ELP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66885192
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.18813068
3vocalization behavior (GO:0071625)5.09963143
4synaptic vesicle exocytosis (GO:0016079)4.97881734
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.92703642
6neuronal action potential propagation (GO:0019227)4.81472279
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75689411
8neuron cell-cell adhesion (GO:0007158)4.74630983
9proteasome assembly (GO:0043248)4.63166110
10protein complex biogenesis (GO:0070271)4.50748170
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49313674
12protein localization to synapse (GO:0035418)4.48018195
13mitochondrial respiratory chain complex assembly (GO:0033108)4.42934874
14glutamate secretion (GO:0014047)4.42820285
15locomotory exploration behavior (GO:0035641)4.24741369
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21102056
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.20680562
18NADH dehydrogenase complex assembly (GO:0010257)4.20680562
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20680562
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16554758
21regulation of synaptic vesicle exocytosis (GO:2000300)4.15690932
22synaptic vesicle maturation (GO:0016188)4.12079238
23regulation of glutamate receptor signaling pathway (GO:1900449)4.08406796
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.07169566
25regulation of protein kinase A signaling (GO:0010738)4.05050554
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.03456310
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98160159
28regulation of mitochondrial translation (GO:0070129)3.96908379
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.87402741
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86305838
31ATP synthesis coupled proton transport (GO:0015986)3.86305838
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85569655
33protein neddylation (GO:0045116)3.85082206
34regulation of synaptic vesicle transport (GO:1902803)3.84483057
35neurotransmitter secretion (GO:0007269)3.82798754
36transmission of nerve impulse (GO:0019226)3.82313649
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.82215784
38termination of RNA polymerase III transcription (GO:0006386)3.82215784
39glutamate receptor signaling pathway (GO:0007215)3.78114232
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76887802
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70625920
42neuron-neuron synaptic transmission (GO:0007270)3.70383969
43chaperone-mediated protein transport (GO:0072321)3.69386215
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68007342
45rRNA modification (GO:0000154)3.67986187
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.66740333
47negative regulation of ligase activity (GO:0051352)3.66478772
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66478772
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66167926
50righting reflex (GO:0060013)3.65710969
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65622395
52regulation of neuronal synaptic plasticity (GO:0048168)3.64649884
53response to histamine (GO:0034776)3.64390439
54chromatin remodeling at centromere (GO:0031055)3.62789827
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62205299
56cullin deneddylation (GO:0010388)3.61965582
57ribosomal small subunit assembly (GO:0000028)3.56893548
58CENP-A containing nucleosome assembly (GO:0034080)3.55751632
59exploration behavior (GO:0035640)3.55499628
60DNA strand elongation involved in DNA replication (GO:0006271)3.55074817
61synaptic transmission, glutamatergic (GO:0035249)3.54852179
62neuron recognition (GO:0008038)3.52870359
63regulation of postsynaptic membrane potential (GO:0060078)3.52672195
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51171670
65neuromuscular process controlling posture (GO:0050884)3.48180987
66pseudouridine synthesis (GO:0001522)3.46926733
67respiratory electron transport chain (GO:0022904)3.46746431
68respiratory chain complex IV assembly (GO:0008535)3.46210342
69establishment of integrated proviral latency (GO:0075713)3.45208691
70regulation of cellular amino acid metabolic process (GO:0006521)3.45118982
71dendritic spine morphogenesis (GO:0060997)3.44314351
72regulation of synapse structural plasticity (GO:0051823)3.43629611
73telomere maintenance via semi-conservative replication (GO:0032201)3.42982930
74DNA damage response, detection of DNA damage (GO:0042769)3.42583493
75protein targeting to mitochondrion (GO:0006626)3.40239739
76layer formation in cerebral cortex (GO:0021819)3.39493597
77DNA strand elongation (GO:0022616)3.38241692
78regulation of voltage-gated calcium channel activity (GO:1901385)3.37713400
79electron transport chain (GO:0022900)3.37585654
80neurotransmitter transport (GO:0006836)3.36932656
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36729567
82protein deneddylation (GO:0000338)3.36047066
83oxidative phosphorylation (GO:0006119)3.36005347
84positive regulation of membrane potential (GO:0045838)3.35586579
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34482190
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34279974
87synaptic vesicle endocytosis (GO:0048488)3.33581972
88cytochrome complex assembly (GO:0017004)3.33449746
89establishment of protein localization to mitochondrion (GO:0072655)3.33138786
90presynaptic membrane assembly (GO:0097105)3.33056415
91detection of calcium ion (GO:0005513)3.32531189
92maturation of SSU-rRNA (GO:0030490)3.32180347
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30934974
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30934974
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30934974
96purine nucleobase biosynthetic process (GO:0009113)3.29947948
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.29708045
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29672191
99membrane hyperpolarization (GO:0060081)3.29581058
100replication fork processing (GO:0031297)3.29322257
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28822916
102intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27989933
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27989933
104cotranslational protein targeting to membrane (GO:0006613)3.27608318
105regulation of vesicle fusion (GO:0031338)3.26865788
106spliceosomal snRNP assembly (GO:0000387)3.26852862
107viral transcription (GO:0019083)3.26603278
108nucleobase biosynthetic process (GO:0046112)3.26082095
109ribosomal large subunit biogenesis (GO:0042273)3.26029989
110inner mitochondrial membrane organization (GO:0007007)3.25193130
111positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.24932978
112DNA replication checkpoint (GO:0000076)3.23072529
