ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	5.76841463
2	translational termination (GO:0006415)	5.58970560
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.44910254
4	ATP synthesis coupled proton transport (GO:0015986)	5.25094286
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.25094286
6	ribosomal small subunit biogenesis (GO:0042274)	5.09612321
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.65349707
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.64248815
9	NADH dehydrogenase complex assembly (GO:0010257)	4.64248815
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.64248815
11	cotranslational protein targeting to membrane (GO:0006613)	4.61592709
12	translational elongation (GO:0006414)	4.58557019
13	protein targeting to ER (GO:0045047)	4.52487235
14	maturation of SSU-rRNA (GO:0030490)	4.44713608
15	chaperone-mediated protein transport (GO:0072321)	4.41301795
16	ribosomal small subunit assembly (GO:0000028)	4.40211040
17	behavioral response to nicotine (GO:0035095)	4.35676317
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.34139206
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.28623483
20	cellular protein complex disassembly (GO:0043624)	4.27759593
21	protein complex biogenesis (GO:0070271)	4.25091065
22	protein localization to endoplasmic reticulum (GO:0070972)	4.17202420
23	mitochondrial respiratory chain complex assembly (GO:0033108)	4.14958565
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.05572732
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.02362156
26	viral life cycle (GO:0019058)	4.00765409
27	respiratory electron transport chain (GO:0022904)	3.95646866
28	electron transport chain (GO:0022900)	3.93341939
29	translational initiation (GO:0006413)	3.86306809
30	protein-cofactor linkage (GO:0018065)	3.63878896
31	protein complex disassembly (GO:0043241)	3.63295670
32	DNA replication checkpoint (GO:0000076)	3.57399072
33	DNA deamination (GO:0045006)	3.55784368
34	chromatin remodeling at centromere (GO:0031055)	3.53960818
35	macromolecular complex disassembly (GO:0032984)	3.42780659
36	pseudouridine synthesis (GO:0001522)	3.39718390
37	CENP-A containing nucleosome assembly (GO:0034080)	3.26641200
38	translation (GO:0006412)	3.22587092
39	otic vesicle formation (GO:0030916)	3.19400700
40	water-soluble vitamin biosynthetic process (GO:0042364)	3.18812570
41	termination of RNA polymerase III transcription (GO:0006386)	3.17752051
42	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.17752051
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.08160747
44	protein K6-linked ubiquitination (GO:0085020)	3.07923158
45	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.06868256
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02222504
47	ribosomal large subunit biogenesis (GO:0042273)	3.01819376
48	ATP biosynthetic process (GO:0006754)	2.99267428
49	protein neddylation (GO:0045116)	2.96680479
50	mRNA catabolic process (GO:0006402)	2.93632762
51	respiratory chain complex IV assembly (GO:0008535)	2.93582619
52	cellular component biogenesis (GO:0044085)	2.93557026
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.91731753
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.90294833
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.88430088
56	proteasome assembly (GO:0043248)	2.86692291
57	protein targeting to membrane (GO:0006612)	2.85218679
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83522354
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83522354
60	negative regulation of telomere maintenance (GO:0032205)	2.81407874
61	histone exchange (GO:0043486)	2.78210344
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.77420111
63	ribonucleoprotein complex biogenesis (GO:0022613)	2.76381888
64	hydrogen ion transmembrane transport (GO:1902600)	2.76179584
65	rRNA modification (GO:0000154)	2.75034111
66	rRNA processing (GO:0006364)	2.74318984
67	rRNA metabolic process (GO:0016072)	2.74242797
68	sulfation (GO:0051923)	2.73058250
69	DNA replication-dependent nucleosome organization (GO:0034723)	2.72210828
70	DNA replication-dependent nucleosome assembly (GO:0006335)	2.72210828
71	replication fork processing (GO:0031297)	2.71911553
72	reciprocal DNA recombination (GO:0035825)	2.71867490
73	reciprocal meiotic recombination (GO:0007131)	2.71867490
