EMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.62453467
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.02066088
3ATP synthesis coupled proton transport (GO:0015986)8.02066088
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.40827218
5respiratory electron transport chain (GO:0022904)6.78638269
6electron transport chain (GO:0022900)6.62845042
7chaperone-mediated protein transport (GO:0072321)5.49280534
8protein neddylation (GO:0045116)5.46849082
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.91999287
10NADH dehydrogenase complex assembly (GO:0010257)4.91999287
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.91999287
12protein complex biogenesis (GO:0070271)4.86424673
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.70581553
14mitochondrial respiratory chain complex assembly (GO:0033108)4.65803068
15fatty acid elongation (GO:0030497)4.47085297
16hydrogen ion transmembrane transport (GO:1902600)4.25581490
17oxidative phosphorylation (GO:0006119)4.24960282
18ATP biosynthetic process (GO:0006754)4.18674878
19negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.96942291
20purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.94050529
21purine nucleoside triphosphate biosynthetic process (GO:0009145)3.90779604
22proton transport (GO:0015992)3.90720353
23cullin deneddylation (GO:0010388)3.88496153
24hydrogen transport (GO:0006818)3.82197488
25energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.74029518
26ATP hydrolysis coupled proton transport (GO:0015991)3.74029518
27regulation of cell communication by electrical coupling (GO:0010649)3.71331145
28tricarboxylic acid cycle (GO:0006099)3.70199032
29long-chain fatty acid biosynthetic process (GO:0042759)3.64411679
30water-soluble vitamin biosynthetic process (GO:0042364)3.62512146
31platelet dense granule organization (GO:0060155)3.60064357
32CENP-A containing nucleosome assembly (GO:0034080)3.57457360
33substantia nigra development (GO:0021762)3.56839703
34inner mitochondrial membrane organization (GO:0007007)3.46314579
35chromatin remodeling at centromere (GO:0031055)3.46235845
36respiratory chain complex IV assembly (GO:0008535)3.45260273
37regulation of cellular amino acid metabolic process (GO:0006521)3.43637105
38protein deneddylation (GO:0000338)3.41465927
39heart process (GO:0003015)3.41390737
40heart contraction (GO:0060047)3.41390737
41lactate metabolic process (GO:0006089)3.40956488
42ribonucleoside triphosphate biosynthetic process (GO:0009201)3.40190573
43central nervous system myelination (GO:0022010)3.38494494
44axon ensheathment in central nervous system (GO:0032291)3.38494494
45synapsis (GO:0007129)3.37488090
46cytochrome complex assembly (GO:0017004)3.33212771
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.31667602
48proteasome assembly (GO:0043248)3.31014783
49protein targeting to mitochondrion (GO:0006626)3.28335601
50DNA double-strand break processing (GO:0000729)3.26388213
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22938929
52positive regulation of mitochondrial fission (GO:0090141)3.21825971
53phagosome maturation (GO:0090382)3.21772114
54mitochondrial transport (GO:0006839)3.21432863
55nucleoside triphosphate biosynthetic process (GO:0009142)3.17313680
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16877102
57histone exchange (GO:0043486)3.16179795
58establishment of protein localization to mitochondrion (GO:0072655)3.16134744
59aerobic respiration (GO:0009060)3.15063141
60regulation of acyl-CoA biosynthetic process (GO:0050812)3.12901582
61protein localization to mitochondrion (GO:0070585)3.09020160
62GTP biosynthetic process (GO:0006183)3.07865309
63transferrin transport (GO:0033572)3.04761674
64regulation of relaxation of muscle (GO:1901077)3.04206169
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02784222
66termination of RNA polymerase III transcription (GO:0006386)3.00134293
67transcription elongation from RNA polymerase III promoter (GO:0006385)3.00134293
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98859212
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97784612
70regulation of mitochondrial translation (GO:0070129)2.96746873
71ubiquinone metabolic process (GO:0006743)2.95182877
72establishment of integrated proviral latency (GO:0075713)2.94838924
73peptidyl-histidine modification (GO:0018202)2.94548883
74aldehyde catabolic process (GO:0046185)2.93109653
75regulation of coenzyme metabolic process (GO:0051196)2.91624241
76regulation of cofactor metabolic process (GO:0051193)2.91624241
77ubiquinone biosynthetic process (GO:0006744)2.91331530
78quinone biosynthetic process (GO:1901663)2.91331530
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91310689
80ferric iron transport (GO:0015682)2.89322894
81trivalent inorganic cation transport (GO:0072512)2.89322894
82branched-chain amino acid catabolic process (GO:0009083)2.84851888
83calcium-mediated signaling using intracellular calcium source (GO:0035584)2.82698016
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82371732
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82371732
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82086233
87negative regulation of ligase activity (GO:0051352)2.82086233
88nucleoside diphosphate phosphorylation (GO:0006165)2.80491310
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80464099
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80464099
91protein localization to cilium (GO:0061512)2.80231142
92cholesterol biosynthetic process (GO:0006695)2.78753034
93RNA capping (GO:0036260)2.78111282