113translational termination (GO:0006415)3.21233509
114signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21043151
115signal transduction involved in DNA damage checkpoint (GO:0072422)3.21043151
116protein targeting to ER (GO:0045047)3.20988346
117G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.19550687
118neurotransmitter-gated ion channel clustering (GO:0072578)3.19053989
119long-term memory (GO:0007616)3.18534273
120signal transduction involved in cell cycle checkpoint (GO:0072395)3.17330571
121translation (GO:0006412)3.17167291
122water-soluble vitamin biosynthetic process (GO:0042364)3.16843899
123protein localization to mitochondrion (GO:0070585)3.16738459
124presynaptic membrane organization (GO:0097090)3.16316056
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15851296
126regulation of neurotransmitter levels (GO:0001505)3.15548049
127activation of protein kinase A activity (GO:0034199)3.14356055
128positive regulation of ligase activity (GO:0051351)3.13869824
129cerebellar Purkinje cell differentiation (GO:0021702)3.13458526
130GTP biosynthetic process (GO:0006183)3.13307021
131behavioral defense response (GO:0002209)3.11895728
132behavioral fear response (GO:0001662)3.11895728
133cellular component biogenesis (GO:0044085)3.10293977
134regulation of dendritic spine morphogenesis (GO:0061001)3.09696771
135striatum development (GO:0021756)3.09670429
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08718156
137RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08718156
138protein localization to endoplasmic reticulum (GO:0070972)3.07347511
139ribosomal small subunit biogenesis (GO:0042274)3.07327514
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07167157
141proline transport (GO:0015824)3.06852999
142purine nucleoside triphosphate biosynthetic process (GO:0009145)3.06273822
143regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.06257357
144establishment of protein localization to endoplasmic reticulum (GO:0072599)3.03244064
145transcription-coupled nucleotide-excision repair (GO:0006283)3.03160346
146regulation of synaptic transmission, glutamatergic (GO:0051966)3.02805609
147purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02115957
148base-excision repair, AP site formation (GO:0006285)3.01913008
149peptidyl-histidine modification (GO:0018202)3.00674460
150regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00183239
151positive regulation of meiosis (GO:0045836)2.99802595
152ATP biosynthetic process (GO:0006754)2.98581937
153membrane depolarization (GO:0051899)2.98455227
154regulation of neurotransmitter secretion (GO:0046928)2.98285634
155translational elongation (GO:0006414)2.97732350
156regulation of ubiquitin-protein transferase activity (GO:0051438)2.97442028
157axonal fasciculation (GO:0007413)2.97294940
158pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96810011
159postsynaptic membrane organization (GO:0001941)2.96056580
160fear response (GO:0042596)2.95915675
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.95765675
162mannosylation (GO:0097502)2.93466605
163regulation of glutamate secretion (GO:0014048)2.93289706
164pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92866078
165rRNA processing (GO:0006364)2.92190525
166oxygen transport (GO:0015671)2.92076923
167behavioral response to cocaine (GO:0048148)2.92073754
168establishment of viral latency (GO:0019043)2.91603497
169UTP biosynthetic process (GO:0006228)2.91083242
170membrane depolarization during action potential (GO:0086010)2.89870661
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89865198
172mitotic recombination (GO:0006312)2.89567481
173kinetochore assembly (GO:0051382)2.89118766
174telomere maintenance via recombination (GO:0000722)2.88357388
175maturation of 5.8S rRNA (GO:0000460)2.87889361
176protein localization to kinetochore (GO:0034501)2.87711030
177neuronal ion channel clustering (GO:0045161)2.86922008
178regulation of synaptic plasticity (GO:0048167)2.85603989
179gamma-aminobutyric acid transport (GO:0015812)2.84785422
180auditory behavior (GO:0031223)2.84718602
181startle response (GO:0001964)2.84395080
182adult walking behavior (GO:0007628)2.84253994
183regulation of neurotransmitter transport (GO:0051588)2.83368888
184positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80285887
185synaptic transmission (GO:0007268)2.80260043
186positive regulation of potassium ion transmembrane transport (GO:1901381)2.78252222
187positive regulation of synaptic transmission, GABAergic (GO:0032230)2.78151204
188negative regulation of dendrite morphogenesis (GO:0050774)2.77926623
189intraspecies interaction between organisms (GO:0051703)2.77676181
190social behavior (GO:0035176)2.77676181
191neurotransmitter catabolic process (GO:0042135)2.77619219
192cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77334452
193positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.76656492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38477650
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.54200481
3E2F7_22180533_ChIP-Seq_HELA_Human4.93538016
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.56041485
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.22747073
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.96032247
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.66700562
8GBX2_23144817_ChIP-Seq_PC3_Human3.48327164
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.43396152
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42168324
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31913005
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23841984
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17261786
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16091702
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.04514196
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99355910
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92859947
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83303340
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82390394
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78257119
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66995360
22TAF15_26573619_Chip-Seq_HEK293_Human2.63524794
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60761667
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60761667
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59902688
26VDR_23849224_ChIP-Seq_CD4+_Human2.59137032
27ELK1_19687146_ChIP-ChIP_HELA_Human2.59003466
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.57765058
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57657532
30REST_21632747_ChIP-Seq_MESCs_Mouse2.51680382