74	protein polyglutamylation (GO:0018095)	2.71586108
75	tRNA processing (GO:0008033)	2.71177414
76	neurofilament cytoskeleton organization (GO:0060052)	2.69531048
77	intracellular protein transmembrane import (GO:0044743)	2.69349143
78	GTP biosynthetic process (GO:0006183)	2.67868782
79	epithelial cilium movement (GO:0003351)	2.67415393
80	cytochrome complex assembly (GO:0017004)	2.66942826
81	RNA catabolic process (GO:0006401)	2.66756995
82	somite development (GO:0061053)	2.65988254
83	maturation of 5.8S rRNA (GO:0000460)	2.64618257
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.64591967
85	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.64100305
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.64100305
87	recombinational repair (GO:0000725)	2.61088919
88	spinal cord motor neuron differentiation (GO:0021522)	2.59304877
89	DNA damage response, detection of DNA damage (GO:0042769)	2.58869807
90	double-strand break repair via homologous recombination (GO:0000724)	2.58678331
91	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.58428430
92	spliceosomal complex assembly (GO:0000245)	2.58348335
93	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54778336
94	spliceosomal snRNP assembly (GO:0000387)	2.53406629
95	peptidyl-histidine modification (GO:0018202)	2.53092744
96	platelet dense granule organization (GO:0060155)	2.51894636
97	proton transport (GO:0015992)	2.51437232
98	inner mitochondrial membrane organization (GO:0007007)	2.50594015
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.48500174
100	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.46089134

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42949761
2	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22969061
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.22074063
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.18735532
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.18340281
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.18135239
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.10015881
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.07669042
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.07635313
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.96912666
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.96606305
12	VDR_22108803_ChIP-Seq_LS180_Human	2.61341698
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40625745
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.28746397
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25052641
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.21850893
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.21395772
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.18661161
19	EWS_26573619_Chip-Seq_HEK293_Human	2.15132907
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.04666931
21	FUS_26573619_Chip-Seq_HEK293_Human	2.00893202
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.97548352
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.95529877
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.92737398
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.86831405
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84425722
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.83060040
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81627468
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.70989406
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.70965764
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.62391732
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59950204
33	XRN2_22483619_ChIP-Seq_HELA_Human	1.59130999
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.58328043
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54649932
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51225782
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49666345
38	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.49363698
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49177450
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48575199
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47852518
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.46451755
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.44105474
44	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.43794746
