| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.67028341 |
| 2 | Breast hypoplasia (HP:0003187) | 4.53607194 |
| 3 | Cerebral hypomyelination (HP:0006808) | 4.36157731 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 4.09772976 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.06882742 |
| 6 | Reticulocytopenia (HP:0001896) | 3.90836210 |
| 7 | Oral leukoplakia (HP:0002745) | 3.76886559 |
| 8 | Acute encephalopathy (HP:0006846) | 3.71306747 |
| 9 | Mitochondrial inheritance (HP:0001427) | 3.69317396 |
| 10 | Increased CSF lactate (HP:0002490) | 3.52364103 |
| 11 | Colon cancer (HP:0003003) | 3.50915882 |
| 12 | Selective tooth agenesis (HP:0001592) | 3.50383919 |
| 13 | Rough bone trabeculation (HP:0100670) | 3.49808382 |
| 14 | Patellar aplasia (HP:0006443) | 3.42575528 |
| 15 | Microvesicular hepatic steatosis (HP:0001414) | 3.34339209 |
| 16 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.32840440 |
| 17 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.29143691 |
| 18 | Increased hepatocellular lipid droplets (HP:0006565) | 3.23261654 |
| 19 | Increased intramyocellular lipid droplets (HP:0012240) | 3.10935816 |
| 20 | Abnormal number of erythroid precursors (HP:0012131) | 3.08660901 |
| 21 | Hepatocellular necrosis (HP:0001404) | 3.07706757 |
| 22 | Absent radius (HP:0003974) | 3.06997305 |
| 23 | Abnormal number of incisors (HP:0011064) | 3.06005848 |
| 24 | Lipid accumulation in hepatocytes (HP:0006561) | 3.05748787 |
| 25 | Medulloblastoma (HP:0002885) | 3.05143727 |
| 26 | Abnormality of the anterior horn cell (HP:0006802) | 3.04474638 |
| 27 | Degeneration of anterior horn cells (HP:0002398) | 3.04474638 |
| 28 | Premature ovarian failure (HP:0008209) | 3.02894742 |
| 29 | Abnormality of the labia minora (HP:0012880) | 3.01322998 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.97084857 |
| 31 | Ependymoma (HP:0002888) | 2.91746506 |
| 32 | Carpal bone hypoplasia (HP:0001498) | 2.91115083 |
| 33 | Absent forearm bone (HP:0003953) | 2.89395288 |
| 34 | Aplasia involving forearm bones (HP:0009822) | 2.89395288 |
| 35 | Supernumerary spleens (HP:0009799) | 2.88323342 |
| 36 | Premature graying of hair (HP:0002216) | 2.81891923 |
| 37 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.79648464 |
| 38 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.72673065 |
| 39 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.72058117 |
| 40 | Increased muscle lipid content (HP:0009058) | 2.69961382 |
| 41 | Lactic acidosis (HP:0003128) | 2.69773709 |
| 42 | Horseshoe kidney (HP:0000085) | 2.68994804 |
| 43 | Hepatic necrosis (HP:0002605) | 2.68721329 |
| 44 | Cerebral edema (HP:0002181) | 2.64083176 |
| 45 | Absent thumb (HP:0009777) | 2.64012050 |
| 46 | Macrocytic anemia (HP:0001972) | 2.62404704 |
| 47 | Trismus (HP:0000211) | 2.60986596 |
| 48 | Abnormal trabecular bone morphology (HP:0100671) | 2.58809908 |
| 49 | Exercise intolerance (HP:0003546) | 2.56061107 |
| 50 | Neoplasm of the pancreas (HP:0002894) | 2.51436214 |
| 51 | Renal Fanconi syndrome (HP:0001994) | 2.51130660 |
| 52 | Abnormality of abdominal situs (HP:0011620) | 2.49395441 |
| 53 | Abdominal situs inversus (HP:0003363) | 2.49395441 |
| 54 | Chromsome breakage (HP:0040012) | 2.49194007 |
