EMC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.64021583
2muscle filament sliding (GO:0030049)5.64021583
3myofibril assembly (GO:0030239)5.37258902
4synaptic vesicle maturation (GO:0016188)5.33006697
5sarcomere organization (GO:0045214)5.04540001
6cell junction maintenance (GO:0034331)4.93985479
7cardiac myofibril assembly (GO:0055003)4.86723327
8cell-cell junction maintenance (GO:0045217)4.82451700
9actin-mediated cell contraction (GO:0070252)4.69203488
10cardiac chamber formation (GO:0003207)4.54450039
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53560785
12regulation of the force of heart contraction (GO:0002026)4.45967157
13locomotory exploration behavior (GO:0035641)4.43655870
14sarcoplasmic reticulum calcium ion transport (GO:0070296)4.35179487
15outflow tract septum morphogenesis (GO:0003148)4.30832235
16cardiac muscle contraction (GO:0060048)4.19581822
17striated muscle contraction (GO:0006941)3.99434052
18regulation of cardioblast differentiation (GO:0051890)3.99119869
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96185050
20cardiac muscle hypertrophy (GO:0003300)3.78565642
21sodium ion export (GO:0071436)3.77593855
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75661985
23glutamate secretion (GO:0014047)3.73313273
24atrial septum morphogenesis (GO:0060413)3.66124976
25actomyosin structure organization (GO:0031032)3.65135368
26neuronal action potential propagation (GO:0019227)3.63114013
27synaptic vesicle exocytosis (GO:0016079)3.61886784
28striated muscle hypertrophy (GO:0014897)3.58195365
29layer formation in cerebral cortex (GO:0021819)3.57371759
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.57309427
31cerebellar Purkinje cell layer development (GO:0021680)3.54307647
32actin filament-based movement (GO:0030048)3.54019689
33venous blood vessel morphogenesis (GO:0048845)3.53375670
34regulation of synaptic vesicle exocytosis (GO:2000300)3.48934361
35cardiac muscle tissue morphogenesis (GO:0055008)3.48604165
36activation of protein kinase A activity (GO:0034199)3.48453928
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48089761
38endocardial cushion morphogenesis (GO:0003203)3.47326103
39negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.41792316
40neuromuscular process controlling posture (GO:0050884)3.40935728
41regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.37910979
42skeletal muscle contraction (GO:0003009)3.36480277
43epithelial cell-cell adhesion (GO:0090136)3.33377866
44adult heart development (GO:0007512)3.31604731
45regulation of actin filament-based movement (GO:1903115)3.30724884
46glycine transport (GO:0015816)3.29872478
47regulation of relaxation of muscle (GO:1901077)3.29864679
48muscle hypertrophy (GO:0014896)3.29800562
49muscle tissue morphogenesis (GO:0060415)3.29377287
50regulation of early endosome to late endosome transport (GO:2000641)3.27978754
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.27686183
52negative regulation of microtubule polymerization (GO:0031115)3.27091547
53cardiac right ventricle morphogenesis (GO:0003215)3.23901194
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.21812038
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20186517
56membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.20143535
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18480682
58cardiac ventricle formation (GO:0003211)3.17540258
59cardiac conduction (GO:0061337)3.15933341
60regulation of neuronal synaptic plasticity (GO:0048168)3.14968348
61relaxation of cardiac muscle (GO:0055119)3.14620404
62ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.14171330
63regulation of synapse structural plasticity (GO:0051823)3.14083725
64detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.12826085
65detection of temperature stimulus involved in sensory perception (GO:0050961)3.12826085
66cardiac muscle hypertrophy in response to stress (GO:0014898)3.12728464
67muscle hypertrophy in response to stress (GO:0003299)3.12728464
68cardiac muscle adaptation (GO:0014887)3.12728464
69cardiac muscle cell development (GO:0055013)3.12488188
70exploration behavior (GO:0035640)3.11245110
71neurotransmitter secretion (GO:0007269)3.11085513
72regulation of synaptic vesicle transport (GO:1902803)3.10629185
73cellular potassium ion homeostasis (GO:0030007)3.08247677
74regulation of skeletal muscle contraction (GO:0014819)3.08014471
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.06858619
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.05000051
77cellular component maintenance (GO:0043954)3.03954953
78neuromuscular process controlling balance (GO:0050885)3.03411958
79inner ear receptor cell differentiation (GO:0060113)3.03296769
80cell migration in hindbrain (GO:0021535)3.01755717
81cell communication by electrical coupling (GO:0010644)3.00857699
82response to inactivity (GO:0014854)2.97740646
83axon ensheathment in central nervous system (GO:0032291)2.96988556
84central nervous system myelination (GO:0022010)2.96988556
85gamma-aminobutyric acid transport (GO:0015812)2.96577879
86muscle cell fate commitment (GO:0042693)2.95594141
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94872836
88cardiac cell development (GO:0055006)2.93164751
89heart valve formation (GO:0003188)2.91558403
90ventricular cardiac muscle cell action potential (GO:0086005)2.89592452
91dendritic spine morphogenesis (GO:0060997)2.88058798
92membrane repolarization during action potential (GO:0086011)2.87370749
93regulation of heart rate (GO:0002027)2.86430154
94establishment of mitochondrion localization (GO:0051654)2.84906687
95regulation of membrane repolarization (GO:0060306)2.84588281
96vocalization behavior (GO:0071625)2.84491372
97regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83495008
98regulation of autophagic vacuole assembly (GO:2000785)2.83406426
