

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.26685059 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.85787564 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.85787564 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.48930529 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 5.33199734 |
| 6 | respiratory electron transport chain (GO:0022904) | 5.01571007 |
| 7 | proteasome assembly (GO:0043248) | 4.98279282 |
| 8 | electron transport chain (GO:0022900) | 4.90394177 |
| 9 | protein complex biogenesis (GO:0070271) | 4.73126882 |
| 10 | cullin deneddylation (GO:0010388) | 4.50758814 |
| 11 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.48416950 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.48416950 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 4.48416950 |
| 14 | regulation of mitochondrial translation (GO:0070129) | 4.44194644 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.40771950 |
| 16 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.40058439 |
| 17 | protein deneddylation (GO:0000338) | 4.31795737 |
| 18 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 4.09310590 |
| 19 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.08066434 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.03107775 |
| 21 | protein targeting to mitochondrion (GO:0006626) | 4.02566737 |
| 22 | protein neddylation (GO:0045116) | 3.95243665 |
| 23 | establishment of protein localization to mitochondrion (GO:0072655) | 3.95142314 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.90023812 |
| 25 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.84453778 |
| 26 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.84453778 |
| 27 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.81497455 |
| 28 | NADH metabolic process (GO:0006734) | 3.79106292 |
| 29 | protein localization to mitochondrion (GO:0070585) | 3.74324959 |
| 30 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.74209458 |
| 31 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.74209458 |
| 32 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.72046233 |
| 33 | termination of RNA polymerase III transcription (GO:0006386) | 3.72046233 |
| 34 | L-methionine salvage (GO:0071267) | 3.71928927 |
| 35 | L-methionine biosynthetic process (GO:0071265) | 3.71928927 |
| 36 | amino acid salvage (GO:0043102) | 3.71928927 |
| 37 | respiratory chain complex IV assembly (GO:0008535) | 3.69546189 |
| 38 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.67987464 |
| 39 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.65644950 |
| 40 | pseudouridine synthesis (GO:0001522) | 3.65607934 |
| 41 | DNA deamination (GO:0045006) | 3.63608439 |
| 42 | synaptic vesicle exocytosis (GO:0016079) | 3.60387465 |
| 43 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.59002212 |
| 44 | oxidative phosphorylation (GO:0006119) | 3.57030772 |
| 45 | hydrogen ion transmembrane transport (GO:1902600) | 3.54022414 |
| 46 | negative regulation of ligase activity (GO:0051352) | 3.52295295 |
| 47 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.52295295 |
| 48 | cytochrome complex assembly (GO:0017004) | 3.51257760 |
| 49 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.49530694 |
| 50 | platelet dense granule organization (GO:0060155) | 3.48752250 |
| 51 | transferrin transport (GO:0033572) | 3.43106648 |
| 52 | 7-methylguanosine mRNA capping (GO:0006370) | 3.41995721 |
| 53 | protein-cofactor linkage (GO:0018065) | 3.40678617 |
| 54 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.36792312 |
| 55 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.35527140 |
| 56 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.35527140 |
| 57 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.35270207 |
| 58 | GDP-mannose metabolic process (GO:0019673) | 3.33180380 |
| 59 | neuronal action potential propagation (GO:0019227) | 3.33048138 |
| 60 | GTP biosynthetic process (GO:0006183) | 3.32575053 |
| 61 | RNA capping (GO:0036260) | 3.32455548 |
| 62 | 7-methylguanosine RNA capping (GO:0009452) | 3.32455548 |
| 63 | rRNA modification (GO:0000154) | 3.30665795 |
| 64 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.29835326 |
| 65 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.29742448 |
| 66 | positive regulation of mitochondrial fission (GO:0090141) | 3.29122164 |
| 67 | ATP biosynthetic process (GO:0006754) | 3.29052547 |
| 68 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.28693202 |
| 69 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.28693202 |
| 70 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.28693202 |
| 71 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.27806853 |
| 72 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.27806853 |
| 73 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.27521855 |
| 74 | behavioral response to nicotine (GO:0035095) | 3.25104446 |
| 75 | regulation of cellular amine metabolic process (GO:0033238) | 3.18511344 |
| 76 | regulation of cellular respiration (GO:0043457) | 3.17177467 |
| 77 | positive regulation of ligase activity (GO:0051351) | 3.16839331 |
| 78 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.16199626 |
| 79 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.16199626 |
| 80 | DNA damage response, detection of DNA damage (GO:0042769) | 3.14446366 |
| 81 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.14098543 |
| 82 | trivalent inorganic cation transport (GO:0072512) | 3.13537223 |
| 83 | ferric iron transport (GO:0015682) | 3.13537223 |
| 84 | base-excision repair, AP site formation (GO:0006285) | 3.12643065 |
| 85 | proton transport (GO:0015992) | 3.11380542 |
| 86 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.11313174 |
| 87 | inner mitochondrial membrane organization (GO:0007007) | 3.09450264 |
| 88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.08267145 |
