ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.97263895
2	viral transcription (GO:0019083)	5.52359969
3	ribosomal small subunit assembly (GO:0000028)	5.41640598
4	translational termination (GO:0006415)	5.39505027
5	ribosomal small subunit biogenesis (GO:0042274)	5.19341104
6	translational elongation (GO:0006414)	4.79756846
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.79398094
8	cotranslational protein targeting to membrane (GO:0006613)	4.72363867
9	protein targeting to ER (GO:0045047)	4.70563097
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.60155732
11	protein localization to endoplasmic reticulum (GO:0070972)	4.52242325
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.47124902
13	maturation of SSU-rRNA (GO:0030490)	4.46918452
14	translational initiation (GO:0006413)	4.31154700
15	ribosomal large subunit biogenesis (GO:0042273)	4.26773562
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.21638036
17	ATP synthesis coupled proton transport (GO:0015986)	4.21638036
18	viral life cycle (GO:0019058)	4.15553935
19	proteasome assembly (GO:0043248)	4.15133326
20	pyrimidine nucleotide catabolic process (GO:0006244)	4.07912170
21	cellular protein complex disassembly (GO:0043624)	4.07655070
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.03430026
23	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.96435708
24	protein neddylation (GO:0045116)	3.88401639
25	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.84509573
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.84509573
27	translation (GO:0006412)	3.81095596
28	base-excision repair, AP site formation (GO:0006285)	3.79653636
29	glycine metabolic process (GO:0006544)	3.69196817
30	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.68864067
31	L-phenylalanine metabolic process (GO:0006558)	3.68864067
32	ribonucleoprotein complex biogenesis (GO:0022613)	3.68566635
33	respiratory electron transport chain (GO:0022904)	3.64883461
34	serine family amino acid biosynthetic process (GO:0009070)	3.63027899
35	cytochrome complex assembly (GO:0017004)	3.59576630
36	protein maturation by protein folding (GO:0022417)	3.57165073
37	electron transport chain (GO:0022900)	3.55307852
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.53672130
39	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.51602033
40	oxidative phosphorylation (GO:0006119)	3.51227440
41	ATP biosynthetic process (GO:0006754)	3.49796959
42	pseudouridine synthesis (GO:0001522)	3.49176699
43	folic acid metabolic process (GO:0046655)	3.48829288
44	rRNA modification (GO:0000154)	3.48805086
45	protein complex disassembly (GO:0043241)	3.47213587
46	deoxyribonucleotide catabolic process (GO:0009264)	3.45672758
47	pteridine-containing compound biosynthetic process (GO:0042559)	3.45246519
48	telomere maintenance via semi-conservative replication (GO:0032201)	3.44509464
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.42395885
50	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.42385784
51	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.42254041
52	formation of translation preinitiation complex (GO:0001731)	3.42247191
53	DNA strand elongation involved in DNA replication (GO:0006271)	3.42122950
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41551288
55	peptidyl-histidine modification (GO:0018202)	3.40354514
56	regulation of mitochondrial translation (GO:0070129)	3.39499534
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.38165800
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.36630762
59	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.35983689
60	UTP biosynthetic process (GO:0006228)	3.34347398
61	L-methionine salvage (GO:0071267)	3.33225772
62	L-methionine biosynthetic process (GO:0071265)	3.33225772
63	amino acid salvage (GO:0043102)	3.33225772
64	cellular component biogenesis (GO:0044085)	3.32473742
65	mitochondrial transport (GO:0006839)	3.31853317
66	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.30586267
67	macromolecular complex disassembly (GO:0032984)	3.29730810
68	L-serine metabolic process (GO:0006563)	3.29523647
69	CTP biosynthetic process (GO:0006241)	3.27506354
70	CTP metabolic process (GO:0046036)	3.27506354
71	deoxyribose phosphate catabolic process (GO:0046386)	3.26354829
72	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.26231799
73	L-phenylalanine catabolic process (GO:0006559)	3.24853331
74	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.24853331
75	serine family amino acid metabolic process (GO:0009069)	3.22078121
76	establishment of integrated proviral latency (GO:0075713)	3.20865801
77	DNA strand elongation (GO:0022616)	3.20728977
78	cysteine metabolic process (GO:0006534)	3.19201319
79	folic acid-containing compound biosynthetic process (GO:0009396)	3.15753240
80	protein targeting to mitochondrion (GO:0006626)	3.14693689
81	guanosine-containing compound biosynthetic process (GO:1901070)	3.13753221
82	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.12835247
83	iron-sulfur cluster assembly (GO:0016226)	3.12582418
84	metallo-sulfur cluster assembly (GO:0031163)	3.12582418
85	hydrogen ion transmembrane transport (GO:1902600)	3.11638420