99muscle contraction (GO:0006936)2.80617129
100negative regulation of myotube differentiation (GO:0010832)2.80423254
101regulation of amyloid precursor protein catabolic process (GO:1902991)2.79434016
102detection of temperature stimulus (GO:0016048)2.78955214
103mesenchyme morphogenesis (GO:0072132)2.78832777
104neuronal ion channel clustering (GO:0045161)2.76926176
105regulation of striated muscle contraction (GO:0006942)2.76479216
106striated muscle adaptation (GO:0014888)2.75135334
107regulation of ARF GTPase activity (GO:0032312)2.73476393
108negative regulation of cell size (GO:0045792)2.71520011
109regulation of glutamate receptor signaling pathway (GO:1900449)2.71087511
110synaptic vesicle docking involved in exocytosis (GO:0016081)2.70747010
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69543799
112proline transport (GO:0015824)2.69176811
113positive regulation of sodium ion transport (GO:0010765)2.68817929
114positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.67964969
115regulation of heart contraction (GO:0008016)2.67735155
116negative regulation of erythrocyte differentiation (GO:0045647)2.67517387
117muscle system process (GO:0003012)2.65743882
118regulation of ARF protein signal transduction (GO:0032012)2.65409423
119negative regulation of hormone biosynthetic process (GO:0032353)2.64443054
120establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64351804
121mitochondrion transport along microtubule (GO:0047497)2.64351804
122positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.62407445
123creatine metabolic process (GO:0006600)2.61745957
124plasma membrane repair (GO:0001778)2.60703059
125atrioventricular valve morphogenesis (GO:0003181)2.60357720
126response to parathyroid hormone (GO:0071107)2.58935024
127peptidyl-tyrosine autophosphorylation (GO:0038083)2.58913949
128protein retention in ER lumen (GO:0006621)2.58610980
129mating behavior (GO:0007617)2.57387224
130cellular response to glucagon stimulus (GO:0071377)2.57077814
131regulation of ATPase activity (GO:0043462)2.57069323
132regulation of ATP catabolic process (GO:1903289)2.57069323
133regulation of cardioblast proliferation (GO:0003264)2.56114041
134regulation of secondary heart field cardioblast proliferation (GO:0003266)2.56114041
135protein localization to synapse (GO:0035418)2.55941030
136positive regulation of sodium ion transmembrane transport (GO:1902307)2.55579219
137calcium ion-dependent exocytosis (GO:0017156)2.55204199
138regulation of heart rate by cardiac conduction (GO:0086091)2.54829151
139positive regulation of membrane potential (GO:0045838)2.53797658
140L-phenylalanine metabolic process (GO:0006558)2.51896678
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.51896678
142potassium ion import (GO:0010107)2.49000477
143dendrite morphogenesis (GO:0048813)2.48152160
144localization within membrane (GO:0051668)2.47784165
145neuron cell-cell adhesion (GO:0007158)2.46219884
146axon cargo transport (GO:0008088)2.46053294
147dopamine receptor signaling pathway (GO:0007212)2.45392581
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.45375816
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45052931
150response to dietary excess (GO:0002021)2.43861298
151cardiac muscle tissue development (GO:0048738)2.43727919
152neurotransmitter transport (GO:0006836)2.42483833
153muscle fiber development (GO:0048747)2.42036462
154protein maturation by protein folding (GO:0022417)2.41461843
155adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.41236256
156glycogen catabolic process (GO:0005980)2.40395950
157response to methylmercury (GO:0051597)2.39071108
158potassium ion homeostasis (GO:0055075)2.38777385
159long-term memory (GO:0007616)2.38624996
160muscle adaptation (GO:0043500)2.37856140
161cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.37504960
162growth hormone secretion (GO:0030252)2.36978127
163camera-type eye morphogenesis (GO:0048593)2.36481843
164regulation of synaptic plasticity (GO:0048167)2.36030525
165G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.35717613
166axon ensheathment (GO:0008366)2.35465295
167ensheathment of neurons (GO:0007272)2.35465295
168response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.34646220
169suckling behavior (GO:0001967)2.34636867
170cellular sodium ion homeostasis (GO:0006883)2.34104714
171heart valve morphogenesis (GO:0003179)2.33781437
172adrenergic receptor signaling pathway (GO:0071875)2.33745737
173nerve growth factor signaling pathway (GO:0038180)2.33355214
174multicellular organismal signaling (GO:0035637)2.33278322
175positive regulation of synapse maturation (GO:0090129)2.33250531
176regulation of neurotransmitter levels (GO:0001505)2.32872315
177urinary tract smooth muscle contraction (GO:0014848)2.32468677
178positive regulation of fatty acid oxidation (GO:0046321)2.31925302
179positive regulation of myotube differentiation (GO:0010831)2.31105265
180mannose metabolic process (GO:0006013)2.31053560
181organelle transport along microtubule (GO:0072384)2.30896506
182myelination (GO:0042552)2.30498578
183regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29999263
184positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.29969301
185membrane repolarization (GO:0086009)2.28811244
186negative regulation of axonogenesis (GO:0050771)2.27488486
187calcium-mediated signaling using intracellular calcium source (GO:0035584)2.27137136
188adenosine receptor signaling pathway (GO:0001973)2.26254717
189ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.26152425
190dendritic spine organization (GO:0097061)2.25344804
191cell communication involved in cardiac conduction (GO:0086065)2.24893189
192negative regulation of nucleotide catabolic process (GO:0030812)2.24748215
193positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.23761619
194alanine transport (GO:0032328)2.23070092
195CDP-diacylglycerol metabolic process (GO:0046341)2.22988750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01093763
2LXR_22292898_ChIP-Seq_THP-1_Human2.81719488
3EZH2_22144423_ChIP-Seq_EOC_Human2.71463516
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.71255548
5ERG_21242973_ChIP-ChIP_JURKAT_Human2.51722113
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.41703129
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38752118
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26374358
9DNAJC2_21179169_ChIP-ChIP_NT2_Human2.24297139
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19514775
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08401470
12KDM2B_26808549_Chip-Seq_K562_Human2.03981103
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02608830
14KDM2B_26808549_Chip-Seq_DND41_Human2.00587151
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99446773
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99446773
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98880105
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98654259
19ZNF263_19887448_ChIP-Seq_K562_Human1.97333906
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97016810
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96137708
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90420045
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89798505
24EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.89229020
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.87269502
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87147112
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86912766
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85824180
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83982972
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.83497354
31DROSHA_22980978_ChIP-Seq_HELA_Human1.80459686
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80401354
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78466585
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74770206
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72765076
36REST_21632747_ChIP-Seq_MESCs_Mouse1.67469840
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.64528303
38RACK7_27058665_Chip-Seq_MCF-7_Human1.63385832
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63281947
40CTCF_27219007_Chip-Seq_Bcells_Human1.60385165
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59832426
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.58348742
43P68_20966046_ChIP-Seq_HELA_Human1.58287340
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.56245447
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55783289
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54372773
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53936334
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53831155
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52869375
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.51428406
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50610196
52CREB1_26743006_Chip-Seq_LNCaP_Human1.46830412
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.46333255
54SMC4_20622854_ChIP-Seq_HELA_Human1.46087079
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45617537
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.44775074
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.44003711
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42453641
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40788995
60VDR_21846776_ChIP-Seq_THP-1_Human1.39402563
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37638752
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.36762244
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.36272838
64TET1_21490601_ChIP-Seq_MESCs_Mouse1.36047262
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35152507
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34932582
67MYC_22102868_ChIP-Seq_BL_Human1.34190970
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34041867
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.33374244
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.31801201
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31455813
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30003491
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29906024
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28325207
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27869269
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.27706070
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27635022
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27283686
79SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25996199
80SA1_27219007_Chip-Seq_Bcells_Human1.25816326
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.25650389
82BCOR_27268052_Chip-Seq_Bcells_Human1.24174822
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23722450
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.22727722
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21750282
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20817010
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19728884
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.19152076
89SMC3_22415368_ChIP-Seq_MEFs_Mouse1.17688898
90CTCF_20526341_ChIP-Seq_ESCs_Human1.17301856
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16814342
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16206947
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.14782298
94TCF7_22412390_ChIP-Seq_EML_Mouse1.13353305
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.13024750
96TBX20_22328084_ChIP-Seq_HEART_Mouse1.13024750
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.12125645