| 89 | DNA double-strand break processing (GO:0000729) | 3.07554322 |
| 90 | mannosylation (GO:0097502) | 3.06004040 |
| 91 | hydrogen transport (GO:0006818) | 3.04879898 |
| 92 | metallo-sulfur cluster assembly (GO:0031163) | 3.04629148 |
| 93 | iron-sulfur cluster assembly (GO:0016226) | 3.04629148 |
| 94 | GMP metabolic process (GO:0046037) | 3.03066634 |
| 95 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.00709224 |
| 96 | viral mRNA export from host cell nucleus (GO:0046784) | 2.97123557 |
| 97 | regulation of oxidative phosphorylation (GO:0002082) | 2.96180222 |
| 98 | intracellular protein transmembrane import (GO:0044743) | 2.95400317 |
| 99 | mitochondrial transport (GO:0006839) | 2.94773255 |
| 100 | tRNA processing (GO:0008033) | 2.91024029 |
| 101 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.89806040 |
| 102 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.88313685 |
| 103 | aldehyde catabolic process (GO:0046185) | 2.87344661 |
| 104 | dopamine transport (GO:0015872) | 2.87078226 |
| 105 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.84389500 |
| 106 | ubiquinone biosynthetic process (GO:0006744) | 2.84297078 |
| 107 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.83468855 |
| 108 | purine nucleobase biosynthetic process (GO:0009113) | 2.82571702 |
| 109 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.80829287 |
| 110 | UTP biosynthetic process (GO:0006228) | 2.80659701 |
| 111 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.80145250 |
| 112 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.79626691 |
| 113 | glutamate secretion (GO:0014047) | 2.77089569 |
| 114 | peptidyl-histidine modification (GO:0018202) | 2.75945482 |
| 115 | formation of translation preinitiation complex (GO:0001731) | 2.75194631 |
| 116 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.74236268 |
| 117 | branched-chain amino acid catabolic process (GO:0009083) | 2.73055055 |
| 118 | cellular component biogenesis (GO:0044085) | 2.71418756 |
| 119 | regulation of ligase activity (GO:0051340) | 2.71035165 |
| 120 | protein localization to synapse (GO:0035418) | 2.70518015 |
| 121 | regulation of cilium movement (GO:0003352) | 2.65764554 |
| 122 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.65462001 |
| 123 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.65462001 |
| 124 | anterograde synaptic vesicle transport (GO:0048490) | 2.65137831 |
| 125 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.64839605 |
| 126 | maturation of 5.8S rRNA (GO:0000460) | 2.64291712 |
| 127 | ubiquinone metabolic process (GO:0006743) | 2.62063817 |
| 128 | positive regulation of cell cycle arrest (GO:0071158) | 2.61472091 |
| 129 | spliceosomal snRNP assembly (GO:0000387) | 2.61448691 |
| 130 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.60136332 |
| 131 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.59310279 |
| 132 | GPI anchor metabolic process (GO:0006505) | 2.59018353 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.86609953 |
| 2 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.46715098 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.34055036 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.27124004 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.02694547 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.85634077 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.75516648 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.37282306 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.21050601 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.99195617 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.97331166 |
| 12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.86416926 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.82469126 |
| 14 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.78976990 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.63008242 |
| 16 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.58030969 |
| 17 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.53820256 |
| 18 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.48907104 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.41858355 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.36261630 |
| 21 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.33086344 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.32104467 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.28276372 |
| 24 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.05955096 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.03941569 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.98708091 |
| 27 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.98652464 |
| 28 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.95209857 |
| 29 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.95094926 |
| 30 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.82657032 |
| 31 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.78920294 |
| 32 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.72534683 |
| 33 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.69090329 |
| 34 | EWS_26573619_Chip-Seq_HEK293_Human | 1.68677892 |
| 35 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.64454157 |
| 36 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.64375111 |
| 37 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.63818835 |
| 38 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.63663516 |
| 39 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.61747859 |
| 40 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.61067345 |
| 41 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.60426604 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.55654760 |
| 43 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54031708 |
| 44 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.51739631 |
| 45 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.49625657 |