86	protein targeting to membrane (GO:0006612)	3.10117178
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09662484
88	establishment of protein localization to mitochondrion (GO:0072655)	3.08454744
89	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.08302702
90	termination of RNA polymerase III transcription (GO:0006386)	3.08302702
91	nucleoside triphosphate biosynthetic process (GO:0009142)	3.08176331
92	DNA replication initiation (GO:0006270)	3.07981698
93	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.06822341
94	protein deneddylation (GO:0000338)	3.06489240
95	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.05303215
96	cullin deneddylation (GO:0010388)	3.04418902
97	rRNA processing (GO:0006364)	3.04326782
98	DNA damage response, detection of DNA damage (GO:0042769)	3.03714234
99	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.03626280
100	NADH dehydrogenase complex assembly (GO:0010257)	3.03626280
101	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.03626280
102	UTP metabolic process (GO:0046051)	3.03274227
103	intracellular protein transmembrane import (GO:0044743)	3.03151188
104	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.02864146
105	glyoxylate metabolic process (GO:0046487)	3.02675615
106	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.02007542
107	nucleobase biosynthetic process (GO:0046112)	3.00070883
108	purine nucleobase biosynthetic process (GO:0009113)	2.99011591
109	heme biosynthetic process (GO:0006783)	2.96074225
110	regulation of cellular amino acid metabolic process (GO:0006521)	2.94645891
111	ribosome biogenesis (GO:0042254)	2.94488507
112	aldehyde catabolic process (GO:0046185)	2.93738884
113	rRNA metabolic process (GO:0016072)	2.92382314
114	ubiquinone biosynthetic process (GO:0006744)	2.91610810
115	quinone biosynthetic process (GO:1901663)	2.91610810
116	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.91596204
117	spliceosomal snRNP assembly (GO:0000387)	2.91452575
118	protein localization to mitochondrion (GO:0070585)	2.87752235
119	nucleobase-containing small molecule interconversion (GO:0015949)	2.87284613
120	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85377355
121	protein complex biogenesis (GO:0070271)	2.82601399
122	ribosome assembly (GO:0042255)	2.81489968
123	sulfur amino acid biosynthetic process (GO:0000097)	2.80795445
124	respiratory chain complex IV assembly (GO:0008535)	2.78852643
125	telomere maintenance via recombination (GO:0000722)	2.78813663
126	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77903705
127	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.77540375
128	negative regulation of ligase activity (GO:0051352)	2.77540375
129	chaperone-mediated protein transport (GO:0072321)	2.74437155
130	mRNA catabolic process (GO:0006402)	2.73947033
131	pteridine-containing compound metabolic process (GO:0042558)	2.73894683
132	aromatic amino acid family catabolic process (GO:0009074)	2.72147132
133	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.72140576
134	methionine metabolic process (GO:0006555)	2.72090978
135	nucleoside salvage (GO:0043174)	2.68985236
136	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68366782
137	serine family amino acid catabolic process (GO:0009071)	2.67582493
138	GTP biosynthetic process (GO:0006183)	2.66695253

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.33400324
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.25557262
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.75437242
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55519796
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.36902858
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.35315334
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.32505157
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.28728942
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.11029161
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.09915680
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.00740112
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.93014750
13	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.86017064
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.83043085
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.66040941
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.63970977
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.61632796
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.35434964
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34495668
20	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.27144553
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.25874330
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.25272067
23	VDR_23849224_ChIP-Seq_CD4+_Human	2.20148617
24	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.19870336
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.19544992
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07590879
27	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.02983542
28	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.98245758
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.95070904