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.47347840
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45818781
33FOXP3_21729870_ChIP-Seq_TREG_Human2.44103037
34SRF_21415370_ChIP-Seq_HL-1_Mouse2.43353737
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41606709
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36783271
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32941205
38MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31666397
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26674308
40RARB_27405468_Chip-Seq_BRAIN_Mouse2.24995327
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24115208
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21704923
43XRN2_22483619_ChIP-Seq_HELA_Human2.21673016
44MYC_19079543_ChIP-ChIP_MESCs_Mouse2.19720722
45DCP1A_22483619_ChIP-Seq_HELA_Human2.18322857
46E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17931691
47CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14179509
48TTF2_22483619_ChIP-Seq_HELA_Human2.13485783
49REST_18959480_ChIP-ChIP_MESCs_Mouse2.11879110
50EED_16625203_ChIP-ChIP_MESCs_Mouse2.10866246
51GABP_19822575_ChIP-Seq_HepG2_Human2.09775256
52DROSHA_22980978_ChIP-Seq_HELA_Human2.08664344
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05919260
54RNF2_27304074_Chip-Seq_ESCs_Mouse2.05210790
55EZH2_27294783_Chip-Seq_ESCs_Mouse2.03646172
56SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01844554
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.94383509
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93414785
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.87971067
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87816165
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86778218
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86558404
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.86066176
64AR_21572438_ChIP-Seq_LNCaP_Human1.85702967
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84175074
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79567772
67MYC_18940864_ChIP-ChIP_HL60_Human1.77733435
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76653531
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76580576
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75860584
71SMAD4_21799915_ChIP-Seq_A2780_Human1.74413791
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72840012
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72461799
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72095784
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71648154
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68226387
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68222286
78FUS_26573619_Chip-Seq_HEK293_Human1.63280897
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63167823
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61848430
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59952494
82P300_19829295_ChIP-Seq_ESCs_Human1.55290360
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54155090
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53262561
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.50813353
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50148146
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48935502
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48909025
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.45439703
90RNF2_27304074_Chip-Seq_NSC_Mouse1.39067406
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38916370
92KDM5A_27292631_Chip-Seq_BREAST_Human1.37781335
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34576498
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33667056
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.31429170
96IGF1R_20145208_ChIP-Seq_DFB_Human1.30871675
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30172158
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29025984
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.27896144
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27308837
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27118007
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26937410
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23789008
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22655409
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21983134
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20892544
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.20534718
108STAT3_23295773_ChIP-Seq_U87_Human1.20287288
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20158133
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20120762
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18271560
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17120613
113ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17038096
114TCF4_23295773_ChIP-Seq_U87_Human1.16101477
115AR_25329375_ChIP-Seq_VCAP_Human1.16009825
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.15446502
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14245708
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13540884
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13411439
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13329081
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13094900
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12871320
123EWS_26573619_Chip-Seq_HEK293_Human1.12750440
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12111689
125HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11681472
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.10890629
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10709039
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.10692665
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09210797
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08298824
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07730887
132RUNX2_22187159_ChIP-Seq_PCA_Human1.07669625
133ZNF274_21170338_ChIP-Seq_K562_Hela1.07303430
134IRF1_19129219_ChIP-ChIP_H3396_Human1.07233358
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.07060941
136P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06574456
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.06488721
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.06244930
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06129259
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05927360
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.05649141
142VDR_22108803_ChIP-Seq_LS180_Human1.05236327
143ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05092008
144ER_23166858_ChIP-Seq_MCF-7_Human1.04863903
145ELK1_22589737_ChIP-Seq_MCF10A_Human1.04854500
