EMC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.35906840
2central nervous system myelination (GO:0022010)5.09514190
3axon ensheathment in central nervous system (GO:0032291)5.09514190
4protein maturation by protein folding (GO:0022417)4.98594657
5proteasome assembly (GO:0043248)4.61370356
6fatty acid elongation (GO:0030497)4.56558998
7COPI coating of Golgi vesicle (GO:0048205)4.27670361
8Golgi transport vesicle coating (GO:0048200)4.27670361
9protein deneddylation (GO:0000338)4.09431065
10regulation of mitochondrial translation (GO:0070129)3.85285660
11cullin deneddylation (GO:0010388)3.76711605
12regulation of cellular amino acid metabolic process (GO:0006521)3.62517613
13neuronal action potential propagation (GO:0019227)3.55862585
14protein complex biogenesis (GO:0070271)3.52682041
15lipopolysaccharide biosynthetic process (GO:0009103)3.48551407
16NADH metabolic process (GO:0006734)3.37886900
17long-chain fatty acid biosynthetic process (GO:0042759)3.31551652
18negative regulation of neurotransmitter secretion (GO:0046929)3.29893424
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.29287617
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25512477
21nuclear envelope reassembly (GO:0031468)3.25498148
22mitotic nuclear envelope reassembly (GO:0007084)3.25498148
23L-phenylalanine catabolic process (GO:0006559)3.24881660
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24881660
25negative regulation of neurotransmitter transport (GO:0051589)3.23366813
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23188830
27gamma-aminobutyric acid transport (GO:0015812)3.21128183
282-deoxyribonucleotide biosynthetic process (GO:0009265)3.20554959
29deoxyribose phosphate biosynthetic process (GO:0046385)3.20554959
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19295751
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18959279
32protein targeting to mitochondrion (GO:0006626)3.18953470
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16086613
34mannosylation (GO:0097502)3.15125167
35synaptic vesicle exocytosis (GO:0016079)3.13508213
36protein retention in ER lumen (GO:0006621)3.13132939
37mitochondrial respiratory chain complex assembly (GO:0033108)3.12309269
38hydrogen ion transmembrane transport (GO:1902600)3.11091406
39positive regulation of TOR signaling (GO:0032008)3.10784982
40platelet dense granule organization (GO:0060155)3.08785275
41positive regulation of mitochondrial fission (GO:0090141)3.06632437
42antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.05212039
43oxidative phosphorylation (GO:0006119)3.04285954
44myelination (GO:0042552)3.03622248
45establishment of protein localization to mitochondrion (GO:0072655)3.02839744
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02122574
47negative regulation of ligase activity (GO:0051352)3.02122574
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01867904
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01381908
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.99828050
51NADH dehydrogenase complex assembly (GO:0010257)2.99828050
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99828050
53ensheathment of neurons (GO:0007272)2.99740135
54axon ensheathment (GO:0008366)2.99740135
55neuron cell-cell adhesion (GO:0007158)2.98096812
56response to methylmercury (GO:0051597)2.97156029
57protein localization to mitochondrion (GO:0070585)2.96873891
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90563944
59L-phenylalanine metabolic process (GO:0006558)2.90563944
60lipopolysaccharide metabolic process (GO:0008653)2.89231708
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88751625
62gamma-aminobutyric acid signaling pathway (GO:0007214)2.88281051
63long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.87262303
64glutamate secretion (GO:0014047)2.87120510
65regulation of cellular amine metabolic process (GO:0033238)2.85372201
66C-terminal protein lipidation (GO:0006501)2.81668960
67chaperone-mediated protein transport (GO:0072321)2.81310021
68cytochrome complex assembly (GO:0017004)2.79707092
69metallo-sulfur cluster assembly (GO:0031163)2.79055873
70iron-sulfur cluster assembly (GO:0016226)2.79055873
71regulation of synaptic vesicle exocytosis (GO:2000300)2.78983374
72proton transport (GO:0015992)2.78557077
73regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77658821
74positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77620774
75tricarboxylic acid cycle (GO:0006099)2.76936467
76hydrogen transport (GO:0006818)2.76747173
77presynaptic membrane assembly (GO:0097105)2.76411736
78protein neddylation (GO:0045116)2.75764811
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75309243
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75309243
81anterograde synaptic vesicle transport (GO:0048490)2.74551314
82positive regulation of ligase activity (GO:0051351)2.73643276
83cholesterol biosynthetic process (GO:0006695)2.72604861
84response to redox state (GO:0051775)2.72167799
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70454161
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70432012
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70432012
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70432012
89ATP hydrolysis coupled proton transport (GO:0015991)2.69867892
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.69867892
91presynaptic membrane organization (GO:0097090)2.69839691
92oligosaccharide catabolic process (GO:0009313)2.68373571
93cell redox homeostasis (GO:0045454)2.67892470
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.67077027
95positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.66120905
96protein-cofactor linkage (GO:0018065)2.63116890
97base-excision repair, AP site formation (GO:0006285)2.62872506
98serine transport (GO:0032329)2.61832648
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61780394
100purine nucleotide salvage (GO:0032261)2.61747655
101antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.61697760
102L-serine transport (GO:0015825)2.61315758
103respiratory electron transport chain (GO:0022904)2.61083923
104fatty-acyl-CoA biosynthetic process (GO:0046949)2.59752895