| 46 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.49420637 |
| 47 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.48322546 |
| 48 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.47027380 |
| 49 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.46084447 |
| 50 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.42630124 |
| 51 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.42386484 |
| 52 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.42107682 |
| 53 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.39744537 |
| 54 | VDR_22108803_ChIP-Seq_LS180_Human | 1.38734535 |
| 55 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.37286182 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36785526 |
| 57 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.36599793 |
| 58 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.35865048 |
| 59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.33561783 |
| 60 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.32357381 |
| 61 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.28711472 |
| 62 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.26934213 |
| 63 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26645249 |
| 64 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.25526858 |
| 65 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.22803054 |
| 66 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21600793 |
| 67 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.18031952 |
| 68 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.12581858 |
| 69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12356661 |
| 70 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.12312510 |
| 71 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.11320634 |
| 72 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.10028041 |
| 73 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07843094 |
| 74 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.07579807 |
| 75 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.05614553 |
| 76 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05142230 |
| 77 | AR_20517297_ChIP-Seq_VCAP_Human | 1.03432572 |
| 78 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.03282048 |
| 79 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.03282048 |
| 80 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.03186693 |
| 81 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.02668615 |
| 82 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.02544709 |
| 83 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.02544709 |
| 84 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00637530 |
| 85 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.99972316 |
| 86 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.99684617 |
| 87 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.97423416 |
| 88 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97271703 |
| 89 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.97258067 |
| 90 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.93523400 |
| 91 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.92260390 |
| 92 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.92181035 |
| 93 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91058631 |
| 94 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89553905 |
| 95 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.89200421 |
| 96 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.88007373 |
| 97 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.85882569 |
| 98 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.84504605 |
| 99 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82947838 |
| 100 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.82875676 |
| 101 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.82584669 |
| 102 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.82386863 |
| 103 | JUN_21703547_ChIP-Seq_K562_Human | 0.81806699 |
| 104 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.81523022 |
| 105 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.81370923 |
| 106 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.81332997 |
| 107 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.81020168 |
| 108 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.79308414 |
| 109 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.79004722 |
| 110 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.78612009 |
| 111 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.78606554 |
| 112 | FUS_26573619_Chip-Seq_HEK293_Human | 0.77406390 |
| 113 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.76658459 |
| 114 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.76390454 |
| 115 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.75783447 |
| 116 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.75472623 |
| 117 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.74901068 |
| 118 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.74684861 |
| 119 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.73486831 |
| 120 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.73403779 |
| 121 | P300_19829295_ChIP-Seq_ESCs_Human | 0.72201864 |
| 122 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.71990881 |
| 123 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.71793756 |
| 124 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71253833 |
| 125 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.70438092 |
| 126 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.67804633 |
| 127 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.67733852 |
| 128 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.67363489 |
| 129 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.67212419 |
| 130 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.66879669 |
