

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.66885192 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.18813068 |
| 3 | vocalization behavior (GO:0071625) | 5.09963143 |
| 4 | synaptic vesicle exocytosis (GO:0016079) | 4.97881734 |
| 5 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.92703642 |
| 6 | neuronal action potential propagation (GO:0019227) | 4.81472279 |
| 7 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.75689411 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 4.74630983 |
| 9 | proteasome assembly (GO:0043248) | 4.63166110 |
| 10 | protein complex biogenesis (GO:0070271) | 4.50748170 |
| 11 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.49313674 |
| 12 | protein localization to synapse (GO:0035418) | 4.48018195 |
| 13 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.42934874 |
| 14 | glutamate secretion (GO:0014047) | 4.42820285 |
| 15 | locomotory exploration behavior (GO:0035641) | 4.24741369 |
| 16 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.21102056 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.20680562 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 4.20680562 |
| 19 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.20680562 |
| 20 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.16554758 |
| 21 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.15690932 |
| 22 | synaptic vesicle maturation (GO:0016188) | 4.12079238 |
| 23 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.08406796 |
| 24 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.07169566 |
| 25 | regulation of protein kinase A signaling (GO:0010738) | 4.05050554 |
| 26 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.03456310 |
| 27 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.98160159 |
| 28 | regulation of mitochondrial translation (GO:0070129) | 3.96908379 |
| 29 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.87402741 |
| 30 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.86305838 |
| 31 | ATP synthesis coupled proton transport (GO:0015986) | 3.86305838 |
| 32 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.85569655 |
| 33 | protein neddylation (GO:0045116) | 3.85082206 |
| 34 | regulation of synaptic vesicle transport (GO:1902803) | 3.84483057 |
| 35 | neurotransmitter secretion (GO:0007269) | 3.82798754 |
| 36 | transmission of nerve impulse (GO:0019226) | 3.82313649 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.82215784 |
| 38 | termination of RNA polymerase III transcription (GO:0006386) | 3.82215784 |
| 39 | glutamate receptor signaling pathway (GO:0007215) | 3.78114232 |
| 40 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.76887802 |
| 41 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.70625920 |
| 42 | neuron-neuron synaptic transmission (GO:0007270) | 3.70383969 |
| 43 | chaperone-mediated protein transport (GO:0072321) | 3.69386215 |
| 44 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.68007342 |
| 45 | rRNA modification (GO:0000154) | 3.67986187 |
| 46 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.66740333 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.66478772 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.66478772 |
| 49 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.66167926 |
| 50 | righting reflex (GO:0060013) | 3.65710969 |
| 51 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.65622395 |
| 52 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.64649884 |
| 53 | response to histamine (GO:0034776) | 3.64390439 |
| 54 | chromatin remodeling at centromere (GO:0031055) | 3.62789827 |
| 55 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.62205299 |
| 56 | cullin deneddylation (GO:0010388) | 3.61965582 |
| 57 | ribosomal small subunit assembly (GO:0000028) | 3.56893548 |
| 58 | CENP-A containing nucleosome assembly (GO:0034080) | 3.55751632 |
| 59 | exploration behavior (GO:0035640) | 3.55499628 |
| 60 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.55074817 |
| 61 | synaptic transmission, glutamatergic (GO:0035249) | 3.54852179 |
| 62 | neuron recognition (GO:0008038) | 3.52870359 |
| 63 | regulation of postsynaptic membrane potential (GO:0060078) | 3.52672195 |
| 64 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.51171670 |
| 65 | neuromuscular process controlling posture (GO:0050884) | 3.48180987 |
| 66 | pseudouridine synthesis (GO:0001522) | 3.46926733 |
| 67 | respiratory electron transport chain (GO:0022904) | 3.46746431 |
| 68 | respiratory chain complex IV assembly (GO:0008535) | 3.46210342 |
| 69 | establishment of integrated proviral latency (GO:0075713) | 3.45208691 |
| 70 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.45118982 |
| 71 | dendritic spine morphogenesis (GO:0060997) | 3.44314351 |
| 72 | regulation of synapse structural plasticity (GO:0051823) | 3.43629611 |
| 73 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.42982930 |
| 74 | DNA damage response, detection of DNA damage (GO:0042769) | 3.42583493 |
| 75 | protein targeting to mitochondrion (GO:0006626) | 3.40239739 |
| 76 | layer formation in cerebral cortex (GO:0021819) | 3.39493597 |
| 77 | DNA strand elongation (GO:0022616) | 3.38241692 |
| 78 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.37713400 |
| 79 | electron transport chain (GO:0022900) | 3.37585654 |
| 80 | neurotransmitter transport (GO:0006836) | 3.36932656 |
| 81 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.36729567 |
| 82 | protein deneddylation (GO:0000338) | 3.36047066 |
| 83 | oxidative phosphorylation (GO:0006119) | 3.36005347 |
| 84 | positive regulation of membrane potential (GO:0045838) | 3.35586579 |
| 85 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.34482190 |
| 86 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.34279974 |
| 87 | synaptic vesicle endocytosis (GO:0048488) | 3.33581972 |
| 88 | cytochrome complex assembly (GO:0017004) | 3.33449746 |
| 89 | establishment of protein localization to mitochondrion (GO:0072655) | 3.33138786 |
| 90 | presynaptic membrane assembly (GO:0097105) | 3.33056415 |
| 91 | detection of calcium ion (GO:0005513) | 3.32531189 |
| 92 | maturation of SSU-rRNA (GO:0030490) | 3.32180347 |
| 93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.30934974 |
| 94 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.30934974 |
| 95 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.30934974 |
| 96 | purine nucleobase biosynthetic process (GO:0009113) | 3.29947948 |
| 97 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.29708045 |
| 98 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.29672191 |
| 99 | membrane hyperpolarization (GO:0060081) | 3.29581058 |
| 100 | replication fork processing (GO:0031297) | 3.29322257 |
| 101 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.28822916 |
| 102 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.27989933 |
| 103 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.27989933 |
| 104 | cotranslational protein targeting to membrane (GO:0006613) | 3.27608318 |
| 105 | regulation of vesicle fusion (GO:0031338) | 3.26865788 |
| 106 | spliceosomal snRNP assembly (GO:0000387) | 3.26852862 |
| 107 | viral transcription (GO:0019083) | 3.26603278 |
| 108 | nucleobase biosynthetic process (GO:0046112) | 3.26082095 |
| 109 | ribosomal large subunit biogenesis (GO:0042273) | 3.26029989 |
| 110 | inner mitochondrial membrane organization (GO:0007007) | 3.25193130 |
| 111 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.24932978 |
| 112 | DNA replication checkpoint (GO:0000076) | 3.23072529 |
| 113 | translational termination (GO:0006415) | 3.21233509 |
| 114 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.21043151 |
| 115 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.21043151 |
| 116 | protein targeting to ER (GO:0045047) | 3.20988346 |
| 117 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.19550687 |
| 118 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.19053989 |