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43527867
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43412429
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38671706
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38433396
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37603868
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34424889
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.32185606
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.30108308
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.29835396
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29131225
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25897987
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.25287780
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22338038
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21952853
59	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.20677205
60	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17079094
61	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.16710367
62	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.16457517
63	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.14658465
64	P300_19829295_ChIP-Seq_ESCs_Human	1.12310289
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12029321
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10164741
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07740069
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.04677039
69	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02259080
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00634578
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00052752
72	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.99831238
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98977710
74	DCP1A_22483619_ChIP-Seq_HELA_Human	0.98430273
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97634729
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97634729
77	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97385337
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97254733
79	ERA_21632823_ChIP-Seq_H3396_Human	0.92562550
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92028823
81	NCOR_22424771_ChIP-Seq_293T_Human	0.92014250
82	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91583724
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.91496097
84	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90784617
85	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90247385
86	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89446486
87	REST_21632747_ChIP-Seq_MESCs_Mouse	0.89036656
88	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.88301040
89	AR_21572438_ChIP-Seq_LNCaP_Human	0.87332267
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87287277
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87287277
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85628736
93	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.85573762
94	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.85137454
95	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.84524693
96	AR_20517297_ChIP-Seq_VCAP_Human	0.83736153
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.82687950
98	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.82451445
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.81506273
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79847377

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.26078243
2	MP0009379_abnormal_foot_pigmentation	3.83265578
3	MP0006292_abnormal_olfactory_placode	2.96992063
4	MP0002938_white_spotting	2.27419886
5	MP0002736_abnormal_nociception_after	2.06132973
6	MP0002638_abnormal_pupillary_reflex	2.00885549
7	MP0002160_abnormal_reproductive_system	1.97313941
8	MP0008058_abnormal_DNA_repair	1.92159560
9	MP0005551_abnormal_eye_electrophysiolog	1.80735456
10	MP0000049_abnormal_middle_ear	1.79579906
11	MP0009046_muscle_twitch	1.76579121
12	MP0005646_abnormal_pituitary_gland	1.76070835
13	MP0001968_abnormal_touch/_nociception	1.74348362
14	MP0002653_abnormal_ependyma_morphology	1.73566056
15	MP0003880_abnormal_central_pattern	1.71812557
16	MP0008995_early_reproductive_senescence	1.69690815
17	MP0010094_abnormal_chromosome_stability	1.68348406
18	MP0003693_abnormal_embryo_hatching	1.67735203