105substantia nigra development (GO:0021762)2.59563703
106long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.58733137
107mitochondrial transport (GO:0006839)2.58184105
108signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57941137
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.57941137
110synaptic vesicle maturation (GO:0016188)2.57874749
111transmission of nerve impulse (GO:0019226)2.57576413
112L-amino acid import (GO:0043092)2.57437598
113pyrimidine-containing compound salvage (GO:0008655)2.55519555
114pyrimidine nucleoside salvage (GO:0043097)2.55519555
115daunorubicin metabolic process (GO:0044597)2.54389999
116polyketide metabolic process (GO:0030638)2.54389999
117doxorubicin metabolic process (GO:0044598)2.54389999
118electron transport chain (GO:0022900)2.54348402
119purine-containing compound salvage (GO:0043101)2.54288207
120cellular potassium ion homeostasis (GO:0030007)2.53542710
121signal transduction involved in cell cycle checkpoint (GO:0072395)2.52802482
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51834716
123de novo protein folding (GO:0006458)2.51527696
124heme metabolic process (GO:0042168)2.51231720
125nucleotide transmembrane transport (GO:1901679)2.50748303
126pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50638021
127very long-chain fatty acid metabolic process (GO:0000038)2.50438790
128amino acid salvage (GO:0043102)2.50179832
129L-methionine biosynthetic process (GO:0071265)2.50179832
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.48735612
131glycerophospholipid catabolic process (GO:0046475)2.47896139
132regulation of synaptic vesicle transport (GO:1902803)2.44199488
133sterol biosynthetic process (GO:0016126)2.43118575
134transferrin transport (GO:0033572)2.42992264
135fatty-acyl-CoA metabolic process (GO:0035337)2.42274806
136neurotransmitter uptake (GO:0001504)2.40399531
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.39835322
138regulation of glutamate secretion (GO:0014048)2.37242439
139neurotransmitter secretion (GO:0007269)2.36315411
140neurotransmitter catabolic process (GO:0042135)2.34948506
141trivalent inorganic cation transport (GO:0072512)2.34818486
142ferric iron transport (GO:0015682)2.34818486
143acyl-CoA biosynthetic process (GO:0071616)2.34506429
144thioester biosynthetic process (GO:0035384)2.34506429
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.34396189
146glutamate receptor signaling pathway (GO:0007215)2.34308585
147creatine metabolic process (GO:0006600)2.33545456
148cerebellar granule cell differentiation (GO:0021707)2.32011718
149import into cell (GO:0098657)2.29600162
150regulation of amyloid precursor protein catabolic process (GO:1902991)2.26910249
151oligodendrocyte differentiation (GO:0048709)2.25333250
152signal peptide processing (GO:0006465)2.25148167
153acidic amino acid transport (GO:0015800)2.25134918
154neuron-neuron synaptic transmission (GO:0007270)2.24828714
155neurotransmitter transport (GO:0006836)2.24771104
156amino acid import (GO:0043090)2.24371061
157negative regulation of protein localization to cell surface (GO:2000009)2.23853474
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.23025978
159ATP synthesis coupled proton transport (GO:0015986)2.23025978
160synaptic transmission, glutamatergic (GO:0035249)2.22041626
161adult walking behavior (GO:0007628)2.21628782
162neuron remodeling (GO:0016322)2.20656258
163cellular copper ion homeostasis (GO:0006878)2.18555601
164vocalization behavior (GO:0071625)2.17814736
165myelin maintenance (GO:0043217)2.17510590
166neuromuscular process controlling posture (GO:0050884)2.16851409
167L-glutamate transport (GO:0015813)2.16511515
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16252521
169negative regulation of synaptic transmission (GO:0050805)2.15708753
170aldehyde catabolic process (GO:0046185)2.14515833
171peptidyl-cysteine modification (GO:0018198)2.14270636
172aromatic amino acid family catabolic process (GO:0009074)2.14051124
173protein localization to synapse (GO:0035418)2.13576985
174positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.13251537
175regulation of neurotransmitter levels (GO:0001505)2.11950314
176regulation of voltage-gated calcium channel activity (GO:1901385)2.10891495
177regulation of long-term neuronal synaptic plasticity (GO:0048169)2.09950025
178response to dietary excess (GO:0002021)2.09662148
179magnesium ion transport (GO:0015693)2.09620099
180regulation of neuronal synaptic plasticity (GO:0048168)2.08841052
181glycosylceramide metabolic process (GO:0006677)2.08448464
182neuron recognition (GO:0008038)2.07785911
183pH reduction (GO:0045851)2.07271748
184regulation of vesicle fusion (GO:0031338)2.05736568
185phagosome maturation (GO:0090382)2.05198439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.81168590
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21733965
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.09710934
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.02604399
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.52554414
6GBX2_23144817_ChIP-Seq_PC3_Human3.47664299
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.43538071
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.31404513
9EZH2_22144423_ChIP-Seq_EOC_Human3.02356824
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88950627
11ZNF263_19887448_ChIP-Seq_K562_Human2.78631886
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62616565
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61754355
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.56864795
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.56453906
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.51284206
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41053142
18DCP1A_22483619_ChIP-Seq_HELA_Human2.36719902
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35161389
20TAF15_26573619_Chip-Seq_HEK293_Human2.32581942
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.27733731
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.25308413
23GABP_19822575_ChIP-Seq_HepG2_Human2.25223070