| 119 | long-term memory (GO:0007616) | 3.18534273 |
| 120 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.17330571 |
| 121 | translation (GO:0006412) | 3.17167291 |
| 122 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.16843899 |
| 123 | protein localization to mitochondrion (GO:0070585) | 3.16738459 |
| 124 | presynaptic membrane organization (GO:0097090) | 3.16316056 |
| 125 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.15851296 |
| 126 | regulation of neurotransmitter levels (GO:0001505) | 3.15548049 |
| 127 | activation of protein kinase A activity (GO:0034199) | 3.14356055 |
| 128 | positive regulation of ligase activity (GO:0051351) | 3.13869824 |
| 129 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.13458526 |
| 130 | GTP biosynthetic process (GO:0006183) | 3.13307021 |
| 131 | behavioral defense response (GO:0002209) | 3.11895728 |
| 132 | behavioral fear response (GO:0001662) | 3.11895728 |
| 133 | cellular component biogenesis (GO:0044085) | 3.10293977 |
| 134 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.09696771 |
| 135 | striatum development (GO:0021756) | 3.09670429 |
| 136 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.08718156 |
| 137 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.08718156 |
| 138 | protein localization to endoplasmic reticulum (GO:0070972) | 3.07347511 |
| 139 | ribosomal small subunit biogenesis (GO:0042274) | 3.07327514 |
| 140 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.07167157 |
| 141 | proline transport (GO:0015824) | 3.06852999 |
| 142 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.06273822 |
| 143 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.06257357 |
| 144 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.03244064 |
| 145 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.03160346 |
| 146 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.02805609 |
| 147 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.02115957 |
| 148 | base-excision repair, AP site formation (GO:0006285) | 3.01913008 |
| 149 | peptidyl-histidine modification (GO:0018202) | 3.00674460 |
| 150 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.00183239 |
| 151 | positive regulation of meiosis (GO:0045836) | 2.99802595 |
| 152 | ATP biosynthetic process (GO:0006754) | 2.98581937 |
| 153 | membrane depolarization (GO:0051899) | 2.98455227 |
| 154 | regulation of neurotransmitter secretion (GO:0046928) | 2.98285634 |
| 155 | translational elongation (GO:0006414) | 2.97732350 |
| 156 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.97442028 |
| 157 | axonal fasciculation (GO:0007413) | 2.97294940 |
| 158 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.96810011 |
| 159 | postsynaptic membrane organization (GO:0001941) | 2.96056580 |
| 160 | fear response (GO:0042596) | 2.95915675 |
| 161 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.95765675 |
| 162 | mannosylation (GO:0097502) | 2.93466605 |
| 163 | regulation of glutamate secretion (GO:0014048) | 2.93289706 |
| 164 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.92866078 |
| 165 | rRNA processing (GO:0006364) | 2.92190525 |
| 166 | oxygen transport (GO:0015671) | 2.92076923 |
| 167 | behavioral response to cocaine (GO:0048148) | 2.92073754 |
| 168 | establishment of viral latency (GO:0019043) | 2.91603497 |
| 169 | UTP biosynthetic process (GO:0006228) | 2.91083242 |
| 170 | membrane depolarization during action potential (GO:0086010) | 2.89870661 |
| 171 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.89865198 |
| 172 | mitotic recombination (GO:0006312) | 2.89567481 |
| 173 | kinetochore assembly (GO:0051382) | 2.89118766 |
| 174 | telomere maintenance via recombination (GO:0000722) | 2.88357388 |
| 175 | maturation of 5.8S rRNA (GO:0000460) | 2.87889361 |
| 176 | protein localization to kinetochore (GO:0034501) | 2.87711030 |
| 177 | neuronal ion channel clustering (GO:0045161) | 2.86922008 |
| 178 | regulation of synaptic plasticity (GO:0048167) | 2.85603989 |
| 179 | gamma-aminobutyric acid transport (GO:0015812) | 2.84785422 |
| 180 | auditory behavior (GO:0031223) | 2.84718602 |
| 181 | startle response (GO:0001964) | 2.84395080 |
| 182 | adult walking behavior (GO:0007628) | 2.84253994 |
| 183 | regulation of neurotransmitter transport (GO:0051588) | 2.83368888 |
| 184 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.80285887 |
| 185 | synaptic transmission (GO:0007268) | 2.80260043 |
| 186 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.78252222 |
| 187 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.78151204 |
| 188 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.77926623 |
| 189 | intraspecies interaction between organisms (GO:0051703) | 2.77676181 |
| 190 | social behavior (GO:0035176) | 2.77676181 |
| 191 | neurotransmitter catabolic process (GO:0042135) | 2.77619219 |
| 192 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.77334452 |
| 193 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.76656492 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.38477650 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.54200481 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.93538016 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.56041485 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.22747073 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.96032247 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.66700562 |
| 8 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.48327164 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.43396152 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.42168324 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.31913005 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.23841984 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.17261786 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.16091702 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.04514196 |
| 16 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.99355910 |
| 17 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.92859947 |
| 18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.83303340 |
| 19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.82390394 |
| 20 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.78257119 |
| 21 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.66995360 |
| 22 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.63524794 |
| 23 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.60761667 |
| 24 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.60761667 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.59902688 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.59137032 |
| 27 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.59003466 |
| 28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.57765058 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.57657532 |
| 30 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.51680382 |
| 31 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.47347840 |
| 32 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.45818781 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.44103037 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43353737 |
| 35 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.41606709 |
| 36 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.36783271 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.32941205 |
| 38 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.31666397 |
| 39 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.26674308 |
| 40 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.24995327 |
| 41 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.24115208 |
| 42 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.21704923 |
| 43 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.21673016 |
| 44 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.19720722 |