19	MP0000631_abnormal_neuroendocrine_gland	1.67636559
20	MP0003011_delayed_dark_adaptation	1.63783550
21	MP0001485_abnormal_pinna_reflex	1.63751778
22	MP0004147_increased_porphyrin_level	1.61728677
23	MP0002735_abnormal_chemical_nociception	1.58953748
24	MP0002163_abnormal_gland_morphology	1.57116978
25	MP0010030_abnormal_orbit_morphology	1.57047887
26	MP0008877_abnormal_DNA_methylation	1.55520914
27	MP0003195_calcinosis	1.54801164
28	MP0004142_abnormal_muscle_tone	1.54115631
29	MP0002277_abnormal_respiratory_mucosa	1.53507295
30	MP0000569_abnormal_digit_pigmentation	1.51400487
31	MP0001529_abnormal_vocalization	1.50903046
32	MP0004742_abnormal_vestibular_system	1.47516002
33	MP0003718_maternal_effect	1.45498522
34	MP0002234_abnormal_pharynx_morphology	1.45262954
35	MP0001293_anophthalmia	1.44692579
36	MP0002102_abnormal_ear_morphology	1.44529437
37	MP0005389_reproductive_system_phenotype	1.43982581
38	MP0009745_abnormal_behavioral_response	1.42760904
39	MP0005174_abnormal_tail_pigmentation	1.41209926
40	MP0004885_abnormal_endolymph	1.39677996
41	MP0008875_abnormal_xenobiotic_pharmacok	1.37547063
42	MP0006072_abnormal_retinal_apoptosis	1.36342114
43	MP0004133_heterotaxia	1.31591817
44	MP0002249_abnormal_larynx_morphology	1.29636593
45	MP0003890_abnormal_embryonic-extraembry	1.28843624
46	MP0005171_absent_coat_pigmentation	1.25098875
47	MP0000372_irregular_coat_pigmentation	1.24844883
48	MP0008872_abnormal_physiological_respon	1.23209896
49	MP0003937_abnormal_limbs/digits/tail_de	1.21430262
50	MP0002751_abnormal_autonomic_nervous	1.19602010
51	MP0005253_abnormal_eye_physiology	1.15608460
52	MP0002095_abnormal_skin_pigmentation	1.15353195
53	MP0002272_abnormal_nervous_system	1.14063971
54	MP0005645_abnormal_hypothalamus_physiol	1.13798365
55	MP0001486_abnormal_startle_reflex	1.12731747
56	MP0001919_abnormal_reproductive_system	1.11886809
57	MP0003283_abnormal_digestive_organ	1.10697229
58	MP0002837_dystrophic_cardiac_calcinosis	1.09699474
59	MP0000026_abnormal_inner_ear	1.08690831
60	MP0003878_abnormal_ear_physiology	1.07036381
61	MP0005377_hearing/vestibular/ear_phenot	1.07036381
62	MP0005195_abnormal_posterior_eye	1.05667564
63	MP0004145_abnormal_muscle_electrophysio	1.04401479
64	MP0001286_abnormal_eye_development	1.04351889
65	MP0002210_abnormal_sex_determination	1.04031029
66	MP0000778_abnormal_nervous_system	1.03861852
67	MP0001986_abnormal_taste_sensitivity	1.03644194
68	MP0003786_premature_aging	1.02583159
69	MP0006276_abnormal_autonomic_nervous	1.02158676
70	MP0002752_abnormal_somatic_nervous	0.99869338
71	MP0002064_seizures	0.99681406
72	MP0005187_abnormal_penis_morphology	0.99177556
73	MP0005423_abnormal_somatic_nervous	0.98903527
74	MP0003938_abnormal_ear_development	0.97469551
75	MP0008057_abnormal_DNA_replication	0.97178906
76	MP0002557_abnormal_social/conspecific_i	0.96422187
77	MP0002067_abnormal_sensory_capabilities	0.93811172
78	MP0001188_hyperpigmentation	0.93222295
79	MP0002184_abnormal_innervation	0.92612153
80	MP0005379_endocrine/exocrine_gland_phen	0.90035216
81	MP0001324_abnormal_eye_pigmentation	0.89892892
82	MP0008932_abnormal_embryonic_tissue	0.89697647
83	MP0002928_abnormal_bile_duct	0.89598947
84	MP0003121_genomic_imprinting	0.89339598
85	MP0000955_abnormal_spinal_cord	0.88896263
86	MP0002572_abnormal_emotion/affect_behav	0.88862863
87	MP0005084_abnormal_gallbladder_morpholo	0.88403037
88	MP0001905_abnormal_dopamine_level	0.87209470
89	MP0001970_abnormal_pain_threshold	0.86957814
90	MP0003119_abnormal_digestive_system	0.85494969
91	MP0003077_abnormal_cell_cycle	0.85494159
92	MP0003186_abnormal_redox_activity	0.84070341
93	MP0004043_abnormal_pH_regulation	0.83517951
94	MP0002876_abnormal_thyroid_physiology	0.83201295
95	MP0000647_abnormal_sebaceous_gland	0.83056475
96	MP0001929_abnormal_gametogenesis	0.82806062
97	MP0003755_abnormal_palate_morphology	0.82643104
98	MP0005083_abnormal_biliary_tract	0.82390813
99	MP0005391_vision/eye_phenotype	0.81591632
100	MP0003111_abnormal_nucleus_morphology	0.81530416

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.06861165
2	True hermaphroditism (HP:0010459)	3.82816210
3	Abnormal number of erythroid precursors (HP:0012131)	3.81048951
4	Pancreatic fibrosis (HP:0100732)	3.77449572
5	Reticulocytopenia (HP:0001896)	3.72782826
6	Abnormality of midbrain morphology (HP:0002418)	3.66151125