947-methylguanosine RNA capping (GO:0009452)2.78111282
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76794714
96metaphase plate congression (GO:0051310)2.76590746
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75343895
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75343895
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75343895
100regulation of axon regeneration (GO:0048679)2.74782639
101regulation of neuron projection regeneration (GO:0070570)2.74782639
102positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74637751
103regulation of hexokinase activity (GO:1903299)2.74265642
104regulation of glucokinase activity (GO:0033131)2.74265642
105regulation of oxidative phosphorylation (GO:0002082)2.73413756
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.72563786
107regulation of cellular amine metabolic process (GO:0033238)2.72246789
108NADH metabolic process (GO:0006734)2.71449207
109intracellular protein transmembrane import (GO:0044743)2.71261199
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.70670163
111anterograde synaptic vesicle transport (GO:0048490)2.70644182
112histone mRNA metabolic process (GO:0008334)2.70302655
113regulation of cellular respiration (GO:0043457)2.70235526
114mitotic metaphase plate congression (GO:0007080)2.70006562
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69381279
116response to redox state (GO:0051775)2.69198549
117antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.68312880
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67551543
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.66069832
120exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65762947
121regulation of mitochondrial fission (GO:0090140)2.65543807
122sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65021245
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64968111
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.64968111
125cellular respiration (GO:0045333)2.63250704
126signal peptide processing (GO:0006465)2.62722549
127intraciliary transport (GO:0042073)2.62442791
128regulation of meiosis I (GO:0060631)2.61301823
129vascular smooth muscle contraction (GO:0014829)2.56502036
130positive regulation of ligase activity (GO:0051351)2.53147007
131regulation of cilium movement (GO:0003352)2.52782480
132xenobiotic catabolic process (GO:0042178)2.52585004
133signal transduction involved in cell cycle checkpoint (GO:0072395)2.52558892
134protein K6-linked ubiquitination (GO:0085020)2.47722298
135cilium morphogenesis (GO:0060271)2.47651108
136regulation of sulfur metabolic process (GO:0042762)2.47344704
137organelle disassembly (GO:1903008)2.42995998
138DNA ligation (GO:0006266)2.42936156
139purine nucleobase biosynthetic process (GO:0009113)2.39480388
140DNA replication-independent nucleosome organization (GO:0034724)2.39370132
141DNA replication-independent nucleosome assembly (GO:0006336)2.39370132
142prenylation (GO:0097354)2.38873467
143protein prenylation (GO:0018342)2.38873467
144peptidyl-cysteine modification (GO:0018198)2.35763004
145establishment of viral latency (GO:0019043)2.35732379
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.34714464
147regulation of mitotic spindle checkpoint (GO:1903504)2.34714464
148regulation of ubiquitin-protein transferase activity (GO:0051438)2.33697170
1497-methylguanosine mRNA capping (GO:0006370)2.33470131
150epithelial cilium movement (GO:0003351)2.33098996
151centriole replication (GO:0007099)2.31575935
152isotype switching (GO:0045190)2.30266058
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.30266058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.21079462
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.18313962
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.83304894
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61694075
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.32280267
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.95907843
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83627739
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.56363737
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55842318
10VDR_22108803_ChIP-Seq_LS180_Human2.49259671
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48734572
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47571594
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44858482
14GBX2_23144817_ChIP-Seq_PC3_Human2.42411923
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.40686620
16TAF15_26573619_Chip-Seq_HEK293_Human2.39434421
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38508912
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17887425
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.16359298
20ELK1_19687146_ChIP-ChIP_HELA_Human2.12512386
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11557520
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.08161174
23FUS_26573619_Chip-Seq_HEK293_Human1.99773024
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96552090
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95497969
26ZNF274_21170338_ChIP-Seq_K562_Hela1.91481472
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90109508
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88850458
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79839481
30ER_23166858_ChIP-Seq_MCF-7_Human1.76764511
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76280713
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68331115
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68331115
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67162072
