EMBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)5.98223636
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.89372115
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78158035
4regulation of regulatory T cell differentiation (GO:0045589)5.41218293
5positive regulation of gamma-delta T cell activation (GO:0046645)5.35431227
6response to interleukin-15 (GO:0070672)5.31022377
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.28569144
8negative regulation of cell killing (GO:0031342)5.28569144
9DNA deamination (GO:0045006)5.18048572
10negative T cell selection (GO:0043383)5.17251337
11regulation of B cell receptor signaling pathway (GO:0050855)5.16907670
12cytidine metabolic process (GO:0046087)5.15592408
13cytidine catabolic process (GO:0006216)5.15592408
14cytidine deamination (GO:0009972)5.15592408
15pyrimidine ribonucleoside catabolic process (GO:0046133)4.95214833
16regulation of gamma-delta T cell differentiation (GO:0045586)4.93584249
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.69126010
18negative thymic T cell selection (GO:0045060)4.60953201
19T cell migration (GO:0072678)4.60741780
20positive T cell selection (GO:0043368)4.56326457
21positive thymic T cell selection (GO:0045059)4.54184153
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.49208398
23positive regulation of T cell mediated cytotoxicity (GO:0001916)4.41505406
24regulation of gamma-delta T cell activation (GO:0046643)4.40144289
25regulation of leukocyte mediated cytotoxicity (GO:0001910)4.29992202
26positive regulation of natural killer cell mediated immunity (GO:0002717)4.28459863
27negative regulation of T cell apoptotic process (GO:0070233)4.28200776
28regulation of T cell mediated cytotoxicity (GO:0001914)4.25581424
29regulation of natural killer cell mediated immunity (GO:0002715)4.17958590
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.17958590
31positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.15785547
32regulation of T cell tolerance induction (GO:0002664)4.07520822
33thymic T cell selection (GO:0045061)3.99156274
34positive regulation of cell killing (GO:0031343)3.98396365
35positive regulation of tolerance induction (GO:0002645)3.96455926
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.88622224
37tolerance induction (GO:0002507)3.87864709
38regulation of cell killing (GO:0031341)3.86404387
39regulation of activation of Janus kinase activity (GO:0010533)3.83590282
40T cell selection (GO:0045058)3.77411247
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.77225799
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.74172513
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.71120004
44interferon-gamma production (GO:0032609)3.69224557
45mast cell activation (GO:0045576)3.68914649
46regulation of alpha-beta T cell proliferation (GO:0046640)3.65730930
47T cell receptor signaling pathway (GO:0050852)3.60882391
48positive regulation of calcium-mediated signaling (GO:0050850)3.58400494
49negative regulation by host of viral transcription (GO:0043922)3.56565066
50positive regulation of defense response to virus by host (GO:0002230)3.55949342
51positive regulation of interleukin-17 production (GO:0032740)3.53650255
52regulation of isotype switching to IgG isotypes (GO:0048302)3.50842110
53Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48370491
54CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.47870333
55T-helper cell differentiation (GO:0042093)3.47870333
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47592752
57regulation of T cell receptor signaling pathway (GO:0050856)3.46600517
58antigen processing and presentation of endogenous antigen (GO:0019883)3.45534950
59natural killer cell activation (GO:0030101)3.38415881
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37831361
61T cell differentiation (GO:0030217)3.36982969
62positive regulation of T cell mediated immunity (GO:0002711)3.35781750
63regulation of tolerance induction (GO:0002643)3.35315884
64alpha-beta T cell differentiation (GO:0046632)3.34872929
65positive regulation of interleukin-4 production (GO:0032753)3.34210880
66negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.25481423