| 131 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.66422237 |
| 132 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.66153019 |
| 133 | NCOR_22424771_ChIP-Seq_293T_Human | 0.66018263 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.44362425 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 3.46481476 |
| 3 | MP0001968_abnormal_touch/_nociception | 3.11458102 |
| 4 | MP0002736_abnormal_nociception_after | 3.07189691 |
| 5 | MP0001984_abnormal_olfaction | 2.91410694 |
| 6 | MP0001529_abnormal_vocalization | 2.89607585 |
| 7 | MP0009046_muscle_twitch | 2.85804428 |
| 8 | MP0003635_abnormal_synaptic_transmissio | 2.80883050 |
| 9 | MP0004270_analgesia | 2.74057385 |
| 10 | MP0008058_abnormal_DNA_repair | 2.63383514 |
| 11 | MP0009745_abnormal_behavioral_response | 2.62259670 |
| 12 | MP0002102_abnormal_ear_morphology | 2.60420452 |
| 13 | MP0002064_seizures | 2.57173384 |
| 14 | MP0002735_abnormal_chemical_nociception | 2.54420397 |
| 15 | MP0002272_abnormal_nervous_system | 2.47347623 |
| 16 | MP0002734_abnormal_mechanical_nocicepti | 2.46731373 |
| 17 | MP0006072_abnormal_retinal_apoptosis | 2.40526351 |
| 18 | MP0006276_abnormal_autonomic_nervous | 2.32318256 |
| 19 | MP0006036_abnormal_mitochondrial_physio | 2.28473270 |
| 20 | MP0003011_delayed_dark_adaptation | 2.27238761 |
| 21 | MP0002063_abnormal_learning/memory/cond | 2.26207186 |
| 22 | MP0001905_abnormal_dopamine_level | 2.22705737 |
| 23 | MP0003879_abnormal_hair_cell | 2.21348284 |
| 24 | MP0006292_abnormal_olfactory_placode | 2.12440083 |
| 25 | MP0002572_abnormal_emotion/affect_behav | 2.12302647 |
| 26 | MP0002876_abnormal_thyroid_physiology | 2.09052942 |
| 27 | MP0002822_catalepsy | 2.08070194 |
| 28 | MP0008875_abnormal_xenobiotic_pharmacok | 2.07235483 |
| 29 | MP0004142_abnormal_muscle_tone | 2.04997395 |
| 30 | MP0002733_abnormal_thermal_nociception | 1.95872780 |
| 31 | MP0001440_abnormal_grooming_behavior | 1.95782057 |
| 32 | MP0006035_abnormal_mitochondrial_morpho | 1.94344553 |
| 33 | MP0003806_abnormal_nucleotide_metabolis | 1.92451347 |
| 34 | MP0003693_abnormal_embryo_hatching | 1.90432220 |
| 35 | MP0008260_abnormal_autophagy | 1.88734721 |
| 36 | MP0001501_abnormal_sleep_pattern | 1.88107017 |
| 37 | MP0001970_abnormal_pain_threshold | 1.86547256 |
| 38 | MP0002067_abnormal_sensory_capabilities | 1.85075461 |
| 39 | MP0003195_calcinosis | 1.83298295 |
| 40 | MP0003329_amyloid_beta_deposits | 1.76234876 |
| 41 | MP0005253_abnormal_eye_physiology | 1.75035494 |
| 42 | MP0001542_abnormal_bone_strength | 1.72385294 |
| 43 | MP0003787_abnormal_imprinting | 1.67578883 |
| 44 | MP0003718_maternal_effect | 1.65129797 |
| 45 | MP0001986_abnormal_taste_sensitivity | 1.65101672 |
| 46 | MP0002184_abnormal_innervation | 1.59945598 |
| 47 | MP0001486_abnormal_startle_reflex | 1.59051378 |
| 48 | MP0001188_hyperpigmentation | 1.58412434 |
| 49 | MP0005386_behavior/neurological_phenoty | 1.46712876 |
| 50 | MP0004924_abnormal_behavior | 1.46712876 |
| 51 | MP0002938_white_spotting | 1.44620162 |
| 52 | MP0003646_muscle_fatigue | 1.43280297 |
| 53 | MP0002234_abnormal_pharynx_morphology | 1.35508728 |
| 54 | MP0003136_yellow_coat_color | 1.32383991 |
| 55 | MP0003121_genomic_imprinting | 1.32152848 |
| 56 | MP0003186_abnormal_redox_activity | 1.30239426 |
| 57 | MP0008995_early_reproductive_senescence | 1.29030096 |
| 58 | MP0005646_abnormal_pituitary_gland | 1.26788242 |
| 59 | MP0005423_abnormal_somatic_nervous | 1.25410550 |
| 60 | MP0004133_heterotaxia | 1.24859183 |
| 61 | MP0008877_abnormal_DNA_methylation | 1.23793032 |
| 62 | MP0008872_abnormal_physiological_respon | 1.20631657 |
| 63 | MP0002837_dystrophic_cardiac_calcinosis | 1.20463128 |
| 64 | MP0004215_abnormal_myocardial_fiber | 1.18439722 |
| 65 | MP0004957_abnormal_blastocyst_morpholog | 1.18221217 |
| 66 | MP0001764_abnormal_homeostasis | 1.16082655 |
| 67 | MP0002557_abnormal_social/conspecific_i | 1.14231500 |
| 68 | MP0000631_abnormal_neuroendocrine_gland | 1.13134812 |
| 69 | MP0002066_abnormal_motor_capabilities/c | 1.12340630 |
| 70 | MP0009379_abnormal_foot_pigmentation | 1.12196572 |
| 71 | MP0002090_abnormal_vision | 1.10463508 |
| 72 | MP0004145_abnormal_muscle_electrophysio | 1.09731797 |
| 73 | MP0005084_abnormal_gallbladder_morpholo | 1.09222106 |
| 74 | MP0005551_abnormal_eye_electrophysiolog | 1.08394932 |
| 75 | MP0002160_abnormal_reproductive_system | 1.06973911 |
| 76 | MP0010094_abnormal_chromosome_stability | 1.03299552 |
| 77 | MP0005379_endocrine/exocrine_gland_phen | 1.03288011 |
| 78 | MP0005075_abnormal_melanosome_morpholog | 1.01437029 |
| 79 | MP0004811_abnormal_neuron_physiology | 1.00852724 |
| 80 | MP0002229_neurodegeneration | 1.00583782 |
| 81 | MP0001485_abnormal_pinna_reflex | 1.00509192 |
| 82 | MP0005499_abnormal_olfactory_system | 1.00493007 |
| 83 | MP0005394_taste/olfaction_phenotype | 1.00493007 |
| 84 | MP0004885_abnormal_endolymph | 0.98527334 |
| 85 | MP0003878_abnormal_ear_physiology | 0.97652631 |
| 86 | MP0005377_hearing/vestibular/ear_phenot | 0.97652631 |
| 87 | MP0002095_abnormal_skin_pigmentation | 0.96692254 |
| 88 | MP0009697_abnormal_copulation | 0.96546429 |
| 89 | MP0001963_abnormal_hearing_physiology | 0.95278487 |
| 90 | MP0002882_abnormal_neuron_morphology | 0.95226531 |
| 91 | MP0002653_abnormal_ependyma_morphology | 0.95137356 |
| 92 | MP0000372_irregular_coat_pigmentation | 0.94628808 |
| 93 | MP0008569_lethality_at_weaning | 0.93687472 |
| 94 | MP0003123_paternal_imprinting | 0.92898864 |
| 95 | MP0002163_abnormal_gland_morphology | 0.90728379 |
| 96 | MP0000647_abnormal_sebaceous_gland | 0.89940140 |
| 97 | MP0008789_abnormal_olfactory_epithelium | 0.89372787 |
| 98 | MP0002210_abnormal_sex_determination | 0.89308488 |
| 99 | MP0003786_premature_aging | 0.88056223 |
| 100 | MP0005410_abnormal_fertilization | 0.87501151 |
| 101 | MP0001929_abnormal_gametogenesis | 0.87334469 |
| 102 | MP0002277_abnormal_respiratory_mucosa | 0.86437394 |