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65090738
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64607891
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.64163812
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61631658
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58573735
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57932080
41P300_19829295_ChIP-Seq_ESCs_Human1.57102108
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56704842
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.54285505
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.54251203
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49495906
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.47730922
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43166079
48VDR_23849224_ChIP-Seq_CD4+_Human1.42276252
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40043084
50DCP1A_22483619_ChIP-Seq_HELA_Human1.36994673
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36803400
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36642295
53IGF1R_20145208_ChIP-Seq_DFB_Human1.35418446
54AR_21909140_ChIP-Seq_LNCAP_Human1.34485609
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33128566
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32753623
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31710542
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.31475669
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30759719
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28897534
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28681634
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.27772066
63BCAT_22108803_ChIP-Seq_LS180_Human1.27195801
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26173268
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25409485
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.23633666
67EWS_26573619_Chip-Seq_HEK293_Human1.23514162
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23225275
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22964533
70P300_18555785_Chip-Seq_ESCs_Mouse1.19163940
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18038637
72NANOG_19829295_ChIP-Seq_ESCs_Human1.17987267
73SOX2_19829295_ChIP-Seq_ESCs_Human1.17987267
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16861986
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15963919
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.15145111
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14275032
78JUN_21703547_ChIP-Seq_K562_Human1.13845587
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13648716
80MYC_18940864_ChIP-ChIP_HL60_Human1.13409990
81CBP_20019798_ChIP-Seq_JUKART_Human1.12985754
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12985754
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.12297362
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11950882
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10743444
86AR_25329375_ChIP-Seq_VCAP_Human1.10627238
87TCF4_22108803_ChIP-Seq_LS180_Human1.09891451
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09083586
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07413694
90CDX2_22108803_ChIP-Seq_LS180_Human1.07290728
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05969974
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05896044
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.05754963
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05327614
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.04777525
96STAT3_23295773_ChIP-Seq_U87_Human1.03381685
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03363137
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03264650
99HTT_18923047_ChIP-ChIP_STHdh_Human1.03146221
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.02799054
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02769184
102SMAD4_21799915_ChIP-Seq_A2780_Human1.02123209
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.01785342
104EOMES_21245162_ChIP-Seq_HESCs_Human0.99990503
105OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99593141
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98791681
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.98494134
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96845124
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.96152005
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95955109
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95794409
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94532697
113SALL4_22934838_ChIP-ChIP_CD34+_Human0.92180399
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91160507
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.91121567
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.91110902
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90932222
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90901936
119P53_22387025_ChIP-Seq_ESCs_Mouse0.90363777
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.90350897
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.89521526
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89396130
123CBX2_27304074_Chip-Seq_ESCs_Mouse0.88392462
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.87602364
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87569244
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.87326559
127REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87139716
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86878866
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.86513863