67regulation of B cell differentiation (GO:0045577)3.22811661
68negative regulation of lymphocyte apoptotic process (GO:0070229)3.22770465
69antigen receptor-mediated signaling pathway (GO:0050851)3.19912629
70regulation of chronic inflammatory response (GO:0002676)3.19853809
71alpha-beta T cell activation (GO:0046631)3.16848703
72alpha-beta T cell differentiation involved in immune response (GO:0002293)3.16012170
73alpha-beta T cell activation involved in immune response (GO:0002287)3.16012170
74T cell differentiation involved in immune response (GO:0002292)3.16012170
75actin nucleation (GO:0045010)3.14434453
76cellular defense response (GO:0006968)3.13523615
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.12331609
78dendritic cell chemotaxis (GO:0002407)3.09628885
79T cell costimulation (GO:0031295)3.09285150
80negative regulation of T cell mediated immunity (GO:0002710)3.08404118
81positive regulation of lymphocyte mediated immunity (GO:0002708)3.06490207
82lymphocyte costimulation (GO:0031294)3.04938712
83regulation of T cell mediated immunity (GO:0002709)3.04068299
84positive regulation of natural killer cell differentiation (GO:0032825)3.03261510
85positive regulation of granulocyte differentiation (GO:0030854)3.02418627
86cytolysis (GO:0019835)3.01730002
87T cell activation (GO:0042110)3.00061037
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99653343
89regulation of interleukin-12 biosynthetic process (GO:0045075)2.99407694
90positive regulation of T cell chemotaxis (GO:0010820)2.98716125
91regulation of T cell chemotaxis (GO:0010819)2.98716125
92lymphocyte migration (GO:0072676)2.97915178
93regulation of T cell apoptotic process (GO:0070232)2.97879466
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.97851579
95regulation of defense response to virus by host (GO:0050691)2.96068683
96positive regulation of B cell differentiation (GO:0045579)2.92294106
97antigen processing and presentation via MHC class Ib (GO:0002475)2.90708596
98mast cell degranulation (GO:0043303)2.89611740
99mast cell activation involved in immune response (GO:0002279)2.89611740
100positive regulation of interleukin-8 secretion (GO:2000484)2.89212716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.27621194
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.14714858
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.61926538
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.59055654
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68008464
6RUNX_20019798_ChIP-Seq_JUKART_Human3.57205686
7MYB_26560356_Chip-Seq_TH2_Human3.41753892
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32673548
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.22006722
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78241844
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.78015257
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76376626
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74407191
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62850435
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.50490373
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47488909
17GATA3_27048872_Chip-Seq_THYMUS_Human2.41586089
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35097195
19MYB_26560356_Chip-Seq_TH1_Human2.28146765
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27616856
21GATA3_26560356_Chip-Seq_TH2_Human2.17972449
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15064775
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07360770
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04408142
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03621481
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.02564453
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99027401
28VDR_23849224_ChIP-Seq_CD4+_Human1.88051299
29UTX_26944678_Chip-Seq_JUKART_Human1.77252039
30VDR_22108803_ChIP-Seq_LS180_Human1.68927156
31MAF_26560356_Chip-Seq_TH1_Human1.68501558
32SPI1_23547873_ChIP-Seq_NB4_Human1.64177476
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.58471768
34FOXP3_21729870_ChIP-Seq_TREG_Human1.56032308
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.55240601