| 103 | MP0008932_abnormal_embryonic_tissue | 0.85806852 |
| 104 | MP0003567_abnormal_fetal_cardiomyocyte | 0.85803702 |
| 105 | MP0002638_abnormal_pupillary_reflex | 0.84442567 |
| 106 | MP0000749_muscle_degeneration | 0.84158802 |
| 107 | MP0002332_abnormal_exercise_endurance | 0.82539356 |
| 108 | MP0004036_abnormal_muscle_relaxation | 0.81604105 |
| 109 | MP0004484_altered_response_of | 0.80716815 |
| 110 | MP0005195_abnormal_posterior_eye | 0.79710111 |
| 111 | MP0005645_abnormal_hypothalamus_physiol | 0.79706120 |
| 112 | MP0001919_abnormal_reproductive_system | 0.79139623 |
| 113 | MP0008007_abnormal_cellular_replicative | 0.79130868 |
| 114 | MP0002752_abnormal_somatic_nervous | 0.78798336 |
| 115 | MP0000653_abnormal_sex_gland | 0.78640315 |
| 116 | MP0005389_reproductive_system_phenotype | 0.78609923 |
| 117 | MP0008775_abnormal_heart_ventricle | 0.78360796 |
| 118 | MP0000358_abnormal_cell_content/ | 0.77651729 |
| 119 | MP0000955_abnormal_spinal_cord | 0.77324164 |
| 120 | MP0005636_abnormal_mineral_homeostasis | 0.76973980 |
| 121 | MP0005171_absent_coat_pigmentation | 0.76544727 |
| 122 | MP0000049_abnormal_middle_ear | 0.76309444 |
| 123 | MP0000751_myopathy | 0.75452167 |
| 124 | MP0005332_abnormal_amino_acid | 0.74050944 |
| 125 | MP0004043_abnormal_pH_regulation | 0.73616729 |
| 126 | MP0003122_maternal_imprinting | 0.73522612 |
| 127 | MP0002909_abnormal_adrenal_gland | 0.72659044 |
| 128 | MP0003137_abnormal_impulse_conducting | 0.72260325 |
| 129 | MP0004147_increased_porphyrin_level | 0.70956038 |
| 130 | MP0001664_abnormal_digestion | 0.68923377 |
| 131 | MP0000604_amyloidosis | 0.68751492 |
| 132 | MP0010386_abnormal_urinary_bladder | 0.68218016 |
| 133 | MP0005535_abnormal_body_temperature | 0.66283790 |
| 134 | MP0002751_abnormal_autonomic_nervous | 0.65131013 |
| 135 | MP0000681_abnormal_thyroid_gland | 0.64096741 |
| 136 | MP0005330_cardiomyopathy | 0.63988986 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.97714543 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.56739352 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.32596262 |
| 4 | Acute encephalopathy (HP:0006846) | 4.88978761 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.88495870 |
| 6 | Increased CSF lactate (HP:0002490) | 4.87410499 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.84278153 |
| 8 | Focal motor seizures (HP:0011153) | 4.60240982 |
| 9 | Hepatic necrosis (HP:0002605) | 4.14194362 |
| 10 | Myokymia (HP:0002411) | 3.79157370 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.67321734 |
| 12 | Increased serum pyruvate (HP:0003542) | 3.58605831 |
| 13 | Abnormality of glycolysis (HP:0004366) | 3.58605831 |
| 14 | Atonic seizures (HP:0010819) | 3.55768540 |
| 15 | Lactic acidosis (HP:0003128) | 3.55031673 |
| 16 | Increased serum lactate (HP:0002151) | 3.53988888 |
| 17 | Abnormality of alanine metabolism (HP:0010916) | 3.50344350 |
| 18 | Hyperalaninemia (HP:0003348) | 3.50344350 |
| 19 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.50344350 |
| 20 | Cerebral hypomyelination (HP:0006808) | 3.49921631 |
| 21 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.48610932 |
| 22 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.48610932 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 3.45759036 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.40580143 |
| 25 | Delusions (HP:0000746) | 3.38291706 |
| 26 | Respiratory failure (HP:0002878) | 3.32029540 |
| 27 | Cerebral edema (HP:0002181) | 3.31552288 |
| 28 | Neuroendocrine neoplasm (HP:0100634) | 3.17856850 |
| 29 | Exercise intolerance (HP:0003546) | 3.16375993 |
| 30 | Lipid accumulation in hepatocytes (HP:0006561) | 3.16054377 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15699162 |
| 32 | Optic disc pallor (HP:0000543) | 3.08098365 |
| 33 | Poor suck (HP:0002033) | 3.08037307 |
| 34 | Abnormality of midbrain morphology (HP:0002418) | 3.00185349 |
| 35 | Molar tooth sign on MRI (HP:0002419) | 3.00185349 |
| 36 | Pheochromocytoma (HP:0002666) | 2.99412455 |
| 37 | Epileptic encephalopathy (HP:0200134) | 2.98955575 |
| 38 | CNS demyelination (HP:0007305) | 2.96444444 |
| 39 | Renal Fanconi syndrome (HP:0001994) | 2.92893404 |
| 40 | Increased intramyocellular lipid droplets (HP:0012240) | 2.90339857 |
| 41 | Emotional lability (HP:0000712) | 2.90312373 |
| 42 | Absence seizures (HP:0002121) | 2.87650279 |
| 43 | Unsteady gait (HP:0002317) | 2.83733020 |
| 44 | Methylmalonic acidemia (HP:0002912) | 2.75236492 |
| 45 | True hermaphroditism (HP:0010459) | 2.69447330 |
| 46 | Febrile seizures (HP:0002373) | 2.67900651 |
| 47 | Dialeptic seizures (HP:0011146) | 2.62779696 |
| 48 | Leukodystrophy (HP:0002415) | 2.61834536 |
| 49 | Hyperventilation (HP:0002883) | 2.58231452 |
| 50 | Focal seizures (HP:0007359) | 2.43532894 |
| 51 | Nephronophthisis (HP:0000090) | 2.38107554 |
| 52 | Abolished electroretinogram (ERG) (HP:0000550) | 2.37066516 |
| 53 | Congenital stationary night blindness (HP:0007642) | 2.35884895 |
| 54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.35873116 |
| 55 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.35873116 |
| 56 | Abnormal protein glycosylation (HP:0012346) | 2.35873116 |
| 57 | Abnormal glycosylation (HP:0012345) | 2.35873116 |
| 58 | Visual hallucinations (HP:0002367) | 2.33468859 |
| 59 | Respiratory difficulties (HP:0002880) | 2.32435379 |
| 60 | Medial flaring of the eyebrow (HP:0010747) | 2.32024227 |
| 61 | Increased muscle lipid content (HP:0009058) | 2.31181085 |
| 62 | Lethargy (HP:0001254) | 2.24119082 |
| 63 | Exertional dyspnea (HP:0002875) | 2.20216550 |
| 64 | Type II lissencephaly (HP:0007260) | 2.12010873 |
| 65 | CNS hypomyelination (HP:0003429) | 2.11935753 |
| 66 | Microvesicular hepatic steatosis (HP:0001414) | 2.11336269 |
| 67 | Renal cortical cysts (HP:0000803) | 2.10350811 |
| 68 | Generalized tonic-clonic seizures (HP:0002069) | 2.10110140 |