98BCL6_27268052_Chip-Seq_Bcells_Human1.11220196
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.11111009
100TP63_22573176_ChIP-Seq_HFKS_Human1.11029849
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09558331
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08720617
103MYC_27129775_Chip-Seq_CORNEA_Mouse1.08375788
104GATA1_19941826_ChIP-Seq_K562_Human1.08216098
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.07671899
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06728315
107OCT4_19829295_ChIP-Seq_ESCs_Human1.05601165
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04700616
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.03507327
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02853003
111KLF4_19829295_ChIP-Seq_ESCs_Human1.02053232
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00534144
113TP63_17297297_ChIP-ChIP_HaCaT_Human0.99586526
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99291985
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.99047352
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.97425511
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97127013
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97090130
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.97006556
120PHF8_20622854_ChIP-Seq_HELA_Human0.95546727
121E2F1_20622854_ChIP-Seq_HELA_Human0.93129423
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91353620
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.91236073
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89886685
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88394474
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88348796
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87700249
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86240839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.24673857
2MP0004084_abnormal_cardiac_muscle3.88070415
3MP0004036_abnormal_muscle_relaxation3.69123495
4MP0003329_amyloid_beta_deposits3.42599600
5MP0004270_analgesia3.36916111
6MP0004858_abnormal_nervous_system3.17917378
7MP0003635_abnormal_synaptic_transmissio3.14130699
8MP0003646_muscle_fatigue3.01091155
9MP0004510_myositis2.95210937
10MP0008775_abnormal_heart_ventricle2.76919786
11MP0003880_abnormal_central_pattern2.74418322
12MP0002909_abnormal_adrenal_gland2.57359073
13MP0002972_abnormal_cardiac_muscle2.49921007
14MP0002064_seizures2.46024794
15MP0004215_abnormal_myocardial_fiber2.41627918
16MP0005620_abnormal_muscle_contractility2.38645229
17MP0003283_abnormal_digestive_organ2.28801688
18MP0009745_abnormal_behavioral_response2.24245455
19MP0002063_abnormal_learning/memory/cond2.22926539
20MP0009840_abnormal_foam_cell2.20931596
21MP0002733_abnormal_thermal_nociception2.17478881
22MP0001968_abnormal_touch/_nociception2.12268426
23MP0001485_abnormal_pinna_reflex2.11437710
24MP0001348_abnormal_lacrimal_gland2.07094528
25MP0002822_catalepsy2.04240912
26MP0002106_abnormal_muscle_physiology2.01468187
27MP0002272_abnormal_nervous_system1.99119130
28MP0009780_abnormal_chondrocyte_physiolo1.97251274
29MP0004087_abnormal_muscle_fiber1.94628988
30MP0002734_abnormal_mechanical_nocicepti1.90297201
31MP0000749_muscle_degeneration1.89458376
32MP0005083_abnormal_biliary_tract1.88675442
33MP0001970_abnormal_pain_threshold1.86473740
34MP0000013_abnormal_adipose_tissue1.83381160
35MP0000920_abnormal_myelination1.78452212
36MP0000604_amyloidosis1.78145667
37MP0002572_abnormal_emotion/affect_behav1.78012818
38MP0005423_abnormal_somatic_nervous1.77991819
39MP0000750_abnormal_muscle_regeneration1.77976881
40MP0000955_abnormal_spinal_cord1.73080898
41MP0008569_lethality_at_weaning1.70283277
42MP0002249_abnormal_larynx_morphology1.69174301
43MP0005369_muscle_phenotype1.68592061
44MP0000751_myopathy1.68465525
45MP0004885_abnormal_endolymph1.67879140
46MP0002735_abnormal_chemical_nociception1.67668125
47MP0008961_abnormal_basal_metabolism1.66639262
48MP0009046_muscle_twitch1.58687519
49MP0002736_abnormal_nociception_after1.56819662
50MP0000759_abnormal_skeletal_muscle1.55697765
51MP0002127_abnormal_cardiovascular_syste1.55338732
52MP0004811_abnormal_neuron_physiology1.54538787
53MP0000747_muscle_weakness1.52668025
54MP0001544_abnormal_cardiovascular_syste1.49673892
55MP0005385_cardiovascular_system_phenoty1.49673892
56MP0003634_abnormal_glial_cell1.49364445
57MP0000003_abnormal_adipose_tissue1.46720419
58MP0001486_abnormal_startle_reflex1.45616178
59MP0010630_abnormal_cardiac_muscle1.43529096
60MP0003172_abnormal_lysosome_physiology1.43453791
61MP0003279_aneurysm1.41949385
62MP0003633_abnormal_nervous_system1.36693314
63MP0002837_dystrophic_cardiac_calcinosis1.36467379
64MP0004742_abnormal_vestibular_system1.36098881
65MP0002066_abnormal_motor_capabilities/c1.30136955
66MP0006138_congestive_heart_failure1.28852027
67MP0002067_abnormal_sensory_capabilities1.28851395
68MP0002254_reproductive_system_inflammat1.28753010
69MP0009384_cardiac_valve_regurgitation1.28108437
70MP0002184_abnormal_innervation1.26398786
71MP0004142_abnormal_muscle_tone1.23563132
72MP0003195_calcinosis1.22836274
73MP0003075_altered_response_to1.22045735
74MP0000733_abnormal_muscle_development1.21610496
75MP0005058_abnormal_lysosome_morphology1.21559112
76MP0003122_maternal_imprinting1.21038014
77MP0005623_abnormal_meninges_morphology1.21009351
78MP0000778_abnormal_nervous_system1.20795938
79MP0004043_abnormal_pH_regulation1.20559973
80MP0001440_abnormal_grooming_behavior1.18724266
81MP0002882_abnormal_neuron_morphology1.16378733
82MP0005645_abnormal_hypothalamus_physiol1.16137633
83MP0003690_abnormal_glial_cell1.14785756
84MP0004145_abnormal_muscle_electrophysio1.12471983
85MP0008874_decreased_physiological_sensi1.12329894
86MP0006276_abnormal_autonomic_nervous1.09415348
87MP0004924_abnormal_behavior1.07017053