30	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.94155042
31	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.89802637
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89412051
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.88915323
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.87255702
35	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.85033416
36	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.82436385
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.80383820
38	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.78615854
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.75416974
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.73834667
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.72334663
42	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.67277505
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.65982897
44	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.59821476
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.59708668
46	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.59457145
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57215722
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56308238
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53970054
50	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.51744264
51	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.49778795
52	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.48514308
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.47684528
54	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.45378987
55	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.44869991
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43321099
57	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40058500
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.39781137
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38942303
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36980935
61	AR_21909140_ChIP-Seq_LNCAP_Human	1.33700639
62	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.31235202
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29115341
64	ZNF263_19887448_ChIP-Seq_K562_Human	1.28374129
65	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.25681358
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.24503698
67	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.22847127
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.19802053
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19759361
70	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.18267182
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.16068826
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15704158
73	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.14444669
74	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.12251887
75	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.11849287
76	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.11277731
77	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.11264100
78	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.08786103
79	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.05772714
80	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.05377819
81	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.03964422
82	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.03109241
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02750615
84	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.02649052
85	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.01986210
86	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01943104
87	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01552893
88	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.00955097
89	CIITA_25753668_ChIP-Seq_RAJI_Human	1.00816943
90	MYC_18940864_ChIP-ChIP_HL60_Human	0.99534611
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98139389
92	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.98065489
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96904788
94	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.96664193
95	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.94566202
96	VDR_21846776_ChIP-Seq_THP-1_Human	0.93375486
97	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.92450632
98	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.92372147
99	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.89935701
100	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.89621473
101	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.88218479
102	SPI1_23547873_ChIP-Seq_NB4_Human	0.87587056
103	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.87534667
104	BCL6_27268052_Chip-Seq_Bcells_Human	0.87313661
105	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.85692060
106	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.85427194
107	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.85381391
108	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.85332400
109	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.85251747
110	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.83893018