| 69 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.09219887 |
| 70 | Pancreatic fibrosis (HP:0100732) | 2.08489518 |
| 71 | X-linked dominant inheritance (HP:0001423) | 2.08439074 |
| 72 | Pendular nystagmus (HP:0012043) | 2.07469592 |
| 73 | Gait imbalance (HP:0002141) | 2.07266726 |
| 74 | Abnormal hair whorl (HP:0010721) | 2.07238302 |
| 75 | Abnormality of the anterior horn cell (HP:0006802) | 2.05392938 |
| 76 | Degeneration of anterior horn cells (HP:0002398) | 2.05392938 |
| 77 | Congenital primary aphakia (HP:0007707) | 2.03915850 |
| 78 | Nephrogenic diabetes insipidus (HP:0009806) | 2.02912696 |
| 79 | Abnormality of serum amino acid levels (HP:0003112) | 2.01955856 |
| 80 | Sclerocornea (HP:0000647) | 2.01461402 |
| 81 | Generalized aminoaciduria (HP:0002909) | 2.00309355 |
| 82 | Abnormality of the labia minora (HP:0012880) | 1.99312594 |
| 83 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.98924926 |
| 84 | Dysautonomia (HP:0002459) | 1.97043431 |
| 85 | Progressive external ophthalmoplegia (HP:0000590) | 1.96417773 |
| 86 | Abnormality of the renal cortex (HP:0011035) | 1.95621329 |
| 87 | Abnormality of renal resorption (HP:0011038) | 1.94300590 |
| 88 | Postnatal microcephaly (HP:0005484) | 1.91418109 |
| 89 | Abnormality of the renal medulla (HP:0100957) | 1.89622630 |
| 90 | Congenital, generalized hypertrichosis (HP:0004540) | 1.87168913 |
| 91 | Rough bone trabeculation (HP:0100670) | 1.86745475 |
| 92 | Progressive microcephaly (HP:0000253) | 1.86125671 |
| 93 | Ventricular fibrillation (HP:0001663) | 1.85821688 |
| 94 | Retinal dysplasia (HP:0007973) | 1.85503458 |
| 95 | Microretrognathia (HP:0000308) | 1.84619061 |
| 96 | Limb dystonia (HP:0002451) | 1.84497015 |
| 97 | Polyphagia (HP:0002591) | 1.81753168 |
| 98 | Colon cancer (HP:0003003) | 1.81250211 |
| 99 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.80002817 |
| 100 | Dicarboxylic aciduria (HP:0003215) | 1.80002817 |
| 101 | Death in infancy (HP:0001522) | 1.78369168 |
| 102 | Abnormal number of erythroid precursors (HP:0012131) | 1.78093597 |
| 103 | Fetal akinesia sequence (HP:0001989) | 1.77981929 |
| 104 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.77663238 |
| 105 | Gliosis (HP:0002171) | 1.75938307 |
| 106 | Inability to walk (HP:0002540) | 1.75842006 |
| 107 | Aplastic anemia (HP:0001915) | 1.74571295 |
| 108 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.74301431 |
| 109 | Anxiety (HP:0000739) | 1.73867426 |
| 110 | Methylmalonic aciduria (HP:0012120) | 1.72754504 |
| 111 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.70956603 |
| 112 | Abnormal pupillary function (HP:0007686) | 1.69963126 |
| 113 | Pancytopenia (HP:0001876) | 1.69355401 |
| 114 | Birth length less than 3rd percentile (HP:0003561) | 1.69052995 |
| 115 | Abnormality of glycine metabolism (HP:0010895) | 1.68949808 |
| 116 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.68949808 |
| 117 | Short tibia (HP:0005736) | 1.68700135 |
| 118 | Vaginal atresia (HP:0000148) | 1.68190009 |
| 119 | Oligomenorrhea (HP:0000876) | 1.67025967 |
| 120 | Genital tract atresia (HP:0001827) | 1.66282158 |
| 121 | Hyperglycinuria (HP:0003108) | 1.65319361 |
| 122 | Breast hypoplasia (HP:0003187) | 1.64984495 |
| 123 | Pancreatic cysts (HP:0001737) | 1.64499890 |
| 124 | Hypothermia (HP:0002045) | 1.64345287 |
| 125 | Hypoplasia of the uterus (HP:0000013) | 1.63155442 |
| 126 | Progressive inability to walk (HP:0002505) | 1.63026150 |
| 127 | Hyperglycinemia (HP:0002154) | 1.62927510 |
| 128 | Attenuation of retinal blood vessels (HP:0007843) | 1.62626496 |
| 129 | Gout (HP:0001997) | 1.62251006 |
| 130 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.62216578 |
| 131 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.61782393 |
| 132 | Irregular epiphyses (HP:0010582) | 1.61167498 |
| 133 | Carpal bone hypoplasia (HP:0001498) | 1.61006764 |
| 134 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.59850508 |
| 135 | Reduced antithrombin III activity (HP:0001976) | 1.59802313 |
| 136 | Type I transferrin isoform profile (HP:0003642) | 1.59777130 |
| 137 | Type 2 muscle fiber atrophy (HP:0003554) | 1.59291513 |
| 138 | Premature ovarian failure (HP:0008209) | 1.59288518 |
| 139 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.58708644 |
| 140 | Abnormality of urine glucose concentration (HP:0011016) | 1.58275192 |
| 141 | Glycosuria (HP:0003076) | 1.58275192 |
| 142 | Spastic paraparesis (HP:0002313) | 1.57917996 |
| 143 | Progressive cerebellar ataxia (HP:0002073) | 1.56881761 |
| 144 | Patent foramen ovale (HP:0001655) | 1.56171546 |
| 145 | Blindness (HP:0000618) | 1.55760282 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NEK1 | 4.60646542 |
| 2 | ARAF | 3.46918854 |
| 3 | MAP3K12 | 3.44468651 |
| 4 | CASK | 3.01518546 |
| 5 | NME1 | 2.87892368 |
| 6 | STK16 | 2.80483818 |
| 7 | VRK2 | 2.73910029 |
| 8 | BUB1 | 2.61588632 |
| 9 | MAP4K2 | 2.43267453 |
| 10 | WNK3 | 2.34869608 |
| 11 | FRK | 2.32119092 |
| 12 | TRIM28 | 2.28927552 |
| 13 | MAP2K7 | 2.15235199 |
| 14 | AKT3 | 2.08270001 |
| 15 | PLK2 | 2.00294903 |
| 16 | EPHA4 | 1.98297168 |
| 17 | CCNB1 | 1.95243550 |
| 18 | NUAK1 | 1.94365171 |
| 19 | BRAF | 1.94318014 |
| 20 | EIF2AK1 | 1.93494083 |
| 21 | GRK1 | 1.86714670 |
| 22 | CDK19 | 1.79131288 |
| 23 | WEE1 | 1.73959520 |
| 24 | PIM2 | 1.73402072 |
| 25 | TLK1 | 1.70243374 |
| 26 | NME2 | 1.66482337 |
| 27 | PLK4 | 1.63556652 |
| 28 | TSSK6 | 1.59720198 |
| 29 | MINK1 | 1.57882643 |
| 30 | DAPK1 | 1.52705349 |
| 31 | NTRK3 | 1.52561206 |
| 32 | MAP3K11 | 1.50785507 |
| 33 | GRK5 | 1.49077404 |
| 34 | RIPK4 | 1.45963775 |
| 35 | PBK | 1.44533602 |
| 36 | PINK1 | 1.43126571 |
| 37 | EIF2AK3 | 1.30687454 |
| 38 | CSNK1G1 | 1.26631424 |
| 39 | ACVR1B | 1.24907107 |
| 40 | ERBB3 | 1.19950398 |
| 41 | WNK4 | 1.19671668 |
| 42 | MAP3K4 | 1.19197893 |
| 43 | MAP3K9 | 1.19069289 |