| 55 | Rhabdomyosarcoma (HP:0002859) | 2.45667364 |
| 56 | Tracheoesophageal fistula (HP:0002575) | 2.45546466 |
| 57 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.45051388 |
| 58 | Meckel diverticulum (HP:0002245) | 2.44249394 |
| 59 | Progressive external ophthalmoplegia (HP:0000590) | 2.42274012 |
| 60 | Pallor (HP:0000980) | 2.41019211 |
| 61 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.35742450 |
| 62 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.35742450 |
| 63 | Single umbilical artery (HP:0001195) | 2.35742450 |
| 64 | Atresia of the external auditory canal (HP:0000413) | 2.35695126 |
| 65 | CNS hypomyelination (HP:0003429) | 2.34007946 |
| 66 | Abnormality of the ileum (HP:0001549) | 2.31118562 |
| 67 | Secondary amenorrhea (HP:0000869) | 2.29545797 |
| 68 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.29003334 |
| 69 | Sparse eyelashes (HP:0000653) | 2.28241081 |
| 70 | Squamous cell carcinoma (HP:0002860) | 2.26803945 |
| 71 | Duplicated collecting system (HP:0000081) | 2.26457019 |
| 72 | Respiratory failure (HP:0002878) | 2.26418182 |
| 73 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.24871876 |
| 74 | 3-Methylglutaconic aciduria (HP:0003535) | 2.22165310 |
| 75 | Multiple enchondromatosis (HP:0005701) | 2.20862876 |
| 76 | Abnormality of the umbilical cord (HP:0010881) | 2.20718612 |
| 77 | Cellular immunodeficiency (HP:0005374) | 2.19554805 |
| 78 | Asplenia (HP:0001746) | 2.19453150 |
| 79 | Neoplasm of striated muscle (HP:0009728) | 2.17485829 |
| 80 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.17110956 |
| 81 | Triphalangeal thumb (HP:0001199) | 2.14118899 |
| 82 | Basal cell carcinoma (HP:0002671) | 2.13350375 |
| 83 | Glossoptosis (HP:0000162) | 2.13150390 |
| 84 | Ragged-red muscle fibers (HP:0003200) | 2.12936554 |
| 85 | Glioma (HP:0009733) | 2.11775039 |
| 86 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.10505959 |
| 87 | Microretrognathia (HP:0000308) | 2.09831033 |
| 88 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.07099211 |
| 89 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.06576131 |
| 90 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.06576131 |
| 91 | Breast aplasia (HP:0100783) | 2.05536469 |
| 92 | Hypoplasia of the pons (HP:0012110) | 2.05449743 |
| 93 | Abnormality of the preputium (HP:0100587) | 2.05206905 |
| 94 | Concave nail (HP:0001598) | 2.04337200 |
| 95 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 2.04021480 |
| 96 | Cleft eyelid (HP:0000625) | 2.02980634 |
| 97 | Respiratory difficulties (HP:0002880) | 2.01748154 |
| 98 | Unsteady gait (HP:0002317) | 1.99776950 |
| 99 | Bone marrow hypocellularity (HP:0005528) | 1.99430954 |
| 100 | Aplastic anemia (HP:0001915) | 1.99051460 |
| 101 | Progressive muscle weakness (HP:0003323) | 1.97415768 |
| 102 | Abnormality of the astrocytes (HP:0100707) | 1.96686277 |
| 103 | Astrocytoma (HP:0009592) | 1.96686277 |
| 104 | Pancytopenia (HP:0001876) | 1.96432977 |
| 105 | Type I transferrin isoform profile (HP:0003642) | 1.96329628 |
| 106 | Abnormality of chromosome stability (HP:0003220) | 1.95773894 |
| 107 | Neoplasm of the oral cavity (HP:0100649) | 1.95736371 |
| 108 | Severe visual impairment (HP:0001141) | 1.95598295 |