111	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.83286876
112	MYC_22102868_ChIP-Seq_BL_Human	0.83236520
113	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.83184478
114	TFEB_21752829_ChIP-Seq_HELA_Human	0.82808248
115	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82548944
116	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.81815324
117	P68_20966046_ChIP-Seq_HELA_Human	0.81648899
118	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.81237809
119	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.79443826

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.07176845
2	MP0002139_abnormal_hepatobiliary_system	4.86231826
3	MP0005360_urolithiasis	4.26362371
4	MP0009379_abnormal_foot_pigmentation	3.67661399
5	MP0005085_abnormal_gallbladder_physiolo	3.54521890
6	MP0005365_abnormal_bile_salt	3.41225364
7	MP0006292_abnormal_olfactory_placode	3.34106533
8	MP0003693_abnormal_embryo_hatching	3.33952936
9	MP0003186_abnormal_redox_activity	3.04973261
10	MP0008789_abnormal_olfactory_epithelium	2.88078163
11	MP0006036_abnormal_mitochondrial_physio	2.87491513
12	MP0004957_abnormal_blastocyst_morpholog	2.80579820
13	MP0010030_abnormal_orbit_morphology	2.80016048
14	MP0008875_abnormal_xenobiotic_pharmacok	2.62048948
15	MP0005083_abnormal_biliary_tract	2.55382941
16	MP0002163_abnormal_gland_morphology	2.41917324
17	MP0009840_abnormal_foam_cell	2.38508522
18	MP0005332_abnormal_amino_acid	2.38432204
19	MP0005499_abnormal_olfactory_system	2.28880986
20	MP0005394_taste/olfaction_phenotype	2.28880986
21	MP0003656_abnormal_erythrocyte_physiolo	2.10566668
22	MP0006035_abnormal_mitochondrial_morpho	2.09955006
23	MP0002653_abnormal_ependyma_morphology	2.02277970
24	MP0003646_muscle_fatigue	1.94530305
25	MP0001764_abnormal_homeostasis	1.81302717
26	MP0003195_calcinosis	1.79016332
27	MP0002102_abnormal_ear_morphology	1.76632135
28	MP0000049_abnormal_middle_ear	1.73289581
29	MP0005319_abnormal_enzyme/_coenzyme	1.72597871
30	MP0001666_abnormal_nutrient_absorption	1.71906578
31	MP0010329_abnormal_lipoprotein_level	1.70575412
32	MP0001293_anophthalmia	1.69468747
33	MP0010094_abnormal_chromosome_stability	1.69259246
34	MP0003718_maternal_effect	1.69007338
35	MP0003077_abnormal_cell_cycle	1.65651073
36	MP0002160_abnormal_reproductive_system	1.59107859
37	MP0002837_dystrophic_cardiac_calcinosis	1.58633920
38	MP0008932_abnormal_embryonic_tissue	1.57522606
39	MP0003111_abnormal_nucleus_morphology	1.55756423
40	MP0005584_abnormal_enzyme/coenzyme_acti	1.52594466
41	MP0003315_abnormal_perineum_morphology	1.49329495
42	MP0002132_abnormal_respiratory_system	1.49292463
43	MP0002736_abnormal_nociception_after	1.48510024
44	MP0004147_increased_porphyrin_level	1.43927923
45	MP0000609_abnormal_liver_physiology	1.42654059
46	MP0005266_abnormal_metabolism	1.42177434
47	MP0003136_yellow_coat_color	1.39168218
48	MP0005636_abnormal_mineral_homeostasis	1.38519943
49	MP0001853_heart_inflammation	1.37145946
50	MP0003221_abnormal_cardiomyocyte_apopto	1.35389275
51	MP0003191_abnormal_cellular_cholesterol	1.35095241
52	MP0001905_abnormal_dopamine_level	1.33259315
53	MP0009333_abnormal_splenocyte_physiolog	1.33216895
54	MP0000372_irregular_coat_pigmentation	1.32615506
55	MP0005646_abnormal_pituitary_gland	1.31726167
56	MP0005379_endocrine/exocrine_gland_phen	1.30962914
57	MP0009643_abnormal_urine_homeostasis	1.29395108
58	MP0000358_abnormal_cell_content/	1.27785475
59	MP0002234_abnormal_pharynx_morphology	1.27225906
60	MP0000490_abnormal_crypts_of	1.25300899
61	MP0005451_abnormal_body_composition	1.23473329
62	MP0009697_abnormal_copulation	1.22820670
63	MP0002210_abnormal_sex_determination	1.21976169
64	MP0005075_abnormal_melanosome_morpholog	1.20968324
65	MP0005389_reproductive_system_phenotype	1.15220013
66	MP0004133_heterotaxia	1.14314753
67	MP0008058_abnormal_DNA_repair	1.14260121
68	MP0003724_increased_susceptibility_to	1.14000292
69	MP0003252_abnormal_bile_duct	1.12394437
70	MP0002118_abnormal_lipid_homeostasis	1.11646071
71	MP0004019_abnormal_vitamin_homeostasis	1.10738811
72	MP0002396_abnormal_hematopoietic_system	1.10162983
73	MP0006276_abnormal_autonomic_nervous	1.10031204
74	MP0008469_abnormal_protein_level	1.09896366
75	MP0005084_abnormal_gallbladder_morpholo	1.09770082
76	MP0000598_abnormal_liver_morphology	1.09168621
77	MP0005376_homeostasis/metabolism_phenot	1.08494479
78	MP0002938_white_spotting	1.06529363
79	MP0001188_hyperpigmentation	1.05893187
80	MP0004145_abnormal_muscle_electrophysio	1.05798257
81	MP0005330_cardiomyopathy	1.02394957
82	MP0003786_premature_aging	1.02067068
83	MP0001727_abnormal_embryo_implantation	1.01530302
84	MP0001919_abnormal_reproductive_system	1.00589189
85	MP0000678_abnormal_parathyroid_gland	0.99731843
86	MP0001730_embryonic_growth_arrest	0.99134834
87	MP0003567_abnormal_fetal_cardiomyocyte	0.97830860
88	MP0009053_abnormal_anal_canal	0.96746313
89	MP0002138_abnormal_hepatobiliary_system	0.95996396
90	MP0008007_abnormal_cellular_replicative	0.95236575
91	MP0001542_abnormal_bone_strength	0.94528065
92	MP0001968_abnormal_touch/_nociception	0.94162632
93	MP0003011_delayed_dark_adaptation	0.93238618