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.86337819
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85621014
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.85462644
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.84705934
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83440411
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82990646
136FOXP3_21729870_ChIP-Seq_TREG_Human0.82987370
137EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82898382
138EZH2_27304074_Chip-Seq_ESCs_Mouse0.82341787
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81501976
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.81034191
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79772979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.23381874
2MP0003880_abnormal_central_pattern4.12772626
3MP0008877_abnormal_DNA_methylation2.98618558
4MP0006036_abnormal_mitochondrial_physio2.76711929
5MP0004036_abnormal_muscle_relaxation2.73370093
6MP0000749_muscle_degeneration2.61320577
7MP0001529_abnormal_vocalization2.60906739
8MP0001905_abnormal_dopamine_level2.53482051
9MP0008058_abnormal_DNA_repair2.50345691
10MP0003011_delayed_dark_adaptation2.43329343
11MP0002938_white_spotting2.40226221
12MP0004215_abnormal_myocardial_fiber2.33458215
13MP0003941_abnormal_skin_development2.30696165
14MP0004084_abnormal_cardiac_muscle2.29537386
15MP0003890_abnormal_embryonic-extraembry2.23320320
16MP0005171_absent_coat_pigmentation2.19521763
17MP0002736_abnormal_nociception_after2.17568270
18MP0000920_abnormal_myelination2.14280015
19MP0003806_abnormal_nucleotide_metabolis2.12348153
20MP0004145_abnormal_muscle_electrophysio2.12030255
21MP0006035_abnormal_mitochondrial_morpho2.05260330
22MP0006072_abnormal_retinal_apoptosis2.04517990
23MP0005330_cardiomyopathy2.04340499
24MP0003646_muscle_fatigue2.03583092
25MP0001986_abnormal_taste_sensitivity2.01141803
26MP0008438_abnormal_cutaneous_collagen1.97355517
27MP0008057_abnormal_DNA_replication1.97081100
28MP0001984_abnormal_olfaction1.96805155
29MP0003718_maternal_effect1.96402815
30MP0002102_abnormal_ear_morphology1.94032081
31MP0003186_abnormal_redox_activity1.93103238
32MP0001968_abnormal_touch/_nociception1.84878072
33MP0000013_abnormal_adipose_tissue1.84714332
34MP0000751_myopathy1.80548210
35MP0002272_abnormal_nervous_system1.78403687
36MP0002735_abnormal_chemical_nociception1.74328355
37MP0000372_irregular_coat_pigmentation1.73982750
38MP0002090_abnormal_vision1.73803035
39MP0003950_abnormal_plasma_membrane1.71141657
40MP0005253_abnormal_eye_physiology1.69836359
41MP0001440_abnormal_grooming_behavior1.69709031
42MP0001542_abnormal_bone_strength1.65883054
43MP0010094_abnormal_chromosome_stability1.64515088
44MP0002064_seizures1.63246573
45MP0002876_abnormal_thyroid_physiology1.62431666
46MP0000569_abnormal_digit_pigmentation1.62272158
47MP0005075_abnormal_melanosome_morpholog1.60923466
48MP0006054_spinal_hemorrhage1.58589975
49MP0003329_amyloid_beta_deposits1.58522539
50MP0004270_analgesia1.58431516
51MP0005551_abnormal_eye_electrophysiolog1.57892383
52MP0002972_abnormal_cardiac_muscle1.56855926
53MP0004147_increased_porphyrin_level1.56056465
54MP0006276_abnormal_autonomic_nervous1.55248271
55MP0009745_abnormal_behavioral_response1.55113399
56MP0005620_abnormal_muscle_contractility1.54403352
57MP0004957_abnormal_blastocyst_morpholog1.54048656
58MP0002254_reproductive_system_inflammat1.53025948
59MP0003136_yellow_coat_color1.52236605
60MP0002734_abnormal_mechanical_nocicepti1.52014246
61MP0009046_muscle_twitch1.51160877
62MP0004484_altered_response_of1.48383421
63MP0004142_abnormal_muscle_tone1.44169571
64MP0003690_abnormal_glial_cell1.42627359
65MP0005084_abnormal_gallbladder_morpholo1.42554945
66MP0001501_abnormal_sleep_pattern1.38888980
67MP0010234_abnormal_vibrissa_follicle1.36348462
68MP0002751_abnormal_autonomic_nervous1.35064982
69MP0002332_abnormal_exercise_endurance1.34010706
70MP0003221_abnormal_cardiomyocyte_apopto1.33379293
71MP0008875_abnormal_xenobiotic_pharmacok1.31366980
72MP0002106_abnormal_muscle_physiology1.31011115
73MP0003195_calcinosis1.29143769
74MP0000747_muscle_weakness1.28996612
75MP0009379_abnormal_foot_pigmentation1.27633708
76MP0002148_abnormal_hypersensitivity_rea1.27132185
77MP0010386_abnormal_urinary_bladder1.26533417
78MP0001970_abnormal_pain_threshold1.25882383
79MP0002295_abnormal_pulmonary_circulatio1.25322268
80MP0008775_abnormal_heart_ventricle1.24644058
81MP0003635_abnormal_synaptic_transmissio1.24379094
82MP0005369_muscle_phenotype1.22490751
83MP0008789_abnormal_olfactory_epithelium1.21182425
84MP0008007_abnormal_cellular_replicative1.20726203
85MP0003937_abnormal_limbs/digits/tail_de1.20371944
86MP0004859_abnormal_synaptic_plasticity1.20311100
87MP0000647_abnormal_sebaceous_gland1.19965400
88MP0010678_abnormal_skin_adnexa1.19229635
89MP0008932_abnormal_embryonic_tissue1.18414263
90MP0009785_altered_susceptibility_to1.16277548
91MP0001293_anophthalmia1.15847634
92MP0002067_abnormal_sensory_capabilities1.15448780
93MP0000343_altered_response_to1.15388681
94MP0003121_genomic_imprinting1.15223374
95MP0001727_abnormal_embryo_implantation1.14905987
96MP0005503_abnormal_tendon_morphology1.13967994
97MP0005386_behavior/neurological_phenoty1.10070029
98MP0004924_abnormal_behavior1.10070029
99MP0001544_abnormal_cardiovascular_syste1.09621139
100MP0005385_cardiovascular_system_phenoty1.09621139
101MP0002909_abnormal_adrenal_gland1.08224417
102MP0002733_abnormal_thermal_nociception1.07961361
103MP0005085_abnormal_gallbladder_physiolo1.07336304
104MP0000516_abnormal_urinary_system1.07250932