7	Molar tooth sign on MRI (HP:0002419)	3.66151125
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.65690173
9	Acute necrotizing encephalopathy (HP:0006965)	3.48440429
10	Birth length less than 3rd percentile (HP:0003561)	3.23252448
11	Acute encephalopathy (HP:0006846)	3.19842638
12	Mitochondrial inheritance (HP:0001427)	3.17821167
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02201304
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.00651910
15	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.95023086
16	Macrocytic anemia (HP:0001972)	2.95007620
17	Congenital stationary night blindness (HP:0007642)	2.93123006
18	Increased CSF lactate (HP:0002490)	2.92423453
19	Type II lissencephaly (HP:0007260)	2.90521046
20	Progressive macrocephaly (HP:0004481)	2.80748637
21	Chromsome breakage (HP:0040012)	2.78465298
22	Nephronophthisis (HP:0000090)	2.77519384
23	Increased hepatocellular lipid droplets (HP:0006565)	2.76097656
24	Meckel diverticulum (HP:0002245)	2.73875471
25	Abnormality of the ileum (HP:0001549)	2.64877013
26	Pendular nystagmus (HP:0012043)	2.64475092
27	Hypoplasia of the pons (HP:0012110)	2.64206365
28	Sclerocornea (HP:0000647)	2.62202035
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.59605393
30	Abnormality of alanine metabolism (HP:0010916)	2.59605393
31	Hyperalaninemia (HP:0003348)	2.59605393
32	Lipid accumulation in hepatocytes (HP:0006561)	2.58900409
33	Concave nail (HP:0001598)	2.57220334
34	Pallor (HP:0000980)	2.56711279
35	Abnormality of the pons (HP:0007361)	2.55100666
36	Congenital, generalized hypertrichosis (HP:0004540)	2.49827604
37	3-Methylglutaconic aciduria (HP:0003535)	2.49489385
38	Cystic liver disease (HP:0006706)	2.47467119
39	Absent thumb (HP:0009777)	2.45347916
40	Triphalangeal thumb (HP:0001199)	2.45221699
41	Hepatocellular necrosis (HP:0001404)	2.42431528
42	Septo-optic dysplasia (HP:0100842)	2.41887098
43	Anencephaly (HP:0002323)	2.40516210
44	Anophthalmia (HP:0000528)	2.33841088
45	Bilateral microphthalmos (HP:0007633)	2.33669986
46	Medial flaring of the eyebrow (HP:0010747)	2.29130623
47	Patellar aplasia (HP:0006443)	2.26810559
48	Abnormality of the renal medulla (HP:0100957)	2.25344523
49	Renal Fanconi syndrome (HP:0001994)	2.25314245
50	Aplasia/Hypoplasia of the patella (HP:0006498)	2.22215628
51	Cerebellar dysplasia (HP:0007033)	2.21521457
52	Abnormality of the preputium (HP:0100587)	2.19312462
53	Abnormality of the carotid arteries (HP:0005344)	2.18858922
54	Hepatic necrosis (HP:0002605)	2.16358379
55	Abnormality of chromosome stability (HP:0003220)	2.14422436
56	Abnormality of the renal collecting system (HP:0004742)	2.13368444
57	Male pseudohermaphroditism (HP:0000037)	2.11392003
58	Optic disc pallor (HP:0000543)	2.11148681
59	Duplicated collecting system (HP:0000081)	2.10468530
60	Attenuation of retinal blood vessels (HP:0007843)	2.09890401
61	Increased serum lactate (HP:0002151)	2.05487383
62	Cerebral edema (HP:0002181)	2.00242752
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99921506
64	Abolished electroretinogram (ERG) (HP:0000550)	1.99818160
65	Optic nerve hypoplasia (HP:0000609)	1.99557196
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99112072
67	Absent/shortened dynein arms (HP:0200106)	1.99112072
68	Small intestinal stenosis (HP:0012848)	1.98857579
69	Duodenal stenosis (HP:0100867)	1.98857579
70	Ectopic kidney (HP:0000086)	1.94066719
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.93878155
72	Rib fusion (HP:0000902)	1.92613283
73	Hyperglycinemia (HP:0002154)	1.92596447
74	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91256887
75	Exertional dyspnea (HP:0002875)	1.90467853
76	Furrowed tongue (HP:0000221)	1.90065053
77	Abnormality of the renal cortex (HP:0011035)	1.89631885
78	Clubbing of toes (HP:0100760)	1.89331820
79	Large for gestational age (HP:0001520)	1.88118863
80	Lactic acidosis (HP:0003128)	1.87774854
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87489450
82	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.86072095
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.86072095
84	Short thumb (HP:0009778)	1.85834526
85	Preaxial hand polydactyly (HP:0001177)	1.85525826
86	Esophageal atresia (HP:0002032)	1.84725088
87	Colon cancer (HP:0003003)	1.82682285
88	Retinal dysplasia (HP:0007973)	1.82475404
89	Abnormality of the duodenum (HP:0002246)	1.81629750