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54704690
37IGF1R_20145208_ChIP-Seq_DFB_Human1.51774307
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50053262
39RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48341847
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45099340
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42781089
42ZNF274_21170338_ChIP-Seq_K562_Hela1.36757536
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36618112
44TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36240066
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35756962
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.34422873
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33110301
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32229177
49GATA3_26560356_Chip-Seq_TH1_Human1.31740589
50MAF_26560356_Chip-Seq_TH2_Human1.26677690
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.23967945
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21542679
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17037949
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15947823
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15782398
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14068438
57TAF15_26573619_Chip-Seq_HEK293_Human1.13621421
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12819520
59ER_23166858_ChIP-Seq_MCF-7_Human1.11452270
60RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10430206
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.07627492
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.05403425
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02388844
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01381599
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00633656
66CIITA_25753668_ChIP-Seq_RAJI_Human0.99915368
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99508421
68CRX_20693478_ChIP-Seq_RETINA_Mouse0.98989561
69MYC_18940864_ChIP-ChIP_HL60_Human0.94554417
70SCL_19346495_ChIP-Seq_HPC-7_Human0.93843425
71RUNX1_22412390_ChIP-Seq_EML_Mouse0.93417274
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92735992
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.92494603
74* TP53_22573176_ChIP-Seq_HFKS_Human0.91677326
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91023271
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90985294
77MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90975625
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90347398
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89985005
80AR_20517297_ChIP-Seq_VCAP_Human0.89204022
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88009787
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87871662
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87522570
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.87522570
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87405626
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87065948
87BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86437154
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85495374
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84968532
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84470028
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.83572246
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83368374
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83321409
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82829588
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82513237
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81341820
97NCOR_22424771_ChIP-Seq_293T_Human0.81014668
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80997744
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80892103
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.80800219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.69185408
2MP0001835_abnormal_antigen_presentation3.77625629
3MP0003763_abnormal_thymus_physiology3.73920243
4MP0009785_altered_susceptibility_to3.46501658
5MP0005000_abnormal_immune_tolerance3.15265568
6MP0001800_abnormal_humoral_immune2.99390690
7MP0003724_increased_susceptibility_to2.80983054