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24877275
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24459871
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21327490
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19109950
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18955413
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17784251
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16172837
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14414163
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14368421
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13964602
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12783680
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04687488
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.02469673
37VDR_23849224_ChIP-Seq_CD4+_Human2.01037098
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97719980
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95820021
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95820021
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95173369
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.94811447
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90872419
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88240101
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.87842571
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87761285
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87643210
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87542833
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.83983607
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82347198
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80296627
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76268373
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.76217897
54VDR_22108803_ChIP-Seq_LS180_Human1.75629530
55ELK1_19687146_ChIP-ChIP_HELA_Human1.73285663
56REST_21632747_ChIP-Seq_MESCs_Mouse1.72594357
57TFEB_21752829_ChIP-Seq_HELA_Human1.71522480
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70386144
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.68741918
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66779010
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66524355
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65167752
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64625253
64AR_21572438_ChIP-Seq_LNCaP_Human1.64487488
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63662065
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60509431
67FOXP3_21729870_ChIP-Seq_TREG_Human1.60032383
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59646103
69XRN2_22483619_ChIP-Seq_HELA_Human1.59615067
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58852450
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.54885538
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.53211296
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53199861
74P300_19829295_ChIP-Seq_ESCs_Human1.52958822
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52623938
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52417902
77ER_23166858_ChIP-Seq_MCF-7_Human1.50297095
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48555502
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.46040392
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.44411351
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44293119
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.43761642
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43391016
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43008075
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43008075
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.41565486
87HTT_18923047_ChIP-ChIP_STHdh_Human1.41419862
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.37632380
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37072353
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36950107
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36498883
92TTF2_22483619_ChIP-Seq_HELA_Human1.35693964
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31365051
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31237729
95SMAD4_21799915_ChIP-Seq_A2780_Human1.30976095
96DROSHA_22980978_ChIP-Seq_HELA_Human1.30951559
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29914149
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29182116
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28952802
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27205944
101RXR_22158963_ChIP-Seq_LIVER_Mouse1.27000256
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26651575
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.26490952
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25277545
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25218675
106RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24794088
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23943812
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23889377
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.23168582
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22290914
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22035314
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21492216
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.21444858
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21246509
115TBX5_21415370_ChIP-Seq_HL-1_Mouse1.18940929
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17658688
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15181925
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14450771
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12445855
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11323738
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.10845507
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10594078
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.10462231
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09974208
125HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09230178
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08024557