94	MP0003763_abnormal_thymus_physiology	0.92971845
95	MP0002249_abnormal_larynx_morphology	0.92750940
96	MP0000751_myopathy	0.91970852
97	MP0008057_abnormal_DNA_replication	0.91536753
98	MP0001145_abnormal_male_reproductive	0.91280727
99	MP0006072_abnormal_retinal_apoptosis	0.90655859
100	MP0002019_abnormal_tumor_incidence	0.89288918
101	MP0002233_abnormal_nose_morphology	0.88839290
102	MP0003121_genomic_imprinting	0.86461978
103	MP0000653_abnormal_sex_gland	0.84727874
104	MP0009763_increased_sensitivity_to	0.83706929
105	MP0001929_abnormal_gametogenesis	0.83454926
106	MP0003137_abnormal_impulse_conducting	0.81389612
107	MP0004233_abnormal_muscle_weight	0.81129112
108	MP0003868_abnormal_feces_composition	0.80832835
109	MP0000689_abnormal_spleen_morphology	0.80758473
110	MP0001485_abnormal_pinna_reflex	0.79525150
111	MP0005670_abnormal_white_adipose	0.78933273
112	MP0009785_altered_susceptibility_to	0.77854359
113	MP0002277_abnormal_respiratory_mucosa	0.76670267
114	MP0001545_abnormal_hematopoietic_system	0.75278062
115	MP0005397_hematopoietic_system_phenotyp	0.75278062
116	MP0000313_abnormal_cell_death	0.74908224
117	MP0002638_abnormal_pupillary_reflex	0.74596436
118	MP0002095_abnormal_skin_pigmentation	0.74345973
119	MP0008873_increased_physiological_sensi	0.74082095
120	MP0000750_abnormal_muscle_regeneration	0.73517173
121	MP0003436_decreased_susceptibility_to	0.73336036
122	MP0002722_abnormal_immune_system	0.72577127
123	MP0002080_prenatal_lethality	0.71726332
124	MP0002269_muscular_atrophy	0.71216410
125	MP0005220_abnormal_exocrine_pancreas	0.71216010
126	MP0000749_muscle_degeneration	0.69218411
127	MP0001529_abnormal_vocalization	0.68732565
128	MP0004142_abnormal_muscle_tone	0.68184218
129	MP0001346_abnormal_lacrimal_gland	0.67862337
130	MP0002332_abnormal_exercise_endurance	0.67222172
131	MP0003942_abnormal_urinary_system	0.66942134
132	MP0009642_abnormal_blood_homeostasis	0.66543327
133	MP0000631_abnormal_neuroendocrine_gland	0.66422955
134	MP0000747_muscle_weakness	0.66154802
135	MP0005025_abnormal_response_to	0.65810626
136	MP0002697_abnormal_eye_size	0.65510380
137	MP0005195_abnormal_posterior_eye	0.64412041
138	MP0005666_abnormal_adipose_tissue	0.64139436
139	MP0000350_abnormal_cell_proliferation	0.63994736
140	MP0002752_abnormal_somatic_nervous	0.62964882
141	MP0002429_abnormal_blood_cell	0.62382571
142	MP0001119_abnormal_female_reproductive	0.62349570
143	MP0001286_abnormal_eye_development	0.62127435
144	MP0000685_abnormal_immune_system	0.60940766
145	MP0003123_paternal_imprinting	0.60762898
146	MP0003937_abnormal_limbs/digits/tail_de	0.60229901
147	MP0003755_abnormal_palate_morphology	0.59981426
148	MP0001697_abnormal_embryo_size	0.59941192
149	MP0001873_stomach_inflammation	0.59897965
150	MP0005408_hypopigmentation	0.59446860
151	MP0005377_hearing/vestibular/ear_phenot	0.59376573
152	MP0003878_abnormal_ear_physiology	0.59376573
153	MP0006054_spinal_hemorrhage	0.59337011
154	MP0004782_abnormal_surfactant_physiolog	0.59331935
155	MP0002971_abnormal_brown_adipose	0.59202278
156	MP0003638_abnormal_response/metabolism_	0.58848369
157	MP0003938_abnormal_ear_development	0.58558186
158	MP0002398_abnormal_bone_marrow	0.56495407
159	MP0000343_altered_response_to	0.56108659
160	MP0001663_abnormal_digestive_system	0.55868356

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.02567576
2	Abnormal number of erythroid precursors (HP:0012131)	4.85167349
3	Hepatic necrosis (HP:0002605)	4.52690357
4	Hepatocellular necrosis (HP:0001404)	4.48264224
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.28766713
6	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.23580086
7	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.23580086
8	Acute necrotizing encephalopathy (HP:0006965)	4.18418738
9	Mitochondrial inheritance (HP:0001427)	4.11837703
10	Abnormal mitochondria in muscle tissue (HP:0008316)	4.06260102
11	Acute encephalopathy (HP:0006846)	4.05064500
12	Reticulocytopenia (HP:0001896)	4.00100648
13	Lipid accumulation in hepatocytes (HP:0006561)	3.89664758
14	Increased CSF lactate (HP:0002490)	3.85758518
15	Increased intramyocellular lipid droplets (HP:0012240)	3.80096230
16	Increased muscle lipid content (HP:0009058)	3.79830120
17	Macrocytic anemia (HP:0001972)	3.77217310
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.76872336
19	Cerebral edema (HP:0002181)	3.74977703
20	Increased hepatocellular lipid droplets (HP:0006565)	3.73637935
21	Increased serum lactate (HP:0002151)	3.51553804
22	Lactic acidosis (HP:0003128)	3.36133305
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.31839575
24	Progressive macrocephaly (HP:0004481)	3.25095023
25	Hypobetalipoproteinemia (HP:0003563)	3.22937299
26	Lethargy (HP:0001254)	3.08700883
27	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.06275940
28	Abnormality of glycolysis (HP:0004366)	3.05867097
29	Increased serum pyruvate (HP:0003542)	3.05867097
30	Dicarboxylic aciduria (HP:0003215)	3.04360870
31	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.04360870
32	3-Methylglutaconic aciduria (HP:0003535)	3.00428756
33	Multiple enchondromatosis (HP:0005701)	2.99729305
