
77Nicotine addiction_Homo sapiens_hsa050330.48693470
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48359787
79Basal cell carcinoma_Homo sapiens_hsa052170.46140215
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45344104
81beta-Alanine metabolism_Homo sapiens_hsa004100.44900788
82Autoimmune thyroid disease_Homo sapiens_hsa053200.43494385
83Asthma_Homo sapiens_hsa053100.39604269
84Linoleic acid metabolism_Homo sapiens_hsa005910.39551747
85Fatty acid degradation_Homo sapiens_hsa000710.39332630
86Shigellosis_Homo sapiens_hsa051310.38939567
87Ether lipid metabolism_Homo sapiens_hsa005650.36193845
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35758920
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35488092
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34689413
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34381401
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34109074
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33282051
94Herpes simplex infection_Homo sapiens_hsa051680.32872466
95Sphingolipid metabolism_Homo sapiens_hsa006000.30868117
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29797166
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28493600
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.28486887
99Alcoholism_Homo sapiens_hsa050340.28062630
100Serotonergic synapse_Homo sapiens_hsa047260.25859173
101Viral carcinogenesis_Homo sapiens_hsa052030.23286924
102Pyruvate metabolism_Homo sapiens_hsa006200.23026751
103Tyrosine metabolism_Homo sapiens_hsa003500.21865167
104Biosynthesis of amino acids_Homo sapiens_hsa012300.20164560
105Carbon metabolism_Homo sapiens_hsa012000.20020185
106Phototransduction_Homo sapiens_hsa047440.18871809
107Systemic lupus erythematosus_Homo sapiens_hsa053220.18276253
108N-Glycan biosynthesis_Homo sapiens_hsa005100.17856398
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17242795
110Folate biosynthesis_Homo sapiens_hsa007900.17054253
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16874491
112Salmonella infection_Homo sapiens_hsa051320.15896184
113Hedgehog signaling pathway_Homo sapiens_hsa043400.15625436
114Primary immunodeficiency_Homo sapiens_hsa053400.15000111
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14974458
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.13349593
117Tryptophan metabolism_Homo sapiens_hsa003800.12677036
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11975834
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11024151
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.10761154
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.10216236
122Antigen processing and presentation_Homo sapiens_hsa046120.09974849
123Galactose metabolism_Homo sapiens_hsa000520.09918611
124Influenza A_Homo sapiens_hsa051640.09757676
125HTLV-I infection_Homo sapiens_hsa051660.09317505
126Fatty acid elongation_Homo sapiens_hsa000620.08298483
127Phenylalanine metabolism_Homo sapiens_hsa003600.08287126
128Fat digestion and absorption_Homo sapiens_hsa049750.07811744
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07343335
130Apoptosis_Homo sapiens_hsa042100.07206676
131African trypanosomiasis_Homo sapiens_hsa051430.06438731
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05533675
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04147829
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.03589543
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02135129

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