8MP0002723_abnormal_immune_serum2.75182509
9MP0009333_abnormal_splenocyte_physiolog2.71257323
10MP0005075_abnormal_melanosome_morpholog2.71094623
11MP0002420_abnormal_adaptive_immunity2.67720810
12MP0001819_abnormal_immune_cell2.66641185
13MP0003436_decreased_susceptibility_to2.56203797
14MP0005025_abnormal_response_to2.54358079
15MP0000685_abnormal_immune_system2.46521747
16MP0001790_abnormal_immune_system2.40377460
17MP0005387_immune_system_phenotype2.40377460
18MP0002452_abnormal_antigen_presenting2.38381034
19MP0006082_CNS_inflammation2.35446990
20MP0002166_altered_tumor_susceptibility2.28000515
21MP0002148_abnormal_hypersensitivity_rea2.23792499
22MP0003866_abnormal_defecation2.22622656
23MP0010155_abnormal_intestine_physiology2.17732147
24MP0002398_abnormal_bone_marrow2.12302387
25MP0000703_abnormal_thymus_morphology2.10115354
26MP0002405_respiratory_system_inflammati2.08491843
27MP0002419_abnormal_innate_immunity2.03481740
28MP0000716_abnormal_immune_system2.02511437
29MP0002722_abnormal_immune_system1.90519174
30MP0000689_abnormal_spleen_morphology1.90173200
31MP0000569_abnormal_digit_pigmentation1.82738482
32MP0002006_tumorigenesis1.78903709
33MP0004381_abnormal_hair_follicle1.74496382
34MP0003195_calcinosis1.72322287
35MP0001845_abnormal_inflammatory_respons1.68950539
36MP0001873_stomach_inflammation1.65575099
37MP0002876_abnormal_thyroid_physiology1.61384106
38MP0002429_abnormal_blood_cell1.57491787
39MP0004947_skin_inflammation1.57221221
40MP0002933_joint_inflammation1.55928118
41MP0000465_gastrointestinal_hemorrhage1.53423134
42MP0001661_extended_life_span1.52264372
43MP0008877_abnormal_DNA_methylation1.36483115
44MP0002009_preneoplasia1.36261728
45MP0001533_abnormal_skeleton_physiology1.34266459
46MP0008469_abnormal_protein_level1.29035778
47MP0009764_decreased_sensitivity_to1.28387965
48MP0005464_abnormal_platelet_physiology1.27959742
49MP0001853_heart_inflammation1.22292595
50MP0005310_abnormal_salivary_gland1.20009629
51MP0008875_abnormal_xenobiotic_pharmacok1.15473360
52MP0003252_abnormal_bile_duct1.05504166
53MP0006072_abnormal_retinal_apoptosis1.04798965
54MP0002138_abnormal_hepatobiliary_system1.04582317
55MP0001919_abnormal_reproductive_system1.02811761
56MP0003786_premature_aging0.98875745
57MP0003448_altered_tumor_morphology0.96495155
58MP0002277_abnormal_respiratory_mucosa0.95905459
59MP0009763_increased_sensitivity_to0.93914512
60MP0004043_abnormal_pH_regulation0.88227117
61MP0002019_abnormal_tumor_incidence0.87698282
62MP0002693_abnormal_pancreas_physiology0.86458263
63MP0002396_abnormal_hematopoietic_system0.84262361
64MP0005360_urolithiasis0.83912027
65MP0008872_abnormal_physiological_respon0.82464433
66MP0002638_abnormal_pupillary_reflex0.81755249
67MP0005377_hearing/vestibular/ear_phenot0.81112835
68MP0003878_abnormal_ear_physiology0.81112835
69MP0005645_abnormal_hypothalamus_physiol0.81107694
70MP0000604_amyloidosis0.80002230
71MP0005451_abnormal_body_composition0.77271243
72MP0000372_irregular_coat_pigmentation0.75053215
73MP0005389_reproductive_system_phenotype0.74672525
74MP0003656_abnormal_erythrocyte_physiolo0.74549068
75MP0005085_abnormal_gallbladder_physiolo0.70371958
76MP0001765_abnormal_ion_homeostasis0.70210908
77MP0005551_abnormal_eye_electrophysiolog0.68541599
78MP0003300_gastrointestinal_ulcer0.68235781
79MP0005365_abnormal_bile_salt0.67210267
80MP0002095_abnormal_skin_pigmentation0.66579147
81MP0004147_increased_porphyrin_level0.65669292
82MP0003045_fibrosis0.62706411
83MP0004130_abnormal_muscle_cell0.62256792
84MP0005174_abnormal_tail_pigmentation0.61881942
85MP0000858_altered_metastatic_potential0.60965512
86MP0002102_abnormal_ear_morphology0.60938178
87MP0000490_abnormal_crypts_of0.60619425
88MP0003646_muscle_fatigue0.60413563
89MP0003075_altered_response_to0.57819636
90MP0005410_abnormal_fertilization0.57483171
91MP0002163_abnormal_gland_morphology0.55603335
92MP0003638_abnormal_response/metabolism_0.55131666
93MP0004742_abnormal_vestibular_system0.54332156
94MP0002998_abnormal_bone_remodeling0.54074937
95MP0002254_reproductive_system_inflammat0.53548705
96MP0001501_abnormal_sleep_pattern0.53444306
97MP0005166_decreased_susceptibility_to0.52856790