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07880854
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07359650
129AR_25329375_ChIP-Seq_VCAP_Human1.06402585
130BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04820424
131IGF1R_20145208_ChIP-Seq_DFB_Human1.04001957
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03729223
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03298464
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02373109
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01913583
136JUN_21703547_ChIP-Seq_K562_Human1.01149139
137CLOCK_20551151_ChIP-Seq_293T_Human1.00414530
138TET1_21451524_ChIP-Seq_MESCs_Mouse0.99875655
139NANOG_19829295_ChIP-Seq_ESCs_Human0.99182573
140SOX2_19829295_ChIP-Seq_ESCs_Human0.99182573
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.99178028
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98772970
143STAT3_23295773_ChIP-Seq_U87_Human0.97351746
144RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96472080
145TP53_18474530_ChIP-ChIP_U2OS_Human0.96043549
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95744672
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.95473831
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95242711
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95152049
150MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94626904
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.94293593
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93960265
153TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93881036
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93545866
155ZNF274_21170338_ChIP-Seq_K562_Hela0.91358185
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91317063
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91260924
158RUNX2_22187159_ChIP-Seq_PCA_Human0.91088011
159MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90616604
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.90170486
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.88852581
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88824901
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88182291
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.87751480
165PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87560928
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87532258
167KDM5A_27292631_Chip-Seq_BREAST_Human0.87352906
168P53_22387025_ChIP-Seq_ESCs_Mouse0.85509131
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.84981840
170CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84899560
171NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84823532
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.84359772
173EOMES_21245162_ChIP-Seq_HESCs_Human0.83838246
174PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83587020
175EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83371624
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83118461
177TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82919634
178BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82850527
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82733669
180FOXP1_21924763_ChIP-Seq_HESCs_Human0.81415060
181P300_18555785_Chip-Seq_ESCs_Mouse0.81390203
182KDM2B_26808549_Chip-Seq_REH_Human0.81142494
183BCL6_27268052_Chip-Seq_Bcells_Human0.80494734
184TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79767096
185BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77744127
186FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75565023
187CTCF_26484167_Chip-Seq_Bcells_Mouse0.75186468
188JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74148387
189RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74007702
190SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73857284
191PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73639721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.93073302
2MP0009840_abnormal_foam_cell3.79266507
3MP0008438_abnormal_cutaneous_collagen3.49355526
4MP0004859_abnormal_synaptic_plasticity3.11163550
5MP0006082_CNS_inflammation3.06777188
6MP0004270_analgesia2.90796609
7MP0004510_myositis2.90381742
8MP0000343_altered_response_to2.77790854
9MP0000920_abnormal_myelination2.76311274
10MP0003011_delayed_dark_adaptation2.62814548
11MP0003329_amyloid_beta_deposits2.62769268
12MP0003186_abnormal_redox_activity2.61596594
13MP0003635_abnormal_synaptic_transmissio2.59025435
14MP0002064_seizures2.57081130
15MP0003195_calcinosis2.56011115
16MP0009046_muscle_twitch2.51460049
17MP0002272_abnormal_nervous_system2.39295310
18MP0009745_abnormal_behavioral_response2.34052707
19MP0001727_abnormal_embryo_implantation2.24899674
20MP0003690_abnormal_glial_cell2.15367120
21MP0001542_abnormal_bone_strength2.14473980
22MP0002139_abnormal_hepatobiliary_system2.12276797
23MP0003122_maternal_imprinting2.02471748
24MP0004043_abnormal_pH_regulation2.01950256
25MP0002734_abnormal_mechanical_nocicepti1.99614760
26MP0001968_abnormal_touch/_nociception1.98811666
27MP0001486_abnormal_startle_reflex1.97814141
28MP0003806_abnormal_nucleotide_metabolis1.92126491
29MP0001905_abnormal_dopamine_level1.91390251
30MP0002063_abnormal_learning/memory/cond1.91003828
31MP0001440_abnormal_grooming_behavior1.86412581
32MP0001529_abnormal_vocalization1.86326141
33MP0001853_heart_inflammation1.85802908
34MP0005623_abnormal_meninges_morphology1.85053134
35MP0002572_abnormal_emotion/affect_behav1.84341803
36MP0005423_abnormal_somatic_nervous1.79810878
37MP0009764_decreased_sensitivity_to1.77333092
38MP0001501_abnormal_sleep_pattern1.77286705
39MP0002736_abnormal_nociception_after1.70803890
40MP0004142_abnormal_muscle_tone1.69853197
41MP0000604_amyloidosis1.68501061
42MP0002822_catalepsy1.67746952
43MP0008875_abnormal_xenobiotic_pharmacok1.63787240
44MP0005360_urolithiasis1.60353803
45MP0005551_abnormal_eye_electrophysiolog1.58153695
46MP0006054_spinal_hemorrhage1.57208371
47MP0004885_abnormal_endolymph1.52911005
48MP0002102_abnormal_ear_morphology1.52029004
49MP0002148_abnormal_hypersensitivity_rea1.52008781
50MP0001984_abnormal_olfaction1.51583814
51MP0005257_abnormal_intraocular_pressure1.51124931