| 109 | Impulsivity (HP:0100710) | 1.95334345 |
| 110 | Increased serum pyruvate (HP:0003542) | 1.94862433 |
| 111 | Rib fusion (HP:0000902) | 1.93972230 |
| 112 | Diaphragmatic weakness (HP:0009113) | 1.93824635 |
| 113 | Agnosia (HP:0010524) | 1.93228783 |
| 114 | Missing ribs (HP:0000921) | 1.92506234 |
| 115 | Increased serum lactate (HP:0002151) | 1.92046800 |
| 116 | Slender long bone (HP:0003100) | 1.91761283 |
| 117 | Postnatal microcephaly (HP:0005484) | 1.90008193 |
| 118 | Upper limb muscle weakness (HP:0003484) | 1.89891990 |
| 119 | Septo-optic dysplasia (HP:0100842) | 1.89717197 |
| 120 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.89588158 |
| 121 | Testicular atrophy (HP:0000029) | 1.88410348 |
| 122 | Abnormality of reticulocytes (HP:0004312) | 1.88372464 |
| 123 | Poor head control (HP:0002421) | 1.88192676 |
| 124 | Broad distal phalanx of finger (HP:0009836) | 1.88070558 |
| 125 | Hypoplastic pelvis (HP:0008839) | 1.87956446 |
| 126 | Personality changes (HP:0000751) | 1.85371197 |
| 127 | Stenosis of the external auditory canal (HP:0000402) | 1.84823288 |
| 128 | Hypoplasia of the radius (HP:0002984) | 1.84559912 |
| 129 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.84420460 |
| 130 | Sclerocornea (HP:0000647) | 1.84077417 |
| 131 | Abnormal lung lobation (HP:0002101) | 1.83249259 |
| 132 | Supernumerary ribs (HP:0005815) | 1.83144944 |
| 133 | Renal duplication (HP:0000075) | 1.82482852 |
| 134 | Increased nuchal translucency (HP:0010880) | 1.82005346 |
| 135 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.80830838 |
| 136 | Pendular nystagmus (HP:0012043) | 1.80698407 |
| 137 | Emotional lability (HP:0000712) | 1.79893692 |
| 138 | Entropion (HP:0000621) | 1.79881214 |
| 139 | Abnormality of the renal collecting system (HP:0004742) | 1.79700301 |
| 140 | Cutaneous melanoma (HP:0012056) | 1.79550012 |
| 141 | Adenoma sebaceum (HP:0009720) | 1.79316201 |
| 142 | Angiofibromas (HP:0010615) | 1.79316201 |
| 143 | Acute lymphatic leukemia (HP:0006721) | 1.78469572 |
| 144 | Leukodystrophy (HP:0002415) | 1.77795624 |
| 145 | Abnormality of cochlea (HP:0000375) | 1.77530548 |
| 146 | Microglossia (HP:0000171) | 1.77197429 |
| 147 | Abnormality of glycolysis (HP:0004366) | 1.76156755 |
| 148 | Overriding aorta (HP:0002623) | 1.75210667 |
| 149 | Achilles tendon contracture (HP:0001771) | 1.75111897 |
| 150 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.74656176 |
| 151 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.74656176 |
| 152 | Abnormal protein glycosylation (HP:0012346) | 1.74656176 |
| 153 | Abnormal glycosylation (HP:0012345) | 1.74656176 |
| 154 | Facial cleft (HP:0002006) | 1.74563075 |
| 155 | Abnormality of alanine metabolism (HP:0010916) | 1.72330097 |
| 156 | Hyperalaninemia (HP:0003348) | 1.72330097 |
| 157 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.72330097 |
| 158 | Poikiloderma (HP:0001029) | 1.71268965 |
| 159 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.70640336 |
| 160 | Fasciculations (HP:0002380) | 1.69582584 |
| 161 | Limb-girdle muscle atrophy (HP:0003797) | 1.68480625 |
| 162 | Cerebellar hypoplasia (HP:0001321) | 1.68084849 |
| 163 | Reduced antithrombin III activity (HP:0001976) | 1.68015461 |
EMC8 