105MP0005367_renal/urinary_system_phenotyp1.07250932
106MP0005623_abnormal_meninges_morphology1.07087216
107MP0005174_abnormal_tail_pigmentation1.06960013
108MP0003122_maternal_imprinting1.05179463
109MP0003137_abnormal_impulse_conducting1.04876316
110MP0004019_abnormal_vitamin_homeostasis1.03658814
111MP0001929_abnormal_gametogenesis1.03138849
112MP0002572_abnormal_emotion/affect_behav1.02537876
113MP0009780_abnormal_chondrocyte_physiolo1.02517514
114MP0001324_abnormal_eye_pigmentation1.02118185
115MP0006138_congestive_heart_failure1.02088356
116MP0002063_abnormal_learning/memory/cond1.01920060
117MP0002282_abnormal_trachea_morphology1.01424898
118MP0005535_abnormal_body_temperature1.01354677
119MP0005187_abnormal_penis_morphology1.01257024
120MP0000631_abnormal_neuroendocrine_gland1.00997213
121MP0002233_abnormal_nose_morphology0.99555792
122MP0002822_catalepsy0.99300739
123MP0004087_abnormal_muscle_fiber0.98551613
124MP0008872_abnormal_physiological_respon0.97953531
125MP0005332_abnormal_amino_acid0.97168853
126MP0002210_abnormal_sex_determination0.97078801
127MP0001485_abnormal_pinna_reflex0.96689433
128MP0003634_abnormal_glial_cell0.95280729
129MP0004043_abnormal_pH_regulation0.94562950
130MP0005165_increased_susceptibility_to0.94030908
131MP0003119_abnormal_digestive_system0.92901431
132MP0002095_abnormal_skin_pigmentation0.92726612
133MP0002638_abnormal_pupillary_reflex0.92517473
134MP0000653_abnormal_sex_gland0.92089756
135MP0001764_abnormal_homeostasis0.91944358
136MP0004130_abnormal_muscle_cell0.91288035
137MP0000750_abnormal_muscle_regeneration0.91060263
138MP0003786_premature_aging0.90399106
139MP0000383_abnormal_hair_follicle0.90057900
140MP0003633_abnormal_nervous_system0.89466356
141MP0000604_amyloidosis0.88833483
142MP0002229_neurodegeneration0.88477537
143MP0005164_abnormal_response_to0.88030643
144MP0000759_abnormal_skeletal_muscle0.87677245
145MP0005379_endocrine/exocrine_gland_phen0.87332273
146MP0000230_abnormal_systemic_arterial0.87160532
147MP0000427_abnormal_hair_cycle0.85602194
148MP0000358_abnormal_cell_content/0.85433352
149MP0004133_heterotaxia0.85407833
150MP0001756_abnormal_urination0.84908758
151MP0001188_hyperpigmentation0.84571688
152MP0009697_abnormal_copulation0.84076442
153MP0001486_abnormal_startle_reflex0.84040883
154MP0005646_abnormal_pituitary_gland0.82549910
155MP0004742_abnormal_vestibular_system0.82433614
156MP0005408_hypopigmentation0.82171076
157MP0002160_abnormal_reproductive_system0.81917772
158MP0005391_vision/eye_phenotype0.81903045
159MP0005645_abnormal_hypothalamus_physiol0.81384073
160MP0005365_abnormal_bile_salt0.81270821
161MP0003077_abnormal_cell_cycle0.81166090
162MP0001145_abnormal_male_reproductive0.80920795
163MP0006292_abnormal_olfactory_placode0.80189049
164MP0001661_extended_life_span0.79912380
165MP0001177_atelectasis0.79822341
166MP0003631_nervous_system_phenotype0.79385432
167MP0005395_other_phenotype0.79059705
168MP0004134_abnormal_chest_morphology0.78785443
169MP0003787_abnormal_imprinting0.76518714
170MP0000538_abnormal_urinary_bladder0.76025837
171MP0001299_abnormal_eye_distance/0.75965375
172MP0003693_abnormal_embryo_hatching0.74972724

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.77027721
2Abnormal mitochondria in muscle tissue (HP:0008316)6.14482603
3Mitochondrial inheritance (HP:0001427)5.85500531
4Progressive macrocephaly (HP:0004481)5.78543062
5Acute encephalopathy (HP:0006846)5.64177903
6Increased CSF lactate (HP:0002490)5.15762226
7Abnormality of glycolysis (HP:0004366)5.15639351
8Increased serum pyruvate (HP:0003542)5.15639351
9Hepatocellular necrosis (HP:0001404)5.08697622
10Hepatic necrosis (HP:0002605)4.74167088
11Increased hepatocellular lipid droplets (HP:0006565)4.68262094
12Lipid accumulation in hepatocytes (HP:0006561)4.38604949
13Exercise intolerance (HP:0003546)3.97818620
14Renal Fanconi syndrome (HP:0001994)3.93594607
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.93313848
16Cerebral edema (HP:0002181)3.92951363
17Respiratory failure (HP:0002878)3.68259053
18Lactic acidosis (HP:0003128)3.56001860
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.53108453
20Increased intramyocellular lipid droplets (HP:0012240)3.50267525
21Leukodystrophy (HP:0002415)3.48027269
22Optic disc pallor (HP:0000543)3.44513481
23Neuroendocrine neoplasm (HP:0100634)3.40500281
24Parakeratosis (HP:0001036)3.31303821
25Increased serum lactate (HP:0002151)3.23378591
26Increased muscle lipid content (HP:0009058)3.23246445
273-Methylglutaconic aciduria (HP:0003535)3.20293634
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.19568608
29Pheochromocytoma (HP:0002666)3.16438613
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95861231
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95861231
32Exertional dyspnea (HP:0002875)2.92972974
33Muscle hypertrophy of the lower extremities (HP:0008968)2.87807210
34Intestinal atresia (HP:0011100)2.86251308
35True hermaphroditism (HP:0010459)2.79589433
36X-linked dominant inheritance (HP:0001423)2.74183340
37Pancreatic cysts (HP:0001737)2.69163324
38Calf muscle hypertrophy (HP:0008981)2.68835226
39Pancreatic fibrosis (HP:0100732)2.68320926
40Exercise-induced muscle cramps (HP:0003710)2.68168674
41Respiratory difficulties (HP:0002880)2.66246375
42Abnormality of the labia minora (HP:0012880)2.58006054
43Gonadotropin excess (HP:0000837)2.53958152
44Abnormality of renal resorption (HP:0011038)2.53028214
45Oligodactyly (hands) (HP:0001180)2.51713324
46Methylmalonic acidemia (HP:0002912)2.45498167
47Hypothermia (HP:0002045)2.42736337