52MP0002067_abnormal_sensory_capabilities1.50935449
53MP0003633_abnormal_nervous_system1.50302893
54MP0002735_abnormal_chemical_nociception1.50199492
55MP0003646_muscle_fatigue1.50122305
56MP0010386_abnormal_urinary_bladder1.48731691
57MP0001970_abnormal_pain_threshold1.47716123
58MP0002229_neurodegeneration1.46518230
59MP0006035_abnormal_mitochondrial_morpho1.45931256
60MP0002733_abnormal_thermal_nociception1.45818882
61MP0005058_abnormal_lysosome_morphology1.44969323
62MP0000013_abnormal_adipose_tissue1.43364816
63MP0003191_abnormal_cellular_cholesterol1.42728187
64MP0006276_abnormal_autonomic_nervous1.41666729
65MP0003634_abnormal_glial_cell1.41238571
66MP0005646_abnormal_pituitary_gland1.39814680
67MP0005408_hypopigmentation1.39803171
68MP0002877_abnormal_melanocyte_morpholog1.39773525
69MP0005085_abnormal_gallbladder_physiolo1.39393089
70MP0005332_abnormal_amino_acid1.38810405
71MP0009785_altered_susceptibility_to1.37048436
72MP0003786_premature_aging1.34698491
73MP0002876_abnormal_thyroid_physiology1.34354468
74MP0004924_abnormal_behavior1.32159825
75MP0005386_behavior/neurological_phenoty1.32159825
76MP0008569_lethality_at_weaning1.30692531
77MP0002090_abnormal_vision1.30246093
78MP0004147_increased_porphyrin_level1.29871140
79MP0003121_genomic_imprinting1.29639297
80MP0003631_nervous_system_phenotype1.27864364
81MP0005165_increased_susceptibility_to1.27079191
82MP0000751_myopathy1.26975656
83MP0001502_abnormal_circadian_rhythm1.26213556
84MP0000358_abnormal_cell_content/1.25496381
85MP0004742_abnormal_vestibular_system1.24935711
86MP0005645_abnormal_hypothalamus_physiol1.22980501
87MP0003172_abnormal_lysosome_physiology1.22196058
88MP0005171_absent_coat_pigmentation1.20814408
89MP0005083_abnormal_biliary_tract1.17932066
90MP0002066_abnormal_motor_capabilities/c1.16126963
91MP0005535_abnormal_body_temperature1.15979990
92MP0009780_abnormal_chondrocyte_physiolo1.15950066
93MP0005365_abnormal_bile_salt1.15410318
94MP0000750_abnormal_muscle_regeneration1.14427056
95MP0001756_abnormal_urination1.13450913
96MP0005164_abnormal_response_to1.12225929
97MP0009765_abnormal_xenobiotic_induced1.10933042
98MP0003279_aneurysm1.10387634
99MP0004233_abnormal_muscle_weight1.09294814
100MP0005319_abnormal_enzyme/_coenzyme1.09173086
101MP0004272_abnormal_basement_membrane1.07492203
102MP0002909_abnormal_adrenal_gland1.07148728
103MP0003632_abnormal_nervous_system1.05967992
104MP0002332_abnormal_exercise_endurance1.05336894
105MP0005584_abnormal_enzyme/coenzyme_acti1.03718716
106MP0001485_abnormal_pinna_reflex1.01342886
107MP0002882_abnormal_neuron_morphology1.01276522
108MP0000749_muscle_degeneration1.01207364
109MP0000778_abnormal_nervous_system1.00498669
110MP0000955_abnormal_spinal_cord1.00029600
111MP0009763_increased_sensitivity_to0.99551821
112MP0003950_abnormal_plasma_membrane0.97600854
113MP0003656_abnormal_erythrocyte_physiolo0.97227505
114MP0008469_abnormal_protein_level0.96226554
115MP0002118_abnormal_lipid_homeostasis0.95814362
116MP0002295_abnormal_pulmonary_circulatio0.95289019
117MP0002557_abnormal_social/conspecific_i0.94545064
118MP0006072_abnormal_retinal_apoptosis0.94433237
119MP0008789_abnormal_olfactory_epithelium0.93423843
120MP0002837_dystrophic_cardiac_calcinosis0.92080371
121MP0001533_abnormal_skeleton_physiology0.91826084
122MP0001666_abnormal_nutrient_absorption0.91356705
123MP0003075_altered_response_to0.90454849
124MP0009384_cardiac_valve_regurgitation0.89301519
125MP0002184_abnormal_innervation0.89260097
126MP0003879_abnormal_hair_cell0.87277210
127MP0005671_abnormal_response_to0.85721900
128MP0005636_abnormal_mineral_homeostasis0.85540214
129MP0000230_abnormal_systemic_arterial0.84906272
130MP0002638_abnormal_pupillary_reflex0.84112567
131MP0005379_endocrine/exocrine_gland_phen0.83849653
132MP0001963_abnormal_hearing_physiology0.82217719
133MP0005167_abnormal_blood-brain_barrier0.81973546
134MP0003941_abnormal_skin_development0.81377354
135MP0000372_irregular_coat_pigmentation0.80808783
136MP0001764_abnormal_homeostasis0.80439644
137MP0001765_abnormal_ion_homeostasis0.79870844
138MP0005084_abnormal_gallbladder_morpholo0.79763530
139MP0008260_abnormal_autophagy0.79437810
140MP0005595_abnormal_vascular_smooth0.78976322
141MP0001243_abnormal_dermal_layer0.78493773
142MP0001661_extended_life_span0.75835624
143MP0010329_abnormal_lipoprotein_level0.74478674
144MP0001177_atelectasis0.74433544
145MP0003868_abnormal_feces_composition0.74171316
146MP0001299_abnormal_eye_distance/0.73535463
147MP0002069_abnormal_eating/drinking_beha0.72733572
148MP0008058_abnormal_DNA_repair0.72316268
149MP0006036_abnormal_mitochondrial_physio0.71881232
150MP0005410_abnormal_fertilization0.71028387
151MP0005451_abnormal_body_composition0.70745129
152MP0000858_altered_metastatic_potential0.70640194
153MP0002277_abnormal_respiratory_mucosa0.68975468
154MP0002933_joint_inflammation0.67229157
155MP0003137_abnormal_impulse_conducting0.66887145
156MP0001270_distended_abdomen0.66415029
157MP0009333_abnormal_splenocyte_physiolog0.66031291
158MP0008775_abnormal_heart_ventricle0.65365096
159MP0002060_abnormal_skin_morphology0.65180466
160MP0009643_abnormal_urine_homeostasis0.62939513
161MP0005390_skeleton_phenotype0.61321911

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.15161077
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.15161077
3Abnormality of glycolipid metabolism (HP:0010969)5.15161077
4Neurofibrillary tangles (HP:0002185)4.51257311
5Focal motor seizures (HP:0011153)3.92224089
6Myokymia (HP:0002411)3.56904577
7Vertebral compression fractures (HP:0002953)3.33029313
8Retinal dysplasia (HP:0007973)3.30433235
9Cerebral inclusion bodies (HP:0100314)3.27731807
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.19634519
11Pheochromocytoma (HP:0002666)3.08758358
12Supranuclear gaze palsy (HP:0000605)3.02643783
13Acute necrotizing encephalopathy (HP:0006965)3.02514097
14Increased muscle lipid content (HP:0009058)3.02470825
15Atonic seizures (HP:0010819)2.99806545
16Acute encephalopathy (HP:0006846)2.93231457
17Neuroendocrine neoplasm (HP:0100634)2.90850765
18Type I transferrin isoform profile (HP:0003642)2.89616386