| 45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.18322857 |
| 46 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17931691 |
| 47 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.14179509 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.13485783 |
| 49 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.11879110 |
| 50 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.10866246 |
| 51 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.09775256 |
| 52 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.08664344 |
| 53 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.05919260 |
| 54 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.05210790 |
| 55 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.03646172 |
| 56 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.01844554 |
| 57 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.94383509 |
| 58 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.93414785 |
| 59 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.87971067 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.87816165 |
| 61 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.86778218 |
| 62 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.86558404 |
| 63 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.86066176 |
| 64 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.85702967 |
| 65 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84175074 |
| 66 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.79567772 |
| 67 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77733435 |
| 68 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.76653531 |
| 69 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.76580576 |
| 70 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.75860584 |
| 71 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.74413791 |
| 72 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.72840012 |
| 73 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.72461799 |
| 74 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.72095784 |
| 75 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.71648154 |
| 76 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.68226387 |
| 77 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.68222286 |
| 78 | FUS_26573619_Chip-Seq_HEK293_Human | 1.63280897 |
| 79 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.63167823 |
| 80 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61848430 |
| 81 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.59952494 |
| 82 | P300_19829295_ChIP-Seq_ESCs_Human | 1.55290360 |
| 83 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.54155090 |
| 84 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.53262561 |
| 85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.50813353 |
| 86 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.50148146 |
| 87 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.48935502 |
| 88 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.48909025 |
| 89 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.45439703 |
| 90 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.39067406 |
| 91 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.38916370 |
| 92 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.37781335 |
| 93 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.34576498 |
| 94 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.33667056 |
| 95 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.31429170 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.30871675 |
| 97 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.30172158 |
| 98 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.29025984 |
| 99 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.27896144 |
| 100 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.27308837 |
| 101 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.27118007 |
| 102 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.26937410 |
| 103 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.23789008 |
| 104 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.22655409 |
| 105 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.21983134 |
| 106 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.20892544 |
| 107 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.20534718 |
| 108 | STAT3_23295773_ChIP-Seq_U87_Human | 1.20287288 |
| 109 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.20158133 |
| 110 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.20120762 |
| 111 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.18271560 |
| 112 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.17120613 |
| 113 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17038096 |
| 114 | TCF4_23295773_ChIP-Seq_U87_Human | 1.16101477 |
| 115 | AR_25329375_ChIP-Seq_VCAP_Human | 1.16009825 |
| 116 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.15446502 |
| 117 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.14245708 |
| 118 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13540884 |
| 119 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.13411439 |
| 120 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13329081 |
| 121 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.13094900 |
| 122 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.12871320 |
| 123 | EWS_26573619_Chip-Seq_HEK293_Human | 1.12750440 |
| 124 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.12111689 |
| 125 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.11681472 |
| 126 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.10890629 |
| 127 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.10709039 |
| 128 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.10692665 |
| 129 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.09210797 |
| 130 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08298824 |
| 131 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07730887 |
| 132 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.07669625 |
| 133 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.07303430 |
| 134 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.07233358 |
| 135 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.07060941 |
| 136 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.06574456 |
| 137 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.06488721 |
| 138 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.06244930 |
| 139 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06129259 |
| 140 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05927360 |
| 141 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.05649141 |
| 142 | VDR_22108803_ChIP-Seq_LS180_Human | 1.05236327 |
| 143 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.05092008 |
| 144 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04863903 |
| 145 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.04854500 |
| 146 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.04755547 |
| 147 | JUN_21703547_ChIP-Seq_K562_Human | 1.04553194 |
| 148 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.03184197 |
| 149 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02703722 |
| 150 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.02169915 |
| 151 | AR_19668381_ChIP-Seq_PC3_Human | 1.02006792 |
| 152 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.01896091 |
| 153 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.01802933 |
| 154 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01802933 |
| 155 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.99892906 |
| 156 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.98831727 |
| 157 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.98732251 |
| 158 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.97436085 |
| 159 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.97252712 |
| 160 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.96794979 |