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.41452434
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41452434
50Sensory axonal neuropathy (HP:0003390)2.40379686
51Patchy hypopigmentation of hair (HP:0011365)2.38274273
52Muscle fiber splitting (HP:0003555)2.37254953
53Abnormality of midbrain morphology (HP:0002418)2.36329867
54Molar tooth sign on MRI (HP:0002419)2.36329867
55Volvulus (HP:0002580)2.35802446
56Hypoglycemic coma (HP:0001325)2.33401007
57Congenital, generalized hypertrichosis (HP:0004540)2.33045847
58Large for gestational age (HP:0001520)2.32872964
59Cerebral hemorrhage (HP:0001342)2.32699488
60Hyperinsulinemic hypoglycemia (HP:0000825)2.31754692
61CNS demyelination (HP:0007305)2.30986005
62Genital tract atresia (HP:0001827)2.30724272
63Nephronophthisis (HP:0000090)2.28870455
64Palpitations (HP:0001962)2.25896720
65Type I transferrin isoform profile (HP:0003642)2.24803784
66Methylmalonic aciduria (HP:0012120)2.21329405
67Focal motor seizures (HP:0011153)2.20738856
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20360163
69Autoamputation (HP:0001218)2.19475707
70Medial flaring of the eyebrow (HP:0010747)2.17904846
71Conjunctival hamartoma (HP:0100780)2.16900642
72Vaginal atresia (HP:0000148)2.16854123
73Abnormality of alanine metabolism (HP:0010916)2.14226391
74Hyperalaninemia (HP:0003348)2.14226391
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14226391
76Abnormality of the anterior horn cell (HP:0006802)2.12157859
77Degeneration of anterior horn cells (HP:0002398)2.12157859
78Abnormality of methionine metabolism (HP:0010901)2.10641863
79Median cleft lip (HP:0000161)2.09683491
80Myotonia (HP:0002486)2.09337403
81Emotional lability (HP:0000712)2.08613383
82Abnormality of urine glucose concentration (HP:0011016)2.08469612
83Glycosuria (HP:0003076)2.08469612
84Nephrogenic diabetes insipidus (HP:0009806)2.07922866
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.07033703
86Congenital ichthyosiform erythroderma (HP:0007431)2.06752705
87Abnormality of the fovea (HP:0000493)2.06601064
88Hyperglycinemia (HP:0002154)2.05389751
89Lethargy (HP:0001254)2.04906386
90Hypoglycemic seizures (HP:0002173)2.03522876
91Short tibia (HP:0005736)2.03240940
92Hypoplasia of the fovea (HP:0007750)2.02174904
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.02174904
94Abnormality of cells of the erythroid lineage (HP:0012130)2.00234415
95Abnormality of the renal medulla (HP:0100957)1.98285011
96Nemaline bodies (HP:0003798)1.96463351
97Abnormality of serum amino acid levels (HP:0003112)1.96263136
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95852316
99Pancreatic islet-cell hyperplasia (HP:0004510)1.95335573
100Muscle fiber inclusion bodies (HP:0100299)1.94758447
101Neurofibrillary tangles (HP:0002185)1.94017727
102Cerebral hypomyelination (HP:0006808)1.93627581
103Abnormality of the renal cortex (HP:0011035)1.93103939
104Sudden death (HP:0001699)1.92954613
105Atonic seizures (HP:0010819)1.90665274
106Abnormality of chromosome stability (HP:0003220)1.90446352
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90430178
108Hypoplastic left heart (HP:0004383)1.89931078
109Gliosis (HP:0002171)1.88677390
110Gastrointestinal atresia (HP:0002589)1.88095433
111Meckel diverticulum (HP:0002245)1.87241707
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.86743308
113Septo-optic dysplasia (HP:0100842)1.86304726
114Abnormal protein glycosylation (HP:0012346)1.86171011
115Abnormal glycosylation (HP:0012345)1.86171011
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86171011
117Abnormal protein N-linked glycosylation (HP:0012347)1.86171011
118Retinal dysplasia (HP:0007973)1.86133388
119Abnormality of the ileum (HP:0001549)1.84842137
120Progressive external ophthalmoplegia (HP:0000590)1.83797445
121Nausea (HP:0002018)1.80552593
122Exercise-induced myalgia (HP:0003738)1.79977426
123Aplasia/hypoplasia of the uterus (HP:0008684)1.78746893
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78551108
125Dicarboxylic aciduria (HP:0003215)1.78551108
126Respiratory insufficiency due to muscle weakness (HP:0002747)1.77393797
127Supernumerary spleens (HP:0009799)1.76027623
128Microvesicular hepatic steatosis (HP:0001414)1.75403783
129Delayed gross motor development (HP:0002194)1.74104995
130Abnormal lung lobation (HP:0002101)1.73939312
131Renal cortical cysts (HP:0000803)1.73003777
132Hypoplastic heart (HP:0001961)1.72277293
133Abnormal number of erythroid precursors (HP:0012131)1.71386051
134Rhabdomyolysis (HP:0003201)1.69493314
135Generalized aminoaciduria (HP:0002909)1.69351411
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.69301634
137Neoplasm of the adrenal gland (HP:0100631)1.68766310
138Muscle stiffness (HP:0003552)1.68527968
139Abnormality of the calf musculature (HP:0001430)1.68038694
140Myoglobinuria (HP:0002913)1.67960788
141Postnatal microcephaly (HP:0005484)1.67710204
142Bifid tongue (HP:0010297)1.66801172
143Rimmed vacuoles (HP:0003805)1.66748537
144Abnormal hair whorl (HP:0010721)1.66638512
145Posterior subcapsular cataract (HP:0007787)1.66493035
146Dialeptic seizures (HP:0011146)1.65116223
147Axonal loss (HP:0003447)1.63597351
148Renal tubular dysfunction (HP:0000124)1.62555389
149Anxiety (HP:0000739)1.60999106
150EMG: myopathic abnormalities (HP:0003458)1.60418527
151Myokymia (HP:0002411)1.59359084
152Congenital primary aphakia (HP:0007707)1.59210069
153Gait imbalance (HP:0002141)1.59178380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.70168576
2PBK3.23136371
3MYLK2.92117151
4STK392.83864513
5FRK2.67321664
6MST42.60612070