98MP0001986_abnormal_taste_sensitivity0.52775982
99MP0009765_abnormal_xenobiotic_induced0.52629692
100MP0002136_abnormal_kidney_physiology0.52400157

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.66211719
2Abnormality of T cell number (HP:0011839)6.02629041
3IgG deficiency (HP:0004315)5.82112622
4Severe combined immunodeficiency (HP:0004430)4.89221952
5Abnormality of T cells (HP:0002843)4.77919980
6Elevated erythrocyte sedimentation rate (HP:0003565)4.31807648
7B lymphocytopenia (HP:0010976)4.29176411
8Abnormality of B cell number (HP:0010975)4.10875459
9Stomatitis (HP:0010280)4.01199677
10Combined immunodeficiency (HP:0005387)3.97272866
11Optic neuritis (HP:0100653)3.86441848
12Retrobulbar optic neuritis (HP:0100654)3.86441848
13Myositis (HP:0100614)3.78206402
14Thyroiditis (HP:0100646)3.71334750
15Hypoproteinemia (HP:0003075)3.48461248
16Autoimmune hemolytic anemia (HP:0001890)3.45826727
17Encephalitis (HP:0002383)3.41321835
18Orchitis (HP:0100796)3.39626412
19Increased IgM level (HP:0003496)3.33403712
20Chronic diarrhea (HP:0002028)3.30057562
21Recurrent bronchitis (HP:0002837)3.25954020
22Abnormality of eosinophils (HP:0001879)3.23332305
23Abnormality of T cell physiology (HP:0011840)3.21315173
24Gangrene (HP:0100758)3.17931919
25Recurrent cutaneous fungal infections (HP:0011370)3.09502502
26Chronic mucocutaneous candidiasis (HP:0002728)3.09502502
27IgM deficiency (HP:0002850)3.04172245
28Lymphopenia (HP:0001888)3.02392262
29Recurrent fungal infections (HP:0002841)2.98797982
30Keratoconjunctivitis (HP:0001096)2.90782308
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.90040798
32Joint swelling (HP:0001386)2.88416125
33Pustule (HP:0200039)2.87883672
34Keratoconjunctivitis sicca (HP:0001097)2.80633881
35Abnormality of cells of the lymphoid lineage (HP:0012140)2.73681671
36Meningitis (HP:0001287)2.71793279
37Abnormality of the prostate (HP:0008775)2.71146894
38Aplastic anemia (HP:0001915)2.69368494
39Leukocytosis (HP:0001974)2.62076291
40Congenital stationary night blindness (HP:0007642)2.60372347
41Vasculitis (HP:0002633)2.59993893
42Gastrointestinal infarctions (HP:0005244)2.56612309
43Renal cortical cysts (HP:0000803)2.55826180
44Panhypogammaglobulinemia (HP:0003139)2.55672256
45Pulmonary infiltrates (HP:0002113)2.54932614
46Reduced antithrombin III activity (HP:0001976)2.52363970
47Hypoplasia of the thymus (HP:0000778)2.47999696
48Anorexia (HP:0002039)2.46476593
49Conical tooth (HP:0000698)2.45469580
50Hemoptysis (HP:0002105)2.38740236
51Amyotrophic lateral sclerosis (HP:0007354)2.36041813
52Recurrent viral infections (HP:0004429)2.35921894
53Parakeratosis (HP:0001036)2.35710656
54Recurrent skin infections (HP:0001581)2.33287486
55Hypoalbuminemia (HP:0003073)2.30500914
56Abnormal albumin level (HP:0012116)2.30500914
57Abnormality of macrophages (HP:0004311)2.27437965
58Eosinophilia (HP:0001880)2.27158389
59Bronchitis (HP:0012387)2.25017198
60IgA deficiency (HP:0002720)2.21007679
61Abolished electroretinogram (ERG) (HP:0000550)2.18315911
62Chronic obstructive pulmonary disease (HP:0006510)2.13952620
63Obstructive lung disease (HP:0006536)2.13952620
64Lymphoma (HP:0002665)2.13275177
65Abnormality of the pons (HP:0007361)2.11992264
66Pulmonary embolism (HP:0002204)2.10297402
67Recurrent abscess formation (HP:0002722)2.09460318
68Abnormal protein glycosylation (HP:0012346)2.08758943
69Abnormal glycosylation (HP:0012345)2.08758943
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08758943
71Abnormal protein N-linked glycosylation (HP:0012347)2.08758943
72Recurrent bacterial skin infections (HP:0005406)2.08328339
73Acute hepatic failure (HP:0006554)2.06911543
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06397125
75Abnormality of the pleura (HP:0002103)2.06280385
76Arterial thrombosis (HP:0004420)2.03278495
77Abnormal rod and cone electroretinograms (HP:0008323)2.02347654
78Acanthocytosis (HP:0001927)2.02030126
79Granulocytopenia (HP:0001913)1.99782717
80Keratitis (HP:0000491)1.98714369
81Type I transferrin isoform profile (HP:0003642)1.97816089
82Pancytopenia (HP:0001876)1.95559473
83Chest pain (HP:0100749)1.92721755
84Mediastinal lymphadenopathy (HP:0100721)1.91405197