| 161 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.96773664 |
| 162 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.94998362 |
| 163 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.94993131 |
| 164 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.94108149 |
| 165 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.92674947 |
| 166 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90176680 |
| 167 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.89840181 |
| 168 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.89383555 |
| 169 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.89212612 |
| 170 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.88275856 |
| 171 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.87836690 |
| 172 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.87667384 |
| 173 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.86780976 |
| 174 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.85921899 |
| 175 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.85603057 |
| 176 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.85530911 |
| 177 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.85374824 |
| 178 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.85290491 |
| 179 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85067424 |
| 180 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83889472 |
| 181 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.83430149 |
| 182 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.82280491 |
| 183 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80955922 |
| 184 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80541282 |
| 185 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.78602092 |
| 186 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.78358894 |
| 187 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.77924891 |
| 188 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73627259 |
| 189 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.73401616 |
| 190 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.69583295 |
| 191 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.66899705 |
| 192 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.66102802 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.42647350 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.94569318 |
| 3 | MP0008058_abnormal_DNA_repair | 3.89983122 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.59172245 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.54194296 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 3.51273190 |
| 7 | MP0003693_abnormal_embryo_hatching | 3.49761197 |
| 8 | MP0009745_abnormal_behavioral_response | 3.10879783 |
| 9 | MP0004270_analgesia | 3.10712525 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.95882963 |
| 11 | MP0002064_seizures | 2.89468694 |
| 12 | MP0009046_muscle_twitch | 2.88481264 |
| 13 | MP0001529_abnormal_vocalization | 2.86484424 |
| 14 | MP0002063_abnormal_learning/memory/cond | 2.81826864 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 2.73829757 |
| 16 | MP0003111_abnormal_nucleus_morphology | 2.70317776 |
| 17 | MP0003806_abnormal_nucleotide_metabolis | 2.64061697 |
| 18 | MP0003786_premature_aging | 2.62350767 |
| 19 | MP0000372_irregular_coat_pigmentation | 2.61973743 |
| 20 | MP0005423_abnormal_somatic_nervous | 2.59364695 |
| 21 | MP0002572_abnormal_emotion/affect_behav | 2.54418933 |
| 22 | MP0003186_abnormal_redox_activity | 2.50087077 |
| 23 | MP0002736_abnormal_nociception_after | 2.45008098 |
| 24 | MP0001486_abnormal_startle_reflex | 2.44938596 |
| 25 | MP0002272_abnormal_nervous_system | 2.44352233 |
| 26 | MP0008007_abnormal_cellular_replicative | 2.39877235 |
| 27 | MP0003646_muscle_fatigue | 2.38662861 |
| 28 | MP0001440_abnormal_grooming_behavior | 2.38428955 |
| 29 | MP0002734_abnormal_mechanical_nocicepti | 2.35570306 |
| 30 | MP0000751_myopathy | 2.35545691 |
| 31 | MP0003077_abnormal_cell_cycle | 2.35529693 |
| 32 | MP0002822_catalepsy | 2.34685413 |
| 33 | MP0008932_abnormal_embryonic_tissue | 2.30785400 |
| 34 | MP0003718_maternal_effect | 2.25061869 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 2.24877143 |
| 36 | MP0006276_abnormal_autonomic_nervous | 2.23178905 |
| 37 | MP0002938_white_spotting | 2.22695720 |
| 38 | MP0001501_abnormal_sleep_pattern | 2.13782376 |
| 39 | MP0003136_yellow_coat_color | 1.99754966 |
| 40 | MP0004147_increased_porphyrin_level | 1.99279387 |
| 41 | MP0005386_behavior/neurological_phenoty | 1.94705602 |
| 42 | MP0004924_abnormal_behavior | 1.94705602 |
| 43 | MP0002067_abnormal_sensory_capabilities | 1.88951178 |
| 44 | MP0009697_abnormal_copulation | 1.86741159 |
| 45 | MP0001970_abnormal_pain_threshold | 1.82179830 |
| 46 | MP0001905_abnormal_dopamine_level | 1.81441046 |
| 47 | MP0004215_abnormal_myocardial_fiber | 1.75905555 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.69088681 |
| 49 | MP0002733_abnormal_thermal_nociception | 1.68140348 |
| 50 | MP0002735_abnormal_chemical_nociception | 1.61930474 |
| 51 | MP0008995_early_reproductive_senescence | 1.61218365 |
| 52 | MP0004142_abnormal_muscle_tone | 1.60576043 |
| 53 | MP0002184_abnormal_innervation | 1.58007283 |
| 54 | MP0008789_abnormal_olfactory_epithelium | 1.56886172 |
| 55 | MP0002557_abnormal_social/conspecific_i | 1.51886941 |
| 56 | MP0000778_abnormal_nervous_system | 1.50997011 |
| 57 | MP0008569_lethality_at_weaning | 1.46823962 |
| 58 | MP0001293_anophthalmia | 1.45736932 |
| 59 | MP0010030_abnormal_orbit_morphology | 1.44176188 |
| 60 | MP0004145_abnormal_muscle_electrophysio | 1.42930455 |
| 61 | MP0002160_abnormal_reproductive_system | 1.39897448 |
| 62 | MP0003329_amyloid_beta_deposits | 1.38265097 |
| 63 | MP0000358_abnormal_cell_content/ | 1.38117459 |
| 64 | MP0003787_abnormal_imprinting | 1.37010950 |
| 65 | MP0001502_abnormal_circadian_rhythm | 1.34062043 |
| 66 | MP0009379_abnormal_foot_pigmentation | 1.33201689 |
| 67 | MP0004036_abnormal_muscle_relaxation | 1.32228429 |
| 68 | MP0002066_abnormal_motor_capabilities/c | 1.29671804 |
| 69 | MP0003137_abnormal_impulse_conducting | 1.28570408 |
| 70 | MP0006292_abnormal_olfactory_placode | 1.28400522 |
| 71 | MP0005253_abnormal_eye_physiology | 1.28207084 |
| 72 | MP0002653_abnormal_ependyma_morphology | 1.28003366 |
| 73 | MP0004084_abnormal_cardiac_muscle | 1.26223039 |
| 74 | MP0005084_abnormal_gallbladder_morpholo | 1.25992012 |
| 75 | MP0000955_abnormal_spinal_cord | 1.25357843 |
| 76 | MP0002882_abnormal_neuron_morphology | 1.24463027 |
| 77 | MP0002234_abnormal_pharynx_morphology | 1.24131397 |
| 78 | MP0002210_abnormal_sex_determination | 1.23620842 |
| 79 | MP0003011_delayed_dark_adaptation | 1.22970333 |
| 80 | MP0001188_hyperpigmentation | 1.20882846 |
| 81 | MP0001984_abnormal_olfaction | 1.19662757 |
| 82 | MP0004811_abnormal_neuron_physiology | 1.17925286 |
| 83 | MP0005075_abnormal_melanosome_morpholog | 1.17079148 |
| 84 | MP0004085_abnormal_heartbeat | 1.14459959 |
| 85 | MP0008877_abnormal_DNA_methylation | 1.13527395 |
| 86 | MP0002909_abnormal_adrenal_gland | 1.08847903 |
| 87 | MP0005171_absent_coat_pigmentation | 1.08470448 |
| 88 | MP0003122_maternal_imprinting | 1.08321217 |
| 89 | MP0001764_abnormal_homeostasis | 1.08074382 |
| 90 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07490252 |
| 91 | MP0005551_abnormal_eye_electrophysiolog | 1.07219424 |
| 92 | MP0003879_abnormal_hair_cell | 1.06735554 |
| 93 | MP0008057_abnormal_DNA_replication | 1.06452632 |
| 94 | MP0001929_abnormal_gametogenesis | 1.04258396 |
| 95 | MP0005389_reproductive_system_phenotype | 1.03687483 |
| 96 | MP0002102_abnormal_ear_morphology | 1.01998781 |
| 97 | MP0003195_calcinosis | 1.01002991 |
| 98 | MP0008875_abnormal_xenobiotic_pharmacok | 1.00920159 |
| 99 | MP0002152_abnormal_brain_morphology | 0.99635562 |
| 100 | MP0000653_abnormal_sex_gland | 0.96314290 |
| 101 | MP0006072_abnormal_retinal_apoptosis | 0.96226245 |