| 44 | TXK | 1.18883623 |
| 45 | CSNK1A1L | 1.18769822 |
| 46 | PNCK | 1.18535736 |
| 47 | BCR | 1.17880281 |
| 48 | INSRR | 1.17772446 |
| 49 | CAMKK2 | 1.16663354 |
| 50 | DAPK2 | 1.14743791 |
| 51 | PRPF4B | 1.12653501 |
| 52 | PRKCG | 1.09682587 |
| 53 | SIK3 | 1.09547772 |
| 54 | BMPR2 | 1.08982066 |
| 55 | TIE1 | 1.05137001 |
| 56 | KDR | 1.01738217 |
| 57 | MUSK | 1.00092215 |
| 58 | MYLK | 0.98441849 |
| 59 | MAPKAPK3 | 0.98326348 |
| 60 | LIMK1 | 0.98134157 |
| 61 | PDK4 | 0.96682349 |
| 62 | PDK3 | 0.96682349 |
| 63 | BRSK1 | 0.95120271 |
| 64 | OXSR1 | 0.94137144 |
| 65 | NEK2 | 0.92107243 |
| 66 | MAP2K4 | 0.90885463 |
| 67 | RAF1 | 0.88482149 |
| 68 | AURKA | 0.88321476 |
| 69 | CAMK2G | 0.87806971 |
| 70 | CAMK2B | 0.87688632 |
| 71 | BCKDK | 0.85160047 |
| 72 | MARK1 | 0.84981189 |
| 73 | STK39 | 0.84953640 |
| 74 | PLK3 | 0.81859391 |
| 75 | MKNK2 | 0.80878343 |
| 76 | TNIK | 0.78626814 |
| 77 | MST4 | 0.78471096 |
| 78 | SRPK1 | 0.76367018 |
| 79 | CDC7 | 0.76165296 |
| 80 | PAK3 | 0.74331361 |
| 81 | CAMK2A | 0.73072661 |
| 82 | OBSCN | 0.72157887 |
| 83 | TESK1 | 0.72035570 |
| 84 | ABL2 | 0.71829721 |
| 85 | MKNK1 | 0.71350742 |
| 86 | BRSK2 | 0.69530728 |
| 87 | TESK2 | 0.68345937 |
| 88 | RPS6KA5 | 0.67854661 |
| 89 | CDK14 | 0.64943725 |
| 90 | CAMK2D | 0.62370412 |
| 91 | PDK2 | 0.62328297 |
| 92 | VRK1 | 0.62192605 |
| 93 | CDK18 | 0.60017227 |
| 94 | KSR1 | 0.57743500 |
| 95 | TTK | 0.56705533 |
| 96 | CSNK1G2 | 0.54991035 |
| 97 | DYRK3 | 0.54952860 |
| 98 | DAPK3 | 0.53999483 |
| 99 | ZAK | 0.53987305 |
| 100 | MAPK13 | 0.53786300 |
| 101 | CDK8 | 0.53745781 |
| 102 | CSNK1G3 | 0.53647095 |
| 103 | CDK15 | 0.51254307 |
| 104 | EPHA2 | 0.50893959 |
| 105 | TAOK3 | 0.50678187 |
| 106 | PRKCI | 0.50580811 |
| 107 | CSNK1A1 | 0.49222369 |
| 108 | ADRBK2 | 0.48701599 |
| 109 | PLK1 | 0.48517746 |
| 110 | MAPKAPK5 | 0.48216357 |
| 111 | PRKCE | 0.47437747 |
| 112 | MAP2K6 | 0.47226934 |
| 113 | CDK11A | 0.47114350 |
| 114 | AURKB | 0.46272669 |
| 115 | STK38L | 0.45912272 |
| 116 | GRK7 | 0.45892881 |
| 117 | ATR | 0.45628963 |
| 118 | EIF2AK2 | 0.44127455 |
| 119 | STK24 | 0.43239214 |
| 120 | RPS6KA4 | 0.43031641 |
| 121 | PKN1 | 0.39885224 |
| 122 | CDK5 | 0.39275667 |
| 123 | BMPR1B | 0.39150302 |
| 124 | ADRBK1 | 0.38661284 |
| 125 | ILK | 0.38195092 |
| 126 | CSNK2A1 | 0.38095087 |
| 127 | LMTK2 | 0.37083455 |
| 128 | MAP2K1 | 0.36845684 |
| 129 | PHKG2 | 0.36606598 |
| 130 | PHKG1 | 0.36606598 |
| 131 | DYRK2 | 0.36160666 |
| 132 | TNK2 | 0.34896118 |
| 133 | NTRK1 | 0.33742957 |
| 134 | KSR2 | 0.31603046 |
| 135 | CSNK2A2 | 0.30810908 |
| 136 | PRKACA | 0.30279485 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.03864897 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.77118941 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.19712524 |
| 4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.17797090 |
| 5 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 3.09347847 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.07763550 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.03541619 |
| 8 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.97674614 |
| 9 | Ribosome_Homo sapiens_hsa03010 | 2.39076549 |
| 10 | Nicotine addiction_Homo sapiens_hsa05033 | 2.28365312 |
| 11 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.18666004 |
| 12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.11789155 |
| 13 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.04829974 |
| 14 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.97247252 |
| 15 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.90048077 |
| 16 | Protein export_Homo sapiens_hsa03060 | 1.84873093 |
| 17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.83826134 |
| 18 | Olfactory transduction_Homo sapiens_hsa04740 | 1.65297988 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.62594869 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.57338326 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.54199742 |
| 22 | Phototransduction_Homo sapiens_hsa04744 | 1.45955130 |
| 23 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.39315515 |
| 24 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.36332087 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.30689188 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.30475676 |
| 27 | GABAergic synapse_Homo sapiens_hsa04727 | 1.23827307 |
| 28 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.21039437 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.19895530 |
| 30 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.11575916 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.11276508 |
| 32 | RNA transport_Homo sapiens_hsa03013 | 1.10182679 |
| 33 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.09926377 |
| 34 | Taste transduction_Homo sapiens_hsa04742 | 1.09878163 |
| 35 | Long-term potentiation_Homo sapiens_hsa04720 | 1.07127207 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.04440954 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.03162295 |
| 38 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.00230936 |
| 39 | Circadian entrainment_Homo sapiens_hsa04713 | 0.99372310 |
| 40 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.99082691 |
| 41 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.98652705 |
| 42 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.97864175 |
| 43 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.96971947 |
| 44 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.96567554 |
| 45 | Spliceosome_Homo sapiens_hsa03040 | 0.96120914 |
| 46 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.95202481 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.94283273 |
| 48 | Morphine addiction_Homo sapiens_hsa05032 | 0.93690081 |
| 49 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.91839726 |
| 50 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.90604114 |