88MP0005386_behavior/neurological_phenoty1.07017053
89MP0002557_abnormal_social/conspecific_i1.06344270
90MP0005451_abnormal_body_composition1.06049410
91MP0004233_abnormal_muscle_weight1.03659697
92MP0003631_nervous_system_phenotype1.03504230
93MP0010030_abnormal_orbit_morphology1.03504116
94MP0004130_abnormal_muscle_cell1.00805059
95MP0005584_abnormal_enzyme/coenzyme_acti1.00334977
96MP0003705_abnormal_hypodermis_morpholog0.97939092
97MP0003137_abnormal_impulse_conducting0.96827982
98MP0002089_abnormal_postnatal_growth/wei0.95979586
99MP0002108_abnormal_muscle_morphology0.95435006
100MP0000026_abnormal_inner_ear0.95012260
101MP0002653_abnormal_ependyma_morphology0.93217963
102MP0003879_abnormal_hair_cell0.92819749
103MP0002069_abnormal_eating/drinking_beha0.92603269
104MP0001501_abnormal_sleep_pattern0.91599831
105MP0004484_altered_response_of0.90891240
106MP0002332_abnormal_exercise_endurance0.90759077
107MP0009379_abnormal_foot_pigmentation0.89739166
108MP0000767_abnormal_smooth_muscle0.89605295
109MP0002152_abnormal_brain_morphology0.88821880
110MP0002229_neurodegeneration0.88606544
111MP0001299_abnormal_eye_distance/0.87923436
112MP0001529_abnormal_vocalization0.87686180
113MP0005167_abnormal_blood-brain_barrier0.85301585
114MP0005535_abnormal_body_temperature0.84788377
115MP0001502_abnormal_circadian_rhythm0.82586085
116MP0002118_abnormal_lipid_homeostasis0.82122795
117MP0001905_abnormal_dopamine_level0.81929072
118MP0005332_abnormal_amino_acid0.81127677
119MP0002269_muscular_atrophy0.80164774
120MP0005375_adipose_tissue_phenotype0.79874727
121MP0005503_abnormal_tendon_morphology0.79478687
122MP0001765_abnormal_ion_homeostasis0.79349756
123MP0000538_abnormal_urinary_bladder0.77256504
124MP0000230_abnormal_systemic_arterial0.74737409
125MP0004133_heterotaxia0.74722380
126MP0000534_abnormal_ureter_morphology0.72972736
127MP0003942_abnormal_urinary_system0.72972060
128MP0003656_abnormal_erythrocyte_physiolo0.72855636
129MP0001944_abnormal_pancreas_morphology0.72670514
130MP0001963_abnormal_hearing_physiology0.72355720
131MP0004085_abnormal_heartbeat0.71738081
132MP0003300_gastrointestinal_ulcer0.71397778
133MP0003632_abnormal_nervous_system0.71170949
134MP0000678_abnormal_parathyroid_gland0.71133042
135MP0002078_abnormal_glucose_homeostasis0.70369451
136MP0001664_abnormal_digestion0.70018423
137MP0000639_abnormal_adrenal_gland0.68633815
138MP0008872_abnormal_physiological_respon0.68595292
139MP0000266_abnormal_heart_morphology0.68078836
140MP0000462_abnormal_digestive_system0.67918299
141MP0005330_cardiomyopathy0.66332596
142MP0010329_abnormal_lipoprotein_level0.66059029
143MP0005595_abnormal_vascular_smooth0.65903461
144MP0002876_abnormal_thyroid_physiology0.65519092
145MP0009250_abnormal_appendicular_skeleto0.64061649
146MP0003123_paternal_imprinting0.62252564
147MP0003045_fibrosis0.60489340
148MP0005448_abnormal_energy_balance0.59523094
149MP0005248_abnormal_Harderian_gland0.58298128
150MP0005381_digestive/alimentary_phenotyp0.56820452
151MP0002971_abnormal_brown_adipose0.55724807
152MP0009053_abnormal_anal_canal0.54758468
153MP0000537_abnormal_urethra_morphology0.53637254
154MP0002933_joint_inflammation0.52462340

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.32667212
2Ventricular tachycardia (HP:0004756)4.80543344
3Type 1 muscle fiber predominance (HP:0003803)4.59480382
4Atrial fibrillation (HP:0005110)4.42035482
5Supranuclear gaze palsy (HP:0000605)4.33486624
6Patent foramen ovale (HP:0001655)4.16808280
7Muscle fiber inclusion bodies (HP:0100299)4.06459172
8Neurofibrillary tangles (HP:0002185)4.04436491
9Muscle hypertrophy of the lower extremities (HP:0008968)4.02956281
10Primary atrial arrhythmia (HP:0001692)4.00581672
11Supraventricular tachycardia (HP:0004755)3.88949424
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.82154757
13Calf muscle hypertrophy (HP:0008981)3.80213672
14Supraventricular arrhythmia (HP:0005115)3.79525597
15Exercise-induced myalgia (HP:0003738)3.73291847
16Syncope (HP:0001279)3.72516121
17Nemaline bodies (HP:0003798)3.68317303
18Ulnar deviation of the wrist (HP:0003049)3.63576175
19Cerebral inclusion bodies (HP:0100314)3.56190199
20Hip contracture (HP:0003273)3.48191389
21Round ear (HP:0100830)3.48057689
22Subaortic stenosis (HP:0001682)3.44166056
23Abnormality of the left ventricular outflow tract (HP:0011103)3.44166056
24Visual hallucinations (HP:0002367)3.40955014
25Distal arthrogryposis (HP:0005684)3.39043899
26Fetal akinesia sequence (HP:0001989)3.38320890
27Muscle fiber splitting (HP:0003555)3.37541567
28Ventricular arrhythmia (HP:0004308)3.34609940
29Abnormality of the calf musculature (HP:0001430)3.30893787
30Hypoplastic ischia (HP:0003175)3.30545667
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.29835044
32Hyporeflexia of lower limbs (HP:0002600)3.25475815
33Ankle clonus (HP:0011448)3.20046540
34Insomnia (HP:0100785)3.11244719
35Prolonged QT interval (HP:0001657)3.09772810
36Depression (HP:0000716)3.01019213
37Hypercortisolism (HP:0001578)2.99941262
38Lipoatrophy (HP:0100578)2.98188931
39Abnormal EKG (HP:0003115)2.97094722
40Centrally nucleated skeletal muscle fibers (HP:0003687)2.94817671
41Pheochromocytoma (HP:0002666)2.88689149
42Heart block (HP:0012722)2.86719564
43EMG: myopathic abnormalities (HP:0003458)2.85322384
44Abnormality of liposaccharide metabolism (HP:0010968)2.83502811
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.83502811
46Abnormality of glycolipid metabolism (HP:0010969)2.83502811
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82331797
48Achilles tendon contracture (HP:0001771)2.82154964
49Abnormality of the ischium (HP:0003174)2.81551656
50Congenital malformation of the right heart (HP:0011723)2.80140492
51Double outlet right ventricle (HP:0001719)2.80140492
52Megalencephaly (HP:0001355)2.79922647