19Abnormal mitochondria in muscle tissue (HP:0008316)2.84905760
20Cutaneous melanoma (HP:0012056)2.84770859
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78663124
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.78663124
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74456953
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74365374
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71222384
26Abnormality of polysaccharide metabolism (HP:0011012)2.71222384
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71222384
28Epileptic encephalopathy (HP:0200134)2.70615172
29Progressive macrocephaly (HP:0004481)2.68425139
30Mitochondrial inheritance (HP:0001427)2.65948992
31Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65718120
32Generalized aminoaciduria (HP:0002909)2.65497273
33Dysmetria (HP:0001310)2.64362151
34Progressive neurologic deterioration (HP:0002344)2.62696656
35Abnormal glycosylation (HP:0012345)2.61573484
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61573484
37Abnormal protein N-linked glycosylation (HP:0012347)2.61573484
38Abnormal protein glycosylation (HP:0012346)2.61573484
39Hypokinesia (HP:0002375)2.54860840
40Hyperventilation (HP:0002883)2.54085348
41Scanning speech (HP:0002168)2.54027001
42Emotional lability (HP:0000712)2.51396249
43Spastic paraparesis (HP:0002313)2.50593807
44Urinary glycosaminoglycan excretion (HP:0003541)2.48717244
45Mucopolysacchariduria (HP:0008155)2.48717244
46Sensory axonal neuropathy (HP:0003390)2.48161572
47Exercise intolerance (HP:0003546)2.47594287
48Cerebral hemorrhage (HP:0001342)2.46975149
49Hyperlipoproteinemia (HP:0010980)2.46843017
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44355635
51Hepatocellular necrosis (HP:0001404)2.44120974
52Focal seizures (HP:0007359)2.41096289
53Increased serum lactate (HP:0002151)2.39784518
54Renal Fanconi syndrome (HP:0001994)2.39395980
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38562031
56Dicarboxylic aciduria (HP:0003215)2.38562031
57Absence seizures (HP:0002121)2.36944259
58Abnormality of glycolysis (HP:0004366)2.35934217
59Increased serum pyruvate (HP:0003542)2.35934217
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35338521
61Generalized tonic-clonic seizures (HP:0002069)2.28669445
62Anxiety (HP:0000739)2.28358188
63Dialeptic seizures (HP:0011146)2.27280103
64Abnormality of the anterior horn cell (HP:0006802)2.24850049
65Degeneration of anterior horn cells (HP:0002398)2.24850049
66Intention tremor (HP:0002080)2.24602118
67Progressive inability to walk (HP:0002505)2.23351487
68Beaking of vertebral bodies (HP:0004568)2.22873755
69Increased CSF lactate (HP:0002490)2.21612581
70Leukodystrophy (HP:0002415)2.21543771
71Hepatic necrosis (HP:0002605)2.21063373
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20712983
73Spastic gait (HP:0002064)2.20491359
74Premature rupture of membranes (HP:0001788)2.19316888
75Parakeratosis (HP:0001036)2.19080584
76CNS demyelination (HP:0007305)2.18556378
77Type II lissencephaly (HP:0007260)2.18316840
78Visual hallucinations (HP:0002367)2.17324277
79Abnormality of the corticospinal tract (HP:0002492)2.14671130
80Xanthomatosis (HP:0000991)2.14161475
81Abnormality of macular pigmentation (HP:0008002)2.12216698
82Increased circulating renin level (HP:0000848)2.11807916
83Achilles tendon contracture (HP:0001771)2.11279909
84Opisthotonus (HP:0002179)2.11025162
85Cerebral edema (HP:0002181)2.10402495
86Generalized myoclonic seizures (HP:0002123)2.08948920
87Ragged-red muscle fibers (HP:0003200)2.08750544
88Action tremor (HP:0002345)2.08416494
89Progressive cerebellar ataxia (HP:0002073)2.08302065
90Prolonged neonatal jaundice (HP:0006579)2.05633913
91Lethargy (HP:0001254)2.04514204
92Intrahepatic cholestasis (HP:0001406)2.04283172
93Delayed gross motor development (HP:0002194)2.03838778
94Methylmalonic acidemia (HP:0002912)2.02370605
95Systemic lupus erythematosus (HP:0002725)2.00962201
96Abnormality of the Achilles tendon (HP:0005109)1.99837607
97Upper limb muscle weakness (HP:0003484)1.98744359
98Craniofacial dystonia (HP:0012179)1.98613571
99Abnormality of fatty-acid metabolism (HP:0004359)1.97007696
100Focal dystonia (HP:0004373)1.96424420
101Nausea (HP:0002018)1.96280223
102Abnormal eating behavior (HP:0100738)1.95469226
103Sensorimotor neuropathy (HP:0007141)1.95083952
104Prolonged partial thromboplastin time (HP:0003645)1.93059762
105Loss of speech (HP:0002371)1.92563755
106Neoplasm of head and neck (HP:0012288)1.91907581
107Esophageal neoplasm (HP:0100751)1.91907581
108Clumsiness (HP:0002312)1.91648468
109Dysostosis multiplex (HP:0000943)1.90607480
110Metaphyseal dysplasia (HP:0100255)1.90390734
111Hypokalemic alkalosis (HP:0001949)1.90068788
112Hyperglycinemia (HP:0002154)1.88907642
1133-Methylglutaconic aciduria (HP:0003535)1.88607135
114Hepatosplenomegaly (HP:0001433)1.88541215
115Peripheral hypomyelination (HP:0007182)1.87800345
116Delusions (HP:0000746)1.87682811
117Megalencephaly (HP:0001355)1.86641515
118Paraparesis (HP:0002385)1.86239436
119Ovoid vertebral bodies (HP:0003300)1.85663020
120Vacuolated lymphocytes (HP:0001922)1.85500204
121Methylmalonic aciduria (HP:0012120)1.84457178
122Exertional dyspnea (HP:0002875)1.82747969
123Congenital ichthyosiform erythroderma (HP:0007431)1.82378636
124Sparse eyelashes (HP:0000653)1.82361746
125Increased hepatocellular lipid droplets (HP:0006565)1.82267020
126Ankle clonus (HP:0011448)1.81685630
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81135424
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81135424
129Respiratory failure (HP:0002878)1.81127104
130Febrile seizures (HP:0002373)1.80632549
131Split foot (HP:0001839)1.80317652
132Dysdiadochokinesis (HP:0002075)1.79899937
133Metabolic alkalosis (HP:0200114)1.78976957
134J-shaped sella turcica (HP:0002680)1.78259800
135Amyloidosis (HP:0011034)1.77514363
136Akinesia (HP:0002304)1.77470806
137Increased intramyocellular lipid droplets (HP:0012240)1.77167588
138Epileptiform EEG discharges (HP:0011182)1.76719963
139Optic disc pallor (HP:0000543)1.76143836
140Confusion (HP:0001289)1.75975171
141Abnormality of binocular vision (HP:0011514)1.75643533
142Diplopia (HP:0000651)1.75643533