7RIPK42.49483745
8ARAF2.42430166
9PLK22.34429816
10WNK32.29381059
11NME12.28391882
12OBSCN2.26834881
13CASK2.18686776
14OXSR12.18028878
15STK162.17638037
16TRIM282.16720210
17GRK72.16397201
18LIMK12.14099625
19VRK21.98888453
20BMPR21.93941130
21BCR1.93801225
22ACVR1B1.92433241
23WEE11.87069598
24NME21.84952082
25MKNK21.73967753
26NUAK11.68067595
27PDK41.68015184
28PDK31.68015184
29GRK51.61629823
30NTRK31.58113304
31STK38L1.52369159
32GRK11.51678716
33TTK1.50547701
34VRK11.50474005
35TNIK1.50442362
36PDK21.48745218
37CDK191.43156898
38WNK41.41498556
39MUSK1.39541286
40PIK3CA1.36711722
41MAPKAPK51.36121019
42SRPK11.35875680
43FGFR21.33418548
44EIF2AK31.32770176
45CSNK1G11.29755069
46EIF2AK11.22809920
47NLK1.22130266
48MAP4K21.21699154
49IRAK41.21447323
50EPHA41.15382785
51BLK1.15254877
52TAF11.13042994
53BUB11.07423862
54CAMK2D1.05619713
55PINK11.03887698
56BMPR1B1.02013849
57MAP2K71.01938876
58PLK10.99202294
59STK30.98948862
60CSNK1G20.96717294
61CAMK2A0.94700642
62PLK40.93712144
63STK240.92193449
64NEK60.90346060
65PRKCE0.89282672
66FGR0.88168825
67CAMK2B0.87618503
68PTK2B0.87191911
69ROCK20.84941437
70MINK10.84498289
71FGFR10.82432067
72TRPM70.80455118
73NEK90.79647498
74PNCK0.78756573
75MAP3K130.78314574
76ILK0.78016279
77ADRBK20.77883189
78ABL20.77045091
79CCNB10.76366451
80CAMK2G0.75682333
81PIM20.72696900
82BCKDK0.72406323
83FER0.71852732
84BRAF0.71522470
85CDC70.71102630
86ADRBK10.68806746
87PLK30.66664546
88TGFBR10.66626855
89ERBB30.64561484
90MOS0.63998920
91INSRR0.63584255
92ERBB40.63093071
93PHKG20.62314151
94PHKG10.62314151
95PKN10.62172222
96CSNK1A1L0.60465251
97TESK10.59231356
98MAP3K90.59176708
99MAP3K140.58993181
100CSNK1G30.58314238
101CDK30.57042807
102MAP3K20.56285234
103PRKCQ0.55912768
104ZAK0.53584107
105CDK140.53505451
106PIK3CG0.53145760
107PAK30.52659638
108BRSK10.52642944
109EIF2AK20.51313211
110TXK0.50566356
111TSSK60.46310193
112PRKACA0.46284540
113PRKCG0.45947014
114MKNK10.45125154
115MAP3K40.44665990
116MAPK130.44550926
117MAP2K40.44107410
118AKT30.43723111
119PRKCI0.43496226
120ATM0.42584062
121PASK0.42454614
122MET0.41733393
123TTN0.41512420
124IRAK30.40930712
125DAPK30.40742148
126EPHB10.40099671
127DYRK30.38120414
128CSNK1A10.37386067
129PRKG10.37356106
130CSNK2A10.37355793
131CDK180.37339833
132PRKCD0.37306748
133WNK10.36794218
134BRSK20.36029185
135NTRK10.35925630
136AURKB0.35123523
137CSNK1E0.34713074
138CSNK2A20.33767903
139TIE10.33503521
140SIK30.31909455
141ATR0.31788792
142NEK10.31117068
143CDK150.31015627
144CDK50.30968090
145STK100.30591754
146MARK30.30444597
147LMTK20.29646147

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.99181871
2Parkinsons disease_Homo sapiens_hsa050124.97638057
3Proteasome_Homo sapiens_hsa030504.01958182
4Alzheimers disease_Homo sapiens_hsa050103.92980798
5Huntingtons disease_Homo sapiens_hsa050163.47991118
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.02548454
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88509844
8Collecting duct acid secretion_Homo sapiens_hsa049662.64804009
9Protein export_Homo sapiens_hsa030602.57193512
10Fatty acid elongation_Homo sapiens_hsa000622.55709226
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.55458088
12Cardiac muscle contraction_Homo sapiens_hsa042602.53529666
13RNA polymerase_Homo sapiens_hsa030202.06582517
14Ribosome_Homo sapiens_hsa030101.99580648
15Mismatch repair_Homo sapiens_hsa034301.85989034
16Non-homologous end-joining_Homo sapiens_hsa034501.76778953
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74599307
18Rheumatoid arthritis_Homo sapiens_hsa053231.73271525
19Vibrio cholerae infection_Homo sapiens_hsa051101.67368262
20Propanoate metabolism_Homo sapiens_hsa006401.66516670
21Homologous recombination_Homo sapiens_hsa034401.65712712
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64489121
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.63994096
24Steroid biosynthesis_Homo sapiens_hsa001001.45117504
25Nitrogen metabolism_Homo sapiens_hsa009101.40649721
26RNA degradation_Homo sapiens_hsa030181.40306439
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38272751
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34065666
29Pyruvate metabolism_Homo sapiens_hsa006201.31196093
30Fanconi anemia pathway_Homo sapiens_hsa034601.27513218
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.24698967
32Phagosome_Homo sapiens_hsa041451.22741197
33Folate biosynthesis_Homo sapiens_hsa007901.21085738
34Selenocompound metabolism_Homo sapiens_hsa004501.20086490
35Nucleotide excision repair_Homo sapiens_hsa034201.19652155
36RNA transport_Homo sapiens_hsa030131.18368296
37Caffeine metabolism_Homo sapiens_hsa002321.16700053
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16223882
39beta-Alanine metabolism_Homo sapiens_hsa004101.13031506
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12648414
41Tryptophan metabolism_Homo sapiens_hsa003801.11245892
42One carbon pool by folate_Homo sapiens_hsa006701.10014131
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07666848
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.04773509
45Graft-versus-host disease_Homo sapiens_hsa053321.02148640
46Sulfur metabolism_Homo sapiens_hsa009201.01060514
47Synaptic vesicle cycle_Homo sapiens_hsa047210.99302710
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98473359
49Ether lipid metabolism_Homo sapiens_hsa005650.98053952
50DNA replication_Homo sapiens_hsa030300.97166455
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96633809
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93200158
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92850387