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04755547
147JUN_21703547_ChIP-Seq_K562_Human1.04553194
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03184197
149ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02703722
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02169915
151AR_19668381_ChIP-Seq_PC3_Human1.02006792
152PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01896091
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01802933
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01802933
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99892906
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98831727
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98732251
158E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97436085
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97252712
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96794979
161NANOG_16153702_ChIP-ChIP_HESCs_Human0.96773664
162CIITA_25753668_ChIP-Seq_RAJI_Human0.94998362
163EP300_21415370_ChIP-Seq_HL-1_Mouse0.94993131
164CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94108149
165AR_21909140_ChIP-Seq_LNCAP_Human0.92674947
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.90176680
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89840181
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89383555
169TP53_22573176_ChIP-Seq_HFKS_Human0.89212612
170E2F1_18555785_Chip-Seq_ESCs_Mouse0.88275856
171YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87836690
172NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87667384
173HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86780976
174TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85921899
175KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85603057
176KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85530911
177MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85374824
178MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85290491
179SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85067424
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83889472
181WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83430149
182SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82280491
183PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80955922
184FOXP1_21924763_ChIP-Seq_HESCs_Human0.80541282
185TP63_19390658_ChIP-ChIP_HaCaT_Human0.78602092
186CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78358894
187SOX17_20123909_ChIP-Seq_XEN_Mouse0.77924891
188FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73627259
189NOTCH1_21737748_ChIP-Seq_TLL_Human0.73401616
190TFEB_21752829_ChIP-Seq_HELA_Human0.69583295
191TBX5_21415370_ChIP-Seq_HL-1_Mouse0.66899705
192EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66102802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.42647350
2MP0004859_abnormal_synaptic_plasticity4.94569318
3MP0008058_abnormal_DNA_repair3.89983122
4MP0003635_abnormal_synaptic_transmissio3.59172245
5MP0010094_abnormal_chromosome_stability3.54194296
6MP0002837_dystrophic_cardiac_calcinosis3.51273190
7MP0003693_abnormal_embryo_hatching3.49761197
8MP0009745_abnormal_behavioral_response3.10879783
9MP0004270_analgesia3.10712525
10MP0001968_abnormal_touch/_nociception2.95882963
11MP0002064_seizures2.89468694
12MP0009046_muscle_twitch2.88481264
13MP0001529_abnormal_vocalization2.86484424
14MP0002063_abnormal_learning/memory/cond2.81826864
15MP0004957_abnormal_blastocyst_morpholog2.73829757
16MP0003111_abnormal_nucleus_morphology2.70317776
17MP0003806_abnormal_nucleotide_metabolis2.64061697
18MP0003786_premature_aging2.62350767
19MP0000372_irregular_coat_pigmentation2.61973743
20MP0005423_abnormal_somatic_nervous2.59364695
21MP0002572_abnormal_emotion/affect_behav2.54418933
22MP0003186_abnormal_redox_activity2.50087077
23MP0002736_abnormal_nociception_after2.45008098
24MP0001486_abnormal_startle_reflex2.44938596
25MP0002272_abnormal_nervous_system2.44352233
26MP0008007_abnormal_cellular_replicative2.39877235
27MP0003646_muscle_fatigue2.38662861
28MP0001440_abnormal_grooming_behavior2.38428955
29MP0002734_abnormal_mechanical_nocicepti2.35570306
30MP0000751_myopathy2.35545691
31MP0003077_abnormal_cell_cycle2.35529693
32MP0002822_catalepsy2.34685413
33MP0008932_abnormal_embryonic_tissue2.30785400
34MP0003718_maternal_effect2.25061869
35MP0006036_abnormal_mitochondrial_physio2.24877143
36MP0006276_abnormal_autonomic_nervous2.23178905
37MP0002938_white_spotting2.22695720
38MP0001501_abnormal_sleep_pattern2.13782376
39MP0003136_yellow_coat_color1.99754966
40MP0004147_increased_porphyrin_level1.99279387
41MP0005386_behavior/neurological_phenoty1.94705602
42MP0004924_abnormal_behavior1.94705602
43MP0002067_abnormal_sensory_capabilities1.88951178
44MP0009697_abnormal_copulation1.86741159
45MP0001970_abnormal_pain_threshold1.82179830
46MP0001905_abnormal_dopamine_level1.81441046
47MP0004215_abnormal_myocardial_fiber1.75905555
48MP0005646_abnormal_pituitary_gland1.69088681
49MP0002733_abnormal_thermal_nociception1.68140348
50MP0002735_abnormal_chemical_nociception1.61930474
51MP0008995_early_reproductive_senescence1.61218365
52MP0004142_abnormal_muscle_tone1.60576043
53MP0002184_abnormal_innervation1.58007283
54MP0008789_abnormal_olfactory_epithelium1.56886172
55MP0002557_abnormal_social/conspecific_i1.51886941
56MP0000778_abnormal_nervous_system1.50997011
57MP0008569_lethality_at_weaning1.46823962
58MP0001293_anophthalmia1.45736932
59MP0010030_abnormal_orbit_morphology1.44176188
60MP0004145_abnormal_muscle_electrophysio1.42930455
61MP0002160_abnormal_reproductive_system1.39897448
62MP0003329_amyloid_beta_deposits1.38265097
63MP0000358_abnormal_cell_content/1.38117459
64MP0003787_abnormal_imprinting1.37010950
65MP0001502_abnormal_circadian_rhythm1.34062043
66MP0009379_abnormal_foot_pigmentation1.33201689
67MP0004036_abnormal_muscle_relaxation1.32228429
68MP0002066_abnormal_motor_capabilities/c1.29671804
69MP0003137_abnormal_impulse_conducting1.28570408
70MP0006292_abnormal_olfactory_placode1.28400522
71MP0005253_abnormal_eye_physiology1.28207084
72MP0002653_abnormal_ependyma_morphology1.28003366
73MP0004084_abnormal_cardiac_muscle1.26223039
74MP0005084_abnormal_gallbladder_morpholo1.25992012
75MP0000955_abnormal_spinal_cord1.25357843
76MP0002882_abnormal_neuron_morphology1.24463027
77MP0002234_abnormal_pharynx_morphology1.24131397
78MP0002210_abnormal_sex_determination1.23620842
79MP0003011_delayed_dark_adaptation1.22970333
80MP0001188_hyperpigmentation1.20882846
81MP0001984_abnormal_olfaction1.19662757
82MP0004811_abnormal_neuron_physiology1.17925286
83MP0005075_abnormal_melanosome_morpholog1.17079148
84MP0004085_abnormal_heartbeat1.14459959
85MP0008877_abnormal_DNA_methylation1.13527395