| 102 | MP0001145_abnormal_male_reproductive | 0.96074959 |
| 103 | MP0004484_altered_response_of | 0.96033811 |
| 104 | MP0005408_hypopigmentation | 0.95347696 |
| 105 | MP0008872_abnormal_physiological_respon | 0.95215022 |
| 106 | MP0005645_abnormal_hypothalamus_physiol | 0.94764246 |
| 107 | MP0002090_abnormal_vision | 0.94694703 |
| 108 | MP0002095_abnormal_skin_pigmentation | 0.94477348 |
| 109 | MP0004742_abnormal_vestibular_system | 0.92182832 |
| 110 | MP0000049_abnormal_middle_ear | 0.91852597 |
| 111 | MP0005409_darkened_coat_color | 0.91240667 |
| 112 | MP0000350_abnormal_cell_proliferation | 0.90545147 |
| 113 | MP0005379_endocrine/exocrine_gland_phen | 0.89282386 |
| 114 | MP0010386_abnormal_urinary_bladder | 0.88955665 |
| 115 | MP0002229_neurodegeneration | 0.87841577 |
| 116 | MP0003631_nervous_system_phenotype | 0.86999670 |
| 117 | MP0004133_heterotaxia | 0.86791433 |
| 118 | MP0005330_cardiomyopathy | 0.85768378 |
| 119 | MP0003315_abnormal_perineum_morphology | 0.85358396 |
| 120 | MP0003123_paternal_imprinting | 0.85325105 |
| 121 | MP0001485_abnormal_pinna_reflex | 0.84598349 |
| 122 | MP0005535_abnormal_body_temperature | 0.84081022 |
| 123 | MP0005623_abnormal_meninges_morphology | 0.84054575 |
| 124 | MP0003633_abnormal_nervous_system | 0.83322309 |
| 125 | MP0009780_abnormal_chondrocyte_physiolo | 0.82098272 |
| 126 | MP0005391_vision/eye_phenotype | 0.81893239 |
| 127 | MP0005332_abnormal_amino_acid | 0.81788829 |
| 128 | MP0002752_abnormal_somatic_nervous | 0.81502759 |
| 129 | MP0002638_abnormal_pupillary_reflex | 0.81053010 |
| 130 | MP0000749_muscle_degeneration | 0.80981007 |
| 131 | MP0002751_abnormal_autonomic_nervous | 0.80496985 |
| 132 | MP0001697_abnormal_embryo_size | 0.80357309 |
| 133 | MP0003119_abnormal_digestive_system | 0.80144268 |
| 134 | MP0003937_abnormal_limbs/digits/tail_de | 0.79606060 |
| 135 | MP0003121_genomic_imprinting | 0.79583268 |
| 136 | MP0000313_abnormal_cell_death | 0.79271101 |
| 137 | MP0005620_abnormal_muscle_contractility | 0.78739992 |
| 138 | MP0001119_abnormal_female_reproductive | 0.78549983 |
| 139 | MP0003698_abnormal_male_reproductive | 0.78082003 |
| 140 | MP0008874_decreased_physiological_sensi | 0.77990382 |
| 141 | MP0002277_abnormal_respiratory_mucosa | 0.77865346 |
| 142 | MP0000647_abnormal_sebaceous_gland | 0.77728315 |
| 143 | MP0001346_abnormal_lacrimal_gland | 0.77270501 |
| 144 | MP0001730_embryonic_growth_arrest | 0.77205537 |
| 145 | MP0000631_abnormal_neuroendocrine_gland | 0.76093782 |
| 146 | MP0000747_muscle_weakness | 0.75770297 |
| 147 | MP0001286_abnormal_eye_development | 0.75612206 |
| 148 | MP0002332_abnormal_exercise_endurance | 0.75249820 |
| 149 | MP0002069_abnormal_eating/drinking_beha | 0.74576642 |
| 150 | MP0001919_abnormal_reproductive_system | 0.74291170 |
| 151 | MP0002106_abnormal_muscle_physiology | 0.73566928 |
| 152 | MP0001963_abnormal_hearing_physiology | 0.73213271 |
| 153 | MP0003632_abnormal_nervous_system | 0.72771800 |
| 154 | MP0002972_abnormal_cardiac_muscle | 0.71338459 |
| 155 | MP0001177_atelectasis | 0.69662552 |
| 156 | MP0005195_abnormal_posterior_eye | 0.68598003 |
| 157 | MP0005394_taste/olfaction_phenotype | 0.68596678 |
| 158 | MP0005499_abnormal_olfactory_system | 0.68596678 |
| 159 | MP0002282_abnormal_trachea_morphology | 0.68073592 |
| 160 | MP0006138_congestive_heart_failure | 0.67621431 |
| 161 | MP0002163_abnormal_gland_morphology | 0.66088899 |
| 162 | MP0005369_muscle_phenotype | 0.65976228 |
| 163 | MP0004510_myositis | 0.63788598 |
| 164 | MP0004858_abnormal_nervous_system | 0.61274264 |
| 165 | MP0001727_abnormal_embryo_implantation | 0.60604554 |
| 166 | MP0006035_abnormal_mitochondrial_morpho | 0.58325638 |
| 167 | MP0001943_abnormal_respiration | 0.57883281 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.66986143 |
| 2 | Myokymia (HP:0002411) | 5.77754090 |
| 3 | Focal seizures (HP:0007359) | 5.26440910 |
| 4 | Atonic seizures (HP:0010819) | 4.80400912 |
| 5 | Visual hallucinations (HP:0002367) | 4.51211963 |
| 6 | Febrile seizures (HP:0002373) | 4.31558439 |
| 7 | Hepatic necrosis (HP:0002605) | 3.96534709 |
| 8 | Absence seizures (HP:0002121) | 3.89882080 |
| 9 | Cerebral edema (HP:0002181) | 3.85385643 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.84463346 |
| 11 | Epileptic encephalopathy (HP:0200134) | 3.63228857 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.62994882 |
| 13 | Sudden death (HP:0001699) | 3.55011458 |
| 14 | Dialeptic seizures (HP:0011146) | 3.54936094 |
| 15 | Acute necrotizing encephalopathy (HP:0006965) | 3.54156290 |
| 16 | Generalized tonic-clonic seizures (HP:0002069) | 3.43299291 |
| 17 | Progressive cerebellar ataxia (HP:0002073) | 3.39739130 |
| 18 | Type I transferrin isoform profile (HP:0003642) | 3.39190731 |
| 19 | Broad-based gait (HP:0002136) | 3.34835108 |
| 20 | Progressive macrocephaly (HP:0004481) | 3.17874408 |
| 21 | Reticulocytopenia (HP:0001896) | 3.17397923 |
| 22 | Increased serum lactate (HP:0002151) | 3.16772175 |
| 23 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.16268544 |
| 24 | Increased intramyocellular lipid droplets (HP:0012240) | 3.15525045 |
| 25 | Lactic acidosis (HP:0003128) | 3.10080107 |
| 26 | Amblyopia (HP:0000646) | 3.07767100 |
| 27 | Gaze-evoked nystagmus (HP:0000640) | 3.03872065 |
| 28 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03022135 |
| 29 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.00309561 |
| 30 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.00309561 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 2.98816872 |
| 32 | Mitochondrial inheritance (HP:0001427) | 2.93159239 |
| 33 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.85975059 |
| 34 | Exercise intolerance (HP:0003546) | 2.84130747 |
| 35 | Abnormal protein glycosylation (HP:0012346) | 2.82391712 |
| 36 | Abnormal glycosylation (HP:0012345) | 2.82391712 |
| 37 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.82391712 |
| 38 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.82391712 |
| 39 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.81653016 |
| 40 | Respiratory failure (HP:0002878) | 2.78779580 |
| 41 | Dysmetria (HP:0001310) | 2.77071031 |
| 42 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.74449051 |
| 43 | Anxiety (HP:0000739) | 2.74052545 |
| 44 | Nuclear cataract (HP:0100018) | 2.73933689 |
| 45 | Calf muscle hypertrophy (HP:0008981) | 2.71724859 |
| 46 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.70626509 |
| 47 | Action tremor (HP:0002345) | 2.66637853 |
| 48 | Acute encephalopathy (HP:0006846) | 2.65273437 |
| 49 | Dysdiadochokinesis (HP:0002075) | 2.64088683 |
| 50 | Abnormality of midbrain morphology (HP:0002418) | 2.60005038 |
| 51 | Molar tooth sign on MRI (HP:0002419) | 2.60005038 |
| 52 | Meckel diverticulum (HP:0002245) | 2.59184548 |
| 53 | Poor eye contact (HP:0000817) | 2.59182792 |
| 54 | Fetal akinesia sequence (HP:0001989) | 2.58733497 |
| 55 | Increased muscle lipid content (HP:0009058) | 2.56322028 |
| 56 | Leukodystrophy (HP:0002415) | 2.56043755 |
| 57 | Exertional dyspnea (HP:0002875) | 2.52454371 |
| 58 | Abnormality of the ileum (HP:0001549) | 2.52118481 |
| 59 | Respiratory difficulties (HP:0002880) | 2.50535220 |
| 60 | Reduced antithrombin III activity (HP:0001976) | 2.50075872 |
| 61 | Zonular cataract (HP:0010920) | 2.49389853 |
| 62 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.48667716 |
| 63 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.48490218 |
| 64 | Abnormality of the labia minora (HP:0012880) | 2.48388512 |
| 65 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.47184021 |
| 66 | Microvesicular hepatic steatosis (HP:0001414) | 2.45427145 |
| 67 | Colon cancer (HP:0003003) | 2.44699844 |
| 68 | Ventricular fibrillation (HP:0001663) | 2.43806827 |
| 69 | Lethargy (HP:0001254) | 2.42206798 |
| 70 | Atrial fibrillation (HP:0005110) | 2.41926502 |
| 71 | Increased serum pyruvate (HP:0003542) | 2.41912108 |