143Cerebral hypomyelination (HP:0006808)1.75550544
144Cardiovascular calcification (HP:0011915)1.75383751
145Myoglobinuria (HP:0002913)1.74968401
146Rhabdomyolysis (HP:0003201)1.74953952
147Lipid accumulation in hepatocytes (HP:0006561)1.74915562
148Rough bone trabeculation (HP:0100670)1.74892539
149Psychosis (HP:0000709)1.74763334
150Polyphagia (HP:0002591)1.74392240
151Vascular calcification (HP:0004934)1.74331216
152Retinal atrophy (HP:0001105)1.73656874
153Slow saccadic eye movements (HP:0000514)1.73215725
154Autoamputation (HP:0001218)1.72500828
155Vomiting (HP:0002013)1.72399557
156Large eyes (HP:0001090)1.72220948
157EEG with generalized epileptiform discharges (HP:0011198)1.71939624
158Lactic acidosis (HP:0003128)1.71633660
159Termporal pattern (HP:0011008)1.71554653
160Insidious onset (HP:0003587)1.71554653
161Abnormal gallbladder physiology (HP:0012438)1.71213332
162Cholecystitis (HP:0001082)1.71213332
163Hypomagnesemia (HP:0002917)1.70887505
164X-linked dominant inheritance (HP:0001423)1.70252900
165Hyperammonemia (HP:0001987)1.70076225
166Thickened helices (HP:0000391)1.69863667
167Mitral stenosis (HP:0001718)1.69284983
168Axonal loss (HP:0003447)1.68613565
169Mutism (HP:0002300)1.68498265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.89451552
2TESK13.79045694
3PIM23.74869989
4OXSR13.56488933
5NME23.17844868
6EPHA42.48539116
7NTRK32.43460796
8CDK192.26867277
9WNK42.20502224
10CASK2.15193863
11ARAF2.06773461
12TNIK2.06737677
13IRAK32.03860624
14NTRK11.98339578
15PDK21.96479391
16MAP4K21.90484505
17PBK1.85005645
18MAP2K71.76179777
19EIF2AK11.70422414
20BCR1.69382842
21SCYL21.65868035
22PNCK1.65764355
23PRPF4B1.61649694
24MYLK1.60817957
25CAMK2B1.59607467
26MAPKAPK51.57383249
27MAP3K121.56767458
28MAP3K41.49090410
29LIMK11.47425184
30MAP3K111.45128466
31MAPK151.42390574
32CAMK2D1.40217974
33KIT1.37231809
34MARK11.36422484
35CAMKK21.35790503
36MINK11.35663722
37RIPK41.34666223
38SGK4941.32881374
39SGK2231.32881374
40PKN11.31465599
41VRK21.26255116
42LMTK21.26251304
43INSRR1.25796629
44CSNK1G31.25031409
45CAMK2G1.24811695
46MAP3K91.24129812
47PAK41.23639255
48KDR1.22462386
49EPHB11.22024884
50FGFR21.20611548
51CAMK2A1.20117931
52BCKDK1.19427443
53CSNK1G21.18492049
54TGFBR21.18320283
55DAPK21.17990512
56TBK11.13714110
57NEK61.12856176
58CDK51.12028277
59GRK71.11667238
60NEK11.10359745
61ERN11.09450691
62WNK11.08970810
63BMPR21.05473091
64CSNK1A1L1.04968043
65MAP2K41.04848722
66UHMK11.03120319
67MAPKAPK31.02870902
68NME11.02618978
69PLK21.02278247
70PAK61.01529733
71MAP3K21.00482515
72GRK51.00463182
73STK161.00258555
74KSR20.99455359
75NTRK20.98866220
76TXK0.95588664
77MAP3K140.94009930
78IKBKB0.93887693
79TAOK20.93837250
80PAK30.93113971
81PRKCG0.91112372
82CDK140.90574264
83FES0.90316208
84PINK10.87282422
85MET0.87261192
86PRKCE0.86212386
87MAP3K50.85078105
88CSNK1G10.83930201
89IRAK10.83919426
90ABL20.83216352
91WNK30.82711208
92EPHA20.81719284
93PDPK10.80977473
94DDR20.80692124
95BUB10.78091809
96MAP3K30.77280501
97DAPK10.77054103
98MAP3K10.74929836
99PTK2B0.74831220
100SRPK10.74825220
101ROCK20.74589454
102EIF2AK30.73977967
103MAP3K130.73654194
104TAOK30.73366492
105BMPR1B0.72277783
106EPHB20.70493897
107IRAK20.69498251
108BRAF0.69484470
109CDK150.67715064
110ERBB40.66614902
111ILK0.66456672
112CDK180.66425201
113ERBB30.64820724
114AURKA0.64605282
115MUSK0.63702624
116PTK20.62741671
117CCNB10.60120111
118CAMKK10.60090698
119TRIM280.60036935
120DYRK30.57037548
121PHKG10.56883873
122PHKG20.56883873
123TNK20.56475604
124MST40.55987738
125CDK11A0.55231560
126IRAK40.55153773
127PRKCQ0.54989919
128PAK20.54864493
129DYRK1A0.54727426
130STK100.53928360
131CAMK10.51305689
132PAK10.51123398
133ADRBK20.50862305
134PDK10.50419086
135TESK20.50364235
136MAPK130.50309157
137DAPK30.49965671
138CSNK1A10.49287757
139FGR0.48598468
140PRKACA0.48187140
141ADRBK10.48066567
142PRKCI0.46850261
143PRKG10.46091363
144MOS0.45377193
145FER0.44576645
146RPS6KA50.44135858
147GRK10.42717617
148CSNK2A10.42661540
149CSNK2A20.40426486
150LRRK20.39036357
151DYRK20.38764365
152ABL10.36982872
153TAOK10.35865418
154MST1R0.33571377
155RAF10.33533663
156PRKG20.32594964
157SRC0.32354445

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.94161666
2Oxidative phosphorylation_Homo sapiens_hsa001902.69092447
3Fatty acid elongation_Homo sapiens_hsa000622.46529035
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44732698
5Steroid biosynthesis_Homo sapiens_hsa001002.43232212
6Synaptic vesicle cycle_Homo sapiens_hsa047212.16799622
7Collecting duct acid secretion_Homo sapiens_hsa049662.16323542
8Sulfur metabolism_Homo sapiens_hsa009202.15198988
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15002269
10Protein export_Homo sapiens_hsa030602.11689863
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07788810
12Nicotine addiction_Homo sapiens_hsa050332.06610652
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05411741
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.03163178
15GABAergic synapse_Homo sapiens_hsa047271.92777564
16Parkinsons disease_Homo sapiens_hsa050121.84416579
17Butanoate metabolism_Homo sapiens_hsa006501.77059097
18Nitrogen metabolism_Homo sapiens_hsa009101.74564434
19Vibrio cholerae infection_Homo sapiens_hsa051101.74509380
20Alzheimers disease_Homo sapiens_hsa050101.72328534
21Other glycan degradation_Homo sapiens_hsa005111.70659660
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63246332
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48464729
24Glutamatergic synapse_Homo sapiens_hsa047241.43392912
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.38934754
26Morphine addiction_Homo sapiens_hsa050321.37906830
27Sulfur relay system_Homo sapiens_hsa041221.35278444
28RNA polymerase_Homo sapiens_hsa030201.33978021
29Serotonergic synapse_Homo sapiens_hsa047261.31628098
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27295960
31Glutathione metabolism_Homo sapiens_hsa004801.25627194
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24799985
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24409419
34Circadian entrainment_Homo sapiens_hsa047131.24071096
35Ether lipid metabolism_Homo sapiens_hsa005651.23792734