34	Renal Fanconi syndrome (HP:0001994)	2.96772941
35	Hyperammonemia (HP:0001987)	2.96463145
36	Pallor (HP:0000980)	2.94291615
37	Intrahepatic cholestasis (HP:0001406)	2.93466820
38	Abnormality of fatty-acid metabolism (HP:0004359)	2.92658174
39	Respiratory failure (HP:0002878)	2.91311677
40	Hyperglycinuria (HP:0003108)	2.88253135
41	Oral leukoplakia (HP:0002745)	2.87177772
42	Exercise intolerance (HP:0003546)	2.83336189
43	Exertional dyspnea (HP:0002875)	2.82836422
44	Progressive muscle weakness (HP:0003323)	2.78108849
45	Abnormality of glycine metabolism (HP:0010895)	2.76646533
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.76646533
47	CNS demyelination (HP:0007305)	2.75267368
48	Hyperglycinemia (HP:0002154)	2.74961249
49	Optic disc pallor (HP:0000543)	2.73465984
50	Xanthomatosis (HP:0000991)	2.66504661
51	Nausea (HP:0002018)	2.65169703
52	Abnormality of serum amino acid levels (HP:0003112)	2.63918444
53	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.61702672
54	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.56992481
55	Aplastic anemia (HP:0001915)	2.56692940
56	Prolonged partial thromboplastin time (HP:0003645)	2.55839464
57	Delayed CNS myelination (HP:0002188)	2.55235254
58	Hypoglycemic coma (HP:0001325)	2.55108393
59	Ragged-red muscle fibers (HP:0003200)	2.52994969
60	Type I transferrin isoform profile (HP:0003642)	2.48533142
61	Abnormality of urine glucose concentration (HP:0011016)	2.48053185
62	Glycosuria (HP:0003076)	2.48053185
63	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.47538626
64	Ketosis (HP:0001946)	2.45484489
65	Generalized aminoaciduria (HP:0002909)	2.44461360
66	Microretrognathia (HP:0000308)	2.44409584
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39469712
68	Abnormality of alanine metabolism (HP:0010916)	2.39469712
69	Hyperalaninemia (HP:0003348)	2.39469712
70	Respiratory difficulties (HP:0002880)	2.37965351
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.35124255
72	Abnormality of methionine metabolism (HP:0010901)	2.34035662
73	Rhabdomyolysis (HP:0003201)	2.33455157
74	Hyperlipoproteinemia (HP:0010980)	2.32893791
75	Microvesicular hepatic steatosis (HP:0001414)	2.32629155
76	Abnormality of pyrimidine metabolism (HP:0004353)	2.26893388
77	Hyperphosphaturia (HP:0003109)	2.25195662
78	Sclerocornea (HP:0000647)	2.25065677
79	Brushfield spots (HP:0001088)	2.21411940
80	Vomiting (HP:0002013)	2.21147308
81	Reduced antithrombin III activity (HP:0001976)	2.21130256
82	Hypolipoproteinemia (HP:0010981)	2.19159340
83	Emotional lability (HP:0000712)	2.18155978
84	Testicular atrophy (HP:0000029)	2.17275566
85	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.17166196
86	Abnormal protein N-linked glycosylation (HP:0012347)	2.17166196
87	Abnormal protein glycosylation (HP:0012346)	2.17166196
88	Abnormal glycosylation (HP:0012345)	2.17166196
89	Deep venous thrombosis (HP:0002625)	2.17136738
90	X-linked dominant inheritance (HP:0001423)	2.16498829
91	Megaloblastic anemia (HP:0001889)	2.16379554
92	Abnormal hemoglobin (HP:0011902)	2.14205148
93	Abnormality of renal resorption (HP:0011038)	2.12779932
94	Absent thumb (HP:0009777)	2.11797510
95	Hyperbilirubinemia (HP:0002904)	2.08083961
96	Metabolic acidosis (HP:0001942)	2.07486859
97	Myoglobinuria (HP:0002913)	2.07209225
98	Pancytopenia (HP:0001876)	2.05460643
99	Cerebral hypomyelination (HP:0006808)	2.03766359
100	Rough bone trabeculation (HP:0100670)	2.03360790
101	Abnormality of reticulocytes (HP:0004312)	2.02500906
102	Colon cancer (HP:0003003)	2.02374935
103	Spastic paraparesis (HP:0002313)	1.99611196
104	Proximal tubulopathy (HP:0000114)	1.99350108
105	Leukodystrophy (HP:0002415)	1.99007890
106	Increased serum ferritin (HP:0003281)	1.96761054
107	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.96586996
108	Methylmalonic aciduria (HP:0012120)	1.96363146
109	Adrenal hypoplasia (HP:0000835)	1.94078536
110	Cleft eyelid (HP:0000625)	1.93141137
111	Abnormality of midbrain morphology (HP:0002418)	1.92530548
112	Molar tooth sign on MRI (HP:0002419)	1.92530548
113	Gout (HP:0001997)	1.89734109
114	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.88259516
115	Rib fusion (HP:0000902)	1.87943345
116	Abnormal cartilage morphology (HP:0002763)	1.86933302
117	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.86659423
118	Breast hypoplasia (HP:0003187)	1.86624018
119	Trismus (HP:0000211)	1.86338240
120	Muscle fiber atrophy (HP:0100295)	1.85868536
121	Pancreatic fibrosis (HP:0100732)	1.79058801
122	Abnormality of the anterior horn cell (HP:0006802)	1.77028571
123	Degeneration of anterior horn cells (HP:0002398)	1.77028571
124	Progressive microcephaly (HP:0000253)	1.76874314
125	Septo-optic dysplasia (HP:0100842)	1.73668619
126	Blindness (HP:0000618)	1.73252623
127	Double outlet right ventricle (HP:0001719)	1.72307710
128	Congenital malformation of the right heart (HP:0011723)	1.72307710
129	Medial flaring of the eyebrow (HP:0010747)	1.70445470
130	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.67562962
131	Stenosis of the external auditory canal (HP:0000402)	1.67263234
132	Horseshoe kidney (HP:0000085)	1.66710531
133	Opisthotonus (HP:0002179)	1.65759741