90	Congenital hepatic fibrosis (HP:0002612)	1.81571902
91	Gait imbalance (HP:0002141)	1.79984854
92	Sloping forehead (HP:0000340)	1.76209096
93	Polydipsia (HP:0001959)	1.74434881
94	Abnormal drinking behavior (HP:0030082)	1.74434881
95	Maternal diabetes (HP:0009800)	1.74433188
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.73746434
97	Abnormality of renal resorption (HP:0011038)	1.73646163
98	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72702784
99	Postaxial foot polydactyly (HP:0001830)	1.71937653
100	Congenital primary aphakia (HP:0007707)	1.71548810

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.37455252
2	ZAK	4.05625054
3	PNCK	3.31608772
4	VRK2	2.68876524
5	BMPR1B	2.65043862
6	CDC7	2.44192601
7	VRK1	2.39529514
8	ADRBK2	2.26975706
9	FRK	2.22838270
10	GRK1	2.14918244
11	MAPK15	2.12090380
12	WNK4	2.08453735
13	WNK3	2.05346124
14	WEE1	2.03787973
15	BUB1	2.00654144
16	INSRR	1.90830317
17	DYRK2	1.85568562
18	ACVR1B	1.83447436
19	TSSK6	1.73674544
20	NUAK1	1.69853123
21	TNIK	1.65725934
22	NME1	1.65553413
23	PLK4	1.64085530
24	MAPK13	1.49473479
25	MAP4K2	1.40570308
26	MARK1	1.37445883
27	PIK3CA	1.29997185
28	SRPK1	1.25765782
29	BRSK2	1.24972225
30	PINK1	1.23527996
31	CHEK2	1.22802101
32	TGFBR1	1.21958830
33	OXSR1	1.18533447
34	PRKCG	1.15677215
35	CASK	1.14989535
36	MKNK2	1.14582976
37	ADRBK1	1.08663499
38	RPS6KA5	1.04986181
39	STK16	1.04812145
40	DYRK3	1.02829286
41	PLK3	1.02138197
42	MAP3K4	0.97002640
43	BCKDK	0.96382092
44	PLK1	0.95765939
45	ATR	0.94029333
46	TAOK3	0.89217622
47	PASK	0.89107298
48	AURKA	0.85145870
49	MKNK1	0.78789970
50	TAF1	0.78218560
51	AURKB	0.77511627
52	CDK3	0.74600452
53	MAP2K7	0.73406609
54	NEK2	0.72234590
55	DAPK2	0.69169080
56	TTK	0.67624833
57	NME2	0.66136352
58	STK39	0.65576626
59	CAMK1G	0.65360150
60	CSNK2A2	0.64510053
61	MUSK	0.63003541
62	NTRK2	0.62735052
63	CSNK2A1	0.58342369
64	PRKCI	0.58264653
65	PKN1	0.58087590
66	CAMK1D	0.57522080
67	NEK1	0.57499302
68	TRIM28	0.56665719
69	TIE1	0.52508533
70	CAMKK2	0.51871946
71	CDK19	0.50791155
72	STK11	0.50769151
73	ATM	0.50089991
74	CDK8	0.48952764
75	MAPKAPK5	0.48654425
76	CSNK1E	0.48505929
77	PIM1	0.47396589
78	CAMK1	0.47179908
79	TXK	0.46908158
80	PRKACA	0.46703659
81	MARK3	0.46424581
82	PRKCE	0.46049839
83	CSNK1D	0.45729795
84	CCNB1	0.41332338
85	TEC	0.40024684
86	CAMK2A	0.39677894
87	MAP2K6	0.39592939
88	PDK2	0.39523942
89	CSNK1A1	0.39234529
90	TYRO3	0.37486357
91	CSNK1G2	0.36374619
92	CDK7	0.33780645
93	IKBKB	0.33764865
94	PRKACB	0.33705380
95	CHEK1	0.32851727
96	CDK1	0.32151483
97	CSNK1G1	0.30657584
98	KIT	0.30205484
99	EPHB2	0.30197585
100	PRKCQ	0.29939540

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.11957534
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.03868635
3	Parkinsons disease_Homo sapiens_hsa05012	3.41315043
4	RNA polymerase_Homo sapiens_hsa03020	2.99816529
5	Homologous recombination_Homo sapiens_hsa03440	2.82379855
6	Huntingtons disease_Homo sapiens_hsa05016	2.52035240
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48916543
8	Alzheimers disease_Homo sapiens_hsa05010	2.23725050
9	DNA replication_Homo sapiens_hsa03030	2.23232365
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22394755
11	Mismatch repair_Homo sapiens_hsa03430	2.22023923
12	One carbon pool by folate_Homo sapiens_hsa00670	2.15727026
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.12675672
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10659256
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.97839034
16	Protein export_Homo sapiens_hsa03060	1.95440557
17	Phototransduction_Homo sapiens_hsa04744	1.87271846
18	Sulfur relay system_Homo sapiens_hsa04122	1.85502765
19	Basal transcription factors_Homo sapiens_hsa03022	1.73736010
20	Nicotine addiction_Homo sapiens_hsa05033	1.65125365
21	Spliceosome_Homo sapiens_hsa03040	1.60726438
22	Proteasome_Homo sapiens_hsa03050	1.57017115
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.53046066
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.52328064
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.51459843
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49306808
27	RNA degradation_Homo sapiens_hsa03018	1.44831558
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40732487
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40555670
30	Base excision repair_Homo sapiens_hsa03410	1.40307715