36Ribosome_Homo sapiens_hsa030101.22988752
37Carbon metabolism_Homo sapiens_hsa012001.20297710
38Histidine metabolism_Homo sapiens_hsa003401.17672245
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16070139
40Pyrimidine metabolism_Homo sapiens_hsa002401.14895173
41Propanoate metabolism_Homo sapiens_hsa006401.14618370
42N-Glycan biosynthesis_Homo sapiens_hsa005101.14217680
43Taste transduction_Homo sapiens_hsa047421.13317829
44Olfactory transduction_Homo sapiens_hsa047401.12181761
45Galactose metabolism_Homo sapiens_hsa000521.11996411
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11978817
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11928430
48Peroxisome_Homo sapiens_hsa041461.11491651
49Insulin secretion_Homo sapiens_hsa049111.11370154
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11141456
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08921057
52Vitamin B6 metabolism_Homo sapiens_hsa007501.08587857
53Salivary secretion_Homo sapiens_hsa049701.07978799
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07610297
55Long-term potentiation_Homo sapiens_hsa047201.04957520
56Fatty acid metabolism_Homo sapiens_hsa012121.01815762
57Amphetamine addiction_Homo sapiens_hsa050311.01754738
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01699094
59Sphingolipid metabolism_Homo sapiens_hsa006001.00922820
60Huntingtons disease_Homo sapiens_hsa050160.99204181
61Biosynthesis of amino acids_Homo sapiens_hsa012300.99190852
62Pyruvate metabolism_Homo sapiens_hsa006200.99086729
63Phototransduction_Homo sapiens_hsa047440.99027937
64Rheumatoid arthritis_Homo sapiens_hsa053230.98835449
65Long-term depression_Homo sapiens_hsa047300.97542612
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96189900
67Dopaminergic synapse_Homo sapiens_hsa047280.95543765
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94660534
69Cardiac muscle contraction_Homo sapiens_hsa042600.93814730
70Lysosome_Homo sapiens_hsa041420.92821552
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92688241
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.90298886
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86191530
74Cocaine addiction_Homo sapiens_hsa050300.85939130
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85757968
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85724138
77Pancreatic secretion_Homo sapiens_hsa049720.84672399
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83859850
79Arginine and proline metabolism_Homo sapiens_hsa003300.83108737
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81946056
81Phenylalanine metabolism_Homo sapiens_hsa003600.81063133
82Arginine biosynthesis_Homo sapiens_hsa002200.80771655
83Gastric acid secretion_Homo sapiens_hsa049710.80554067
84Fatty acid degradation_Homo sapiens_hsa000710.79502912
85Bile secretion_Homo sapiens_hsa049760.79257297
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78945938
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.76767478
88Cholinergic synapse_Homo sapiens_hsa047250.74907822
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73781682
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71547313
91Renin secretion_Homo sapiens_hsa049240.68604646
92beta-Alanine metabolism_Homo sapiens_hsa004100.67966955
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.67247901
94Folate biosynthesis_Homo sapiens_hsa007900.66554777
95Complement and coagulation cascades_Homo sapiens_hsa046100.65883322
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.64836655
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64481395
98Tryptophan metabolism_Homo sapiens_hsa003800.64462325
99Chemical carcinogenesis_Homo sapiens_hsa052040.63755274
100Phagosome_Homo sapiens_hsa041450.63413486
101Purine metabolism_Homo sapiens_hsa002300.61690371
102Shigellosis_Homo sapiens_hsa051310.61404471
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61265787
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61110958
105Prion diseases_Homo sapiens_hsa050200.60215462
106Linoleic acid metabolism_Homo sapiens_hsa005910.57824813
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56994370
108Metabolic pathways_Homo sapiens_hsa011000.55697577
109Calcium signaling pathway_Homo sapiens_hsa040200.54874552
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54043227
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53152955
112Fructose and mannose metabolism_Homo sapiens_hsa000510.53028739
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52490846
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.51222896
115Pertussis_Homo sapiens_hsa051330.51048800
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50974054
117Thyroid hormone synthesis_Homo sapiens_hsa049180.50466305
118Mineral absorption_Homo sapiens_hsa049780.50208596
119PPAR signaling pathway_Homo sapiens_hsa033200.50032901
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.49976996
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48750624
122Tyrosine metabolism_Homo sapiens_hsa003500.48020409
123Salmonella infection_Homo sapiens_hsa051320.47097694
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46813553
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45733806
126Fatty acid biosynthesis_Homo sapiens_hsa000610.45571023
127Legionellosis_Homo sapiens_hsa051340.43079896
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43034838
129Regulation of autophagy_Homo sapiens_hsa041400.41107801
130Pentose phosphate pathway_Homo sapiens_hsa000300.40438698
131Glycerolipid metabolism_Homo sapiens_hsa005610.39885437
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39645993
133Base excision repair_Homo sapiens_hsa034100.36186487
134Selenocompound metabolism_Homo sapiens_hsa004500.36129273
135Spliceosome_Homo sapiens_hsa030400.34482681
136One carbon pool by folate_Homo sapiens_hsa006700.33855817
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31343070
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28119564
139Retinol metabolism_Homo sapiens_hsa008300.21512997
140Renin-angiotensin system_Homo sapiens_hsa046140.21458654

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