| 72 | Primary atrial arrhythmia (HP:0001692) | 2.39532734 |
| 73 | Hyperglycinemia (HP:0002154) | 2.38909348 |
| 74 | Macrocytic anemia (HP:0001972) | 2.37947914 |
| 75 | Chromsome breakage (HP:0040012) | 2.35578562 |
| 76 | Increased CSF lactate (HP:0002490) | 2.34628370 |
| 77 | Myotonia (HP:0002486) | 2.34546818 |
| 78 | Type 2 muscle fiber atrophy (HP:0003554) | 2.34257790 |
| 79 | Abnormality of glycolysis (HP:0004366) | 2.34237766 |
| 80 | Syncope (HP:0001279) | 2.32673983 |
| 81 | Pancreatic cysts (HP:0001737) | 2.28795655 |
| 82 | Truncal ataxia (HP:0002078) | 2.27398850 |
| 83 | Supraventricular tachycardia (HP:0004755) | 2.27113921 |
| 84 | Impaired social interactions (HP:0000735) | 2.26709231 |
| 85 | Abnormal social behavior (HP:0012433) | 2.26709231 |
| 86 | Abnormal eating behavior (HP:0100738) | 2.25936455 |
| 87 | Bundle branch block (HP:0011710) | 2.25882634 |
| 88 | Ankle clonus (HP:0011448) | 2.24375458 |
| 89 | Optic disc pallor (HP:0000543) | 2.23904947 |
| 90 | Pancytopenia (HP:0001876) | 2.23640383 |
| 91 | Gait imbalance (HP:0002141) | 2.23468711 |
| 92 | Testicular atrophy (HP:0000029) | 2.23224639 |
| 93 | Pancreatic fibrosis (HP:0100732) | 2.22776789 |
| 94 | Pheochromocytoma (HP:0002666) | 2.21207608 |
| 95 | Hyperventilation (HP:0002883) | 2.20955661 |
| 96 | Abnormality of the preputium (HP:0100587) | 2.18849271 |
| 97 | Abnormality of alanine metabolism (HP:0010916) | 2.18823409 |
| 98 | Hyperalaninemia (HP:0003348) | 2.18823409 |
| 99 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.18823409 |
| 100 | Congenital primary aphakia (HP:0007707) | 2.18427202 |
| 101 | Methylmalonic aciduria (HP:0012120) | 2.18263812 |
| 102 | Hepatocellular necrosis (HP:0001404) | 2.18224367 |
| 103 | Supraventricular arrhythmia (HP:0005115) | 2.18071955 |
| 104 | Delusions (HP:0000746) | 2.16279611 |
| 105 | Hemiparesis (HP:0001269) | 2.15905813 |
| 106 | Abnormality of the anterior horn cell (HP:0006802) | 2.15117312 |
| 107 | Degeneration of anterior horn cells (HP:0002398) | 2.15117312 |
| 108 | Dysmetric saccades (HP:0000641) | 2.14927889 |
| 109 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.14897759 |
| 110 | Prolonged QT interval (HP:0001657) | 2.14448663 |
| 111 | Depression (HP:0000716) | 2.14354029 |
| 112 | Progressive inability to walk (HP:0002505) | 2.13484623 |
| 113 | Abnormality of methionine metabolism (HP:0010901) | 2.13166533 |
| 114 | Increased hepatocellular lipid droplets (HP:0006565) | 2.13030807 |
| 115 | Limb dystonia (HP:0002451) | 2.11903302 |
| 116 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.11711925 |
| 117 | Methylmalonic acidemia (HP:0002912) | 2.11427819 |
| 118 | Supranuclear gaze palsy (HP:0000605) | 2.11107039 |
| 119 | Muscle fiber splitting (HP:0003555) | 2.11105944 |
| 120 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.10865115 |
| 121 | Muscle fiber atrophy (HP:0100295) | 2.10255661 |
| 122 | Absent/shortened dynein arms (HP:0200106) | 2.09825437 |
| 123 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.09825437 |
| 124 | Birth length less than 3rd percentile (HP:0003561) | 2.09645679 |
| 125 | Abnormality of the calf musculature (HP:0001430) | 2.09195837 |
| 126 | Absent thumb (HP:0009777) | 2.08712942 |
| 127 | Unsteady gait (HP:0002317) | 2.07383954 |
| 128 | Genetic anticipation (HP:0003743) | 2.05428683 |
| 129 | Neurofibrillary tangles (HP:0002185) | 2.04905271 |
| 130 | Neuroendocrine neoplasm (HP:0100634) | 2.04836520 |
| 131 | Postural instability (HP:0002172) | 2.04482984 |
| 132 | Left ventricular hypertrophy (HP:0001712) | 2.04310929 |
| 133 | Spastic gait (HP:0002064) | 2.01969335 |
| 134 | CNS demyelination (HP:0007305) | 2.01681933 |
| 135 | Microretrognathia (HP:0000308) | 2.01418829 |
| 136 | Abnormal EKG (HP:0003115) | 2.00676873 |
| 137 | Abnormality of serum amino acid levels (HP:0003112) | 2.00541019 |
| 138 | Scanning speech (HP:0002168) | 1.98661616 |
| 139 | Abnormality of renal resorption (HP:0011038) | 1.98194130 |
| 140 | Cerebral inclusion bodies (HP:0100314) | 1.98108028 |
| 141 | Aplastic anemia (HP:0001915) | 1.98007129 |
| 142 | Bradykinesia (HP:0002067) | 1.97519177 |
| 143 | True hermaphroditism (HP:0010459) | 1.95527440 |
| 144 | Cerebral hypomyelination (HP:0006808) | 1.94169991 |
| 145 | Hypoplasia of the pons (HP:0012110) | 1.93937852 |
| 146 | Sclerocornea (HP:0000647) | 1.91710495 |
| 147 | Abnormal ciliary motility (HP:0012262) | 1.91140369 |
| 148 | Incomplete penetrance (HP:0003829) | 1.90873933 |
| 149 | Epileptiform EEG discharges (HP:0011182) | 1.88776107 |
| 150 | Urinary urgency (HP:0000012) | 1.88324004 |
| 151 | Generalized myoclonic seizures (HP:0002123) | 1.87888354 |
| 152 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.87799166 |
| 153 | Rapidly progressive (HP:0003678) | 1.87759012 |
| 154 | Abnormality of chromosome stability (HP:0003220) | 1.87324830 |
| 155 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.86709283 |
| 156 | Drooling (HP:0002307) | 1.86448425 |
| 157 | Excessive salivation (HP:0003781) | 1.86448425 |
| 158 | Impaired vibratory sensation (HP:0002495) | 1.85760074 |
| 159 | X-linked dominant inheritance (HP:0001423) | 1.85684495 |
| 160 | Abnormality of urine glucose concentration (HP:0011016) | 1.85285398 |
| 161 | Glycosuria (HP:0003076) | 1.85285398 |
| 162 | Medial flaring of the eyebrow (HP:0010747) | 1.85243985 |
| 163 | EEG with generalized epileptiform discharges (HP:0011198) | 1.84419599 |
| 164 | Abnormality of the pons (HP:0007361) | 1.83785933 |
| 165 | Insidious onset (HP:0003587) | 1.82466918 |
| 166 | Termporal pattern (HP:0011008) | 1.82466918 |
| 167 | Small intestinal stenosis (HP:0012848) | 1.82132415 |
| 168 | Duodenal stenosis (HP:0100867) | 1.82132415 |
| 169 | Impaired smooth pursuit (HP:0007772) | 1.81954737 |
| 170 | Esotropia (HP:0000565) | 1.81916955 |
| 171 | Genital tract atresia (HP:0001827) | 1.80945890 |
| 172 | Emotional lability (HP:0000712) | 1.80486515 |
| 173 | Absent speech (HP:0001344) | 1.80299464 |
| 174 | Horseshoe kidney (HP:0000085) | 1.75493932 |
| 175 | Papilledema (HP:0001085) | 1.75082619 |
| 176 | Opisthotonus (HP:0002179) | 1.74957768 |
| 177 | Abnormality of binocular vision (HP:0011514) | 1.74946729 |
| 178 | Diplopia (HP:0000651) | 1.74946729 |
| 179 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.74894240 |
| 180 | Nephronophthisis (HP:0000090) | 1.74802333 |
| 181 | Polyphagia (HP:0002591) | 1.74343500 |
| 182 | Pendular nystagmus (HP:0012043) | 1.73462507 |
| 183 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.73374997 |
| 184 | Dicarboxylic aciduria (HP:0003215) | 1.73374997 |
| 185 | Abnormal lung lobation (HP:0002101) | 1.72369489 |
| 186 | Triphalangeal thumb (HP:0001199) | 1.70406058 |
| 187 | Generalized aminoaciduria (HP:0002909) | 1.70039987 |
| 188 | Pallor (HP:0000980) | 1.69441584 |
| 189 | Blindness (HP:0000618) | 1.66347592 |
| 190 | Abnormality of the duodenum (HP:0002246) | 1.66323296 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.60957322 |
| 2 | BUB1 | 4.34276430 |
| 3 | EPHA4 | 4.01568265 |
| 4 | MAP3K9 | 3.89290615 |
| 5 | MAP3K4 | 3.70488874 |
| 6 | NTRK3 | 3.44940060 |
| 7 | ZAK | 3.01783185 |
| 8 | MAP2K7 | 2.97378739 |
| 9 | VRK1 | 2.96809246 |
| 10 | MAP3K12 | 2.83588971 |
| 11 | STK16 | 2.53430079 |
| 12 | SRPK1 | 2.46790478 |
| 13 | ARAF | 2.40286119 |
| 14 | CDC7 | 2.36612713 |
| 15 | TAF1 | 2.32445360 |
| 16 | TNIK | 2.24561998 |
| 17 | NUAK1 | 2.23794049 |
| 18 | BCKDK | 2.21706557 |
| 19 | PNCK | 2.15562560 |
| 20 | MAP2K4 | 2.12442946 |
| 21 | CASK | 2.09809814 |
| 22 | RIPK4 | 2.04239794 |
| 23 | NTRK2 | 2.03335217 |
| 24 | MINK1 | 2.00299392 |
| 25 | MARK1 | 1.99309086 |
| 26 | DAPK2 | 1.98236060 |
| 27 | LATS2 | 1.94609558 |
| 28 | KSR2 | 1.94092671 |
| 29 | WEE1 | 1.91744408 |
| 30 | PLK3 | 1.90657208 |
| 31 | TLK1 | 1.90546209 |
| 32 | MUSK | 1.88064663 |
| 33 | TRIM28 | 1.83695140 |
| 34 | TTK | 1.78863135 |
| 35 | TSSK6 | 1.76635321 |
| 36 | MST4 | 1.75858130 |
| 37 | PBK | 1.75124731 |