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.37882874
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36921111
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30877473
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22769923
35	RNA transport_Homo sapiens_hsa03013	1.22460303
36	Purine metabolism_Homo sapiens_hsa00230	1.16829431
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14491234
38	Butanoate metabolism_Homo sapiens_hsa00650	1.08992873
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08491257
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04853927
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.01625470
42	Caffeine metabolism_Homo sapiens_hsa00232	0.98484808
43	Taste transduction_Homo sapiens_hsa04742	0.97575422
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93530932
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91372860
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.87352116
47	Basal cell carcinoma_Homo sapiens_hsa05217	0.85321134
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.84697044
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79802952
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73167030
51	Olfactory transduction_Homo sapiens_hsa04740	0.72395667
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.72273555
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71929425
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71088071
55	Metabolic pathways_Homo sapiens_hsa01100	0.70907816
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69081002
57	Morphine addiction_Homo sapiens_hsa05032	0.65129485
58	Folate biosynthesis_Homo sapiens_hsa00790	0.64780563
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.63601863
60	Propanoate metabolism_Homo sapiens_hsa00640	0.60806427
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59178120
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58375371
63	Cell cycle_Homo sapiens_hsa04110	0.58303418
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.58088325
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57025380
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56285081
67	Alcoholism_Homo sapiens_hsa05034	0.55229385
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55193957
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54505484
70	Retinol metabolism_Homo sapiens_hsa00830	0.53238201
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52916860
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50657929
73	GABAergic synapse_Homo sapiens_hsa04727	0.50560508
74	Peroxisome_Homo sapiens_hsa04146	0.50509383
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.48318463
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47104769
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44133448
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.44024715
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43685338
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41875243
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40792117
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38926549
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.37109521
84	Sulfur metabolism_Homo sapiens_hsa00920	0.36397928
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.36281133
86	Serotonergic synapse_Homo sapiens_hsa04726	0.35751000
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35575027
88	Circadian entrainment_Homo sapiens_hsa04713	0.32772085
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30258194
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29337549
91	Glutathione metabolism_Homo sapiens_hsa00480	0.27367014
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26834917
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.26777869
94	Insulin secretion_Homo sapiens_hsa04911	0.26600302
95	Regulation of autophagy_Homo sapiens_hsa04140	0.26234682
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22947829
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.21643443
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21314539
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.20723757
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.18945752

EMC3-AS1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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