86MP0002909_abnormal_adrenal_gland1.08847903
87MP0005171_absent_coat_pigmentation1.08470448
88MP0003122_maternal_imprinting1.08321217
89MP0001764_abnormal_homeostasis1.08074382
90MP0003567_abnormal_fetal_cardiomyocyte1.07490252
91MP0005551_abnormal_eye_electrophysiolog1.07219424
92MP0003879_abnormal_hair_cell1.06735554
93MP0008057_abnormal_DNA_replication1.06452632
94MP0001929_abnormal_gametogenesis1.04258396
95MP0005389_reproductive_system_phenotype1.03687483
96MP0002102_abnormal_ear_morphology1.01998781
97MP0003195_calcinosis1.01002991
98MP0008875_abnormal_xenobiotic_pharmacok1.00920159
99MP0002152_abnormal_brain_morphology0.99635562
100MP0000653_abnormal_sex_gland0.96314290
101MP0006072_abnormal_retinal_apoptosis0.96226245
102MP0001145_abnormal_male_reproductive0.96074959
103MP0004484_altered_response_of0.96033811
104MP0005408_hypopigmentation0.95347696
105MP0008872_abnormal_physiological_respon0.95215022
106MP0005645_abnormal_hypothalamus_physiol0.94764246
107MP0002090_abnormal_vision0.94694703
108MP0002095_abnormal_skin_pigmentation0.94477348
109MP0004742_abnormal_vestibular_system0.92182832
110MP0000049_abnormal_middle_ear0.91852597
111MP0005409_darkened_coat_color0.91240667
112MP0000350_abnormal_cell_proliferation0.90545147
113MP0005379_endocrine/exocrine_gland_phen0.89282386
114MP0010386_abnormal_urinary_bladder0.88955665
115MP0002229_neurodegeneration0.87841577
116MP0003631_nervous_system_phenotype0.86999670
117MP0004133_heterotaxia0.86791433
118MP0005330_cardiomyopathy0.85768378
119MP0003315_abnormal_perineum_morphology0.85358396
120MP0003123_paternal_imprinting0.85325105
121MP0001485_abnormal_pinna_reflex0.84598349
122MP0005535_abnormal_body_temperature0.84081022
123MP0005623_abnormal_meninges_morphology0.84054575
124MP0003633_abnormal_nervous_system0.83322309
125MP0009780_abnormal_chondrocyte_physiolo0.82098272
126MP0005391_vision/eye_phenotype0.81893239
127MP0005332_abnormal_amino_acid0.81788829
128MP0002752_abnormal_somatic_nervous0.81502759
129MP0002638_abnormal_pupillary_reflex0.81053010
130MP0000749_muscle_degeneration0.80981007
131MP0002751_abnormal_autonomic_nervous0.80496985
132MP0001697_abnormal_embryo_size0.80357309
133MP0003119_abnormal_digestive_system0.80144268
134MP0003937_abnormal_limbs/digits/tail_de0.79606060
135MP0003121_genomic_imprinting0.79583268
136MP0000313_abnormal_cell_death0.79271101
137MP0005620_abnormal_muscle_contractility0.78739992
138MP0001119_abnormal_female_reproductive0.78549983
139MP0003698_abnormal_male_reproductive0.78082003
140MP0008874_decreased_physiological_sensi0.77990382
141MP0002277_abnormal_respiratory_mucosa0.77865346
142MP0000647_abnormal_sebaceous_gland0.77728315
143MP0001346_abnormal_lacrimal_gland0.77270501
144MP0001730_embryonic_growth_arrest0.77205537
145MP0000631_abnormal_neuroendocrine_gland0.76093782
146MP0000747_muscle_weakness0.75770297
147MP0001286_abnormal_eye_development0.75612206
148MP0002332_abnormal_exercise_endurance0.75249820
149MP0002069_abnormal_eating/drinking_beha0.74576642
150MP0001919_abnormal_reproductive_system0.74291170
151MP0002106_abnormal_muscle_physiology0.73566928
152MP0001963_abnormal_hearing_physiology0.73213271
153MP0003632_abnormal_nervous_system0.72771800
154MP0002972_abnormal_cardiac_muscle0.71338459
155MP0001177_atelectasis0.69662552
156MP0005195_abnormal_posterior_eye0.68598003
157MP0005394_taste/olfaction_phenotype0.68596678
158MP0005499_abnormal_olfactory_system0.68596678
159MP0002282_abnormal_trachea_morphology0.68073592
160MP0006138_congestive_heart_failure0.67621431
161MP0002163_abnormal_gland_morphology0.66088899
162MP0005369_muscle_phenotype0.65976228
163MP0004510_myositis0.63788598
164MP0004858_abnormal_nervous_system0.61274264
165MP0001727_abnormal_embryo_implantation0.60604554
166MP0006035_abnormal_mitochondrial_morpho0.58325638
167MP0001943_abnormal_respiration0.57883281

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.66986143
2Myokymia (HP:0002411)5.77754090
3Focal seizures (HP:0007359)5.26440910
4Atonic seizures (HP:0010819)4.80400912
5Visual hallucinations (HP:0002367)4.51211963
6Febrile seizures (HP:0002373)4.31558439
7Hepatic necrosis (HP:0002605)3.96534709
8Absence seizures (HP:0002121)3.89882080
9Cerebral edema (HP:0002181)3.85385643
10Lipid accumulation in hepatocytes (HP:0006561)3.84463346
11Epileptic encephalopathy (HP:0200134)3.63228857
12Renal Fanconi syndrome (HP:0001994)3.62994882
13Sudden death (HP:0001699)3.55011458
14Dialeptic seizures (HP:0011146)3.54936094
15Acute necrotizing encephalopathy (HP:0006965)3.54156290
16Generalized tonic-clonic seizures (HP:0002069)3.43299291
17Progressive cerebellar ataxia (HP:0002073)3.39739130
18Type I transferrin isoform profile (HP:0003642)3.39190731
19Broad-based gait (HP:0002136)3.34835108
20Progressive macrocephaly (HP:0004481)3.17874408
21Reticulocytopenia (HP:0001896)3.17397923
22Increased serum lactate (HP:0002151)3.16772175
23Abnormal mitochondria in muscle tissue (HP:0008316)3.16268544
24Increased intramyocellular lipid droplets (HP:0012240)3.15525045
25Lactic acidosis (HP:0003128)3.10080107
26Amblyopia (HP:0000646)3.07767100
27Gaze-evoked nystagmus (HP:0000640)3.03872065
283-Methylglutaconic aciduria (HP:0003535)3.03022135
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00309561
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00309561
31Abnormal number of erythroid precursors (HP:0012131)2.98816872
32Mitochondrial inheritance (HP:0001427)2.93159239
33Abnormality of cells of the erythroid lineage (HP:0012130)2.85975059
34Exercise intolerance (HP:0003546)2.84130747
35Abnormal protein glycosylation (HP:0012346)2.82391712
36Abnormal glycosylation (HP:0012345)2.82391712
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.82391712
38Abnormal protein N-linked glycosylation (HP:0012347)2.82391712
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81653016
40Respiratory failure (HP:0002878)2.78779580
41Dysmetria (HP:0001310)2.77071031
42Urinary bladder sphincter dysfunction (HP:0002839)2.74449051
43Anxiety (HP:0000739)2.74052545
44Nuclear cataract (HP:0100018)2.73933689
45Calf muscle hypertrophy (HP:0008981)2.71724859
46Muscle hypertrophy of the lower extremities (HP:0008968)2.70626509
47Action tremor (HP:0002345)2.66637853
48Acute encephalopathy (HP:0006846)2.65273437
49Dysdiadochokinesis (HP:0002075)2.64088683
50Abnormality of midbrain morphology (HP:0002418)2.60005038
51Molar tooth sign on MRI (HP:0002419)2.60005038
52Meckel diverticulum (HP:0002245)2.59184548
53Poor eye contact (HP:0000817)2.59182792
54Fetal akinesia sequence (HP:0001989)2.58733497
55Increased muscle lipid content (HP:0009058)2.56322028
56Leukodystrophy (HP:0002415)2.56043755
57Exertional dyspnea (HP:0002875)2.52454371