| 38 | NME2 | 1.74627470 |
| 39 | PAK6 | 1.73119834 |
| 40 | MAP4K2 | 1.70791417 |
| 41 | MAPK13 | 1.68625324 |
| 42 | NEK1 | 1.68076200 |
| 43 | EIF2AK1 | 1.68000386 |
| 44 | TESK2 | 1.61682028 |
| 45 | NTRK1 | 1.56599952 |
| 46 | CDK19 | 1.56099259 |
| 47 | MAP3K6 | 1.55659344 |
| 48 | PLK4 | 1.44261894 |
| 49 | CCNB1 | 1.43428875 |
| 50 | WNK3 | 1.41681612 |
| 51 | MAP3K13 | 1.40775262 |
| 52 | PRKD3 | 1.39457715 |
| 53 | CSNK1G3 | 1.35339301 |
| 54 | BMPR1B | 1.33247036 |
| 55 | GRK5 | 1.32485189 |
| 56 | KDR | 1.32208683 |
| 57 | NME1 | 1.32125263 |
| 58 | PLK1 | 1.31495472 |
| 59 | PDK2 | 1.30148770 |
| 60 | CHEK2 | 1.27682758 |
| 61 | STK38 | 1.25696639 |
| 62 | CAMK2A | 1.23946357 |
| 63 | CDK5 | 1.22302855 |
| 64 | DYRK2 | 1.21840004 |
| 65 | PLK2 | 1.20275796 |
| 66 | EIF2AK3 | 1.20106379 |
| 67 | RAF1 | 1.18458204 |
| 68 | FES | 1.16743291 |
| 69 | CSNK1G1 | 1.16060282 |
| 70 | LIMK1 | 1.14652627 |
| 71 | PHKG1 | 1.13014682 |
| 72 | PHKG2 | 1.13014682 |
| 73 | AURKB | 1.12349959 |
| 74 | BRSK2 | 1.12232206 |
| 75 | MKNK1 | 1.12158738 |
| 76 | DAPK1 | 1.10658442 |
| 77 | ATR | 1.10140346 |
| 78 | PINK1 | 1.06480301 |
| 79 | OXSR1 | 1.03381029 |
| 80 | BMPR2 | 1.03040639 |
| 81 | MKNK2 | 1.01441526 |
| 82 | AURKA | 1.01078941 |
| 83 | TYRO3 | 1.00743672 |
| 84 | LMTK2 | 0.98748512 |
| 85 | KSR1 | 0.98611462 |
| 86 | BRAF | 0.98324550 |
| 87 | MAPKAPK5 | 0.97624626 |
| 88 | UHMK1 | 0.94618785 |
| 89 | FGR | 0.91110531 |
| 90 | PAK3 | 0.90832925 |
| 91 | STK11 | 0.89075224 |
| 92 | CDK8 | 0.88215746 |
| 93 | GRK7 | 0.87465427 |
| 94 | DMPK | 0.86772946 |
| 95 | MYLK | 0.84395878 |
| 96 | BRSK1 | 0.84386351 |
| 97 | PRKCG | 0.83910660 |
| 98 | CSNK1A1L | 0.80986184 |
| 99 | PIM2 | 0.80766115 |
| 100 | RPS6KA5 | 0.79102591 |
| 101 | EIF2AK2 | 0.78089011 |
| 102 | PTK2B | 0.77463669 |
| 103 | SIK2 | 0.75847922 |
| 104 | CDC42BPA | 0.75034809 |
| 105 | SGK223 | 0.74884712 |
| 106 | SGK494 | 0.74884712 |
| 107 | STK4 | 0.72061920 |
| 108 | GRK1 | 0.69809338 |
| 109 | CAMK1 | 0.69231081 |
| 110 | CDK15 | 0.67409275 |
| 111 | STK39 | 0.67328537 |
| 112 | CDK18 | 0.66534611 |
| 113 | ROCK2 | 0.65856479 |
| 114 | CAMK2D | 0.65798734 |
| 115 | CAMKK1 | 0.64419449 |
| 116 | FRK | 0.63886732 |
| 117 | TNK2 | 0.62375092 |
| 118 | CSNK2A1 | 0.62345695 |
| 119 | PASK | 0.62300284 |
| 120 | DAPK3 | 0.62140633 |
| 121 | CAMK2B | 0.60941942 |
| 122 | CSNK1G2 | 0.60391357 |
| 123 | CSNK2A2 | 0.60300198 |
| 124 | SGK1 | 0.60298319 |
| 125 | CDK14 | 0.60177840 |
| 126 | NEK2 | 0.59649036 |
| 127 | CDK11A | 0.58595854 |
| 128 | PRKCE | 0.57595037 |
| 129 | SGK2 | 0.56777955 |
| 130 | PKN1 | 0.56480308 |
| 131 | ERBB4 | 0.56181583 |
| 132 | CDK7 | 0.55701191 |
| 133 | CAMK1G | 0.53767339 |
| 134 | CHEK1 | 0.53602491 |
| 135 | DYRK1A | 0.53465305 |
| 136 | ATM | 0.52025414 |
| 137 | INSRR | 0.52021426 |
| 138 | STK38L | 0.51833470 |
| 139 | TAOK1 | 0.51508646 |
| 140 | ILK | 0.49874943 |
| 141 | PRPF4B | 0.47654445 |
| 142 | RET | 0.46918684 |
| 143 | PRKD2 | 0.46882266 |
| 144 | MOS | 0.46875854 |
| 145 | TESK1 | 0.46762124 |
| 146 | MARK2 | 0.45033514 |
| 147 | RPS6KA3 | 0.44093278 |
| 148 | PAK1 | 0.43966871 |
| 149 | ADRBK2 | 0.43371265 |
| 150 | CAMK2G | 0.43306535 |
| 151 | WNK1 | 0.42935080 |
| 152 | TAOK3 | 0.42796040 |
| 153 | PRKACA | 0.42510777 |
| 154 | ROCK1 | 0.42031944 |
| 155 | PRKCI | 0.41810577 |
| 156 | CSNK1E | 0.41702252 |
| 157 | PRKCH | 0.41139904 |
| 158 | MAP3K1 | 0.40362726 |
| 159 | PRKG1 | 0.40004909 |
| 160 | CDK3 | 0.39326908 |
| 161 | MAPK10 | 0.38951635 |
| 162 | DYRK3 | 0.38798294 |
| 163 | ADRBK1 | 0.36492559 |
| 164 | WNK4 | 0.36336717 |
| 165 | CSNK1A1 | 0.34532236 |
| 166 | ABL2 | 0.33052318 |
| 167 | BCR | 0.32869656 |
| 168 | RPS6KA4 | 0.32811334 |
| 169 | SMG1 | 0.30073145 |
| 170 | CDK1 | 0.26454706 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.08079911 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 4.02548160 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.49650514 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.39238654 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 3.23248567 |
| 6 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.08280895 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.85013964 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.84014728 |
| 9 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.83635525 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.76662511 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.67590880 |
| 12 | Olfactory transduction_Homo sapiens_hsa04740 | 2.64224060 |
| 13 | GABAergic synapse_Homo sapiens_hsa04727 | 2.61335226 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.54712340 |
| 15 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.50529439 |
| 16 | Morphine addiction_Homo sapiens_hsa05032 | 2.42094019 |
| 17 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.39427067 |
| 18 | Circadian entrainment_Homo sapiens_hsa04713 | 2.37747926 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 2.35981709 |
| 20 | Long-term potentiation_Homo sapiens_hsa04720 | 2.35605171 |
| 21 | Base excision repair_Homo sapiens_hsa03410 | 2.29715938 |
| 22 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.23037645 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 2.13878366 |
| 24 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.03137805 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.00814809 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.99546632 |
| 27 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.99373376 |
| 28 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.99169563 |
| 29 | Taste transduction_Homo sapiens_hsa04742 | 1.98066193 |
| 30 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.92138640 |
| 31 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.90233530 |
| 32 | Salivary secretion_Homo sapiens_hsa04970 | 1.85992608 |
| 33 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.82601193 |
| 34 | Spliceosome_Homo sapiens_hsa03040 | 1.81791009 |
| 35 | Insulin secretion_Homo sapiens_hsa04911 | 1.80564879 |
| 36 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.72945014 |
| 37 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.72147049 |
| 38 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.71572148 |
| 39 | Renin secretion_Homo sapiens_hsa04924 | 1.66857511 |
| 40 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.63205602 |
| 41 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.62828004 |
| 42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.62446033 |
| 43 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.62347291 |
| 44 | Long-term depression_Homo sapiens_hsa04730 | 1.58006262 |
| 45 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.58003552 |
| 46 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.57309163 |
| 47 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.56616025 |
| 48 | RNA transport_Homo sapiens_hsa03013 | 1.53045110 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50669781 |
| 50 | Cocaine addiction_Homo sapiens_hsa05030 | 1.47373658 |
| 51 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.46574277 |
| 52 | Sulfur relay system_Homo sapiens_hsa04122 | 1.44647080 |
| 53 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.44639829 |
| 54 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.43958217 |
| 55 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.40438270 |
| 56 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.40181804 |
| 57 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.39158053 |
| 58 | RNA degradation_Homo sapiens_hsa03018 | 1.39067942 |
| 59 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.38374232 |
| 60 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.37224532 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.36666021 |
| 62 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.36163062 |
| 63 | Purine metabolism_Homo sapiens_hsa00230 | 1.32139105 |