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79528655
54Abnormal atrioventricular conduction (HP:0005150)2.77278231
55Action tremor (HP:0002345)2.75493959
56Abnormality of the Achilles tendon (HP:0005109)2.73403648
57Left ventricular hypertrophy (HP:0001712)2.72327046
58Distal lower limb muscle weakness (HP:0009053)2.70394507
59Myopathic facies (HP:0002058)2.68824119
60Focal motor seizures (HP:0011153)2.65318411
61Dilated cardiomyopathy (HP:0001644)2.61769991
62Torticollis (HP:0000473)2.58790334
63Anxiety (HP:0000739)2.58621246
64Limited hip movement (HP:0008800)2.53734187
65Bradycardia (HP:0001662)2.53275674
66Focal seizures (HP:0007359)2.53122467
67Neuroendocrine neoplasm (HP:0100634)2.49407198
68Dysostosis multiplex (HP:0000943)2.48639100
69Abnormality of the aortic arch (HP:0012303)2.48013169
70Exercise-induced muscle cramps (HP:0003710)2.47349582
71Upper limb amyotrophy (HP:0009129)2.47229264
72Distal upper limb amyotrophy (HP:0007149)2.47229264
73Spastic gait (HP:0002064)2.45175278
74Focal dystonia (HP:0004373)2.41337058
75Absent phalangeal crease (HP:0006109)2.39625610
76Abnormality of the pubic bones (HP:0003172)2.39199185
77Craniofacial dystonia (HP:0012179)2.38334650
78Turricephaly (HP:0000262)2.37864299
79Rapidly progressive (HP:0003678)2.33587944
80Dysmetria (HP:0001310)2.33487278
81Agitation (HP:0000713)2.32861707
82Decreased circulating renin level (HP:0003351)2.32387197
83Annular pancreas (HP:0001734)2.31961167
84Ventricular fibrillation (HP:0001663)2.27958853
85Urinary urgency (HP:0000012)2.27759088
86Hyperparathyroidism (HP:0000843)2.27468871
87Hyperacusis (HP:0010780)2.21853620
88Right ventricular cardiomyopathy (HP:0011663)2.17454371
89Intention tremor (HP:0002080)2.17307140
90Peripheral hypomyelination (HP:0007182)2.17050322
91Increased variability in muscle fiber diameter (HP:0003557)2.16774524
92Papilledema (HP:0001085)2.16256402
93Ketoacidosis (HP:0001993)2.14233712
94Abnormality of the lower motor neuron (HP:0002366)2.13918543
95Postural instability (HP:0002172)2.11467819
96Termporal pattern (HP:0011008)2.07788516
97Insidious onset (HP:0003587)2.07788516
98Neoplasm of the heart (HP:0100544)2.07773085
99Neuronal loss in central nervous system (HP:0002529)2.06676702
100Broad metatarsal (HP:0001783)2.06540004
101Hand muscle atrophy (HP:0009130)2.04957028
102EMG: neuropathic changes (HP:0003445)2.04787708
103Generalized muscle weakness (HP:0003324)2.04010671
104Bundle branch block (HP:0011710)2.03557224
105Abnormal eating behavior (HP:0100738)2.03404756
106Calcaneovalgus deformity (HP:0001848)2.03402459
107Neoplasm of the peripheral nervous system (HP:0100007)2.03318219
108Abnormality of the corticospinal tract (HP:0002492)2.02841477
109Myotonia (HP:0002486)2.01727507
110Psychosis (HP:0000709)2.01560647
111Growth hormone excess (HP:0000845)2.00937317
112Athetosis (HP:0002305)2.00454529
113Scanning speech (HP:0002168)2.00284292
114Myoglobinuria (HP:0002913)1.99569930
115Abnormality of skeletal muscle fiber size (HP:0012084)1.99321231
116Deep palmar crease (HP:0006191)1.98533403
117Mildly elevated creatine phosphokinase (HP:0008180)1.98499695
118Aplasia of the musculature (HP:0100854)1.97881289
119Rigidity (HP:0002063)1.95213559
120Metatarsus adductus (HP:0001840)1.94459433
121Diminished motivation (HP:0000745)1.94213171
122Hyperkalemia (HP:0002153)1.93879983
123Menstrual irregularities (HP:0000858)1.93037825
124Large for gestational age (HP:0001520)1.92222111
125Late onset (HP:0003584)1.91536115
126Bulbar palsy (HP:0001283)1.90904135
127Ketosis (HP:0001946)1.90594422
128Impaired social interactions (HP:0000735)1.88027079
129Abnormal social behavior (HP:0012433)1.88027079
130Abnormality of polysaccharide metabolism (HP:0011012)1.87863548
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87863548
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87863548
133Cerebral hypomyelination (HP:0006808)1.86530692
134Clonus (HP:0002169)1.86298569
135Delusions (HP:0000746)1.86238410
136Difficulty climbing stairs (HP:0003551)1.86140029
137Truncus arteriosus (HP:0001660)1.85423206
138Progressive muscle weakness (HP:0003323)1.84906785
139Morphological abnormality of the middle ear (HP:0008609)1.84495223
140Loss of speech (HP:0002371)1.84278191
141Hypoventilation (HP:0002791)1.84237598
142Increased connective tissue (HP:0009025)1.84164026
143Abnormality of the neuromuscular junction (HP:0003398)1.84023318
144Fatigable weakness (HP:0003473)1.84023318
145Lymphangioma (HP:0100764)1.83620299
146Adrenal overactivity (HP:0002717)1.83136824
147Overriding aorta (HP:0002623)1.83105128
148Hyperthyroidism (HP:0000836)1.82817141
149Urinary glycosaminoglycan excretion (HP:0003541)1.82236826
150Mucopolysacchariduria (HP:0008155)1.82236826
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.81544694
152Hammertoe (HP:0001765)1.80766748
153Apathy (HP:0000741)1.80564634
154Nonprogressive disorder (HP:0003680)1.78878862
155Impaired vibration sensation in the lower limbs (HP:0002166)1.76931902
156Asymmetric septal hypertrophy (HP:0001670)1.76268538
157Hypoplastic heart (HP:0001961)1.76213251
158Frequent falls (HP:0002359)1.75966113
159Obstructive sleep apnea (HP:0002870)1.75533688
160Bronchomalacia (HP:0002780)1.75438048
161Spastic paraparesis (HP:0002313)1.74722646
162Delayed CNS myelination (HP:0002188)1.74432745
163Deformed tarsal bones (HP:0008119)1.74407417
164Amyotrophic lateral sclerosis (HP:0007354)1.74395934
165Gout (HP:0001997)1.73313550
166Progressive neurologic deterioration (HP:0002344)1.73293078
167Abnormal finger flexion creases (HP:0006143)1.72476456
168Generalized tonic-clonic seizures (HP:0002069)1.72146239
169Mesangial abnormality (HP:0001966)1.72065119
170Sudden death (HP:0001699)1.71935405
171Amblyopia (HP:0000646)1.71165542
172Poor eye contact (HP:0000817)1.70828766
173Onion bulb formation (HP:0003383)1.70543982