58Abnormality of the ileum (HP:0001549)2.52118481
59Respiratory difficulties (HP:0002880)2.50535220
60Reduced antithrombin III activity (HP:0001976)2.50075872
61Zonular cataract (HP:0010920)2.49389853
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.48667716
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48490218
64Abnormality of the labia minora (HP:0012880)2.48388512
65Impaired vibration sensation in the lower limbs (HP:0002166)2.47184021
66Microvesicular hepatic steatosis (HP:0001414)2.45427145
67Colon cancer (HP:0003003)2.44699844
68Ventricular fibrillation (HP:0001663)2.43806827
69Lethargy (HP:0001254)2.42206798
70Atrial fibrillation (HP:0005110)2.41926502
71Increased serum pyruvate (HP:0003542)2.41912108
72Primary atrial arrhythmia (HP:0001692)2.39532734
73Hyperglycinemia (HP:0002154)2.38909348
74Macrocytic anemia (HP:0001972)2.37947914
75Chromsome breakage (HP:0040012)2.35578562
76Increased CSF lactate (HP:0002490)2.34628370
77Myotonia (HP:0002486)2.34546818
78Type 2 muscle fiber atrophy (HP:0003554)2.34257790
79Abnormality of glycolysis (HP:0004366)2.34237766
80Syncope (HP:0001279)2.32673983
81Pancreatic cysts (HP:0001737)2.28795655
82Truncal ataxia (HP:0002078)2.27398850
83Supraventricular tachycardia (HP:0004755)2.27113921
84Impaired social interactions (HP:0000735)2.26709231
85Abnormal social behavior (HP:0012433)2.26709231
86Abnormal eating behavior (HP:0100738)2.25936455
87Bundle branch block (HP:0011710)2.25882634
88Ankle clonus (HP:0011448)2.24375458
89Optic disc pallor (HP:0000543)2.23904947
90Pancytopenia (HP:0001876)2.23640383
91Gait imbalance (HP:0002141)2.23468711
92Testicular atrophy (HP:0000029)2.23224639
93Pancreatic fibrosis (HP:0100732)2.22776789
94Pheochromocytoma (HP:0002666)2.21207608
95Hyperventilation (HP:0002883)2.20955661
96Abnormality of the preputium (HP:0100587)2.18849271
97Abnormality of alanine metabolism (HP:0010916)2.18823409
98Hyperalaninemia (HP:0003348)2.18823409
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18823409
100Congenital primary aphakia (HP:0007707)2.18427202
101Methylmalonic aciduria (HP:0012120)2.18263812
102Hepatocellular necrosis (HP:0001404)2.18224367
103Supraventricular arrhythmia (HP:0005115)2.18071955
104Delusions (HP:0000746)2.16279611
105Hemiparesis (HP:0001269)2.15905813
106Abnormality of the anterior horn cell (HP:0006802)2.15117312
107Degeneration of anterior horn cells (HP:0002398)2.15117312
108Dysmetric saccades (HP:0000641)2.14927889
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14897759
110Prolonged QT interval (HP:0001657)2.14448663
111Depression (HP:0000716)2.14354029
112Progressive inability to walk (HP:0002505)2.13484623
113Abnormality of methionine metabolism (HP:0010901)2.13166533
114Increased hepatocellular lipid droplets (HP:0006565)2.13030807
115Limb dystonia (HP:0002451)2.11903302
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11711925
117Methylmalonic acidemia (HP:0002912)2.11427819
118Supranuclear gaze palsy (HP:0000605)2.11107039
119Muscle fiber splitting (HP:0003555)2.11105944
120Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10865115
121Muscle fiber atrophy (HP:0100295)2.10255661
122Absent/shortened dynein arms (HP:0200106)2.09825437
123Dynein arm defect of respiratory motile cilia (HP:0012255)2.09825437
124Birth length less than 3rd percentile (HP:0003561)2.09645679
125Abnormality of the calf musculature (HP:0001430)2.09195837
126Absent thumb (HP:0009777)2.08712942
127Unsteady gait (HP:0002317)2.07383954
128Genetic anticipation (HP:0003743)2.05428683
129Neurofibrillary tangles (HP:0002185)2.04905271
130Neuroendocrine neoplasm (HP:0100634)2.04836520
131Postural instability (HP:0002172)2.04482984
132Left ventricular hypertrophy (HP:0001712)2.04310929
133Spastic gait (HP:0002064)2.01969335
134CNS demyelination (HP:0007305)2.01681933
135Microretrognathia (HP:0000308)2.01418829
136Abnormal EKG (HP:0003115)2.00676873
137Abnormality of serum amino acid levels (HP:0003112)2.00541019
138Scanning speech (HP:0002168)1.98661616
139Abnormality of renal resorption (HP:0011038)1.98194130
140Cerebral inclusion bodies (HP:0100314)1.98108028
141Aplastic anemia (HP:0001915)1.98007129
142Bradykinesia (HP:0002067)1.97519177
143True hermaphroditism (HP:0010459)1.95527440
144Cerebral hypomyelination (HP:0006808)1.94169991
145Hypoplasia of the pons (HP:0012110)1.93937852
146Sclerocornea (HP:0000647)1.91710495
147Abnormal ciliary motility (HP:0012262)1.91140369
148Incomplete penetrance (HP:0003829)1.90873933
149Epileptiform EEG discharges (HP:0011182)1.88776107
150Urinary urgency (HP:0000012)1.88324004
151Generalized myoclonic seizures (HP:0002123)1.87888354
152Abnormal respiratory motile cilium physiology (HP:0012261)1.87799166
153Rapidly progressive (HP:0003678)1.87759012
154Abnormality of chromosome stability (HP:0003220)1.87324830
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86709283
156Drooling (HP:0002307)1.86448425
157Excessive salivation (HP:0003781)1.86448425
158Impaired vibratory sensation (HP:0002495)1.85760074
159X-linked dominant inheritance (HP:0001423)1.85684495
160Abnormality of urine glucose concentration (HP:0011016)1.85285398
161Glycosuria (HP:0003076)1.85285398
162Medial flaring of the eyebrow (HP:0010747)1.85243985
163EEG with generalized epileptiform discharges (HP:0011198)1.84419599
164Abnormality of the pons (HP:0007361)1.83785933
165Insidious onset (HP:0003587)1.82466918
166Termporal pattern (HP:0011008)1.82466918
167Small intestinal stenosis (HP:0012848)1.82132415
168Duodenal stenosis (HP:0100867)1.82132415
169Impaired smooth pursuit (HP:0007772)1.81954737
170Esotropia (HP:0000565)1.81916955
171Genital tract atresia (HP:0001827)1.80945890
172Emotional lability (HP:0000712)1.80486515
173Absent speech (HP:0001344)1.80299464
174Horseshoe kidney (HP:0000085)1.75493932
175Papilledema (HP:0001085)1.75082619
176Opisthotonus (HP:0002179)1.74957768
177Abnormality of binocular vision (HP:0011514)1.74946729
178Diplopia (HP:0000651)1.74946729
179Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74894240
180Nephronophthisis (HP:0000090)1.74802333
181Polyphagia (HP:0002591)1.74343500
182Pendular nystagmus (HP:0012043)1.73462507
183Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73374997
184Dicarboxylic aciduria (HP:0003215)1.73374997
185Abnormal lung lobation (HP:0002101)1.72369489
186Triphalangeal thumb (HP:0001199)1.70406058
187Generalized aminoaciduria (HP:0002909)1.70039987
188Pallor (HP:0000980)1.69441584
189Blindness (HP:0000618)1.66347592
190Abnormality of the duodenum (HP:0002246)1.66323296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.60957322
2BUB14.34276430
3EPHA44.01568265
4MAP3K93.89290615
5MAP3K43.70488874
6NTRK33.44940060
7ZAK3.01783185
8MAP2K72.97378739