| 64 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.31211501 |
| 65 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.26028555 |
| 66 | Phototransduction_Homo sapiens_hsa04744 | 1.24487460 |
| 67 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.18272640 |
| 68 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.17280138 |
| 69 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.14797915 |
| 70 | Gap junction_Homo sapiens_hsa04540 | 1.14654003 |
| 71 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.13923706 |
| 72 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.13457814 |
| 73 | Cell cycle_Homo sapiens_hsa04110 | 1.11680021 |
| 74 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.04015523 |
| 75 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.01806467 |
| 76 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.01745221 |
| 77 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.01500785 |
| 78 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.00962508 |
| 79 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.99485532 |
| 80 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.98947789 |
| 81 | Peroxisome_Homo sapiens_hsa04146 | 0.95428670 |
| 82 | Melanogenesis_Homo sapiens_hsa04916 | 0.95293546 |
| 83 | Carbon metabolism_Homo sapiens_hsa01200 | 0.92532273 |
| 84 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92279415 |
| 85 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.91345551 |
| 86 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.90822268 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88083265 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85009602 |
| 89 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.79025571 |
| 90 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.78398543 |
| 91 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.75943491 |
| 92 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.75475611 |
| 93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.75054320 |
| 94 | Axon guidance_Homo sapiens_hsa04360 | 0.74206175 |
| 95 | Glioma_Homo sapiens_hsa05214 | 0.74035106 |
| 96 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.73415108 |
| 97 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.73036525 |
| 98 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.71498346 |
| 99 | Circadian rhythm_Homo sapiens_hsa04710 | 0.69967307 |
| 100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.67975867 |
| 101 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.67938958 |
| 102 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.64464522 |
| 103 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.61213756 |
| 104 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60669498 |
| 105 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.60617460 |
| 106 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.59290044 |
| 107 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.57859230 |
| 108 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.57501458 |
| 109 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.57353118 |
| 110 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.56621568 |
| 111 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56451056 |
| 112 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.56129369 |
| 113 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.55079041 |
| 114 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.53762423 |
| 115 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.52563787 |
| 116 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.52259317 |
| 117 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.51390303 |
| 118 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.51007003 |
| 119 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.49413794 |
| 120 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.47826337 |
| 121 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.47560759 |
| 122 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.47301543 |
| 123 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.46311807 |
| 124 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.46229949 |
| 125 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.44986462 |
| 126 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44306980 |
| 127 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.44273462 |
| 128 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44068227 |
| 129 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42664579 |
| 130 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.42192050 |
| 131 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.42029822 |
| 132 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.41862680 |
| 133 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41579320 |
| 134 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41063891 |
| 135 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.40882445 |
| 136 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.40617250 |
| 137 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40496978 |
| 138 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.39328108 |
| 139 | Alcoholism_Homo sapiens_hsa05034 | 0.38815064 |
| 140 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38027252 |
| 141 | RNA polymerase_Homo sapiens_hsa03020 | 0.37730494 |
| 142 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36642931 |
| 143 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.36175830 |
| 144 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.35763022 |
| 145 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35408216 |
| 146 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.34622411 |
| 147 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.33548684 |
| 148 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.33097748 |
| 149 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31001542 |
| 150 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30618335 |
| 151 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.30319246 |
| 152 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.29483192 |
| 153 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28308083 |
| 154 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.28090007 |
| 155 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.27621550 |
| 156 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.26662097 |
| 157 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.25709529 |
| 158 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.25135211 |
| 159 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.24768216 |
| 160 | Prion diseases_Homo sapiens_hsa05020 | 0.24429380 |
| 161 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24323955 |
| 162 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.24125656 |
| 163 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23802616 |
| 164 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.23618206 |
| 165 | Retinol metabolism_Homo sapiens_hsa00830 | 0.22975529 |
| 166 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.22845162 |
| 167 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.22541158 |
| 168 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.21939542 |
| 169 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.21761676 |
| 170 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.19491007 |
| 171 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.17876997 |
| 172 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.17615528 |
| 173 | Tight junction_Homo sapiens_hsa04530 | 0.16206369 |
| 174 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.16141225 |
| 175 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.14970140 |
| 176 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.14462337 |
| 177 | Basal transcription factors_Homo sapiens_hsa03022 | 0.12776650 |
| 178 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.12263323 |
| 179 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.11359407 |