174Congenital glaucoma (HP:0001087)1.70385798
175Bilateral microphthalmos (HP:0007633)1.70267176
176Weak cry (HP:0001612)1.69861563
177Back pain (HP:0003418)1.69301118
178Akinesia (HP:0002304)1.68989438
179Absence seizures (HP:0002121)1.68771352
180Pointed chin (HP:0000307)1.68473055
181Hypercalcemia (HP:0003072)1.67965565
182Restlessness (HP:0000711)1.67836928
183Hemiplegia (HP:0002301)1.67460241
184Joint stiffness (HP:0001387)1.67243393
185Anosmia (HP:0000458)1.67110808
186Lower limb muscle weakness (HP:0007340)1.66688497
187Rhabdomyolysis (HP:0003201)1.66104467
188Muscle stiffness (HP:0003552)1.64291741
189Stridor (HP:0010307)1.62420175
190Bell-shaped thorax (HP:0001591)1.60552665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.17167714
2TRIB33.63043278
3NTRK12.74867605
4KSR22.56309433
5MAP3K92.53035449
6NTRK32.41025614
7WNK32.37486776
8ERN12.23981941
9TTN2.22013679
10PAK62.20555670
11PRKD32.19437092
12CDK192.17842861
13UHMK11.97319865
14ICK1.91915102
15PKN21.90829967
16EPHA41.86287749
17FRK1.84136584
18TYRO31.83916080
19DAPK21.72435268
20MINK11.69638942
21ARAF1.66341684
22BCKDK1.65043686
23NEK21.57348864
24TAOK11.54210464
25MARK11.49967454
26CAMKK11.48155163
27MAP3K111.46143982
28WNK41.43112586
29SCYL21.42507659
30PHKG21.41191906
31PHKG11.41191906
32TESK21.31392335
33NTRK21.29790128
34LIMK11.28331537
35EPHB11.28247716
36MAPK121.27458680
37CDK51.25920654
38MAP3K11.24535860
39MAP3K21.24527702
40RET1.22870347
41EPHB21.22489435
42STK391.19647098
43MAPKAPK31.18754035
44LMTK21.17863848
45MUSK1.16644893
46MAPK151.15968197
47GRK71.15804222
48CASK1.15082949
49PRPF4B1.13465060
50EEF2K1.09301023
51PDGFRA1.08538919
52FLT31.08304033
53PAK31.07683142
54DAPK31.03592003
55MAP2K21.02289823
56TRPM71.00646710
57PRKCH1.00550979
58ALK1.00217801
59CDC42BPA1.00072426
60BMX0.98780009
61MAP2K60.97025064
62CDK140.96531690
63PDPK10.96202264
64LATS20.92173936
65RPS6KA20.91786049
66HIPK20.89722834
67MAP3K100.89566816
68OXSR10.88968524
69MARK20.87485742
70PINK10.86884740
71PTK20.86744861
72TESK10.86451723
73CDK150.86267271
74EPHA20.86023705
75SIK10.85619032
76MAP2K40.84818789
77CDK11A0.83004774
78KSR10.82822755
79CAMK40.81323034
80CAMK1D0.80098300
81CDK180.79474564
82FES0.77291554
83DAPK10.77190545
84IRAK30.77079876
85DDR20.73434966
86PDK10.71667861
87ILK0.71531745
88MAPKAPK50.70756079
89GRK50.70223617
90PRKD20.70126218
91PRKD10.69683629
92MAP3K40.69611984
93DMPK0.69403353
94LRRK20.69005676
95PRKAA20.68743317
96SIK20.67664125
97ROCK20.66987855
98STK380.65508263
99RIPK10.64647015
100PRKCG0.64409402
101WNK10.64195783
102CAMK1G0.64077253
103MAP3K70.63071575
104RAF10.61234461
105CAMK10.60946127
106MET0.57929165
107RPS6KA60.57491978
108CSNK1G20.56644481
109ABL20.55435381
110CAMK2G0.55266275
111PIK3CA0.53643547
112PRKAA10.53390236
113KDR0.53189917
114EPHA30.52841071
115MTOR0.51880416
116PTK60.51605483
117GRK60.51187189
118CAMK2D0.51131236
119RPS6KL10.50458517
120RPS6KC10.50458517
121DYRK1B0.50392352
122MAPK40.49749599
123STK110.49358774
124CAMK2B0.48907335
125FGFR40.48902082
126ROCK10.48804830
127TNIK0.48067435
128PRKCZ0.46841047
129FYN0.46239062
130ACVR1B0.44743498
131MAP2K10.43874518
132TNK20.43741935
133PRKG20.43667189
134SMG10.43456334
135PKN10.43389702
136BRAF0.42441270
137GRK10.42280538
138MAPK70.41803015
139TLK10.41773681
140CSNK1G30.41713456
141MYLK0.41132036
142CAMK2A0.40394580
143ADRBK20.40048012
144INSRR0.36112428
145TAOK20.32858101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.10588468
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.05089458
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.95517670
4Synaptic vesicle cycle_Homo sapiens_hsa047212.54764779
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.31736846
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.22436060
7Insulin secretion_Homo sapiens_hsa049111.79751729
8GABAergic synapse_Homo sapiens_hsa047271.76742847
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72762487
10Olfactory transduction_Homo sapiens_hsa047401.66198175
11Long-term potentiation_Homo sapiens_hsa047201.64178860
12Circadian entrainment_Homo sapiens_hsa047131.62395868
13Cocaine addiction_Homo sapiens_hsa050301.61851250
14Dopaminergic synapse_Homo sapiens_hsa047281.57470044
15Amphetamine addiction_Homo sapiens_hsa050311.56677583
16Gastric acid secretion_Homo sapiens_hsa049711.53409788
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50862134
18Glutamatergic synapse_Homo sapiens_hsa047241.50546742
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48410786
20Salivary secretion_Homo sapiens_hsa049701.45952162
21Other glycan degradation_Homo sapiens_hsa005111.43741719
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38637769
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37794605
24Morphine addiction_Homo sapiens_hsa050321.33450102
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.29858168
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27755575
27Cholinergic synapse_Homo sapiens_hsa047251.26060768
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25911756
29Gap junction_Homo sapiens_hsa045401.25542721
30Fructose and mannose metabolism_Homo sapiens_hsa000511.21421191
31Bile secretion_Homo sapiens_hsa049761.19691744
32VEGF signaling pathway_Homo sapiens_hsa043701.18783233
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18650136
34Protein digestion and absorption_Homo sapiens_hsa049741.16984241
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16829869
36Vibrio cholerae infection_Homo sapiens_hsa051101.14508524
37Cardiac muscle contraction_Homo sapiens_hsa042601.14048755
38Tight junction_Homo sapiens_hsa045301.11244726
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11167335
40Estrogen signaling pathway_Homo sapiens_hsa049151.10687463
41Sulfur relay system_Homo sapiens_hsa041221.10464119