9VRK12.96809246
10MAP3K122.83588971
11STK162.53430079
12SRPK12.46790478
13ARAF2.40286119
14CDC72.36612713
15TAF12.32445360
16TNIK2.24561998
17NUAK12.23794049
18BCKDK2.21706557
19PNCK2.15562560
20MAP2K42.12442946
21CASK2.09809814
22RIPK42.04239794
23NTRK22.03335217
24MINK12.00299392
25MARK11.99309086
26DAPK21.98236060
27LATS21.94609558
28KSR21.94092671
29WEE11.91744408
30PLK31.90657208
31TLK11.90546209
32MUSK1.88064663
33TRIM281.83695140
34TTK1.78863135
35TSSK61.76635321
36MST41.75858130
37PBK1.75124731
38NME21.74627470
39PAK61.73119834
40MAP4K21.70791417
41MAPK131.68625324
42NEK11.68076200
43EIF2AK11.68000386
44TESK21.61682028
45NTRK11.56599952
46CDK191.56099259
47MAP3K61.55659344
48PLK41.44261894
49CCNB11.43428875
50WNK31.41681612
51MAP3K131.40775262
52PRKD31.39457715
53CSNK1G31.35339301
54BMPR1B1.33247036
55GRK51.32485189
56KDR1.32208683
57NME11.32125263
58PLK11.31495472
59PDK21.30148770
60CHEK21.27682758
61STK381.25696639
62CAMK2A1.23946357
63CDK51.22302855
64DYRK21.21840004
65PLK21.20275796
66EIF2AK31.20106379
67RAF11.18458204
68FES1.16743291
69CSNK1G11.16060282
70LIMK11.14652627
71PHKG11.13014682
72PHKG21.13014682
73AURKB1.12349959
74BRSK21.12232206
75MKNK11.12158738
76DAPK11.10658442
77ATR1.10140346
78PINK11.06480301
79OXSR11.03381029
80BMPR21.03040639
81MKNK21.01441526
82AURKA1.01078941
83TYRO31.00743672
84LMTK20.98748512
85KSR10.98611462
86BRAF0.98324550
87MAPKAPK50.97624626
88UHMK10.94618785
89FGR0.91110531
90PAK30.90832925
91STK110.89075224
92CDK80.88215746
93GRK70.87465427
94DMPK0.86772946
95MYLK0.84395878
96BRSK10.84386351
97PRKCG0.83910660
98CSNK1A1L0.80986184
99PIM20.80766115
100RPS6KA50.79102591
101EIF2AK20.78089011
102PTK2B0.77463669
103SIK20.75847922
104CDC42BPA0.75034809
105SGK2230.74884712
106SGK4940.74884712
107STK40.72061920
108GRK10.69809338
109CAMK10.69231081
110CDK150.67409275
111STK390.67328537
112CDK180.66534611
113ROCK20.65856479
114CAMK2D0.65798734
115CAMKK10.64419449
116FRK0.63886732
117TNK20.62375092
118CSNK2A10.62345695
119PASK0.62300284
120DAPK30.62140633
121CAMK2B0.60941942
122CSNK1G20.60391357
123CSNK2A20.60300198
124SGK10.60298319
125CDK140.60177840
126NEK20.59649036
127CDK11A0.58595854
128PRKCE0.57595037
129SGK20.56777955
130PKN10.56480308
131ERBB40.56181583
132CDK70.55701191
133CAMK1G0.53767339
134CHEK10.53602491
135DYRK1A0.53465305
136ATM0.52025414
137INSRR0.52021426
138STK38L0.51833470
139TAOK10.51508646
140ILK0.49874943
141PRPF4B0.47654445
142RET0.46918684
143PRKD20.46882266
144MOS0.46875854
145TESK10.46762124
146MARK20.45033514
147RPS6KA30.44093278
148PAK10.43966871
149ADRBK20.43371265
150CAMK2G0.43306535
151WNK10.42935080
152TAOK30.42796040
153PRKACA0.42510777
154ROCK10.42031944
155PRKCI0.41810577
156CSNK1E0.41702252
157PRKCH0.41139904
158MAP3K10.40362726
159PRKG10.40004909
160CDK30.39326908
161MAPK100.38951635
162DYRK30.38798294
163ADRBK10.36492559
164WNK40.36336717
165CSNK1A10.34532236
166ABL20.33052318
167BCR0.32869656
168RPS6KA40.32811334
169SMG10.30073145
170CDK10.26454706

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08079911
2Nicotine addiction_Homo sapiens_hsa050334.02548160
3Ribosome_Homo sapiens_hsa030103.49650514
4Oxidative phosphorylation_Homo sapiens_hsa001903.39238654
5DNA replication_Homo sapiens_hsa030303.23248567
6Synaptic vesicle cycle_Homo sapiens_hsa047213.08280895
7Mismatch repair_Homo sapiens_hsa034302.85013964
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84014728
9Cardiac muscle contraction_Homo sapiens_hsa042602.83635525
10Parkinsons disease_Homo sapiens_hsa050122.76662511
11Homologous recombination_Homo sapiens_hsa034402.67590880
12Olfactory transduction_Homo sapiens_hsa047402.64224060
13GABAergic synapse_Homo sapiens_hsa047272.61335226
14Protein export_Homo sapiens_hsa030602.54712340
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50529439
16Morphine addiction_Homo sapiens_hsa050322.42094019
17Glutamatergic synapse_Homo sapiens_hsa047242.39427067
18Circadian entrainment_Homo sapiens_hsa047132.37747926
19Alzheimers disease_Homo sapiens_hsa050102.35981709
20Long-term potentiation_Homo sapiens_hsa047202.35605171
21Base excision repair_Homo sapiens_hsa034102.29715938
22Amphetamine addiction_Homo sapiens_hsa050312.23037645
23Huntingtons disease_Homo sapiens_hsa050162.13878366
24Collecting duct acid secretion_Homo sapiens_hsa049662.03137805
25One carbon pool by folate_Homo sapiens_hsa006702.00814809
26Fanconi anemia pathway_Homo sapiens_hsa034601.99546632
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99373376
28Dopaminergic synapse_Homo sapiens_hsa047281.99169563
29Taste transduction_Homo sapiens_hsa047421.98066193
30Nucleotide excision repair_Homo sapiens_hsa034201.92138640
31Pyrimidine metabolism_Homo sapiens_hsa002401.90233530
32Salivary secretion_Homo sapiens_hsa049701.85992608
33Serotonergic synapse_Homo sapiens_hsa047261.82601193
34Spliceosome_Homo sapiens_hsa030401.81791009
35Insulin secretion_Homo sapiens_hsa049111.80564879
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72945014
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72147049
38Cholinergic synapse_Homo sapiens_hsa047251.71572148
39Renin secretion_Homo sapiens_hsa049241.66857511
40Gastric acid secretion_Homo sapiens_hsa049711.63205602
41Non-homologous end-joining_Homo sapiens_hsa034501.62828004
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62446033
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62347291
44Long-term depression_Homo sapiens_hsa047301.58006262
45Oxytocin signaling pathway_Homo sapiens_hsa049211.58003552
46GnRH signaling pathway_Homo sapiens_hsa049121.57309163
47Calcium signaling pathway_Homo sapiens_hsa040201.56616025
48RNA transport_Homo sapiens_hsa030131.53045110
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50669781
50Cocaine addiction_Homo sapiens_hsa050301.47373658
51Fatty acid elongation_Homo sapiens_hsa000621.46574277
52Sulfur relay system_Homo sapiens_hsa041221.44647080
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44639829
54Propanoate metabolism_Homo sapiens_hsa006401.43958217
55Folate biosynthesis_Homo sapiens_hsa007901.40438270
56Dilated cardiomyopathy_Homo sapiens_hsa054141.40181804
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39158053
58RNA degradation_Homo sapiens_hsa030181.39067942
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38374232
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.37224532
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36666021
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36163062
63Purine metabolism_Homo sapiens_hsa002301.32139105
64Pyruvate metabolism_Homo sapiens_hsa006201.31211501
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26028555
66Phototransduction_Homo sapiens_hsa047441.24487460