134	Poor suck (HP:0002033)	1.65703698
135	Gliosis (HP:0002171)	1.64462476
136	Abnormal number of incisors (HP:0011064)	1.63463043
137	Myokymia (HP:0002411)	1.63132186
138	Hypoplasia of the radius (HP:0002984)	1.63110336
139	Sparse eyelashes (HP:0000653)	1.60171686
140	Hypoplastic left heart (HP:0004383)	1.56635037

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.00962559
2	NME2	4.77417891
3	EIF2AK1	4.53980958
4	BCKDK	3.95125764
5	STK16	3.84539448
6	WEE1	3.53942651
7	BUB1	3.38101830
8	TESK2	3.15066162
9	PIM2	2.60556596
10	MAP3K11	2.49946938
11	KDR	2.37743834
12	TLK1	2.33538222
13	EIF2AK3	2.33368495
14	DYRK3	2.29799100
15	PDK2	2.13609093
16	NME1	1.98463105
17	ACVR1B	1.96978048
18	MAP2K7	1.92382499
19	SRPK1	1.79032033
20	VRK1	1.75802804
21	SCYL2	1.56406994
22	ZAK	1.41135879
23	ARAF	1.40772876
24	ABL2	1.37704845
25	CDK19	1.34121485
26	FLT3	1.33406946
27	NUAK1	1.31600292
28	CSNK1G2	1.22858315
29	MAP4K1	1.19138513
30	BRSK2	1.14841509
31	MAPKAPK3	1.13997256
32	CSNK1A1L	1.13977282
33	BRSK1	1.11113941
34	AURKA	1.08527527
35	CSNK1G1	1.08435509
36	NEK9	1.08430141
37	RPS6KA4	1.07472884
38	BRAF	1.06004522
39	ERN1	1.05928869
40	TESK1	1.03487546
41	TTK	1.02938162
42	MAP2K3	1.00195029
43	LIMK1	0.99632776
44	PLK4	0.98398171
45	MAP3K8	0.97813636
46	PLK1	0.95003527
47	WNK4	0.94740400
48	PBK	0.91174950
49	CDK7	0.90912759
50	TRIM28	0.90679633
51	LRRK2	0.90010122
52	NEK1	0.89161701
53	AURKB	0.88608564
54	MAP4K2	0.88228073
55	TAF1	0.87215577
56	RPS6KB2	0.85829472
57	PINK1	0.85786926
58	PLK3	0.83876336
59	PAK4	0.83849504
60	CDC7	0.82569872
61	CDK8	0.81345454
62	MAP3K12	0.78543800
63	NEK2	0.76718383
64	DYRK1B	0.72627127
65	DYRK2	0.72533129
66	GRK6	0.72000643
67	TEC	0.68561246
68	CSNK2A2	0.68017294
69	BMPR1B	0.67920177
70	GRK1	0.67594703
71	PIM1	0.67188196
72	IRAK3	0.66434014
73	CSNK2A1	0.66195863
74	TGFBR1	0.65558372
75	MAP3K3	0.65278029
76	TBK1	0.64887433
77	PKN2	0.64817469
78	WNK3	0.64450574
79	TAOK2	0.61573078
80	ILK	0.58507967
81	BLK	0.57964424
82	CDK4	0.57941546
83	RAF1	0.56990213
84	MAPK11	0.56601388
85	MAP2K6	0.56259013
86	MYLK	0.54337649
87	MAP3K4	0.54203143
88	RPS6KA5	0.53753579
89	OBSCN	0.53320957
90	MAPK4	0.52343629
91	CDK14	0.52315301
92	MAP2K2	0.51749156
93	PAK1	0.50923504
94	DAPK3	0.50605471
95	ZAP70	0.47886622
96	CHEK1	0.47039475
97	CDK11A	0.46748783
98	TYK2	0.46150931
99	PRKCG	0.45105876
100	EPHB2	0.44916909
101	ADRBK2	0.44587140
102	MKNK1	0.43001705
103	PRKCI	0.42407183
104	CHEK2	0.42367918
105	MAP3K5	0.40936182
106	MST4	0.40890243
107	CAMK2D	0.40748421
108	SMG1	0.40556523
109	PIK3CG	0.40397929
110	BTK	0.40305999
111	EPHA2	0.39823448
112	EIF2AK2	0.39394195
113	CSNK1G3	0.38704850
114	CDK15	0.38083487
115	MKNK2	0.37691440
116	CDK18	0.36408276
117	TIE1	0.36071769
118	AKT2	0.34931618
119	CSNK1A1	0.33444470
120	PDK3	0.33432345
121	PDK4	0.33432345
122	ATR	0.33134835
123	CAMK2G	0.33055651
124	DAPK1	0.32696733
125	MUSK	0.32687582
126	GRK5	0.32677367
127	PHKG2	0.31554394
128	PHKG1	0.31554394
129	CCNB1	0.31461721
130	IRAK4	0.31310889
131	STK10	0.31237347
132	MINK1	0.29931815
133	CSNK1E	0.27145856
134	STK4	0.26589381
135	STK39	0.24965518
136	CDK2	0.23770416
137	CDK1	0.22870626
138	ATM	0.22560582
139	IKBKB	0.22545717
140	BCR	0.22400190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.24924874
2	Proteasome_Homo sapiens_hsa03050	3.00021103
3	DNA replication_Homo sapiens_hsa03030	2.96652062
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.54998356
5	RNA polymerase_Homo sapiens_hsa03020	2.46680026
6	Parkinsons disease_Homo sapiens_hsa05012	2.39675996
7	Mismatch repair_Homo sapiens_hsa03430	2.22967276
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.15910379
9	Folate biosynthesis_Homo sapiens_hsa00790	2.15231728
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.13556119
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03551679
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.01797112
13	Sulfur relay system_Homo sapiens_hsa04122	2.01401485
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.89944294
15	One carbon pool by folate_Homo sapiens_hsa00670	1.84458343
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.81721494
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71722878
18	Huntingtons disease_Homo sapiens_hsa05016	1.70406885
19	Propanoate metabolism_Homo sapiens_hsa00640	1.67204426
20	Protein export_Homo sapiens_hsa03060	1.66176934
21	Spliceosome_Homo sapiens_hsa03040	1.65946893
22	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.64484400
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63917776
24	Fatty acid degradation_Homo sapiens_hsa00071	1.61684276
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58780691
26	Homologous recombination_Homo sapiens_hsa03440	1.58540280
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.56944532
28	Base excision repair_Homo sapiens_hsa03410	1.52504617
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.51479960
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.49443481
31	Alzheimers disease_Homo sapiens_hsa05010	1.48243792
32	Carbon metabolism_Homo sapiens_hsa01200	1.47785218
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.47438727
34	Peroxisome_Homo sapiens_hsa04146	1.47346944