| 51 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.89045910 |
| 52 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.88951398 |
| 53 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.88834139 |
| 54 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.88784556 |
| 55 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.84985692 |
| 56 | Sulfur relay system_Homo sapiens_hsa04122 | 0.84923730 |
| 57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.84727169 |
| 58 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.84716547 |
| 59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.81003240 |
| 60 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.80892547 |
| 61 | Mismatch repair_Homo sapiens_hsa03430 | 0.80523348 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80064407 |
| 63 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.80022965 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.78983696 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.78517118 |
| 66 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.78415384 |
| 67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.78321089 |
| 68 | DNA replication_Homo sapiens_hsa03030 | 0.78290975 |
| 69 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.76462870 |
| 70 | Basal transcription factors_Homo sapiens_hsa03022 | 0.75946370 |
| 71 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.75286025 |
| 72 | Carbon metabolism_Homo sapiens_hsa01200 | 0.74179657 |
| 73 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.72538404 |
| 74 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71988927 |
| 75 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71219007 |
| 76 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.71187628 |
| 77 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.70318056 |
| 78 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.70243001 |
| 79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.70182056 |
| 80 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.66940872 |
| 81 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.66819494 |
| 82 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.66427158 |
| 83 | Salivary secretion_Homo sapiens_hsa04970 | 0.66354121 |
| 84 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.66233043 |
| 85 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.66218070 |
| 86 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.64130235 |
| 87 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.63576159 |
| 88 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.62203306 |
| 89 | Homologous recombination_Homo sapiens_hsa03440 | 0.61279623 |
| 90 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.60728350 |
| 91 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59769358 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.59708541 |
| 93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.57917434 |
| 94 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.57757857 |
| 95 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57370558 |
| 96 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.54697798 |
| 97 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.53620308 |
| 98 | Phagosome_Homo sapiens_hsa04145 | 0.53544830 |
| 99 | Retinol metabolism_Homo sapiens_hsa00830 | 0.51059915 |
| 100 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48561165 |
| 101 | Insulin secretion_Homo sapiens_hsa04911 | 0.48342198 |
| 102 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45965217 |
| 103 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45442162 |
| 104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44497969 |
| 105 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.42642421 |
| 106 | Long-term depression_Homo sapiens_hsa04730 | 0.40060315 |
| 107 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.37821203 |
| 108 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.37230369 |
| 109 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.36973139 |
| 110 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.36653029 |
| 111 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.36304333 |
| 112 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.35857517 |
| 113 | Base excision repair_Homo sapiens_hsa03410 | 0.34879740 |
| 114 | RNA degradation_Homo sapiens_hsa03018 | 0.34505200 |
| 115 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.34369025 |
| 116 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.34144178 |
| 117 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.31113644 |
| 118 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30857791 |
| 119 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.30850887 |
| 120 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.29682278 |
| 121 | Asthma_Homo sapiens_hsa05310 | 0.25972699 |
| 122 | Galactose metabolism_Homo sapiens_hsa00052 | 0.24636471 |
| 123 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.22947545 |
| 124 | Renin secretion_Homo sapiens_hsa04924 | 0.22666713 |
| 125 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.22205651 |
| 126 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.21469903 |
| 127 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.20946972 |
| 128 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.20061713 |
| 129 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.18840358 |
| 130 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.18295092 |
| 131 | Gap junction_Homo sapiens_hsa04540 | 0.18015177 |
| 132 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.17234387 |
| 133 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.16749671 |
| 134 | Peroxisome_Homo sapiens_hsa04146 | 0.16550098 |
| 135 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.16311694 |
| 136 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.15826171 |
| 137 | Circadian rhythm_Homo sapiens_hsa04710 | 0.15765105 |