85Stomach cancer (HP:0012126)1.89828454
86Prostate neoplasm (HP:0100787)1.88141284
87Polyneuropathy (HP:0001271)1.85462977
88Eczematoid dermatitis (HP:0000976)1.84612909
89Long nose (HP:0003189)1.82660189
90Abnormality of the renal cortex (HP:0011035)1.82542539
91Carpal bone hypoplasia (HP:0001498)1.77863664
92Alveolar cell carcinoma (HP:0006519)1.73956420
93Pancreatitis (HP:0001733)1.73265703
94Hypoplasia of the pons (HP:0012110)1.72090003
95Increased intramyocellular lipid droplets (HP:0012240)1.71816257
96Erythroderma (HP:0001019)1.71749502
97Premature loss of primary teeth (HP:0006323)1.71730718
98Pancreatic cysts (HP:0001737)1.71282968
99Abnormality of the alveolar ridges (HP:0006477)1.67904277
100Autoimmune thrombocytopenia (HP:0001973)1.67637672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.11674901
2MAP4K13.33701218
3GRK63.17800002
4ITK3.16959179
5KDR3.15370289
6TAOK32.95984518
7TEC2.74165769
8TESK22.56765698
9MAP4K22.56199800
10NME12.39871798
11ZAK2.22683371
12TLK12.22014925
13BCKDK2.18711198
14SYK2.08979134
15MAP3K142.03672950
16IKBKE2.01700313
17BTK2.01654394
18FES1.83826358
19LCK1.79875723
20FRK1.72904107
21IKBKB1.68580792
22ADRBK21.63179571
23TBK11.61547954
24ZAP701.50554353
25CSK1.49374511
26NUAK11.49307772
27INSRR1.49136731
28MAP2K21.49081605
29LYN1.41650095
30PRKCQ1.38357233
31GRK71.25558737
32PASK1.23554136
33JAK31.20234395
34IRAK41.17645294
35TNK21.12089287
36WNK41.00472856
37PIM10.94952073
38HCK0.94586285
39JAK10.90936994
40CSF1R0.89854604
41MAP2K60.87846568
42GRK10.87631836
43SCYL20.86786857
44RPS6KA40.83997617
45RIPK40.83826239
46PIK3CG0.83387322
47TYK20.82660628
48MST40.82132380
49CAMKK20.76187192
50KIT0.72636828
51CDK40.68766270
52MATK0.68734390
53NLK0.66886303
54LIMK10.64719315
55ACVR1B0.64291386
56IGF1R0.61890989
57PINK10.59131690
58BUB10.57654362
59BMPR20.53656435
60BLK0.52849257
61VRK10.51072487
62MAP3K120.50880114
63PIK3CA0.50760298
64FYN0.50141346
65ABL10.47910718
66EIF2AK20.47737217
67EIF2AK30.44089640
68EGFR0.42083936
69JAK20.40896143
70CAMKK10.40032437
71CDK190.39485389
72CLK10.38967791
73INSR0.38231719
74TESK10.36562885
75MAPK110.34674121
76CHUK0.34621810
77RPS6KA50.33168230
78CDK30.31190742
79MAPK70.30357323
80FGR0.30185649
81PDK10.28886966
82MARK30.28817947
83OXSR10.27012404
84MAP3K130.26608531
85TGFBR20.26563302
86WNK10.26241791
87NEK60.25831950
88PRKCB0.24006122
89TRPM70.23237893
90MAP3K110.22958487
91MAPKAPK20.22392406
92PRKCH0.21178920
93MAPK30.20871866
94BCR0.20637495
95BRSK20.20374884
96PRKCA0.19631771
97IRAK10.19596014
98ATR0.18855408
99ERBB30.18430756
100ADRBK10.16346260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.90170477
2Graft-versus-host disease_Homo sapiens_hsa053323.47583099
3T cell receptor signaling pathway_Homo sapiens_hsa046603.22415408
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.16503370
5Antigen processing and presentation_Homo sapiens_hsa046123.09824142
6Autoimmune thyroid disease_Homo sapiens_hsa053203.02013253
7Allograft rejection_Homo sapiens_hsa053303.00522085
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70438053
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.68148465
10Type I diabetes mellitus_Homo sapiens_hsa049402.66641020
11Hematopoietic cell lineage_Homo sapiens_hsa046402.59834505
12Proteasome_Homo sapiens_hsa030502.24906769
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.21887886
14Measles_Homo sapiens_hsa051622.05577954
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.00343411
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79958075
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58698442
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58398172
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53670311
20Rheumatoid arthritis_Homo sapiens_hsa053231.41980991
21RNA polymerase_Homo sapiens_hsa030201.39567389
22Caffeine metabolism_Homo sapiens_hsa002321.37878763
23Asthma_Homo sapiens_hsa053101.33351786
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.28525752
25Linoleic acid metabolism_Homo sapiens_hsa005911.19246552
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13604855
27One carbon pool by folate_Homo sapiens_hsa006701.12448673
28Leishmaniasis_Homo sapiens_hsa051401.12026817