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.45741374
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41603633
37	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.40424406
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.33935835
39	Pentose phosphate pathway_Homo sapiens_hsa00030	1.32763578
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.31913702
41	RNA transport_Homo sapiens_hsa03013	1.26519697
42	Glutathione metabolism_Homo sapiens_hsa00480	1.23990367
43	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18047858
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.16841862
45	Tryptophan metabolism_Homo sapiens_hsa00380	1.16531241
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13546617
47	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.12687607
48	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10351854
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.08959418
50	Fatty acid elongation_Homo sapiens_hsa00062	1.06273395
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.04552641
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.03286139
53	Arginine biosynthesis_Homo sapiens_hsa00220	1.02212372
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.98915539
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.98242681
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96916883
57	Butanoate metabolism_Homo sapiens_hsa00650	0.96896587
58	Purine metabolism_Homo sapiens_hsa00230	0.96888728
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94453870
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92309948
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.92166108
62	Histidine metabolism_Homo sapiens_hsa00340	0.91434103
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90901670
64	Metabolic pathways_Homo sapiens_hsa01100	0.89194533
65	Sulfur metabolism_Homo sapiens_hsa00920	0.87500509
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86451455
67	Caffeine metabolism_Homo sapiens_hsa00232	0.84620802
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82295302
69	Phenylalanine metabolism_Homo sapiens_hsa00360	0.80193238
70	Basal transcription factors_Homo sapiens_hsa03022	0.78017742
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.74676055
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.74118226
73	Complement and coagulation cascades_Homo sapiens_hsa04610	0.72100919
74	PPAR signaling pathway_Homo sapiens_hsa03320	0.71951426
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69770469
76	Retinol metabolism_Homo sapiens_hsa00830	0.69191062
77	Cell cycle_Homo sapiens_hsa04110	0.65472436
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.64936242
79	RNA degradation_Homo sapiens_hsa03018	0.64127081
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62288945
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62128800
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57555727
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55852516
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55804552
85	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50857100
86	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50179363
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49571482
88	Galactose metabolism_Homo sapiens_hsa00052	0.47379772
89	p53 signaling pathway_Homo sapiens_hsa04115	0.46748280
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42778768
91	Regulation of autophagy_Homo sapiens_hsa04140	0.42749938
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.37790565
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.37320477
94	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37217152
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.36795958
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36666872
97	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28578702
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.28505714
99	Phototransduction_Homo sapiens_hsa04744	0.28231099
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27626489
101	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27366392
102	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26768946
103	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26698942
104	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25752884
105	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25505192
106	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.24760992
107	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23740467
108	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.22151391
109	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.21161784
110	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.19507506
111	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.18125436
112	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.17132378
113	Oocyte meiosis_Homo sapiens_hsa04114	0.14425804
114	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.12064549
115	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.10671562

EMC6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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