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18272640
68Steroid biosynthesis_Homo sapiens_hsa001001.17280138
69cAMP signaling pathway_Homo sapiens_hsa040241.14797915
70Gap junction_Homo sapiens_hsa045401.14654003
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13923706
72Oocyte meiosis_Homo sapiens_hsa041141.13457814
73Cell cycle_Homo sapiens_hsa041101.11680021
74Biosynthesis of amino acids_Homo sapiens_hsa012301.04015523
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01806467
76Vibrio cholerae infection_Homo sapiens_hsa051101.01745221
77Estrogen signaling pathway_Homo sapiens_hsa049151.01500785
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00962508
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.99485532
80Glutathione metabolism_Homo sapiens_hsa004800.98947789
81Peroxisome_Homo sapiens_hsa041460.95428670
82Melanogenesis_Homo sapiens_hsa049160.95293546
83Carbon metabolism_Homo sapiens_hsa012000.92532273
84Sulfur metabolism_Homo sapiens_hsa009200.92279415
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91345551
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90822268
87Metabolic pathways_Homo sapiens_hsa011000.88083265
88Selenocompound metabolism_Homo sapiens_hsa004500.85009602
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79025571
90Dorso-ventral axis formation_Homo sapiens_hsa043200.78398543
91Type II diabetes mellitus_Homo sapiens_hsa049300.75943491
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75475611
93N-Glycan biosynthesis_Homo sapiens_hsa005100.75054320
94Axon guidance_Homo sapiens_hsa043600.74206175
95Glioma_Homo sapiens_hsa052140.74035106
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73415108
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73036525
98ErbB signaling pathway_Homo sapiens_hsa040120.71498346
99Circadian rhythm_Homo sapiens_hsa047100.69967307
100Ovarian steroidogenesis_Homo sapiens_hsa049130.67975867
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67938958
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.64464522
103Vitamin B6 metabolism_Homo sapiens_hsa007500.61213756
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60669498
105Choline metabolism in cancer_Homo sapiens_hsa052310.60617460
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.59290044
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57859230
108MAPK signaling pathway_Homo sapiens_hsa040100.57501458
109Fatty acid metabolism_Homo sapiens_hsa012120.57353118
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56621568
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56451056
112Glucagon signaling pathway_Homo sapiens_hsa049220.56129369
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55079041
114Arginine and proline metabolism_Homo sapiens_hsa003300.53762423
115Ras signaling pathway_Homo sapiens_hsa040140.52563787
116Pancreatic secretion_Homo sapiens_hsa049720.52259317
117mRNA surveillance pathway_Homo sapiens_hsa030150.51390303
118Tryptophan metabolism_Homo sapiens_hsa003800.51007003
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.49413794
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47826337
121Ether lipid metabolism_Homo sapiens_hsa005650.47560759
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47301543
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.46311807
124Thyroid hormone synthesis_Homo sapiens_hsa049180.46229949
125p53 signaling pathway_Homo sapiens_hsa041150.44986462
126Chemical carcinogenesis_Homo sapiens_hsa052040.44306980
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44273462
128Regulation of autophagy_Homo sapiens_hsa041400.44068227
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42664579
130Inositol phosphate metabolism_Homo sapiens_hsa005620.42192050
131Pentose phosphate pathway_Homo sapiens_hsa000300.42029822
132Rheumatoid arthritis_Homo sapiens_hsa053230.41862680
133Systemic lupus erythematosus_Homo sapiens_hsa053220.41579320
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41063891
135Renal cell carcinoma_Homo sapiens_hsa052110.40882445
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40617250
137Fatty acid degradation_Homo sapiens_hsa000710.40496978
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39328108
139Alcoholism_Homo sapiens_hsa050340.38815064
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38027252
141RNA polymerase_Homo sapiens_hsa030200.37730494
142VEGF signaling pathway_Homo sapiens_hsa043700.36642931
143Tyrosine metabolism_Homo sapiens_hsa003500.36175830
144Wnt signaling pathway_Homo sapiens_hsa043100.35763022
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35408216
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34622411
147beta-Alanine metabolism_Homo sapiens_hsa004100.33548684
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.33097748
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31001542
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30618335
151Caffeine metabolism_Homo sapiens_hsa002320.30319246
152Rap1 signaling pathway_Homo sapiens_hsa040150.29483192
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28308083
154Nitrogen metabolism_Homo sapiens_hsa009100.28090007
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27621550
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26662097
157Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25709529
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.25135211
159Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24768216
160Prion diseases_Homo sapiens_hsa050200.24429380
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24323955
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24125656
163Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23802616
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.23618206
165Retinol metabolism_Homo sapiens_hsa008300.22975529
166Fructose and mannose metabolism_Homo sapiens_hsa000510.22845162
167Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22541158
168Insulin signaling pathway_Homo sapiens_hsa049100.21939542
169Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21761676
170Epstein-Barr virus infection_Homo sapiens_hsa051690.19491007
171Type I diabetes mellitus_Homo sapiens_hsa049400.17876997
172Primary immunodeficiency_Homo sapiens_hsa053400.17615528
173Tight junction_Homo sapiens_hsa045300.16206369
174Linoleic acid metabolism_Homo sapiens_hsa005910.16141225
175Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14970140
176Basal cell carcinoma_Homo sapiens_hsa052170.14462337
177Basal transcription factors_Homo sapiens_hsa030220.12776650
178Butanoate metabolism_Homo sapiens_hsa006500.12263323
179African trypanosomiasis_Homo sapiens_hsa051430.11359407

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