54Carbon metabolism_Homo sapiens_hsa012000.91409777
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91259872
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88025039
57Nicotine addiction_Homo sapiens_hsa050330.86325977
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81671145
59Chemical carcinogenesis_Homo sapiens_hsa052040.78022084
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77636863
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77188277
62Serotonergic synapse_Homo sapiens_hsa047260.76770237
63Metabolic pathways_Homo sapiens_hsa011000.75878458
64Oocyte meiosis_Homo sapiens_hsa041140.75717996
65Pyrimidine metabolism_Homo sapiens_hsa002400.74920417
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73745493
67Base excision repair_Homo sapiens_hsa034100.73013818
68Retinol metabolism_Homo sapiens_hsa008300.72563602
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71087722
70Circadian rhythm_Homo sapiens_hsa047100.69214923
71Olfactory transduction_Homo sapiens_hsa047400.67969391
72Spliceosome_Homo sapiens_hsa030400.67890148
73Glutathione metabolism_Homo sapiens_hsa004800.65686701
74Fatty acid metabolism_Homo sapiens_hsa012120.64001084
75Arachidonic acid metabolism_Homo sapiens_hsa005900.63950365
76Purine metabolism_Homo sapiens_hsa002300.63370926
77Sphingolipid metabolism_Homo sapiens_hsa006000.61998664
78Mineral absorption_Homo sapiens_hsa049780.60959349
79Peroxisome_Homo sapiens_hsa041460.58944214
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58581446
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57957385
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57623037
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55600826
84GABAergic synapse_Homo sapiens_hsa047270.55556396
85African trypanosomiasis_Homo sapiens_hsa051430.54759810
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52185323
87Hedgehog signaling pathway_Homo sapiens_hsa043400.51511024
88Vitamin B6 metabolism_Homo sapiens_hsa007500.51131588
89Cell cycle_Homo sapiens_hsa041100.50959261
90Circadian entrainment_Homo sapiens_hsa047130.50787139
91Regulation of autophagy_Homo sapiens_hsa041400.50439995
92TGF-beta signaling pathway_Homo sapiens_hsa043500.50042883
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49121247
94Type I diabetes mellitus_Homo sapiens_hsa049400.48899733
95Morphine addiction_Homo sapiens_hsa050320.48667875
96Basal cell carcinoma_Homo sapiens_hsa052170.48056592
97Allograft rejection_Homo sapiens_hsa053300.46663129
98Butanoate metabolism_Homo sapiens_hsa006500.46481937
99Calcium signaling pathway_Homo sapiens_hsa040200.45711998
100Taste transduction_Homo sapiens_hsa047420.44893057
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.42745321
102N-Glycan biosynthesis_Homo sapiens_hsa005100.42230975
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41738522
104Dopaminergic synapse_Homo sapiens_hsa047280.40965660
105Autoimmune thyroid disease_Homo sapiens_hsa053200.40609134
106Glutamatergic synapse_Homo sapiens_hsa047240.40477173
107Long-term potentiation_Homo sapiens_hsa047200.40024685
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39055788
109Renin secretion_Homo sapiens_hsa049240.38953547
110Malaria_Homo sapiens_hsa051440.38486557
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38464135
112Tight junction_Homo sapiens_hsa045300.38355700
113Salmonella infection_Homo sapiens_hsa051320.37207469
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37098993
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37041239
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36622380
117Hippo signaling pathway_Homo sapiens_hsa043900.35424338
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35327587
119Basal transcription factors_Homo sapiens_hsa030220.35318716
120Arginine and proline metabolism_Homo sapiens_hsa003300.35128815
121Pertussis_Homo sapiens_hsa051330.33689464
122Linoleic acid metabolism_Homo sapiens_hsa005910.32934820
123Fatty acid degradation_Homo sapiens_hsa000710.32902095
124Asthma_Homo sapiens_hsa053100.32575119
125Histidine metabolism_Homo sapiens_hsa003400.32409984
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31982356
127Starch and sucrose metabolism_Homo sapiens_hsa005000.31848444
128Phototransduction_Homo sapiens_hsa047440.30937885
129Long-term depression_Homo sapiens_hsa047300.30756557
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29567906
131Dilated cardiomyopathy_Homo sapiens_hsa054140.29215702
132p53 signaling pathway_Homo sapiens_hsa041150.28932093
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.28607017
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28318808
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28161776
136Legionellosis_Homo sapiens_hsa051340.27077181
137Tyrosine metabolism_Homo sapiens_hsa003500.26871466
138Phenylalanine metabolism_Homo sapiens_hsa003600.26037279
139Lysosome_Homo sapiens_hsa041420.24970751
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23756237
141Amphetamine addiction_Homo sapiens_hsa050310.23273137
142Tuberculosis_Homo sapiens_hsa051520.23168348
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21527837
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19363574
145Salivary secretion_Homo sapiens_hsa049700.19127840
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18492484
147Fructose and mannose metabolism_Homo sapiens_hsa000510.17914080
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17327873
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15460785

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