42Prion diseases_Homo sapiens_hsa050201.10074951
43Galactose metabolism_Homo sapiens_hsa000521.05848021
44Long-term depression_Homo sapiens_hsa047301.05702396
45Pancreatic secretion_Homo sapiens_hsa049721.05565561
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05382443
47Glioma_Homo sapiens_hsa052141.01197666
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00956055
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00827776
50Butanoate metabolism_Homo sapiens_hsa006501.00638753
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00329435
52GnRH signaling pathway_Homo sapiens_hsa049121.00263220
53Arginine biosynthesis_Homo sapiens_hsa002200.99745693
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99161712
55Melanogenesis_Homo sapiens_hsa049160.99095199
56Oxytocin signaling pathway_Homo sapiens_hsa049210.98257298
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.97229958
58Nicotine addiction_Homo sapiens_hsa050330.96445057
59Notch signaling pathway_Homo sapiens_hsa043300.96273968
60Renin secretion_Homo sapiens_hsa049240.94678925
61PPAR signaling pathway_Homo sapiens_hsa033200.94377869
62ECM-receptor interaction_Homo sapiens_hsa045120.90961830
63Ovarian steroidogenesis_Homo sapiens_hsa049130.89776467
64Arginine and proline metabolism_Homo sapiens_hsa003300.89361957
65Lysosome_Homo sapiens_hsa041420.87768877
66Insulin resistance_Homo sapiens_hsa049310.87040601
67Axon guidance_Homo sapiens_hsa043600.86563019
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.84418695
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84028962
70Endocytosis_Homo sapiens_hsa041440.83169943
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80811510
72Focal adhesion_Homo sapiens_hsa045100.80705402
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80361750
74Parkinsons disease_Homo sapiens_hsa050120.79968385
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79563372
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79513631
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.78016674
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77952679
79Type II diabetes mellitus_Homo sapiens_hsa049300.77550006
80Thyroid hormone synthesis_Homo sapiens_hsa049180.77202906
81cAMP signaling pathway_Homo sapiens_hsa040240.77010978
82ErbB signaling pathway_Homo sapiens_hsa040120.76716638
83Mineral absorption_Homo sapiens_hsa049780.76364406
84Insulin signaling pathway_Homo sapiens_hsa049100.76259460
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.75149912
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.74821886
87Bladder cancer_Homo sapiens_hsa052190.74790022
88ABC transporters_Homo sapiens_hsa020100.73955487
89Folate biosynthesis_Homo sapiens_hsa007900.72193211
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72082530
91Basal cell carcinoma_Homo sapiens_hsa052170.72052823
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.71849363
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71277318
94Calcium signaling pathway_Homo sapiens_hsa040200.70502912
95Renal cell carcinoma_Homo sapiens_hsa052110.69698347
96Fatty acid metabolism_Homo sapiens_hsa012120.68309160
97Non-small cell lung cancer_Homo sapiens_hsa052230.68173059
98Histidine metabolism_Homo sapiens_hsa003400.67575691
99Alzheimers disease_Homo sapiens_hsa050100.67383060
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66971481
101Amoebiasis_Homo sapiens_hsa051460.66541122
102Serotonergic synapse_Homo sapiens_hsa047260.65746073
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64699495
104Taste transduction_Homo sapiens_hsa047420.63890778
105Collecting duct acid secretion_Homo sapiens_hsa049660.63391501
106Linoleic acid metabolism_Homo sapiens_hsa005910.62413960
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62345390
108Dorso-ventral axis formation_Homo sapiens_hsa043200.61260176
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.60936556
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.60366991
111AMPK signaling pathway_Homo sapiens_hsa041520.60020000
112Choline metabolism in cancer_Homo sapiens_hsa052310.58449589
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.57785114
114Starch and sucrose metabolism_Homo sapiens_hsa005000.57308341
115Oxidative phosphorylation_Homo sapiens_hsa001900.57151680
116MAPK signaling pathway_Homo sapiens_hsa040100.56988571
117Biosynthesis of amino acids_Homo sapiens_hsa012300.55728057
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.54570208
119Glucagon signaling pathway_Homo sapiens_hsa049220.54205473
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54127531
121Sulfur metabolism_Homo sapiens_hsa009200.53681218
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52412341
123Dilated cardiomyopathy_Homo sapiens_hsa054140.52057286
124Ether lipid metabolism_Homo sapiens_hsa005650.51007948
125Phenylalanine metabolism_Homo sapiens_hsa003600.50101871
126Fatty acid elongation_Homo sapiens_hsa000620.48668575
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47857289
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47503707
129Carbon metabolism_Homo sapiens_hsa012000.46963118
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46844428
131Hedgehog signaling pathway_Homo sapiens_hsa043400.46143477
132mTOR signaling pathway_Homo sapiens_hsa041500.45422531
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44953164
134Fatty acid degradation_Homo sapiens_hsa000710.43691638
135Tryptophan metabolism_Homo sapiens_hsa003800.43578912
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43326742
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42452998
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40894122
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39442503
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.38696237

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