29Herpes simplex infection_Homo sapiens_hsa051681.10112949
30Malaria_Homo sapiens_hsa051441.09038335
31Phototransduction_Homo sapiens_hsa047441.07294777
32Viral myocarditis_Homo sapiens_hsa054161.05772486
33Osteoclast differentiation_Homo sapiens_hsa043801.05174119
34Legionellosis_Homo sapiens_hsa051341.04058686
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02311122
36Staphylococcus aureus infection_Homo sapiens_hsa051500.99210903
37Nitrogen metabolism_Homo sapiens_hsa009100.98080545
38TNF signaling pathway_Homo sapiens_hsa046680.96485611
39B cell receptor signaling pathway_Homo sapiens_hsa046620.96348391
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94193433
41Protein export_Homo sapiens_hsa030600.93027447
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91751447
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89544188
44RNA degradation_Homo sapiens_hsa030180.85739779
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83879907
46Homologous recombination_Homo sapiens_hsa034400.81960978
47Regulation of autophagy_Homo sapiens_hsa041400.77173502
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.76639665
49Fanconi anemia pathway_Homo sapiens_hsa034600.76420631
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.72377338
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71518036
52Retinol metabolism_Homo sapiens_hsa008300.70741570
53Oxidative phosphorylation_Homo sapiens_hsa001900.69997378
54Chemokine signaling pathway_Homo sapiens_hsa040620.68157700
55Shigellosis_Homo sapiens_hsa051310.67724583
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.65192319
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64531394
58Peroxisome_Homo sapiens_hsa041460.61982524
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.60514215
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55893372
61Taste transduction_Homo sapiens_hsa047420.53973030
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53764630
63Ribosome_Homo sapiens_hsa030100.53669108
64Apoptosis_Homo sapiens_hsa042100.53647642
65Arachidonic acid metabolism_Homo sapiens_hsa005900.53052759
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52965665
67Pertussis_Homo sapiens_hsa051330.52912810
68Pyrimidine metabolism_Homo sapiens_hsa002400.51359782
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50779218
70Chemical carcinogenesis_Homo sapiens_hsa052040.50696940
71Tuberculosis_Homo sapiens_hsa051520.50561242
72Epstein-Barr virus infection_Homo sapiens_hsa051690.47364135
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47128404
74Ether lipid metabolism_Homo sapiens_hsa005650.46837487
75HTLV-I infection_Homo sapiens_hsa051660.46713531
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46124273
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44948494
78Salmonella infection_Homo sapiens_hsa051320.43884870
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43677453
80Tryptophan metabolism_Homo sapiens_hsa003800.43479556
81Purine metabolism_Homo sapiens_hsa002300.41691671
82Non-homologous end-joining_Homo sapiens_hsa034500.41043170
83Influenza A_Homo sapiens_hsa051640.40060675
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39758228
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39010650
86ABC transporters_Homo sapiens_hsa020100.33890086
87Systemic lupus erythematosus_Homo sapiens_hsa053220.33324313
88African trypanosomiasis_Homo sapiens_hsa051430.32715498
89Olfactory transduction_Homo sapiens_hsa047400.30281817
90Parkinsons disease_Homo sapiens_hsa050120.30007972
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29277803
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29039569
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28268676
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28108480
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27029173
96Toxoplasmosis_Homo sapiens_hsa051450.24705070
97Propanoate metabolism_Homo sapiens_hsa006400.23401375
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22403007
99N-Glycan biosynthesis_Homo sapiens_hsa005100.21398434
100Nucleotide excision repair_Homo sapiens_hsa034200.20766886

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